TY  - JOUR
AU  - Jerotić, Đurđa
AU  - Matić, Marija
AU  - Suvakov, Sonja
AU  - Vučićević, Katarina
AU  - Damnjanović, Tatjana
AU  - Savić-Radojević, Ana
AU  - Plješa-Ercegovac, Marija
AU  - Ćorić, Vesna
AU  - Stefanović, Aleksandra
AU  - Ivanišević, Jasmina
AU  - Jelić-Ivanović, Zorana
AU  - McClements, Lana
AU  - Dimković, Nada
AU  - Simić, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4825
AB  - The oxidative stress response via Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) interlinks inflammation- and metabolism-related pathways in chronic kidney disease. We assessed the association between polymorphisms in Nrf2, superoxide dismutase (SOD2), glutathione peroxidase (GPX1), and the risk of end-stage renal disease (ESRD). The modifying effect of these polymorphisms on both oxidative phenotype and ESRD prognosis, both independently and/or in combination with the glutathione S-transferase M1 (GSTM1) deletion polymorphism, was further analyzed. Polymorphisms in Nrf2 (rs6721961), SOD2 (rs4880), GPX1 (rs1050450), and GSTM1 were determined by PCR in 256 ESRD patients undergoing hemodialysis and 374 controls. Byproducts of oxidative stress were analyzed spectrophotometically or by ELISA. Time-to-event modeling was performed to evaluate overall survival and cardiovascular survival. The SOD2 Val/Val genotype increased ESRD risk (OR = 2.01, p = 0.002), which was even higher in combination with the GPX1 Leu/Leu genotype (OR = 3.27, p = 0.019). Polymorphism in SOD2 also showed an effect on oxidative phenotypes. Overall survival in ESRD patients was dependent on a combination of the Nrf2 (C/C) and GPX1 (Leu/Leu) genotypes in addition to a patients’ age and GSTM1 polymorphism. Similarly, the GPX1 (Leu/Leu) genotype contributed to longer cardiovascular survival. Conclusions: Our results show that SOD2, GPX1, and Nrf2 polymorphisms are associated with ESRD development and can predict survival.
PB  - MDPI
T2  - Toxins
T1  - Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients
VL  - 11
IS  - 7
DO  - 10.3390/toxins11070431
ER  - 

@article{
author = "Jerotić, Đurđa and Matić, Marija and Suvakov, Sonja and Vučićević, Katarina and Damnjanović, Tatjana and Savić-Radojević, Ana and Plješa-Ercegovac, Marija and Ćorić, Vesna and Stefanović, Aleksandra and Ivanišević, Jasmina and Jelić-Ivanović, Zorana and McClements, Lana and Dimković, Nada and Simić, Tatjana",
year = "2019",
abstract = "The oxidative stress response via Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) interlinks inflammation- and metabolism-related pathways in chronic kidney disease. We assessed the association between polymorphisms in Nrf2, superoxide dismutase (SOD2), glutathione peroxidase (GPX1), and the risk of end-stage renal disease (ESRD). The modifying effect of these polymorphisms on both oxidative phenotype and ESRD prognosis, both independently and/or in combination with the glutathione S-transferase M1 (GSTM1) deletion polymorphism, was further analyzed. Polymorphisms in Nrf2 (rs6721961), SOD2 (rs4880), GPX1 (rs1050450), and GSTM1 were determined by PCR in 256 ESRD patients undergoing hemodialysis and 374 controls. Byproducts of oxidative stress were analyzed spectrophotometically or by ELISA. Time-to-event modeling was performed to evaluate overall survival and cardiovascular survival. The SOD2 Val/Val genotype increased ESRD risk (OR = 2.01, p = 0.002), which was even higher in combination with the GPX1 Leu/Leu genotype (OR = 3.27, p = 0.019). Polymorphism in SOD2 also showed an effect on oxidative phenotypes. Overall survival in ESRD patients was dependent on a combination of the Nrf2 (C/C) and GPX1 (Leu/Leu) genotypes in addition to a patients’ age and GSTM1 polymorphism. Similarly, the GPX1 (Leu/Leu) genotype contributed to longer cardiovascular survival. Conclusions: Our results show that SOD2, GPX1, and Nrf2 polymorphisms are associated with ESRD development and can predict survival.",
publisher = "MDPI",
journal = "Toxins",
title = "Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients",
volume = "11",
number = "7",
doi = "10.3390/toxins11070431"
}

Jerotić, Đ., Matić, M., Suvakov, S., Vučićević, K., Damnjanović, T., Savić-Radojević, A., Plješa-Ercegovac, M., Ćorić, V., Stefanović, A., Ivanišević, J., Jelić-Ivanović, Z., McClements, L., Dimković, N.,& Simić, T.. (2019). Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients. in Toxins
MDPI., 11(7).
https://doi.org/10.3390/toxins11070431

Jerotić Đ, Matić M, Suvakov S, Vučićević K, Damnjanović T, Savić-Radojević A, Plješa-Ercegovac M, Ćorić V, Stefanović A, Ivanišević J, Jelić-Ivanović Z, McClements L, Dimković N, Simić T. Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients. in Toxins. 2019;11(7).
doi:10.3390/toxins11070431 .

Jerotić, Đurđa, Matić, Marija, Suvakov, Sonja, Vučićević, Katarina, Damnjanović, Tatjana, Savić-Radojević, Ana, Plješa-Ercegovac, Marija, Ćorić, Vesna, Stefanović, Aleksandra, Ivanišević, Jasmina, Jelić-Ivanović, Zorana, McClements, Lana, Dimković, Nada, Simić, Tatjana, "Association of Nrf2, SOD2 and GPX1 Polymorphisms
with Biomarkers of Oxidative Distress and Survival
in End-Stage Renal Disease Patients" in Toxins, 11, no. 7 (2019),
https://doi.org/10.3390/toxins11070431 . .