TY  - JOUR
AU  - Antunović, Tanja
AU  - Stefanović, Aleksandra
AU  - Gligorović-Barhanović, Najdana
AU  - Miljković, Milica
AU  - Radunović, Danilo
AU  - Ivanišević, Jasmina
AU  - Prelević, Vladimir
AU  - Bulatović, Nebojša
AU  - Ratković, Marina
AU  - Stojanov, Marina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2984
AB  - Oxidative stress and inflammation are highly intertwined pathophysiological processes. We analyzed the markers of these processes and high-sensitive troponin I (hsTnI) for mortality prediction in patients on haemodialysis. This study enrolled a total of 62 patients on regular haemodialysis. The patients were monitored for two years, and the observed outcomes were all-cause and cardiovascular mortality. Blood samples were taken before one dialysis session for analysis of the baseline concentrations of prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), total oxidative status (TOS), hsTnI, hsCRP and resistin. The overall all-cause mortality was 37.1% and CVD mortality 16.1%. By univariate and multivariate logistic regression, our findings suggest that good predictors of all-cause mortality include hsCRP and PAB (p lt .05) and of CVD mortality hsCRP (p lt .05) and hsTnI (p lt .001). To evaluate the relationship between the combined parameter measurements and all-cause/CVD mortality risk, patients were divided into three groups according to their PAB, hsCRP and hsTnI concentrations. The cutoffs for hsCRP and hsTnI and the median for PAB were used. Kaplan-Meier survival curves pointed out that the highest mortality risk of all-cause mortality was in the group with hsCRP levels above the cutoff and PAB levels above the median (p lt .001). The highest risk of CVD mortality was found in the group with hsCRP and hsTnI levels above the cutoff levels (p =.001). Our data suggest that hsCRP and PAB are very good predictors of all-cause mortality. For CVD complications and mortality prediction in HD patients, the most sensitive parameters appear to be hsTnI and hsCRP.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Reproductive Toxicology
T1  - Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up
VL  - 39
IS  - 1
SP  - 491
EP  - 499
DO  - 10.1080/0886022X.2017.1323645
ER  - 

@article{
author = "Antunović, Tanja and Stefanović, Aleksandra and Gligorović-Barhanović, Najdana and Miljković, Milica and Radunović, Danilo and Ivanišević, Jasmina and Prelević, Vladimir and Bulatović, Nebojša and Ratković, Marina and Stojanov, Marina",
year = "2017",
abstract = "Oxidative stress and inflammation are highly intertwined pathophysiological processes. We analyzed the markers of these processes and high-sensitive troponin I (hsTnI) for mortality prediction in patients on haemodialysis. This study enrolled a total of 62 patients on regular haemodialysis. The patients were monitored for two years, and the observed outcomes were all-cause and cardiovascular mortality. Blood samples were taken before one dialysis session for analysis of the baseline concentrations of prooxidant-antioxidant balance (PAB), total antioxidant status (TAS), total oxidative status (TOS), hsTnI, hsCRP and resistin. The overall all-cause mortality was 37.1% and CVD mortality 16.1%. By univariate and multivariate logistic regression, our findings suggest that good predictors of all-cause mortality include hsCRP and PAB (p lt .05) and of CVD mortality hsCRP (p lt .05) and hsTnI (p lt .001). To evaluate the relationship between the combined parameter measurements and all-cause/CVD mortality risk, patients were divided into three groups according to their PAB, hsCRP and hsTnI concentrations. The cutoffs for hsCRP and hsTnI and the median for PAB were used. Kaplan-Meier survival curves pointed out that the highest mortality risk of all-cause mortality was in the group with hsCRP levels above the cutoff and PAB levels above the median (p lt .001). The highest risk of CVD mortality was found in the group with hsCRP and hsTnI levels above the cutoff levels (p =.001). Our data suggest that hsCRP and PAB are very good predictors of all-cause mortality. For CVD complications and mortality prediction in HD patients, the most sensitive parameters appear to be hsTnI and hsCRP.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Reproductive Toxicology",
title = "Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up",
volume = "39",
number = "1",
pages = "491-499",
doi = "10.1080/0886022X.2017.1323645"
}

Antunović, T., Stefanović, A., Gligorović-Barhanović, N., Miljković, M., Radunović, D., Ivanišević, J., Prelević, V., Bulatović, N., Ratković, M.,& Stojanov, M.. (2017). Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up. in Reproductive Toxicology
Taylor & Francis Ltd, Abingdon., 39(1), 491-499.
https://doi.org/10.1080/0886022X.2017.1323645

Antunović T, Stefanović A, Gligorović-Barhanović N, Miljković M, Radunović D, Ivanišević J, Prelević V, Bulatović N, Ratković M, Stojanov M. Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up. in Reproductive Toxicology. 2017;39(1):491-499.
doi:10.1080/0886022X.2017.1323645 .

Antunović, Tanja, Stefanović, Aleksandra, Gligorović-Barhanović, Najdana, Miljković, Milica, Radunović, Danilo, Ivanišević, Jasmina, Prelević, Vladimir, Bulatović, Nebojša, Ratković, Marina, Stojanov, Marina, "Prooxidant-antioxidant balance, hsTnI and hsCRP: mortality prediction in haemodialysis patients, two-year follow-up" in Reproductive Toxicology, 39, no. 1 (2017):491-499,
https://doi.org/10.1080/0886022X.2017.1323645 . .

TY  - JOUR
AU  - Antunović, Tanja
AU  - Stefanović, Aleksandra
AU  - Ratković, Marina
AU  - Gledović, Branka
AU  - Gligorović-Barhanović, Najdana
AU  - Bozović, Dragica
AU  - Ivanišević, Jasmina
AU  - Prostran, Milica
AU  - Stojanov, Marina
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1974
AB  - We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p  lt  0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p  lt  0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p  lt  0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p  lt  0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.
PB  - Springer, Dordrecht
T2  - International Urology and Nephrology
T1  - High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients
VL  - 45
IS  - 4
SP  - 1111
EP  - 1119
DO  - 10.1007/s11255-012-0233-x
ER  - 

@article{
author = "Antunović, Tanja and Stefanović, Aleksandra and Ratković, Marina and Gledović, Branka and Gligorović-Barhanović, Najdana and Bozović, Dragica and Ivanišević, Jasmina and Prostran, Milica and Stojanov, Marina",
year = "2013",
abstract = "We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method. sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p  lt  0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p  lt  0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p  lt  0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p  lt  0.05). Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.",
publisher = "Springer, Dordrecht",
journal = "International Urology and Nephrology",
title = "High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients",
volume = "45",
number = "4",
pages = "1111-1119",
doi = "10.1007/s11255-012-0233-x"
}

Antunović, T., Stefanović, A., Ratković, M., Gledović, B., Gligorović-Barhanović, N., Bozović, D., Ivanišević, J., Prostran, M.,& Stojanov, M.. (2013). High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients. in International Urology and Nephrology
Springer, Dordrecht., 45(4), 1111-1119.
https://doi.org/10.1007/s11255-012-0233-x

Antunović T, Stefanović A, Ratković M, Gledović B, Gligorović-Barhanović N, Bozović D, Ivanišević J, Prostran M, Stojanov M. High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients. in International Urology and Nephrology. 2013;45(4):1111-1119.
doi:10.1007/s11255-012-0233-x .

Antunović, Tanja, Stefanović, Aleksandra, Ratković, Marina, Gledović, Branka, Gligorović-Barhanović, Najdana, Bozović, Dragica, Ivanišević, Jasmina, Prostran, Milica, Stojanov, Marina, "High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients" in International Urology and Nephrology, 45, no. 4 (2013):1111-1119,
https://doi.org/10.1007/s11255-012-0233-x . .