TY  - JOUR
AU  - Franeta, JT
AU  - Agbaba, Danica
AU  - Erić, Slavica
AU  - Pavkov, S
AU  - Aleksić, Mirjana

AU  - Vladimirov, S
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/320
AB  - This paper present a HPLC method for simultaneous determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets, using chromatographic system consisting a Bio Rad 18 01 solvent pump, Rheodine 71 25 injector and Bio Rad 18 01 UV-Vis Detector. Separation was achieved using Bio SiL HL C 18, 5 mum, 250 x 4.6 mm column. Mixture of acetonitrile-water (25:75 v/v) adjusted to pH 2.5 with phosphoric acid was used as a mobile phase at a flow rate of 2.0 ml(-1) min UV detection was at 207 nm range 0.01 AUFS. Under the same conditions it was possible to determine the level of salicylic acid. The chromatographic parameters such as retention times, capacity factor, peak asymmetry, selectivity factor and resolution factor was determined. The validation parameters: linearity (r > 0.998), intra-day precision (RSD: 0.36-1.89%) and inter-day precision (RSD: 0.58-2.18%), sensitivity (LOD: 9 x 10(-5)-1.7 x 10(-4) mg ml(-1) and LOQ: 2.5 x 10(-4)-5.6 x 10(-4) mg ml(-1)), accuracy (recoveries: 98.35-99.14%) and reproducibility (recovery values: 98.74-102.08% for acetylsalicylic acid, 99.93-102.11% for paracetamol, 98.25-102.12% for caffeine and 98.15-102.3% for phenobarbital) (RSD: 1.21-1.85%) were found to be satisfactory. The proposed HPLC method has been applied for the determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in Malophenum tablets. The obtained RSD values were within 0.99-1.21%. The developed method is rapid and sensitive and therefore suitable for routine control of these drugs in dosage form.
PB  - Elsevier Science Sa, Lausanne
T2  - Farmaco
T1  - HPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets
VL  - 57
IS  - 9
SP  - 709
EP  - 713
DO  - 10.1016/S0014-827X(02)01265-X
ER  - 

@article{
author = "Franeta, JT and Agbaba, Danica and Erić, Slavica and Pavkov, S and Aleksić, Mirjana
 and Vladimirov, S",
year = "2002",
abstract = "This paper present a HPLC method for simultaneous determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets, using chromatographic system consisting a Bio Rad 18 01 solvent pump, Rheodine 71 25 injector and Bio Rad 18 01 UV-Vis Detector. Separation was achieved using Bio SiL HL C 18, 5 mum, 250 x 4.6 mm column. Mixture of acetonitrile-water (25:75 v/v) adjusted to pH 2.5 with phosphoric acid was used as a mobile phase at a flow rate of 2.0 ml(-1) min UV detection was at 207 nm range 0.01 AUFS. Under the same conditions it was possible to determine the level of salicylic acid. The chromatographic parameters such as retention times, capacity factor, peak asymmetry, selectivity factor and resolution factor was determined. The validation parameters: linearity (r > 0.998), intra-day precision (RSD: 0.36-1.89%) and inter-day precision (RSD: 0.58-2.18%), sensitivity (LOD: 9 x 10(-5)-1.7 x 10(-4) mg ml(-1) and LOQ: 2.5 x 10(-4)-5.6 x 10(-4) mg ml(-1)), accuracy (recoveries: 98.35-99.14%) and reproducibility (recovery values: 98.74-102.08% for acetylsalicylic acid, 99.93-102.11% for paracetamol, 98.25-102.12% for caffeine and 98.15-102.3% for phenobarbital) (RSD: 1.21-1.85%) were found to be satisfactory. The proposed HPLC method has been applied for the determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in Malophenum tablets. The obtained RSD values were within 0.99-1.21%. The developed method is rapid and sensitive and therefore suitable for routine control of these drugs in dosage form.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Farmaco",
title = "HPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets",
volume = "57",
number = "9",
pages = "709-713",
doi = "10.1016/S0014-827X(02)01265-X"
}

Franeta, J., Agbaba, D., Erić, S., Pavkov, S., Aleksić, M.,& Vladimirov, S.. (2002). HPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets. in Farmaco
Elsevier Science Sa, Lausanne., 57(9), 709-713.
https://doi.org/10.1016/S0014-827X(02)01265-X

Franeta J, Agbaba D, Erić S, Pavkov S, Aleksić M, Vladimirov S. HPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets. in Farmaco. 2002;57(9):709-713.
doi:10.1016/S0014-827X(02)01265-X .

Franeta, JT, Agbaba, Danica, Erić, Slavica, Pavkov, S, Aleksić, Mirjana
, Vladimirov, S, "HPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets" in Farmaco, 57, no. 9 (2002):709-713,
https://doi.org/10.1016/S0014-827X(02)01265-X . .

TY  - JOUR
AU  - Franeta, JT
AU  - Agbaba, Danica
AU  - Erić, Slavica
AU  - Pavkov, SP
AU  - Vladimirov, SD
AU  - Aleksić, Mirjana
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/292
AB  - In the therapy of pain of weaker genesis, frequently used drugs usually represent a mix of analgoantipyretics of different chemical structures, mostly derivatives of salicylic acid, pyrazolone and p-aminophenol as well as derivatives of propionic and acetylsalicylic acid. For the determination of these drugs, different chromatographic methods have been applied, mostly HPLC, due to the the lower polarity (pyrazolones derivatives) and thermolability, as well as nonvolatility of compounds investigated. TLC method, considering advantages which include simplicity, reasonable sensitivity, rapidity, excellent resolving power and low cost has been successfully explored for the determination of analgoantipyretic compounds, The aim of this work was to develop a simple and rapid HPTLC method for the determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbitone in dosage form. The determination of analgoantipyretics were performed on pre-coated HPTLC silica gel plates (10 x 20 cm(2)) by development in the mobile phase dichlormethanethyl acetate-cyclohexane-isopropanol-0.1 M HCL formic acid (9:8:3:1.5:0.2:0.2 v/v/v/v/v/v). Migration distances (68.5 + 0.2 mm, 54.1 + 0.1 mm, 36.4 + 0.14 mtn and 85.9 + 0.11 mm for acetylsalicylic acid, paracetamol. caffeine and phenobarbitone, respectively) with low RSD values (0.13-0.39%) showed a satisfactory reproductivity of the chromatographic system. TLC scanner. was used for direct evaluation of the chromatograms in the reflectance/absorbance mode. Established calibration curves (r > 0.999), precision (0.3-1.02%) and detection limits, as well as recovery values (96.51 98.1%) were validated and found to be satisfactory. The method was found to be reproducible and convenient for the quantitative analysis of compounds investigated in their dosage forms.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Quantitative analysis of analgoantipyretics in dosage form using planar chromatography
VL  - 24
IS  - 5-6
SP  - 1169
EP  - 1173
DO  - 10.1016/S0731-7085(00)00579-3
ER  - 

@article{
author = "Franeta, JT and Agbaba, Danica and Erić, Slavica and Pavkov, SP and Vladimirov, SD and Aleksić, Mirjana",
year = "2001",
abstract = "In the therapy of pain of weaker genesis, frequently used drugs usually represent a mix of analgoantipyretics of different chemical structures, mostly derivatives of salicylic acid, pyrazolone and p-aminophenol as well as derivatives of propionic and acetylsalicylic acid. For the determination of these drugs, different chromatographic methods have been applied, mostly HPLC, due to the the lower polarity (pyrazolones derivatives) and thermolability, as well as nonvolatility of compounds investigated. TLC method, considering advantages which include simplicity, reasonable sensitivity, rapidity, excellent resolving power and low cost has been successfully explored for the determination of analgoantipyretic compounds, The aim of this work was to develop a simple and rapid HPTLC method for the determination of acetylsalicylic acid, paracetamol, caffeine and phenobarbitone in dosage form. The determination of analgoantipyretics were performed on pre-coated HPTLC silica gel plates (10 x 20 cm(2)) by development in the mobile phase dichlormethanethyl acetate-cyclohexane-isopropanol-0.1 M HCL formic acid (9:8:3:1.5:0.2:0.2 v/v/v/v/v/v). Migration distances (68.5 + 0.2 mm, 54.1 + 0.1 mm, 36.4 + 0.14 mtn and 85.9 + 0.11 mm for acetylsalicylic acid, paracetamol. caffeine and phenobarbitone, respectively) with low RSD values (0.13-0.39%) showed a satisfactory reproductivity of the chromatographic system. TLC scanner. was used for direct evaluation of the chromatograms in the reflectance/absorbance mode. Established calibration curves (r > 0.999), precision (0.3-1.02%) and detection limits, as well as recovery values (96.51 98.1%) were validated and found to be satisfactory. The method was found to be reproducible and convenient for the quantitative analysis of compounds investigated in their dosage forms.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Quantitative analysis of analgoantipyretics in dosage form using planar chromatography",
volume = "24",
number = "5-6",
pages = "1169-1173",
doi = "10.1016/S0731-7085(00)00579-3"
}

Franeta, J., Agbaba, D., Erić, S., Pavkov, S., Vladimirov, S.,& Aleksić, M.. (2001). Quantitative analysis of analgoantipyretics in dosage form using planar chromatography. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 24(5-6), 1169-1173.
https://doi.org/10.1016/S0731-7085(00)00579-3

Franeta J, Agbaba D, Erić S, Pavkov S, Vladimirov S, Aleksić M. Quantitative analysis of analgoantipyretics in dosage form using planar chromatography. in Journal of Pharmaceutical and Biomedical Analysis. 2001;24(5-6):1169-1173.
doi:10.1016/S0731-7085(00)00579-3 .

Franeta, JT, Agbaba, Danica, Erić, Slavica, Pavkov, SP, Vladimirov, SD, Aleksić, Mirjana, "Quantitative analysis of analgoantipyretics in dosage form using planar chromatography" in Journal of Pharmaceutical and Biomedical Analysis, 24, no. 5-6 (2001):1169-1173,
https://doi.org/10.1016/S0731-7085(00)00579-3 . .