TY  - JOUR
AU  - Radojević, Branislava
AU  - Dragašević-Mišković, Nataša T.
AU  - Milovanović, Andona
AU  - Svetel, Marina
AU  - Petrović, Igor
AU  - Pešić, Maja
AU  - Tomić, Aleksandra
AU  - Stanisavljević, Dejana
AU  - Savić, Miroslav
AU  - Kostić, Vladimir S.
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4329
AB  - Objectives: Adherence to medication is an important factor that can influence Parkinson's disease (PD) control. We aimed to explore patients' adherence to antiparkinsonian medication and determine factors that might affect adherence to medications among PD patients. Methods: A cross-sectional, exploratory survey of PD patients treated with at least one antiparkinsonian drug and with a total score of MoCA (Montreal Cognitive Assessment) ≥26 was conducted. The final sample included 112 PD patients. A patient's adherence was assessed through ARMS (Adherence to Refills and Medications Scale). ARMS scores higher than 12 were assumed lower adherence. In addition, each patient underwent neurological examination, assessment of depression, anxiety, and evaluation of the presence of PD nonmotor symptoms. Results: The mean ARDS value in our cohort was 14.9 ± 2.5. Most PD patients (74.1%) reported lower adherence to their medication. Participants in the lower adherence group were younger at PD onset, had significantly higher UPDRS (Unified PD Rating Scale) scores, as well as UPDRS III and UPDRS IV subscores, HARS (Hamilton Anxiety Rating Scale), and NMSQuest (Non-Motor Symptoms Questionnaire for PD) scores compared to the fully adherent group (p=0.013, p=0.017, p=0.041, p=0.043, and p=0.023, respectively). Among nonmotor PD symptoms, the presence of cardiovascular, apathy/attention-deficit/memory disorders, hallucinations/delusions, and problems regarding changes in weight, diplopia, or sweating were associated with lower adherence. Multivariate regression analysis revealed depression as the strongest independent predictor of lower adherence. Conclusion: Depressed PD patients compared to PD patients without clinical depression had a three times higher risk for lower adherence to pharmacotherapy. Recognition and adequate treatment of depression might result in improved adherence.
PB  - Hindawi
T2  - International journal of clinical practice
T1  - Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale
VL  - 2022
DO  - 10.1155/2022/6741280
ER  - 

@article{
author = "Radojević, Branislava and Dragašević-Mišković, Nataša T. and Milovanović, Andona and Svetel, Marina and Petrović, Igor and Pešić, Maja and Tomić, Aleksandra and Stanisavljević, Dejana and Savić, Miroslav and Kostić, Vladimir S.",
year = "2022",
abstract = "Objectives: Adherence to medication is an important factor that can influence Parkinson's disease (PD) control. We aimed to explore patients' adherence to antiparkinsonian medication and determine factors that might affect adherence to medications among PD patients. Methods: A cross-sectional, exploratory survey of PD patients treated with at least one antiparkinsonian drug and with a total score of MoCA (Montreal Cognitive Assessment) ≥26 was conducted. The final sample included 112 PD patients. A patient's adherence was assessed through ARMS (Adherence to Refills and Medications Scale). ARMS scores higher than 12 were assumed lower adherence. In addition, each patient underwent neurological examination, assessment of depression, anxiety, and evaluation of the presence of PD nonmotor symptoms. Results: The mean ARDS value in our cohort was 14.9 ± 2.5. Most PD patients (74.1%) reported lower adherence to their medication. Participants in the lower adherence group were younger at PD onset, had significantly higher UPDRS (Unified PD Rating Scale) scores, as well as UPDRS III and UPDRS IV subscores, HARS (Hamilton Anxiety Rating Scale), and NMSQuest (Non-Motor Symptoms Questionnaire for PD) scores compared to the fully adherent group (p=0.013, p=0.017, p=0.041, p=0.043, and p=0.023, respectively). Among nonmotor PD symptoms, the presence of cardiovascular, apathy/attention-deficit/memory disorders, hallucinations/delusions, and problems regarding changes in weight, diplopia, or sweating were associated with lower adherence. Multivariate regression analysis revealed depression as the strongest independent predictor of lower adherence. Conclusion: Depressed PD patients compared to PD patients without clinical depression had a three times higher risk for lower adherence to pharmacotherapy. Recognition and adequate treatment of depression might result in improved adherence.",
publisher = "Hindawi",
journal = "International journal of clinical practice",
title = "Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale",
volume = "2022",
doi = "10.1155/2022/6741280"
}

Radojević, B., Dragašević-Mišković, N. T., Milovanović, A., Svetel, M., Petrović, I., Pešić, M., Tomić, A., Stanisavljević, D., Savić, M.,& Kostić, V. S.. (2022). Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale. in International journal of clinical practice
Hindawi., 2022.
https://doi.org/10.1155/2022/6741280

Radojević B, Dragašević-Mišković NT, Milovanović A, Svetel M, Petrović I, Pešić M, Tomić A, Stanisavljević D, Savić M, Kostić VS. Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale. in International journal of clinical practice. 2022;2022.
doi:10.1155/2022/6741280 .

Radojević, Branislava, Dragašević-Mišković, Nataša T., Milovanović, Andona, Svetel, Marina, Petrović, Igor, Pešić, Maja, Tomić, Aleksandra, Stanisavljević, Dejana, Savić, Miroslav, Kostić, Vladimir S., "Adherence to Medication among Parkinson's Disease Patients Using the Adherence to Refills and Medications Scale" in International journal of clinical practice, 2022 (2022),
https://doi.org/10.1155/2022/6741280 . .