TY  - JOUR
AU  - Kovačević, Ivan
AU  - Miljković, Branislava
AU  - Brzaković, Branka
AU  - Mehmedagić, Aida
AU  - Brujić, Jelena
AU  - Milanović, Marija
AU  - Pokrajac, Milena
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/497
AB  - The aim of this study was to evaluate the influence of smoking on the urine paracetamol elimination. Fourteen healthy female volunteers took part in this controlled study. Seven (23+/-3 years; 50 +/- 2 kg; x+/-SD) were non-smokers and seven (26 +/- 9 years; 58 +/- 8 kg) were smokers (15 cigarettes per day). After administration of 500 mg of paracetamol, urine sampling was performed at specific times (before drug administration and 1, 2, 3, 4, 6, 9, 12, 16 and 24 hours after). The bioanalytical method used for determination of hydrolyzed paracetamol conjugates in urine samples was UV-spectrometry. The obtained pharmacokinetic parameters of paracetamol, first-order elimination rate constant (â) and elimination half-life (t1/2â), were statistically compared between non-smokers and smokers. There were no significant differences in both elimination parameters (â 0.311 1/h; t1/2â 2.23 h non-smokers vs. â 0.346 1/h; t1/2â 2.19 h smokers) between the groups. However, the differences obtained in inter-individual variability in pharmacokinetic parameters (â SD 0.013 , KV 13.4 % ; t1/2â SD 0.227, KV 4.57% nonsmokers vs. â SD 0.108 , KV 90 % ; t1/2â SD 0.684 , KV 14 % smokers) indicate relatively low predictability of paracetamol elimination in smokers. That requires higher attention in dosing this drug in smokers, especially if some other factors also influence.
AB  - U radu je ispitivan uticaj sastojaka duvanskog dima na brzinu eliminacije paracetamola urinom. U kontrolisanom ispitivanju je učestvovalo 14 zdravih dobrovoljaca ženskog pola. Sedam su bili nepušači (23±8 godine; 50±2 kg: X±SD), a sedam (26±9 godina; 58±8 kg; X±SD) pušači (15 cigareta dnevno). Određivan je „ukupan” paracetamol u urinu UV- spektrometrijskom metodom, posle hidrolize konjugata paracetamola i oksidacije dobijenog proizvoda, u prisustvu hipobromita, do obojenog jedinjenja - derivata indofenola. Farmakokinetičkom analizom izmerenih koncentracija u urinu izračunati su farmakokinetički parametri: konstanta brzine eliminacije (â) i poluvreme eliminacije paracetamola (t1/2â). Mada vrednosti ovih parametara kod pušača ukazuju na bržu eliminaciju paracetamola, statističkim poređenjem farmakokinetičkih parametara eliminacije kod pušača (â=0,346 1/h i t1/2â=2,19 h) i nepušača (â=0,311 1/h, t1/2â=2,23 h), nije dobijena značajna razlika ( P lt 0,05). Veće vrednosti SD=0,108 i KV=90 % za â i SD=0,684 i KV= 14, 25 % za t1/2â u grupi pušača, u poređenju sa istim parametrima u grupi nepušača (SD=0,013 i KV=13,4 % za â i SD=0,227 i KV=4,57 % za t1/2â), pokazuju veću inter-individualnu varijabilnost farmakokinetičkih parametara eliminacije paracetamola kod pušača. Posledica je relativno niska predvidivost farmakokinetike paracetamola kod pušača, pa je kod njih potrebna veća pažnja u doziranju leka, naročito ako postoji i uticaj drugih faktora farmakokinetičke varijabilnosti.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - The influence of smoking on the urine paracetamol elimination
T1  - Eliminacija paracetamola urinom kod pušača
VL  - 54
IS  - 5
SP  - 655
EP  - 664
UR  - https://hdl.handle.net/21.15107/rcub_farfar_497
ER  - 

@article{
author = "Kovačević, Ivan and Miljković, Branislava and Brzaković, Branka and Mehmedagić, Aida and Brujić, Jelena and Milanović, Marija and Pokrajac, Milena",
year = "2004",
abstract = "The aim of this study was to evaluate the influence of smoking on the urine paracetamol elimination. Fourteen healthy female volunteers took part in this controlled study. Seven (23+/-3 years; 50 +/- 2 kg; x+/-SD) were non-smokers and seven (26 +/- 9 years; 58 +/- 8 kg) were smokers (15 cigarettes per day). After administration of 500 mg of paracetamol, urine sampling was performed at specific times (before drug administration and 1, 2, 3, 4, 6, 9, 12, 16 and 24 hours after). The bioanalytical method used for determination of hydrolyzed paracetamol conjugates in urine samples was UV-spectrometry. The obtained pharmacokinetic parameters of paracetamol, first-order elimination rate constant (â) and elimination half-life (t1/2â), were statistically compared between non-smokers and smokers. There were no significant differences in both elimination parameters (â 0.311 1/h; t1/2â 2.23 h non-smokers vs. â 0.346 1/h; t1/2â 2.19 h smokers) between the groups. However, the differences obtained in inter-individual variability in pharmacokinetic parameters (â SD 0.013 , KV 13.4 % ; t1/2â SD 0.227, KV 4.57% nonsmokers vs. â SD 0.108 , KV 90 % ; t1/2â SD 0.684 , KV 14 % smokers) indicate relatively low predictability of paracetamol elimination in smokers. That requires higher attention in dosing this drug in smokers, especially if some other factors also influence., U radu je ispitivan uticaj sastojaka duvanskog dima na brzinu eliminacije paracetamola urinom. U kontrolisanom ispitivanju je učestvovalo 14 zdravih dobrovoljaca ženskog pola. Sedam su bili nepušači (23±8 godine; 50±2 kg: X±SD), a sedam (26±9 godina; 58±8 kg; X±SD) pušači (15 cigareta dnevno). Određivan je „ukupan” paracetamol u urinu UV- spektrometrijskom metodom, posle hidrolize konjugata paracetamola i oksidacije dobijenog proizvoda, u prisustvu hipobromita, do obojenog jedinjenja - derivata indofenola. Farmakokinetičkom analizom izmerenih koncentracija u urinu izračunati su farmakokinetički parametri: konstanta brzine eliminacije (â) i poluvreme eliminacije paracetamola (t1/2â). Mada vrednosti ovih parametara kod pušača ukazuju na bržu eliminaciju paracetamola, statističkim poređenjem farmakokinetičkih parametara eliminacije kod pušača (â=0,346 1/h i t1/2â=2,19 h) i nepušača (â=0,311 1/h, t1/2â=2,23 h), nije dobijena značajna razlika ( P lt 0,05). Veće vrednosti SD=0,108 i KV=90 % za â i SD=0,684 i KV= 14, 25 % za t1/2â u grupi pušača, u poređenju sa istim parametrima u grupi nepušača (SD=0,013 i KV=13,4 % za â i SD=0,227 i KV=4,57 % za t1/2â), pokazuju veću inter-individualnu varijabilnost farmakokinetičkih parametara eliminacije paracetamola kod pušača. Posledica je relativno niska predvidivost farmakokinetike paracetamola kod pušača, pa je kod njih potrebna veća pažnja u doziranju leka, naročito ako postoji i uticaj drugih faktora farmakokinetičke varijabilnosti.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The influence of smoking on the urine paracetamol elimination, Eliminacija paracetamola urinom kod pušača",
volume = "54",
number = "5",
pages = "655-664",
url = "https://hdl.handle.net/21.15107/rcub_farfar_497"
}

Kovačević, I., Miljković, B., Brzaković, B., Mehmedagić, A., Brujić, J., Milanović, M.,& Pokrajac, M.. (2004). The influence of smoking on the urine paracetamol elimination. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 54(5), 655-664.
https://hdl.handle.net/21.15107/rcub_farfar_497

Kovačević I, Miljković B, Brzaković B, Mehmedagić A, Brujić J, Milanović M, Pokrajac M. The influence of smoking on the urine paracetamol elimination. in Arhiv za farmaciju. 2004;54(5):655-664.
https://hdl.handle.net/21.15107/rcub_farfar_497 .

Kovačević, Ivan, Miljković, Branislava, Brzaković, Branka, Mehmedagić, Aida, Brujić, Jelena, Milanović, Marija, Pokrajac, Milena, "The influence of smoking on the urine paracetamol elimination" in Arhiv za farmaciju, 54, no. 5 (2004):655-664,
https://hdl.handle.net/21.15107/rcub_farfar_497 .

TY  - CONF
AU  - Kovačević, Ivan
AU  - Miljković, Branislava
AU  - Brzaković, Branka
AU  - Brujić, Jelena
AU  - Milanović, Marija
AU  - Pokrajac, Milena
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/396
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Urine paracetamol elimination in healthy smokers
T1  - Eliminacija paracetamola urinom kod pušača
VL  - 52
IS  - 4
SP  - 670
EP  - 671
UR  - https://hdl.handle.net/21.15107/rcub_farfar_396
ER  - 

@conference{
author = "Kovačević, Ivan and Miljković, Branislava and Brzaković, Branka and Brujić, Jelena and Milanović, Marija and Pokrajac, Milena",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Urine paracetamol elimination in healthy smokers, Eliminacija paracetamola urinom kod pušača",
volume = "52",
number = "4",
pages = "670-671",
url = "https://hdl.handle.net/21.15107/rcub_farfar_396"
}

Kovačević, I., Miljković, B., Brzaković, B., Brujić, J., Milanović, M.,& Pokrajac, M.. (2002). Urine paracetamol elimination in healthy smokers. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 670-671.
https://hdl.handle.net/21.15107/rcub_farfar_396

Kovačević I, Miljković B, Brzaković B, Brujić J, Milanović M, Pokrajac M. Urine paracetamol elimination in healthy smokers. in Arhiv za farmaciju. 2002;52(4):670-671.
https://hdl.handle.net/21.15107/rcub_farfar_396 .

Kovačević, Ivan, Miljković, Branislava, Brzaković, Branka, Brujić, Jelena, Milanović, Marija, Pokrajac, Milena, "Urine paracetamol elimination in healthy smokers" in Arhiv za farmaciju, 52, no. 4 (2002):670-671,
https://hdl.handle.net/21.15107/rcub_farfar_396 .