TY  - JOUR
AU  - Ismaili, L
AU  - Refouvelet, B
AU  - Benchekroun, M
AU  - Brogi, S
AU  - Brindisi, M
AU  - Gemma, S
AU  - Campiani, G
AU  - Filipić, Slavica
AU  - Agbaba, Danica
AU  - Esteban, Gerard
AU  - Unzeta, Mercedes
AU  - Nikolić, Katarina
AU  - Butini, Stefania
AU  - Marco-Contelles, Jose
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2916
AB  - Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation. Based on the involvement of a relevant number of biological systems in Alzheimer's disease progression, multitarget compounds may enable therapeutic efficacy. Accordingly, compounds possessing, besides anticholinergic activity and β-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed. Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as β-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors. The purpose of this review will be to highlight recent reports on the development of multitarget compounds for Alzheimer's disease published within the last years focusing on multifunctional ligands characterized by tacrine-like and donepezil-like structures.
PB  - Elsevier Ltd
T2  - Progress in Neurobiology
T1  - Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
VL  - 151
SP  - 4
EP  - 34
DO  - 10.1016/j.pneurobio.2015.12.003
ER  - 

@article{
author = "Ismaili, L and Refouvelet, B and Benchekroun, M and Brogi, S and Brindisi, M and Gemma, S and Campiani, G and Filipić, Slavica and Agbaba, Danica and Esteban, Gerard and Unzeta, Mercedes and Nikolić, Katarina and Butini, Stefania and Marco-Contelles, Jose",
year = "2017",
abstract = "Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation. Based on the involvement of a relevant number of biological systems in Alzheimer's disease progression, multitarget compounds may enable therapeutic efficacy. Accordingly, compounds possessing, besides anticholinergic activity and β-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed. Other targets relevant to Alzheimer's disease have also been considered in the last years for producing multitarget compounds such as β-secretase, monoamino oxidases, serotonin receptors and sigma 1 receptors. The purpose of this review will be to highlight recent reports on the development of multitarget compounds for Alzheimer's disease published within the last years focusing on multifunctional ligands characterized by tacrine-like and donepezil-like structures.",
publisher = "Elsevier Ltd",
journal = "Progress in Neurobiology",
title = "Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease",
volume = "151",
pages = "4-34",
doi = "10.1016/j.pneurobio.2015.12.003"
}

Ismaili, L., Refouvelet, B., Benchekroun, M., Brogi, S., Brindisi, M., Gemma, S., Campiani, G., Filipić, S., Agbaba, D., Esteban, G., Unzeta, M., Nikolić, K., Butini, S.,& Marco-Contelles, J.. (2017). Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease. in Progress in Neurobiology
Elsevier Ltd., 151, 4-34.
https://doi.org/10.1016/j.pneurobio.2015.12.003

Ismaili L, Refouvelet B, Benchekroun M, Brogi S, Brindisi M, Gemma S, Campiani G, Filipić S, Agbaba D, Esteban G, Unzeta M, Nikolić K, Butini S, Marco-Contelles J. Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease. in Progress in Neurobiology. 2017;151:4-34.
doi:10.1016/j.pneurobio.2015.12.003 .

Ismaili, L, Refouvelet, B, Benchekroun, M, Brogi, S, Brindisi, M, Gemma, S, Campiani, G, Filipić, Slavica, Agbaba, Danica, Esteban, Gerard, Unzeta, Mercedes, Nikolić, Katarina, Butini, Stefania, Marco-Contelles, Jose, "Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease" in Progress in Neurobiology, 151 (2017):4-34,
https://doi.org/10.1016/j.pneurobio.2015.12.003 . .

TY  - JOUR
AU  - Bajić, Vladan
AU  - Potparević, Biljana
AU  - Živković, Lada
AU  - Bonda, David J.
AU  - Siedlak, Sandra L.
AU  - Casadesus, Gemma
AU  - Lee, Hyoung-Gon
AU  - Smith, Mark A.
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1212
AB  - Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region of the X-chromosome in interphase nuclei of lymphocytes from peripheral blood in AD patients, demonstrated premature chromosomal separation before mitotic metaphase directly after completion of DNA replication in G(2) phase of the cell cycle. Furthermore, and perhaps unexpectedly given the presumptive post-mitotic status of terminally differentiated neurons, neurons in AD patients also showed significantly increased levels of PCS of the X-chromosome. Taken together with other phenomena such as cell cycle re-activation and ectopic re-expression of cyclins and cyclin dependent proteins, we propose that AD is an oncogenic phenotype leading to accelarated aging of the affected brain.
PB  - Churchill Livingstone, Edinburgh
T2  - Medical Hypotheses
T1  - The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?
VL  - 73
IS  - 6
SP  - 917
EP  - 920
DO  - 10.1016/j.mehy.2009.06.046
ER  - 

@article{
author = "Bajić, Vladan and Potparević, Biljana and Živković, Lada and Bonda, David J. and Siedlak, Sandra L. and Casadesus, Gemma and Lee, Hyoung-Gon and Smith, Mark A.",
year = "2009",
abstract = "Premature centromere division, or premature centromere separation (PCS), occurs when chromatid separation is dysfunctional, occurring earlier than usual during the interphase stage of mitosis. This phenomenon, seen in Robert's syndrome and various cancers, has also been documented in peripheral as well as neuronal cells of Alzheimer's disease (AD). In the latter instances, fluorescent in situ hybridization (FISH), applied to the centromere region of the X-chromosome in interphase nuclei of lymphocytes from peripheral blood in AD patients, demonstrated premature chromosomal separation before mitotic metaphase directly after completion of DNA replication in G(2) phase of the cell cycle. Furthermore, and perhaps unexpectedly given the presumptive post-mitotic status of terminally differentiated neurons, neurons in AD patients also showed significantly increased levels of PCS of the X-chromosome. Taken together with other phenomena such as cell cycle re-activation and ectopic re-expression of cyclins and cyclin dependent proteins, we propose that AD is an oncogenic phenotype leading to accelarated aging of the affected brain.",
publisher = "Churchill Livingstone, Edinburgh",
journal = "Medical Hypotheses",
title = "The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?",
volume = "73",
number = "6",
pages = "917-920",
doi = "10.1016/j.mehy.2009.06.046"
}

Bajić, V., Potparević, B., Živković, L., Bonda, D. J., Siedlak, S. L., Casadesus, G., Lee, H.,& Smith, M. A.. (2009). The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?. in Medical Hypotheses
Churchill Livingstone, Edinburgh., 73(6), 917-920.
https://doi.org/10.1016/j.mehy.2009.06.046

Bajić V, Potparević B, Živković L, Bonda DJ, Siedlak SL, Casadesus G, Lee H, Smith MA. The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?. in Medical Hypotheses. 2009;73(6):917-920.
doi:10.1016/j.mehy.2009.06.046 .

Bajić, Vladan, Potparević, Biljana, Živković, Lada, Bonda, David J., Siedlak, Sandra L., Casadesus, Gemma, Lee, Hyoung-Gon, Smith, Mark A., "The X-chromosome instability phenotype in Alzheimer's disease: A clinical sign of accelerating aging?" in Medical Hypotheses, 73, no. 6 (2009):917-920,
https://doi.org/10.1016/j.mehy.2009.06.046 . .