TY  - JOUR
AU  - Dangoor, Itzhak
AU  - Stanić, Dušanka
AU  - Reshef, Leah
AU  - Pešić, Vesna
AU  - Gophna, Uri
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3965
AB  - Humans are colonized by bacteria, fungi, archaea, and viruses, which are collectively referred to as the microbiome. Most of the microbiome resides in the gut and may easily be investigated via stool sampling and subsequent metagenomic DNA sequencing. Prolonged exposure to psychiatric pharmacological agents is often associated with marked gastrointestinal phenomena, including changes in food intake, bowel motility, gastric emptying, and transit time [1–3]. Unlike the relatively objective measurement of the microbiota composition, accurate assessment of patients’ therapy adherence and treatment outcomes represent a challenge in psychiatric medical care [4]. This is partly because, for most psychopharmacological agents, compliance and response to treatments are subjectively assessed based on self-reporting and physicians’ evaluations [5,6]. An interesting alternative is having changes in the psychiatric patients’ gut microbiota composition serve as a measurable proxy for monitoring patients’ compliance and the therapeutic effects of some drugs. It is yet unclear how behavioral changes and drug intake affect the microbiota; however, mounting evidence suggests that physical and mental disturbances may lead to changes in gastrointestinal (GI) motility [7,8] in both animals and humans [9–11]. Indeed, in humans, anger, fear, pain, and anxiety, as well as intensive exercise, results in changes in GI activity [8]. In rats, chronic stress results in initial delayed gastric emptying followed by acceleration later on [12]. Medication intake [13,14] and changes in stool consistency, gastric transit, and emptying time [15,16] also have a great impact on microbial composition.
PB  - MDPI
T2  - Microorganisms
T1  - Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes
VL  - 9
IS  - 9
DO  - 10.3390/microorganisms9091938
ER  - 

@article{
author = "Dangoor, Itzhak and Stanić, Dušanka and Reshef, Leah and Pešić, Vesna and Gophna, Uri",
year = "2021",
abstract = "Humans are colonized by bacteria, fungi, archaea, and viruses, which are collectively referred to as the microbiome. Most of the microbiome resides in the gut and may easily be investigated via stool sampling and subsequent metagenomic DNA sequencing. Prolonged exposure to psychiatric pharmacological agents is often associated with marked gastrointestinal phenomena, including changes in food intake, bowel motility, gastric emptying, and transit time [1–3]. Unlike the relatively objective measurement of the microbiota composition, accurate assessment of patients’ therapy adherence and treatment outcomes represent a challenge in psychiatric medical care [4]. This is partly because, for most psychopharmacological agents, compliance and response to treatments are subjectively assessed based on self-reporting and physicians’ evaluations [5,6]. An interesting alternative is having changes in the psychiatric patients’ gut microbiota composition serve as a measurable proxy for monitoring patients’ compliance and the therapeutic effects of some drugs. It is yet unclear how behavioral changes and drug intake affect the microbiota; however, mounting evidence suggests that physical and mental disturbances may lead to changes in gastrointestinal (GI) motility [7,8] in both animals and humans [9–11]. Indeed, in humans, anger, fear, pain, and anxiety, as well as intensive exercise, results in changes in GI activity [8]. In rats, chronic stress results in initial delayed gastric emptying followed by acceleration later on [12]. Medication intake [13,14] and changes in stool consistency, gastric transit, and emptying time [15,16] also have a great impact on microbial composition.",
publisher = "MDPI",
journal = "Microorganisms",
title = "Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes",
volume = "9",
number = "9",
doi = "10.3390/microorganisms9091938"
}

Dangoor, I., Stanić, D., Reshef, L., Pešić, V.,& Gophna, U.. (2021). Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes. in Microorganisms
MDPI., 9(9).
https://doi.org/10.3390/microorganisms9091938

Dangoor I, Stanić D, Reshef L, Pešić V, Gophna U. Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes. in Microorganisms. 2021;9(9).
doi:10.3390/microorganisms9091938 .

Dangoor, Itzhak, Stanić, Dušanka, Reshef, Leah, Pešić, Vesna, Gophna, Uri, "Specific changes in the mammalian gut microbiome as a biomarker for oxytocin-induced behavioral changes" in Microorganisms, 9, no. 9 (2021),
https://doi.org/10.3390/microorganisms9091938 . .

TY  - JOUR
AU  - Stanić, Dušanka
AU  - Oved, Keren
AU  - Israel-Elgali, Ifat
AU  - Jukić, Marin
AU  - Batinić, Bojan
AU  - Puškaš, Nela
AU  - Shomron, Noam
AU  - Gurwitz, David
AU  - Pešić, Vesna
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3883
AB  - Intranasal treatment with oxytocin showed beneficial effects in post-traumatic stress disorder and autism spectrum disorders; however, it was not investigated as much in depression. Keeping in mind the favorable effects of oxytocin on animal models of anxiety and depression, we postulated that synergy between prescribed first choice drugs, selective serotonin reuptake inhibitors (SSRIs) and oxytocin could improve the treatment outcome compared with SSRI monotherapy. Our previous in vitro genome-wide transcriptomic study on human lymphoblastoid cell lines exposed to paroxetine resulted in increase of integrin β3 (ITGB3) gene expression, and further, ITGB3/CHL1 expression ratio was hypothesized to influence the sensitivity to SSRIs. The aim of this report was to explore molecular mechanisms behind the antidepressant-like oxytocin effect, alone and in synergy with citalopram, on behavioral and molecular level in corticosterone treated rats, a paradigm used to model anxiety and depression in animals. Oxytocin treatment (1) ameliorated corticosterone-induced reduction of neurogenesis and number of parvalbumin-positive interneurons in the hippocampal CA1 region, (2) enhanced anxiolytic- and antidepressant-like effects of citalopram in the open field test, and (3) the SSRI/oxytocin synergy persisted in reversing the reduction of the Itgb3 gene expression and increased Itgb3/Chl1 ratio in the prefrontal cortices. These results support the existence of synergy between citalopram and oxytocin in reversing the molecular and behavioral changes induced by corticosterone treatment and point to possible molecular mechanisms behind antidepressant-like effect of oxytocin.
PB  - Elsevier Ltd
T2  - Psychoneuroendocrinology
T1  - Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy
VL  - 129
DO  - 10.1016/j.psyneuen.2021.105234
ER  - 

@article{
author = "Stanić, Dušanka and Oved, Keren and Israel-Elgali, Ifat and Jukić, Marin and Batinić, Bojan and Puškaš, Nela and Shomron, Noam and Gurwitz, David and Pešić, Vesna",
year = "2021",
abstract = "Intranasal treatment with oxytocin showed beneficial effects in post-traumatic stress disorder and autism spectrum disorders; however, it was not investigated as much in depression. Keeping in mind the favorable effects of oxytocin on animal models of anxiety and depression, we postulated that synergy between prescribed first choice drugs, selective serotonin reuptake inhibitors (SSRIs) and oxytocin could improve the treatment outcome compared with SSRI monotherapy. Our previous in vitro genome-wide transcriptomic study on human lymphoblastoid cell lines exposed to paroxetine resulted in increase of integrin β3 (ITGB3) gene expression, and further, ITGB3/CHL1 expression ratio was hypothesized to influence the sensitivity to SSRIs. The aim of this report was to explore molecular mechanisms behind the antidepressant-like oxytocin effect, alone and in synergy with citalopram, on behavioral and molecular level in corticosterone treated rats, a paradigm used to model anxiety and depression in animals. Oxytocin treatment (1) ameliorated corticosterone-induced reduction of neurogenesis and number of parvalbumin-positive interneurons in the hippocampal CA1 region, (2) enhanced anxiolytic- and antidepressant-like effects of citalopram in the open field test, and (3) the SSRI/oxytocin synergy persisted in reversing the reduction of the Itgb3 gene expression and increased Itgb3/Chl1 ratio in the prefrontal cortices. These results support the existence of synergy between citalopram and oxytocin in reversing the molecular and behavioral changes induced by corticosterone treatment and point to possible molecular mechanisms behind antidepressant-like effect of oxytocin.",
publisher = "Elsevier Ltd",
journal = "Psychoneuroendocrinology",
title = "Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy",
volume = "129",
doi = "10.1016/j.psyneuen.2021.105234"
}

Stanić, D., Oved, K., Israel-Elgali, I., Jukić, M., Batinić, B., Puškaš, N., Shomron, N., Gurwitz, D.,& Pešić, V.. (2021). Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy. in Psychoneuroendocrinology
Elsevier Ltd., 129.
https://doi.org/10.1016/j.psyneuen.2021.105234

Stanić D, Oved K, Israel-Elgali I, Jukić M, Batinić B, Puškaš N, Shomron N, Gurwitz D, Pešić V. Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy. in Psychoneuroendocrinology. 2021;129.
doi:10.1016/j.psyneuen.2021.105234 .

Stanić, Dušanka, Oved, Keren, Israel-Elgali, Ifat, Jukić, Marin, Batinić, Bojan, Puškaš, Nela, Shomron, Noam, Gurwitz, David, Pešić, Vesna, "Synergy of oxytocin and citalopram in modulating Itgb3/Chl1 interplay: Relevance to sensitivity to SSRI therapy" in Psychoneuroendocrinology, 129 (2021),
https://doi.org/10.1016/j.psyneuen.2021.105234 . .

TY  - CONF
AU  - Pešić, Vesna
AU  - Dobrosavljević, Ana
AU  - Stanić, Dušanka
AU  - Batinić, Bojan
AU  - Plećaš, Bosiljka
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3299
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Ketamine in a model of depression resistant to tricyclic antidepressants
VL  - 29
IS  - Supplement 1
SP  - S271
EP  - S271
DO  - 10.1016/j.euroneuro.2018.11.430
ER  - 

@conference{
author = "Pešić, Vesna and Dobrosavljević, Ana and Stanić, Dušanka and Batinić, Bojan and Plećaš, Bosiljka",
year = "2019",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Ketamine in a model of depression resistant to tricyclic antidepressants",
volume = "29",
number = "Supplement 1",
pages = "S271-S271",
doi = "10.1016/j.euroneuro.2018.11.430"
}

Pešić, V., Dobrosavljević, A., Stanić, D., Batinić, B.,& Plećaš, B.. (2019). Ketamine in a model of depression resistant to tricyclic antidepressants. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 29(Supplement 1), S271-S271.
https://doi.org/10.1016/j.euroneuro.2018.11.430

Pešić V, Dobrosavljević A, Stanić D, Batinić B, Plećaš B. Ketamine in a model of depression resistant to tricyclic antidepressants. in European Neuropsychopharmacology. 2019;29(Supplement 1):S271-S271.
doi:10.1016/j.euroneuro.2018.11.430 .

Pešić, Vesna, Dobrosavljević, Ana, Stanić, Dušanka, Batinić, Bojan, Plećaš, Bosiljka, "Ketamine in a model of depression resistant to tricyclic antidepressants" in European Neuropsychopharmacology, 29, no. Supplement 1 (2019):S271-S271,
https://doi.org/10.1016/j.euroneuro.2018.11.430 . .

TY  - JOUR
AU  - Durić, Vedrana
AU  - Batinić, Bojan
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Bulat, Zorica
AU  - Pešić, Vesna
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3172
AB  - Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 mu g/animal), mimicking the stress- and depression-like conditions. A single dose of Mg-sulfate enhanced the LTM retrieval in the 24 h inter-trial NORT protocol, in healthy, as well as in rats acutely treated with ACTH. Memory enhancement was also detected after 4-week long Mg-sulfate intake, in both healthy and rats chronically treated with ACTH. While the present findings on procognitive effects of chronic Mg-sulfate treatment corroborate with those from studies on the therapeutic potential of Mg-threonate, the current study is the first to report on memory enhancement induced by a single dose of magnesium.
PB  - John Libbey Eurotext Ltd, Montrouge
T2  - Magnesium Research
T1  - A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats
VL  - 31
IS  - 1
SP  - 24
EP  - 32
DO  - 10.1684/mrh.2018.0435
ER  - 

@article{
author = "Durić, Vedrana and Batinić, Bojan and Petrović, Jelena and Stanić, Dušanka and Bulat, Zorica and Pešić, Vesna",
year = "2018",
abstract = "Although a magnesium-mediated attenuation of memory deficits was reported in animal models of ageing and traumatic brain injury, a possible memory enhancement in healthy subjects has not been investigated yet. We used novel object recognition test (NORT) to examine the effects of acute (30 mg/kg) and chronic (50 mg/kg, 28 days) Mg-sulfate treatment on the long-term memory (LTM) in healthy adult male rats, and to test the sustainability of magnesium effects in the models of acute and chronic (21 days) ACTH administration (10 mu g/animal), mimicking the stress- and depression-like conditions. A single dose of Mg-sulfate enhanced the LTM retrieval in the 24 h inter-trial NORT protocol, in healthy, as well as in rats acutely treated with ACTH. Memory enhancement was also detected after 4-week long Mg-sulfate intake, in both healthy and rats chronically treated with ACTH. While the present findings on procognitive effects of chronic Mg-sulfate treatment corroborate with those from studies on the therapeutic potential of Mg-threonate, the current study is the first to report on memory enhancement induced by a single dose of magnesium.",
publisher = "John Libbey Eurotext Ltd, Montrouge",
journal = "Magnesium Research",
title = "A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats",
volume = "31",
number = "1",
pages = "24-32",
doi = "10.1684/mrh.2018.0435"
}

Durić, V., Batinić, B., Petrović, J., Stanić, D., Bulat, Z.,& Pešić, V.. (2018). A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats. in Magnesium Research
John Libbey Eurotext Ltd, Montrouge., 31(1), 24-32.
https://doi.org/10.1684/mrh.2018.0435

Durić V, Batinić B, Petrović J, Stanić D, Bulat Z, Pešić V. A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats. in Magnesium Research. 2018;31(1):24-32.
doi:10.1684/mrh.2018.0435 .

Durić, Vedrana, Batinić, Bojan, Petrović, Jelena, Stanić, Dušanka, Bulat, Zorica, Pešić, Vesna, "A single dose of magnesium, as well as chronic administration, enhances long-term memory in novel object recognition test, in healthy and ACTH-treated rats" in Magnesium Research, 31, no. 1 (2018):24-32,
https://doi.org/10.1684/mrh.2018.0435 . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Bulat, Zorica
AU  - Puskas, Nela
AU  - Labudović-Borović, Milica
AU  - Batinić, Bojan
AU  - Mirković, Duško
AU  - Ignjatović, Svetlana
AU  - Pešić, Vesna
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3042
AB  - Magnesium (Mg), is not only a modulator of the glutamatergic NMDA receptors' affinity, it also prevents HPA axis hyperactivity, thus possibly being implicated in neurobiological features of mood disorders. Further uncovering of molecular mechanisms underlying magnesium's proposed effects is needed due to the recent shift in research of treatment resistant depression (TRD) towards glutamatergic pathways. Here, we applied Mg via drinking water for 28 days (50 mg/kg/day), in ACTH-treated rats, an established animal model of depression resistant to tricyclic antidepressants. Using this model in male rats we measured (1) changes in hippocampal neurogenesis and behavioral alterations, (2) adrenal hormones response to acute stress challenge and (3) levels of biometals involved in regulation of monoamines turnover in rat prefrontal cortex. Our results support beneficial behavioral impact of Mg in TRD model together with increased hippocampal neurogenesis and BDNF expression. Furthermore, Mg prevented ACTH-induced disruption in HPA axis function, by normalizing the levels of plasma ACTH, corticosterone and interleukin-6, and by increasing the peripheral release of adrenaline, noradrenaline and serotonin after the acute stress challenge. Finally, the influence on copper/zinc ratio suggested probable magnesium's involvement in monoamine turnover in PFC. Our findings provide further insights into the possible pathways implicated in the behavioral modulation effects of Mg, as well as its central and peripheral effects in ACTH-induced TRD model. Thus, further investigation of molecular signaling related to the glutamatergic transmission and role of Mg, could reveal prospects to novel treatment strategies that could be of particular importance for patients suffering from TRD.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Hormones and Behavior
T1  - Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration
VL  - 105
SP  - 1
EP  - 10
DO  - 10.1016/j.yhbeh.2018.07.003
ER  - 

@article{
author = "Petrović, Jelena and Stanić, Dušanka and Bulat, Zorica and Puskas, Nela and Labudović-Borović, Milica and Batinić, Bojan and Mirković, Duško and Ignjatović, Svetlana and Pešić, Vesna",
year = "2018",
abstract = "Magnesium (Mg), is not only a modulator of the glutamatergic NMDA receptors' affinity, it also prevents HPA axis hyperactivity, thus possibly being implicated in neurobiological features of mood disorders. Further uncovering of molecular mechanisms underlying magnesium's proposed effects is needed due to the recent shift in research of treatment resistant depression (TRD) towards glutamatergic pathways. Here, we applied Mg via drinking water for 28 days (50 mg/kg/day), in ACTH-treated rats, an established animal model of depression resistant to tricyclic antidepressants. Using this model in male rats we measured (1) changes in hippocampal neurogenesis and behavioral alterations, (2) adrenal hormones response to acute stress challenge and (3) levels of biometals involved in regulation of monoamines turnover in rat prefrontal cortex. Our results support beneficial behavioral impact of Mg in TRD model together with increased hippocampal neurogenesis and BDNF expression. Furthermore, Mg prevented ACTH-induced disruption in HPA axis function, by normalizing the levels of plasma ACTH, corticosterone and interleukin-6, and by increasing the peripheral release of adrenaline, noradrenaline and serotonin after the acute stress challenge. Finally, the influence on copper/zinc ratio suggested probable magnesium's involvement in monoamine turnover in PFC. Our findings provide further insights into the possible pathways implicated in the behavioral modulation effects of Mg, as well as its central and peripheral effects in ACTH-induced TRD model. Thus, further investigation of molecular signaling related to the glutamatergic transmission and role of Mg, could reveal prospects to novel treatment strategies that could be of particular importance for patients suffering from TRD.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Hormones and Behavior",
title = "Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration",
volume = "105",
pages = "1-10",
doi = "10.1016/j.yhbeh.2018.07.003"
}

Petrović, J., Stanić, D., Bulat, Z., Puskas, N., Labudović-Borović, M., Batinić, B., Mirković, D., Ignjatović, S.,& Pešić, V.. (2018). Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration. in Hormones and Behavior
Academic Press Inc Elsevier Science, San Diego., 105, 1-10.
https://doi.org/10.1016/j.yhbeh.2018.07.003

Petrović J, Stanić D, Bulat Z, Puskas N, Labudović-Borović M, Batinić B, Mirković D, Ignjatović S, Pešić V. Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration. in Hormones and Behavior. 2018;105:1-10.
doi:10.1016/j.yhbeh.2018.07.003 .

Petrović, Jelena, Stanić, Dušanka, Bulat, Zorica, Puskas, Nela, Labudović-Borović, Milica, Batinić, Bojan, Mirković, Duško, Ignjatović, Svetlana, Pešić, Vesna, "Acth-induced model of depression resistant to tricyclic antidepressants: Neuroendocrine and behavioral changes and influence of long-term magnesium administration" in Hormones and Behavior, 105 (2018):1-10,
https://doi.org/10.1016/j.yhbeh.2018.07.003 . .

TY  - CONF
AU  - Petrović, Jelena
AU  - Labudović-Borović, Milica
AU  - Puškaš, Nela
AU  - Stanić, Dušanka
AU  - Batinić, Bojan
AU  - Plećaš-Solarović, Bosiljka
AU  - Pešić, Vesna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2894
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats
VL  - 27
IS  - Supplement 4
SP  - S765
EP  - S766
DO  - 10.1016/S0924-977X(17)31398-6
ER  - 

@conference{
author = "Petrović, Jelena and Labudović-Borović, Milica and Puškaš, Nela and Stanić, Dušanka and Batinić, Bojan and Plećaš-Solarović, Bosiljka and Pešić, Vesna",
year = "2017",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats",
volume = "27",
number = "Supplement 4",
pages = "S765-S766",
doi = "10.1016/S0924-977X(17)31398-6"
}

Petrović, J., Labudović-Borović, M., Puškaš, N., Stanić, D., Batinić, B., Plećaš-Solarović, B.,& Pešić, V.. (2017). Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 27(Supplement 4), S765-S766.
https://doi.org/10.1016/S0924-977X(17)31398-6

Petrović J, Labudović-Borović M, Puškaš N, Stanić D, Batinić B, Plećaš-Solarović B, Pešić V. Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats. in European Neuropsychopharmacology. 2017;27(Supplement 4):S765-S766.
doi:10.1016/S0924-977X(17)31398-6 .

Petrović, Jelena, Labudović-Borović, Milica, Puškaš, Nela, Stanić, Dušanka, Batinić, Bojan, Plećaš-Solarović, Bosiljka, Pešić, Vesna, "Chronic magnesium supplementation increases hippocampal neurogenesis and decreases proliferation in myocardium in ACTH-treated rats" in European Neuropsychopharmacology, 27, no. Supplement 4 (2017):S765-S766,
https://doi.org/10.1016/S0924-977X(17)31398-6 . .

TY  - CONF
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Puškaš, Nela
AU  - Oved, K.
AU  - Gurwitz, D.
AU  - Mirković, Duško
AU  - Plećaš, Bosiljka
AU  - Pešić, Vesna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2870
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats
VL  - 27
IS  - Supplement 1
SP  - S34
EP  - S35
DO  - 10.1016/S0924-977X(17)30104-9
ER  - 

@conference{
author = "Petrović, Jelena and Stanić, Dušanka and Puškaš, Nela and Oved, K. and Gurwitz, D. and Mirković, Duško and Plećaš, Bosiljka and Pešić, Vesna",
year = "2017",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats",
volume = "27",
number = "Supplement 1",
pages = "S34-S35",
doi = "10.1016/S0924-977X(17)30104-9"
}

Petrović, J., Stanić, D., Puškaš, N., Oved, K., Gurwitz, D., Mirković, D., Plećaš, B.,& Pešić, V.. (2017). Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 27(Supplement 1), S34-S35.
https://doi.org/10.1016/S0924-977X(17)30104-9

Petrović J, Stanić D, Puškaš N, Oved K, Gurwitz D, Mirković D, Plećaš B, Pešić V. Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats. in European Neuropsychopharmacology. 2017;27(Supplement 1):S34-S35.
doi:10.1016/S0924-977X(17)30104-9 .

Petrović, Jelena, Stanić, Dušanka, Puškaš, Nela, Oved, K., Gurwitz, D., Mirković, Duško, Plećaš, Bosiljka, Pešić, Vesna, "Oxytocin promotes neurotrophic growth, increases integrin subunit beta 3 (ITGB3) and ameliorates depressive- and anxiety-like behaviour in rats" in European Neuropsychopharmacology, 27, no. Supplement 1 (2017):S34-S35,
https://doi.org/10.1016/S0924-977X(17)30104-9 . .

TY  - THES
AU  - Stanić, Dušanka
PY  - 2017
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=5307
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:16530/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=49497359
UR  - http://nardus.mpn.gov.rs/123456789/8782
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3412
AB  - Poremećaji raspoloženja, uključujući i depresiju, predstavljaju ozbiljne zdravstvene probleme i prema podacima Svetske zdravstvene organizacije do 2020. godine postaće vodeći uzrok radnog onesposobljavanja na globalnom nivou. Poznato je da je hiperaktivnost osovine hipotalamus-hipofiza-nadbubreg (HPA) čest pratilac depresivnih poremećaja, kao i da je hronična izloženost stresu vodeći faktor rizika u razvoju ovih bolesti. Jedan od najvećih problema farmakoterapije depresije predstavlja prilično veliki procenat neadekvatnog odgovora pacijenata na terapiju selektivnim inhibitorima preuzimanja serotonina (SSRI), koji predstavljaju lekove prvog izbora. Stoga, identifikacija biomarkera povoljnog odgovora na terapiju atnidepresivima, kao i pronalaženje eventualnog dodatnog tretmana koji bi povećao verovatnoću dobrog odgovora na terapiju od velikog je kliničkog značaja. Poslednjih godina pokazano je da hormon oksitocin učestvuje u modulaciji ponašanja i raspoloženja kao i da ima ulogu u adaptaciji organizma na hronični stres.Cilj istraživanja obuhvaćenih ovom doktorskom disertacijom bio je da se ispita uticaj oksitocina na ponašanje i parametre aktivnosti HPA osovine u modelu hroničnog stresa/depresije indukovane dugotrajnom primenom kortikosterona kod pacova Wistar soja. Takođe, cilj je bio i da se u navedenom modelu ispita efekat dodatnog tretmana oksitocinom uz antidepresiv citalopram, lek iz grupe SSRI. Da bi se realizovali postavljeni ciljevi, istraživanja su podeljena u tri faze. U prvoj fazi, ispitivan je uticaj različite dužine tretmana kao i različitih doza oksitocina na ponašanje i nivo biogenih amina u plazmi pacova. U drugoj eksperimentalnoj fazi, ispitivan je uticaj tretmana oksitocinom u dozi 10 IU/400 μL, s.c., tokom 14 dana na ponašanje i parametre aktivnosti HPA osovine u modelu hroničnog stresa/depresije izazvane primenom kortikosterona u dozi 100 mg/L, per os, tokom 21. dana...
AB  - Mood disorders, with depression leading the way, are severe health problems and according to the World Health Organization, depression is becoming the leading cause of disability worldwide. It is known that depressive disorders are frequently accompanied with hyperactivity of the Hypothalamic-Pituitary-Adrenal (HPA) axis, as well as that the chronic stress is one of the most important risk-factors for its development. One of the most important problems of depressive disorders pharmacotherapy is that fairly large percentage of patients does not respond adequately to the therapy with selective serotonin reuptake inhibitors (SSRI), which are the first-line treatment drugs. Therefore, the identification of biomarkers of favorable response to antidepressant therapy, as well as discoveries of potential additional treatments, which would increase the probability of favorable response to the primary therapy is of the major clinical importance. In recent years, it has been shown that the hormone oxytocin modulates mood and behavior, and mediates adaptation feedback-response against chronic stress.The aim of the doctoral dissertation research was to evaluate the influence of oxytocin on the behavior and parameters of HPA axis activity, in the model of the long-term corticosterone administration-induced depression-like symptoms in adult male Wistar rats. Furthermore, the aim was to examine the potential beneficial effect of administering oxytocin alongside citalopram, an antidepressant from SSRI group, in this animal model. In order to fulfil these aims, the experimental work has been conducted in three phases. In the first phase, the effects of different treatment durations and dosages of oxytocin on behavior and plasma levels of biogenic amines were evaluated. In the second experimental phase, the effects of 14-day long oxytocin treatment (10 IU/400 μL, s.c.) on behavior and HPA axis activity in the model of chronic stress/depression induced by 21-day long corticosterone administration (100 mg/L, per os) were investigated...
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Uticaj oksitocina na aktivnost osovine hipotalamus-hipofiza-nadbubreg i ponašanje pacova
UR  - https://hdl.handle.net/21.15107/rcub_nardus_8782
ER  - 

@phdthesis{
author = "Stanić, Dušanka",
year = "2017",
abstract = "Poremećaji raspoloženja, uključujući i depresiju, predstavljaju ozbiljne zdravstvene probleme i prema podacima Svetske zdravstvene organizacije do 2020. godine postaće vodeći uzrok radnog onesposobljavanja na globalnom nivou. Poznato je da je hiperaktivnost osovine hipotalamus-hipofiza-nadbubreg (HPA) čest pratilac depresivnih poremećaja, kao i da je hronična izloženost stresu vodeći faktor rizika u razvoju ovih bolesti. Jedan od najvećih problema farmakoterapije depresije predstavlja prilično veliki procenat neadekvatnog odgovora pacijenata na terapiju selektivnim inhibitorima preuzimanja serotonina (SSRI), koji predstavljaju lekove prvog izbora. Stoga, identifikacija biomarkera povoljnog odgovora na terapiju atnidepresivima, kao i pronalaženje eventualnog dodatnog tretmana koji bi povećao verovatnoću dobrog odgovora na terapiju od velikog je kliničkog značaja. Poslednjih godina pokazano je da hormon oksitocin učestvuje u modulaciji ponašanja i raspoloženja kao i da ima ulogu u adaptaciji organizma na hronični stres.Cilj istraživanja obuhvaćenih ovom doktorskom disertacijom bio je da se ispita uticaj oksitocina na ponašanje i parametre aktivnosti HPA osovine u modelu hroničnog stresa/depresije indukovane dugotrajnom primenom kortikosterona kod pacova Wistar soja. Takođe, cilj je bio i da se u navedenom modelu ispita efekat dodatnog tretmana oksitocinom uz antidepresiv citalopram, lek iz grupe SSRI. Da bi se realizovali postavljeni ciljevi, istraživanja su podeljena u tri faze. U prvoj fazi, ispitivan je uticaj različite dužine tretmana kao i različitih doza oksitocina na ponašanje i nivo biogenih amina u plazmi pacova. U drugoj eksperimentalnoj fazi, ispitivan je uticaj tretmana oksitocinom u dozi 10 IU/400 μL, s.c., tokom 14 dana na ponašanje i parametre aktivnosti HPA osovine u modelu hroničnog stresa/depresije izazvane primenom kortikosterona u dozi 100 mg/L, per os, tokom 21. dana..., Mood disorders, with depression leading the way, are severe health problems and according to the World Health Organization, depression is becoming the leading cause of disability worldwide. It is known that depressive disorders are frequently accompanied with hyperactivity of the Hypothalamic-Pituitary-Adrenal (HPA) axis, as well as that the chronic stress is one of the most important risk-factors for its development. One of the most important problems of depressive disorders pharmacotherapy is that fairly large percentage of patients does not respond adequately to the therapy with selective serotonin reuptake inhibitors (SSRI), which are the first-line treatment drugs. Therefore, the identification of biomarkers of favorable response to antidepressant therapy, as well as discoveries of potential additional treatments, which would increase the probability of favorable response to the primary therapy is of the major clinical importance. In recent years, it has been shown that the hormone oxytocin modulates mood and behavior, and mediates adaptation feedback-response against chronic stress.The aim of the doctoral dissertation research was to evaluate the influence of oxytocin on the behavior and parameters of HPA axis activity, in the model of the long-term corticosterone administration-induced depression-like symptoms in adult male Wistar rats. Furthermore, the aim was to examine the potential beneficial effect of administering oxytocin alongside citalopram, an antidepressant from SSRI group, in this animal model. In order to fulfil these aims, the experimental work has been conducted in three phases. In the first phase, the effects of different treatment durations and dosages of oxytocin on behavior and plasma levels of biogenic amines were evaluated. In the second experimental phase, the effects of 14-day long oxytocin treatment (10 IU/400 μL, s.c.) on behavior and HPA axis activity in the model of chronic stress/depression induced by 21-day long corticosterone administration (100 mg/L, per os) were investigated...",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Uticaj oksitocina na aktivnost osovine hipotalamus-hipofiza-nadbubreg i ponašanje pacova",
url = "https://hdl.handle.net/21.15107/rcub_nardus_8782"
}

Stanić, D.. (2017). Uticaj oksitocina na aktivnost osovine hipotalamus-hipofiza-nadbubreg i ponašanje pacova. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_8782

Stanić D. Uticaj oksitocina na aktivnost osovine hipotalamus-hipofiza-nadbubreg i ponašanje pacova. in Универзитет у Београду. 2017;.
https://hdl.handle.net/21.15107/rcub_nardus_8782 .

Stanić, Dušanka, "Uticaj oksitocina na aktivnost osovine hipotalamus-hipofiza-nadbubreg i ponašanje pacova" in Универзитет у Београду (2017),
https://hdl.handle.net/21.15107/rcub_nardus_8782 .

TY  - JOUR
AU  - Stanić, Dušanka
AU  - Plećaš-Solarović, Bosiljka
AU  - Mirković, Duško
AU  - Jovanović, Predrag
AU  - Dronjak, Slađana
AU  - Marković, Bojan
AU  - Dondević, Tea
AU  - Ignjatović, Svetlana
AU  - Pešić, Vesna
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3012
AB  - Chronic stress conditions can lead to considerable and extensible changes in physiological and psychological performances, and in emergence of risk for various somatic diseases. On the other hand, the neuropeptide oxytocin is reported to increase the resistance of the organism to stress and modulate activity of autonomic nervous system. Chronic corticosterone administration is used as a rat model for a state observed in terms of chronic stress exposure, when negative feedback mechanism of hypothalamus-pituitary-adrenal axis activity is disrupted. In our study, we aimed to investigate whether chronic administration of oxytocin (10114400 pI/day for 14 days, s.c.) influenced adrenal gland morphology and activity in adult male Wistar rats during long-term corticosterone administration via drinking water (100 mg/L for 21 days). We examined the influence of treatments on the levels of adrenal gland hormones, corticosterone, adrenaline and noradrenaline, as well as their response to an acute stress challenge evoked by 15-min forced swimming. In addition, the expression of two main monoamine transporters, the noradrenaline transporter (NAT) and vesicular monoamine transporter 2 (VMAT2) in adrenal medulla was measured in the rats exposed to acute stress. Our results showed that oxytocin treatment prevented corticosterone-induced decrease in body weight gain, attenuated adrenal gland atrophy by increasing glandular weight, and the area of the zona fasciculate and reticularis. Chronic corticosterone intake blunted the response of all measured hormones to acute stress, whereas concomitant oxytocin treatment reversed adrenaline and noradrenaline response to acute stress. Furthermore, in adrenal medulla, oxytocin produced significant vasodilatation and stimulated expression of both catecholamine transporters detected both on mRNA and protein level. Our data suggest that oxytocin, by reducing atrophy of adrenal gland, and by increasing catecholamine storage capacity, may be beneficial in conditions accompanied with high glucocorticoid levels, such as chronic stress exposure.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Psychopharmacology
T1  - Oxytocin in corticosterone-induced chronic stress model: Focus on adrenal gland function
VL  - 80
SP  - 137
EP  - 146
DO  - 10.1016/j.psyneuen.2017.03.011
ER  - 

@article{
author = "Stanić, Dušanka and Plećaš-Solarović, Bosiljka and Mirković, Duško and Jovanović, Predrag and Dronjak, Slađana and Marković, Bojan and Dondević, Tea and Ignjatović, Svetlana and Pešić, Vesna",
year = "2017",
abstract = "Chronic stress conditions can lead to considerable and extensible changes in physiological and psychological performances, and in emergence of risk for various somatic diseases. On the other hand, the neuropeptide oxytocin is reported to increase the resistance of the organism to stress and modulate activity of autonomic nervous system. Chronic corticosterone administration is used as a rat model for a state observed in terms of chronic stress exposure, when negative feedback mechanism of hypothalamus-pituitary-adrenal axis activity is disrupted. In our study, we aimed to investigate whether chronic administration of oxytocin (10114400 pI/day for 14 days, s.c.) influenced adrenal gland morphology and activity in adult male Wistar rats during long-term corticosterone administration via drinking water (100 mg/L for 21 days). We examined the influence of treatments on the levels of adrenal gland hormones, corticosterone, adrenaline and noradrenaline, as well as their response to an acute stress challenge evoked by 15-min forced swimming. In addition, the expression of two main monoamine transporters, the noradrenaline transporter (NAT) and vesicular monoamine transporter 2 (VMAT2) in adrenal medulla was measured in the rats exposed to acute stress. Our results showed that oxytocin treatment prevented corticosterone-induced decrease in body weight gain, attenuated adrenal gland atrophy by increasing glandular weight, and the area of the zona fasciculate and reticularis. Chronic corticosterone intake blunted the response of all measured hormones to acute stress, whereas concomitant oxytocin treatment reversed adrenaline and noradrenaline response to acute stress. Furthermore, in adrenal medulla, oxytocin produced significant vasodilatation and stimulated expression of both catecholamine transporters detected both on mRNA and protein level. Our data suggest that oxytocin, by reducing atrophy of adrenal gland, and by increasing catecholamine storage capacity, may be beneficial in conditions accompanied with high glucocorticoid levels, such as chronic stress exposure.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Psychopharmacology",
title = "Oxytocin in corticosterone-induced chronic stress model: Focus on adrenal gland function",
volume = "80",
pages = "137-146",
doi = "10.1016/j.psyneuen.2017.03.011"
}

Stanić, D., Plećaš-Solarović, B., Mirković, D., Jovanović, P., Dronjak, S., Marković, B., Dondević, T., Ignjatović, S.,& Pešić, V.. (2017). Oxytocin in corticosterone-induced chronic stress model: Focus on adrenal gland function. in Psychopharmacology
Pergamon-Elsevier Science Ltd, Oxford., 80, 137-146.
https://doi.org/10.1016/j.psyneuen.2017.03.011

Stanić D, Plećaš-Solarović B, Mirković D, Jovanović P, Dronjak S, Marković B, Dondević T, Ignjatović S, Pešić V. Oxytocin in corticosterone-induced chronic stress model: Focus on adrenal gland function. in Psychopharmacology. 2017;80:137-146.
doi:10.1016/j.psyneuen.2017.03.011 .

Stanić, Dušanka, Plećaš-Solarović, Bosiljka, Mirković, Duško, Jovanović, Predrag, Dronjak, Slađana, Marković, Bojan, Dondević, Tea, Ignjatović, Svetlana, Pešić, Vesna, "Oxytocin in corticosterone-induced chronic stress model: Focus on adrenal gland function" in Psychopharmacology, 80 (2017):137-146,
https://doi.org/10.1016/j.psyneuen.2017.03.011 . .

TY  - JOUR
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Dmitrašinović, Gordana
AU  - Plećaš-Solarović, Bosiljka
AU  - Ignjatović, Svetlana
AU  - Batinić, Bojan
AU  - Popović, Dejana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2557
AB  - Sedentary lifestyle is highly associated with increased risk of cardiovascular disease, obesity, and type 2 diabetes. It is known that regular physical activity has positive effects on health; however several studies have shown that acute and strenuous exercise can induce oxidative stress and lead to DNA damage. As magnesium is essential in maintaining DNA integrity, the aim of this study was to determine whether four-week-long magnesium supplementation in students with sedentary lifestyle and rugby players could prevent or diminish impairment of DNA. By using the comet assay, our study demonstrated that the number of peripheral blood lymphocytes (PBL) with basal endogenous DNA damage is significantly higher in rugby players compared to students with sedentary lifestyle. On the other hand, magnesium supplementation significantly decreased the number of cells with high DNA damage, in the presence of exogenous H2O2, in PBL from both students and rugby players, and markedly reduced the number of cells with medium DNA damage in rugby players compared to corresponding control nonsupplemented group. Accordingly, the results of our study suggest that four-week-long magnesium supplementation has marked effects in protecting the DNA from oxidative damage in both rugby players and in young men with sedentary lifestyle.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine and Cellular Longevity
T1  - Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man
DO  - 10.1155/2016/2019643
ER  - 

@article{
author = "Petrović, Jelena and Stanić, Dušanka and Dmitrašinović, Gordana and Plećaš-Solarović, Bosiljka and Ignjatović, Svetlana and Batinić, Bojan and Popović, Dejana and Pešić, Vesna",
year = "2016",
abstract = "Sedentary lifestyle is highly associated with increased risk of cardiovascular disease, obesity, and type 2 diabetes. It is known that regular physical activity has positive effects on health; however several studies have shown that acute and strenuous exercise can induce oxidative stress and lead to DNA damage. As magnesium is essential in maintaining DNA integrity, the aim of this study was to determine whether four-week-long magnesium supplementation in students with sedentary lifestyle and rugby players could prevent or diminish impairment of DNA. By using the comet assay, our study demonstrated that the number of peripheral blood lymphocytes (PBL) with basal endogenous DNA damage is significantly higher in rugby players compared to students with sedentary lifestyle. On the other hand, magnesium supplementation significantly decreased the number of cells with high DNA damage, in the presence of exogenous H2O2, in PBL from both students and rugby players, and markedly reduced the number of cells with medium DNA damage in rugby players compared to corresponding control nonsupplemented group. Accordingly, the results of our study suggest that four-week-long magnesium supplementation has marked effects in protecting the DNA from oxidative damage in both rugby players and in young men with sedentary lifestyle.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man",
doi = "10.1155/2016/2019643"
}

Petrović, J., Stanić, D., Dmitrašinović, G., Plećaš-Solarović, B., Ignjatović, S., Batinić, B., Popović, D.,& Pešić, V.. (2016). Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man. in Oxidative Medicine and Cellular Longevity
Hindawi Ltd, London..
https://doi.org/10.1155/2016/2019643

Petrović J, Stanić D, Dmitrašinović G, Plećaš-Solarović B, Ignjatović S, Batinić B, Popović D, Pešić V. Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man. in Oxidative Medicine and Cellular Longevity. 2016;.
doi:10.1155/2016/2019643 .

Petrović, Jelena, Stanić, Dušanka, Dmitrašinović, Gordana, Plećaš-Solarović, Bosiljka, Ignjatović, Svetlana, Batinić, Bojan, Popović, Dejana, Pešić, Vesna, "Magnesium Supplementation Diminishes Peripheral Blood Lymphocyte DNA Oxidative Damage in Athletes and Sedentary Young Man" in Oxidative Medicine and Cellular Longevity (2016),
https://doi.org/10.1155/2016/2019643 . .

TY  - JOUR
AU  - Stanić, Dušanka
AU  - Plećaš-Solarović, Bosiljka
AU  - Petrović, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Sopić, Miron
AU  - Kotur-Stevuljević, Jelena
AU  - Ignjatović, Svetlana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2704
AB  - Contemporary lifestyle is commonly associated with chronic stress, an environmental factor contributing to development of various psychological and somatic disorders. Increased levels of glucocorticoids, observed in the chronic stress, induce the production of reactive oxygen species leading to genotoxicity. The aim of this study was to investigate whether chronic administration of oxytocin (OXY) 10 IU/400 mu L/day, s.c., for 14 days, a hormone presumed to exert antioxidant effect, may prevent DNA damage in the comet assay of peripheral blood lymphocytes of Wistar rats treated chronically with corticosterone (CORT) 100 mg/L ad libitum, per os, for 21 days, as well as, to influence some plasma oxidative stress parameters, i.e. levels of total lipid hydroperoxide (LOOH), and malondialdehyde (MDA), and the activity of antioxidative enzyme superoxide dismutase (SOD). Even though there was no reduction in overall number of damaged cells after oxytocin treatment only, the marked increase in total comet score (TCS) after incubation with H2O2 in CORT group compared to controls, was absent in the CORT + OXY experimental group. Furthermore, significant decrease of highly damaged cells compared to corticosterone group was noted. Chronic oxytocin administration thus protected lymphocytes from high intensity damage that leads to cellular death. In addition, treatment with OXY along with CORT, significantly decreased concentration of LOOH in plasma, and increased SOD compared to CORT treatment only. This finding corresponds well with current reports on beneficial effects of OXY in conditions of HPA axis hyperactivity, and supports the hypothesis of OXY-mediated antioxidant action.
PB  - Elsevier Ireland Ltd, Clare
T2  - Chemico-Biological Interactions
T1  - Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment
VL  - 256
SP  - 134
EP  - 141
DO  - 10.1016/j.cbi.2016.07.006
ER  - 

@article{
author = "Stanić, Dušanka and Plećaš-Solarović, Bosiljka and Petrović, Jelena and Bogavac-Stanojević, Nataša and Sopić, Miron and Kotur-Stevuljević, Jelena and Ignjatović, Svetlana and Pešić, Vesna",
year = "2016",
abstract = "Contemporary lifestyle is commonly associated with chronic stress, an environmental factor contributing to development of various psychological and somatic disorders. Increased levels of glucocorticoids, observed in the chronic stress, induce the production of reactive oxygen species leading to genotoxicity. The aim of this study was to investigate whether chronic administration of oxytocin (OXY) 10 IU/400 mu L/day, s.c., for 14 days, a hormone presumed to exert antioxidant effect, may prevent DNA damage in the comet assay of peripheral blood lymphocytes of Wistar rats treated chronically with corticosterone (CORT) 100 mg/L ad libitum, per os, for 21 days, as well as, to influence some plasma oxidative stress parameters, i.e. levels of total lipid hydroperoxide (LOOH), and malondialdehyde (MDA), and the activity of antioxidative enzyme superoxide dismutase (SOD). Even though there was no reduction in overall number of damaged cells after oxytocin treatment only, the marked increase in total comet score (TCS) after incubation with H2O2 in CORT group compared to controls, was absent in the CORT + OXY experimental group. Furthermore, significant decrease of highly damaged cells compared to corticosterone group was noted. Chronic oxytocin administration thus protected lymphocytes from high intensity damage that leads to cellular death. In addition, treatment with OXY along with CORT, significantly decreased concentration of LOOH in plasma, and increased SOD compared to CORT treatment only. This finding corresponds well with current reports on beneficial effects of OXY in conditions of HPA axis hyperactivity, and supports the hypothesis of OXY-mediated antioxidant action.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Chemico-Biological Interactions",
title = "Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment",
volume = "256",
pages = "134-141",
doi = "10.1016/j.cbi.2016.07.006"
}

Stanić, D., Plećaš-Solarović, B., Petrović, J., Bogavac-Stanojević, N., Sopić, M., Kotur-Stevuljević, J., Ignjatović, S.,& Pešić, V.. (2016). Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment. in Chemico-Biological Interactions
Elsevier Ireland Ltd, Clare., 256, 134-141.
https://doi.org/10.1016/j.cbi.2016.07.006

Stanić D, Plećaš-Solarović B, Petrović J, Bogavac-Stanojević N, Sopić M, Kotur-Stevuljević J, Ignjatović S, Pešić V. Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment. in Chemico-Biological Interactions. 2016;256:134-141.
doi:10.1016/j.cbi.2016.07.006 .

Stanić, Dušanka, Plećaš-Solarović, Bosiljka, Petrović, Jelena, Bogavac-Stanojević, Nataša, Sopić, Miron, Kotur-Stevuljević, Jelena, Ignjatović, Svetlana, Pešić, Vesna, "Hydrogen peroxide-induced oxidative damage in peripheral blood lymphocytes from rats chronically treated with corticosterone: The protective effect of oxytocin treatment" in Chemico-Biological Interactions, 256 (2016):134-141,
https://doi.org/10.1016/j.cbi.2016.07.006 . .

TY  - CONF
AU  - Petrović, Jelena
AU  - Stanić, Dušanka
AU  - Mirković, Duško
AU  - Batinić, Bojan
AU  - Plećaš, Bosiljka
AU  - Ignjatović, Svetlana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2687
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone
VL  - 26
IS  - Supplement 2
SP  - S207
EP  - S207
DO  - 10.1016/S0924-977X(16)31053-7
ER  - 

@conference{
author = "Petrović, Jelena and Stanić, Dušanka and Mirković, Duško and Batinić, Bojan and Plećaš, Bosiljka and Ignjatović, Svetlana and Pešić, Vesna",
year = "2016",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone",
volume = "26",
number = "Supplement 2",
pages = "S207-S207",
doi = "10.1016/S0924-977X(16)31053-7"
}

Petrović, J., Stanić, D., Mirković, D., Batinić, B., Plećaš, B., Ignjatović, S.,& Pešić, V.. (2016). Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 26(Supplement 2), S207-S207.
https://doi.org/10.1016/S0924-977X(16)31053-7

Petrović J, Stanić D, Mirković D, Batinić B, Plećaš B, Ignjatović S, Pešić V. Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone. in European Neuropsychopharmacology. 2016;26(Supplement 2):S207-S207.
doi:10.1016/S0924-977X(16)31053-7 .

Petrović, Jelena, Stanić, Dušanka, Mirković, Duško, Batinić, Bojan, Plećaš, Bosiljka, Ignjatović, Svetlana, Pešić, Vesna, "Effects of long-term magnesium administration on levels of stress hormones and interleukin-6 after acute stress in rats chronically treated with adrenocorticotropic hormone" in European Neuropsychopharmacology, 26, no. Supplement 2 (2016):S207-S207,
https://doi.org/10.1016/S0924-977X(16)31053-7 . .

TY  - CONF
AU  - Stanić, Dušanka
AU  - Petrović, Jelena
AU  - Mirković, Duško
AU  - Đorđević, Tea
AU  - Durić, V.
AU  - Jovanović, P.
AU  - Dronjak, Slađana
AU  - Pešić, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2686
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone
VL  - 26
IS  - Supplement 2
SP  - S204
EP  - S204
DO  - 10.1016/S0924-977X(16)31048-3
ER  - 

@conference{
author = "Stanić, Dušanka and Petrović, Jelena and Mirković, Duško and Đorđević, Tea and Durić, V. and Jovanović, P. and Dronjak, Slađana and Pešić, Vesna",
year = "2016",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone",
volume = "26",
number = "Supplement 2",
pages = "S204-S204",
doi = "10.1016/S0924-977X(16)31048-3"
}

Stanić, D., Petrović, J., Mirković, D., Đorđević, T., Durić, V., Jovanović, P., Dronjak, S.,& Pešić, V.. (2016). Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 26(Supplement 2), S204-S204.
https://doi.org/10.1016/S0924-977X(16)31048-3

Stanić D, Petrović J, Mirković D, Đorđević T, Durić V, Jovanović P, Dronjak S, Pešić V. Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone. in European Neuropsychopharmacology. 2016;26(Supplement 2):S204-S204.
doi:10.1016/S0924-977X(16)31048-3 .

Stanić, Dušanka, Petrović, Jelena, Mirković, Duško, Đorđević, Tea, Durić, V., Jovanović, P., Dronjak, Slađana, Pešić, Vesna, "Oxytocin modulates HPA axis activity and hormone response to stress in rats chronically treated with corticosterone" in European Neuropsychopharmacology, 26, no. Supplement 2 (2016):S204-S204,
https://doi.org/10.1016/S0924-977X(16)31048-3 . .

TY  - CONF
AU  - Pešić, Vesna
AU  - Stanić, Dušanka
AU  - Petrović, Jelena
AU  - Puskas, Nela
AU  - Plećaš, Bosiljka
AU  - Ignjatović, Svetlana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2656
PB  - Elsevier Science BV, Amsterdam
C3  - European Neuropsychopharmacology
T1  - Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment
VL  - 26
IS  - Supplement 2
SP  - S289
EP  - S289
DO  - 10.1016/S0924-977X(16)31184-1
ER  - 

@conference{
author = "Pešić, Vesna and Stanić, Dušanka and Petrović, Jelena and Puskas, Nela and Plećaš, Bosiljka and Ignjatović, Svetlana",
year = "2016",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Neuropsychopharmacology",
title = "Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment",
volume = "26",
number = "Supplement 2",
pages = "S289-S289",
doi = "10.1016/S0924-977X(16)31184-1"
}

Pešić, V., Stanić, D., Petrović, J., Puskas, N., Plećaš, B.,& Ignjatović, S.. (2016). Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment. in European Neuropsychopharmacology
Elsevier Science BV, Amsterdam., 26(Supplement 2), S289-S289.
https://doi.org/10.1016/S0924-977X(16)31184-1

Pešić V, Stanić D, Petrović J, Puskas N, Plećaš B, Ignjatović S. Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment. in European Neuropsychopharmacology. 2016;26(Supplement 2):S289-S289.
doi:10.1016/S0924-977X(16)31184-1 .

Pešić, Vesna, Stanić, Dušanka, Petrović, Jelena, Puskas, Nela, Plećaš, Bosiljka, Ignjatović, Svetlana, "Oxytocin affects changes in behaviour, BDNF and Ki-67 expression in hippocampus, caused by chronic corticosterone treatment" in European Neuropsychopharmacology, 26, no. Supplement 2 (2016):S289-S289,
https://doi.org/10.1016/S0924-977X(16)31184-1 . .

TY  - JOUR
AU  - Dmitrasinović, Gordana
AU  - Pešić, Vesna
AU  - Stanić, Dušanka
AU  - Plećaš-Solarović, Bosiljka
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2748
AB  - Background: Physical exercise activates the hypothalamopituitary-adrenal (HPA) axis and induces the body's inflammatory response. Due to contemporary dietary habits and increased energy expenditure, athletes are susceptible to depletion of magnesium ions. The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce damaging stress effects in amateur rugby players. Methods: Rugby players (N=23) were randomly assigned to intervention and control group. Basal samples were collected before intervention group started a 4-week-long supplementation with magnesium (500 mg Mg/d). Blood and saliva sampling were done a day before the match (Day-1), on the morning of competition (Game), and during a six-day-long recovery period (Day1, Day3 and Day6). ACTH, serum/salivary cortisol, IL-6 and total/differential leukocytes counts were determined at each time point. Results: There was a statistically significant increase in ACTH concentration in intervention group compared to control group, while reductions in cortisol concentrations between the two groups were the greatest at Day-1 (p lt 0.01) and at the day of competition (Game) (p lt 0.01). Our results revealed that magnesium completely abolished the increase in IL-6 level noted in control group on Day1 and Day3 vs. Day-1 (p lt 0.01) and also diminished the rise in neutrophil/lymphocyte ratio in intervention group vs. control group (p lt 0.01). Conclusions: These results suggest the possibly important influence magnesium supplementation might have on the change of parameters of HPA axis activity and reduction of immune response activation following strenuous physical exercise such as a rugby game.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation
VL  - 35
IS  - 4
SP  - 375
EP  - 384
DO  - 10.1515/jomb-2016-0021
ER  - 

@article{
author = "Dmitrasinović, Gordana and Pešić, Vesna and Stanić, Dušanka and Plećaš-Solarović, Bosiljka and Dajak, Marijana and Ignjatović, Svetlana",
year = "2016",
abstract = "Background: Physical exercise activates the hypothalamopituitary-adrenal (HPA) axis and induces the body's inflammatory response. Due to contemporary dietary habits and increased energy expenditure, athletes are susceptible to depletion of magnesium ions. The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce damaging stress effects in amateur rugby players. Methods: Rugby players (N=23) were randomly assigned to intervention and control group. Basal samples were collected before intervention group started a 4-week-long supplementation with magnesium (500 mg Mg/d). Blood and saliva sampling were done a day before the match (Day-1), on the morning of competition (Game), and during a six-day-long recovery period (Day1, Day3 and Day6). ACTH, serum/salivary cortisol, IL-6 and total/differential leukocytes counts were determined at each time point. Results: There was a statistically significant increase in ACTH concentration in intervention group compared to control group, while reductions in cortisol concentrations between the two groups were the greatest at Day-1 (p lt 0.01) and at the day of competition (Game) (p lt 0.01). Our results revealed that magnesium completely abolished the increase in IL-6 level noted in control group on Day1 and Day3 vs. Day-1 (p lt 0.01) and also diminished the rise in neutrophil/lymphocyte ratio in intervention group vs. control group (p lt 0.01). Conclusions: These results suggest the possibly important influence magnesium supplementation might have on the change of parameters of HPA axis activity and reduction of immune response activation following strenuous physical exercise such as a rugby game.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation",
volume = "35",
number = "4",
pages = "375-384",
doi = "10.1515/jomb-2016-0021"
}

Dmitrasinović, G., Pešić, V., Stanić, D., Plećaš-Solarović, B., Dajak, M.,& Ignjatović, S.. (2016). ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(4), 375-384.
https://doi.org/10.1515/jomb-2016-0021

Dmitrasinović G, Pešić V, Stanić D, Plećaš-Solarović B, Dajak M, Ignjatović S. ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation. in Journal of Medical Biochemistry. 2016;35(4):375-384.
doi:10.1515/jomb-2016-0021 .

Dmitrasinović, Gordana, Pešić, Vesna, Stanić, Dušanka, Plećaš-Solarović, Bosiljka, Dajak, Marijana, Ignjatović, Svetlana, "ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation" in Journal of Medical Biochemistry, 35, no. 4 (2016):375-384,
https://doi.org/10.1515/jomb-2016-0021 . .