TY  - JOUR
AU  - Medenica, Mirjana
AU  - Ivanović, D.
AU  - Magković, M.
AU  - Jančić, Biljana
AU  - Malenović, Anđelija
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/968
AB  - Perindopril tert-butylamine is a new member of angiotensin-converting enzyme inhibitors group used in the treatment of hypertension and heart failure. In this paper, the evaluation of reversed-phase high-performance liquid chromatographic method (RP-HPLC) for the determination of impurities level of perindopril tert-butylamine in tablets was done. The chromatograms were recorded using a Hewlett Packard 1100 chromatographic system with DAD detector. Separations were performed on a YMC-Pack C8 column (250 mm x 4.6 mm; 5 mu m particle size) at 50 degrees C column temperature. Mobile phase was a mixture of acetonitrile-potassium phosphate buffer (0.05 M) (37:63, v/v) (pH 2.5). pH of the mobile phase was adjusted with ortophosphoric acid. Mixture of acetonitrile-water (40:60, v/v) was used as a solvent. Injection volume was 50 mu l, flow rate 1.7 ml min(-1) and UV-detection was performed at 215 nm. The developed method subjected to method validation and parameters in terms of selectivity, linearity, precision, accuracy, limit of detection, limit of quantitation and robustness were defined. The validated method is suitable for the simultaneous determination of perindopril tert-butylamine as well as its impurities in pharmaceuticals.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Evaluation of impurities level of perindopril tert-butylamine in tablets
VL  - 44
IS  - 5
SP  - 1087
EP  - 1094
DO  - 10.1016/j.jpba.2007.05.008
ER  - 

@article{
author = "Medenica, Mirjana and Ivanović, D. and Magković, M. and Jančić, Biljana and Malenović, Anđelija",
year = "2007",
abstract = "Perindopril tert-butylamine is a new member of angiotensin-converting enzyme inhibitors group used in the treatment of hypertension and heart failure. In this paper, the evaluation of reversed-phase high-performance liquid chromatographic method (RP-HPLC) for the determination of impurities level of perindopril tert-butylamine in tablets was done. The chromatograms were recorded using a Hewlett Packard 1100 chromatographic system with DAD detector. Separations were performed on a YMC-Pack C8 column (250 mm x 4.6 mm; 5 mu m particle size) at 50 degrees C column temperature. Mobile phase was a mixture of acetonitrile-potassium phosphate buffer (0.05 M) (37:63, v/v) (pH 2.5). pH of the mobile phase was adjusted with ortophosphoric acid. Mixture of acetonitrile-water (40:60, v/v) was used as a solvent. Injection volume was 50 mu l, flow rate 1.7 ml min(-1) and UV-detection was performed at 215 nm. The developed method subjected to method validation and parameters in terms of selectivity, linearity, precision, accuracy, limit of detection, limit of quantitation and robustness were defined. The validated method is suitable for the simultaneous determination of perindopril tert-butylamine as well as its impurities in pharmaceuticals.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Evaluation of impurities level of perindopril tert-butylamine in tablets",
volume = "44",
number = "5",
pages = "1087-1094",
doi = "10.1016/j.jpba.2007.05.008"
}

Medenica, M., Ivanović, D., Magković, M., Jančić, B.,& Malenović, A.. (2007). Evaluation of impurities level of perindopril tert-butylamine in tablets. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 44(5), 1087-1094.
https://doi.org/10.1016/j.jpba.2007.05.008

Medenica M, Ivanović D, Magković M, Jančić B, Malenović A. Evaluation of impurities level of perindopril tert-butylamine in tablets. in Journal of Pharmaceutical and Biomedical Analysis. 2007;44(5):1087-1094.
doi:10.1016/j.jpba.2007.05.008 .

Medenica, Mirjana, Ivanović, D., Magković, M., Jančić, Biljana, Malenović, Anđelija, "Evaluation of impurities level of perindopril tert-butylamine in tablets" in Journal of Pharmaceutical and Biomedical Analysis, 44, no. 5 (2007):1087-1094,
https://doi.org/10.1016/j.jpba.2007.05.008 . .