TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Krajišnik, Danina
AU  - Micić, Zorica
AU  - Čalija, Bojan
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2762
AB  - Carbomer based hydrogels with 1% of 18 beta-glycyrrhetinic acid complex in the form of phytosomes (18 beta-GAP) were formulated by using Carbopol (R) 980 and Carbopol (R) Ultrez 10 as gelling agents (1%), sodium hydroxide (neutralizing agent) (0.4%), glycerol (humectant) (10%), Sepicide (R) HB (preservative) (1%), and water (up to 100%). In order to prepare the hydrogels, 18 beta-GAP was dispersed into the water phase prior the carbomer neutralization or the 18 beta-GAP aqueous dispersion was added into the previously neutralized carbomer dispersion. The pH values (6.71 +/- 0.16-7.09 +/- 0.06), soft semisolid consistency and spreadability (25.7 +/- 1.5 mm-33.7 +/- 0.6 mm) of the hydrogels were acceptable for application on the skin. The influence of the preparation procedure, the carbomer type, and addition of a humectant (glycerol 10%) on physicochemical properties was evaluated using light microscopy, DSC analysis and rheological behavior characterization. The preparation procedure, the carbomer type, and the addition of the humectant did not affect significantly organoleptic and morphological characteristics and spread-ability of the hydrogels. The Carbopol (R) 980 based hydrogels were more sensitive than hydrogels based on Carbopol (R) Ultrez 10 upon thermal variations regarding the water evaporation loss. Physical stability of the investigated hydrogels was satisfactory for minimum 30 days of storage at a temperature range from +4 degrees C up to +40 degrees C.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Drug Delivery Science and Technology
T1  - Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes
VL  - 35
SP  - 81
EP  - 90
DO  - 10.1016/j.jddst.2016.06.008
ER  - 

@article{
author = "Đekić, Ljiljana and Krajišnik, Danina and Micić, Zorica and Čalija, Bojan",
year = "2016",
abstract = "Carbomer based hydrogels with 1% of 18 beta-glycyrrhetinic acid complex in the form of phytosomes (18 beta-GAP) were formulated by using Carbopol (R) 980 and Carbopol (R) Ultrez 10 as gelling agents (1%), sodium hydroxide (neutralizing agent) (0.4%), glycerol (humectant) (10%), Sepicide (R) HB (preservative) (1%), and water (up to 100%). In order to prepare the hydrogels, 18 beta-GAP was dispersed into the water phase prior the carbomer neutralization or the 18 beta-GAP aqueous dispersion was added into the previously neutralized carbomer dispersion. The pH values (6.71 +/- 0.16-7.09 +/- 0.06), soft semisolid consistency and spreadability (25.7 +/- 1.5 mm-33.7 +/- 0.6 mm) of the hydrogels were acceptable for application on the skin. The influence of the preparation procedure, the carbomer type, and addition of a humectant (glycerol 10%) on physicochemical properties was evaluated using light microscopy, DSC analysis and rheological behavior characterization. The preparation procedure, the carbomer type, and the addition of the humectant did not affect significantly organoleptic and morphological characteristics and spread-ability of the hydrogels. The Carbopol (R) 980 based hydrogels were more sensitive than hydrogels based on Carbopol (R) Ultrez 10 upon thermal variations regarding the water evaporation loss. Physical stability of the investigated hydrogels was satisfactory for minimum 30 days of storage at a temperature range from +4 degrees C up to +40 degrees C.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Drug Delivery Science and Technology",
title = "Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes",
volume = "35",
pages = "81-90",
doi = "10.1016/j.jddst.2016.06.008"
}

Đekić, L., Krajišnik, D., Micić, Z.,& Čalija, B.. (2016). Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes. in Journal of Drug Delivery Science and Technology
Elsevier Science BV, Amsterdam., 35, 81-90.
https://doi.org/10.1016/j.jddst.2016.06.008

Đekić L, Krajišnik D, Micić Z, Čalija B. Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes. in Journal of Drug Delivery Science and Technology. 2016;35:81-90.
doi:10.1016/j.jddst.2016.06.008 .

Đekić, Ljiljana, Krajišnik, Danina, Micić, Zorica, Čalija, Bojan, "Formulation and physicochemical characterization of hydrogels with 18 beta-glycyrrhetinic acid/phospholipid complex phytosomes" in Journal of Drug Delivery Science and Technology, 35 (2016):81-90,
https://doi.org/10.1016/j.jddst.2016.06.008 . .

TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Krajišnik, Danina
AU  - Micić, Zorica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2425
AB  - Phospholipids and polyphenolic phytoconstituents may form specific molecular complexes (polyphenolics-phospholipid complexes, phyto-phospholipid complexes) with definite chemical structure, solubility, thermal and spectroscopic characteristics. Furthermore, such specific molecular entities may self-associate into spherical unilamellar vesicles (phyto-vesicles, herbosomes) with size at nano-or microscale. Phyto-phospholipid complexation was recognised as a promising strategy to improve formulation performances and enhance efficiency of herbal polyphenolics with cosmetic relevance in comparison with pure phytoconstituents. This concise review summarizes the current knowledge on preparation methods, physico-chemical properties and aspects of application of the selected phyto-complexes as cosmetic active ingredients.
PB  - Carl Hanser Verlag, Munich
T2  - Tenside Surfactants Detergents
T1  - Polyphenolics-Phospholipid Complexes as Natural Cosmetic Ingredients: Properties and Application
VL  - 52
IS  - 3
SP  - 186
EP  - 192
DO  - 10.3139/113.110364
ER  - 

@article{
author = "Đekić, Ljiljana and Krajišnik, Danina and Micić, Zorica",
year = "2015",
abstract = "Phospholipids and polyphenolic phytoconstituents may form specific molecular complexes (polyphenolics-phospholipid complexes, phyto-phospholipid complexes) with definite chemical structure, solubility, thermal and spectroscopic characteristics. Furthermore, such specific molecular entities may self-associate into spherical unilamellar vesicles (phyto-vesicles, herbosomes) with size at nano-or microscale. Phyto-phospholipid complexation was recognised as a promising strategy to improve formulation performances and enhance efficiency of herbal polyphenolics with cosmetic relevance in comparison with pure phytoconstituents. This concise review summarizes the current knowledge on preparation methods, physico-chemical properties and aspects of application of the selected phyto-complexes as cosmetic active ingredients.",
publisher = "Carl Hanser Verlag, Munich",
journal = "Tenside Surfactants Detergents",
title = "Polyphenolics-Phospholipid Complexes as Natural Cosmetic Ingredients: Properties and Application",
volume = "52",
number = "3",
pages = "186-192",
doi = "10.3139/113.110364"
}

Đekić, L., Krajišnik, D.,& Micić, Z.. (2015). Polyphenolics-Phospholipid Complexes as Natural Cosmetic Ingredients: Properties and Application. in Tenside Surfactants Detergents
Carl Hanser Verlag, Munich., 52(3), 186-192.
https://doi.org/10.3139/113.110364

Đekić L, Krajišnik D, Micić Z. Polyphenolics-Phospholipid Complexes as Natural Cosmetic Ingredients: Properties and Application. in Tenside Surfactants Detergents. 2015;52(3):186-192.
doi:10.3139/113.110364 .

Đekić, Ljiljana, Krajišnik, Danina, Micić, Zorica, "Polyphenolics-Phospholipid Complexes as Natural Cosmetic Ingredients: Properties and Application" in Tenside Surfactants Detergents, 52, no. 3 (2015):186-192,
https://doi.org/10.3139/113.110364 . .