TY  - JOUR
AU  - Jaćević, Vesna
AU  - Grujić-Milanović, Jelica
AU  - Milovanović, Zoran
AU  - Nežić, Lana
AU  - Amidžić, Ljiljana
AU  - Vojinović, Nataša
AU  - Marković, Bojan
AU  - Dobričić, Vladimir
AU  - Milosavljević, Petar
AU  - Nepovimova, Eugenie
AU  - Kuča, Kamil
PY  - 2024
PY  - Elsevier Ireland Ltd
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5702
AB  - Oxidative stress status, as a disruption of redox homeostasis, in the blood sera of Wistar rats caused by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated. Throughout this study, each oxime in a dose of 0.1 of LD50/kg im was given 2x/week for 4 weeks. Then, seven days after the last oximes' application, markers of lipid peroxidation (malondialdehyde, MDA), and protein oxidation (advanced oxidation protein products, AOPP), as well as the activity of antioxidant enzymes (catalase, CAT, superoxide dismutase, SOD, reduced glutathione, GSH, and oxidized glutathione, GSSG), were determined. Oxidative stress parameters, MDA and AOPP were significantly highest in the K048-, K074- and K075-treated groups (p < 0.001). The activity of CAT was significantly elevated in the obidoxime-treated group (p < 0.05), while treatment with K027, K048, and K074 induced high elevation in SOD levels (p < 0.01, p < 0.001). Interestingly, the activity of GSH in each oxime-treated group was significantly elevated. Unlike, treatment with obidoxime caused elevation in GSSG levels (p < 0.01). As a continuation of our previously published data, these results assure that applied oximes following subacute treatment ameliorated the oxidative status and further adverse systemic toxic effects in rats.
PB  - Elsevier Ireland Ltd
T2  - Chemico-Biological Interactions
T1  - Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats
VL  - 399
DO  - 10.1016/j.cbi.2024.111138
ER  - 

@article{
author = "Jaćević, Vesna and Grujić-Milanović, Jelica and Milovanović, Zoran and Nežić, Lana and Amidžić, Ljiljana and Vojinović, Nataša and Marković, Bojan and Dobričić, Vladimir and Milosavljević, Petar and Nepovimova, Eugenie and Kuča, Kamil",
year = "2024, Elsevier Ireland Ltd",
abstract = "Oxidative stress status, as a disruption of redox homeostasis, in the blood sera of Wistar rats caused by repeated application of selected acetylcholinesterase reactivators - asoxime, obidoxime, K027, K048, K074, and K075 were evaluated. Throughout this study, each oxime in a dose of 0.1 of LD50/kg im was given 2x/week for 4 weeks. Then, seven days after the last oximes' application, markers of lipid peroxidation (malondialdehyde, MDA), and protein oxidation (advanced oxidation protein products, AOPP), as well as the activity of antioxidant enzymes (catalase, CAT, superoxide dismutase, SOD, reduced glutathione, GSH, and oxidized glutathione, GSSG), were determined. Oxidative stress parameters, MDA and AOPP were significantly highest in the K048-, K074- and K075-treated groups (p < 0.001). The activity of CAT was significantly elevated in the obidoxime-treated group (p < 0.05), while treatment with K027, K048, and K074 induced high elevation in SOD levels (p < 0.01, p < 0.001). Interestingly, the activity of GSH in each oxime-treated group was significantly elevated. Unlike, treatment with obidoxime caused elevation in GSSG levels (p < 0.01). As a continuation of our previously published data, these results assure that applied oximes following subacute treatment ameliorated the oxidative status and further adverse systemic toxic effects in rats.",
publisher = "Elsevier Ireland Ltd",
journal = "Chemico-Biological Interactions",
title = "Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats",
volume = "399",
doi = "10.1016/j.cbi.2024.111138"
}

Jaćević, V., Grujić-Milanović, J., Milovanović, Z., Nežić, L., Amidžić, L., Vojinović, N., Marković, B., Dobričić, V., Milosavljević, P., Nepovimova, E.,& Kuča, K.. (2024). Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats. in Chemico-Biological Interactions
Elsevier Ireland Ltd., 399.
https://doi.org/10.1016/j.cbi.2024.111138

Jaćević V, Grujić-Milanović J, Milovanović Z, Nežić L, Amidžić L, Vojinović N, Marković B, Dobričić V, Milosavljević P, Nepovimova E, Kuča K. Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats. in Chemico-Biological Interactions. 2024;399.
doi:10.1016/j.cbi.2024.111138 .

Jaćević, Vesna, Grujić-Milanović, Jelica, Milovanović, Zoran, Nežić, Lana, Amidžić, Ljiljana, Vojinović, Nataša, Marković, Bojan, Dobričić, Vladimir, Milosavljević, Petar, Nepovimova, Eugenie, Kuča, Kamil, "Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats" in Chemico-Biological Interactions, 399 (2024),
https://doi.org/10.1016/j.cbi.2024.111138 . .

Jaćević, V., Dumanović, J., Grujić-Milanović, J., Milovanović, Z., Amidžić, L., Vojinović, N., Nežić, L., Marković, B., Dobričić, V., Milosavljević, P., Nepovimova, E.,& Kuča, K.. (2023). Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes. in Chemico-biological interactions
Elsevier B.V.., 383, 110658.
https://doi.org/10.1016/j.cbi.2023.110658

Jaćević V, Dumanović J, Grujić-Milanović J, Milovanović Z, Amidžić L, Vojinović N, Nežić L, Marković B, Dobričić V, Milosavljević P, Nepovimova E, Kuča K. Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes. in Chemico-biological interactions. 2023;383:110658.
doi:10.1016/j.cbi.2023.110658 .

Jaćević, Vesna, Dumanović, Jelena, Grujić-Milanović, Jelica, Milovanović, Zoran, Amidžić, Ljiljana, Vojinović, Nataša, Nežić, Lana, Marković, Bojan, Dobričić, Vladimir, Milosavljević, Petar, Nepovimova, Eugenie, Kuča, Kamil, "Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes" in Chemico-biological interactions, 383 (2023):110658,
https://doi.org/10.1016/j.cbi.2023.110658 . .