TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Pavlović, Željko
AU  - Primorac, Marija
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2810
AB  - Liquid spray preparations for cutaneous administration are solutions, suspensions or emulsions that use compressed or converted gas to a liquid state, to disperse the active substance in the form of aerosols or they are propellant-free (not pressurized) pumps and can also disperse the active substance in the form of aerosols. The paper presents data from professional regulations and relevant literature related to dosage forms, characteristics and composition of cutaneous sprays, and on inner packaging (containers and pump/valve systems and sprays), which is their main specificity. They are most commonly formulated as cutaneous spray, solution, for local administration of antimicrobials, or for regional delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) and transdermal delivery of hormones. In the development of transdermal sprays, great attention is paid to strategies for improving the drug delivery and therapeutic efficacy (e.g., by using permeation enhancers, colloidal carriers). Equally important is design of inner packaging that should ensure preservation of drug quality, but also precise and reproductive dosing according to the individual therapeutic needs of patients, which, with simple application, good tolerance and satisfactory aesthetic properties, is a significant advantage of cutaneous sprays compared to other liquid and semisolid preparations for cutaneous administration as well as transdermal patches.
AB  - Tečni sprej preparati (sprejevi) za kožu su rastvori, suspenzije ili emulzije koji koriste snagu komprimovanog ili gasa prevedenog u tečno stanje, za raspršivanje aktivne supstance u vidu aerosola ili su to preparati sa pumpom koji ne sadrže propelent (nisu pod pritiskom) i takođe mogu raspršiti aktivnu supstancu u obliku aerosola. U radu su navedeni podaci iz stručnih propisa i relevantne stručne literature koji se odnose na farmaceutske oblike, karakteristike i sastav sprejeva za kožu, i na unutrašnje pakovanje (kontejneri i sistemi pumpi/ventila i raspršivača), koje predstavlja glavnu specifičnost ovih preparata. Najčešće se formulišu u obliku sprejeva za kožu, rastvora, za lokalnu primenu atimikrobnih supstanci ili za regionalnu isporuku nesteroidnih antiiflamatornih lekova (NSAIL) i transdermalnu isporuku hormona. U razvoju transdermalnih sprejeva za kožu velika pažnja se pridaje strategijama za unapređenje isporuke lekovitih supstanci i njihove terapijske efikasnosti (npr. korišćenjem permeacionih inhensera, koloidnih nosača). Podjednako značajan je i dizajn unutrašnjeg pakovanja koje treba da obezbedi očuvanje kvaliteta leka, ali i precizno i reproduktivno doziranje u skladu sa individualnim terapijskim potrebama pacijenata, što je uz jednostavnu primenu, dobru podnošljivost i zadovoljavajuća estetska svojstva, značajna prednost sprejeva za kožu u poređenju sa ostalim tečnim i polučvrstim preparatima za primenu na koži i transdermalnim flasterima.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Characteristics and application of cutaneous spray preparations in dermal and transdermal drug delivery
T1  - Karakteristike i mogućnosti primene sprejeva za kožu u dermalnoj i transdermalnoj isporuci lekova
VL  - 67
IS  - 6
SP  - 345
EP  - 359
DO  - 10.5937/arhfarm1706345D
ER  - 

@article{
author = "Đekić, Ljiljana and Pavlović, Željko and Primorac, Marija",
year = "2017",
abstract = "Liquid spray preparations for cutaneous administration are solutions, suspensions or emulsions that use compressed or converted gas to a liquid state, to disperse the active substance in the form of aerosols or they are propellant-free (not pressurized) pumps and can also disperse the active substance in the form of aerosols. The paper presents data from professional regulations and relevant literature related to dosage forms, characteristics and composition of cutaneous sprays, and on inner packaging (containers and pump/valve systems and sprays), which is their main specificity. They are most commonly formulated as cutaneous spray, solution, for local administration of antimicrobials, or for regional delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) and transdermal delivery of hormones. In the development of transdermal sprays, great attention is paid to strategies for improving the drug delivery and therapeutic efficacy (e.g., by using permeation enhancers, colloidal carriers). Equally important is design of inner packaging that should ensure preservation of drug quality, but also precise and reproductive dosing according to the individual therapeutic needs of patients, which, with simple application, good tolerance and satisfactory aesthetic properties, is a significant advantage of cutaneous sprays compared to other liquid and semisolid preparations for cutaneous administration as well as transdermal patches., Tečni sprej preparati (sprejevi) za kožu su rastvori, suspenzije ili emulzije koji koriste snagu komprimovanog ili gasa prevedenog u tečno stanje, za raspršivanje aktivne supstance u vidu aerosola ili su to preparati sa pumpom koji ne sadrže propelent (nisu pod pritiskom) i takođe mogu raspršiti aktivnu supstancu u obliku aerosola. U radu su navedeni podaci iz stručnih propisa i relevantne stručne literature koji se odnose na farmaceutske oblike, karakteristike i sastav sprejeva za kožu, i na unutrašnje pakovanje (kontejneri i sistemi pumpi/ventila i raspršivača), koje predstavlja glavnu specifičnost ovih preparata. Najčešće se formulišu u obliku sprejeva za kožu, rastvora, za lokalnu primenu atimikrobnih supstanci ili za regionalnu isporuku nesteroidnih antiiflamatornih lekova (NSAIL) i transdermalnu isporuku hormona. U razvoju transdermalnih sprejeva za kožu velika pažnja se pridaje strategijama za unapređenje isporuke lekovitih supstanci i njihove terapijske efikasnosti (npr. korišćenjem permeacionih inhensera, koloidnih nosača). Podjednako značajan je i dizajn unutrašnjeg pakovanja koje treba da obezbedi očuvanje kvaliteta leka, ali i precizno i reproduktivno doziranje u skladu sa individualnim terapijskim potrebama pacijenata, što je uz jednostavnu primenu, dobru podnošljivost i zadovoljavajuća estetska svojstva, značajna prednost sprejeva za kožu u poređenju sa ostalim tečnim i polučvrstim preparatima za primenu na koži i transdermalnim flasterima.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Characteristics and application of cutaneous spray preparations in dermal and transdermal drug delivery, Karakteristike i mogućnosti primene sprejeva za kožu u dermalnoj i transdermalnoj isporuci lekova",
volume = "67",
number = "6",
pages = "345-359",
doi = "10.5937/arhfarm1706345D"
}

Đekić, L., Pavlović, Ž.,& Primorac, M.. (2017). Characteristics and application of cutaneous spray preparations in dermal and transdermal drug delivery. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 67(6), 345-359.
https://doi.org/10.5937/arhfarm1706345D

Đekić L, Pavlović Ž, Primorac M. Characteristics and application of cutaneous spray preparations in dermal and transdermal drug delivery. in Arhiv za farmaciju. 2017;67(6):345-359.
doi:10.5937/arhfarm1706345D .

Đekić, Ljiljana, Pavlović, Željko, Primorac, Marija, "Characteristics and application of cutaneous spray preparations in dermal and transdermal drug delivery" in Arhiv za farmaciju, 67, no. 6 (2017):345-359,
https://doi.org/10.5937/arhfarm1706345D . .