TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Vasović, Novak
AU  - Černe, Darko
AU  - Kos, Janko
AU  - Bogavac-Stanojević, Nataša
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3448
AB  - Cathepsin S (CTSS) is a cysteine protease involved in atherogenesis. We compared the plasma CTSS as well as other biomarkers of atherosclerosis in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD), aiming to identify the underlying pathogenic mechanisms of the disease development. Also, we hypothesised that the level of plasma CTSS simultaneously increases with a decrease of plasma high-density lipoprotein cholesterol (HDL-C) values. 33 patients with AAA and 34 patients with AOD were included in this study. There was no difference in the level of plasma CTSS between the two analysed groups (p=0.833). In the patients with AAA, the plasma CTSS was correlated with HDL-C (r =-0.377, p = 0.034) and total bilirubin (r =0.500, p = 0.003) while, unexpectedly, it was not correlated with cystatin C (Cys C) (r =0.083, p = 0.652). In the patients with AOD, the plasma CTSS correlated with triglycerides (r = 0.597, p< 0.001), only. When the patients were divided according to HDL-C (with HDL-C ≤0.90 and HDL-C >0.90 mmol/L), the plasma CTSS values differed among these groups (31.27 vs.25.61 μg/L, respectively, p<0.001). These results provide the first evidence that CTSS negatively correlated with HDL-C and bilirubin in patients with AAA. It is possible that differences in the association of the CTSS and other markers of atherosclerosis can determine whether atherosclerotic aorta will develop dilatation or stenosis.
PB  - De Gruyter Open
T2  - Journal of Medical Biochemistry
T1  - Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms
VL  - 28
IS  - 3
SP  - 268
EP  - 275
DO  - 10.2478/jomb-2018-0039
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Vasović, Novak and Černe, Darko and Kos, Janko and Bogavac-Stanojević, Nataša",
year = "2019",
abstract = "Cathepsin S (CTSS) is a cysteine protease involved in atherogenesis. We compared the plasma CTSS as well as other biomarkers of atherosclerosis in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD), aiming to identify the underlying pathogenic mechanisms of the disease development. Also, we hypothesised that the level of plasma CTSS simultaneously increases with a decrease of plasma high-density lipoprotein cholesterol (HDL-C) values. 33 patients with AAA and 34 patients with AOD were included in this study. There was no difference in the level of plasma CTSS between the two analysed groups (p=0.833). In the patients with AAA, the plasma CTSS was correlated with HDL-C (r =-0.377, p = 0.034) and total bilirubin (r =0.500, p = 0.003) while, unexpectedly, it was not correlated with cystatin C (Cys C) (r =0.083, p = 0.652). In the patients with AOD, the plasma CTSS correlated with triglycerides (r = 0.597, p< 0.001), only. When the patients were divided according to HDL-C (with HDL-C ≤0.90 and HDL-C >0.90 mmol/L), the plasma CTSS values differed among these groups (31.27 vs.25.61 μg/L, respectively, p<0.001). These results provide the first evidence that CTSS negatively correlated with HDL-C and bilirubin in patients with AAA. It is possible that differences in the association of the CTSS and other markers of atherosclerosis can determine whether atherosclerotic aorta will develop dilatation or stenosis.",
publisher = "De Gruyter Open",
journal = "Journal of Medical Biochemistry",
title = "Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms",
volume = "28",
number = "3",
pages = "268-275",
doi = "10.2478/jomb-2018-0039"
}

Mirjanić-Azarić, B., Vasović, N., Černe, D., Kos, J.,& Bogavac-Stanojević, N.. (2019). Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms. in Journal of Medical Biochemistry
De Gruyter Open., 28(3), 268-275.
https://doi.org/10.2478/jomb-2018-0039

Mirjanić-Azarić B, Vasović N, Černe D, Kos J, Bogavac-Stanojević N. Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms. in Journal of Medical Biochemistry. 2019;28(3):268-275.
doi:10.2478/jomb-2018-0039 .

Mirjanić-Azarić, Bosa, Vasović, Novak, Černe, Darko, Kos, Janko, Bogavac-Stanojević, Nataša, "Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms" in Journal of Medical Biochemistry, 28, no. 3 (2019):268-275,
https://doi.org/10.2478/jomb-2018-0039 . .

TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Vasić, Novak
AU  - Cerne, Darko
AU  - Kos, Janko
AU  - Bogavac-Stanojević, Nataša
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3338
AB  - Background: Cathepsin S (CTSS) is a cysteine protease involved in atherogenesis. We compared the plasma CTSS as well as other biomarkers of atherosclerosis in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD), aiming to identify the underlying pathogenic mechanisms of the disease development. Also, we hypothesised that the level of plasma CTSS simultaneously increases with a decrease of plasma high-density lipoprotein cholesterol (HDL-C) values. Methods: 33 patients with AAA and 34 patients with AOD were included in this study. Results: There was no difference in the level of plasma CTSS between the two analysed groups (p=0.833). In the patients with AAA, the plasma CTSS was correlated with HDL-C (r = -0.377, p = 0.034) and total bilirubin (r = 0.500, p = 0.003) while, unexpectedly, it was not correlated with cystatin C (Cys C) (r = 0.083, p = 0.652). In the patients with AOD, the plasma CTSS correlated with triglycerides (r = 0.597, p  lt  0.001), only. When the patients were divided according to HDL-C (with HDL-C  lt = 0.90 and HDL-C >0.90 mmol/L), the plasma CTSS values differed among these groups (31.27 vs.25.61 mu g/L, respectively, p lt 0.001). Conclusions: These results provide the first evidence that CTSS negatively correlated with HDL-C and bilirubin in patients with AAA. It is possible that differences in the association of the CTSS and other markers of atherosclerosis can determine whether atherosclerotic aorta will develop dilatation or stenosis.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms
VL  - 38
IS  - 3
SP  - 268
EP  - 275
DO  - 10.2478/jomb-2018-0039
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Vasić, Novak and Cerne, Darko and Kos, Janko and Bogavac-Stanojević, Nataša",
year = "2019",
abstract = "Background: Cathepsin S (CTSS) is a cysteine protease involved in atherogenesis. We compared the plasma CTSS as well as other biomarkers of atherosclerosis in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD), aiming to identify the underlying pathogenic mechanisms of the disease development. Also, we hypothesised that the level of plasma CTSS simultaneously increases with a decrease of plasma high-density lipoprotein cholesterol (HDL-C) values. Methods: 33 patients with AAA and 34 patients with AOD were included in this study. Results: There was no difference in the level of plasma CTSS between the two analysed groups (p=0.833). In the patients with AAA, the plasma CTSS was correlated with HDL-C (r = -0.377, p = 0.034) and total bilirubin (r = 0.500, p = 0.003) while, unexpectedly, it was not correlated with cystatin C (Cys C) (r = 0.083, p = 0.652). In the patients with AOD, the plasma CTSS correlated with triglycerides (r = 0.597, p  lt  0.001), only. When the patients were divided according to HDL-C (with HDL-C  lt = 0.90 and HDL-C >0.90 mmol/L), the plasma CTSS values differed among these groups (31.27 vs.25.61 mu g/L, respectively, p lt 0.001). Conclusions: These results provide the first evidence that CTSS negatively correlated with HDL-C and bilirubin in patients with AAA. It is possible that differences in the association of the CTSS and other markers of atherosclerosis can determine whether atherosclerotic aorta will develop dilatation or stenosis.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms",
volume = "38",
number = "3",
pages = "268-275",
doi = "10.2478/jomb-2018-0039"
}

Mirjanić-Azarić, B., Vasić, N., Cerne, D., Kos, J.,& Bogavac-Stanojević, N.. (2019). Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(3), 268-275.
https://doi.org/10.2478/jomb-2018-0039

Mirjanić-Azarić B, Vasić N, Cerne D, Kos J, Bogavac-Stanojević N. Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms. in Journal of Medical Biochemistry. 2019;38(3):268-275.
doi:10.2478/jomb-2018-0039 .

Mirjanić-Azarić, Bosa, Vasić, Novak, Cerne, Darko, Kos, Janko, Bogavac-Stanojević, Nataša, "Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms" in Journal of Medical Biochemistry, 38, no. 3 (2019):268-275,
https://doi.org/10.2478/jomb-2018-0039 . .

TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Đerić, Mirjana
AU  - Milivojac, Tatjana
AU  - Fonović, Ursa Pecar
AU  - Marc, Janja
AU  - Kos, Janko
AU  - Cerne, Darko
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2069
AB  - Aim: We hypothesized that, in stable angina patients, atorvastatin therapy lowers the cathepsin S (CTSS) concentrations, as assessed non-invasively according to a plasma analysis. In addition, the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in the plasma were analysed to establish the association between CTSS and lipoprotein metabolism and determine whether this association is atorvastatin-sensitive. Methods: A total of 43 patients with stable angina received atorvastatin therapy (20 mg/day, 10 weeks). The plasma CTSS mRNA levels, CTSS protein concentrations and CTSS activity, as well as LDL and HDL size and subclasses, were analysed before and after treatment. Results: Atorvastatin treatment did not change the plasma CTSS mRNA levels, although it lowered the plasma CTSS concentrations and activity. An increased plasma CTSS concentration and activity were found to be associated with a more atherogenic LDL subclass profile (a decreased dominant LDL size and increased percentage of small, dense LDL particles). The atorvastatin-induced CTSS-lowering effect was concomitant with an improvement in the LDL subclass profile, and the changes were found to be interrelated. Concomitant, interrelated changes in the CTSS levels and LDL subclass profiles were found in the LDL phenotype B patients only (a dominant LDL diameter of  lt = 25.5 nm at the start of the study). In this subgroup, lowering of the plasma CTSS mRNA level also correlated with lowering of the proportion of small, dense LDL particles. Conclusions: Atorvastatin-induced CTSS-lowering and LDL subclass profile improvements in the plasma of LDL phenotype B patients with stable angina are concomitant and interrelated.
PB  - Japan Atherosclerosis Soc, Tokyo
T2  - Journal of Atherosclerosis and Thrombosis
T1  - Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients
VL  - 21
IS  - 8
SP  - 868
EP  - 877
DO  - 10.5551/jat.21410
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Đerić, Mirjana and Milivojac, Tatjana and Fonović, Ursa Pecar and Marc, Janja and Kos, Janko and Cerne, Darko",
year = "2014",
abstract = "Aim: We hypothesized that, in stable angina patients, atorvastatin therapy lowers the cathepsin S (CTSS) concentrations, as assessed non-invasively according to a plasma analysis. In addition, the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in the plasma were analysed to establish the association between CTSS and lipoprotein metabolism and determine whether this association is atorvastatin-sensitive. Methods: A total of 43 patients with stable angina received atorvastatin therapy (20 mg/day, 10 weeks). The plasma CTSS mRNA levels, CTSS protein concentrations and CTSS activity, as well as LDL and HDL size and subclasses, were analysed before and after treatment. Results: Atorvastatin treatment did not change the plasma CTSS mRNA levels, although it lowered the plasma CTSS concentrations and activity. An increased plasma CTSS concentration and activity were found to be associated with a more atherogenic LDL subclass profile (a decreased dominant LDL size and increased percentage of small, dense LDL particles). The atorvastatin-induced CTSS-lowering effect was concomitant with an improvement in the LDL subclass profile, and the changes were found to be interrelated. Concomitant, interrelated changes in the CTSS levels and LDL subclass profiles were found in the LDL phenotype B patients only (a dominant LDL diameter of  lt = 25.5 nm at the start of the study). In this subgroup, lowering of the plasma CTSS mRNA level also correlated with lowering of the proportion of small, dense LDL particles. Conclusions: Atorvastatin-induced CTSS-lowering and LDL subclass profile improvements in the plasma of LDL phenotype B patients with stable angina are concomitant and interrelated.",
publisher = "Japan Atherosclerosis Soc, Tokyo",
journal = "Journal of Atherosclerosis and Thrombosis",
title = "Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients",
volume = "21",
number = "8",
pages = "868-877",
doi = "10.5551/jat.21410"
}

Mirjanić-Azarić, B., Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Đerić, M., Milivojac, T., Fonović, U. P., Marc, J., Kos, J.,& Cerne, D.. (2014). Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients. in Journal of Atherosclerosis and Thrombosis
Japan Atherosclerosis Soc, Tokyo., 21(8), 868-877.
https://doi.org/10.5551/jat.21410

Mirjanić-Azarić B, Vekić J, Zeljković A, Jelić-Ivanović Z, Đerić M, Milivojac T, Fonović UP, Marc J, Kos J, Cerne D. Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients. in Journal of Atherosclerosis and Thrombosis. 2014;21(8):868-877.
doi:10.5551/jat.21410 .

Mirjanić-Azarić, Bosa, Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Đerić, Mirjana, Milivojac, Tatjana, Fonović, Ursa Pecar, Marc, Janja, Kos, Janko, Cerne, Darko, "Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients" in Journal of Atherosclerosis and Thrombosis, 21, no. 8 (2014):868-877,
https://doi.org/10.5551/jat.21410 . .