TY  - JOUR
AU  - Vukicević, Petar
AU  - Mikić, Aleksandar
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Milić, Nataša
AU  - Nikolić, Ljubinka
AU  - Martinović, Jelena
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2621
AB  - This study aimed to evaluate the oxidative stress status and two markers of platelet activation and reactivity in off-pump versus on-pump coronary artery bypass surgery. Study groups of 65 patients with double coronary artery bypass grafting were divided into cardiopulmonary bypass (CPB) and off-pump coronary artery bypass groups. In serial blood samples, lipid hydroperoxides (LOOH), serum paraoxonase (PON1), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG) and red blood cell distribution width (RDW) to platelet (Plt) ratio (RPR) and mean platelet volume (MPV) to platelet (Plt) ratio (MPR) index were determined to compare the extent of oxidative stress and platelet activation. The MPR and RPR rose significantly in the post-operative period (P  lt  0.001) in both groups. The increase was higher in the CPB group, but this difference reached borderline significance at 48 h post-operatively. The AOPP/tSHG index increased 6 h after surgery, preceded by a significant fall of the PON1/LOOH ratio, more evident in the CPB group. Multiple linear regression analysis showed explicit connection between these markers and surgery-related clinical conditions. Receiver operating characteristic analysis enabled estimation of the clinical accuracy of oxidative plus platelet-related indices in prediction of surgery caused complications (area under the curve for the model consisted of oxidative stress parameters and platelet activation indices was above 0.9, P  lt  0.001). Results showed higher oxidative stress and undesirable platelet activation in the CPB group. Oxidative status markers and platelet activity indices showed good clinical accuracy to predict the development of possible surgical complications.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Biotechnology & Biotechnological Equipment
T1  - Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels
VL  - 30
IS  - 6
SP  - 1132
EP  - 1141
DO  - 10.1080/13102818.2016.1217168
ER  - 

@article{
author = "Vukicević, Petar and Mikić, Aleksandar and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Milić, Nataša and Nikolić, Ljubinka and Martinović, Jelena",
year = "2016",
abstract = "This study aimed to evaluate the oxidative stress status and two markers of platelet activation and reactivity in off-pump versus on-pump coronary artery bypass surgery. Study groups of 65 patients with double coronary artery bypass grafting were divided into cardiopulmonary bypass (CPB) and off-pump coronary artery bypass groups. In serial blood samples, lipid hydroperoxides (LOOH), serum paraoxonase (PON1), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG) and red blood cell distribution width (RDW) to platelet (Plt) ratio (RPR) and mean platelet volume (MPV) to platelet (Plt) ratio (MPR) index were determined to compare the extent of oxidative stress and platelet activation. The MPR and RPR rose significantly in the post-operative period (P  lt  0.001) in both groups. The increase was higher in the CPB group, but this difference reached borderline significance at 48 h post-operatively. The AOPP/tSHG index increased 6 h after surgery, preceded by a significant fall of the PON1/LOOH ratio, more evident in the CPB group. Multiple linear regression analysis showed explicit connection between these markers and surgery-related clinical conditions. Receiver operating characteristic analysis enabled estimation of the clinical accuracy of oxidative plus platelet-related indices in prediction of surgery caused complications (area under the curve for the model consisted of oxidative stress parameters and platelet activation indices was above 0.9, P  lt  0.001). Results showed higher oxidative stress and undesirable platelet activation in the CPB group. Oxidative status markers and platelet activity indices showed good clinical accuracy to predict the development of possible surgical complications.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Biotechnology & Biotechnological Equipment",
title = "Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels",
volume = "30",
number = "6",
pages = "1132-1141",
doi = "10.1080/13102818.2016.1217168"
}

Vukicević, P., Mikić, A., Kotur-Stevuljević, J., Bogavac-Stanojević, N., Milić, N., Nikolić, L.,& Martinović, J.. (2016). Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels. in Biotechnology & Biotechnological Equipment
Taylor & Francis Ltd, Abingdon., 30(6), 1132-1141.
https://doi.org/10.1080/13102818.2016.1217168

Vukicević P, Mikić A, Kotur-Stevuljević J, Bogavac-Stanojević N, Milić N, Nikolić L, Martinović J. Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels. in Biotechnology & Biotechnological Equipment. 2016;30(6):1132-1141.
doi:10.1080/13102818.2016.1217168 .

Vukicević, Petar, Mikić, Aleksandar, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Milić, Nataša, Nikolić, Ljubinka, Martinović, Jelena, "Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels" in Biotechnology & Biotechnological Equipment, 30, no. 6 (2016):1132-1141,
https://doi.org/10.1080/13102818.2016.1217168 . .