TY  - JOUR
AU  - Vukicević, Petar
AU  - Mikić, Aleksandar
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Milić, Nataša
AU  - Nikolić, Ljubinka
AU  - Martinović, Jelena
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2621
AB  - This study aimed to evaluate the oxidative stress status and two markers of platelet activation and reactivity in off-pump versus on-pump coronary artery bypass surgery. Study groups of 65 patients with double coronary artery bypass grafting were divided into cardiopulmonary bypass (CPB) and off-pump coronary artery bypass groups. In serial blood samples, lipid hydroperoxides (LOOH), serum paraoxonase (PON1), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG) and red blood cell distribution width (RDW) to platelet (Plt) ratio (RPR) and mean platelet volume (MPV) to platelet (Plt) ratio (MPR) index were determined to compare the extent of oxidative stress and platelet activation. The MPR and RPR rose significantly in the post-operative period (P  lt  0.001) in both groups. The increase was higher in the CPB group, but this difference reached borderline significance at 48 h post-operatively. The AOPP/tSHG index increased 6 h after surgery, preceded by a significant fall of the PON1/LOOH ratio, more evident in the CPB group. Multiple linear regression analysis showed explicit connection between these markers and surgery-related clinical conditions. Receiver operating characteristic analysis enabled estimation of the clinical accuracy of oxidative plus platelet-related indices in prediction of surgery caused complications (area under the curve for the model consisted of oxidative stress parameters and platelet activation indices was above 0.9, P  lt  0.001). Results showed higher oxidative stress and undesirable platelet activation in the CPB group. Oxidative status markers and platelet activity indices showed good clinical accuracy to predict the development of possible surgical complications.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Biotechnology & Biotechnological Equipment
T1  - Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels
VL  - 30
IS  - 6
SP  - 1132
EP  - 1141
DO  - 10.1080/13102818.2016.1217168
ER  - 

@article{
author = "Vukicević, Petar and Mikić, Aleksandar and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Milić, Nataša and Nikolić, Ljubinka and Martinović, Jelena",
year = "2016",
abstract = "This study aimed to evaluate the oxidative stress status and two markers of platelet activation and reactivity in off-pump versus on-pump coronary artery bypass surgery. Study groups of 65 patients with double coronary artery bypass grafting were divided into cardiopulmonary bypass (CPB) and off-pump coronary artery bypass groups. In serial blood samples, lipid hydroperoxides (LOOH), serum paraoxonase (PON1), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG) and red blood cell distribution width (RDW) to platelet (Plt) ratio (RPR) and mean platelet volume (MPV) to platelet (Plt) ratio (MPR) index were determined to compare the extent of oxidative stress and platelet activation. The MPR and RPR rose significantly in the post-operative period (P  lt  0.001) in both groups. The increase was higher in the CPB group, but this difference reached borderline significance at 48 h post-operatively. The AOPP/tSHG index increased 6 h after surgery, preceded by a significant fall of the PON1/LOOH ratio, more evident in the CPB group. Multiple linear regression analysis showed explicit connection between these markers and surgery-related clinical conditions. Receiver operating characteristic analysis enabled estimation of the clinical accuracy of oxidative plus platelet-related indices in prediction of surgery caused complications (area under the curve for the model consisted of oxidative stress parameters and platelet activation indices was above 0.9, P  lt  0.001). Results showed higher oxidative stress and undesirable platelet activation in the CPB group. Oxidative status markers and platelet activity indices showed good clinical accuracy to predict the development of possible surgical complications.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Biotechnology & Biotechnological Equipment",
title = "Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels",
volume = "30",
number = "6",
pages = "1132-1141",
doi = "10.1080/13102818.2016.1217168"
}

Vukicević, P., Mikić, A., Kotur-Stevuljević, J., Bogavac-Stanojević, N., Milić, N., Nikolić, L.,& Martinović, J.. (2016). Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels. in Biotechnology & Biotechnological Equipment
Taylor & Francis Ltd, Abingdon., 30(6), 1132-1141.
https://doi.org/10.1080/13102818.2016.1217168

Vukicević P, Mikić A, Kotur-Stevuljević J, Bogavac-Stanojević N, Milić N, Nikolić L, Martinović J. Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels. in Biotechnology & Biotechnological Equipment. 2016;30(6):1132-1141.
doi:10.1080/13102818.2016.1217168 .

Vukicević, Petar, Mikić, Aleksandar, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Milić, Nataša, Nikolić, Ljubinka, Martinović, Jelena, "Oxidative stress and platelet activation during on-pump and off-pump coronary artery bypass grafting in patients with double grafted vessels" in Biotechnology & Biotechnological Equipment, 30, no. 6 (2016):1132-1141,
https://doi.org/10.1080/13102818.2016.1217168 . .

TY  - JOUR
AU  - Đunić, Irena
AU  - Dopsaj, Violeta
AU  - Miljić, Predrag
AU  - Savić, Nebojša
AU  - Milić, Nataša
AU  - Mitrović, Mirjana
AU  - Suvajdžić-Vuković, Nada
AU  - Tomin, Dragica
AU  - Elezović, Ivo
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2082
AB  - Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia
VL  - 60
IS  - 8
SP  - 1325
EP  - 1331
DO  - 10.7754/Clin.Lab.2013.130817
ER  - 

@article{
author = "Đunić, Irena and Dopsaj, Violeta and Miljić, Predrag and Savić, Nebojša and Milić, Nataša and Mitrović, Mirjana and Suvajdžić-Vuković, Nada and Tomin, Dragica and Elezović, Ivo",
year = "2014",
abstract = "Background: The goal of this study was to compare the validity of two laboratory assays, rotation thromboelastometry (ROTEM) and endogenous thrombin potential (ETP), in monitoring and evaluating different prophylactic treatment regimens in patients with severe haemophilia. Methods: Twenty adult patients with severe haemophilia were divided into three groups according to treatment regimen with concentrate of factor (F) VIII/IX: full-dose prophylaxis (5 patients), intermediate-dose prophylaxis (5 patients), and on demand treatment (10 patients). Results: The ROTEM for the group treated with full-dose prophylaxis was significantly lower than ROTEM for the group treated with intermediate-dose prophylaxis (p = 0.025). Among the patients given full-dose prophylaxis, 40% (2 patients) had prolonged ROTEM after 3 months of treatment, while among those given intermediate-dose prophylaxis all patients (100%, 5 patients) had prolonged ROTEM (p = 0.038). The ETP was significantly improved after 3 months of full-dose in comparison with intermediate-dose prophylaxis (p = 0.042). Conclusions: ROTEM and ETP are useful laboratory assays for monitoring efficacy of different prophylaxis regimens with concentrate of FVIII/IX in patients with severe haemophilia, helping in making decisions regarding optimal dose-regimen prophylaxis.",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia",
volume = "60",
number = "8",
pages = "1325-1331",
doi = "10.7754/Clin.Lab.2013.130817"
}

Đunić, I., Dopsaj, V., Miljić, P., Savić, N., Milić, N., Mitrović, M., Suvajdžić-Vuković, N., Tomin, D.,& Elezović, I.. (2014). Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 60(8), 1325-1331.
https://doi.org/10.7754/Clin.Lab.2013.130817

Đunić I, Dopsaj V, Miljić P, Savić N, Milić N, Mitrović M, Suvajdžić-Vuković N, Tomin D, Elezović I. Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia. in Clinical Laboratory. 2014;60(8):1325-1331.
doi:10.7754/Clin.Lab.2013.130817 .

Đunić, Irena, Dopsaj, Violeta, Miljić, Predrag, Savić, Nebojša, Milić, Nataša, Mitrović, Mirjana, Suvajdžić-Vuković, Nada, Tomin, Dragica, Elezović, Ivo, "Comparison of Two Laboratory Assays in Monitoring the Efficacy of Different Prophylaxis Regimens for Severe Haemophilia" in Clinical Laboratory, 60, no. 8 (2014):1325-1331,
https://doi.org/10.7754/Clin.Lab.2013.130817 . .

TY  - CONF
AU  - Đunić, Irena
AU  - Dopsaj, Violeta
AU  - Savić, N.
AU  - Miljić, Predrag
AU  - Milić, Nataša
AU  - Tomin, Dragica
AU  - Elezović, I.
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1716
PB  - Wiley-Blackwell, Hoboken
C3  - Haemophilia
T1  - Comparison of two laboratory assays in monitoring efficacy of different prophylaxis regimens for severe hemophilia
VL  - 18
SP  - 162
EP  - 162
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1716
ER  - 

@conference{
author = "Đunić, Irena and Dopsaj, Violeta and Savić, N. and Miljić, Predrag and Milić, Nataša and Tomin, Dragica and Elezović, I.",
year = "2012",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Haemophilia",
title = "Comparison of two laboratory assays in monitoring efficacy of different prophylaxis regimens for severe hemophilia",
volume = "18",
pages = "162-162",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1716"
}

Đunić, I., Dopsaj, V., Savić, N., Miljić, P., Milić, N., Tomin, D.,& Elezović, I.. (2012). Comparison of two laboratory assays in monitoring efficacy of different prophylaxis regimens for severe hemophilia. in Haemophilia
Wiley-Blackwell, Hoboken., 18, 162-162.
https://hdl.handle.net/21.15107/rcub_farfar_1716

Đunić I, Dopsaj V, Savić N, Miljić P, Milić N, Tomin D, Elezović I. Comparison of two laboratory assays in monitoring efficacy of different prophylaxis regimens for severe hemophilia. in Haemophilia. 2012;18:162-162.
https://hdl.handle.net/21.15107/rcub_farfar_1716 .

Đunić, Irena, Dopsaj, Violeta, Savić, N., Miljić, Predrag, Milić, Nataša, Tomin, Dragica, Elezović, I., "Comparison of two laboratory assays in monitoring efficacy of different prophylaxis regimens for severe hemophilia" in Haemophilia, 18 (2012):162-162,
https://hdl.handle.net/21.15107/rcub_farfar_1716 .