TY  - JOUR
AU  - Aleksić, Ivana
AU  - Đuriš, Jelena
AU  - Ilić, Ilija
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Srcić, Stanko
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2225
AB  - Fluidized bed melt granulation has recently been recognized as a promising technique with numerous advantages over conventional granulation techniques. The aim of this study was to evaluate the possibility of using response surface methodology and artificial neural networks for optimizing in situ fluidized bed melt granulation and to compare them with regard to modeling ability and predictability. The experiments were organized in line with the Box-Behnken design. The influence of binder content, binder particle size, and granulation time on granule properties was evaluated. In addition to the response surface analysis, a multilayer perceptron neural network was applied for data modeling. It was found that in situ fluidized bed melt granulation can be used for production of spherical granules with good flowability. Binder particle size had the most pronounced influence on granule size and shape, suggesting the importance of this parameter in achieving desired granule properties. It was found that binder content can be a critical factor for the width of granule size distribution and yield when immersion and layering is the dominant agglomeration mechanism. The results obtained indicate that both in silico techniques can be useful tools in defining the design space and optimization of in situ fluidized bed melt granulation.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - In silico modeling of in situ fluidized bed melt granulation
VL  - 466
IS  - 1-2
SP  - 21
EP  - 30
DO  - 10.1016/j.ijpharm.2014.02.045
ER  - 

@article{
author = "Aleksić, Ivana and Đuriš, Jelena and Ilić, Ilija and Ibrić, Svetlana and Parojčić, Jelena and Srcić, Stanko",
year = "2014",
abstract = "Fluidized bed melt granulation has recently been recognized as a promising technique with numerous advantages over conventional granulation techniques. The aim of this study was to evaluate the possibility of using response surface methodology and artificial neural networks for optimizing in situ fluidized bed melt granulation and to compare them with regard to modeling ability and predictability. The experiments were organized in line with the Box-Behnken design. The influence of binder content, binder particle size, and granulation time on granule properties was evaluated. In addition to the response surface analysis, a multilayer perceptron neural network was applied for data modeling. It was found that in situ fluidized bed melt granulation can be used for production of spherical granules with good flowability. Binder particle size had the most pronounced influence on granule size and shape, suggesting the importance of this parameter in achieving desired granule properties. It was found that binder content can be a critical factor for the width of granule size distribution and yield when immersion and layering is the dominant agglomeration mechanism. The results obtained indicate that both in silico techniques can be useful tools in defining the design space and optimization of in situ fluidized bed melt granulation.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "In silico modeling of in situ fluidized bed melt granulation",
volume = "466",
number = "1-2",
pages = "21-30",
doi = "10.1016/j.ijpharm.2014.02.045"
}

Aleksić, I., Đuriš, J., Ilić, I., Ibrić, S., Parojčić, J.,& Srcić, S.. (2014). In silico modeling of in situ fluidized bed melt granulation. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 466(1-2), 21-30.
https://doi.org/10.1016/j.ijpharm.2014.02.045

Aleksić I, Đuriš J, Ilić I, Ibrić S, Parojčić J, Srcić S. In silico modeling of in situ fluidized bed melt granulation. in International Journal of Pharmaceutics. 2014;466(1-2):21-30.
doi:10.1016/j.ijpharm.2014.02.045 .

Aleksić, Ivana, Đuriš, Jelena, Ilić, Ilija, Ibrić, Svetlana, Parojčić, Jelena, Srcić, Stanko, "In silico modeling of in situ fluidized bed melt granulation" in International Journal of Pharmaceutics, 466, no. 1-2 (2014):21-30,
https://doi.org/10.1016/j.ijpharm.2014.02.045 . .

TY  - JOUR
AU  - Mašić, Ivana
AU  - Ilić, Ilija
AU  - Dreu, Rok
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Srcić, Stanko
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2179
AB  - Objective: The aim of this study was to investigate the influence of process parameters, binder content and binder addition method on characteristics of the granules obtained by melt granulation (MG) in fluidized bed. Methods: Spray-on experiments were performed according to 2 3 full factorial design. The effect of binder content, molten binder feed rate, and spray air pressure on granule size and size distribution, granule shape, Flowability and drug release rate was investigated. In the in situ experiments, the influence of binder particle size and binder content was evaluated. Solid-state characterization was performed by means of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy. Results: Size of the granules obtained by spray-on procedure was significantly influenced by binder content and spray air pressure, while the width of particle size distribution was mainly affected by binder feed rate. Spray air pressure showed the most significant influence on granule shape. It was shown that smooth and spherical particles with good flow properties may be obtained by both procedures, spray-on and in situ MG. The results obtained indicated the influence of agglomeration mechanism on granule sphericity, with higher degree of granule sphericity observed when immersion and layering was the dominant mechanism. Paracetamol release from granulates was very rapid, but after compression of the granules into tablets, drug release was considerably slower. Solid-state analysis confirmed that the physical form of the granulate components remained unaffected after the MG process. Conclusion: The results presented indicate that MG in fluidized bed could be a good alternative to conventional granulation techniques.
PB  - Informa Healthcare, London
T2  - Drug Development and Industrial Pharmacy
T1  - Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure
VL  - 40
IS  - 1
SP  - 23
EP  - 32
DO  - 10.3109/03639045.2012.744415
ER  - 

@article{
author = "Mašić, Ivana and Ilić, Ilija and Dreu, Rok and Ibrić, Svetlana and Parojčić, Jelena and Srcić, Stanko",
year = "2014",
abstract = "Objective: The aim of this study was to investigate the influence of process parameters, binder content and binder addition method on characteristics of the granules obtained by melt granulation (MG) in fluidized bed. Methods: Spray-on experiments were performed according to 2 3 full factorial design. The effect of binder content, molten binder feed rate, and spray air pressure on granule size and size distribution, granule shape, Flowability and drug release rate was investigated. In the in situ experiments, the influence of binder particle size and binder content was evaluated. Solid-state characterization was performed by means of differential scanning calorimetry, X-ray powder diffraction and Fourier transform infrared spectroscopy. Results: Size of the granules obtained by spray-on procedure was significantly influenced by binder content and spray air pressure, while the width of particle size distribution was mainly affected by binder feed rate. Spray air pressure showed the most significant influence on granule shape. It was shown that smooth and spherical particles with good flow properties may be obtained by both procedures, spray-on and in situ MG. The results obtained indicated the influence of agglomeration mechanism on granule sphericity, with higher degree of granule sphericity observed when immersion and layering was the dominant mechanism. Paracetamol release from granulates was very rapid, but after compression of the granules into tablets, drug release was considerably slower. Solid-state analysis confirmed that the physical form of the granulate components remained unaffected after the MG process. Conclusion: The results presented indicate that MG in fluidized bed could be a good alternative to conventional granulation techniques.",
publisher = "Informa Healthcare, London",
journal = "Drug Development and Industrial Pharmacy",
title = "Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure",
volume = "40",
number = "1",
pages = "23-32",
doi = "10.3109/03639045.2012.744415"
}

Mašić, I., Ilić, I., Dreu, R., Ibrić, S., Parojčić, J.,& Srcić, S.. (2014). Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure. in Drug Development and Industrial Pharmacy
Informa Healthcare, London., 40(1), 23-32.
https://doi.org/10.3109/03639045.2012.744415

Mašić I, Ilić I, Dreu R, Ibrić S, Parojčić J, Srcić S. Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure. in Drug Development and Industrial Pharmacy. 2014;40(1):23-32.
doi:10.3109/03639045.2012.744415 .

Mašić, Ivana, Ilić, Ilija, Dreu, Rok, Ibrić, Svetlana, Parojčić, Jelena, Srcić, Stanko, "Melt granulation in fluidized bed: a comparative study of spray-on versus in situ procedure" in Drug Development and Industrial Pharmacy, 40, no. 1 (2014):23-32,
https://doi.org/10.3109/03639045.2012.744415 . .