TY  - JOUR
AU  - Simić, Milena
AU  - Paunović, Nikola
AU  - Borić, Ivan
AU  - Ranđelović, Jelena
AU  - Vojnović, Sandra
AU  - Nikodinović-Runić, Jasmina
AU  - Pekmezović, Marina
AU  - Savić, Vladimir
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2580
AB  - A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Bioorganic & Medicinal Chemistry Letters
T1  - Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies
VL  - 26
IS  - 1
SP  - 235
EP  - 239
DO  - 10.1016/j.bmcl.2015.08.086
ER  - 

@article{
author = "Simić, Milena and Paunović, Nikola and Borić, Ivan and Ranđelović, Jelena and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Pekmezović, Marina and Savić, Vladimir",
year = "2016",
abstract = "A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Bioorganic & Medicinal Chemistry Letters",
title = "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies",
volume = "26",
number = "1",
pages = "235-239",
doi = "10.1016/j.bmcl.2015.08.086"
}

Simić, M., Paunović, N., Borić, I., Ranđelović, J., Vojnović, S., Nikodinović-Runić, J., Pekmezović, M.,& Savić, V.. (2016). Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic & Medicinal Chemistry Letters
Pergamon-Elsevier Science Ltd, Oxford., 26(1), 235-239.
https://doi.org/10.1016/j.bmcl.2015.08.086

Simić M, Paunović N, Borić I, Ranđelović J, Vojnović S, Nikodinović-Runić J, Pekmezović M, Savić V. Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic & Medicinal Chemistry Letters. 2016;26(1):235-239.
doi:10.1016/j.bmcl.2015.08.086 .

Simić, Milena, Paunović, Nikola, Borić, Ivan, Ranđelović, Jelena, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Pekmezović, Marina, Savić, Vladimir, "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies" in Bioorganic & Medicinal Chemistry Letters, 26, no. 1 (2016):235-239,
https://doi.org/10.1016/j.bmcl.2015.08.086 . .

TY  - JOUR
AU  - Janošević-Ležaić, Aleksandra
AU  - Paunović, Nikola
AU  - Pejić, Nataša
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2294
AB  - Micellization of hexadecyltrimethylammonium bromide (syn. cetyltrimethylammonium bromide, CTAB) in propylene glycol-water (30% v/v) binary mixture, as well as the thermodynamic properties of the resulting micelles, were investigated by electrical conductivity measurements. The conductivity data were used to determine both the critical micellar concentration (CMC) and the micellar ionization degree (∞) of CTAB in the temperature range 298.2-310.2 K. The equilibrium model of micelle formation was applied in order to obtain the thermodynamic parameters (the standard molar Gibbs free energy, ∆Gmº, enthalpy, ∆Hm0 and entropy, ∆Smº) of the micellization process. The values of ∆Gmº and ∆Hmº were found to be negative at all investigated temperatures, while the values of ∆Smº were positive and became more positive as temperature increased. A linear dependence between ∆Smº and ∆Hmº, i.e. an enthalpy-entropy compensation effect, was observed.
AB  - Konduktometrijski je ispitivana micelizacija heksadeciltrimetilamonijum-bromida (sinonim cetiltrimetilamonijum-bromid, CTAB) u binarnoj smeši propilen-glikol-voda (30%, v/v), kao i termodinamičke osobine nastalih micela. Merenjem specifične provodljivosti određeni su kritična micelarna koncentracija (KMK) i stepen jonizacije micele (∞) CTAB u opsegu temperatura 298,2-310,2 K određeni su. Primenom ravnotežnog modela za proces micelizacije izračunati su termodinamički parametri: promena standardne molarne Džibsove slobodne energije, (∆Gmº), entalpije (∆Hmº) i entropije (∆Smº) micelizacije. Vrednosti ∆Gmº i ∆Hmº su bile negativne na svakoj od ispitivanih temperatura, dok su vrednosti ∆Smº bile pozitivne i povećavale su se sa porastom temperature. Na osnovu linearne zavisnosti između ∆Hmº i ∆Smº utvrđen je tzv. entalpijsko-entropijski kompenzacioni efekat.
PB  - Univerzitet u Nišu, Niš
T2  - Facta universitatis - series: Physics, Chemistry and Technology
T1  - Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylene glycol-water mixture: A conductivity study
T1  - Termodinamika micelizacije heksadeciltrimetilamonijum-bromida u smeši propilen-glikol-voda - konduktometrijsko ispitivanje
VL  - 12
IS  - 1
SP  - 17
EP  - 26
DO  - 10.2298/FUPCT1401017J
ER  - 

@article{
author = "Janošević-Ležaić, Aleksandra and Paunović, Nikola and Pejić, Nataša",
year = "2014",
abstract = "Micellization of hexadecyltrimethylammonium bromide (syn. cetyltrimethylammonium bromide, CTAB) in propylene glycol-water (30% v/v) binary mixture, as well as the thermodynamic properties of the resulting micelles, were investigated by electrical conductivity measurements. The conductivity data were used to determine both the critical micellar concentration (CMC) and the micellar ionization degree (∞) of CTAB in the temperature range 298.2-310.2 K. The equilibrium model of micelle formation was applied in order to obtain the thermodynamic parameters (the standard molar Gibbs free energy, ∆Gmº, enthalpy, ∆Hm0 and entropy, ∆Smº) of the micellization process. The values of ∆Gmº and ∆Hmº were found to be negative at all investigated temperatures, while the values of ∆Smº were positive and became more positive as temperature increased. A linear dependence between ∆Smº and ∆Hmº, i.e. an enthalpy-entropy compensation effect, was observed., Konduktometrijski je ispitivana micelizacija heksadeciltrimetilamonijum-bromida (sinonim cetiltrimetilamonijum-bromid, CTAB) u binarnoj smeši propilen-glikol-voda (30%, v/v), kao i termodinamičke osobine nastalih micela. Merenjem specifične provodljivosti određeni su kritična micelarna koncentracija (KMK) i stepen jonizacije micele (∞) CTAB u opsegu temperatura 298,2-310,2 K određeni su. Primenom ravnotežnog modela za proces micelizacije izračunati su termodinamički parametri: promena standardne molarne Džibsove slobodne energije, (∆Gmº), entalpije (∆Hmº) i entropije (∆Smº) micelizacije. Vrednosti ∆Gmº i ∆Hmº su bile negativne na svakoj od ispitivanih temperatura, dok su vrednosti ∆Smº bile pozitivne i povećavale su se sa porastom temperature. Na osnovu linearne zavisnosti između ∆Hmº i ∆Smº utvrđen je tzv. entalpijsko-entropijski kompenzacioni efekat.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Physics, Chemistry and Technology",
title = "Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylene glycol-water mixture: A conductivity study, Termodinamika micelizacije heksadeciltrimetilamonijum-bromida u smeši propilen-glikol-voda - konduktometrijsko ispitivanje",
volume = "12",
number = "1",
pages = "17-26",
doi = "10.2298/FUPCT1401017J"
}

Janošević-Ležaić, A., Paunović, N.,& Pejić, N.. (2014). Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylene glycol-water mixture: A conductivity study. in Facta universitatis - series: Physics, Chemistry and Technology
Univerzitet u Nišu, Niš., 12(1), 17-26.
https://doi.org/10.2298/FUPCT1401017J

Janošević-Ležaić A, Paunović N, Pejić N. Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylene glycol-water mixture: A conductivity study. in Facta universitatis - series: Physics, Chemistry and Technology. 2014;12(1):17-26.
doi:10.2298/FUPCT1401017J .

Janošević-Ležaić, Aleksandra, Paunović, Nikola, Pejić, Nataša, "Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylene glycol-water mixture: A conductivity study" in Facta universitatis - series: Physics, Chemistry and Technology, 12, no. 1 (2014):17-26,
https://doi.org/10.2298/FUPCT1401017J . .

TY  - JOUR
AU  - Pejić, Nataša
AU  - Janošević, Aleksandra
AU  - Rogić, Jelica
AU  - Paunović, Nikola
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1804
AB  - The effect of cosolvent (propylen glycol, PG) on micellization of an cationic surfactant, hexadecyltrimethylammonium bromide (hereinafter cetylecyltrimethylammonium bromide, CTAB) in aqueous solution was studied. The thermodynamic of micellization and the aggregation behaviour of CTAB in PG-water mixture at different temperatures (from 298.2 K to 310.2 K) have been studied conductometrically. The conductivity data were used to determine the critical micellar concentration (CMC) and degree of micellar ionization (α) of CTAB in PG-water (20% v/v) binary mixtures at different temperatures (298.2 K, 306.2 K and 310.2 K). The equilibrium model of micelle formation was applied to obtain the thermodynamics parameters (the standard molar Gibs free energy (ΔGm 0), enthalpy (ΔHm 0) and entropy (ΔSm 0)) of micellization. Those parameters were determined using temperature dependance of CMC. Value of DGm 0 was found to be negative at all temperatures and becomes less negative as the temperature increases. Values of ΔHm 0 and ΔSm 0 were found to be negative in all cases, and increase dramaticaly with temperature in 20 % (v/v) PG. An entalpy-entropy compenzation effect was observed. Moreover, based on experimental data, it can be concluded that the micellization process in the examined system is substantially similar to the CTAB micellization in water, and the presence of PG has a negligible effect on the CTAB-water interactions.
AB  - U radu je ispitan uticaj korastvarača (propilenglikola, PG) na micelizaciju katjonskog surfaktanta, heksadeciltrimetilamonijum-bromida (cetiltrimetilamonijum-bromida, CTAB) u vodenom rastvoru. Termodinamika micelizacije i agregaciono ponašanje CTAB u smeši PG-voda na različitim temperaturama (od 298,2 K do 310,2 K) ispitivani su konduktometrijski. Kritična micelarna koncentracija (KMK) i stepen jonizacije micele (α) CTAB u smeši PG-voda (20% (v/v)), na različitim temperaturama (298,2 K, 306,2 K i 310,2 K) određeni su merenjem specifične provodljivosti. Primenom ravnotežnog modela za proces formiranja micela i iz temperaturne zavisnosti KMK, izračunati su termodinamički parametri (promena standardne molarne Gibsove slobodne energije, (Δm 0), entalpije (ΔHm 0) i entropije (ΔSm 0)) micelizacije. Vrednost DGm 0 je negativna na svakoj od ispitivanih temperatura; ove vrednosti se smanjuju po apsolutnoj vrednosti sa povećanjem temperature. Vrednosti ΔHm 0 i ΔSm 0 su negativne na svakoj od ispitivanih temperatura i drastično se povećavaju po apsolutnoj vrednosti sa povećanjem temperature u smeši PG-voda. Za proces micelizacije CTAB u smeši PG-voda (20% (v/v)), dobijen je tzv. entalpijsko-entropijski kompenzacioni efekat. Štaviše, na osnovu eksperimentalno dobijenih podataka može se zaključiti da je proces micelizacije u ispitivanom sistemu suštinski sličan micelizaciji CTAB u vodi, i da prisustvo PG ima neznatan uticaj na interakcije između CTAB i vode.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylen glycol-water binary mixture
T1  - Termodinamika micelizacije heksadeciltrimetilamonijum-bromida u binarnoj smeši propilenglikol-voda
VL  - 62
IS  - 5
SP  - 429
EP  - 442
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1804
ER  - 

@article{
author = "Pejić, Nataša and Janošević, Aleksandra and Rogić, Jelica and Paunović, Nikola",
year = "2012",
abstract = "The effect of cosolvent (propylen glycol, PG) on micellization of an cationic surfactant, hexadecyltrimethylammonium bromide (hereinafter cetylecyltrimethylammonium bromide, CTAB) in aqueous solution was studied. The thermodynamic of micellization and the aggregation behaviour of CTAB in PG-water mixture at different temperatures (from 298.2 K to 310.2 K) have been studied conductometrically. The conductivity data were used to determine the critical micellar concentration (CMC) and degree of micellar ionization (α) of CTAB in PG-water (20% v/v) binary mixtures at different temperatures (298.2 K, 306.2 K and 310.2 K). The equilibrium model of micelle formation was applied to obtain the thermodynamics parameters (the standard molar Gibs free energy (ΔGm 0), enthalpy (ΔHm 0) and entropy (ΔSm 0)) of micellization. Those parameters were determined using temperature dependance of CMC. Value of DGm 0 was found to be negative at all temperatures and becomes less negative as the temperature increases. Values of ΔHm 0 and ΔSm 0 were found to be negative in all cases, and increase dramaticaly with temperature in 20 % (v/v) PG. An entalpy-entropy compenzation effect was observed. Moreover, based on experimental data, it can be concluded that the micellization process in the examined system is substantially similar to the CTAB micellization in water, and the presence of PG has a negligible effect on the CTAB-water interactions., U radu je ispitan uticaj korastvarača (propilenglikola, PG) na micelizaciju katjonskog surfaktanta, heksadeciltrimetilamonijum-bromida (cetiltrimetilamonijum-bromida, CTAB) u vodenom rastvoru. Termodinamika micelizacije i agregaciono ponašanje CTAB u smeši PG-voda na različitim temperaturama (od 298,2 K do 310,2 K) ispitivani su konduktometrijski. Kritična micelarna koncentracija (KMK) i stepen jonizacije micele (α) CTAB u smeši PG-voda (20% (v/v)), na različitim temperaturama (298,2 K, 306,2 K i 310,2 K) određeni su merenjem specifične provodljivosti. Primenom ravnotežnog modela za proces formiranja micela i iz temperaturne zavisnosti KMK, izračunati su termodinamički parametri (promena standardne molarne Gibsove slobodne energije, (Δm 0), entalpije (ΔHm 0) i entropije (ΔSm 0)) micelizacije. Vrednost DGm 0 je negativna na svakoj od ispitivanih temperatura; ove vrednosti se smanjuju po apsolutnoj vrednosti sa povećanjem temperature. Vrednosti ΔHm 0 i ΔSm 0 su negativne na svakoj od ispitivanih temperatura i drastično se povećavaju po apsolutnoj vrednosti sa povećanjem temperature u smeši PG-voda. Za proces micelizacije CTAB u smeši PG-voda (20% (v/v)), dobijen je tzv. entalpijsko-entropijski kompenzacioni efekat. Štaviše, na osnovu eksperimentalno dobijenih podataka može se zaključiti da je proces micelizacije u ispitivanom sistemu suštinski sličan micelizaciji CTAB u vodi, i da prisustvo PG ima neznatan uticaj na interakcije između CTAB i vode.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylen glycol-water binary mixture, Termodinamika micelizacije heksadeciltrimetilamonijum-bromida u binarnoj smeši propilenglikol-voda",
volume = "62",
number = "5",
pages = "429-442",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1804"
}

Pejić, N., Janošević, A., Rogić, J.,& Paunović, N.. (2012). Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylen glycol-water binary mixture. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 62(5), 429-442.
https://hdl.handle.net/21.15107/rcub_farfar_1804

Pejić N, Janošević A, Rogić J, Paunović N. Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylen glycol-water binary mixture. in Arhiv za farmaciju. 2012;62(5):429-442.
https://hdl.handle.net/21.15107/rcub_farfar_1804 .

Pejić, Nataša, Janošević, Aleksandra, Rogić, Jelica, Paunović, Nikola, "Thermodynamics of micellization of hexadecyltrimethylammonium bromide in propylen glycol-water binary mixture" in Arhiv za farmaciju, 62, no. 5 (2012):429-442,
https://hdl.handle.net/21.15107/rcub_farfar_1804 .