TY  - JOUR
AU  - Pejić, Nataša
AU  - Blagojević, Slavica
AU  - Sarap, Nataša B.
AU  - Maksimović, Jelena
AU  - Anić, Slobodan
AU  - Čupić, Željko
AU  - Kolar-Anić, Ljiljana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2172
AB  - Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Helvetica Chimica Acta
T1  - Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations
VL  - 97
IS  - 1
SP  - 47
EP  - 55
DO  - 10.1002/hlca.201300109
ER  - 

@article{
author = "Pejić, Nataša and Blagojević, Slavica and Sarap, Nataša B. and Maksimović, Jelena and Anić, Slobodan and Čupić, Željko and Kolar-Anić, Ljiljana",
year = "2014",
abstract = "Perturbation of the BrayLiebhafsky non-oscillating subsystem (mixture of KIO3 and H2SO4), i.e., Dushman reaction (DR), by piroxicam (PX), was observed in an open reactor, i.e., in the continuously fed well-stirred tank reactor (CSTR). Monitoring the response of DR to perturbations by different concentrations of PX allows developing a simple procedure for quantitative determination of this analyte in both bulk drug and pharmaceutical preparation (injection). A tentative perturbation mechanism of PX action on the DR matrix, based on a kinetic scheme that was suggested by Agreda etal., is proposed. The PX reactivity in DR has been generally related to the reaction of PX with hypoiodous acid (HIO) present in the matrix.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Helvetica Chimica Acta",
title = "Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations",
volume = "97",
number = "1",
pages = "47-55",
doi = "10.1002/hlca.201300109"
}

Pejić, N., Blagojević, S., Sarap, N. B., Maksimović, J., Anić, S., Čupić, Ž.,& Kolar-Anić, L.. (2014). Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations. in Helvetica Chimica Acta
Wiley-VCH Verlag GMBH, Weinheim., 97(1), 47-55.
https://doi.org/10.1002/hlca.201300109

Pejić N, Blagojević S, Sarap NB, Maksimović J, Anić S, Čupić Ž, Kolar-Anić L. Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations. in Helvetica Chimica Acta. 2014;97(1):47-55.
doi:10.1002/hlca.201300109 .

Pejić, Nataša, Blagojević, Slavica, Sarap, Nataša B., Maksimović, Jelena, Anić, Slobodan, Čupić, Željko, Kolar-Anić, Ljiljana, "Perturbations of the Dushman Reaction with Piroxicam: Experimental and Model Calculations" in Helvetica Chimica Acta, 97, no. 1 (2014):47-55,
https://doi.org/10.1002/hlca.201300109 . .

TY  - JOUR
AU  - Pejić, Nataša
AU  - Sarap, Nataša B.
AU  - Maksimović, Jelena
AU  - Anić, Slobodan
AU  - Kolar-Anić, Ljiljana
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1940
AB  - A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0A degrees C, [H2SO4](0) = 7.60x10(-2) mol L-1, [KIO3](0) = 5.90x10(-2) mol L-1, [H2O2](0) = 1.50x10(-1) mol L-1 and j (0) = 2.95x10(-2) min(-1)), the linear relationship between maximal potential shift Delta E (m) , and PX concentration was obtained in the concentration range 11.2-480.5 A mu g mL(-1) with a detection limit of 9.9 A mu g mL(-1). The method had a rather good sample throughput of 25 samples h(-1) with a precision RSD = 4.7% as well as recoveries RCV a parts per thousand currency sign 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated.
PB  - Versita, Warsaw
T2  - Central European Journal of Chemistry
T1  - Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system
VL  - 11
IS  - 2
SP  - 180
EP  - 188
DO  - 10.2478/s11532-012-0146-7
ER  - 

@article{
author = "Pejić, Nataša and Sarap, Nataša B. and Maksimović, Jelena and Anić, Slobodan and Kolar-Anić, Ljiljana",
year = "2013",
abstract = "A simple and reliable novel kinetic method for the determination of piroxicam (PX) was proposed and validated. For quantitative determination of PX, the Bray-Liebhafsky (BL) oscillatory reaction was used in a stable non-equilibrium stationary state close to the bifurcation point. Under the optimized reaction conditions (T = 55.0A degrees C, [H2SO4](0) = 7.60x10(-2) mol L-1, [KIO3](0) = 5.90x10(-2) mol L-1, [H2O2](0) = 1.50x10(-1) mol L-1 and j (0) = 2.95x10(-2) min(-1)), the linear relationship between maximal potential shift Delta E (m) , and PX concentration was obtained in the concentration range 11.2-480.5 A mu g mL(-1) with a detection limit of 9.9 A mu g mL(-1). The method had a rather good sample throughput of 25 samples h(-1) with a precision RSD = 4.7% as well as recoveries RCV a parts per thousand currency sign 104.4%. Applicability of the proposed method to the direct determination of piroxicam in different pharmaceutical formulations (tablets, ampoules and gel) was demonstrated.",
publisher = "Versita, Warsaw",
journal = "Central European Journal of Chemistry",
title = "Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system",
volume = "11",
number = "2",
pages = "180-188",
doi = "10.2478/s11532-012-0146-7"
}

Pejić, N., Sarap, N. B., Maksimović, J., Anić, S.,& Kolar-Anić, L.. (2013). Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system. in Central European Journal of Chemistry
Versita, Warsaw., 11(2), 180-188.
https://doi.org/10.2478/s11532-012-0146-7

Pejić N, Sarap NB, Maksimović J, Anić S, Kolar-Anić L. Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system. in Central European Journal of Chemistry. 2013;11(2):180-188.
doi:10.2478/s11532-012-0146-7 .

Pejić, Nataša, Sarap, Nataša B., Maksimović, Jelena, Anić, Slobodan, Kolar-Anić, Ljiljana, "Pulse perturbation technique for determination of piroxicam in pharmaceuticals using an oscillatory reaction system" in Central European Journal of Chemistry, 11, no. 2 (2013):180-188,
https://doi.org/10.2478/s11532-012-0146-7 . .