TY  - JOUR
AU  - Vukićević, Petar
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Mikić, Aleksandar
AU  - Bogavac-Stanojević, Nataša
AU  - Matković, Miloš
AU  - Putnik, Svetozar
AU  - Aleksić, Nemanja
AU  - Tutus, Vladimir
AU  - Karikas, Georg Albert
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3788
AB  - OBJECTIVE: Coronary artery bypass grafting (CABG) seems to present a powerful trigger of oxidative stress (OS) and acute inflammatory response. This study aimed to estimate the effects of off-pump coronary artery bypass (OPCAB) grafting on the OS that is commonly observed in patients undergoing operation under cardiopulmonary bypass (CPB). Additionally, we aimed to examine the relationship between and paraoxonase 1 (PON1) activity and the degree of stenosis, severity and complexity of the atherosclerotic lesions, estimated by SYNTAX score (SS). PATIENTS AND METHODS: Study group of 107 patients scheduled for CABG were divided into CPB and OPCAB group. Blood samples for OS markers measurement were collected at six-time intervals: before skin incision (t1), immediately after surgery (t2), 6h (t3), 24h (t4), 48h (t5) and 96h after cessation of the operation and surgical trauma (t6). SS was calculated. RESULTS: A significant decrease in lipid hydroperoxides (LOOH) and advanced oxidation protein products (AOPP) levels after both types of surgeries were observed, whereas PON1 reduction was observed higher in the CPB than in the OPCAB group. A significant inverse correlation between SS values and PON1 activity, preoperatively and during the early postoperative hours after surgery [in t2, t3 time intervals (p<0.05 for all)] was found. ROC analysis showed that for CPB patients, Model with all OS parameters showed excellent accuracy (AUC=0.957, p<0.001) for prediction postoperative complications. CONCLUSIONS: Decrease in PON1 activity during the early post-operative phases was related to higher SS. This relationship was more convincing in CPB, compared with OPCAB patients. Moreover, integrated models of OS status parameters have the capability to predict the development of postoperative complications.
PB  - Verduci Editore s.r.l
T2  - European Review for Medical and Pharmacological Sciences
T1  - Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery
VL  - 25
IS  - 3
SP  - 1511
EP  - 1521
DO  - 10.26355/eurrev_202102_24858
ER  - 

@article{
author = "Vukićević, Petar and Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Mikić, Aleksandar and Bogavac-Stanojević, Nataša and Matković, Miloš and Putnik, Svetozar and Aleksić, Nemanja and Tutus, Vladimir and Karikas, Georg Albert",
year = "2021",
abstract = "OBJECTIVE: Coronary artery bypass grafting (CABG) seems to present a powerful trigger of oxidative stress (OS) and acute inflammatory response. This study aimed to estimate the effects of off-pump coronary artery bypass (OPCAB) grafting on the OS that is commonly observed in patients undergoing operation under cardiopulmonary bypass (CPB). Additionally, we aimed to examine the relationship between and paraoxonase 1 (PON1) activity and the degree of stenosis, severity and complexity of the atherosclerotic lesions, estimated by SYNTAX score (SS). PATIENTS AND METHODS: Study group of 107 patients scheduled for CABG were divided into CPB and OPCAB group. Blood samples for OS markers measurement were collected at six-time intervals: before skin incision (t1), immediately after surgery (t2), 6h (t3), 24h (t4), 48h (t5) and 96h after cessation of the operation and surgical trauma (t6). SS was calculated. RESULTS: A significant decrease in lipid hydroperoxides (LOOH) and advanced oxidation protein products (AOPP) levels after both types of surgeries were observed, whereas PON1 reduction was observed higher in the CPB than in the OPCAB group. A significant inverse correlation between SS values and PON1 activity, preoperatively and during the early postoperative hours after surgery [in t2, t3 time intervals (p<0.05 for all)] was found. ROC analysis showed that for CPB patients, Model with all OS parameters showed excellent accuracy (AUC=0.957, p<0.001) for prediction postoperative complications. CONCLUSIONS: Decrease in PON1 activity during the early post-operative phases was related to higher SS. This relationship was more convincing in CPB, compared with OPCAB patients. Moreover, integrated models of OS status parameters have the capability to predict the development of postoperative complications.",
publisher = "Verduci Editore s.r.l",
journal = "European Review for Medical and Pharmacological Sciences",
title = "Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery",
volume = "25",
number = "3",
pages = "1511-1521",
doi = "10.26355/eurrev_202102_24858"
}

Vukićević, P., Klisić, A., Kotur-Stevuljević, J., Mikić, A., Bogavac-Stanojević, N., Matković, M., Putnik, S., Aleksić, N., Tutus, V.,& Karikas, G. A.. (2021). Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery. in European Review for Medical and Pharmacological Sciences
Verduci Editore s.r.l., 25(3), 1511-1521.
https://doi.org/10.26355/eurrev_202102_24858

Vukićević P, Klisić A, Kotur-Stevuljević J, Mikić A, Bogavac-Stanojević N, Matković M, Putnik S, Aleksić N, Tutus V, Karikas GA. Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery. in European Review for Medical and Pharmacological Sciences. 2021;25(3):1511-1521.
doi:10.26355/eurrev_202102_24858 .

Vukićević, Petar, Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Mikić, Aleksandar, Bogavac-Stanojević, Nataša, Matković, Miloš, Putnik, Svetozar, Aleksić, Nemanja, Tutus, Vladimir, Karikas, Georg Albert, "Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery" in European Review for Medical and Pharmacological Sciences, 25, no. 3 (2021):1511-1521,
https://doi.org/10.26355/eurrev_202102_24858 . .