TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Pejić, Ivana
AU  - Mijić, Smiljana
AU  - Pejčić, Aleksandra
AU  - Đurđević-Svraka, Anita
AU  - Svraka, Dragan
AU  - Knežević, Darija
AU  - Milivojac, Tatjana
AU  - Bogavac-Stanojević, Nataša
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5025
AB  - Background: The pandemic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) is a multi-system disease caused by a diffuse systemic process involving a complex interaction of the inflammatory, immunological and coagulative cascades. This study aims to identify the most effective biomarkers to predict poor outcome in intensive care unit (ICU) patients with severe COVID-19 disease. Methods: A single-centre retrospective observational study enrolled 69 deceased and 20 recovered patients treated in the ICU of the General Hospital Gradiska in the period from March 1, 2021. until April 1, 2022. We evaluated the leukocytes (WBC), lymphocytes (LYM), neutrophils (NEU), platelets (PLT), haemoglobin, neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). In addition, we evaluated the IL-6, ferritin, CRP, D-dimer, magnesium, bilirubin and lactate dehydrogenase. Results: Between deceased and recovered patients on admission to the ICU, there was a significant differencebetween the following parameters: WBC x10 9/L 11.50 (8.86–14.75) vs. 9.40 (5.90–11.90), p =0.026 ; NEU x10 9 /L 10.15 (7.81–12.74) vs. 8.60 (4.80–10.30) p=0.022 ; NLR 15.01 (10.60–24.33) vs. 9.45 (5.10– 14.90) p=0.02 ; SII 3712 (2240–6543) vs. 1949 (993–3720) p=0.003 . The magnesium level increased significantly over time in the patients who died, while the haemoglobin level and platelet count decreased. ROC analysis showed the following AUC values: WBC 0.774; NEU 0.781; NLR 0.786; SII 0.776; D-dimer 0.741, and bilirubin 0.713. Conclusion: In this retrospective study WBC, NEU, NLR, SII, D-dimer, and bilirubin determined at hospital admission had a high value in predicting death among patients with severe COVID-19.
AB  - Uvod: Pandemija teškog akutnog respiratornog sindroma koronavirusa 2 (SARS-CoV-2) je multisistemska bolest izazvana difuznim sistemskim procesom koji uključuje kompleksne interakcije inflamatornih, imunoloških i koagulacionih kaskadnih procesa. Cilj ove studije je da utvrdi najefikasnije biomarkere u proceni lošeg ishoda pacijenata u jedinici intenzivne nege (ICU) obolelih od teškog oblika bolesti COVID-19. Metode: Retrospektivna opservaciona studija je uključivala 69 preminulih i 20 preživelih pacijenata lečenih u ICU u Opštoj bolnici Gradiška u periodu od 01.03.2021. do 01.04.2022. godine. Procenjivane su vrednosti leukocita (WBC), limfocita (LYM), neutrofila (NEU), trombocita (PLT), hemoglobina, odnosa neutrofila i limfocita (NLR), odnosa trom bocita i limfocita (PLR), sistemskog inflama tornog indeksa (SII). Takođe, procenjivane su vrednosti inter leukina6, feritina, CRP, D-dimera, magnezijuma, bilirubina i aktivnost laktat dehidrogenaze. Rezultati: Prilikom prijema pacijenata u ICU postojala je značajna razlika u vrednostima sledećih parametara između preminulih i preživelih pacijenata: WBC x 109/L 11,50 (8,86-14,75) prema (vs.) 9,40 (5,90-11,90), p=0,026; NEU x109/L 10,15 (7,81-12,74) vs. 8,60 (4,80-10,30) p=0,022; NLR 15,01 (10,60-24,33) vs. 9,45 (5,10-14,90) p=0,02; SII 3712 (2240-6543) vs. 1949 (993-3720) p=0,003. Takođe, tokom vremena koncentracija magnezijuma je značajno rasla u grupi preminulih pacijenata, dok je koncentracija hemoglobina i broj trombocita opadao. ROC analiza je pokazala sledeće AUC vrednosti: WBC 0,774; NEU 0,781; NLR 0,786; SII 0,776; D-dimer 0,741 i bilirubin 0,713. Zaključak: U ovoj retrospektivnoj studiji WBC, NEU, NLR, SII, D-dimer i bilirubin, određeni pri prijemu u ICU, su imali visoku vrednost u predviđanju smrti između pacijenata s teškim COVID-19.

PB  - Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - The predictive role of biochemical markers on outcomes of severe Covid-19 patients admitted to intensive care unit
T1  - Uloga biohemijskih markera u predviđanju ishoda teško obolelih Covid-19 pacijenata primljenih na jedinicu intenzivnog lečenja
VL  - 42
IS  - 3
SP  - 513
EP  - 523
DO  - 10.5937/jomb0-40641
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Pejić, Ivana and Mijić, Smiljana and Pejčić, Aleksandra and Đurđević-Svraka, Anita and Svraka, Dragan and Knežević, Darija and Milivojac, Tatjana and Bogavac-Stanojević, Nataša",
year = "2023",
abstract = "Background: The pandemic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) is a multi-system disease caused by a diffuse systemic process involving a complex interaction of the inflammatory, immunological and coagulative cascades. This study aims to identify the most effective biomarkers to predict poor outcome in intensive care unit (ICU) patients with severe COVID-19 disease. Methods: A single-centre retrospective observational study enrolled 69 deceased and 20 recovered patients treated in the ICU of the General Hospital Gradiska in the period from March 1, 2021. until April 1, 2022. We evaluated the leukocytes (WBC), lymphocytes (LYM), neutrophils (NEU), platelets (PLT), haemoglobin, neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). In addition, we evaluated the IL-6, ferritin, CRP, D-dimer, magnesium, bilirubin and lactate dehydrogenase. Results: Between deceased and recovered patients on admission to the ICU, there was a significant differencebetween the following parameters: WBC x10 9/L 11.50 (8.86–14.75) vs. 9.40 (5.90–11.90), p =0.026 ; NEU x10 9 /L 10.15 (7.81–12.74) vs. 8.60 (4.80–10.30) p=0.022 ; NLR 15.01 (10.60–24.33) vs. 9.45 (5.10– 14.90) p=0.02 ; SII 3712 (2240–6543) vs. 1949 (993–3720) p=0.003 . The magnesium level increased significantly over time in the patients who died, while the haemoglobin level and platelet count decreased. ROC analysis showed the following AUC values: WBC 0.774; NEU 0.781; NLR 0.786; SII 0.776; D-dimer 0.741, and bilirubin 0.713. Conclusion: In this retrospective study WBC, NEU, NLR, SII, D-dimer, and bilirubin determined at hospital admission had a high value in predicting death among patients with severe COVID-19., Uvod: Pandemija teškog akutnog respiratornog sindroma koronavirusa 2 (SARS-CoV-2) je multisistemska bolest izazvana difuznim sistemskim procesom koji uključuje kompleksne interakcije inflamatornih, imunoloških i koagulacionih kaskadnih procesa. Cilj ove studije je da utvrdi najefikasnije biomarkere u proceni lošeg ishoda pacijenata u jedinici intenzivne nege (ICU) obolelih od teškog oblika bolesti COVID-19. Metode: Retrospektivna opservaciona studija je uključivala 69 preminulih i 20 preživelih pacijenata lečenih u ICU u Opštoj bolnici Gradiška u periodu od 01.03.2021. do 01.04.2022. godine. Procenjivane su vrednosti leukocita (WBC), limfocita (LYM), neutrofila (NEU), trombocita (PLT), hemoglobina, odnosa neutrofila i limfocita (NLR), odnosa trom bocita i limfocita (PLR), sistemskog inflama tornog indeksa (SII). Takođe, procenjivane su vrednosti inter leukina6, feritina, CRP, D-dimera, magnezijuma, bilirubina i aktivnost laktat dehidrogenaze. Rezultati: Prilikom prijema pacijenata u ICU postojala je značajna razlika u vrednostima sledećih parametara između preminulih i preživelih pacijenata: WBC x 109/L 11,50 (8,86-14,75) prema (vs.) 9,40 (5,90-11,90), p=0,026; NEU x109/L 10,15 (7,81-12,74) vs. 8,60 (4,80-10,30) p=0,022; NLR 15,01 (10,60-24,33) vs. 9,45 (5,10-14,90) p=0,02; SII 3712 (2240-6543) vs. 1949 (993-3720) p=0,003. Takođe, tokom vremena koncentracija magnezijuma je značajno rasla u grupi preminulih pacijenata, dok je koncentracija hemoglobina i broj trombocita opadao. ROC analiza je pokazala sledeće AUC vrednosti: WBC 0,774; NEU 0,781; NLR 0,786; SII 0,776; D-dimer 0,741 i bilirubin 0,713. Zaključak: U ovoj retrospektivnoj studiji WBC, NEU, NLR, SII, D-dimer i bilirubin, određeni pri prijemu u ICU, su imali visoku vrednost u predviđanju smrti između pacijenata s teškim COVID-19.
",
publisher = "Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "The predictive role of biochemical markers on outcomes of severe Covid-19 patients admitted to intensive care unit, Uloga biohemijskih markera u predviđanju ishoda teško obolelih Covid-19 pacijenata primljenih na jedinicu intenzivnog lečenja",
volume = "42",
number = "3",
pages = "513-523",
doi = "10.5937/jomb0-40641"
}

Mirjanić-Azarić, B., Pejić, I., Mijić, S., Pejčić, A., Đurđević-Svraka, A., Svraka, D., Knežević, D., Milivojac, T.,& Bogavac-Stanojević, N.. (2023). The predictive role of biochemical markers on outcomes of severe Covid-19 patients admitted to intensive care unit. in Journal of Medical Biochemistry
Society of Medical Biochemists of Serbia., 42(3), 513-523.
https://doi.org/10.5937/jomb0-40641

Mirjanić-Azarić B, Pejić I, Mijić S, Pejčić A, Đurđević-Svraka A, Svraka D, Knežević D, Milivojac T, Bogavac-Stanojević N. The predictive role of biochemical markers on outcomes of severe Covid-19 patients admitted to intensive care unit. in Journal of Medical Biochemistry. 2023;42(3):513-523.
doi:10.5937/jomb0-40641 .

Mirjanić-Azarić, Bosa, Pejić, Ivana, Mijić, Smiljana, Pejčić, Aleksandra, Đurđević-Svraka, Anita, Svraka, Dragan, Knežević, Darija, Milivojac, Tatjana, Bogavac-Stanojević, Nataša, "The predictive role of biochemical markers on outcomes of severe Covid-19 patients admitted to intensive care unit" in Journal of Medical Biochemistry, 42, no. 3 (2023):513-523,
https://doi.org/10.5937/jomb0-40641 . .

TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Milinković, Neda
AU  - Bogavac-Stanojević, Nataša
AU  - Avram, Sanja
AU  - Stojaković-Jelisavac, Tanja
AU  - Stojanović, Darja
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4173
AB  - Background: The aim of this study was to determine the reference intervals (RIs) for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and FT3/FT4 ratio using indirect methods. Methods: We analyzed 1256 results TSH, FT4 and FT3 collected from a laboratory information system between 2017 and 2021. All measurements were performed on a Siemens ADVIA Centaur XP analyzer using the chemiluminescent immunoassay. We calculated the values of the 2.5th and 97.5th percentiles as recommended by the IFCC (CLSI C28-A3). Results: The RIs derived for TSH, FT4, FT3 and FT3/FT4 ratio were 0.34–4.10 mIU/L, 11.3–20.6 pmol/L, 3.5–6.32 pmol/L and 0.21–0.47, respectively. We found a significant difference between calculated RIs for the TSH and FT4 and those recommended by the manufacturer. Also, FT3 values were significantly higher in the group younger than 30 years relative to the fourth decade (5.26 vs. 5.02, p=0.005), the fifth decade (5.26 vs. 4.94, p=0.001), the sixth decade (5.26 vs. 4.87, p<0.001), the seventh decade (5.26 vs. 4.79, p<0.001) and the group older than 70 years old (5.26 vs. 4.55, p<0.001). Likewise, we found for TSH values and FT3/FT4 ratio a significant difference (p <0.001) between different age groups. Conclusions: The establishing RIs for the population of the Republic of Srpska were significantly differed from the recommended RIs by the manufacturer for TSH and FT4. Our results encourage other laboratories to develop their own RIs for thyroid parameters by applying CLSI recommendations.
AB  - Uvod: Cilj ove studije bio je da se odrede referentni intervali (RI) tireotropnog hormona (TSH), slobodnog tiroksina (FT4), slobodnog trijodotironina (FT3) i odnosa FT3/FT4 indirektnom metodom procene referentnih intervala. Metode: Analizirali smo 1256 dobijenih vrednosti TSH, FT4 i FT3 u periodu između 2017. i 2021. godine. Rezultate smo uzeli iz laboratorijskog informacionog sistema. Sva merenja su izvedena na Siemens ADVIA Centaur XP analizatoru pomo}u hemiluminiscentnih imunohemijskih testova. Izračunali smo vrednosti 2,5-og i 97,5-og percentila prema preporuci IFCC-a (CLSI C28-A3). Rezultati: Procenjeni RI za TSH, FT4, FT3 i odnos FT3/FT4 bili su 0,34-4,10 mIU/L; 11,3-20,6 pmol/L; 3,5-6,32 pmol/L i 0,21-0,47. Utvrdili smo značajnu razliku između izračunatih RI za TSH i FT4 i onih koje preporučuje proizvođač. Takođe, vrednosti FT3 bile su značajno ve}e u grupi mlađoj od 30 godina u odnosu na četvrtu deceniju (5,26 vs. 5,02; p = 0,005), petu deceniju (5,26 vs. 4,94; p = 0,001), šestu deceniju (5,26 vs. 4,87; p<0,001), sedmu deceniju (5,26 vs. 4,79; p<0,001) i grupu stariju od 70 godina (5,26 vs. 4,55; p<0,001). Isto tako, za vrednosti TSH i odnos FT3/FT4 pronašli smo značajnu razliku (p <0,001) između različitih dobnih grupa. Zaključak: Procenjene vrednosti referentnih intervala za TSH i FT4 za stanovništvo Republike Srpske značajno su se razlikovale od preporučenih RI od strane proizvođača. Naši rezultati podstiču druge laboratorije da izrade sopstvene RI za parametre štitne žlezde primenom CLSI preporuka.
PB  - Society of Medical Biochemists of Serbia
T2  - Journal of Medical Biochemistry
T1  - Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer
T1  - Indirektna procjena referentnih intervala za parametre štitne žlijezde upotrebom advia centaur XP analizatora
VL  - 41
IS  - 2
SP  - 238
EP  - 245
DO  - 10.5937/jomb0-33543
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Milinković, Neda and Bogavac-Stanojević, Nataša and Avram, Sanja and Stojaković-Jelisavac, Tanja and Stojanović, Darja",
year = "2022",
abstract = "Background: The aim of this study was to determine the reference intervals (RIs) for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) and FT3/FT4 ratio using indirect methods. Methods: We analyzed 1256 results TSH, FT4 and FT3 collected from a laboratory information system between 2017 and 2021. All measurements were performed on a Siemens ADVIA Centaur XP analyzer using the chemiluminescent immunoassay. We calculated the values of the 2.5th and 97.5th percentiles as recommended by the IFCC (CLSI C28-A3). Results: The RIs derived for TSH, FT4, FT3 and FT3/FT4 ratio were 0.34–4.10 mIU/L, 11.3–20.6 pmol/L, 3.5–6.32 pmol/L and 0.21–0.47, respectively. We found a significant difference between calculated RIs for the TSH and FT4 and those recommended by the manufacturer. Also, FT3 values were significantly higher in the group younger than 30 years relative to the fourth decade (5.26 vs. 5.02, p=0.005), the fifth decade (5.26 vs. 4.94, p=0.001), the sixth decade (5.26 vs. 4.87, p<0.001), the seventh decade (5.26 vs. 4.79, p<0.001) and the group older than 70 years old (5.26 vs. 4.55, p<0.001). Likewise, we found for TSH values and FT3/FT4 ratio a significant difference (p <0.001) between different age groups. Conclusions: The establishing RIs for the population of the Republic of Srpska were significantly differed from the recommended RIs by the manufacturer for TSH and FT4. Our results encourage other laboratories to develop their own RIs for thyroid parameters by applying CLSI recommendations., Uvod: Cilj ove studije bio je da se odrede referentni intervali (RI) tireotropnog hormona (TSH), slobodnog tiroksina (FT4), slobodnog trijodotironina (FT3) i odnosa FT3/FT4 indirektnom metodom procene referentnih intervala. Metode: Analizirali smo 1256 dobijenih vrednosti TSH, FT4 i FT3 u periodu između 2017. i 2021. godine. Rezultate smo uzeli iz laboratorijskog informacionog sistema. Sva merenja su izvedena na Siemens ADVIA Centaur XP analizatoru pomo}u hemiluminiscentnih imunohemijskih testova. Izračunali smo vrednosti 2,5-og i 97,5-og percentila prema preporuci IFCC-a (CLSI C28-A3). Rezultati: Procenjeni RI za TSH, FT4, FT3 i odnos FT3/FT4 bili su 0,34-4,10 mIU/L; 11,3-20,6 pmol/L; 3,5-6,32 pmol/L i 0,21-0,47. Utvrdili smo značajnu razliku između izračunatih RI za TSH i FT4 i onih koje preporučuje proizvođač. Takođe, vrednosti FT3 bile su značajno ve}e u grupi mlađoj od 30 godina u odnosu na četvrtu deceniju (5,26 vs. 5,02; p = 0,005), petu deceniju (5,26 vs. 4,94; p = 0,001), šestu deceniju (5,26 vs. 4,87; p<0,001), sedmu deceniju (5,26 vs. 4,79; p<0,001) i grupu stariju od 70 godina (5,26 vs. 4,55; p<0,001). Isto tako, za vrednosti TSH i odnos FT3/FT4 pronašli smo značajnu razliku (p <0,001) između različitih dobnih grupa. Zaključak: Procenjene vrednosti referentnih intervala za TSH i FT4 za stanovništvo Republike Srpske značajno su se razlikovale od preporučenih RI od strane proizvođača. Naši rezultati podstiču druge laboratorije da izrade sopstvene RI za parametre štitne žlezde primenom CLSI preporuka.",
publisher = "Society of Medical Biochemists of Serbia",
journal = "Journal of Medical Biochemistry",
title = "Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer, Indirektna procjena referentnih intervala za parametre štitne žlijezde upotrebom advia centaur XP analizatora",
volume = "41",
number = "2",
pages = "238-245",
doi = "10.5937/jomb0-33543"
}

Mirjanić-Azarić, B., Milinković, N., Bogavac-Stanojević, N., Avram, S., Stojaković-Jelisavac, T.,& Stojanović, D.. (2022). Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer. in Journal of Medical Biochemistry
Society of Medical Biochemists of Serbia., 41(2), 238-245.
https://doi.org/10.5937/jomb0-33543

Mirjanić-Azarić B, Milinković N, Bogavac-Stanojević N, Avram S, Stojaković-Jelisavac T, Stojanović D. Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer. in Journal of Medical Biochemistry. 2022;41(2):238-245.
doi:10.5937/jomb0-33543 .

Mirjanić-Azarić, Bosa, Milinković, Neda, Bogavac-Stanojević, Nataša, Avram, Sanja, Stojaković-Jelisavac, Tanja, Stojanović, Darja, "Indirect estimation of reference intervals for thyroid parameters using advia centaur XP analyzer" in Journal of Medical Biochemistry, 41, no. 2 (2022):238-245,
https://doi.org/10.5937/jomb0-33543 . .

TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Vasić, Novak
AU  - Cerne, Darko
AU  - Kos, Janko
AU  - Bogavac-Stanojević, Nataša
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3338
AB  - Background: Cathepsin S (CTSS) is a cysteine protease involved in atherogenesis. We compared the plasma CTSS as well as other biomarkers of atherosclerosis in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD), aiming to identify the underlying pathogenic mechanisms of the disease development. Also, we hypothesised that the level of plasma CTSS simultaneously increases with a decrease of plasma high-density lipoprotein cholesterol (HDL-C) values. Methods: 33 patients with AAA and 34 patients with AOD were included in this study. Results: There was no difference in the level of plasma CTSS between the two analysed groups (p=0.833). In the patients with AAA, the plasma CTSS was correlated with HDL-C (r = -0.377, p = 0.034) and total bilirubin (r = 0.500, p = 0.003) while, unexpectedly, it was not correlated with cystatin C (Cys C) (r = 0.083, p = 0.652). In the patients with AOD, the plasma CTSS correlated with triglycerides (r = 0.597, p  lt  0.001), only. When the patients were divided according to HDL-C (with HDL-C  lt = 0.90 and HDL-C >0.90 mmol/L), the plasma CTSS values differed among these groups (31.27 vs.25.61 mu g/L, respectively, p lt 0.001). Conclusions: These results provide the first evidence that CTSS negatively correlated with HDL-C and bilirubin in patients with AAA. It is possible that differences in the association of the CTSS and other markers of atherosclerosis can determine whether atherosclerotic aorta will develop dilatation or stenosis.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms
VL  - 38
IS  - 3
SP  - 268
EP  - 275
DO  - 10.2478/jomb-2018-0039
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Vasić, Novak and Cerne, Darko and Kos, Janko and Bogavac-Stanojević, Nataša",
year = "2019",
abstract = "Background: Cathepsin S (CTSS) is a cysteine protease involved in atherogenesis. We compared the plasma CTSS as well as other biomarkers of atherosclerosis in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD), aiming to identify the underlying pathogenic mechanisms of the disease development. Also, we hypothesised that the level of plasma CTSS simultaneously increases with a decrease of plasma high-density lipoprotein cholesterol (HDL-C) values. Methods: 33 patients with AAA and 34 patients with AOD were included in this study. Results: There was no difference in the level of plasma CTSS between the two analysed groups (p=0.833). In the patients with AAA, the plasma CTSS was correlated with HDL-C (r = -0.377, p = 0.034) and total bilirubin (r = 0.500, p = 0.003) while, unexpectedly, it was not correlated with cystatin C (Cys C) (r = 0.083, p = 0.652). In the patients with AOD, the plasma CTSS correlated with triglycerides (r = 0.597, p  lt  0.001), only. When the patients were divided according to HDL-C (with HDL-C  lt = 0.90 and HDL-C >0.90 mmol/L), the plasma CTSS values differed among these groups (31.27 vs.25.61 mu g/L, respectively, p lt 0.001). Conclusions: These results provide the first evidence that CTSS negatively correlated with HDL-C and bilirubin in patients with AAA. It is possible that differences in the association of the CTSS and other markers of atherosclerosis can determine whether atherosclerotic aorta will develop dilatation or stenosis.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms",
volume = "38",
number = "3",
pages = "268-275",
doi = "10.2478/jomb-2018-0039"
}

Mirjanić-Azarić, B., Vasić, N., Cerne, D., Kos, J.,& Bogavac-Stanojević, N.. (2019). Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(3), 268-275.
https://doi.org/10.2478/jomb-2018-0039

Mirjanić-Azarić B, Vasić N, Cerne D, Kos J, Bogavac-Stanojević N. Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms. in Journal of Medical Biochemistry. 2019;38(3):268-275.
doi:10.2478/jomb-2018-0039 .

Mirjanić-Azarić, Bosa, Vasić, Novak, Cerne, Darko, Kos, Janko, Bogavac-Stanojević, Nataša, "Plasma cathepsin S is associated with high-density lipoprotein cholesterol and bilirubin in patients with abdominal aortic aneurysms" in Journal of Medical Biochemistry, 38, no. 3 (2019):268-275,
https://doi.org/10.2478/jomb-2018-0039 . .

TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Avram, Sanja
AU  - Stojaković-Jelisavac, Tanja
AU  - Stojanović, Darja
AU  - Petković, Mira
AU  - Bogavac-Stanojević, Nataša
AU  - Ignjatović, Svetlana
AU  - Stojanov, Marina
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3008
AB  - Background: The aim of this study was to determine the reference values for thyrotropin (TSH), thyroid hormones (total and free thyroxine, T4 and fT4; total and free triiodothyronine, T3 and fT3), thyroglobulin (Tg) and thyroid antibodies (thyroid peroxidase, TPOAb and thyroglobulin antibody, TgAb) in the population of the Republic of Srpska. Methods: A total of 250 euthyroid subjects were enrolled in this study. A direct method for choosing reference subjects was used to establish reference intervals. The hormones and thyroid antibodies were measured by an electrochemiluminescence immunoassay method (ECLIA, Roche Diagnostics, Mannheim, Germany). We calculated the re f erence intervals by MedCalc, version 12.1.4.0 (MedCalc software, Belgium) as recommended by the IFCC (CLSI C28-A3). Results: Using guidelines recommended by the National Academy of Clinical Biochemistry (NACB) and based on standard statistical approaches, the reference intervals derived for TSH, fT4, T4, fT3, T3 were 0.75-5.32 mIU/L, 12.29-20.03 pmol/L, 73.49-126,30 nmol/L, 4.11-6.32 pmol/L, 1.15-2.32 nmol/L and for Tg, TPOAb, TgAb were 3.63-26.00 mu g/L,  lt  18.02 mIU/L,  lt  98.00 mIU/L, respe ctively. We found a significant difference (p lt  0.05) in TSH and fT3 values between different age groups as well as in T4, fT4 and fT3 values between ge nder groups. Conclusions: The established reference values for the population of the Republic of Srpska were significantly different from the values recommended by the manufacturer of reagents (Roche Diagnostics). Our results showed that a laboratory needs to establish its own reference values in order to set up a proper diagnosis, as well as to treat patients successfully.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska
VL  - 36
IS  - 2
SP  - 137
EP  - 144
DO  - 10.1515/jomb-2017-0008
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Avram, Sanja and Stojaković-Jelisavac, Tanja and Stojanović, Darja and Petković, Mira and Bogavac-Stanojević, Nataša and Ignjatović, Svetlana and Stojanov, Marina",
year = "2017",
abstract = "Background: The aim of this study was to determine the reference values for thyrotropin (TSH), thyroid hormones (total and free thyroxine, T4 and fT4; total and free triiodothyronine, T3 and fT3), thyroglobulin (Tg) and thyroid antibodies (thyroid peroxidase, TPOAb and thyroglobulin antibody, TgAb) in the population of the Republic of Srpska. Methods: A total of 250 euthyroid subjects were enrolled in this study. A direct method for choosing reference subjects was used to establish reference intervals. The hormones and thyroid antibodies were measured by an electrochemiluminescence immunoassay method (ECLIA, Roche Diagnostics, Mannheim, Germany). We calculated the re f erence intervals by MedCalc, version 12.1.4.0 (MedCalc software, Belgium) as recommended by the IFCC (CLSI C28-A3). Results: Using guidelines recommended by the National Academy of Clinical Biochemistry (NACB) and based on standard statistical approaches, the reference intervals derived for TSH, fT4, T4, fT3, T3 were 0.75-5.32 mIU/L, 12.29-20.03 pmol/L, 73.49-126,30 nmol/L, 4.11-6.32 pmol/L, 1.15-2.32 nmol/L and for Tg, TPOAb, TgAb were 3.63-26.00 mu g/L,  lt  18.02 mIU/L,  lt  98.00 mIU/L, respe ctively. We found a significant difference (p lt  0.05) in TSH and fT3 values between different age groups as well as in T4, fT4 and fT3 values between ge nder groups. Conclusions: The established reference values for the population of the Republic of Srpska were significantly different from the values recommended by the manufacturer of reagents (Roche Diagnostics). Our results showed that a laboratory needs to establish its own reference values in order to set up a proper diagnosis, as well as to treat patients successfully.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska",
volume = "36",
number = "2",
pages = "137-144",
doi = "10.1515/jomb-2017-0008"
}

Mirjanić-Azarić, B., Avram, S., Stojaković-Jelisavac, T., Stojanović, D., Petković, M., Bogavac-Stanojević, N., Ignjatović, S.,& Stojanov, M.. (2017). Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 36(2), 137-144.
https://doi.org/10.1515/jomb-2017-0008

Mirjanić-Azarić B, Avram S, Stojaković-Jelisavac T, Stojanović D, Petković M, Bogavac-Stanojević N, Ignjatović S, Stojanov M. Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska. in Journal of Medical Biochemistry. 2017;36(2):137-144.
doi:10.1515/jomb-2017-0008 .

Mirjanić-Azarić, Bosa, Avram, Sanja, Stojaković-Jelisavac, Tanja, Stojanović, Darja, Petković, Mira, Bogavac-Stanojević, Nataša, Ignjatović, Svetlana, Stojanov, Marina, "Direct Estimation of Reference Intervals for Thyroid Parameters in the Republic of Srpska" in Journal of Medical Biochemistry, 36, no. 2 (2017):137-144,
https://doi.org/10.1515/jomb-2017-0008 . .

TY  - CONF
AU  - Mirjanić-Azarić, Bosa
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Juergens, Guenter
AU  - Cerne, Darko
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2829
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Correlations of Cathepsin S with lipoprotein subclasses levels and lipid parameters in patients with stable angina
VL  - 263
SP  - e213
EP  - e214
DO  - 10.1016/j.atherosclerosis.2017.06.694
ER  - 

@conference{
author = "Mirjanić-Azarić, Bosa and Zeljković, Aleksandra and Vekić, Jelena and Juergens, Guenter and Cerne, Darko",
year = "2017",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Correlations of Cathepsin S with lipoprotein subclasses levels and lipid parameters in patients with stable angina",
volume = "263",
pages = "e213-e214",
doi = "10.1016/j.atherosclerosis.2017.06.694"
}

Mirjanić-Azarić, B., Zeljković, A., Vekić, J., Juergens, G.,& Cerne, D.. (2017). Correlations of Cathepsin S with lipoprotein subclasses levels and lipid parameters in patients with stable angina. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 263, e213-e214.
https://doi.org/10.1016/j.atherosclerosis.2017.06.694

Mirjanić-Azarić B, Zeljković A, Vekić J, Juergens G, Cerne D. Correlations of Cathepsin S with lipoprotein subclasses levels and lipid parameters in patients with stable angina. in Atherosclerosis. 2017;263:e213-e214.
doi:10.1016/j.atherosclerosis.2017.06.694 .

Mirjanić-Azarić, Bosa, Zeljković, Aleksandra, Vekić, Jelena, Juergens, Guenter, Cerne, Darko, "Correlations of Cathepsin S with lipoprotein subclasses levels and lipid parameters in patients with stable angina" in Atherosclerosis, 263 (2017):e213-e214,
https://doi.org/10.1016/j.atherosclerosis.2017.06.694 . .

TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Jelić-Ivanović, Zorana
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Juergens, Guenther
AU  - Milivojac, Tatjana
AU  - Avram, Sanja
AU  - Ćorić, Jozo
AU  - Marc, Janja
AU  - Černe, Darko
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2432
AB  - Background: High-density lipoproteins (HDL) have atheroprotective biological properties: antioxidative, anti-apoptotic, anti-inflammatory, and they have the efflux capacity of cellular cholesterol. Plasma mRNA analysis can be used to investigate statin pleiotropy in vivo as a new analytical tool for non-invasive assessment of gene expression in vascular beds. The aim of this study was to assess the pleiotropic effects of atorvastatin in stable angina patients with highrisk values (group A) as compared with patients who had borderline and desirable HDL-cholesterol (HDL-C) values (group B). Methods: The atorvastatin therapy (20 mg/day) was given to forty-three patients with stable angina for 10 weeks. We investigated three statin pleiotropy-targeted genes: intercellular adhesion molecule-1, chemokine (C-C motif) ligand 2 and cathepsin S and assessed by gel electrophoresis gradient the effects of atorvastatin on HDL size and subclasses. Results: In group A, after therapy, HDL-C concentration was significantly increased but not in group B. Atorvastatin lowered plasma chemokine (C-C motif) ligand 2 and intercellular adhesion molecule-1 mRNA levels in both groups, but did not change the plasma cathepsin S mRNA levels. In group A only, baseline total bilirubin showed negative cor relations with the genes of cathepsin S (r=-0.506; p = 0.023) and significantly increased after therapy. Conclusions: HDL-C and bilirubin can be promising therapeutic targets in the treatment of cardiovascular diseases. Analysis of cell-free mRNA in plasma might become a useful tool for estimating statin pleiotropy.
AB  - Uvod: Lipoproteini velike gustine (HDL) imaju ateroprotektivne biološke osobine: antioksidativne, antiapoptotičke, antiinflamatorne kao i kapacitet da izvlače holesterol iz ćelija. Analiza plazmatske mRNA može da se koristi za ispitivanje plejotropnih efekata statina in vivo kao novo analitičko sredstvo za neinvazivnu procenu ekspresije gena u zidu krvnog suda. Cilj ove studije je bio da se procene plejotropni efekti atorvastatina kod pacijenata sa stabilnom anginom sa visokorizičnim vrednostima (grupa A) u odnosu na pacijente sa graničnim i poželjnim vrednostima HDL holesterola (HDLC) (grupa B). Metode: Četrdeset tri pacijenta sa stabilnom anginom su primala terapiju atorvastatinom (20 mg/dan) 10 nedelja. Mi smo ispitivali tri gena značajna za plejotropno delovanje statina: intracelularni adhezioni molekul-1, hemokin (C-C motiv) ligand 2 i katepsin S i procenjivali smo efekte atorvastatina na veličinu i raspodelu HDL subfrakcija pomoću elektroforeze na poliakrilamidnom gradijent gelu. Rezultati: U grupi A, posle terapije, HDL-C koncentracija se značajno povećala, ali ne i u grupi B. Atorvastatin je snizio plazmatski nivo hemokin (C-C motiv) liganda 2 i intracelularnog adhezionog molekula-1 mRNA u obe grupe, ali nije promenio plazmatski nivo gena za katepsin S. Samo u grupi A, ukupni bilirubin je pokazao negativnu korelaciju sa genom za katepsin S (r = -0,506; p = 0,023) pre započinjanja terapije i značajni porast nakon terapije atorvastatinom. Zaključak: HDL-C i bilirubin mogu biti obećavajući terapijski ciljevi u lečenju kardiovaskularnih bolesti. Analiza slobodne mRNA (eng. cell-free mRNA) u plazmi može postati korisno sredstvo za procenu plejotropnog delovanja statina.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - The Pleiotropic Effects of Atorvastatin on Stable Angina Patients: Evidence by Analysis of High-Density Lipoprotein Size and Subclasses, and Plasma mRNA
T1  - Plejotropni efekti atorvastatina kod pacijenata sa stabilnom anginom - dokazi dobijeni analizom veličine i raspodele subfrakcija lipoproteina velike gustine i plazmatske mRNA
VL  - 34
IS  - 3
SP  - 314
EP  - 322
DO  - 10.2478/jomb-2014-0058
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Jelić-Ivanović, Zorana and Zeljković, Aleksandra and Vekić, Jelena and Juergens, Guenther and Milivojac, Tatjana and Avram, Sanja and Ćorić, Jozo and Marc, Janja and Černe, Darko",
year = "2015",
abstract = "Background: High-density lipoproteins (HDL) have atheroprotective biological properties: antioxidative, anti-apoptotic, anti-inflammatory, and they have the efflux capacity of cellular cholesterol. Plasma mRNA analysis can be used to investigate statin pleiotropy in vivo as a new analytical tool for non-invasive assessment of gene expression in vascular beds. The aim of this study was to assess the pleiotropic effects of atorvastatin in stable angina patients with highrisk values (group A) as compared with patients who had borderline and desirable HDL-cholesterol (HDL-C) values (group B). Methods: The atorvastatin therapy (20 mg/day) was given to forty-three patients with stable angina for 10 weeks. We investigated three statin pleiotropy-targeted genes: intercellular adhesion molecule-1, chemokine (C-C motif) ligand 2 and cathepsin S and assessed by gel electrophoresis gradient the effects of atorvastatin on HDL size and subclasses. Results: In group A, after therapy, HDL-C concentration was significantly increased but not in group B. Atorvastatin lowered plasma chemokine (C-C motif) ligand 2 and intercellular adhesion molecule-1 mRNA levels in both groups, but did not change the plasma cathepsin S mRNA levels. In group A only, baseline total bilirubin showed negative cor relations with the genes of cathepsin S (r=-0.506; p = 0.023) and significantly increased after therapy. Conclusions: HDL-C and bilirubin can be promising therapeutic targets in the treatment of cardiovascular diseases. Analysis of cell-free mRNA in plasma might become a useful tool for estimating statin pleiotropy., Uvod: Lipoproteini velike gustine (HDL) imaju ateroprotektivne biološke osobine: antioksidativne, antiapoptotičke, antiinflamatorne kao i kapacitet da izvlače holesterol iz ćelija. Analiza plazmatske mRNA može da se koristi za ispitivanje plejotropnih efekata statina in vivo kao novo analitičko sredstvo za neinvazivnu procenu ekspresije gena u zidu krvnog suda. Cilj ove studije je bio da se procene plejotropni efekti atorvastatina kod pacijenata sa stabilnom anginom sa visokorizičnim vrednostima (grupa A) u odnosu na pacijente sa graničnim i poželjnim vrednostima HDL holesterola (HDLC) (grupa B). Metode: Četrdeset tri pacijenta sa stabilnom anginom su primala terapiju atorvastatinom (20 mg/dan) 10 nedelja. Mi smo ispitivali tri gena značajna za plejotropno delovanje statina: intracelularni adhezioni molekul-1, hemokin (C-C motiv) ligand 2 i katepsin S i procenjivali smo efekte atorvastatina na veličinu i raspodelu HDL subfrakcija pomoću elektroforeze na poliakrilamidnom gradijent gelu. Rezultati: U grupi A, posle terapije, HDL-C koncentracija se značajno povećala, ali ne i u grupi B. Atorvastatin je snizio plazmatski nivo hemokin (C-C motiv) liganda 2 i intracelularnog adhezionog molekula-1 mRNA u obe grupe, ali nije promenio plazmatski nivo gena za katepsin S. Samo u grupi A, ukupni bilirubin je pokazao negativnu korelaciju sa genom za katepsin S (r = -0,506; p = 0,023) pre započinjanja terapije i značajni porast nakon terapije atorvastatinom. Zaključak: HDL-C i bilirubin mogu biti obećavajući terapijski ciljevi u lečenju kardiovaskularnih bolesti. Analiza slobodne mRNA (eng. cell-free mRNA) u plazmi može postati korisno sredstvo za procenu plejotropnog delovanja statina.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "The Pleiotropic Effects of Atorvastatin on Stable Angina Patients: Evidence by Analysis of High-Density Lipoprotein Size and Subclasses, and Plasma mRNA, Plejotropni efekti atorvastatina kod pacijenata sa stabilnom anginom - dokazi dobijeni analizom veličine i raspodele subfrakcija lipoproteina velike gustine i plazmatske mRNA",
volume = "34",
number = "3",
pages = "314-322",
doi = "10.2478/jomb-2014-0058"
}

Mirjanić-Azarić, B., Jelić-Ivanović, Z., Zeljković, A., Vekić, J., Juergens, G., Milivojac, T., Avram, S., Ćorić, J., Marc, J.,& Černe, D.. (2015). The Pleiotropic Effects of Atorvastatin on Stable Angina Patients: Evidence by Analysis of High-Density Lipoprotein Size and Subclasses, and Plasma mRNA. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(3), 314-322.
https://doi.org/10.2478/jomb-2014-0058

Mirjanić-Azarić B, Jelić-Ivanović Z, Zeljković A, Vekić J, Juergens G, Milivojac T, Avram S, Ćorić J, Marc J, Černe D. The Pleiotropic Effects of Atorvastatin on Stable Angina Patients: Evidence by Analysis of High-Density Lipoprotein Size and Subclasses, and Plasma mRNA. in Journal of Medical Biochemistry. 2015;34(3):314-322.
doi:10.2478/jomb-2014-0058 .

Mirjanić-Azarić, Bosa, Jelić-Ivanović, Zorana, Zeljković, Aleksandra, Vekić, Jelena, Juergens, Guenther, Milivojac, Tatjana, Avram, Sanja, Ćorić, Jozo, Marc, Janja, Černe, Darko, "The Pleiotropic Effects of Atorvastatin on Stable Angina Patients: Evidence by Analysis of High-Density Lipoprotein Size and Subclasses, and Plasma mRNA" in Journal of Medical Biochemistry, 34, no. 3 (2015):314-322,
https://doi.org/10.2478/jomb-2014-0058 . .

TY  - JOUR
AU  - Mirjanić-Azarić, Bosa
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Đerić, Mirjana
AU  - Milivojac, Tatjana
AU  - Fonović, Ursa Pecar
AU  - Marc, Janja
AU  - Kos, Janko
AU  - Cerne, Darko
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2069
AB  - Aim: We hypothesized that, in stable angina patients, atorvastatin therapy lowers the cathepsin S (CTSS) concentrations, as assessed non-invasively according to a plasma analysis. In addition, the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in the plasma were analysed to establish the association between CTSS and lipoprotein metabolism and determine whether this association is atorvastatin-sensitive. Methods: A total of 43 patients with stable angina received atorvastatin therapy (20 mg/day, 10 weeks). The plasma CTSS mRNA levels, CTSS protein concentrations and CTSS activity, as well as LDL and HDL size and subclasses, were analysed before and after treatment. Results: Atorvastatin treatment did not change the plasma CTSS mRNA levels, although it lowered the plasma CTSS concentrations and activity. An increased plasma CTSS concentration and activity were found to be associated with a more atherogenic LDL subclass profile (a decreased dominant LDL size and increased percentage of small, dense LDL particles). The atorvastatin-induced CTSS-lowering effect was concomitant with an improvement in the LDL subclass profile, and the changes were found to be interrelated. Concomitant, interrelated changes in the CTSS levels and LDL subclass profiles were found in the LDL phenotype B patients only (a dominant LDL diameter of  lt = 25.5 nm at the start of the study). In this subgroup, lowering of the plasma CTSS mRNA level also correlated with lowering of the proportion of small, dense LDL particles. Conclusions: Atorvastatin-induced CTSS-lowering and LDL subclass profile improvements in the plasma of LDL phenotype B patients with stable angina are concomitant and interrelated.
PB  - Japan Atherosclerosis Soc, Tokyo
T2  - Journal of Atherosclerosis and Thrombosis
T1  - Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients
VL  - 21
IS  - 8
SP  - 868
EP  - 877
DO  - 10.5551/jat.21410
ER  - 

@article{
author = "Mirjanić-Azarić, Bosa and Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Đerić, Mirjana and Milivojac, Tatjana and Fonović, Ursa Pecar and Marc, Janja and Kos, Janko and Cerne, Darko",
year = "2014",
abstract = "Aim: We hypothesized that, in stable angina patients, atorvastatin therapy lowers the cathepsin S (CTSS) concentrations, as assessed non-invasively according to a plasma analysis. In addition, the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in the plasma were analysed to establish the association between CTSS and lipoprotein metabolism and determine whether this association is atorvastatin-sensitive. Methods: A total of 43 patients with stable angina received atorvastatin therapy (20 mg/day, 10 weeks). The plasma CTSS mRNA levels, CTSS protein concentrations and CTSS activity, as well as LDL and HDL size and subclasses, were analysed before and after treatment. Results: Atorvastatin treatment did not change the plasma CTSS mRNA levels, although it lowered the plasma CTSS concentrations and activity. An increased plasma CTSS concentration and activity were found to be associated with a more atherogenic LDL subclass profile (a decreased dominant LDL size and increased percentage of small, dense LDL particles). The atorvastatin-induced CTSS-lowering effect was concomitant with an improvement in the LDL subclass profile, and the changes were found to be interrelated. Concomitant, interrelated changes in the CTSS levels and LDL subclass profiles were found in the LDL phenotype B patients only (a dominant LDL diameter of  lt = 25.5 nm at the start of the study). In this subgroup, lowering of the plasma CTSS mRNA level also correlated with lowering of the proportion of small, dense LDL particles. Conclusions: Atorvastatin-induced CTSS-lowering and LDL subclass profile improvements in the plasma of LDL phenotype B patients with stable angina are concomitant and interrelated.",
publisher = "Japan Atherosclerosis Soc, Tokyo",
journal = "Journal of Atherosclerosis and Thrombosis",
title = "Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients",
volume = "21",
number = "8",
pages = "868-877",
doi = "10.5551/jat.21410"
}

Mirjanić-Azarić, B., Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Đerić, M., Milivojac, T., Fonović, U. P., Marc, J., Kos, J.,& Cerne, D.. (2014). Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients. in Journal of Atherosclerosis and Thrombosis
Japan Atherosclerosis Soc, Tokyo., 21(8), 868-877.
https://doi.org/10.5551/jat.21410

Mirjanić-Azarić B, Vekić J, Zeljković A, Jelić-Ivanović Z, Đerić M, Milivojac T, Fonović UP, Marc J, Kos J, Cerne D. Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients. in Journal of Atherosclerosis and Thrombosis. 2014;21(8):868-877.
doi:10.5551/jat.21410 .

Mirjanić-Azarić, Bosa, Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Đerić, Mirjana, Milivojac, Tatjana, Fonović, Ursa Pecar, Marc, Janja, Kos, Janko, Cerne, Darko, "Interrelated Cathepsin S-Lowering and LDL Subclass Profile Improvements Induced by Atorvastatin in the Plasma of Stable Angina Patients" in Journal of Atherosclerosis and Thrombosis, 21, no. 8 (2014):868-877,
https://doi.org/10.5551/jat.21410 . .