TY  - JOUR
AU  - Vuković-Dejanović, Vesna
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Bogavac-Stanojević, Nataša
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4245
AB  - Statins have been shown to decrease inflammatory markers, especially high sensitivity C reactive protein (hsCRP), in a dose-dependent manner. Pentraxin-3 (PTX3) is another important inflammatory biomarker from the pentraxin family that provides useful prognostic information and facilitates diagnostics of cardiovascular diseases. This study investigated the effect of statin therapy on PTX3 and hsCRP concentrations and whether statins acted synergistically with PTX3 and hsCRP concentrations in lowering LDL-C. The study group consisted of 90 patients undergoing coronary angiography. The results showed that statins reduced PTX3 concentrations (p=0.031). PTX3 and hsCRP levels were significantly different between subclinical and severe stenosis groups (p=0.011 and p=0.009, respectively). Statin therapy was significantly associated with lower PTX3 and LDL-C levels in multiple logistic analyses. The probability that statin therapy would achieve target LDL-C values was highest in patients with low PTX3 values (OR=3.683, p=0.040), while multiplicative interaction was 23.3. The effect of statins on PTX3 reduction was higher than on hsCRP. It can be suggested that statin therapy was more successful in patients with low PTX3 values.
AB  - Pokazano je da statini snižavaju koncentracije inflamatornih markera, posebno visoko osetljivog C reaktivnog proteina (hsCRP), pri čemu je sniženje zavisno od doze leka. Pentraksin- 3 (PTX3) je još jedan važan inflamatorni biomarker iz porodice pentraksina koji ima prognostičke karakteristike i olakšava dijagnozu kardiovaskularnih bolesti. U ovoj studiji je ispitivan efekat terapije statinima na koncentracije PTX3 i hsCRP, kao i sinergistički efekat terapije, koncentracija PTX3 i hsCRP u snižavanju LDL-C. U studiju je uključeno 90 pacijenata kojima je koronarnom angiografijom procenjeno suženje koronarnih krvnih sudova. Rezultati su pokazali da statini smanjuju koncentraciju PTX3 (p=0,031). Koncentracije PTX3 i hsCRP značajno se razlikuju između grupa sa subkliničkim (p=0,011) i teškim oblikom stenoze (p=0,009). Primenom multiple logističke regresione analize uočena je veza između terapije statinima i niskih koncentracija PTX3 i LDL-C. Verovatnoća da će terapija statinima postići ciljne vrednosti LDL- C bila je najveća kod pacijenata sa niskim vrednostima PTX3 (OR=3,683, p=0,040), dok je multiplikativna interakcija bila 23,3. Efekat statina na sniženje PTX3 bio je veći u odnosu na efekat koji ostvaruje na hsCRP. Može se sugerisati da je terapija statinima bila uspešnija kod pacijenata sa niskim vrednostima PTX3.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?
T1  - Da li pentraksin -3 doprinosi sniženju koncentracije lipoproteina niske gustine i terapiji statinima?
VL  - 72
IS  - 2
SP  - 247
EP  - 259
DO  - 10.5937/arhfarm72-36122
ER  - 

@article{
author = "Vuković-Dejanović, Vesna and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Bogavac-Stanojević, Nataša",
year = "2022",
abstract = "Statins have been shown to decrease inflammatory markers, especially high sensitivity C reactive protein (hsCRP), in a dose-dependent manner. Pentraxin-3 (PTX3) is another important inflammatory biomarker from the pentraxin family that provides useful prognostic information and facilitates diagnostics of cardiovascular diseases. This study investigated the effect of statin therapy on PTX3 and hsCRP concentrations and whether statins acted synergistically with PTX3 and hsCRP concentrations in lowering LDL-C. The study group consisted of 90 patients undergoing coronary angiography. The results showed that statins reduced PTX3 concentrations (p=0.031). PTX3 and hsCRP levels were significantly different between subclinical and severe stenosis groups (p=0.011 and p=0.009, respectively). Statin therapy was significantly associated with lower PTX3 and LDL-C levels in multiple logistic analyses. The probability that statin therapy would achieve target LDL-C values was highest in patients with low PTX3 values (OR=3.683, p=0.040), while multiplicative interaction was 23.3. The effect of statins on PTX3 reduction was higher than on hsCRP. It can be suggested that statin therapy was more successful in patients with low PTX3 values., Pokazano je da statini snižavaju koncentracije inflamatornih markera, posebno visoko osetljivog C reaktivnog proteina (hsCRP), pri čemu je sniženje zavisno od doze leka. Pentraksin- 3 (PTX3) je još jedan važan inflamatorni biomarker iz porodice pentraksina koji ima prognostičke karakteristike i olakšava dijagnozu kardiovaskularnih bolesti. U ovoj studiji je ispitivan efekat terapije statinima na koncentracije PTX3 i hsCRP, kao i sinergistički efekat terapije, koncentracija PTX3 i hsCRP u snižavanju LDL-C. U studiju je uključeno 90 pacijenata kojima je koronarnom angiografijom procenjeno suženje koronarnih krvnih sudova. Rezultati su pokazali da statini smanjuju koncentraciju PTX3 (p=0,031). Koncentracije PTX3 i hsCRP značajno se razlikuju između grupa sa subkliničkim (p=0,011) i teškim oblikom stenoze (p=0,009). Primenom multiple logističke regresione analize uočena je veza između terapije statinima i niskih koncentracija PTX3 i LDL-C. Verovatnoća da će terapija statinima postići ciljne vrednosti LDL- C bila je najveća kod pacijenata sa niskim vrednostima PTX3 (OR=3,683, p=0,040), dok je multiplikativna interakcija bila 23,3. Efekat statina na sniženje PTX3 bio je veći u odnosu na efekat koji ostvaruje na hsCRP. Može se sugerisati da je terapija statinima bila uspešnija kod pacijenata sa niskim vrednostima PTX3.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?, Da li pentraksin -3 doprinosi sniženju koncentracije lipoproteina niske gustine i terapiji statinima?",
volume = "72",
number = "2",
pages = "247-259",
doi = "10.5937/arhfarm72-36122"
}

Vuković-Dejanović, V., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D.,& Bogavac-Stanojević, N.. (2022). Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(2), 247-259.
https://doi.org/10.5937/arhfarm72-36122

Vuković-Dejanović V, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Bogavac-Stanojević N. Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?. in Arhiv za farmaciju. 2022;72(2):247-259.
doi:10.5937/arhfarm72-36122 .

Vuković-Dejanović, Vesna, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Bogavac-Stanojević, Nataša, "Does Pentraxin-3 contribute to the reduction of low-density lipoprotein levels by statin therapy?" in Arhiv za farmaciju, 72, no. 2 (2022):247-259,
https://doi.org/10.5937/arhfarm72-36122 . .

TY  - JOUR
AU  - Ninić, Ana
AU  - Bogavac-Stanojević, Nataša
AU  - Sopić, Miron
AU  - Munjas, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Miljković, Milica
AU  - Gojković, Tamara
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3339
AB  - Background: Coronary artery disease (CAD) is one of the most important causes of mortality and morbidity in wide world population. Dyslipidemia, inflammation and oxidative stress may contribute to disruption of endothelium structure and function, atherosclerosis and CAD. Our study was aimed to determine whether Cu/Zn superoxide dismutase (Cu/Zn SOD) and Mn superoxide dismutase (Mn SOD) gene expression could be modulated by oxidative stress in CAD patients. Methods: This study included 77 CAD patients and 31 apparently healthy persons. Serum lipid levels, high sensitivity C-reactive protein (hsCRP), total antioxidant status (TAS) and thiobarbituric acid-reacting substances (TBARS) were measured. SOD isoenzymes gene expression was determined in peripheral blood mononuclear cells using quantitative polymerase chain reaction. Results: Mn SOD messenger ribonucleic acid (mRNA) levels were significantly lower in CAD patients than in controls (p=0.011), while Cu/Zn SOD mRNA levels did not change significantly between tested groups (p=0.091). We found significantly lower high-density lipoprotein-cholesterol (HDL-c) (p lt 0.001) and TAS (p lt 0.001) levels and significantly higher hsCRP (p=0.002) and TBARS (p lt 0.001) in CAD patients than in controls. There were significant positive correlations between TAS and Mn SOD mRNA (rho=0.243, p=0.020) and TAS and Cu/Zn SOD mRNA (rho=0.359, p lt 0.001). TBARS negatively correlated only with Cu/Zn SOD mRNA (rho=-0.215, p=0.040). TAS levels remained independent predictor for Mn SOD mRNA levels (OR = 2.995, p=0.034). Conclusions: Results of this study showed that Mn SOD gene expression were decreased in CAD patients compared to controls and can be modulated by nonenzymatic antioxidant status in blood.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Superoxide dismutase isoenzymes gene expression in peripheral blood mononuclear cells in patients with coronary artery disease
VL  - 38
IS  - 3
SP  - 284
EP  - 291
DO  - 10.2478/jomb-2018-0041
ER  - 

@article{
author = "Ninić, Ana and Bogavac-Stanojević, Nataša and Sopić, Miron and Munjas, Jelena and Kotur-Stevuljević, Jelena and Miljković, Milica and Gojković, Tamara and Kalimanovska-Oštrić, Dimitra and Spasojević-Kalimanovska, Vesna",
year = "2019",
abstract = "Background: Coronary artery disease (CAD) is one of the most important causes of mortality and morbidity in wide world population. Dyslipidemia, inflammation and oxidative stress may contribute to disruption of endothelium structure and function, atherosclerosis and CAD. Our study was aimed to determine whether Cu/Zn superoxide dismutase (Cu/Zn SOD) and Mn superoxide dismutase (Mn SOD) gene expression could be modulated by oxidative stress in CAD patients. Methods: This study included 77 CAD patients and 31 apparently healthy persons. Serum lipid levels, high sensitivity C-reactive protein (hsCRP), total antioxidant status (TAS) and thiobarbituric acid-reacting substances (TBARS) were measured. SOD isoenzymes gene expression was determined in peripheral blood mononuclear cells using quantitative polymerase chain reaction. Results: Mn SOD messenger ribonucleic acid (mRNA) levels were significantly lower in CAD patients than in controls (p=0.011), while Cu/Zn SOD mRNA levels did not change significantly between tested groups (p=0.091). We found significantly lower high-density lipoprotein-cholesterol (HDL-c) (p lt 0.001) and TAS (p lt 0.001) levels and significantly higher hsCRP (p=0.002) and TBARS (p lt 0.001) in CAD patients than in controls. There were significant positive correlations between TAS and Mn SOD mRNA (rho=0.243, p=0.020) and TAS and Cu/Zn SOD mRNA (rho=0.359, p lt 0.001). TBARS negatively correlated only with Cu/Zn SOD mRNA (rho=-0.215, p=0.040). TAS levels remained independent predictor for Mn SOD mRNA levels (OR = 2.995, p=0.034). Conclusions: Results of this study showed that Mn SOD gene expression were decreased in CAD patients compared to controls and can be modulated by nonenzymatic antioxidant status in blood.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Superoxide dismutase isoenzymes gene expression in peripheral blood mononuclear cells in patients with coronary artery disease",
volume = "38",
number = "3",
pages = "284-291",
doi = "10.2478/jomb-2018-0041"
}

Ninić, A., Bogavac-Stanojević, N., Sopić, M., Munjas, J., Kotur-Stevuljević, J., Miljković, M., Gojković, T., Kalimanovska-Oštrić, D.,& Spasojević-Kalimanovska, V.. (2019). Superoxide dismutase isoenzymes gene expression in peripheral blood mononuclear cells in patients with coronary artery disease. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(3), 284-291.
https://doi.org/10.2478/jomb-2018-0041

Ninić A, Bogavac-Stanojević N, Sopić M, Munjas J, Kotur-Stevuljević J, Miljković M, Gojković T, Kalimanovska-Oštrić D, Spasojević-Kalimanovska V. Superoxide dismutase isoenzymes gene expression in peripheral blood mononuclear cells in patients with coronary artery disease. in Journal of Medical Biochemistry. 2019;38(3):284-291.
doi:10.2478/jomb-2018-0041 .

Ninić, Ana, Bogavac-Stanojević, Nataša, Sopić, Miron, Munjas, Jelena, Kotur-Stevuljević, Jelena, Miljković, Milica, Gojković, Tamara, Kalimanovska-Oštrić, Dimitra, Spasojević-Kalimanovska, Vesna, "Superoxide dismutase isoenzymes gene expression in peripheral blood mononuclear cells in patients with coronary artery disease" in Journal of Medical Biochemistry, 38, no. 3 (2019):284-291,
https://doi.org/10.2478/jomb-2018-0041 . .

TY  - CONF
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Miljković, Milica
AU  - Stefanović, Aleksandra
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Đuričić, Ivana
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3071
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration
VL  - 275
SP  - e60
EP  - e60
DO  - 10.1016/j.atherosclerosis.2018.06.164
ER  - 

@conference{
author = "Gojković, Tamara and Vladimirov, Sandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Miljković, Milica and Stefanović, Aleksandra and Kalimanovska-Oštrić, Dimitra and Đuričić, Ivana and Jelić-Ivanović, Zorana",
year = "2018",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration",
volume = "275",
pages = "e60-e60",
doi = "10.1016/j.atherosclerosis.2018.06.164"
}

Gojković, T., Vladimirov, S., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Miljković, M., Stefanović, A., Kalimanovska-Oštrić, D., Đuričić, I.,& Jelić-Ivanović, Z.. (2018). Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 275, e60-e60.
https://doi.org/10.1016/j.atherosclerosis.2018.06.164

Gojković T, Vladimirov S, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Miljković M, Stefanović A, Kalimanovska-Oštrić D, Đuričić I, Jelić-Ivanović Z. Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration. in Atherosclerosis. 2018;275:e60-e60.
doi:10.1016/j.atherosclerosis.2018.06.164 .

Gojković, Tamara, Vladimirov, Sandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Miljković, Milica, Stefanović, Aleksandra, Kalimanovska-Oštrić, Dimitra, Đuričić, Ivana, Jelić-Ivanović, Zorana, "Association of statin therapy with plasma fatty acids profile and lipoprotein-associated phospholipase A2 concentration" in Atherosclerosis, 275 (2018):e60-e60,
https://doi.org/10.1016/j.atherosclerosis.2018.06.164 . .

TY  - JOUR
AU  - Munjas, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Andelković, Kristina
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2817
AB  - BackgroundAdenylate cyclase-associated protein 1 (CAP1) is a recently identified receptor for human resistin. As resistin has been related to CAD development and progression and CAP1 has never been evaluated in CAD, the aim of this study was to determine its peripheral blood mononuclear cells (PBMCs) mRNA in patients with CAD, and resistin plasma concentration, PBMCs resistin and CD36 mRNA, considering resistis ability to stimulate CD36 expression invitro. Materials and methodsThis case-controlled study included 27 healthy subjects (CG) and 66 patients requiring coronary angiography. Of the latter, 42 had nonsignificant CAD whereas 24 had significant CAD. Circulating resistin was measured by ELISA; PBMCs CAP1, resistin and CD36 mRNA were determined by real-time PCR. ResultsPatients with significant as well as patients with nonsignificant CAD had significantly higher resistin concentrations compared to the CG (P lt 0 lt bold> lt /bold>001; P=0 lt bold> lt /bold>003). Resistin mRNA did not show significant difference between the investigated groups. CAP1 and CD36 mRNA were significantly higher in significant CAD (P lt 0 lt bold> lt /bold>001; P lt 0 lt bold> lt /bold>001, respectively) and nonsignificant CAD (P lt 0 lt bold> lt /bold>001; P lt 0 lt bold> lt /bold>001, respectively) compared to the CG; significant CAD showed significantly higher CD36 mRNA (P=0 lt bold> lt /bold>040) compared to the nonsignificant CAD group. Multiple linear regression analysis identified Tg and CD36 mRNA as independent predictors of CAP1 (R-2=0 lt bold> lt /bold>402; adjR(2)=0 lt bold> lt /bold>376). ConclusionSignificant up-regulation of PBMCs CAP1, CD36 mRNA and plasma resistin found in significant CAD, as well as in nonsignificant CAD compared to CG, indicates that resistin could be able to exert its effects stronger on cells with up-regulated CAP1 mRNA thus contributing atherosclerosis development.
PB  - Wiley, Hoboken
T2  - European Journal of Clinical Investigation
T1  - Association of adenylate cyclase-associated protein 1 with coronary artery disease
VL  - 47
IS  - 9
SP  - 659
EP  - 666
DO  - 10.1111/eci.12787
ER  - 

@article{
author = "Munjas, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Andelković, Kristina and Jelić-Ivanović, Zorana",
year = "2017",
abstract = "BackgroundAdenylate cyclase-associated protein 1 (CAP1) is a recently identified receptor for human resistin. As resistin has been related to CAD development and progression and CAP1 has never been evaluated in CAD, the aim of this study was to determine its peripheral blood mononuclear cells (PBMCs) mRNA in patients with CAD, and resistin plasma concentration, PBMCs resistin and CD36 mRNA, considering resistis ability to stimulate CD36 expression invitro. Materials and methodsThis case-controlled study included 27 healthy subjects (CG) and 66 patients requiring coronary angiography. Of the latter, 42 had nonsignificant CAD whereas 24 had significant CAD. Circulating resistin was measured by ELISA; PBMCs CAP1, resistin and CD36 mRNA were determined by real-time PCR. ResultsPatients with significant as well as patients with nonsignificant CAD had significantly higher resistin concentrations compared to the CG (P lt 0 lt bold> lt /bold>001; P=0 lt bold> lt /bold>003). Resistin mRNA did not show significant difference between the investigated groups. CAP1 and CD36 mRNA were significantly higher in significant CAD (P lt 0 lt bold> lt /bold>001; P lt 0 lt bold> lt /bold>001, respectively) and nonsignificant CAD (P lt 0 lt bold> lt /bold>001; P lt 0 lt bold> lt /bold>001, respectively) compared to the CG; significant CAD showed significantly higher CD36 mRNA (P=0 lt bold> lt /bold>040) compared to the nonsignificant CAD group. Multiple linear regression analysis identified Tg and CD36 mRNA as independent predictors of CAP1 (R-2=0 lt bold> lt /bold>402; adjR(2)=0 lt bold> lt /bold>376). ConclusionSignificant up-regulation of PBMCs CAP1, CD36 mRNA and plasma resistin found in significant CAD, as well as in nonsignificant CAD compared to CG, indicates that resistin could be able to exert its effects stronger on cells with up-regulated CAP1 mRNA thus contributing atherosclerosis development.",
publisher = "Wiley, Hoboken",
journal = "European Journal of Clinical Investigation",
title = "Association of adenylate cyclase-associated protein 1 with coronary artery disease",
volume = "47",
number = "9",
pages = "659-666",
doi = "10.1111/eci.12787"
}

Munjas, J., Sopić, M., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Andelković, K.,& Jelić-Ivanović, Z.. (2017). Association of adenylate cyclase-associated protein 1 with coronary artery disease. in European Journal of Clinical Investigation
Wiley, Hoboken., 47(9), 659-666.
https://doi.org/10.1111/eci.12787

Munjas J, Sopić M, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Andelković K, Jelić-Ivanović Z. Association of adenylate cyclase-associated protein 1 with coronary artery disease. in European Journal of Clinical Investigation. 2017;47(9):659-666.
doi:10.1111/eci.12787 .

Munjas, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Andelković, Kristina, Jelić-Ivanović, Zorana, "Association of adenylate cyclase-associated protein 1 with coronary artery disease" in European Journal of Clinical Investigation, 47, no. 9 (2017):659-666,
https://doi.org/10.1111/eci.12787 . .

TY  - JOUR
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2954
AB  - Background: Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study investigates associations of different cholesterol homeostasis patterns with low-density (LDL) and high-density lipoproteins (HDL) subclasses distribution in statin-treated and statin-untreated CAD patients, and potential use of aforementioned markers for CAD treatment optimization. Methods: The study included 78 CAD patients (47 statin-untreated and 31 statin-treated) and 31 controls (CG). NCSs concentrations were quantified using gas chromatography-flame ionization detection (GC-FID). Lipoprotein subclasses were separated by gradient gel electrophoresis. Results: In patients, cholesterol-synthesis markers were significantly higher comparing to CG. Cholesterol-synthesis markers were inversely associated with LDL size in all groups. For cholesterol homeostasis estimation, each group was divided to good and/or poor synthetizers and/or absorbers according to desmosterol and beta-sitosterol median values. In CG, participants with reduced cholesterol absorption, the relative proportion of small, dense LDL was higher in those with increased cholesterol synthesis compared to those with reduced synthesis (p lt 0.01). LDL I fraction was significantly higher in poor synthetizers/poor absorbers subgroup compared to poor synthetizers/good absorbers (p lt 0.01), and good synthetizers/poor absorbers (p lt 0.01). Statin-treated patients with increased cholesterol absorption had increased proportion of LDL IVB (p lt 0.05). Conclusions: The results suggest the existence of different lipoprotein abnormalities according to various patterns of cholesterol homeostasis. Desmosterol/beta-sitosterol ratio could be used for estimating individual propensity toward dyslipidemia development and direct the future treatment.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?
VL  - 55
IS  - 3
SP  - 447
EP  - 457
DO  - 10.1515/cclm-2016-0505
ER  - 

@article{
author = "Gojković, Tamara and Vladimirov, Sandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Kalimanovska-Oštrić, Dimitra and Đuričić, Ivana and Šobajić, Slađana and Jelić-Ivanović, Zorana",
year = "2017",
abstract = "Background: Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study investigates associations of different cholesterol homeostasis patterns with low-density (LDL) and high-density lipoproteins (HDL) subclasses distribution in statin-treated and statin-untreated CAD patients, and potential use of aforementioned markers for CAD treatment optimization. Methods: The study included 78 CAD patients (47 statin-untreated and 31 statin-treated) and 31 controls (CG). NCSs concentrations were quantified using gas chromatography-flame ionization detection (GC-FID). Lipoprotein subclasses were separated by gradient gel electrophoresis. Results: In patients, cholesterol-synthesis markers were significantly higher comparing to CG. Cholesterol-synthesis markers were inversely associated with LDL size in all groups. For cholesterol homeostasis estimation, each group was divided to good and/or poor synthetizers and/or absorbers according to desmosterol and beta-sitosterol median values. In CG, participants with reduced cholesterol absorption, the relative proportion of small, dense LDL was higher in those with increased cholesterol synthesis compared to those with reduced synthesis (p lt 0.01). LDL I fraction was significantly higher in poor synthetizers/poor absorbers subgroup compared to poor synthetizers/good absorbers (p lt 0.01), and good synthetizers/poor absorbers (p lt 0.01). Statin-treated patients with increased cholesterol absorption had increased proportion of LDL IVB (p lt 0.05). Conclusions: The results suggest the existence of different lipoprotein abnormalities according to various patterns of cholesterol homeostasis. Desmosterol/beta-sitosterol ratio could be used for estimating individual propensity toward dyslipidemia development and direct the future treatment.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?",
volume = "55",
number = "3",
pages = "447-457",
doi = "10.1515/cclm-2016-0505"
}

Gojković, T., Vladimirov, S., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Kalimanovska-Oštrić, D., Đuričić, I., Šobajić, S.,& Jelić-Ivanović, Z.. (2017). Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 55(3), 447-457.
https://doi.org/10.1515/cclm-2016-0505

Gojković T, Vladimirov S, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Kalimanovska-Oštrić D, Đuričić I, Šobajić S, Jelić-Ivanović Z. Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?. in Clinical Chemistry and Laboratory Medicine. 2017;55(3):447-457.
doi:10.1515/cclm-2016-0505 .

Gojković, Tamara, Vladimirov, Sandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Kalimanovska-Oštrić, Dimitra, Đuričić, Ivana, Šobajić, Slađana, Jelić-Ivanović, Zorana, "Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?" in Clinical Chemistry and Laboratory Medicine, 55, no. 3 (2017):447-457,
https://doi.org/10.1515/cclm-2016-0505 . .

TY  - CONF
AU  - Vladimirov, Sandra
AU  - Gojković, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2828
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Influence of LCAT and CETP activity on the reverse cholesterol transport and modification of HDL particles in statin-treated coronary artery disease patients and healthy subjects
VL  - 263
SP  - e217
EP  - e217
DO  - 10.1016/j.atherosclerosis.2017.06.708
ER  - 

@conference{
author = "Vladimirov, Sandra and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana",
year = "2017",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Influence of LCAT and CETP activity on the reverse cholesterol transport and modification of HDL particles in statin-treated coronary artery disease patients and healthy subjects",
volume = "263",
pages = "e217-e217",
doi = "10.1016/j.atherosclerosis.2017.06.708"
}

Vladimirov, S., Gojković, T., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Kalimanovska-Oštrić, D.,& Jelić-Ivanović, Z.. (2017). Influence of LCAT and CETP activity on the reverse cholesterol transport and modification of HDL particles in statin-treated coronary artery disease patients and healthy subjects. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 263, e217-e217.
https://doi.org/10.1016/j.atherosclerosis.2017.06.708

Vladimirov S, Gojković T, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Kalimanovska-Oštrić D, Jelić-Ivanović Z. Influence of LCAT and CETP activity on the reverse cholesterol transport and modification of HDL particles in statin-treated coronary artery disease patients and healthy subjects. in Atherosclerosis. 2017;263:e217-e217.
doi:10.1016/j.atherosclerosis.2017.06.708 .

Vladimirov, Sandra, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, "Influence of LCAT and CETP activity on the reverse cholesterol transport and modification of HDL particles in statin-treated coronary artery disease patients and healthy subjects" in Atherosclerosis, 263 (2017):e217-e217,
https://doi.org/10.1016/j.atherosclerosis.2017.06.708 . .

TY  - CONF
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Jelić-Ivanović, Zorana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2805
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of LDL phenotypes with cholesterol synthesis and HDL subclasses in statin-treated coronary artery disease patients and healthy subjects
VL  - 263
SP  - e205
EP  - e205
DO  - 10.1016/j.atherosclerosis.2017.06.664
ER  - 

@conference{
author = "Gojković, Tamara and Vladimirov, Sandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana",
year = "2017",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of LDL phenotypes with cholesterol synthesis and HDL subclasses in statin-treated coronary artery disease patients and healthy subjects",
volume = "263",
pages = "e205-e205",
doi = "10.1016/j.atherosclerosis.2017.06.664"
}

Gojković, T., Vladimirov, S., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Kalimanovska-Oštrić, D.,& Jelić-Ivanović, Z.. (2017). Association of LDL phenotypes with cholesterol synthesis and HDL subclasses in statin-treated coronary artery disease patients and healthy subjects. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 263, e205-e205.
https://doi.org/10.1016/j.atherosclerosis.2017.06.664

Gojković T, Vladimirov S, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Kalimanovska-Oštrić D, Jelić-Ivanović Z. Association of LDL phenotypes with cholesterol synthesis and HDL subclasses in statin-treated coronary artery disease patients and healthy subjects. in Atherosclerosis. 2017;263:e205-e205.
doi:10.1016/j.atherosclerosis.2017.06.664 .

Gojković, Tamara, Vladimirov, Sandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, "Association of LDL phenotypes with cholesterol synthesis and HDL subclasses in statin-treated coronary artery disease patients and healthy subjects" in Atherosclerosis, 263 (2017):e205-e205,
https://doi.org/10.1016/j.atherosclerosis.2017.06.664 . .

TY  - JOUR
AU  - Joksić, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Gojković, Tamara
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Anđelković, Kristina
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2575
AB  - Recent in vitro experiments have indicated that human resistin increases the number of lipoprotein particles secreted by the human hepatocytes and also influences their quality, in terms of generating more proatherogenic lipid particles. The aim of this study is to investigate associations of plasma resistin and peripheral blood mononuclear cells (PBMCs) resistin messenger RNA (mRNA) levels with different prevalence of small, dense low-density lipoprotein particles (sdLDL) in patients with indications for coronary angiography. This study included 65 patients requiring coronary angiography. There were 41 patients without significant stenosis and 24 patients with significant stenosis in at least one major coronary artery. Circulating resistin was measured by enzyme-linked immunosorbent assay; PBMC resistin mRNA was determined by real-time polymerase chain reaction. The LDL and high density lipoprotein subclasses were determined by gradient gel electrophoresis. Plasma resistin (P = 0.031) and PBMCs resistin mRNA (P = 0.004) were significantly higher in patients with proportion of sdLDL particles >= 50%, compared to the group with relative proportion of sdLDL particles  lt  50%. Plasma resistin correlated positively with creatinine (r = 0.456, P  lt  0.001) and resistin mRNA (r = 0.298, P = 0.014) but negatively with body mass index (r = -0.254, P = 0.034) and total cholesterol (r = -0.286, P = 0.021). Multiple linear regression analysis revealed LDL particle diameter as the only independent predictor of resistin mRNA (R-2 = 0.258; adjR(2) = 0.190). A significant association between resistin, both PBMCs mRNA and plasma protein, and the relative proportion of sdLDL particles in the circulation of coronary artery disease patients has been established, which implies that increased gene expression of resistin in PBMCs and higher resistin concentration in plasma are related to pro-atherogenic LDL particle phenotype.
PB  - Wiley, Hoboken
T2  - Clinical and Experimental Pharmacology and Physiology
T1  - Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients
VL  - 43
IS  - 1
SP  - 22
EP  - 28
DO  - 10.1111/1440-1681.12503
ER  - 

@article{
author = "Joksić, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Gojković, Tamara and Zeljković, Aleksandra and Vekić, Jelena and Anđelković, Kristina and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Recent in vitro experiments have indicated that human resistin increases the number of lipoprotein particles secreted by the human hepatocytes and also influences their quality, in terms of generating more proatherogenic lipid particles. The aim of this study is to investigate associations of plasma resistin and peripheral blood mononuclear cells (PBMCs) resistin messenger RNA (mRNA) levels with different prevalence of small, dense low-density lipoprotein particles (sdLDL) in patients with indications for coronary angiography. This study included 65 patients requiring coronary angiography. There were 41 patients without significant stenosis and 24 patients with significant stenosis in at least one major coronary artery. Circulating resistin was measured by enzyme-linked immunosorbent assay; PBMC resistin mRNA was determined by real-time polymerase chain reaction. The LDL and high density lipoprotein subclasses were determined by gradient gel electrophoresis. Plasma resistin (P = 0.031) and PBMCs resistin mRNA (P = 0.004) were significantly higher in patients with proportion of sdLDL particles >= 50%, compared to the group with relative proportion of sdLDL particles  lt  50%. Plasma resistin correlated positively with creatinine (r = 0.456, P  lt  0.001) and resistin mRNA (r = 0.298, P = 0.014) but negatively with body mass index (r = -0.254, P = 0.034) and total cholesterol (r = -0.286, P = 0.021). Multiple linear regression analysis revealed LDL particle diameter as the only independent predictor of resistin mRNA (R-2 = 0.258; adjR(2) = 0.190). A significant association between resistin, both PBMCs mRNA and plasma protein, and the relative proportion of sdLDL particles in the circulation of coronary artery disease patients has been established, which implies that increased gene expression of resistin in PBMCs and higher resistin concentration in plasma are related to pro-atherogenic LDL particle phenotype.",
publisher = "Wiley, Hoboken",
journal = "Clinical and Experimental Pharmacology and Physiology",
title = "Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients",
volume = "43",
number = "1",
pages = "22-28",
doi = "10.1111/1440-1681.12503"
}

Joksić, J., Sopić, M., Spasojević-Kalimanovska, V., Gojković, T., Zeljković, A., Vekić, J., Anđelković, K., Kalimanovska-Oštrić, D.,& Jelić-Ivanović, Z.. (2016). Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients. in Clinical and Experimental Pharmacology and Physiology
Wiley, Hoboken., 43(1), 22-28.
https://doi.org/10.1111/1440-1681.12503

Joksić J, Sopić M, Spasojević-Kalimanovska V, Gojković T, Zeljković A, Vekić J, Anđelković K, Kalimanovska-Oštrić D, Jelić-Ivanović Z. Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients. in Clinical and Experimental Pharmacology and Physiology. 2016;43(1):22-28.
doi:10.1111/1440-1681.12503 .

Joksić, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Gojković, Tamara, Zeljković, Aleksandra, Vekić, Jelena, Anđelković, Kristina, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, "Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients" in Clinical and Experimental Pharmacology and Physiology, 43, no. 1 (2016):22-28,
https://doi.org/10.1111/1440-1681.12503 . .

TY  - CONF
AU  - Vladimirov, Sandra
AU  - Gojković, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2616
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of different cholesterol homeostasis patterns with abdominal obesity in patients with coronary artery disease
VL  - 252
SP  - e145
EP  - e145
DO  - 10.1016/j.atherosclerosis.2016.07.718
ER  - 

@conference{
author = "Vladimirov, Sandra and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of different cholesterol homeostasis patterns with abdominal obesity in patients with coronary artery disease",
volume = "252",
pages = "e145-e145",
doi = "10.1016/j.atherosclerosis.2016.07.718"
}

Vladimirov, S., Gojković, T., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Kalimanovska-Oštrić, D.,& Jelić-Ivanović, Z.. (2016). Association of different cholesterol homeostasis patterns with abdominal obesity in patients with coronary artery disease. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 252, e145-e145.
https://doi.org/10.1016/j.atherosclerosis.2016.07.718

Vladimirov S, Gojković T, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Kalimanovska-Oštrić D, Jelić-Ivanović Z. Association of different cholesterol homeostasis patterns with abdominal obesity in patients with coronary artery disease. in Atherosclerosis. 2016;252:e145-e145.
doi:10.1016/j.atherosclerosis.2016.07.718 .

Vladimirov, Sandra, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, "Association of different cholesterol homeostasis patterns with abdominal obesity in patients with coronary artery disease" in Atherosclerosis, 252 (2016):e145-e145,
https://doi.org/10.1016/j.atherosclerosis.2016.07.718 . .

TY  - CONF
AU  - Sopić, Miron
AU  - Joksić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Andelković, Kristina
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2646
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease
VL  - 252
SP  - e246
EP  - e247
DO  - 10.1016/j.atherosclerosis.2016.07.046
ER  - 

@conference{
author = "Sopić, Miron and Joksić, Jelena and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Andelković, Kristina and Jelić-Ivanović, Zorana",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease",
volume = "252",
pages = "e246-e247",
doi = "10.1016/j.atherosclerosis.2016.07.046"
}

Sopić, M., Joksić, J., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Andelković, K.,& Jelić-Ivanović, Z.. (2016). Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 252, e246-e247.
https://doi.org/10.1016/j.atherosclerosis.2016.07.046

Sopić M, Joksić J, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Andelković K, Jelić-Ivanović Z. Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease. in Atherosclerosis. 2016;252:e246-e247.
doi:10.1016/j.atherosclerosis.2016.07.046 .

Sopić, Miron, Joksić, Jelena, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Andelković, Kristina, Jelić-Ivanović, Zorana, "Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease" in Atherosclerosis, 252 (2016):e246-e247,
https://doi.org/10.1016/j.atherosclerosis.2016.07.046 . .

TY  - CONF
AU  - Gojković, Tamara
AU  - Vladimirov, Sandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2617
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?
VL  - 252
SP  - e6
EP  - e6
DO  - 10.1016/j.atherosclerosis.2016.07.251
ER  - 

@conference{
author = "Gojković, Tamara and Vladimirov, Sandra and Spasojević-Kalimanovska, Vesna and Zeljković, Aleksandra and Vekić, Jelena and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?",
volume = "252",
pages = "e6-e6",
doi = "10.1016/j.atherosclerosis.2016.07.251"
}

Gojković, T., Vladimirov, S., Spasojević-Kalimanovska, V., Zeljković, A., Vekić, J., Kalimanovska-Oštrić, D.,& Jelić-Ivanović, Z.. (2016). Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 252, e6-e6.
https://doi.org/10.1016/j.atherosclerosis.2016.07.251

Gojković T, Vladimirov S, Spasojević-Kalimanovska V, Zeljković A, Vekić J, Kalimanovska-Oštrić D, Jelić-Ivanović Z. Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?. in Atherosclerosis. 2016;252:e6-e6.
doi:10.1016/j.atherosclerosis.2016.07.251 .

Gojković, Tamara, Vladimirov, Sandra, Spasojević-Kalimanovska, Vesna, Zeljković, Aleksandra, Vekić, Jelena, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, "Can non-cholesterol sterols and lipoprotein subclasses distribution predict different patterns of cholesterol metabolism and statin therapy response?" in Atherosclerosis, 252 (2016):e6-e6,
https://doi.org/10.1016/j.atherosclerosis.2016.07.251 . .

TY  - JOUR
AU  - Joksić, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Anđelković, Kristina
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2465
AB  - Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P = 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P  lt  0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.
PB  - Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb
T2  - Biochemia Medica
T1  - Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease
VL  - 25
IS  - 2
SP  - 242
EP  - 251
DO  - 10.11613/BM.2015.025
ER  - 

@article{
author = "Joksić, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Anđelković, Kristina and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P = 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P  lt  0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.",
publisher = "Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb",
journal = "Biochemia Medica",
title = "Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease",
volume = "25",
number = "2",
pages = "242-251",
doi = "10.11613/BM.2015.025"
}

Joksić, J., Sopić, M., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Anđelković, K.,& Jelić-Ivanović, Z.. (2015). Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease. in Biochemia Medica
Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb., 25(2), 242-251.
https://doi.org/10.11613/BM.2015.025

Joksić J, Sopić M, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Anđelković K, Jelić-Ivanović Z. Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease. in Biochemia Medica. 2015;25(2):242-251.
doi:10.11613/BM.2015.025 .

Joksić, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Anđelković, Kristina, Jelić-Ivanović, Zorana, "Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease" in Biochemia Medica, 25, no. 2 (2015):242-251,
https://doi.org/10.11613/BM.2015.025 . .

TY  - CONF
AU  - Sopić, Miron
AU  - Joksić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Gojković, Tamara
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2443
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease
VL  - 241
IS  - 1
SP  - e151
EP  - e151
DO  - 10.1016/j.atherosclerosis.2015.04.770
ER  - 

@conference{
author = "Sopić, Miron and Joksić, Jelena and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Gojković, Tamara and Zeljković, Aleksandra and Vekić, Jelena and Jelić-Ivanović, Zorana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease",
volume = "241",
number = "1",
pages = "e151-e151",
doi = "10.1016/j.atherosclerosis.2015.04.770"
}

Sopić, M., Joksić, J., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Gojković, T., Zeljković, A., Vekić, J.,& Jelić-Ivanović, Z.. (2015). Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 241(1), e151-e151.
https://doi.org/10.1016/j.atherosclerosis.2015.04.770

Sopić M, Joksić J, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Gojković T, Zeljković A, Vekić J, Jelić-Ivanović Z. Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease. in Atherosclerosis. 2015;241(1):e151-e151.
doi:10.1016/j.atherosclerosis.2015.04.770 .

Sopić, Miron, Joksić, Jelena, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Gojković, Tamara, Zeljković, Aleksandra, Vekić, Jelena, Jelić-Ivanović, Zorana, "Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease" in Atherosclerosis, 241, no. 1 (2015):e151-e151,
https://doi.org/10.1016/j.atherosclerosis.2015.04.770 . .

TY  - JOUR
AU  - Vuković-Dejanović, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Topalović, Mirko
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2324
AB  - Background: We compared factors of inflammation high sensitivity C-reactive protein (hsCRP) and pentraxin-3 (PTX3), and we explored their relationship with coronary artery disease (CAD). Also, we tested the usefulness of hsCRP and PTX3 in the risk assessment of coronary stenosis development and the diagnostic ability of these biomarkers to detect disease severity. Methods: The study group consisted of 93 CAD patients undergoing coronary angiography. Patients were divided into CAD(0), representing subclinical stenosis, and CAD (1-3), representing significant stenosis in one, two or three vessels. Results: We determined the concentration of lipid status parameters, hsCRP and PTX3. We found significantly lower PTX3 and hsCRP concentrations in CAD(0) than in CAD(1-3) group. Concentration of PTX3 showed an increasing trend with the increasing number of vessels affected. The area under ROC curve (AUC) for the combinations of hsCRP and PTX3 with lipid parameters had useful accuracy for detecting CAD(1-3) patients (AUC=0.770, p lt 0.001). Conclusion: PTX3 is a promising independent diagnostic marker for identifying patients with CAD, and a useful indicator of disease progression. In all the analyses PTX3 showed better performance than hsCRP. A combination of PTX3, hsCRP with the lipid status parameters provides risk stratification of the development of coronary stenosis and better classification than their individual application.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography
VL  - 34
IS  - 4
SP  - 440
EP  - 449
DO  - 10.2478/jomb-2014-0061
ER  - 

@article{
author = "Vuković-Dejanović, Vesna and Bogavac-Stanojević, Nataša and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Topalović, Mirko and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Background: We compared factors of inflammation high sensitivity C-reactive protein (hsCRP) and pentraxin-3 (PTX3), and we explored their relationship with coronary artery disease (CAD). Also, we tested the usefulness of hsCRP and PTX3 in the risk assessment of coronary stenosis development and the diagnostic ability of these biomarkers to detect disease severity. Methods: The study group consisted of 93 CAD patients undergoing coronary angiography. Patients were divided into CAD(0), representing subclinical stenosis, and CAD (1-3), representing significant stenosis in one, two or three vessels. Results: We determined the concentration of lipid status parameters, hsCRP and PTX3. We found significantly lower PTX3 and hsCRP concentrations in CAD(0) than in CAD(1-3) group. Concentration of PTX3 showed an increasing trend with the increasing number of vessels affected. The area under ROC curve (AUC) for the combinations of hsCRP and PTX3 with lipid parameters had useful accuracy for detecting CAD(1-3) patients (AUC=0.770, p lt 0.001). Conclusion: PTX3 is a promising independent diagnostic marker for identifying patients with CAD, and a useful indicator of disease progression. In all the analyses PTX3 showed better performance than hsCRP. A combination of PTX3, hsCRP with the lipid status parameters provides risk stratification of the development of coronary stenosis and better classification than their individual application.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography",
volume = "34",
number = "4",
pages = "440-449",
doi = "10.2478/jomb-2014-0061"
}

Vuković-Dejanović, V., Bogavac-Stanojević, N., Spasić, S., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Topalović, M.,& Jelić-Ivanović, Z.. (2015). Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 34(4), 440-449.
https://doi.org/10.2478/jomb-2014-0061

Vuković-Dejanović V, Bogavac-Stanojević N, Spasić S, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Topalović M, Jelić-Ivanović Z. Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography. in Journal of Medical Biochemistry. 2015;34(4):440-449.
doi:10.2478/jomb-2014-0061 .

Vuković-Dejanović, Vesna, Bogavac-Stanojević, Nataša, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Topalović, Mirko, Jelić-Ivanović, Zorana, "Association of Serum Pentraxin-3 and High-Sensitivity C-Reactive Protein with the Extent of Coronary Stenosis in Patients Undergoing Coronary Angiography" in Journal of Medical Biochemistry, 34, no. 4 (2015):440-449,
https://doi.org/10.2478/jomb-2014-0061 . .

TY  - JOUR
AU  - Sopić, Miron
AU  - Joksić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Andelković, Kristina
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2417
AB  - The aim of the present study was to investigate if circulating adiponectin levels and the expression of AdipoR1 and AdipoR2 in peripheral blood mononuclear cells (PBMC) are altered in coronary artery disease (CAD) patients, with and without significant stenosis, compared to healthy patients. The present study included 69 patients with presenting symptoms of CAD (26 patients with significant stenosis and 43 patients without significant stenosis). The control group (CG) consisted of 33 healthy patients. Circulating adiponectin levels were measured by enzyme-linked immunosorbent assay, whereas AdipoR1 and AdipoR2 mRNA levels in PBMC were determined by real-time polymerase chain reaction. Adiponectin levels were significantly higher in patients with and without significant stenosis compared to the CG (P lt 0.001 vs P=0.006, respectively). Both patient groups had lower AdipoR1 levels compared to the CG (P lt 0.001 vs P lt 0.001, respectively). There were no significant differences in these parameters between the two patient groups. Adiponectin negatively correlated with body mass index, triglycerides, insulin and homeostasis model assessment of insulin resistance index (HOMA IR), and positively with high-denisty lipoprotein cholesterol in the CG. Glucose, insulin, and the HOMA IR index negatively correlated with adiponectin in patients. A positive correlation between adiponectin receptors was found in patients and the CG. Decreased AdipoR1 mRNA levels and increased circulating adiponectin in advanced stages of CAD, as well as in patients without significant stenosis, compared to the CG, implies that CAD could be related to adiponectin resistance'. Despite increased adiponectin, its protective effects could be diminished even in early stages of atherosclerosis.
PB  - Wiley, Hoboken
T2  - Clinical and Experimental Pharmacology and Physiology
T1  - Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?
VL  - 42
IS  - 4
SP  - 331
EP  - 336
DO  - 10.1111/1440-1681.12361
ER  - 

@article{
author = "Sopić, Miron and Joksić, Jelena and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Andelković, Kristina and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "The aim of the present study was to investigate if circulating adiponectin levels and the expression of AdipoR1 and AdipoR2 in peripheral blood mononuclear cells (PBMC) are altered in coronary artery disease (CAD) patients, with and without significant stenosis, compared to healthy patients. The present study included 69 patients with presenting symptoms of CAD (26 patients with significant stenosis and 43 patients without significant stenosis). The control group (CG) consisted of 33 healthy patients. Circulating adiponectin levels were measured by enzyme-linked immunosorbent assay, whereas AdipoR1 and AdipoR2 mRNA levels in PBMC were determined by real-time polymerase chain reaction. Adiponectin levels were significantly higher in patients with and without significant stenosis compared to the CG (P lt 0.001 vs P=0.006, respectively). Both patient groups had lower AdipoR1 levels compared to the CG (P lt 0.001 vs P lt 0.001, respectively). There were no significant differences in these parameters between the two patient groups. Adiponectin negatively correlated with body mass index, triglycerides, insulin and homeostasis model assessment of insulin resistance index (HOMA IR), and positively with high-denisty lipoprotein cholesterol in the CG. Glucose, insulin, and the HOMA IR index negatively correlated with adiponectin in patients. A positive correlation between adiponectin receptors was found in patients and the CG. Decreased AdipoR1 mRNA levels and increased circulating adiponectin in advanced stages of CAD, as well as in patients without significant stenosis, compared to the CG, implies that CAD could be related to adiponectin resistance'. Despite increased adiponectin, its protective effects could be diminished even in early stages of atherosclerosis.",
publisher = "Wiley, Hoboken",
journal = "Clinical and Experimental Pharmacology and Physiology",
title = "Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?",
volume = "42",
number = "4",
pages = "331-336",
doi = "10.1111/1440-1681.12361"
}

Sopić, M., Joksić, J., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Andelković, K.,& Jelić-Ivanović, Z.. (2015). Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?. in Clinical and Experimental Pharmacology and Physiology
Wiley, Hoboken., 42(4), 331-336.
https://doi.org/10.1111/1440-1681.12361

Sopić M, Joksić J, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Andelković K, Jelić-Ivanović Z. Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?. in Clinical and Experimental Pharmacology and Physiology. 2015;42(4):331-336.
doi:10.1111/1440-1681.12361 .

Sopić, Miron, Joksić, Jelena, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Andelković, Kristina, Jelić-Ivanović, Zorana, "Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?" in Clinical and Experimental Pharmacology and Physiology, 42, no. 4 (2015):331-336,
https://doi.org/10.1111/1440-1681.12361 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Memon, Lidija
AU  - Bogavac-Stanojević, Nataša
AU  - Topić, Aleksandra
AU  - Spasić, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2164
AB  - Background A research on novel cardiovascular risk factors is mainly focused on patients with clinically verified coronary artery disease (CAD), while less is known about their presence in symptomatic patients, but without angiographically proven occlusion of coronary arteries. The aim of this study was to compare plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in stable angina patients with and without significant obstructive CAD. Methods LDL and HDL subclasses were analysed in 100 stable angina patients with >= 50% of obstruction and 40 patients with less than 50% of luminal narrowing, as assessed by coronary angiography. Results Patients with  lt 50% of obstruction had reduced mean HDL size and higher proportion of small HDL particles (P  lt  0.05). HDL size and proportion of small HDL particles were significant and independent predictors of obstructive CAD (P  lt  0.05, respectively). Conclusions Stable angina patients with
PB  - Sage Publications Inc, Thousand Oaks
T2  - Annals of Clinical Biochemistry
T1  - Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients
VL  - 51
IS  - 3
SP  - 412
EP  - 415
DO  - 10.1177/0004563213499908
ER  - 

@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Kalimanovska-Oštrić, Dimitra and Memon, Lidija and Bogavac-Stanojević, Nataša and Topić, Aleksandra and Spasić, Slavica",
year = "2014",
abstract = "Background A research on novel cardiovascular risk factors is mainly focused on patients with clinically verified coronary artery disease (CAD), while less is known about their presence in symptomatic patients, but without angiographically proven occlusion of coronary arteries. The aim of this study was to compare plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in stable angina patients with and without significant obstructive CAD. Methods LDL and HDL subclasses were analysed in 100 stable angina patients with >= 50% of obstruction and 40 patients with less than 50% of luminal narrowing, as assessed by coronary angiography. Results Patients with  lt 50% of obstruction had reduced mean HDL size and higher proportion of small HDL particles (P  lt  0.05). HDL size and proportion of small HDL particles were significant and independent predictors of obstructive CAD (P  lt  0.05, respectively). Conclusions Stable angina patients with",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Annals of Clinical Biochemistry",
title = "Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients",
volume = "51",
number = "3",
pages = "412-415",
doi = "10.1177/0004563213499908"
}

Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Kalimanovska-Oštrić, D., Memon, L., Bogavac-Stanojević, N., Topić, A.,& Spasić, S.. (2014). Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients. in Annals of Clinical Biochemistry
Sage Publications Inc, Thousand Oaks., 51(3), 412-415.
https://doi.org/10.1177/0004563213499908

Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Kalimanovska-Oštrić D, Memon L, Bogavac-Stanojević N, Topić A, Spasić S. Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients. in Annals of Clinical Biochemistry. 2014;51(3):412-415.
doi:10.1177/0004563213499908 .

Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Kalimanovska-Oštrić, Dimitra, Memon, Lidija, Bogavac-Stanojević, Nataša, Topić, Aleksandra, Spasić, Slavica, "Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients" in Annals of Clinical Biochemistry, 51, no. 3 (2014):412-415,
https://doi.org/10.1177/0004563213499908 . .

TY  - JOUR
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Memon, Lidija
AU  - Spasić, Slavica
AU  - Kotur-Stevuljević, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2236
AB  - Objectives: Epidemiological evidence concerning the role of iron, a lipid peroxidation catalyst, in atherosclerosis and coronary artery disease (CAD) is inconsistent. Design and methods: Exploratory factor analysis was used to examine the potential clustering of variables known to be associated with CAD using data from 188 patients with angiographically-approved disease. The resulting factors were then tested for their association with serum ferritin and soluble transferrin receptor (sTfR) as indicators of body iron status. Results: Factor analysis resulted in a reduction of a variable number from the original 15 to 5 composite clusters. These factors were interpreted as (1) "proatherogenic factor" with positive loadings of TC, LDL-C, apoB and TG; (2) "inflammatory factor" with positive loadings of hsCRP, fibrinogen and MDA; (3) "antiatherogenic factor" with positive loadings of HDL-C and apoA-I; (4) "obesity factor" with positive loadings of weight and waist; and (5) "antioxidative status factor" with positive loadings of SOD and age and negative loading of superoxide anion. "Inflammatory", "obesity" and "antiatherogenic" factors predicted high ferritin values and the "proatherogenic factor" predicted high sTfR values. We compared the ability of the "proatherogenic factor" with that of a multi-variable logistic model that included the "proatherogenic factor" and sTfR values in predicting significant stenosis in patients. The area under the ROC curve was 0.692 vs. 0.821, respectively. Conclusions: "Inflammatory", "obesity", "antiatherogenic" and "proatherogenic" factors were associated with increased parameters of body iron status. The measurement of sTfR improves the prediction of CAD based on clustered cardiovascular risk factors.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Factor analysis of risk variables associated with iron status in patients with coronary artery disease
VL  - 47
IS  - 7-8
SP  - 564
EP  - 569
DO  - 10.1016/j.clinbiochem.2014.03.014
ER  - 

@article{
author = "Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kalimanovska-Oštrić, Dimitra and Memon, Lidija and Spasić, Slavica and Kotur-Stevuljević, Jelena and Jelić-Ivanović, Zorana",
year = "2014",
abstract = "Objectives: Epidemiological evidence concerning the role of iron, a lipid peroxidation catalyst, in atherosclerosis and coronary artery disease (CAD) is inconsistent. Design and methods: Exploratory factor analysis was used to examine the potential clustering of variables known to be associated with CAD using data from 188 patients with angiographically-approved disease. The resulting factors were then tested for their association with serum ferritin and soluble transferrin receptor (sTfR) as indicators of body iron status. Results: Factor analysis resulted in a reduction of a variable number from the original 15 to 5 composite clusters. These factors were interpreted as (1) "proatherogenic factor" with positive loadings of TC, LDL-C, apoB and TG; (2) "inflammatory factor" with positive loadings of hsCRP, fibrinogen and MDA; (3) "antiatherogenic factor" with positive loadings of HDL-C and apoA-I; (4) "obesity factor" with positive loadings of weight and waist; and (5) "antioxidative status factor" with positive loadings of SOD and age and negative loading of superoxide anion. "Inflammatory", "obesity" and "antiatherogenic" factors predicted high ferritin values and the "proatherogenic factor" predicted high sTfR values. We compared the ability of the "proatherogenic factor" with that of a multi-variable logistic model that included the "proatherogenic factor" and sTfR values in predicting significant stenosis in patients. The area under the ROC curve was 0.692 vs. 0.821, respectively. Conclusions: "Inflammatory", "obesity", "antiatherogenic" and "proatherogenic" factors were associated with increased parameters of body iron status. The measurement of sTfR improves the prediction of CAD based on clustered cardiovascular risk factors.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Factor analysis of risk variables associated with iron status in patients with coronary artery disease",
volume = "47",
number = "7-8",
pages = "564-569",
doi = "10.1016/j.clinbiochem.2014.03.014"
}

Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kalimanovska-Oštrić, D., Memon, L., Spasić, S., Kotur-Stevuljević, J.,& Jelić-Ivanović, Z.. (2014). Factor analysis of risk variables associated with iron status in patients with coronary artery disease. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 47(7-8), 564-569.
https://doi.org/10.1016/j.clinbiochem.2014.03.014

Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kalimanovska-Oštrić D, Memon L, Spasić S, Kotur-Stevuljević J, Jelić-Ivanović Z. Factor analysis of risk variables associated with iron status in patients with coronary artery disease. in Clinical Biochemistry. 2014;47(7-8):564-569.
doi:10.1016/j.clinbiochem.2014.03.014 .

Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kalimanovska-Oštrić, Dimitra, Memon, Lidija, Spasić, Slavica, Kotur-Stevuljević, Jelena, Jelić-Ivanović, Zorana, "Factor analysis of risk variables associated with iron status in patients with coronary artery disease" in Clinical Biochemistry, 47, no. 7-8 (2014):564-569,
https://doi.org/10.1016/j.clinbiochem.2014.03.014 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Bogavac-Stanojević, Nataša
AU  - Spasić, Slavica
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1783
AB  - Alterations in serum lipoprotein levels contribute to the progression of atherosclerosis in coronary artery disease (CAD). Screening for the presence of small, dense low-density (LDL) and high-density lipoprotein (HDL) particles and identification of the factors affecting their excessive production, could have beneficial effects on reducing the risk of future cardiovascular events. In this study, we investigated the effect of serum triglyceride concentration on LDL and HDL size and subclasses in 181 CAD patients and 178 healthy controls. LDL and HDL particles were separated by polyacrylamide gradient gel electrophoresis, while serum lipid parameters were determined by routine laboratory methods. CAD patients had significantly smaller LDL and HDL particle sizes (P lt 0.001), more LDL III, but less HDL 2b subclasses (P lt 0.05) than controls. In CAD group, higher TG levels were associated with smaller LDL and HDL sizes and lower proportions of LDL I subclasses. Patients with hypertriglyceridemia had reduced LDL diameters (P lt 0.01) and higher proportions of small, dense LDL particles (P lt 0.05) than normotrigliceridemic patients. In addition, hypertriglyceridemic patients had HDL subclasses distribution shifted towards smaller particles. Our results indicate that serum TG level is the main lipid risk factor that determines the amount of small, dense LDL and HDL particles in CAD.
AB  - Poremećaji koncentracije lipoproteina doprinose progresiji ateroskleroze u koronarnoj arterijskoj bolesti (KAB). Ispitivanjem zastupljenosti malih, gustih čestica lipoproteina niske (LDL) i visoke gustine (HDL), kao i otkrivanjem faktora koji utiču na njihovo povećano stvaranje, moguće je smanjiti rizik za pojavu budućih kardiovaskularnih događaja. U ovoj studiji ispitivali smo uticaj koncentracije triglicerida (TG) na veličinu i raspodelu LDL i HDL subfrakcija kod 181 pacijenta sa KAB i 178 zdravih osoba. LDL i HDL subfrakcije su razdvojene metodom vertikalne elektroforeze na gradijentu poliakrilamida, a koncentracije lipidnih parametara su određene rutinskim laboratorijskim metodama. Utvrdili smo da KAB pacijenti imaju značajno manje dijametre LDL i HDL čestica (P lt 0,001), veći udeo LDL III, a manje HDL 2b subfrakcija (P lt 0,05). U KAB grupi povišena koncentracija TG bila je u korelaciji sa manjim LDL i HDL dijametrima i nižim udelom LDL I subfrakcija. Pacijenti sa hipertrigliceridemijom imali su manje LDL dijametre (P lt 0,01) i veći udeo malih, gustih LDL čestica (P lt 0,05) u odnosu na normotrigliceridemične pacijente. Sem toga, kod pacijenata sa hipertrigliceridemijom uočena je preraspodela HDL subfrakcija ka manjim česticama. Naši rezultati ukazuju da je koncentracija TG u serumu glavni lipidni faktor rizika koji determiniše količinu malih, gustih LDL i HDL čestica u KAB.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Influence of hypertrigliceridemia on small, dense LDL and HDL particles in coronary artery disease
T1  - Uticaj hipertrigliceridemije na male, guste LDL i HDL čestice u koronarnoj arterijskoj bolesti
VL  - 62
IS  - 5
SP  - 461
EP  - 474
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1783
ER  - 

@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Bogavac-Stanojević, Nataša and Spasić, Slavica and Kalimanovska-Oštrić, Dimitra",
year = "2012",
abstract = "Alterations in serum lipoprotein levels contribute to the progression of atherosclerosis in coronary artery disease (CAD). Screening for the presence of small, dense low-density (LDL) and high-density lipoprotein (HDL) particles and identification of the factors affecting their excessive production, could have beneficial effects on reducing the risk of future cardiovascular events. In this study, we investigated the effect of serum triglyceride concentration on LDL and HDL size and subclasses in 181 CAD patients and 178 healthy controls. LDL and HDL particles were separated by polyacrylamide gradient gel electrophoresis, while serum lipid parameters were determined by routine laboratory methods. CAD patients had significantly smaller LDL and HDL particle sizes (P lt 0.001), more LDL III, but less HDL 2b subclasses (P lt 0.05) than controls. In CAD group, higher TG levels were associated with smaller LDL and HDL sizes and lower proportions of LDL I subclasses. Patients with hypertriglyceridemia had reduced LDL diameters (P lt 0.01) and higher proportions of small, dense LDL particles (P lt 0.05) than normotrigliceridemic patients. In addition, hypertriglyceridemic patients had HDL subclasses distribution shifted towards smaller particles. Our results indicate that serum TG level is the main lipid risk factor that determines the amount of small, dense LDL and HDL particles in CAD., Poremećaji koncentracije lipoproteina doprinose progresiji ateroskleroze u koronarnoj arterijskoj bolesti (KAB). Ispitivanjem zastupljenosti malih, gustih čestica lipoproteina niske (LDL) i visoke gustine (HDL), kao i otkrivanjem faktora koji utiču na njihovo povećano stvaranje, moguće je smanjiti rizik za pojavu budućih kardiovaskularnih događaja. U ovoj studiji ispitivali smo uticaj koncentracije triglicerida (TG) na veličinu i raspodelu LDL i HDL subfrakcija kod 181 pacijenta sa KAB i 178 zdravih osoba. LDL i HDL subfrakcije su razdvojene metodom vertikalne elektroforeze na gradijentu poliakrilamida, a koncentracije lipidnih parametara su određene rutinskim laboratorijskim metodama. Utvrdili smo da KAB pacijenti imaju značajno manje dijametre LDL i HDL čestica (P lt 0,001), veći udeo LDL III, a manje HDL 2b subfrakcija (P lt 0,05). U KAB grupi povišena koncentracija TG bila je u korelaciji sa manjim LDL i HDL dijametrima i nižim udelom LDL I subfrakcija. Pacijenti sa hipertrigliceridemijom imali su manje LDL dijametre (P lt 0,01) i veći udeo malih, gustih LDL čestica (P lt 0,05) u odnosu na normotrigliceridemične pacijente. Sem toga, kod pacijenata sa hipertrigliceridemijom uočena je preraspodela HDL subfrakcija ka manjim česticama. Naši rezultati ukazuju da je koncentracija TG u serumu glavni lipidni faktor rizika koji determiniše količinu malih, gustih LDL i HDL čestica u KAB.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Influence of hypertrigliceridemia on small, dense LDL and HDL particles in coronary artery disease, Uticaj hipertrigliceridemije na male, guste LDL i HDL čestice u koronarnoj arterijskoj bolesti",
volume = "62",
number = "5",
pages = "461-474",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1783"
}

Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Bogavac-Stanojević, N., Spasić, S.,& Kalimanovska-Oštrić, D.. (2012). Influence of hypertrigliceridemia on small, dense LDL and HDL particles in coronary artery disease. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 62(5), 461-474.
https://hdl.handle.net/21.15107/rcub_farfar_1783

Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Bogavac-Stanojević N, Spasić S, Kalimanovska-Oštrić D. Influence of hypertrigliceridemia on small, dense LDL and HDL particles in coronary artery disease. in Arhiv za farmaciju. 2012;62(5):461-474.
https://hdl.handle.net/21.15107/rcub_farfar_1783 .

Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Bogavac-Stanojević, Nataša, Spasić, Slavica, Kalimanovska-Oštrić, Dimitra, "Influence of hypertrigliceridemia on small, dense LDL and HDL particles in coronary artery disease" in Arhiv za farmaciju, 62, no. 5 (2012):461-474,
https://hdl.handle.net/21.15107/rcub_farfar_1783 .

TY  - CONF
AU  - Dopsaj, Violeta
AU  - Miković-Golubović, Gordana
AU  - Martinović, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1751
PB  - Wiley-Blackwell, Malden
C3  - International Journal of Laboratory Hematology
T1  - Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease
VL  - 34
SP  - 112
EP  - 112
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1751
ER  - 

@conference{
author = "Dopsaj, Violeta and Miković-Golubović, Gordana and Martinović, Jelena and Kalimanovska-Oštrić, Dimitra",
year = "2012",
publisher = "Wiley-Blackwell, Malden",
journal = "International Journal of Laboratory Hematology",
title = "Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease",
volume = "34",
pages = "112-112",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1751"
}

Dopsaj, V., Miković-Golubović, G., Martinović, J.,& Kalimanovska-Oštrić, D.. (2012). Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease. in International Journal of Laboratory Hematology
Wiley-Blackwell, Malden., 34, 112-112.
https://hdl.handle.net/21.15107/rcub_farfar_1751

Dopsaj V, Miković-Golubović G, Martinović J, Kalimanovska-Oštrić D. Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease. in International Journal of Laboratory Hematology. 2012;34:112-112.
https://hdl.handle.net/21.15107/rcub_farfar_1751 .

Dopsaj, Violeta, Miković-Golubović, Gordana, Martinović, Jelena, Kalimanovska-Oštrić, Dimitra, "Evaluation of derived coulter red blood cell parameters for the assesment of iron deficiency in adults with congenital heart disease" in International Journal of Laboratory Hematology, 34 (2012):112-112,
https://hdl.handle.net/21.15107/rcub_farfar_1751 .

TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Miković-Golubović, Gordana
AU  - Martinović, Jelena
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1672
AB  - Introduction: The aim of our study was to evaluate derived red blood cell parameters in determining the presence of iron depletion and iron-deficient erythropoiesis, as states that precede iron deficiency anemia, in adults with congenital heart disease. Methods: Eighty-eight adults who were diagnosed with congenital heart disease were divided into two groups (cyanotic and acyanotic). In both groups, congenital heart disease patients were then divided into three subgroups: with iron depletion, with iron-deficient erythropoiesis, and a control group. The following parameters were measured: complete blood count, reticulocytes, ferritin, soluble transferrin receptor, haptoglobin, lactate dehydrogenase, and calculated parameters: low hemoglobin density (LHD), red cell size factor (RSF), and microcytic anemia factor (MAF). Results: Discriminant analysis indicated statistically significant differences in the first discriminant function: Function 1 body iron, LHD, MAF, sTfR, and RSF (P  lt  0.001) in patients with acyanotic congenital heart disease and significant differences in both discriminant functions in patients with cyanotic congenital heart disease: Function 1 body iron, soluble transferrin receptor, LHD, RSF, MAF, lactate dehydrogenase, and haptoglobin (P = 0.008) and Function 2 reticulocytes (#), immature reticulocyte fraction and reticulocytes (%) (P = 0.049). Conclusions: Beside parameters that describe iron metabolism dynamics (body iron and soluble transferrin receptor), LHD, indicator of hypochromia, have the highest potential to differentiate and classify iron deficiency in patients with congenital heart disease.
PB  - Wiley-Blackwell, Hoboken
T2  - International Journal of Laboratory Hematology
T1  - Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease
VL  - 34
IS  - 5
SP  - 461
EP  - 472
DO  - 10.1111/j.1751-553X.2012.01417.x
ER  - 

@article{
author = "Dopsaj, Violeta and Miković-Golubović, Gordana and Martinović, Jelena and Kalimanovska-Oštrić, Dimitra",
year = "2012",
abstract = "Introduction: The aim of our study was to evaluate derived red blood cell parameters in determining the presence of iron depletion and iron-deficient erythropoiesis, as states that precede iron deficiency anemia, in adults with congenital heart disease. Methods: Eighty-eight adults who were diagnosed with congenital heart disease were divided into two groups (cyanotic and acyanotic). In both groups, congenital heart disease patients were then divided into three subgroups: with iron depletion, with iron-deficient erythropoiesis, and a control group. The following parameters were measured: complete blood count, reticulocytes, ferritin, soluble transferrin receptor, haptoglobin, lactate dehydrogenase, and calculated parameters: low hemoglobin density (LHD), red cell size factor (RSF), and microcytic anemia factor (MAF). Results: Discriminant analysis indicated statistically significant differences in the first discriminant function: Function 1 body iron, LHD, MAF, sTfR, and RSF (P  lt  0.001) in patients with acyanotic congenital heart disease and significant differences in both discriminant functions in patients with cyanotic congenital heart disease: Function 1 body iron, soluble transferrin receptor, LHD, RSF, MAF, lactate dehydrogenase, and haptoglobin (P = 0.008) and Function 2 reticulocytes (#), immature reticulocyte fraction and reticulocytes (%) (P = 0.049). Conclusions: Beside parameters that describe iron metabolism dynamics (body iron and soluble transferrin receptor), LHD, indicator of hypochromia, have the highest potential to differentiate and classify iron deficiency in patients with congenital heart disease.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Laboratory Hematology",
title = "Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease",
volume = "34",
number = "5",
pages = "461-472",
doi = "10.1111/j.1751-553X.2012.01417.x"
}

Dopsaj, V., Miković-Golubović, G., Martinović, J.,& Kalimanovska-Oštrić, D.. (2012). Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease. in International Journal of Laboratory Hematology
Wiley-Blackwell, Hoboken., 34(5), 461-472.
https://doi.org/10.1111/j.1751-553X.2012.01417.x

Dopsaj V, Miković-Golubović G, Martinović J, Kalimanovska-Oštrić D. Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease. in International Journal of Laboratory Hematology. 2012;34(5):461-472.
doi:10.1111/j.1751-553X.2012.01417.x .

Dopsaj, Violeta, Miković-Golubović, Gordana, Martinović, Jelena, Kalimanovska-Oštrić, Dimitra, "Evaluation of derived Coulter red blood cell parameters for the assessment of iron deficiency in adults with congenital heart disease" in International Journal of Laboratory Hematology, 34, no. 5 (2012):461-472,
https://doi.org/10.1111/j.1751-553X.2012.01417.x . .

TY  - CONF
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Spasić, S.
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Kotur-Stevuljević, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1410
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Relation between iron status parameters and other cardiovascular risk factors extracted by factor analysis in patients with coronary artery disease
VL  - 11
IS  - 2
SP  - 46
EP  - 46
DO  - 10.1016/S1567-5688(10)70208-7
ER  - 

@conference{
author = "Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Spasić, S. and Kalimanovska-Oštrić, Dimitra and Kotur-Stevuljević, Jelena and Jelić-Ivanović, Zorana",
year = "2010",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Relation between iron status parameters and other cardiovascular risk factors extracted by factor analysis in patients with coronary artery disease",
volume = "11",
number = "2",
pages = "46-46",
doi = "10.1016/S1567-5688(10)70208-7"
}

Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Spasić, S., Kalimanovska-Oštrić, D., Kotur-Stevuljević, J.,& Jelić-Ivanović, Z.. (2010). Relation between iron status parameters and other cardiovascular risk factors extracted by factor analysis in patients with coronary artery disease. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 11(2), 46-46.
https://doi.org/10.1016/S1567-5688(10)70208-7

Spasojević-Kalimanovska V, Bogavac-Stanojević N, Spasić S, Kalimanovska-Oštrić D, Kotur-Stevuljević J, Jelić-Ivanović Z. Relation between iron status parameters and other cardiovascular risk factors extracted by factor analysis in patients with coronary artery disease. in Atherosclerosis Supplements. 2010;11(2):46-46.
doi:10.1016/S1567-5688(10)70208-7 .

Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Spasić, S., Kalimanovska-Oštrić, Dimitra, Kotur-Stevuljević, Jelena, Jelić-Ivanović, Zorana, "Relation between iron status parameters and other cardiovascular risk factors extracted by factor analysis in patients with coronary artery disease" in Atherosclerosis Supplements, 11, no. 2 (2010):46-46,
https://doi.org/10.1016/S1567-5688(10)70208-7 . .

TY  - CONF
AU  - Spasojević-Kalimanovska, Vesna
AU  - Veljić, Sandra
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Memon, Lidija
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1396
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease
VL  - 11
IS  - 2
SP  - 161
EP  - 161
DO  - 10.1016/S1567-5688(10)70756-X
ER  - 

@conference{
author = "Spasojević-Kalimanovska, Vesna and Veljić, Sandra and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Memon, Lidija and Kalimanovska-Oštrić, Dimitra",
year = "2010",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease",
volume = "11",
number = "2",
pages = "161-161",
doi = "10.1016/S1567-5688(10)70756-X"
}

Spasojević-Kalimanovska, V., Veljić, S., Kotur-Stevuljević, J., Bogavac-Stanojević, N., Memon, L.,& Kalimanovska-Oštrić, D.. (2010). C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 11(2), 161-161.
https://doi.org/10.1016/S1567-5688(10)70756-X

Spasojević-Kalimanovska V, Veljić S, Kotur-Stevuljević J, Bogavac-Stanojević N, Memon L, Kalimanovska-Oštrić D. C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease. in Atherosclerosis Supplements. 2010;11(2):161-161.
doi:10.1016/S1567-5688(10)70756-X .

Spasojević-Kalimanovska, Vesna, Veljić, Sandra, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Memon, Lidija, Kalimanovska-Oštrić, Dimitra, "C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease" in Atherosclerosis Supplements, 11, no. 2 (2010):161-161,
https://doi.org/10.1016/S1567-5688(10)70756-X . .

TY  - CONF
AU  - Jelić-Ivanović, Zorana
AU  - Bogavac-Stanojević, Nataša
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, S.
AU  - Memon, Lidija
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1057
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development
VL  - 9
IS  - 1
SP  - 107
EP  - 107
DO  - 10.1016/S1567-5688(08)70428-8
ER  - 

@conference{
author = "Jelić-Ivanović, Zorana and Bogavac-Stanojević, Nataša and Spasojević-Kalimanovska, Vesna and Spasić, S. and Memon, Lidija and Kalimanovska-Oštrić, Dimitra",
year = "2008",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development",
volume = "9",
number = "1",
pages = "107-107",
doi = "10.1016/S1567-5688(08)70428-8"
}

Jelić-Ivanović, Z., Bogavac-Stanojević, N., Spasojević-Kalimanovska, V., Spasić, S., Memon, L.,& Kalimanovska-Oštrić, D.. (2008). Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 9(1), 107-107.
https://doi.org/10.1016/S1567-5688(08)70428-8

Jelić-Ivanović Z, Bogavac-Stanojević N, Spasojević-Kalimanovska V, Spasić S, Memon L, Kalimanovska-Oštrić D. Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development. in Atherosclerosis Supplements. 2008;9(1):107-107.
doi:10.1016/S1567-5688(08)70428-8 .

Jelić-Ivanović, Zorana, Bogavac-Stanojević, Nataša, Spasojević-Kalimanovska, Vesna, Spasić, S., Memon, Lidija, Kalimanovska-Oštrić, Dimitra, "Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development" in Atherosclerosis Supplements, 9, no. 1 (2008):107-107,
https://doi.org/10.1016/S1567-5688(08)70428-8 . .

TY  - CONF
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, S.
AU  - Jelić-Ivanović, Zorana
AU  - Bogavac-Stanojević, Nataša
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1047
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Association of increased ferritin with angiographically verified coronary artery disease
VL  - 9
IS  - 1
SP  - 234
EP  - 234
DO  - 10.1016/S1567-5688(08)70936-X
ER  - 

@conference{
author = "Spasojević-Kalimanovska, Vesna and Spasić, S. and Jelić-Ivanović, Zorana and Bogavac-Stanojević, Nataša and Kalimanovska-Oštrić, Dimitra",
year = "2008",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Association of increased ferritin with angiographically verified coronary artery disease",
volume = "9",
number = "1",
pages = "234-234",
doi = "10.1016/S1567-5688(08)70936-X"
}

Spasojević-Kalimanovska, V., Spasić, S., Jelić-Ivanović, Z., Bogavac-Stanojević, N.,& Kalimanovska-Oštrić, D.. (2008). Association of increased ferritin with angiographically verified coronary artery disease. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 9(1), 234-234.
https://doi.org/10.1016/S1567-5688(08)70936-X

Spasojević-Kalimanovska V, Spasić S, Jelić-Ivanović Z, Bogavac-Stanojević N, Kalimanovska-Oštrić D. Association of increased ferritin with angiographically verified coronary artery disease. in Atherosclerosis Supplements. 2008;9(1):234-234.
doi:10.1016/S1567-5688(08)70936-X .

Spasojević-Kalimanovska, Vesna, Spasić, S., Jelić-Ivanović, Zorana, Bogavac-Stanojević, Nataša, Kalimanovska-Oštrić, Dimitra, "Association of increased ferritin with angiographically verified coronary artery disease" in Atherosclerosis Supplements, 9, no. 1 (2008):234-234,
https://doi.org/10.1016/S1567-5688(08)70936-X . .

TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Stefanović, Aleksandra
AU  - Vujović, Ana
AU  - Memon, Lidija
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1119
AB  - Objectives: High-density lipoprotein (HDL) associated paraoxonase. 1 (PON1) is an essential component of HDLs' capability to protect low-density lipoproteins (LDL) from oxidative modification and thus to limit the atherosclerotic process. The aim of the Current Study was to investigate the association between oxidative stress status, indices of inflammation and PON1 status parameters. Design and methods: We determined the relationship between the oxidative stress status, inflammatory markers and PON1 status parameters in 261 middle-aged subjects: 156 coronary heart disease (CHD) patients and 105 CHD-free subjects (as the control group). The PON1 status involved PON1 activity measurements towards two substrates: paraoxon (POase activity) and diazoxon (DZOase activity) and subsequent PON1(Q192R) activity phenotype determination. Results: A statistically significant greater malondialdehyde (MDA) concentration in the RR phenotype subjects compared to QQ subjects within the CHD group was apparent (P lt 0.05). Multiple linear regression analysis revealed an independent influence of plasmatic SOD activity (P lt 0.05) on POase values and MDA (P lt 0.01) and O-2(center dot-) (P lt 0.05) on DZOase values. Involvement of inflammatory markers (fibrinogen and hsCRP) in the regression model did not hinder the influence of SOD and MDA on POase and DZOase activities, respectively. Conclusions: Our CHD patients were in a state of oxidative stress, which was most evident in the RR phenotype group. The QQ phenotype group is associated with the lowest oxidative stress status level and also with a better capacity for anti-oxidative protection. Oxidative stress in CHD patients is maintained by systemic low-grade inflammation which results in PON1 enzymatic activity exhaustion. Therefore, deeper investigation of an effective anti-oxidative and anti-inflammatory therapy should be necessary in order to increase anti-oxidative potency and improve PON1 status of CHD patients.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients
VL  - 41
IS  - 13
SP  - 1067
EP  - 1073
DO  - 10.1016/j.clinbiochem.2008.06.009
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Spasić, Slavica and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Stefanović, Aleksandra and Vujović, Ana and Memon, Lidija and Kalimanovska-Oštrić, Dimitra",
year = "2008",
abstract = "Objectives: High-density lipoprotein (HDL) associated paraoxonase. 1 (PON1) is an essential component of HDLs' capability to protect low-density lipoproteins (LDL) from oxidative modification and thus to limit the atherosclerotic process. The aim of the Current Study was to investigate the association between oxidative stress status, indices of inflammation and PON1 status parameters. Design and methods: We determined the relationship between the oxidative stress status, inflammatory markers and PON1 status parameters in 261 middle-aged subjects: 156 coronary heart disease (CHD) patients and 105 CHD-free subjects (as the control group). The PON1 status involved PON1 activity measurements towards two substrates: paraoxon (POase activity) and diazoxon (DZOase activity) and subsequent PON1(Q192R) activity phenotype determination. Results: A statistically significant greater malondialdehyde (MDA) concentration in the RR phenotype subjects compared to QQ subjects within the CHD group was apparent (P lt 0.05). Multiple linear regression analysis revealed an independent influence of plasmatic SOD activity (P lt 0.05) on POase values and MDA (P lt 0.01) and O-2(center dot-) (P lt 0.05) on DZOase values. Involvement of inflammatory markers (fibrinogen and hsCRP) in the regression model did not hinder the influence of SOD and MDA on POase and DZOase activities, respectively. Conclusions: Our CHD patients were in a state of oxidative stress, which was most evident in the RR phenotype group. The QQ phenotype group is associated with the lowest oxidative stress status level and also with a better capacity for anti-oxidative protection. Oxidative stress in CHD patients is maintained by systemic low-grade inflammation which results in PON1 enzymatic activity exhaustion. Therefore, deeper investigation of an effective anti-oxidative and anti-inflammatory therapy should be necessary in order to increase anti-oxidative potency and improve PON1 status of CHD patients.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients",
volume = "41",
number = "13",
pages = "1067-1073",
doi = "10.1016/j.clinbiochem.2008.06.009"
}

Kotur-Stevuljević, J., Spasić, S., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Stefanović, A., Vujović, A., Memon, L.,& Kalimanovska-Oštrić, D.. (2008). PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 41(13), 1067-1073.
https://doi.org/10.1016/j.clinbiochem.2008.06.009

Kotur-Stevuljević J, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Stefanović A, Vujović A, Memon L, Kalimanovska-Oštrić D. PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients. in Clinical Biochemistry. 2008;41(13):1067-1073.
doi:10.1016/j.clinbiochem.2008.06.009 .

Kotur-Stevuljević, Jelena, Spasić, Slavica, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Stefanović, Aleksandra, Vujović, Ana, Memon, Lidija, Kalimanovska-Oštrić, Dimitra, "PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients" in Clinical Biochemistry, 41, no. 13 (2008):1067-1073,
https://doi.org/10.1016/j.clinbiochem.2008.06.009 . .