TY  - JOUR
AU  - Aleksić, Mara
AU  - Lijeskić, Nikola
AU  - Pantić, Jelena
AU  - Kapetanović, Vera
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2009
AB  - The voltammetric behavior of three cephalosporins: ceftazidime, cefuroxime-axetil and ceftriaxone has been examined in pH range 2.0-8.0 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), using a hanging mercury drop electrode (HMDE). The effect of pH of the electrolyte solution and scan rate on the peak currents and peak potentials was examined. The nature of the electrode reduction process in acid solution was found to be diffusion controlled for ceftazidime and cefuroxime-axetil, but strongly influenced by adsorption in the case of ceftriaxone reduction. The adsorption and reorientation of the ceftriaxone molecule at the electrode surface caused instability of the voltammetric signal and disabled its determination in the acid medium. Ceftriaxone adsorption decreased with the increase of pH, and at pH>7 the reduction process became diffusion controlled. Based on this study, DPV method was developed, validated and suggested for determination of ceftazidime at pH 2.0, cefuroxime-axetil at pH 3.5 and for ceftriaxone at pH 8.0. Linear concentration ranges, limits of detection (LOD) and quantification (LOQ) were determined. The method was applied for determination of cephalosporins in pharmaceutical dosage forms: Ceftazidime powder, Ceroxim tablets and Longaceph powder for injection solution.
AB  - Voltametrijsko ponašanje tri cephalosporina: ceftazidima, cefuroksim-aksetila i ceftriaksona ispitivano je cikličnom (CV) i diferencijalno pulsnom (DPV) voltametrijom u pH oblasti od 2,0 do 8,0 na visećoj živnoj kapi. Razmatrani su uticaji pH osnovnog elektrolita i brzine promene potencijala na vrednost stuje i potencijala voltametrijskih pikova. Rezultati dobijeni u kiseloj sredini su pokazali da je redukcija ceftazidima i cefuroksim-aksetila difuziono kontrolisan proces, a da je u slučaju ceftriaksona priroda redukcije na elektrodi jako zavisna od adsorpcije. Posledica adsorpcije i reorijentacije molekula ceftriaksona na površini elektrode je nestabilnost i nereproduktivnost voltametrijskog signala što onemogućava određivanje cefriaksona u kiseloj sredini. Intenzitet adsorpcije ceftriaksona opada sa porastom pH i pri pH>7 njegova redukcija postaje difuzijom kontrolisan proces. Na osnovu ovih rezultata predložena je i validirana DPV metoda za određvanje ceftazidima na pH 2,0, cefuroksim-aksetila na pH 3,5 i ceftriaksona na pH 8,0. Određene su vrednosti opsega linearnosti, granice detekcije i određivanja. Metoda je uspešno primenjena za određivanje ovih cefalosporina u farmaceutskim doziranim oblicima i to u Ceroxim tabletama i Ceftazidim i Longaceph prašku za injekcione rastvore.
PB  - Univerzitet u Nišu, Niš
T2  - Facta universitatis - series: Physics, Chemistry and Technology
T1  - Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone
T1  - Elektrohemijsko ponašanje i primena diferencijalno pulsne voltametrije za određivanje ceftazidima, cefuroksim-aksetila i ceftriaksona
VL  - 11
IS  - 1
SP  - 55
EP  - 66
DO  - 10.2298/FUPCT1301055A
ER  - 

@article{
author = "Aleksić, Mara and Lijeskić, Nikola and Pantić, Jelena and Kapetanović, Vera",
year = "2013",
abstract = "The voltammetric behavior of three cephalosporins: ceftazidime, cefuroxime-axetil and ceftriaxone has been examined in pH range 2.0-8.0 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), using a hanging mercury drop electrode (HMDE). The effect of pH of the electrolyte solution and scan rate on the peak currents and peak potentials was examined. The nature of the electrode reduction process in acid solution was found to be diffusion controlled for ceftazidime and cefuroxime-axetil, but strongly influenced by adsorption in the case of ceftriaxone reduction. The adsorption and reorientation of the ceftriaxone molecule at the electrode surface caused instability of the voltammetric signal and disabled its determination in the acid medium. Ceftriaxone adsorption decreased with the increase of pH, and at pH>7 the reduction process became diffusion controlled. Based on this study, DPV method was developed, validated and suggested for determination of ceftazidime at pH 2.0, cefuroxime-axetil at pH 3.5 and for ceftriaxone at pH 8.0. Linear concentration ranges, limits of detection (LOD) and quantification (LOQ) were determined. The method was applied for determination of cephalosporins in pharmaceutical dosage forms: Ceftazidime powder, Ceroxim tablets and Longaceph powder for injection solution., Voltametrijsko ponašanje tri cephalosporina: ceftazidima, cefuroksim-aksetila i ceftriaksona ispitivano je cikličnom (CV) i diferencijalno pulsnom (DPV) voltametrijom u pH oblasti od 2,0 do 8,0 na visećoj živnoj kapi. Razmatrani su uticaji pH osnovnog elektrolita i brzine promene potencijala na vrednost stuje i potencijala voltametrijskih pikova. Rezultati dobijeni u kiseloj sredini su pokazali da je redukcija ceftazidima i cefuroksim-aksetila difuziono kontrolisan proces, a da je u slučaju ceftriaksona priroda redukcije na elektrodi jako zavisna od adsorpcije. Posledica adsorpcije i reorijentacije molekula ceftriaksona na površini elektrode je nestabilnost i nereproduktivnost voltametrijskog signala što onemogućava određivanje cefriaksona u kiseloj sredini. Intenzitet adsorpcije ceftriaksona opada sa porastom pH i pri pH>7 njegova redukcija postaje difuzijom kontrolisan proces. Na osnovu ovih rezultata predložena je i validirana DPV metoda za određvanje ceftazidima na pH 2,0, cefuroksim-aksetila na pH 3,5 i ceftriaksona na pH 8,0. Određene su vrednosti opsega linearnosti, granice detekcije i određivanja. Metoda je uspešno primenjena za određivanje ovih cefalosporina u farmaceutskim doziranim oblicima i to u Ceroxim tabletama i Ceftazidim i Longaceph prašku za injekcione rastvore.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Physics, Chemistry and Technology",
title = "Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone, Elektrohemijsko ponašanje i primena diferencijalno pulsne voltametrije za određivanje ceftazidima, cefuroksim-aksetila i ceftriaksona",
volume = "11",
number = "1",
pages = "55-66",
doi = "10.2298/FUPCT1301055A"
}

Aleksić, M., Lijeskić, N., Pantić, J.,& Kapetanović, V.. (2013). Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone. in Facta universitatis - series: Physics, Chemistry and Technology
Univerzitet u Nišu, Niš., 11(1), 55-66.
https://doi.org/10.2298/FUPCT1301055A

Aleksić M, Lijeskić N, Pantić J, Kapetanović V. Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone. in Facta universitatis - series: Physics, Chemistry and Technology. 2013;11(1):55-66.
doi:10.2298/FUPCT1301055A .

Aleksić, Mara, Lijeskić, Nikola, Pantić, Jelena, Kapetanović, Vera, "Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone" in Facta universitatis - series: Physics, Chemistry and Technology, 11, no. 1 (2013):55-66,
https://doi.org/10.2298/FUPCT1301055A . .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Radulović, Valentina
AU  - Lijeskić, Nikola
AU  - Kapetanović, Vera
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1739
AB  - The electrochemical study of varenicline (VAR) was done in a wide pH range (2-12), at boron doped diamond electrode (BDDE), glassy carbon electrode (GCE) and hanging mercury electrode (HMDE), using cyclic (CV), square wave (SW) and adsorptive stripping square wave (AdSSW) voltammetric techniques. Depending on the pH and the type of the working electrode the characteristic electrochemical behavior of varenicline was established. The mechanism of the reduction process was suggested. Based on the obtained results, the new electroanalytical method was developed for its determination in the buffer solutions and plasma samples. By applying a square wave voltammetry (SWV) on BDDE and GCE, at pH 3.5 and 4.0, the linear dependence in plasma samples was achieved within the concentration range from 2 10(-6) -1 x 10(-5) M and 4 x 10(-6) -1 x 10(-5) M, respectively. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 7.1 x 10(-7) M and 2.4 x 10(-6) M on BDDE, and 1.0 x 10(-6) M and 3.5 x 10(-6) M on GCE, respectively. The recovery and RSD values obtained for VAR in plasma suggested BDDE electrode to be preferable in comparison with GCE. The accuracy of the voltammetric method was confirmed by the determination of VAR in plasma spiked with Champix (R) tablets and the results were statistically compared with those obtained with Ultra Performance Liquid Chromatography (UPLC) method, as a reference one.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Analytical Chemistry
T1  - Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes
VL  - 8
IS  - 1
SP  - 133
EP  - 142
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1739
ER  - 

@article{
author = "Aleksić, Mara and Radulović, Valentina and Lijeskić, Nikola and Kapetanović, Vera",
year = "2012",
abstract = "The electrochemical study of varenicline (VAR) was done in a wide pH range (2-12), at boron doped diamond electrode (BDDE), glassy carbon electrode (GCE) and hanging mercury electrode (HMDE), using cyclic (CV), square wave (SW) and adsorptive stripping square wave (AdSSW) voltammetric techniques. Depending on the pH and the type of the working electrode the characteristic electrochemical behavior of varenicline was established. The mechanism of the reduction process was suggested. Based on the obtained results, the new electroanalytical method was developed for its determination in the buffer solutions and plasma samples. By applying a square wave voltammetry (SWV) on BDDE and GCE, at pH 3.5 and 4.0, the linear dependence in plasma samples was achieved within the concentration range from 2 10(-6) -1 x 10(-5) M and 4 x 10(-6) -1 x 10(-5) M, respectively. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 7.1 x 10(-7) M and 2.4 x 10(-6) M on BDDE, and 1.0 x 10(-6) M and 3.5 x 10(-6) M on GCE, respectively. The recovery and RSD values obtained for VAR in plasma suggested BDDE electrode to be preferable in comparison with GCE. The accuracy of the voltammetric method was confirmed by the determination of VAR in plasma spiked with Champix (R) tablets and the results were statistically compared with those obtained with Ultra Performance Liquid Chromatography (UPLC) method, as a reference one.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Analytical Chemistry",
title = "Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes",
volume = "8",
number = "1",
pages = "133-142",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1739"
}

Aleksić, M., Radulović, V., Lijeskić, N.,& Kapetanović, V.. (2012). Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes. in Current Analytical Chemistry
Bentham Science Publ Ltd, Sharjah., 8(1), 133-142.
https://hdl.handle.net/21.15107/rcub_farfar_1739

Aleksić M, Radulović V, Lijeskić N, Kapetanović V. Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes. in Current Analytical Chemistry. 2012;8(1):133-142.
https://hdl.handle.net/21.15107/rcub_farfar_1739 .

Aleksić, Mara, Radulović, Valentina, Lijeskić, Nikola, Kapetanović, Vera, "Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes" in Current Analytical Chemistry, 8, no. 1 (2012):133-142,
https://hdl.handle.net/21.15107/rcub_farfar_1739 .