@article{
author = "Pejić, Nataša and Anić, Slobodan and Mijatović, Miroslav and Milenković, Svetozar and Ćirić, Jasna and Grozdić, Tomislav D.",
year = "2003",
abstract = "The results of investigation of a new kinetic analytical method for microquantitative (microconcentration/microvolume) determination of morphine is given. This method is based on potentiometric monitoring of the concentration perturbations of the Bray-Liebhafsky reaction as the oscillatory reaction system being in a stable non-equilibrium stationary state close to a bifurcation point. The experiments are carried out in an open reactor at T=310 K. The response of the matrix system to perturbations by different concentrations of morphine ethanolic solutions is followed by a Pt-electrode. In the concentration range from 0.11 to 2.90 μg mL-1 (3.14´10-7 - 7.65´10-6 mol dm-3) of morphine, a linear response of the maximal potential shift versus the logarithm concentrations of morphine is found. The average relative standard deviation of morphine determination in 5% ethanol solution is 5,4%. The detection limit of the morphine concentration is 41 ng mL-1. The accuracy of the method is 98.5%. The method is simple, reliable and cheap., Daju se rezultati istraživanja nove kinetičke metode mikrozapreminskog/mikrokoncentracionog određivanja morfina. Ona se zasniva na potenciometrijskom praćenju odgovora analitičke matrice - nelinearnog reakcionog sistema Bray-Liebhafsky u neravnotežnom stacionarnom stanju u blizini bifurkacione tačke na impulsne perturbacije različitim količinama alkoholnog rastvora alkaloida morfina. U uslovima korišćene izotermalne (T=310 K) analitičke matrice, koja je realizovana u protočnom dobromešajućem reaktoru, promena potencijala Pt-oksidoredukcione elektrode izazvana perturbacijom sa morfinom u odnosu na potencijal koji karakteriše neravnotežno stacionarno stanje neperturbovane analitičke matrice, pokazuje linearnu zavisnost od logaritma količine morfina u području od 0,11-2,90 μg mL-1 (3,14x10-7 do 7,65x10-6 mol dm-3) morfina. Pri tome je srednja relativna standardna devijacija određivanja morfina u 5% alkoholnom rastvoru 5,4%, detekcioni limit 41 ng mL-1, a tačnost 98,5%. Metoda je jednostavna pouzdana i jeftina.",
publisher = "Institut bezbednosti, Beograd",
journal = "Nauka, tehnika, bezbednost",
title = "Contribution to development of new microvolume/microconcentration quantitative analyze: Determination of morphine, Doprinos razvoju nove mikrozapreminske/mikro-koncentracione kvantitativne analize - određivanje morfina",
volume = "13",
number = "1",
pages = "67-74",
url = "https://hdl.handle.net/21.15107/rcub_farfar_467"
}