TY  - JOUR
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Milenković, Milan
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukomanović, Predrag
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3996
AB  - The aim of this study was to explore the mechanisms of bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) mixture-induced asthma development and test probiotic as a potential positive intervention. Comparative Toxicogenomics Database (CTD) and ToppGene Suite were used as the main tools for in silico analysis. In vivo 28-day experiment was conducted on rats - seven groups (n = 6): (1) Control: corn oil, (2) P: probiotic (8.78 * 108 CFU/kg/day); (3) DEHP: 50 mg/kg b.w./day, (4) DBP: 50 mg/kg b.w./day, (5) BPA: 25 mg/kg b.w./day; (6) MIX: DEHP + DBP + BPA; (7) MIX + P. Lungs, thymus and kidneys were extracted and prepared for redox status and essential metals analysis. By conducting additional in vitro experiment, probiotic phthalate and BPA binding ability was explored. There were 24 DEHP, DBP and BPA asthma-related genes, indicating the three most probable mechanisms - apoptosis, inflammation and oxidative stress. In vivo experiment confirmed that significant changes in redox status/essential metal parameters were either prominent, or only present in the MIX group, indicating possible additive effects. In vitro experiment confirmed the ability of the multy-strain probiotic to bind DEHP/DBP/BPA mixture, while probiotic administration ameliorated mixtureinduced changes in rat tissue.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention
VL  - 158
DO  - 10.1016/j.fct.2021.112671
ER  - 

@article{
author = "Baralić, Katarina and Božić, Dragica and Živančević, Katarina and Milenković, Milan and Javorac, Dragana and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukomanović, Predrag and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2021",
abstract = "The aim of this study was to explore the mechanisms of bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) mixture-induced asthma development and test probiotic as a potential positive intervention. Comparative Toxicogenomics Database (CTD) and ToppGene Suite were used as the main tools for in silico analysis. In vivo 28-day experiment was conducted on rats - seven groups (n = 6): (1) Control: corn oil, (2) P: probiotic (8.78 * 108 CFU/kg/day); (3) DEHP: 50 mg/kg b.w./day, (4) DBP: 50 mg/kg b.w./day, (5) BPA: 25 mg/kg b.w./day; (6) MIX: DEHP + DBP + BPA; (7) MIX + P. Lungs, thymus and kidneys were extracted and prepared for redox status and essential metals analysis. By conducting additional in vitro experiment, probiotic phthalate and BPA binding ability was explored. There were 24 DEHP, DBP and BPA asthma-related genes, indicating the three most probable mechanisms - apoptosis, inflammation and oxidative stress. In vivo experiment confirmed that significant changes in redox status/essential metal parameters were either prominent, or only present in the MIX group, indicating possible additive effects. In vitro experiment confirmed the ability of the multy-strain probiotic to bind DEHP/DBP/BPA mixture, while probiotic administration ameliorated mixtureinduced changes in rat tissue.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention",
volume = "158",
doi = "10.1016/j.fct.2021.112671"
}

Baralić, K., Božić, D., Živančević, K., Milenković, M., Javorac, D., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukomanović, P., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2021). Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention. in Food and Chemical Toxicology
Elsevier Ltd., 158.
https://doi.org/10.1016/j.fct.2021.112671

Baralić K, Božić D, Živančević K, Milenković M, Javorac D, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Vukomanović P, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention. in Food and Chemical Toxicology. 2021;158.
doi:10.1016/j.fct.2021.112671 .

Baralić, Katarina, Božić, Dragica, Živančević, Katarina, Milenković, Milan, Javorac, Dragana, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukomanović, Predrag, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Integrating in silico with in vivo approach to investigate phthalate and
bisphenol A mixture-linked asthma development: Positive
probiotic intervention" in Food and Chemical Toxicology, 158 (2021),
https://doi.org/10.1016/j.fct.2021.112671 . .

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha, Aleksandra
AU  - Vukomanović, Predrag
AU  - Matović, Vesna
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2761
AB  - Human immunodeficiency virus (HIV), isolated in 1983 by Paster Institute researches, has been recognised as the cause of million fatalies in 21st century. Initial monotherapy failed to show promising results, however, with the development of highly active antiretroviral therapy new era of HIV treatment has started. This new approach resulted in extended life time, reduced development of virus resistance as well as morbidity and mortality of HIV patients. Antiretroviral therapy is longlife and connected with serious adverse and toxic effects. Mitochondrial toxicity can be manifested as periferal lipoathrophy, hepatic steatosis, lactic acidosis, neuropathy and miopathy. Metabolic features associated with lipodystrophy include hypertriglyceridaemia, hypercholesterolaemia, insuline resistance and abnormal glucose tolerance. Hepatotoxicity, nephrotoxicity, osteopenia, rash and gastrointestinal symptoms can also occur during antiretroviral therapy. The aim od this work was to present the most important adverse and toxic effects of drugs used in HIV therapy.
AB  - Virus humane imunodeficijencije, izolovan zahvaljujući istraživačima Paster Instituta 1983. godine, uzročnik je milionskih žrtava u XXI veku. Kako inicijalna monoterapija nije uspela da pokaže zavidne rezultate, razvojem visoko aktivne antiretrovirusne terapije započeta je nova era HIV terapije. Nov pristup lečenju produžio je životni vek obolelih, smanjio pojavu rezistencija kao i stopu morbiditeta i mortaliteta obolelih. Antiretrovirusna terapija je doživotna i nosi sa sobom ozbiljne neželjene i toksične efekte. Mitohondrijska toksičnost može se ispoljiti kao periferna lipoatrofija, hepatična steatoza, laktična acidoza, neuropatija i miopatija. Metabolički poremaćaji udruženi sa lipodistrofijom uključuju hipertrigliceridemiju, hiperholestirolemiju, insulinsku rezistenciju i abnormalnu glukoznu toleranciju. Hepatotoksičnost, nefrotoksičnost, ostepenija, pojava raša i smetnje na nivou gastroinestinalnog trakta takođe se mogu javiti pri primeni antiretrovirusne terapije. Cilj ovoga rada je bio da da prikaz najznačajnijih neželjenih i toksičnih efekata lekova koji se koriste u terapiji HIV-a.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Safety of antiretroviral drugs
T1  - Bezbednost primene lekova koji se koriste u terapiji HIV infekcije
VL  - 66
IS  - 4
SP  - 161
EP  - 173
DO  - 10.5937/arhfarm1604161A
ER  - 

@article{
author = "Anđelković, Milena and Buha, Aleksandra and Vukomanović, Predrag and Matović, Vesna",
year = "2016",
abstract = "Human immunodeficiency virus (HIV), isolated in 1983 by Paster Institute researches, has been recognised as the cause of million fatalies in 21st century. Initial monotherapy failed to show promising results, however, with the development of highly active antiretroviral therapy new era of HIV treatment has started. This new approach resulted in extended life time, reduced development of virus resistance as well as morbidity and mortality of HIV patients. Antiretroviral therapy is longlife and connected with serious adverse and toxic effects. Mitochondrial toxicity can be manifested as periferal lipoathrophy, hepatic steatosis, lactic acidosis, neuropathy and miopathy. Metabolic features associated with lipodystrophy include hypertriglyceridaemia, hypercholesterolaemia, insuline resistance and abnormal glucose tolerance. Hepatotoxicity, nephrotoxicity, osteopenia, rash and gastrointestinal symptoms can also occur during antiretroviral therapy. The aim od this work was to present the most important adverse and toxic effects of drugs used in HIV therapy., Virus humane imunodeficijencije, izolovan zahvaljujući istraživačima Paster Instituta 1983. godine, uzročnik je milionskih žrtava u XXI veku. Kako inicijalna monoterapija nije uspela da pokaže zavidne rezultate, razvojem visoko aktivne antiretrovirusne terapije započeta je nova era HIV terapije. Nov pristup lečenju produžio je životni vek obolelih, smanjio pojavu rezistencija kao i stopu morbiditeta i mortaliteta obolelih. Antiretrovirusna terapija je doživotna i nosi sa sobom ozbiljne neželjene i toksične efekte. Mitohondrijska toksičnost može se ispoljiti kao periferna lipoatrofija, hepatična steatoza, laktična acidoza, neuropatija i miopatija. Metabolički poremaćaji udruženi sa lipodistrofijom uključuju hipertrigliceridemiju, hiperholestirolemiju, insulinsku rezistenciju i abnormalnu glukoznu toleranciju. Hepatotoksičnost, nefrotoksičnost, ostepenija, pojava raša i smetnje na nivou gastroinestinalnog trakta takođe se mogu javiti pri primeni antiretrovirusne terapije. Cilj ovoga rada je bio da da prikaz najznačajnijih neželjenih i toksičnih efekata lekova koji se koriste u terapiji HIV-a.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Safety of antiretroviral drugs, Bezbednost primene lekova koji se koriste u terapiji HIV infekcije",
volume = "66",
number = "4",
pages = "161-173",
doi = "10.5937/arhfarm1604161A"
}

Anđelković, M., Buha, A., Vukomanović, P.,& Matović, V.. (2016). Safety of antiretroviral drugs. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 66(4), 161-173.
https://doi.org/10.5937/arhfarm1604161A

Anđelković M, Buha A, Vukomanović P, Matović V. Safety of antiretroviral drugs. in Arhiv za farmaciju. 2016;66(4):161-173.
doi:10.5937/arhfarm1604161A .

Anđelković, Milena, Buha, Aleksandra, Vukomanović, Predrag, Matović, Vesna, "Safety of antiretroviral drugs" in Arhiv za farmaciju, 66, no. 4 (2016):161-173,
https://doi.org/10.5937/arhfarm1604161A . .

TY  - CONF
AU  - Buha, Aleksandra
AU  - Milovanović, Vesna
AU  - Nikolić, Dragica
AU  - Đukić-Ćosić, Danijela
AU  - Vukomanović, Predrag
AU  - Matović, Vesna
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2368
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Dose dependence of Cd effects of antioxidant defense system in liver of subacutely exposed rats
VL  - 238
IS  - 2, Supplement
SP  - S123
EP  - S124
DO  - 10.1016/j.toxlet.2015.08.393
ER  - 

@conference{
author = "Buha, Aleksandra and Milovanović, Vesna and Nikolić, Dragica and Đukić-Ćosić, Danijela and Vukomanović, Predrag and Matović, Vesna",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Dose dependence of Cd effects of antioxidant defense system in liver of subacutely exposed rats",
volume = "238",
number = "2, Supplement",
pages = "S123-S124",
doi = "10.1016/j.toxlet.2015.08.393"
}

Buha, A., Milovanović, V., Nikolić, D., Đukić-Ćosić, D., Vukomanović, P.,& Matović, V.. (2015). Dose dependence of Cd effects of antioxidant defense system in liver of subacutely exposed rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2, Supplement), S123-S124.
https://doi.org/10.1016/j.toxlet.2015.08.393

Buha A, Milovanović V, Nikolić D, Đukić-Ćosić D, Vukomanović P, Matović V. Dose dependence of Cd effects of antioxidant defense system in liver of subacutely exposed rats. in Toxicology Letters. 2015;238(2, Supplement):S123-S124.
doi:10.1016/j.toxlet.2015.08.393 .

Buha, Aleksandra, Milovanović, Vesna, Nikolić, Dragica, Đukić-Ćosić, Danijela, Vukomanović, Predrag, Matović, Vesna, "Dose dependence of Cd effects of antioxidant defense system in liver of subacutely exposed rats" in Toxicology Letters, 238, no. 2, Supplement (2015):S123-S124,
https://doi.org/10.1016/j.toxlet.2015.08.393 . .

TY  - CONF
AU  - Buha, Aleksandra
AU  - Milovanović, Vesna
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
AU  - Vukomanović, Predrag
AU  - Matović, Vesna
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2238
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Subacute toxicity of PCBs in rats: Is hepatic oxidative stress induction dose dependent?
VL  - 229
IS  - Supplement
SP  - S54
EP  - S54
DO  - 10.1016/j.toxlet.2014.06.223
ER  - 

@conference{
author = "Buha, Aleksandra and Milovanović, Vesna and Antonijević, Biljana and Bulat, Zorica and Vukomanović, Predrag and Matović, Vesna",
year = "2014",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Subacute toxicity of PCBs in rats: Is hepatic oxidative stress induction dose dependent?",
volume = "229",
number = "Supplement",
pages = "S54-S54",
doi = "10.1016/j.toxlet.2014.06.223"
}

Buha, A., Milovanović, V., Antonijević, B., Bulat, Z., Vukomanović, P.,& Matović, V.. (2014). Subacute toxicity of PCBs in rats: Is hepatic oxidative stress induction dose dependent?. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 229(Supplement), S54-S54.
https://doi.org/10.1016/j.toxlet.2014.06.223

Buha A, Milovanović V, Antonijević B, Bulat Z, Vukomanović P, Matović V. Subacute toxicity of PCBs in rats: Is hepatic oxidative stress induction dose dependent?. in Toxicology Letters. 2014;229(Supplement):S54-S54.
doi:10.1016/j.toxlet.2014.06.223 .

Buha, Aleksandra, Milovanović, Vesna, Antonijević, Biljana, Bulat, Zorica, Vukomanović, Predrag, Matović, Vesna, "Subacute toxicity of PCBs in rats: Is hepatic oxidative stress induction dose dependent?" in Toxicology Letters, 229, no. Supplement (2014):S54-S54,
https://doi.org/10.1016/j.toxlet.2014.06.223 . .

TY  - CONF
AU  - Đukić-Ćosić, Danijela
AU  - Vukomanović, Predrag
AU  - Bulat, Zorica
AU  - Ninković, Milica
AU  - Maličević, Živorad
AU  - Matović, Vesna
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1471
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Background explanation of oxidative stress in kidney of mice induced by subacute cadmium intoxication
VL  - 205
IS  - Supplement
SP  - S187
EP  - S187
DO  - 10.1016/j.toxlet.2011.05.648
ER  - 

@conference{
author = "Đukić-Ćosić, Danijela and Vukomanović, Predrag and Bulat, Zorica and Ninković, Milica and Maličević, Živorad and Matović, Vesna",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Background explanation of oxidative stress in kidney of mice induced by subacute cadmium intoxication",
volume = "205",
number = "Supplement",
pages = "S187-S187",
doi = "10.1016/j.toxlet.2011.05.648"
}

Đukić-Ćosić, D., Vukomanović, P., Bulat, Z., Ninković, M., Maličević, Ž.,& Matović, V.. (2011). Background explanation of oxidative stress in kidney of mice induced by subacute cadmium intoxication. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205(Supplement), S187-S187.
https://doi.org/10.1016/j.toxlet.2011.05.648

Đukić-Ćosić D, Vukomanović P, Bulat Z, Ninković M, Maličević Ž, Matović V. Background explanation of oxidative stress in kidney of mice induced by subacute cadmium intoxication. in Toxicology Letters. 2011;205(Supplement):S187-S187.
doi:10.1016/j.toxlet.2011.05.648 .

Đukić-Ćosić, Danijela, Vukomanović, Predrag, Bulat, Zorica, Ninković, Milica, Maličević, Živorad, Matović, Vesna, "Background explanation of oxidative stress in kidney of mice induced by subacute cadmium intoxication" in Toxicology Letters, 205, no. Supplement (2011):S187-S187,
https://doi.org/10.1016/j.toxlet.2011.05.648 . .

TY  - CONF
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Buha, Aleksandra
AU  - Vukomanović, Predrag
AU  - Bulat, Petar
AU  - Matović, Vesna
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1472
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication
VL  - 205
IS  - Supplement
SP  - S194
EP  - S194
DO  - 10.1016/j.toxlet.2011.05.671
ER  - 

@conference{
author = "Bulat, Zorica and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Buha, Aleksandra and Vukomanović, Predrag and Bulat, Petar and Matović, Vesna",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication",
volume = "205",
number = "Supplement",
pages = "S194-S194",
doi = "10.1016/j.toxlet.2011.05.671"
}

Bulat, Z., Đukić-Ćosić, D., Ćurčić, M., Buha, A., Vukomanović, P., Bulat, P.,& Matović, V.. (2011). Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205(Supplement), S194-S194.
https://doi.org/10.1016/j.toxlet.2011.05.671

Bulat Z, Đukić-Ćosić D, Ćurčić M, Buha A, Vukomanović P, Bulat P, Matović V. Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication. in Toxicology Letters. 2011;205(Supplement):S194-S194.
doi:10.1016/j.toxlet.2011.05.671 .

Bulat, Zorica, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Buha, Aleksandra, Vukomanović, Predrag, Bulat, Petar, Matović, Vesna, "Effect of Zn or Cu supplementation on Cd content in blood, liver and kidney of rabbits exposed to prolonged cadmium intoxication" in Toxicology Letters, 205, no. Supplement (2011):S194-S194,
https://doi.org/10.1016/j.toxlet.2011.05.671 . .