TY  - JOUR
AU  - Dmitrasinović, Gordana
AU  - Pešić, Vesna
AU  - Stanić, Dušanka
AU  - Plećaš-Solarović, Bosiljka
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2748
AB  - Background: Physical exercise activates the hypothalamopituitary-adrenal (HPA) axis and induces the body's inflammatory response. Due to contemporary dietary habits and increased energy expenditure, athletes are susceptible to depletion of magnesium ions. The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce damaging stress effects in amateur rugby players. Methods: Rugby players (N=23) were randomly assigned to intervention and control group. Basal samples were collected before intervention group started a 4-week-long supplementation with magnesium (500 mg Mg/d). Blood and saliva sampling were done a day before the match (Day-1), on the morning of competition (Game), and during a six-day-long recovery period (Day1, Day3 and Day6). ACTH, serum/salivary cortisol, IL-6 and total/differential leukocytes counts were determined at each time point. Results: There was a statistically significant increase in ACTH concentration in intervention group compared to control group, while reductions in cortisol concentrations between the two groups were the greatest at Day-1 (p lt 0.01) and at the day of competition (Game) (p lt 0.01). Our results revealed that magnesium completely abolished the increase in IL-6 level noted in control group on Day1 and Day3 vs. Day-1 (p lt 0.01) and also diminished the rise in neutrophil/lymphocyte ratio in intervention group vs. control group (p lt 0.01). Conclusions: These results suggest the possibly important influence magnesium supplementation might have on the change of parameters of HPA axis activity and reduction of immune response activation following strenuous physical exercise such as a rugby game.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation
VL  - 35
IS  - 4
SP  - 375
EP  - 384
DO  - 10.1515/jomb-2016-0021
ER  - 

@article{
author = "Dmitrasinović, Gordana and Pešić, Vesna and Stanić, Dušanka and Plećaš-Solarović, Bosiljka and Dajak, Marijana and Ignjatović, Svetlana",
year = "2016",
abstract = "Background: Physical exercise activates the hypothalamopituitary-adrenal (HPA) axis and induces the body's inflammatory response. Due to contemporary dietary habits and increased energy expenditure, athletes are susceptible to depletion of magnesium ions. The aim of our study was to investigate, through assessment of plasma ACTH, serum IL-6, and salivary/serum cortisol levels, if chronic magnesium supplementation might reduce damaging stress effects in amateur rugby players. Methods: Rugby players (N=23) were randomly assigned to intervention and control group. Basal samples were collected before intervention group started a 4-week-long supplementation with magnesium (500 mg Mg/d). Blood and saliva sampling were done a day before the match (Day-1), on the morning of competition (Game), and during a six-day-long recovery period (Day1, Day3 and Day6). ACTH, serum/salivary cortisol, IL-6 and total/differential leukocytes counts were determined at each time point. Results: There was a statistically significant increase in ACTH concentration in intervention group compared to control group, while reductions in cortisol concentrations between the two groups were the greatest at Day-1 (p lt 0.01) and at the day of competition (Game) (p lt 0.01). Our results revealed that magnesium completely abolished the increase in IL-6 level noted in control group on Day1 and Day3 vs. Day-1 (p lt 0.01) and also diminished the rise in neutrophil/lymphocyte ratio in intervention group vs. control group (p lt 0.01). Conclusions: These results suggest the possibly important influence magnesium supplementation might have on the change of parameters of HPA axis activity and reduction of immune response activation following strenuous physical exercise such as a rugby game.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation",
volume = "35",
number = "4",
pages = "375-384",
doi = "10.1515/jomb-2016-0021"
}

Dmitrasinović, G., Pešić, V., Stanić, D., Plećaš-Solarović, B., Dajak, M.,& Ignjatović, S.. (2016). ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(4), 375-384.
https://doi.org/10.1515/jomb-2016-0021

Dmitrasinović G, Pešić V, Stanić D, Plećaš-Solarović B, Dajak M, Ignjatović S. ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation. in Journal of Medical Biochemistry. 2016;35(4):375-384.
doi:10.1515/jomb-2016-0021 .

Dmitrasinović, Gordana, Pešić, Vesna, Stanić, Dušanka, Plećaš-Solarović, Bosiljka, Dajak, Marijana, Ignjatović, Svetlana, "ACTH, Cortisol and IL-6 Levels in Athletes Following Magnesium Supplementation" in Journal of Medical Biochemistry, 35, no. 4 (2016):375-384,
https://doi.org/10.1515/jomb-2016-0021 . .

TY  - JOUR
AU  - Radosavljević, Branimir
AU  - Žarković, Miloš
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Milinković, Neda
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2700
AB  - Physical effort is known to alter the blood levels of many hormones, but there are only a few studies about the biological changes of salivary hormones. The aim of this work was to determine whether salivary testosterone and salivary cortisol levels, measured two weeks before a half-marathon race, relate to running performance in male recreational athletes. A group of eleven male recreational athletes preparing for a half-marathon was included in the study. Saliva for testosterone and cortisol determinations was collected before and immediately after a 15-km training run, two weeks before the half-marathon. Individual official half-marathon times, expressed in hours, were used as a measure of performance. Mean testosterone concentrations were 1.07 +/- 0.33 nmol/l before the run and 0.88 +/- 0.35 nmol/l after the run (p lt 0.05). Mean cortisol concentrations were 12.28 +/- 8.46 nmol/l before the run and 38.08 +/- 19.63 nmol/l after the run (p lt 0.05). The pre-run salivary testosterone levels marginally correlated with the corresponding half-marathon running times (p=0.068, 95% bootstrap CI for slope -0.40 to -0.06). However, post-run salivary testosterone levels significantly correlated with the corresponding half-marathon running times (p=0.011, 95% bootstrap CI for slope -0.41 to -0.16), even considering correlations with the runners' age. Salivary cortisol levels, either pre- or post-run, did not correlate with the corresponding half-marathon running times. The results of this study suggest that post-exercise salivary testosterone levels could have the potential to predict performance in endurance running, at least in recreational athletes.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Biological aspects of salivary hormones in male half-marathon performance
VL  - 68
IS  - 3
SP  - 495
EP  - 500
DO  - 10.2298/ABS150904038R
ER  - 

@article{
author = "Radosavljević, Branimir and Žarković, Miloš and Ignjatović, Svetlana and Dajak, Marijana and Milinković, Neda",
year = "2016",
abstract = "Physical effort is known to alter the blood levels of many hormones, but there are only a few studies about the biological changes of salivary hormones. The aim of this work was to determine whether salivary testosterone and salivary cortisol levels, measured two weeks before a half-marathon race, relate to running performance in male recreational athletes. A group of eleven male recreational athletes preparing for a half-marathon was included in the study. Saliva for testosterone and cortisol determinations was collected before and immediately after a 15-km training run, two weeks before the half-marathon. Individual official half-marathon times, expressed in hours, were used as a measure of performance. Mean testosterone concentrations were 1.07 +/- 0.33 nmol/l before the run and 0.88 +/- 0.35 nmol/l after the run (p lt 0.05). Mean cortisol concentrations were 12.28 +/- 8.46 nmol/l before the run and 38.08 +/- 19.63 nmol/l after the run (p lt 0.05). The pre-run salivary testosterone levels marginally correlated with the corresponding half-marathon running times (p=0.068, 95% bootstrap CI for slope -0.40 to -0.06). However, post-run salivary testosterone levels significantly correlated with the corresponding half-marathon running times (p=0.011, 95% bootstrap CI for slope -0.41 to -0.16), even considering correlations with the runners' age. Salivary cortisol levels, either pre- or post-run, did not correlate with the corresponding half-marathon running times. The results of this study suggest that post-exercise salivary testosterone levels could have the potential to predict performance in endurance running, at least in recreational athletes.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Biological aspects of salivary hormones in male half-marathon performance",
volume = "68",
number = "3",
pages = "495-500",
doi = "10.2298/ABS150904038R"
}

Radosavljević, B., Žarković, M., Ignjatović, S., Dajak, M.,& Milinković, N.. (2016). Biological aspects of salivary hormones in male half-marathon performance. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 68(3), 495-500.
https://doi.org/10.2298/ABS150904038R

Radosavljević B, Žarković M, Ignjatović S, Dajak M, Milinković N. Biological aspects of salivary hormones in male half-marathon performance. in Archives of Biological Sciences. 2016;68(3):495-500.
doi:10.2298/ABS150904038R .

Radosavljević, Branimir, Žarković, Miloš, Ignjatović, Svetlana, Dajak, Marijana, Milinković, Neda, "Biological aspects of salivary hormones in male half-marathon performance" in Archives of Biological Sciences, 68, no. 3 (2016):495-500,
https://doi.org/10.2298/ABS150904038R . .

TY  - CONF
AU  - Jovičić, Snežana
AU  - Ignjatović, Svetlana
AU  - Kangrga, Ranka
AU  - Dajak, Marijana
AU  - Majkić-Singh, Nada
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5491
AB  - U kliničkoj praksi koristi se nekoliko skorova za
procenu kratkoročnog (10-godišnjeg) rizika od
pojave različitih oblika kardiovaskularnih bolesti
(KVB) koji se zasnivaju na multivarijabilnim regre-
sionim jednačinama izvedenim iz rezultata praćenja
različitih kohortnih grupa. Međutim, pošto je starost
promenljiva kojoj se dodeljuje najveći broj poena u
modelima 10-godišnjeg rizika, mnoge osobe sa zna
čajnim opterećenjem faktorima rizika imaju kratko-
ročni rizik daleko ispod granice koja uslovljava inten-
zivan tretman, iako njihov dugoročni (30-godišnji)
rizik može biti značajan. Takođe, drugi biomarkeri
mogu da identifikuju osobe sa većim kardiovasku-
larnim rizikom od onog izračunatog primenom skoro-
va kratkoročnog rizika. Cilj rada bio je da se analizira
priroda uticaja ispitivanih biomarkera na kardiovas-
kularni rizik i njihovo grupisanje, kao i povezanost
dobijenih faktora sa kategorizacijom 30-godišnjeg
rizika faktorskom analizom. Pomoću interaktivnog
kalkulatora »30-year risk of cardiovascular disease«
izračunavan je dugoročni 30-godišnji rizik za pojavu
»kompletne« KVB (sve manifestacije KVB) i »teške«
KVB (potencijalno fatalne komplikacije KVB). Analiza
glavnih komponenti je korišćena za ispitivanje
grupisanja markera inflamacije [visoko-osetljivi C-
reaktivni protein (hsCRP), serumski amiloid A (SAA),
fibrinogen, a1-kiseli glikoprotein (A1AGP), haptoglo-
bin, C3 i C4 komponente komplementa], metabo-lizma lipida [non-HDL i LDL holesterol, trigliceridi,
apolipoprotein A-I (apo A-I), apolipoprotein B (apo
B), lipoprotein (a) (Lp(a))], bubrežne [kreatinin,
mokraćna kiselina, cistatin C (Cys-C)] i srčane funk-
cije [N-terminalni pro-natriuretički peptid tip B (NT-
proBNP), visoko-osetljivi srčani troponin T (hs-cTnT)],
dobijenih analizom uzoraka seruma 242 zdrave oso-
be. Faktorskom analizom identifikovano je 5 klastera,
kojima je objašnjeno je 67,4% ukupne varijacije, ras-
poređene na sledeći način 1) 29,7% »sistemska infla-
macija« (hsCRP, fibrinogen, SAA, A1AGP, haptoglo-
bin, C3 i C4 komponenta komplementa); 2) 12,5%
»aterogena dislipidemija« (LDL i non-HDL holesterol,
apo B i trigliceridi); 3) 11,0% »kardiorenalni faktor«
(kreatinin, mokraćna kiselina, Cys-C i hs-cTnT); 4)
7,6% »hemodinamski faktor« (NT-proBNP) i 5) 6,7%
»lipoproteinski faktor« [apo A-I, Lp(a)]. Prediktivne
vrednosti u proceni 30-godišnjeg rizika za »komplet-
nu KVB« i »tešku KVB« su bile značajne za četiri fak-
tora (OR 1,892–5,590; P<0,0001 i OR 2,183–
5,931; P<0,0001, redom), a »hemodinamski fak-
tor« nije imao statistički značajan prediktivni potenci-
jal za vrednosti iznad optimalnih/normalnih za odgo-
varajući pol i starost (P>0,05). Površine ispod ROC
krivih (AUC) modela sa pet faktora u predikciji
povećanog 30-godišnjeg rizika za »kompletnu KVB« i
»tešku KVB« iznosile su 0,881 i 0,888, redom, i nisu
bile statistički značajno različite od multivarijabilnog
logističkog modela od 18 polaznih parametara
(0,892 i 0,901; P>0,05; redom). Sistemska inflama-
cija, aterogena dislipidemija, kardiorenalna funkcija i
lipoproteinski status nezavisno doprinose dugo-
ročnom, 30-godišnjem riziku iznad normalnog/opti-
malnog kako za ozbiljne komplikacije KVB, tako i za
sve vrste kardiovaskularnih komplikacija.
AB  - Several risk score algorithms for short-term (10-
year) cardiovascular risk assessment based on multi-
variable regression equations derived from different
cohorts are being used in clinical practice. However,
since the age is variable with the strongest influence
on short-term risk, many individuals with moderate
increase of other traditional risk factors would have a
10-year risk below cutoff for intensive treatment, but
a significant long-term (30-year) risk. Also, other bio-
markers might identify persons with higher actual
cardiovascular risk compared with calculated using
short-term risk scores. The aim of this study was to
analyze the nature of influence of examined biomark-
ers on cardiovascular risk and their clustering, as well
as relations of identified factors with long-term 30-
year risk categorization, using factor analysis.
Interactive calculator »30-year risk of cardiovascular
disease« was used for long-term 30-year risk calcula-
tion, for both »full CVD« (all manifestations of cardio-
vascular disease) and »hard CVD« (serious manifesta-
tions of CVD). Principal component analysis was used
to investigate clustering of markers of inflammation
[high sensitivity C-reactive protein (hsCRP), serum
amyloid A (SAA), fibrinogen, a1-acid glycoprotein
(A1AGP), haptoglobin, C3 and C4 complement
components], lipid metabolism [non-HDL and LDL
cholesterol, triglycerides, apolipoprotein A-I (apo A-
I), apolipoprotein B (apo B), lipoprotein (a) (Lp(a))], renal [creatinine, uric acid, cystatin C (Cys-C)] and
cardiac function [N-terminal pro-natriuretic peptide
type B (NT-proBNP), high sensitivity cardiac troponin
T (hs-cTnT)], obtained from 242 apparently healthy
individuals. Factor analysis identified five clusters,
which explained 67.4% of the total variance distrib-
uted as follows: 1) 29.7% »systemic inflammation«
(hsCRP, fibrinogen, SAA, A1AGP, haptoglobin, C3,
C4); 2) 12.5% »atherogenic dyslipidemia«, (LDL and
non-HDL cholesterol, apo B, triglycerides); 3) 11.0%
»cardiorenal factor« (creatinine, uric acid, Cys-C, hs-
cTnT); 4) 7.6% »hemodynamic factor« (NT-proBNP);
and 5) 6.7% »lipoprotein factor« [apo A-I, Lp(a)].
When estimating 30-year risk from both »full CVD«
and »hard CVD«, predictive values were significant
for four factors (OR 1.892–5.590, P<0.0001 and
OR 2.183–5.931, P<0.0001, respectively), and
»hemodynamic factor« had no statistical significance
in predicting potential for values above optimal/nor-
mal for corresponding gender and age (P>0.05).
The areas under the receiver operating characteristic
curves (AUCs) of the five factor model in predicting
increased 30-year risk for »full CVD« and »hard CVD«
were 0.881 and 0.888, respectively, which were not
statistically significantly different from AUCs of the
multivariable logistic model of 18 original parameters
(0.892 and 0.901, P>0.05, respectively). Long-
term, 30-year risk above normal/optimal for hard
CVD complications and for all kinds of cardiovascular
complications was independently contributed by sys-
temic inflammation, atherogenic dyslipidemia, car-
diorenal function and lipoprotein status.
PB  - Društvo medicinskih biohemičara Srbije, Beograd
C3  - XIX kongres medicinske i laboratorijske medicine sa me|unarodnim učešćem, 2015, Journal of Medical Chemistry, 34, 1, 2015.
T1  - Faktorska analiza povezanosti inflamatornih, lipidnih, srčanih i bubrežnih biomarkera sa Klasifikacijom dugoročnog 30-godišnjeg kardiovaskularnog rizika
T1  - Factor analysis of association of lipid, inflammatory, cardiac and renal biomarkers with long-term 30-year cardiovascular risk classification
VL  - 34
SP  - 68
EP  - 69
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5491
ER  - 

@conference{
author = "Jovičić, Snežana and Ignjatović, Svetlana and Kangrga, Ranka and Dajak, Marijana and Majkić-Singh, Nada",
year = "2015",
abstract = "U kliničkoj praksi koristi se nekoliko skorova za
procenu kratkoročnog (10-godišnjeg) rizika od
pojave različitih oblika kardiovaskularnih bolesti
(KVB) koji se zasnivaju na multivarijabilnim regre-
sionim jednačinama izvedenim iz rezultata praćenja
različitih kohortnih grupa. Međutim, pošto je starost
promenljiva kojoj se dodeljuje najveći broj poena u
modelima 10-godišnjeg rizika, mnoge osobe sa zna
čajnim opterećenjem faktorima rizika imaju kratko-
ročni rizik daleko ispod granice koja uslovljava inten-
zivan tretman, iako njihov dugoročni (30-godišnji)
rizik može biti značajan. Takođe, drugi biomarkeri
mogu da identifikuju osobe sa većim kardiovasku-
larnim rizikom od onog izračunatog primenom skoro-
va kratkoročnog rizika. Cilj rada bio je da se analizira
priroda uticaja ispitivanih biomarkera na kardiovas-
kularni rizik i njihovo grupisanje, kao i povezanost
dobijenih faktora sa kategorizacijom 30-godišnjeg
rizika faktorskom analizom. Pomoću interaktivnog
kalkulatora »30-year risk of cardiovascular disease«
izračunavan je dugoročni 30-godišnji rizik za pojavu
»kompletne« KVB (sve manifestacije KVB) i »teške«
KVB (potencijalno fatalne komplikacije KVB). Analiza
glavnih komponenti je korišćena za ispitivanje
grupisanja markera inflamacije [visoko-osetljivi C-
reaktivni protein (hsCRP), serumski amiloid A (SAA),
fibrinogen, a1-kiseli glikoprotein (A1AGP), haptoglo-
bin, C3 i C4 komponente komplementa], metabo-lizma lipida [non-HDL i LDL holesterol, trigliceridi,
apolipoprotein A-I (apo A-I), apolipoprotein B (apo
B), lipoprotein (a) (Lp(a))], bubrežne [kreatinin,
mokraćna kiselina, cistatin C (Cys-C)] i srčane funk-
cije [N-terminalni pro-natriuretički peptid tip B (NT-
proBNP), visoko-osetljivi srčani troponin T (hs-cTnT)],
dobijenih analizom uzoraka seruma 242 zdrave oso-
be. Faktorskom analizom identifikovano je 5 klastera,
kojima je objašnjeno je 67,4% ukupne varijacije, ras-
poređene na sledeći način 1) 29,7% »sistemska infla-
macija« (hsCRP, fibrinogen, SAA, A1AGP, haptoglo-
bin, C3 i C4 komponenta komplementa); 2) 12,5%
»aterogena dislipidemija« (LDL i non-HDL holesterol,
apo B i trigliceridi); 3) 11,0% »kardiorenalni faktor«
(kreatinin, mokraćna kiselina, Cys-C i hs-cTnT); 4)
7,6% »hemodinamski faktor« (NT-proBNP) i 5) 6,7%
»lipoproteinski faktor« [apo A-I, Lp(a)]. Prediktivne
vrednosti u proceni 30-godišnjeg rizika za »komplet-
nu KVB« i »tešku KVB« su bile značajne za četiri fak-
tora (OR 1,892–5,590; P<0,0001 i OR 2,183–
5,931; P<0,0001, redom), a »hemodinamski fak-
tor« nije imao statistički značajan prediktivni potenci-
jal za vrednosti iznad optimalnih/normalnih za odgo-
varajući pol i starost (P>0,05). Površine ispod ROC
krivih (AUC) modela sa pet faktora u predikciji
povećanog 30-godišnjeg rizika za »kompletnu KVB« i
»tešku KVB« iznosile su 0,881 i 0,888, redom, i nisu
bile statistički značajno različite od multivarijabilnog
logističkog modela od 18 polaznih parametara
(0,892 i 0,901; P>0,05; redom). Sistemska inflama-
cija, aterogena dislipidemija, kardiorenalna funkcija i
lipoproteinski status nezavisno doprinose dugo-
ročnom, 30-godišnjem riziku iznad normalnog/opti-
malnog kako za ozbiljne komplikacije KVB, tako i za
sve vrste kardiovaskularnih komplikacija., Several risk score algorithms for short-term (10-
year) cardiovascular risk assessment based on multi-
variable regression equations derived from different
cohorts are being used in clinical practice. However,
since the age is variable with the strongest influence
on short-term risk, many individuals with moderate
increase of other traditional risk factors would have a
10-year risk below cutoff for intensive treatment, but
a significant long-term (30-year) risk. Also, other bio-
markers might identify persons with higher actual
cardiovascular risk compared with calculated using
short-term risk scores. The aim of this study was to
analyze the nature of influence of examined biomark-
ers on cardiovascular risk and their clustering, as well
as relations of identified factors with long-term 30-
year risk categorization, using factor analysis.
Interactive calculator »30-year risk of cardiovascular
disease« was used for long-term 30-year risk calcula-
tion, for both »full CVD« (all manifestations of cardio-
vascular disease) and »hard CVD« (serious manifesta-
tions of CVD). Principal component analysis was used
to investigate clustering of markers of inflammation
[high sensitivity C-reactive protein (hsCRP), serum
amyloid A (SAA), fibrinogen, a1-acid glycoprotein
(A1AGP), haptoglobin, C3 and C4 complement
components], lipid metabolism [non-HDL and LDL
cholesterol, triglycerides, apolipoprotein A-I (apo A-
I), apolipoprotein B (apo B), lipoprotein (a) (Lp(a))], renal [creatinine, uric acid, cystatin C (Cys-C)] and
cardiac function [N-terminal pro-natriuretic peptide
type B (NT-proBNP), high sensitivity cardiac troponin
T (hs-cTnT)], obtained from 242 apparently healthy
individuals. Factor analysis identified five clusters,
which explained 67.4% of the total variance distrib-
uted as follows: 1) 29.7% »systemic inflammation«
(hsCRP, fibrinogen, SAA, A1AGP, haptoglobin, C3,
C4); 2) 12.5% »atherogenic dyslipidemia«, (LDL and
non-HDL cholesterol, apo B, triglycerides); 3) 11.0%
»cardiorenal factor« (creatinine, uric acid, Cys-C, hs-
cTnT); 4) 7.6% »hemodynamic factor« (NT-proBNP);
and 5) 6.7% »lipoprotein factor« [apo A-I, Lp(a)].
When estimating 30-year risk from both »full CVD«
and »hard CVD«, predictive values were significant
for four factors (OR 1.892–5.590, P<0.0001 and
OR 2.183–5.931, P<0.0001, respectively), and
»hemodynamic factor« had no statistical significance
in predicting potential for values above optimal/nor-
mal for corresponding gender and age (P>0.05).
The areas under the receiver operating characteristic
curves (AUCs) of the five factor model in predicting
increased 30-year risk for »full CVD« and »hard CVD«
were 0.881 and 0.888, respectively, which were not
statistically significantly different from AUCs of the
multivariable logistic model of 18 original parameters
(0.892 and 0.901, P>0.05, respectively). Long-
term, 30-year risk above normal/optimal for hard
CVD complications and for all kinds of cardiovascular
complications was independently contributed by sys-
temic inflammation, atherogenic dyslipidemia, car-
diorenal function and lipoprotein status.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd",
journal = "XIX kongres medicinske i laboratorijske medicine sa me|unarodnim učešćem, 2015, Journal of Medical Chemistry, 34, 1, 2015.",
title = "Faktorska analiza povezanosti inflamatornih, lipidnih, srčanih i bubrežnih biomarkera sa Klasifikacijom dugoročnog 30-godišnjeg kardiovaskularnog rizika, Factor analysis of association of lipid, inflammatory, cardiac and renal biomarkers with long-term 30-year cardiovascular risk classification",
volume = "34",
pages = "68-69",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5491"
}

Jovičić, S., Ignjatović, S., Kangrga, R., Dajak, M.,& Majkić-Singh, N.. (2015). Faktorska analiza povezanosti inflamatornih, lipidnih, srčanih i bubrežnih biomarkera sa Klasifikacijom dugoročnog 30-godišnjeg kardiovaskularnog rizika. in XIX kongres medicinske i laboratorijske medicine sa me|unarodnim učešćem, 2015, Journal of Medical Chemistry, 34, 1, 2015.
Društvo medicinskih biohemičara Srbije, Beograd., 34, 68-69.
https://hdl.handle.net/21.15107/rcub_farfar_5491

Jovičić S, Ignjatović S, Kangrga R, Dajak M, Majkić-Singh N. Faktorska analiza povezanosti inflamatornih, lipidnih, srčanih i bubrežnih biomarkera sa Klasifikacijom dugoročnog 30-godišnjeg kardiovaskularnog rizika. in XIX kongres medicinske i laboratorijske medicine sa me|unarodnim učešćem, 2015, Journal of Medical Chemistry, 34, 1, 2015.. 2015;34:68-69.
https://hdl.handle.net/21.15107/rcub_farfar_5491 .

Jovičić, Snežana, Ignjatović, Svetlana, Kangrga, Ranka, Dajak, Marijana, Majkić-Singh, Nada, "Faktorska analiza povezanosti inflamatornih, lipidnih, srčanih i bubrežnih biomarkera sa Klasifikacijom dugoročnog 30-godišnjeg kardiovaskularnog rizika" in XIX kongres medicinske i laboratorijske medicine sa me|unarodnim učešćem, 2015, Journal of Medical Chemistry, 34, 1, 2015., 34 (2015):68-69,
https://hdl.handle.net/21.15107/rcub_farfar_5491 .

TY  - JOUR
AU  - Zogović, Dušanka
AU  - Pešić, Vesna
AU  - Dmitrasinović, Gordana
AU  - Dajak, Marijana
AU  - Plećaš, Bosiljka
AU  - Batinić, Bojan
AU  - Popović, Dejana
AU  - Ignjatović, Svetlana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2237
AB  - Background: Sleep deprivation, malnutrition and lack of physical activity are contemporary stress-related factors present in the student population. Stress activates the HPA and often suppresses the HPG axis, but also influences cytokine synthesis and consequently regulates immune response. Since magnesium deficiency facilitates negative pathophysiological consequences, a reasonable question imposes, wheth er Mg supplementation might correct the adrenal/go nadal hormone balance and immuno-endocrine function. Methods: Fifteen male students were given 2 x 250 mg Mg for four weeks. Serum levels of FSH, LH, testosterone (T), ACTH and cortisol
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students
VL  - 33
IS  - 3
SP  - 291
EP  - 298
DO  - 10.2478/jomb-2014-0016
ER  - 

@article{
author = "Zogović, Dušanka and Pešić, Vesna and Dmitrasinović, Gordana and Dajak, Marijana and Plećaš, Bosiljka and Batinić, Bojan and Popović, Dejana and Ignjatović, Svetlana",
year = "2014",
abstract = "Background: Sleep deprivation, malnutrition and lack of physical activity are contemporary stress-related factors present in the student population. Stress activates the HPA and often suppresses the HPG axis, but also influences cytokine synthesis and consequently regulates immune response. Since magnesium deficiency facilitates negative pathophysiological consequences, a reasonable question imposes, wheth er Mg supplementation might correct the adrenal/go nadal hormone balance and immuno-endocrine function. Methods: Fifteen male students were given 2 x 250 mg Mg for four weeks. Serum levels of FSH, LH, testosterone (T), ACTH and cortisol",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students",
volume = "33",
number = "3",
pages = "291-298",
doi = "10.2478/jomb-2014-0016"
}

Zogović, D., Pešić, V., Dmitrasinović, G., Dajak, M., Plećaš, B., Batinić, B., Popović, D.,& Ignjatović, S.. (2014). Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 33(3), 291-298.
https://doi.org/10.2478/jomb-2014-0016

Zogović D, Pešić V, Dmitrasinović G, Dajak M, Plećaš B, Batinić B, Popović D, Ignjatović S. Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students. in Journal of Medical Biochemistry. 2014;33(3):291-298.
doi:10.2478/jomb-2014-0016 .

Zogović, Dušanka, Pešić, Vesna, Dmitrasinović, Gordana, Dajak, Marijana, Plećaš, Bosiljka, Batinić, Bojan, Popović, Dejana, Ignjatović, Svetlana, "Pituitary-gonadal, pituitary-adrenocortical hormones and IL-6 levels following long-term magnesium supplementation in male students" in Journal of Medical Biochemistry, 33, no. 3 (2014):291-298,
https://doi.org/10.2478/jomb-2014-0016 . .

TY  - JOUR
AU  - Dobrić, Milan
AU  - Giga, Vojislav
AU  - Beleslin, Branko
AU  - Ignjatović, Svetlana
AU  - Paunović, Ivana
AU  - Stepanović, Jelena M.
AU  - Đorđević-Dikić, Ana
AU  - Kostić, Jelena
AU  - Nedeljković, Ivana
AU  - Nedeljković, Milan
AU  - Tesić, Milorad
AU  - Dajak, Marijana
AU  - Ostojić, Miodrag
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1868
AB  - Background: Glycogen phosphorylase BB (GPBB) is released from cardiac cells during myocyte damage. Previous studies have shown contradictory results regarding the relation of enzyme release and reversible myocardial ischemia. The aim of this study was to determine the plasma kinetics of GPBB as a response to the exercise stress echocardiographic test (ESET), and to define the relationship between myocardial ischemia and enzyme plasma concentrations. Methods: We studied 46 consecutive patients undergoing ESET, with recent coronary angiography. In all patients, a submaximal stress echo test according to Bruce protocol was performed. Concentration of GPBB was measured in peripheral blood that was sampled 5 min before and 10, 30 and 60 min after ESET. Results: There was significant increase of GPBB concentration after the test (p=0.021). Significant increase was detected 30 min (34.9% increase, p=0.021) and 60 min (34.5% increase, p=0.016) after ESET. There was no significant effect of myocardial ischemia on GPBB concentrations (p=0.126), and no significant interaction between sampling intervals and myocardial ischemia, suggesting a similar release profile of GPBB in ischemic and non-ischemic conditions (p=0.558). Patients in whom ESET was terminated later (stages 4 or 5 of standard Bruce protocol; n=13) had higher GPBB concentrations than patients who terminated ESET earlier (stages 1, 2 or 3; n=33) (p=0.049). Baseline GPBB concentration was not correlated to any of the patients' demographic, clinical and hemodynamic characteristics. Conclusions: GPBB plasma concentration increases after ESET, and it is not related to inducible myocardial ischemia. However, it seems that GPBB release during ESET might be related to exercise load/duration.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test
VL  - 51
IS  - 10
SP  - 2029
EP  - 2035
DO  - 10.1515/cclm-2013-0109
ER  - 

@article{
author = "Dobrić, Milan and Giga, Vojislav and Beleslin, Branko and Ignjatović, Svetlana and Paunović, Ivana and Stepanović, Jelena M. and Đorđević-Dikić, Ana and Kostić, Jelena and Nedeljković, Ivana and Nedeljković, Milan and Tesić, Milorad and Dajak, Marijana and Ostojić, Miodrag",
year = "2013",
abstract = "Background: Glycogen phosphorylase BB (GPBB) is released from cardiac cells during myocyte damage. Previous studies have shown contradictory results regarding the relation of enzyme release and reversible myocardial ischemia. The aim of this study was to determine the plasma kinetics of GPBB as a response to the exercise stress echocardiographic test (ESET), and to define the relationship between myocardial ischemia and enzyme plasma concentrations. Methods: We studied 46 consecutive patients undergoing ESET, with recent coronary angiography. In all patients, a submaximal stress echo test according to Bruce protocol was performed. Concentration of GPBB was measured in peripheral blood that was sampled 5 min before and 10, 30 and 60 min after ESET. Results: There was significant increase of GPBB concentration after the test (p=0.021). Significant increase was detected 30 min (34.9% increase, p=0.021) and 60 min (34.5% increase, p=0.016) after ESET. There was no significant effect of myocardial ischemia on GPBB concentrations (p=0.126), and no significant interaction between sampling intervals and myocardial ischemia, suggesting a similar release profile of GPBB in ischemic and non-ischemic conditions (p=0.558). Patients in whom ESET was terminated later (stages 4 or 5 of standard Bruce protocol; n=13) had higher GPBB concentrations than patients who terminated ESET earlier (stages 1, 2 or 3; n=33) (p=0.049). Baseline GPBB concentration was not correlated to any of the patients' demographic, clinical and hemodynamic characteristics. Conclusions: GPBB plasma concentration increases after ESET, and it is not related to inducible myocardial ischemia. However, it seems that GPBB release during ESET might be related to exercise load/duration.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test",
volume = "51",
number = "10",
pages = "2029-2035",
doi = "10.1515/cclm-2013-0109"
}

Dobrić, M., Giga, V., Beleslin, B., Ignjatović, S., Paunović, I., Stepanović, J. M., Đorđević-Dikić, A., Kostić, J., Nedeljković, I., Nedeljković, M., Tesić, M., Dajak, M.,& Ostojić, M.. (2013). Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 51(10), 2029-2035.
https://doi.org/10.1515/cclm-2013-0109

Dobrić M, Giga V, Beleslin B, Ignjatović S, Paunović I, Stepanović JM, Đorđević-Dikić A, Kostić J, Nedeljković I, Nedeljković M, Tesić M, Dajak M, Ostojić M. Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test. in Clinical Chemistry and Laboratory Medicine. 2013;51(10):2029-2035.
doi:10.1515/cclm-2013-0109 .

Dobrić, Milan, Giga, Vojislav, Beleslin, Branko, Ignjatović, Svetlana, Paunović, Ivana, Stepanović, Jelena M., Đorđević-Dikić, Ana, Kostić, Jelena, Nedeljković, Ivana, Nedeljković, Milan, Tesić, Milorad, Dajak, Marijana, Ostojić, Miodrag, "Glycogen phosphorylase isoenzyme BB plasma kinetics is not related to myocardial ischemia induced by exercise stress echo test" in Clinical Chemistry and Laboratory Medicine, 51, no. 10 (2013):2029-2035,
https://doi.org/10.1515/cclm-2013-0109 . .

TY  - JOUR
AU  - Lezaić, V.
AU  - Mirković, Duško
AU  - Ristić, S.
AU  - Radivojević, Dragana
AU  - Dajak, Marijana
AU  - Naumović, Radomir
AU  - Marinković, Jelena
AU  - Đukanović, Ljubica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1963
AB  - Purpose. Because no consensus exists regarding the most accurate calculation to estimate glomerular filtration rate (GFR) based on serum creatinine concentrations (sCr) after kidney transplantation, this study sought to assess the potential role of tubular dysfunction on GFR estimates using various equations as well as the effect of pharmacologic blockades on tubular secretion of creatinine on creatinine clearance (ClCr). Methods. Iohexol GFR (mGFR) was performed in 17 stable kidney transplant recipients(R) at >24 months post-transplantation. Their mean age was 48.3 +/- 11.3 years. All R were treated with a calcineurin inhibitor (CNI). At the time of study we measured sCr, 24 hour-ClCr, cystatin C, 24-hour proteinuria, microalbuminuria, FE Na, alfa1-microglobulinuria (alfa1-MG), and CNI concentrations. To block tubular secretion of Cr, recipients were prescribed cimetidine (2400 mg) 2 days before the sCr measurement. Additionally, to exclude dietary influences on sCr, R did not eat meat for 2 days before testing. GFR was estimated using the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockroft-Gault (C&G), and Cystatin C (Cyst C) GFR equations. Mean kidney graft function over the previous 6 months was used as the contra. Pearson correlation was determined between the differences between mGFR and estimatedGFR: Iohexol minus MDRD, EPI, Cyst C or C&G GFR for paired estimates. The diagnostic accuracy of the eGFRs to detect an mGFR of 60 mL/min/1.73 m(2) was examined by receiver operating characteristic curves. Results. Mean mGFR was 75.2 +/- 35.8 mL/min/1.73 m2. The sCr increased but the 24-hour ClCr, MDRD, EPI, and C&G decreased after vs before cimetidine. The difference was significant for sCr (F = 12.933; P = .002) and MDRD GFR (F = 15.750; P = .001). mGFR was not significantly higher than all pair values of eGFRs, and not significantly lower than 24-hour ClCr before and after cimetidine. However, in comparison to all eGFRs, ClCr after cimetidine most approached mGFR. A significant positive correlation was observed between alfa1-MG and the difference between mGFR and MDRD (before, r = .543 [P = .045]; after cimeticline, 0.568 [P = .034]), EPI (before, r = 0.516 [P = .050]; after cimetidine, r = 0.562 [P = .0361), and ClCr (r = 0.633; P = .016), C&G (P = .581; P = .029) before cimetidine. Accuracy of eGFRs to detect mGFR of 60 mL/min/1.73 m(2) showed EPI GFR before cimetidine to show diagnostic accuracy for patients with GFR >60 mL/min/1.73 m(2) with a sensitivity of 81.8% and a specificity of 71.4%.
PB  - Elsevier Science Inc, New York
T2  - Turkish Journal of Medical Sciences
T1  - Potential Influence of Tubular Dysfunction on the Difference Between Estimated and Measured Glomerular Filtration Rate After Kidney Transplantation
VL  - 45
IS  - 4
SP  - 1651
EP  - 1654
DO  - 10.1016/j.transproceed.2013.02.105
ER  - 

@article{
author = "Lezaić, V. and Mirković, Duško and Ristić, S. and Radivojević, Dragana and Dajak, Marijana and Naumović, Radomir and Marinković, Jelena and Đukanović, Ljubica",
year = "2013",
abstract = "Purpose. Because no consensus exists regarding the most accurate calculation to estimate glomerular filtration rate (GFR) based on serum creatinine concentrations (sCr) after kidney transplantation, this study sought to assess the potential role of tubular dysfunction on GFR estimates using various equations as well as the effect of pharmacologic blockades on tubular secretion of creatinine on creatinine clearance (ClCr). Methods. Iohexol GFR (mGFR) was performed in 17 stable kidney transplant recipients(R) at >24 months post-transplantation. Their mean age was 48.3 +/- 11.3 years. All R were treated with a calcineurin inhibitor (CNI). At the time of study we measured sCr, 24 hour-ClCr, cystatin C, 24-hour proteinuria, microalbuminuria, FE Na, alfa1-microglobulinuria (alfa1-MG), and CNI concentrations. To block tubular secretion of Cr, recipients were prescribed cimetidine (2400 mg) 2 days before the sCr measurement. Additionally, to exclude dietary influences on sCr, R did not eat meat for 2 days before testing. GFR was estimated using the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Cockroft-Gault (C&G), and Cystatin C (Cyst C) GFR equations. Mean kidney graft function over the previous 6 months was used as the contra. Pearson correlation was determined between the differences between mGFR and estimatedGFR: Iohexol minus MDRD, EPI, Cyst C or C&G GFR for paired estimates. The diagnostic accuracy of the eGFRs to detect an mGFR of 60 mL/min/1.73 m(2) was examined by receiver operating characteristic curves. Results. Mean mGFR was 75.2 +/- 35.8 mL/min/1.73 m2. The sCr increased but the 24-hour ClCr, MDRD, EPI, and C&G decreased after vs before cimetidine. The difference was significant for sCr (F = 12.933; P = .002) and MDRD GFR (F = 15.750; P = .001). mGFR was not significantly higher than all pair values of eGFRs, and not significantly lower than 24-hour ClCr before and after cimetidine. However, in comparison to all eGFRs, ClCr after cimetidine most approached mGFR. A significant positive correlation was observed between alfa1-MG and the difference between mGFR and MDRD (before, r = .543 [P = .045]; after cimeticline, 0.568 [P = .034]), EPI (before, r = 0.516 [P = .050]; after cimetidine, r = 0.562 [P = .0361), and ClCr (r = 0.633; P = .016), C&G (P = .581; P = .029) before cimetidine. Accuracy of eGFRs to detect mGFR of 60 mL/min/1.73 m(2) showed EPI GFR before cimetidine to show diagnostic accuracy for patients with GFR >60 mL/min/1.73 m(2) with a sensitivity of 81.8% and a specificity of 71.4%.",
publisher = "Elsevier Science Inc, New York",
journal = "Turkish Journal of Medical Sciences",
title = "Potential Influence of Tubular Dysfunction on the Difference Between Estimated and Measured Glomerular Filtration Rate After Kidney Transplantation",
volume = "45",
number = "4",
pages = "1651-1654",
doi = "10.1016/j.transproceed.2013.02.105"
}

Lezaić, V., Mirković, D., Ristić, S., Radivojević, D., Dajak, M., Naumović, R., Marinković, J.,& Đukanović, L.. (2013). Potential Influence of Tubular Dysfunction on the Difference Between Estimated and Measured Glomerular Filtration Rate After Kidney Transplantation. in Turkish Journal of Medical Sciences
Elsevier Science Inc, New York., 45(4), 1651-1654.
https://doi.org/10.1016/j.transproceed.2013.02.105

Lezaić V, Mirković D, Ristić S, Radivojević D, Dajak M, Naumović R, Marinković J, Đukanović L. Potential Influence of Tubular Dysfunction on the Difference Between Estimated and Measured Glomerular Filtration Rate After Kidney Transplantation. in Turkish Journal of Medical Sciences. 2013;45(4):1651-1654.
doi:10.1016/j.transproceed.2013.02.105 .

Lezaić, V., Mirković, Duško, Ristić, S., Radivojević, Dragana, Dajak, Marijana, Naumović, Radomir, Marinković, Jelena, Đukanović, Ljubica, "Potential Influence of Tubular Dysfunction on the Difference Between Estimated and Measured Glomerular Filtration Rate After Kidney Transplantation" in Turkish Journal of Medical Sciences, 45, no. 4 (2013):1651-1654,
https://doi.org/10.1016/j.transproceed.2013.02.105 . .

TY  - JOUR
AU  - Pejović, Janko
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Majkić-Singh, Nada
AU  - Vučinić, Žarko
AU  - Pavlović, Miroslav
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1854
AB  - Background/Aim. Identification of patients with arterial hypertension and a possible onset of heart failure by determining the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) enables timely intensification of treatment and allows clinicians to prescribe and implement optimal and appropriate care. The aim of this study was to evaluate NT-proBNP in patients with longstanding hypertension and in patients with signs of hypertensive cardiomyopathy. Methods. The study involved 3 groups, with 50 subjects each: "healthy" persons (control group), patients with hypertension and normal left ventricular systolic function (group 1) and patients with longstanding hypertension and signs of hypertensive cardiomyopathy with impaired left ventricular systolic function (group 2). We measured levels of NT-proBNP, C-reactive protein and creatinine according to the manufacturer's instructions. All the patients were clinically examined including physical examination of the heart with blood pressure, pulse rate, electrocardiogram (ECG) and echocardiogram. Results. Our results showed that the determined parameters generally differed significantly (Student's t-test) among the groups. The mean (+/- SD) values of NT-proBNP in the control group, group 1 and group 2 were: 2.794 (+/- 1.515) pmol/L, 9.575 (+/- 5.449) pmol/L and 204.60 (84,93) pmol/L, respectively. NT-proBNP correlated significantly with the determined parameters both in the group 1 and the group 2. In the group 1, the highest correlation was obtained with C-reactive protein (r = 0.8424). In the group 2, the highest correlation was obtained with ejection fraction (r = -0.9111). NT-proBNP showed progressive increase in proportion to the New York Heart Association (NYHA) classification. The patients in the- group 2 who belonged to the II and III NYHA class had significantly higher levels of NT-proBNP than those in the NYHA class I (ANOVA test,p = 0.001). Conclusion. The obtained results suggest that NT-proBNP is a useful biomarker in the treatment of patients with longstanding hypertension who are at risk for heart failure.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters in patients with hypertension
VL  - 70
IS  - 8
SP  - 728
EP  - 734
DO  - 10.2298/VSP110322048P
ER  - 

@article{
author = "Pejović, Janko and Ignjatović, Svetlana and Dajak, Marijana and Majkić-Singh, Nada and Vučinić, Žarko and Pavlović, Miroslav",
year = "2013",
abstract = "Background/Aim. Identification of patients with arterial hypertension and a possible onset of heart failure by determining the concentration of N-terminal pro-B-type natriuretic peptide (NT-proBNP) enables timely intensification of treatment and allows clinicians to prescribe and implement optimal and appropriate care. The aim of this study was to evaluate NT-proBNP in patients with longstanding hypertension and in patients with signs of hypertensive cardiomyopathy. Methods. The study involved 3 groups, with 50 subjects each: "healthy" persons (control group), patients with hypertension and normal left ventricular systolic function (group 1) and patients with longstanding hypertension and signs of hypertensive cardiomyopathy with impaired left ventricular systolic function (group 2). We measured levels of NT-proBNP, C-reactive protein and creatinine according to the manufacturer's instructions. All the patients were clinically examined including physical examination of the heart with blood pressure, pulse rate, electrocardiogram (ECG) and echocardiogram. Results. Our results showed that the determined parameters generally differed significantly (Student's t-test) among the groups. The mean (+/- SD) values of NT-proBNP in the control group, group 1 and group 2 were: 2.794 (+/- 1.515) pmol/L, 9.575 (+/- 5.449) pmol/L and 204.60 (84,93) pmol/L, respectively. NT-proBNP correlated significantly with the determined parameters both in the group 1 and the group 2. In the group 1, the highest correlation was obtained with C-reactive protein (r = 0.8424). In the group 2, the highest correlation was obtained with ejection fraction (r = -0.9111). NT-proBNP showed progressive increase in proportion to the New York Heart Association (NYHA) classification. The patients in the- group 2 who belonged to the II and III NYHA class had significantly higher levels of NT-proBNP than those in the NYHA class I (ANOVA test,p = 0.001). Conclusion. The obtained results suggest that NT-proBNP is a useful biomarker in the treatment of patients with longstanding hypertension who are at risk for heart failure.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters in patients with hypertension",
volume = "70",
number = "8",
pages = "728-734",
doi = "10.2298/VSP110322048P"
}

Pejović, J., Ignjatović, S., Dajak, M., Majkić-Singh, N., Vučinić, Ž.,& Pavlović, M.. (2013). Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters in patients with hypertension. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 70(8), 728-734.
https://doi.org/10.2298/VSP110322048P

Pejović J, Ignjatović S, Dajak M, Majkić-Singh N, Vučinić Ž, Pavlović M. Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters in patients with hypertension. in Vojnosanitetski pregled. 2013;70(8):728-734.
doi:10.2298/VSP110322048P .

Pejović, Janko, Ignjatović, Svetlana, Dajak, Marijana, Majkić-Singh, Nada, Vučinić, Žarko, Pavlović, Miroslav, "Correlation of N-terminal pro-B-type natriuretic peptide with clinical parameters in patients with hypertension" in Vojnosanitetski pregled, 70, no. 8 (2013):728-734,
https://doi.org/10.2298/VSP110322048P . .

TY  - CONF
AU  - Lezaić, V
AU  - Mirković, Duško
AU  - Ristić, S.
AU  - Radivojević, Dragana
AU  - Dajak, Marijana
AU  - Naumović, Radomir
AU  - Đukanović, Ljubica
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1658
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Transplantation Proceedings
T1  - Potential Influence of Tubular Dysfunction in Agreement of Estimated and Measured Glomerular Fultration Rate after Kidney Transplantation
VL  - 94
IS  - 10
SP  - 873
EP  - 873
DO  - 10.1097/00007890-201211271-01718
ER  - 

@conference{
author = "Lezaić, V and Mirković, Duško and Ristić, S. and Radivojević, Dragana and Dajak, Marijana and Naumović, Radomir and Đukanović, Ljubica",
year = "2012",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Transplantation Proceedings",
title = "Potential Influence of Tubular Dysfunction in Agreement of Estimated and Measured Glomerular Fultration Rate after Kidney Transplantation",
volume = "94",
number = "10",
pages = "873-873",
doi = "10.1097/00007890-201211271-01718"
}

Lezaić, V., Mirković, D., Ristić, S., Radivojević, D., Dajak, M., Naumović, R.,& Đukanović, L.. (2012). Potential Influence of Tubular Dysfunction in Agreement of Estimated and Measured Glomerular Fultration Rate after Kidney Transplantation. in Transplantation Proceedings
Lippincott Williams & Wilkins, Philadelphia., 94(10), 873-873.
https://doi.org/10.1097/00007890-201211271-01718

Lezaić V, Mirković D, Ristić S, Radivojević D, Dajak M, Naumović R, Đukanović L. Potential Influence of Tubular Dysfunction in Agreement of Estimated and Measured Glomerular Fultration Rate after Kidney Transplantation. in Transplantation Proceedings. 2012;94(10):873-873.
doi:10.1097/00007890-201211271-01718 .

Lezaić, V, Mirković, Duško, Ristić, S., Radivojević, Dragana, Dajak, Marijana, Naumović, Radomir, Đukanović, Ljubica, "Potential Influence of Tubular Dysfunction in Agreement of Estimated and Measured Glomerular Fultration Rate after Kidney Transplantation" in Transplantation Proceedings, 94, no. 10 (2012):873-873,
https://doi.org/10.1097/00007890-201211271-01718 . .

TY  - JOUR
AU  - Dajak, Marijana
AU  - Bontić, Ana
AU  - Ignjatović, Svetlana
AU  - Pavlović, Jelena
AU  - Majkić-Singh, Nada
AU  - Lezaić, Višnja
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1747
AB  - Introduction One of the criteria for chronic kidney disease detection is determination of microalbuminuria. Objective This analysis was performed to evaluate accuracy of three useful methods for microalbuminuria detection in 24h urine collection and in the morning urine specimen calculated from urine albumin creatinine ratio, or with a dipstick in patients with different kidney diseases or kidney function. Methods Microalbuminuria was detected in 74 patients referred to the Outpatient Nephrology Department for kidney function determination or regular nephrology checking. Albumin concentration determined using immunonephelometry was lower than 300 mg/day. Discriminates cutoff values for spot urine test strip and albumin creatinin ratio in predicting 24 h protein 'threshold' excretion were determined using ROC analysis. Results Mean value of 24 h microalbuminuria was 80.3 mg/24 h, and value >30 mg/24 h was present in 71.8% of patient. Correlation coefficients between dipstick microalbuminuria or albumin/creatinine ratio in a spot urine specimen and 24 h microalbuminuria were 0.709 and 0.598 (p lt 0.0001). For pathological value of 24 h microalbuminuria >30 mg/24 h, the coresponding dipstick microalbuminuria value was >= 20 mg/L (AUC 0.849, specificity 95%, positive predictive value 97.3%), and >= 3.55 mg albumin/mmol creatinine ratio (AUC 0.914, specificity 90% and positive predictive value 95.5%). No difference was found between dipstick mikroalbuminuria and albumin/creatinine ratio value. In addition, albumin/creatinine ratio value from 24 h urine was similar to the value obtained from the spot urine sample. Conclusion Obtained results indicated that albuminuria could be determined accurately in spot urine either with the Micral test strip or with albumin creatinine ratio.
PB  - Srpsko lekarsko društvo, Beograd
T2  - Srpski arhiv za celokupno lekarstvo
T1  - Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients
VL  - 140
IS  - 3-4
SP  - 173
EP  - 178
DO  - 10.2298/SARH1204173D
ER  - 

@article{
author = "Dajak, Marijana and Bontić, Ana and Ignjatović, Svetlana and Pavlović, Jelena and Majkić-Singh, Nada and Lezaić, Višnja",
year = "2012",
abstract = "Introduction One of the criteria for chronic kidney disease detection is determination of microalbuminuria. Objective This analysis was performed to evaluate accuracy of three useful methods for microalbuminuria detection in 24h urine collection and in the morning urine specimen calculated from urine albumin creatinine ratio, or with a dipstick in patients with different kidney diseases or kidney function. Methods Microalbuminuria was detected in 74 patients referred to the Outpatient Nephrology Department for kidney function determination or regular nephrology checking. Albumin concentration determined using immunonephelometry was lower than 300 mg/day. Discriminates cutoff values for spot urine test strip and albumin creatinin ratio in predicting 24 h protein 'threshold' excretion were determined using ROC analysis. Results Mean value of 24 h microalbuminuria was 80.3 mg/24 h, and value >30 mg/24 h was present in 71.8% of patient. Correlation coefficients between dipstick microalbuminuria or albumin/creatinine ratio in a spot urine specimen and 24 h microalbuminuria were 0.709 and 0.598 (p lt 0.0001). For pathological value of 24 h microalbuminuria >30 mg/24 h, the coresponding dipstick microalbuminuria value was >= 20 mg/L (AUC 0.849, specificity 95%, positive predictive value 97.3%), and >= 3.55 mg albumin/mmol creatinine ratio (AUC 0.914, specificity 90% and positive predictive value 95.5%). No difference was found between dipstick mikroalbuminuria and albumin/creatinine ratio value. In addition, albumin/creatinine ratio value from 24 h urine was similar to the value obtained from the spot urine sample. Conclusion Obtained results indicated that albuminuria could be determined accurately in spot urine either with the Micral test strip or with albumin creatinine ratio.",
publisher = "Srpsko lekarsko društvo, Beograd",
journal = "Srpski arhiv za celokupno lekarstvo",
title = "Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients",
volume = "140",
number = "3-4",
pages = "173-178",
doi = "10.2298/SARH1204173D"
}

Dajak, M., Bontić, A., Ignjatović, S., Pavlović, J., Majkić-Singh, N.,& Lezaić, V.. (2012). Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients. in Srpski arhiv za celokupno lekarstvo
Srpsko lekarsko društvo, Beograd., 140(3-4), 173-178.
https://doi.org/10.2298/SARH1204173D

Dajak M, Bontić A, Ignjatović S, Pavlović J, Majkić-Singh N, Lezaić V. Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients. in Srpski arhiv za celokupno lekarstvo. 2012;140(3-4):173-178.
doi:10.2298/SARH1204173D .

Dajak, Marijana, Bontić, Ana, Ignjatović, Svetlana, Pavlović, Jelena, Majkić-Singh, Nada, Lezaić, Višnja, "Evaluation of Methods for Rapid Microalbuminuria Screening in Kidney Diseased Patients" in Srpski arhiv za celokupno lekarstvo, 140, no. 3-4 (2012):173-178,
https://doi.org/10.2298/SARH1204173D . .

TY  - JOUR
AU  - Pejović, Janko
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Majkić-Singh, Nada
AU  - Vučinić, Žarko
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1557
AB  - Patients with hypertensive heart disease have elevated concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP). The aim of our study was to evaluate NT-proBNP in patients with long-standing hypertension and in patients with signs of hypertensive cardiomyopathy. The study included three groups of 50 subjects: healthy persons (Control Group), patients with hypertension and normal left ventricular systolic function (Group 1) and patients with long-standing hypertension and signs of hypertensive cardiomyopathy with impaired left ventricular systolic function (Group 2). Our results show a very good correlation (Pearson's test) between NT-proBNP in Group 1 and Group 2 and C-reactive protein (Group 1: r = 0.8424; Group 2: r = 0.6650), systolic blood pressure (Group 1: r = 0.7213; Group 2: r = 0.4856), diastolic blood pressure (Group 1: r = 0.4282; Group 2: r = 0.3989) and ejection fraction (Group 1: r = -0.7390; Group 2: r = 0.9111). ROC analysis revealed that the AUC between the Control Group and Group 1 for NT-proBNP (0.912) was not significantly different (p>0.05) from the AUC for systolic (0.924) and diastolic pressure (0.937). A cut-off value for NT-proBNP of 5.89 pmol/L can be used to reliably distinguish patients of Group 1 from the Control Group, and a cut-off value of 21.67 pmol/L reliably separates patients from Group 1 and Group 2 (in both cases, the AUC is 1.000). Patients in Group 2 who belonged to the II and III New York Heart Association (NYHA) class had significantly higher levels of NT-proBNP than those in NYHA class I (ANOVA test, p=0.001). These data suggest that NT-proBNP is a useful biomarker for distinguishing patients with long-standing hypertension who are at risk of heart failure, allowing optimization and proper treatment of these patients.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - N-terminal pro-b-type natriuretic peptide in patients with hypertensive heart disease
VL  - 30
IS  - 3
SP  - 244
EP  - 249
DO  - 10.2478/v10011-011-0016-4
ER  - 

@article{
author = "Pejović, Janko and Ignjatović, Svetlana and Dajak, Marijana and Majkić-Singh, Nada and Vučinić, Žarko",
year = "2011",
abstract = "Patients with hypertensive heart disease have elevated concentrations of N-terminal pro-B-type natriuretic peptide (NT-proBNP). The aim of our study was to evaluate NT-proBNP in patients with long-standing hypertension and in patients with signs of hypertensive cardiomyopathy. The study included three groups of 50 subjects: healthy persons (Control Group), patients with hypertension and normal left ventricular systolic function (Group 1) and patients with long-standing hypertension and signs of hypertensive cardiomyopathy with impaired left ventricular systolic function (Group 2). Our results show a very good correlation (Pearson's test) between NT-proBNP in Group 1 and Group 2 and C-reactive protein (Group 1: r = 0.8424; Group 2: r = 0.6650), systolic blood pressure (Group 1: r = 0.7213; Group 2: r = 0.4856), diastolic blood pressure (Group 1: r = 0.4282; Group 2: r = 0.3989) and ejection fraction (Group 1: r = -0.7390; Group 2: r = 0.9111). ROC analysis revealed that the AUC between the Control Group and Group 1 for NT-proBNP (0.912) was not significantly different (p>0.05) from the AUC for systolic (0.924) and diastolic pressure (0.937). A cut-off value for NT-proBNP of 5.89 pmol/L can be used to reliably distinguish patients of Group 1 from the Control Group, and a cut-off value of 21.67 pmol/L reliably separates patients from Group 1 and Group 2 (in both cases, the AUC is 1.000). Patients in Group 2 who belonged to the II and III New York Heart Association (NYHA) class had significantly higher levels of NT-proBNP than those in NYHA class I (ANOVA test, p=0.001). These data suggest that NT-proBNP is a useful biomarker for distinguishing patients with long-standing hypertension who are at risk of heart failure, allowing optimization and proper treatment of these patients.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "N-terminal pro-b-type natriuretic peptide in patients with hypertensive heart disease",
volume = "30",
number = "3",
pages = "244-249",
doi = "10.2478/v10011-011-0016-4"
}

Pejović, J., Ignjatović, S., Dajak, M., Majkić-Singh, N.,& Vučinić, Ž.. (2011). N-terminal pro-b-type natriuretic peptide in patients with hypertensive heart disease. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 30(3), 244-249.
https://doi.org/10.2478/v10011-011-0016-4

Pejović J, Ignjatović S, Dajak M, Majkić-Singh N, Vučinić Ž. N-terminal pro-b-type natriuretic peptide in patients with hypertensive heart disease. in Journal of Medical Biochemistry. 2011;30(3):244-249.
doi:10.2478/v10011-011-0016-4 .

Pejović, Janko, Ignjatović, Svetlana, Dajak, Marijana, Majkić-Singh, Nada, Vučinić, Žarko, "N-terminal pro-b-type natriuretic peptide in patients with hypertensive heart disease" in Journal of Medical Biochemistry, 30, no. 3 (2011):244-249,
https://doi.org/10.2478/v10011-011-0016-4 . .

TY  - JOUR
AU  - Šumarac, Zorica
AU  - Suvajdzić, Nada
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
AU  - Janić, Dragana
AU  - Petakov, Milan
AU  - Đorđević, Maja
AU  - Mitrović, Mirjana
AU  - Dajak, Marijana
AU  - Golubović, Milka
AU  - Rodić, Predrag
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1553
AB  - Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Biomarkers in Serbian patients with Gaucher disease
VL  - 44
IS  - 12
SP  - 950
EP  - 954
DO  - 10.1016/j.clinbiochem.2011.05.016
ER  - 

@article{
author = "Šumarac, Zorica and Suvajdzić, Nada and Ignjatović, Svetlana and Majkić-Singh, Nada and Janić, Dragana and Petakov, Milan and Đorđević, Maja and Mitrović, Mirjana and Dajak, Marijana and Golubović, Milka and Rodić, Predrag",
year = "2011",
abstract = "Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Biomarkers in Serbian patients with Gaucher disease",
volume = "44",
number = "12",
pages = "950-954",
doi = "10.1016/j.clinbiochem.2011.05.016"
}

Šumarac, Z., Suvajdzić, N., Ignjatović, S., Majkić-Singh, N., Janić, D., Petakov, M., Đorđević, M., Mitrović, M., Dajak, M., Golubović, M.,& Rodić, P.. (2011). Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 44(12), 950-954.
https://doi.org/10.1016/j.clinbiochem.2011.05.016

Šumarac Z, Suvajdzić N, Ignjatović S, Majkić-Singh N, Janić D, Petakov M, Đorđević M, Mitrović M, Dajak M, Golubović M, Rodić P. Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry. 2011;44(12):950-954.
doi:10.1016/j.clinbiochem.2011.05.016 .

Šumarac, Zorica, Suvajdzić, Nada, Ignjatović, Svetlana, Majkić-Singh, Nada, Janić, Dragana, Petakov, Milan, Đorđević, Maja, Mitrović, Mirjana, Dajak, Marijana, Golubović, Milka, Rodić, Predrag, "Biomarkers in Serbian patients with Gaucher disease" in Clinical Biochemistry, 44, no. 12 (2011):950-954,
https://doi.org/10.1016/j.clinbiochem.2011.05.016 . .

TY  - CONF
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
AU  - Stojimirović, Biljana
AU  - Majkić-Singh, Nada
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1529
PB  - Walter de Gruyter & Co, Berlin
C3  - Clinical Chemistry and Laboratory Medicine
T1  - Urinary proteins as biomarkers of chronic kidney injury
VL  - 49
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1529
ER  - 

@conference{
author = "Dajak, Marijana and Ignjatović, Svetlana and Stojimirović, Biljana and Majkić-Singh, Nada",
year = "2011",
publisher = "Walter de Gruyter & Co, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Urinary proteins as biomarkers of chronic kidney injury",
volume = "49",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1529"
}

Dajak, M., Ignjatović, S., Stojimirović, B.,& Majkić-Singh, N.. (2011). Urinary proteins as biomarkers of chronic kidney injury. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter & Co, Berlin., 49.
https://hdl.handle.net/21.15107/rcub_farfar_1529

Dajak M, Ignjatović S, Stojimirović B, Majkić-Singh N. Urinary proteins as biomarkers of chronic kidney injury. in Clinical Chemistry and Laboratory Medicine. 2011;49.
https://hdl.handle.net/21.15107/rcub_farfar_1529 .

Dajak, Marijana, Ignjatović, Svetlana, Stojimirović, Biljana, Majkić-Singh, Nada, "Urinary proteins as biomarkers of chronic kidney injury" in Clinical Chemistry and Laboratory Medicine, 49 (2011),
https://hdl.handle.net/21.15107/rcub_farfar_1529 .

TY  - CONF
AU  - Kangrga, Ranka
AU  - Dajak, Marijana
AU  - Dragasević, M.
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1528
PB  - Walter de Gruyter & Co, Berlin
C3  - Clinical Chemistry and Laboratory Medicine
T1  - Faecal elastase 1 levels as a marker of exocrine pancreatic function in patients with diabetes mellitus
VL  - 49
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1528
ER  - 

@conference{
author = "Kangrga, Ranka and Dajak, Marijana and Dragasević, M. and Ignjatović, Svetlana and Majkić-Singh, Nada",
year = "2011",
publisher = "Walter de Gruyter & Co, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Faecal elastase 1 levels as a marker of exocrine pancreatic function in patients with diabetes mellitus",
volume = "49",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1528"
}

Kangrga, R., Dajak, M., Dragasević, M., Ignjatović, S.,& Majkić-Singh, N.. (2011). Faecal elastase 1 levels as a marker of exocrine pancreatic function in patients with diabetes mellitus. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter & Co, Berlin., 49.
https://hdl.handle.net/21.15107/rcub_farfar_1528

Kangrga R, Dajak M, Dragasević M, Ignjatović S, Majkić-Singh N. Faecal elastase 1 levels as a marker of exocrine pancreatic function in patients with diabetes mellitus. in Clinical Chemistry and Laboratory Medicine. 2011;49.
https://hdl.handle.net/21.15107/rcub_farfar_1528 .

Kangrga, Ranka, Dajak, Marijana, Dragasević, M., Ignjatović, Svetlana, Majkić-Singh, Nada, "Faecal elastase 1 levels as a marker of exocrine pancreatic function in patients with diabetes mellitus" in Clinical Chemistry and Laboratory Medicine, 49 (2011),
https://hdl.handle.net/21.15107/rcub_farfar_1528 .

TY  - JOUR
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
AU  - Stojimirović, Biljana
AU  - Gajić, Snežana
AU  - Majkić-Singh, Nada
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1499
AB  - Background: Beta-trace protein (BTP) was found to be increased in the serum and urine of patients with renal diseases. The aim of this study was to compare the urinary levels of beta-trace protein with levels of other urinary proteins: albumin, beta(2)-microglobulin (B2M), alpha(1)-microglobulin (A1M), and cystatin C and to determine its clinical usefulness for detection of renal dysfunction in chronic kidney disease (CKD). Methods: These markers were measured in 24-hour urine samples from 134 patients with CKD. Results: BTP correlated significantly with A1M (r = 0.871), cystatin C (r = 0.759), total protein (r = 0.684), B2M (r = 0.497), and albumin (r = 0.448) in 24-hour urine samples (P  lt  0.05). Urinary BTP concentrations in patients with albuminuria below 30 mg / day were significantly lower than in patients with albuminuria above 30 mg / day (P  lt  0.0001). ROC analysis showed high diagnostic accuracy of BTP for detection of > 30 mg / day albuminuria (AUC 0.908). Urinary BTP was also in significant correlation with the estimated glomerular filtration rate (r = -0.580). Conclusions: The results of our study suggest that BTP may be a useful and reliable urinary marker of renal dysfunction and may have a place in addition to urinary alpha(1)-microglobulin and albumin as an alternative marker for tubular damage and the magnitude of renal impairment in patients with chronic kidney disease. (Clin. Lab. 2011;57:29-36)
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - Evaluation of Renal Damage by Urinary Beta-Trace Protein in Patients with Chronic Kidney Disease
VL  - 57
IS  - 1-2
SP  - 29
EP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1499
ER  - 

@article{
author = "Dajak, Marijana and Ignjatović, Svetlana and Stojimirović, Biljana and Gajić, Snežana and Majkić-Singh, Nada",
year = "2011",
abstract = "Background: Beta-trace protein (BTP) was found to be increased in the serum and urine of patients with renal diseases. The aim of this study was to compare the urinary levels of beta-trace protein with levels of other urinary proteins: albumin, beta(2)-microglobulin (B2M), alpha(1)-microglobulin (A1M), and cystatin C and to determine its clinical usefulness for detection of renal dysfunction in chronic kidney disease (CKD). Methods: These markers were measured in 24-hour urine samples from 134 patients with CKD. Results: BTP correlated significantly with A1M (r = 0.871), cystatin C (r = 0.759), total protein (r = 0.684), B2M (r = 0.497), and albumin (r = 0.448) in 24-hour urine samples (P  lt  0.05). Urinary BTP concentrations in patients with albuminuria below 30 mg / day were significantly lower than in patients with albuminuria above 30 mg / day (P  lt  0.0001). ROC analysis showed high diagnostic accuracy of BTP for detection of > 30 mg / day albuminuria (AUC 0.908). Urinary BTP was also in significant correlation with the estimated glomerular filtration rate (r = -0.580). Conclusions: The results of our study suggest that BTP may be a useful and reliable urinary marker of renal dysfunction and may have a place in addition to urinary alpha(1)-microglobulin and albumin as an alternative marker for tubular damage and the magnitude of renal impairment in patients with chronic kidney disease. (Clin. Lab. 2011;57:29-36)",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "Evaluation of Renal Damage by Urinary Beta-Trace Protein in Patients with Chronic Kidney Disease",
volume = "57",
number = "1-2",
pages = "29-36",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1499"
}

Dajak, M., Ignjatović, S., Stojimirović, B., Gajić, S.,& Majkić-Singh, N.. (2011). Evaluation of Renal Damage by Urinary Beta-Trace Protein in Patients with Chronic Kidney Disease. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 57(1-2), 29-36.
https://hdl.handle.net/21.15107/rcub_farfar_1499

Dajak M, Ignjatović S, Stojimirović B, Gajić S, Majkić-Singh N. Evaluation of Renal Damage by Urinary Beta-Trace Protein in Patients with Chronic Kidney Disease. in Clinical Laboratory. 2011;57(1-2):29-36.
https://hdl.handle.net/21.15107/rcub_farfar_1499 .

Dajak, Marijana, Ignjatović, Svetlana, Stojimirović, Biljana, Gajić, Snežana, Majkić-Singh, Nada, "Evaluation of Renal Damage by Urinary Beta-Trace Protein in Patients with Chronic Kidney Disease" in Clinical Laboratory, 57, no. 1-2 (2011):29-36,
https://hdl.handle.net/21.15107/rcub_farfar_1499 .

TY  - JOUR
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
AU  - Stojimirović, Biljana
AU  - Gajić, Snežana
AU  - Majkić-Singh, Nada
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1400
PB  - Elsevier Science BV, Amsterdam
T2  - Clinica Chimica Acta
T1  - Urinary beta-trace protein as a tubular marker of renal dysfunction in patients with chronic kidney disease
VL  - 411
IS  - 15-16
SP  - 1154
EP  - 1155
DO  - 10.1016/j.cca.2010.04.013
ER  - 

@article{
author = "Dajak, Marijana and Ignjatović, Svetlana and Stojimirović, Biljana and Gajić, Snežana and Majkić-Singh, Nada",
year = "2010",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Clinica Chimica Acta",
title = "Urinary beta-trace protein as a tubular marker of renal dysfunction in patients with chronic kidney disease",
volume = "411",
number = "15-16",
pages = "1154-1155",
doi = "10.1016/j.cca.2010.04.013"
}

Dajak, M., Ignjatović, S., Stojimirović, B., Gajić, S.,& Majkić-Singh, N.. (2010). Urinary beta-trace protein as a tubular marker of renal dysfunction in patients with chronic kidney disease. in Clinica Chimica Acta
Elsevier Science BV, Amsterdam., 411(15-16), 1154-1155.
https://doi.org/10.1016/j.cca.2010.04.013

Dajak M, Ignjatović S, Stojimirović B, Gajić S, Majkić-Singh N. Urinary beta-trace protein as a tubular marker of renal dysfunction in patients with chronic kidney disease. in Clinica Chimica Acta. 2010;411(15-16):1154-1155.
doi:10.1016/j.cca.2010.04.013 .

Dajak, Marijana, Ignjatović, Svetlana, Stojimirović, Biljana, Gajić, Snežana, Majkić-Singh, Nada, "Urinary beta-trace protein as a tubular marker of renal dysfunction in patients with chronic kidney disease" in Clinica Chimica Acta, 411, no. 15-16 (2010):1154-1155,
https://doi.org/10.1016/j.cca.2010.04.013 . .

TY  - JOUR
AU  - Marković, Mirjana
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Majkić-Singh, Nada
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1412
AB  - Background: Placental growth factor (PlGF) belongs to the vascular endothelial growth factor family and seems to be an independent biomarker for plaque disruption, ischemia, and thrombosis. Plasma PlGF is rapidly produced in infarcted myocardial tissue during the acute phase of myocardial infarction. In this study, the relevance of PIGF was analyzed at the admission of patients with acute coronary syndrome (ACS) without ST elevation for the prognosis of fatal outcome after 30 days. Methods: We collected blood samples from 102 ACS patients admitted to the coronary unit with manifesting acute chest pain within the previous 12 hours and measured the levels of PIGF, high-sensitivity C-reactive protein (hsCRP), and cardiac markers: troponin T (cTnT), B-type natriuretic peptide, creatine kinase-MB (CKMB) and CK activity. Results: PlGF, troponin T, and hsCRP levels were significantly higher in non-survivors than in survivors. ROC analysis showed that PIGF had the highest area under ROC curve (AUC, 0.713), but it was not significantly different from AUCs for cTnT and hsCRP. Higher values of PlGF (>13.2 ng/L) pointed towards a higher risk of fatal outcome (HR 2.28; 95 % CI 1.21-4.76; P=0.0125). The multivariable proportional hazards analysis, which had involved other statistically significant markers of relative risk (age and gender), showed that PlGF was an independent prognostic marker (adjusted HR 2.14; 95 % CI 1.08-4.22). Conclusions: These results confirmed that PlGF is an independent biomarker of short-term adverse outcome in patients with ACS without ST elevation and that plaque instability, represented by PlGF elevation, has an important role in the pathogenesis of future coronary events. (Clin. Lab. 2010;56:215-222)
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - Utility of Placental Growth Factor for Prediction of 30-Day Adverse Event in Emergency Department Population with Non-ST Elevation Acute Coronary Syndrome
VL  - 56
IS  - 5-6
SP  - 215
EP  - 222
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1412
ER  - 

@article{
author = "Marković, Mirjana and Ignjatović, Svetlana and Dajak, Marijana and Majkić-Singh, Nada",
year = "2010",
abstract = "Background: Placental growth factor (PlGF) belongs to the vascular endothelial growth factor family and seems to be an independent biomarker for plaque disruption, ischemia, and thrombosis. Plasma PlGF is rapidly produced in infarcted myocardial tissue during the acute phase of myocardial infarction. In this study, the relevance of PIGF was analyzed at the admission of patients with acute coronary syndrome (ACS) without ST elevation for the prognosis of fatal outcome after 30 days. Methods: We collected blood samples from 102 ACS patients admitted to the coronary unit with manifesting acute chest pain within the previous 12 hours and measured the levels of PIGF, high-sensitivity C-reactive protein (hsCRP), and cardiac markers: troponin T (cTnT), B-type natriuretic peptide, creatine kinase-MB (CKMB) and CK activity. Results: PlGF, troponin T, and hsCRP levels were significantly higher in non-survivors than in survivors. ROC analysis showed that PIGF had the highest area under ROC curve (AUC, 0.713), but it was not significantly different from AUCs for cTnT and hsCRP. Higher values of PlGF (>13.2 ng/L) pointed towards a higher risk of fatal outcome (HR 2.28; 95 % CI 1.21-4.76; P=0.0125). The multivariable proportional hazards analysis, which had involved other statistically significant markers of relative risk (age and gender), showed that PlGF was an independent prognostic marker (adjusted HR 2.14; 95 % CI 1.08-4.22). Conclusions: These results confirmed that PlGF is an independent biomarker of short-term adverse outcome in patients with ACS without ST elevation and that plaque instability, represented by PlGF elevation, has an important role in the pathogenesis of future coronary events. (Clin. Lab. 2010;56:215-222)",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "Utility of Placental Growth Factor for Prediction of 30-Day Adverse Event in Emergency Department Population with Non-ST Elevation Acute Coronary Syndrome",
volume = "56",
number = "5-6",
pages = "215-222",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1412"
}

Marković, M., Ignjatović, S., Dajak, M.,& Majkić-Singh, N.. (2010). Utility of Placental Growth Factor for Prediction of 30-Day Adverse Event in Emergency Department Population with Non-ST Elevation Acute Coronary Syndrome. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 56(5-6), 215-222.
https://hdl.handle.net/21.15107/rcub_farfar_1412

Marković M, Ignjatović S, Dajak M, Majkić-Singh N. Utility of Placental Growth Factor for Prediction of 30-Day Adverse Event in Emergency Department Population with Non-ST Elevation Acute Coronary Syndrome. in Clinical Laboratory. 2010;56(5-6):215-222.
https://hdl.handle.net/21.15107/rcub_farfar_1412 .

Marković, Mirjana, Ignjatović, Svetlana, Dajak, Marijana, Majkić-Singh, Nada, "Utility of Placental Growth Factor for Prediction of 30-Day Adverse Event in Emergency Department Population with Non-ST Elevation Acute Coronary Syndrome" in Clinical Laboratory, 56, no. 5-6 (2010):215-222,
https://hdl.handle.net/21.15107/rcub_farfar_1412 .

TY  - JOUR
AU  - Marković, Mirjana
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Majkić-Singh, Nada
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1362
AB  - Objectives: The relevance of placental growth factor was analyzed at the admission of patients with acute coronary syndrome (ACS) without ST elevation in prognosis of fatal outcome after 30 days. Methods: We collected blood samples from 102 ACS patients admitted to the coronary unit with acute chest pain manifesting within the last 12 hours. Results: In all 102 admitted patients, higher values of placental growth factor (PLGF; >13.2 ng/L, average value) indicated a higher risk of fatal outcome (hazard ratio [HR] 2.28, 95% confidence interval [CI] 1.21-4.76, P = 0.0125). PLGF is an important independent prognostic marker (adjusted HR 2.35, 95% CI 1.98-4.61, P = 0.1338), and this was shown in a multiparameter model, which involved other statistically important markers of relative risk (age >65, gender, and estimated glomerular filtration rate [eGFR]). Conclusion: PLGF levels measured at 12 hours of symptom onset and 30 days later may independently predict fatal outcome in patients with ACS without ST elevation.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
T1  - Placental Growth Factor as Short-Term Predicting Biomarker in Acute Coronary Syndrome Patients with Non-ST Elevation Myocardial Infarction
VL  - 103
IS  - 10
SP  - 982
EP  - 987
DO  - 10.1097/SMJ.0b013e3181eda4ef
ER  - 

@article{
author = "Marković, Mirjana and Ignjatović, Svetlana and Dajak, Marijana and Majkić-Singh, Nada",
year = "2010",
abstract = "Objectives: The relevance of placental growth factor was analyzed at the admission of patients with acute coronary syndrome (ACS) without ST elevation in prognosis of fatal outcome after 30 days. Methods: We collected blood samples from 102 ACS patients admitted to the coronary unit with acute chest pain manifesting within the last 12 hours. Results: In all 102 admitted patients, higher values of placental growth factor (PLGF; >13.2 ng/L, average value) indicated a higher risk of fatal outcome (hazard ratio [HR] 2.28, 95% confidence interval [CI] 1.21-4.76, P = 0.0125). PLGF is an important independent prognostic marker (adjusted HR 2.35, 95% CI 1.98-4.61, P = 0.1338), and this was shown in a multiparameter model, which involved other statistically important markers of relative risk (age >65, gender, and estimated glomerular filtration rate [eGFR]). Conclusion: PLGF levels measured at 12 hours of symptom onset and 30 days later may independently predict fatal outcome in patients with ACS without ST elevation.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy",
title = "Placental Growth Factor as Short-Term Predicting Biomarker in Acute Coronary Syndrome Patients with Non-ST Elevation Myocardial Infarction",
volume = "103",
number = "10",
pages = "982-987",
doi = "10.1097/SMJ.0b013e3181eda4ef"
}

Marković, M., Ignjatović, S., Dajak, M.,& Majkić-Singh, N.. (2010). Placental Growth Factor as Short-Term Predicting Biomarker in Acute Coronary Syndrome Patients with Non-ST Elevation Myocardial Infarction. in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Lippincott Williams & Wilkins, Philadelphia., 103(10), 982-987.
https://doi.org/10.1097/SMJ.0b013e3181eda4ef

Marković M, Ignjatović S, Dajak M, Majkić-Singh N. Placental Growth Factor as Short-Term Predicting Biomarker in Acute Coronary Syndrome Patients with Non-ST Elevation Myocardial Infarction. in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2010;103(10):982-987.
doi:10.1097/SMJ.0b013e3181eda4ef .

Marković, Mirjana, Ignjatović, Svetlana, Dajak, Marijana, Majkić-Singh, Nada, "Placental Growth Factor as Short-Term Predicting Biomarker in Acute Coronary Syndrome Patients with Non-ST Elevation Myocardial Infarction" in Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 103, no. 10 (2010):982-987,
https://doi.org/10.1097/SMJ.0b013e3181eda4ef . .

TY  - JOUR
AU  - Marković, Mirjana
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
AU  - Dajak, Marijana
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1165
AB  - Background: Markers of plaque instability are considered as predictors of future events in patients with non ST-elevation myocardial infarction (NSTEMI) in acute coronary syndrome (ACS). The aim of this was to determine the role of placental growth factor (PIGF) as a possible: predictor of future coronary events such as non-fatal myocardial infarction or cardiac death measured at the admission and 30 days, after discharge. Methods: We prospectively collected data from 102 patients admitted to the emergency department (ED) for ACS with chest pain at rest within the preceding 12 hours who were evaluated by risk factors and electrocardiogram changes (ECG). Results: The time course of PIGF levels. determined on 102 patients showed a mean. value 13.21 ng/L and standard deviation 8.76 ng/L but in the sample of the 53 patients who survived after 30 days, these values decreased to 10.48 ng/L and 5.45 ng/L, respectively, Conclusions: Results of this study indicate a clinically useful role of PIGF in the detection of ACS and NSTEMI patients who are at a higher risk for different cardiovascular disorders within 30 days of admission.
PB  - Amer Soc Clinical Pathology, Chicago
T2  - Labmedicine
T1  - Placental Growth Factor in Acute Coronary Syndrome Patients with Non ST-Elevation
VL  - 40
IS  - 11
SP  - 675
EP  - 678
DO  - 10.1309/LMK6X47RSYRCGCSB
ER  - 

@article{
author = "Marković, Mirjana and Ignjatović, Svetlana and Majkić-Singh, Nada and Dajak, Marijana",
year = "2009",
abstract = "Background: Markers of plaque instability are considered as predictors of future events in patients with non ST-elevation myocardial infarction (NSTEMI) in acute coronary syndrome (ACS). The aim of this was to determine the role of placental growth factor (PIGF) as a possible: predictor of future coronary events such as non-fatal myocardial infarction or cardiac death measured at the admission and 30 days, after discharge. Methods: We prospectively collected data from 102 patients admitted to the emergency department (ED) for ACS with chest pain at rest within the preceding 12 hours who were evaluated by risk factors and electrocardiogram changes (ECG). Results: The time course of PIGF levels. determined on 102 patients showed a mean. value 13.21 ng/L and standard deviation 8.76 ng/L but in the sample of the 53 patients who survived after 30 days, these values decreased to 10.48 ng/L and 5.45 ng/L, respectively, Conclusions: Results of this study indicate a clinically useful role of PIGF in the detection of ACS and NSTEMI patients who are at a higher risk for different cardiovascular disorders within 30 days of admission.",
publisher = "Amer Soc Clinical Pathology, Chicago",
journal = "Labmedicine",
title = "Placental Growth Factor in Acute Coronary Syndrome Patients with Non ST-Elevation",
volume = "40",
number = "11",
pages = "675-678",
doi = "10.1309/LMK6X47RSYRCGCSB"
}

Marković, M., Ignjatović, S., Majkić-Singh, N.,& Dajak, M.. (2009). Placental Growth Factor in Acute Coronary Syndrome Patients with Non ST-Elevation. in Labmedicine
Amer Soc Clinical Pathology, Chicago., 40(11), 675-678.
https://doi.org/10.1309/LMK6X47RSYRCGCSB

Marković M, Ignjatović S, Majkić-Singh N, Dajak M. Placental Growth Factor in Acute Coronary Syndrome Patients with Non ST-Elevation. in Labmedicine. 2009;40(11):675-678.
doi:10.1309/LMK6X47RSYRCGCSB .

Marković, Mirjana, Ignjatović, Svetlana, Majkić-Singh, Nada, Dajak, Marijana, "Placental Growth Factor in Acute Coronary Syndrome Patients with Non ST-Elevation" in Labmedicine, 40, no. 11 (2009):675-678,
https://doi.org/10.1309/LMK6X47RSYRCGCSB . .

TY  - JOUR
AU  - Jovičić, Snežana
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Kangrga, Ranka
AU  - Majkić-Singh, Nada
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1198
AB  - Background: High-sensitivity C-reactive protein (hsCRP) has been recognized as an independent marker of cardiovascular risk. Since atherosclerosis is a multifactorial disease, the aim of this study was to determine association between hsCRP and other markers of inflammation and dyslipidemia. Materials and Methods: In 242 healthy volunteers, total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), nonHDL-C, triglycerides (TG) and hsCRP were measured using Olympus AU2700. Apolipoprotein A-1 (apoA1), apolipoprotein B (apo B), lipoprotein (a) (Lp(a)), haptoglobin, alpha(1)-acid glycoprotein (A1AGP), C3 and C4 complement components were determined on Architect c8000, and serum amyloid A (SAA) and fibrinogen on BN II nephelometer and ACL 7000, respectively. Results: Significant (P  lt  0.05) partial Pearson's correlation coefficients were found between hsCRP and TC (r = 0.172), nonHDL-C (r = 0.182), LDL-C (r = 0.154), apoB (r = 0.167), fibrinogen (r = 0.411), SAA (r = 0.493), A1AGP (r = 0.462), haptoglobin (r = 0.310), C3 (r = 0.349) and C4 (r = 0.371). In multiple regression analysis, BMI, SAA, A1AGP, fibrinogen and nonHDL-C showed independent correlation with hsCRP. Multinomial logistic regression analysis demonstrated that BMI, nonHDL, fibrinogen and SAA were strong predictors of hsCRP concentration. Odds ratios for intermediate and high risk categories compared with the low risk category were 1.177 (1.033-1.341) and 1.289 (1.091-1.523), 1.515 (1.021-2.249) and 2.062 (1.246-3.411), 2.241 (1.268-3.959) and 7.123 (3.259-15.568), and 1.387 (1.179-1.632) and 1.691 (1.397-2.047), for BMI, nonHDL-C, fibrinogen and SAA, respectively. Conclusion: The prediction of risk for future cardiac events based on hsCRP concentration, which is the recommended parameter for improving cardiovascular risk stratification, might be complemented with the information about BMI, nonHDL-C, fibrinogen and SAA. (Clin. Lab. 2009;55:411-419)
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - Association of Lipid and Inflammatory Markers with C-Reactive Protein in Cardiovascular Risk Assessment for Primary Prevention
VL  - 55
IS  - 11-12
SP  - 411
EP  - 419
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1198
ER  - 

@article{
author = "Jovičić, Snežana and Ignjatović, Svetlana and Dajak, Marijana and Kangrga, Ranka and Majkić-Singh, Nada",
year = "2009",
abstract = "Background: High-sensitivity C-reactive protein (hsCRP) has been recognized as an independent marker of cardiovascular risk. Since atherosclerosis is a multifactorial disease, the aim of this study was to determine association between hsCRP and other markers of inflammation and dyslipidemia. Materials and Methods: In 242 healthy volunteers, total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), nonHDL-C, triglycerides (TG) and hsCRP were measured using Olympus AU2700. Apolipoprotein A-1 (apoA1), apolipoprotein B (apo B), lipoprotein (a) (Lp(a)), haptoglobin, alpha(1)-acid glycoprotein (A1AGP), C3 and C4 complement components were determined on Architect c8000, and serum amyloid A (SAA) and fibrinogen on BN II nephelometer and ACL 7000, respectively. Results: Significant (P  lt  0.05) partial Pearson's correlation coefficients were found between hsCRP and TC (r = 0.172), nonHDL-C (r = 0.182), LDL-C (r = 0.154), apoB (r = 0.167), fibrinogen (r = 0.411), SAA (r = 0.493), A1AGP (r = 0.462), haptoglobin (r = 0.310), C3 (r = 0.349) and C4 (r = 0.371). In multiple regression analysis, BMI, SAA, A1AGP, fibrinogen and nonHDL-C showed independent correlation with hsCRP. Multinomial logistic regression analysis demonstrated that BMI, nonHDL, fibrinogen and SAA were strong predictors of hsCRP concentration. Odds ratios for intermediate and high risk categories compared with the low risk category were 1.177 (1.033-1.341) and 1.289 (1.091-1.523), 1.515 (1.021-2.249) and 2.062 (1.246-3.411), 2.241 (1.268-3.959) and 7.123 (3.259-15.568), and 1.387 (1.179-1.632) and 1.691 (1.397-2.047), for BMI, nonHDL-C, fibrinogen and SAA, respectively. Conclusion: The prediction of risk for future cardiac events based on hsCRP concentration, which is the recommended parameter for improving cardiovascular risk stratification, might be complemented with the information about BMI, nonHDL-C, fibrinogen and SAA. (Clin. Lab. 2009;55:411-419)",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "Association of Lipid and Inflammatory Markers with C-Reactive Protein in Cardiovascular Risk Assessment for Primary Prevention",
volume = "55",
number = "11-12",
pages = "411-419",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1198"
}

Jovičić, S., Ignjatović, S., Dajak, M., Kangrga, R.,& Majkić-Singh, N.. (2009). Association of Lipid and Inflammatory Markers with C-Reactive Protein in Cardiovascular Risk Assessment for Primary Prevention. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 55(11-12), 411-419.
https://hdl.handle.net/21.15107/rcub_farfar_1198

Jovičić S, Ignjatović S, Dajak M, Kangrga R, Majkić-Singh N. Association of Lipid and Inflammatory Markers with C-Reactive Protein in Cardiovascular Risk Assessment for Primary Prevention. in Clinical Laboratory. 2009;55(11-12):411-419.
https://hdl.handle.net/21.15107/rcub_farfar_1198 .

Jovičić, Snežana, Ignjatović, Svetlana, Dajak, Marijana, Kangrga, Ranka, Majkić-Singh, Nada, "Association of Lipid and Inflammatory Markers with C-Reactive Protein in Cardiovascular Risk Assessment for Primary Prevention" in Clinical Laboratory, 55, no. 11-12 (2009):411-419,
https://hdl.handle.net/21.15107/rcub_farfar_1198 .

TY  - JOUR
AU  - Žarković, Miloš
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Ćirić, Jasmina
AU  - Beleslin, Biljana
AU  - Savić, Slavica
AU  - Stojković, Mirjana
AU  - Bulat, Petar
AU  - Trbojević, Bozo
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1026
AB  - Objective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly with cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions.
PB  - Bioscientifica Ltd, Bristol
T2  - European Journal of Endocrinology
T1  - Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans
VL  - 159
IS  - 5
SP  - 649
EP  - 652
DO  - 10.1530/EJE-08-0544
ER  - 

@article{
author = "Žarković, Miloš and Ignjatović, Svetlana and Dajak, Marijana and Ćirić, Jasmina and Beleslin, Biljana and Savić, Slavica and Stojković, Mirjana and Bulat, Petar and Trbojević, Bozo",
year = "2008",
abstract = "Objective: Interleukin 6(IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation. Design and methods: Basal IL6 concentration was measured and a low dose (1 mu g) ACTH test was performed to assess cortisol response. apparently healthy Subjects (11 male. 16 female. mean age 31.1 years. age range 22-47 years) were included in the study. Results: Data are presented as mean +/- S.E.M. Basal IL6 level was 0.84 +/- 0.10 pg/ml, Basal cortisol was 351.9 +/- 18.3. nmol/l. Maximal cortisol during synacthen test was 653.0 +/- 20.6 nmol/l. Maximal cortisol increment was 301.1 +/- 20.0 nmol/l. IL6 concentration was not correlated with basal or maximal cortisol concentration. but correlated significantly with cortisol increment (r=0.63. 95%. confidence interval) 0.42-0.83). Conclusions: In our study. We found that higher basal IL6 concentration is associated with the higher cortisol response to ACTH stimulation. Based on previous research and our data, IL6, even in low concentrations and under physiologic conditions, modulates adrenal cortex responsivity to ACTH. Therefore. it seems that immune modulation of HPA axis is also present under physiologic and not only pathologic conditions.",
publisher = "Bioscientifica Ltd, Bristol",
journal = "European Journal of Endocrinology",
title = "Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans",
volume = "159",
number = "5",
pages = "649-652",
doi = "10.1530/EJE-08-0544"
}

Žarković, M., Ignjatović, S., Dajak, M., Ćirić, J., Beleslin, B., Savić, S., Stojković, M., Bulat, P.,& Trbojević, B.. (2008). Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. in European Journal of Endocrinology
Bioscientifica Ltd, Bristol., 159(5), 649-652.
https://doi.org/10.1530/EJE-08-0544

Žarković M, Ignjatović S, Dajak M, Ćirić J, Beleslin B, Savić S, Stojković M, Bulat P, Trbojević B. Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. in European Journal of Endocrinology. 2008;159(5):649-652.
doi:10.1530/EJE-08-0544 .

Žarković, Miloš, Ignjatović, Svetlana, Dajak, Marijana, Ćirić, Jasmina, Beleslin, Biljana, Savić, Slavica, Stojković, Mirjana, Bulat, Petar, Trbojević, Bozo, "Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans" in European Journal of Endocrinology, 159, no. 5 (2008):649-652,
https://doi.org/10.1530/EJE-08-0544 . .

TY  - JOUR
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
AU  - Jovičić, Snežana
AU  - Majkić-Singh, Nada
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1097
AB  - The glomerullar filtration rate (GFR) is widely accepted as the best overall index of kidney function. GFR can be measured as the clearance of exogenous or endogenous filtration markers or clinically estimated from serum concentrations or creatinine or cystatin C. Recently, it has been recommended that an estimated GFR (eGFR) should be reported in addition to the value of filtration markers. In this study, we determined the values of eGFR, based on creatinine and cystatin C equations, in 125 healthy volunteers aged 20-75 years. Creatinine was measured by a kinetic alkaline picrate method on an ARCHITECT ci8200 analyzer (Abbott Diagnostics, Wiesbaden, Germany). Cystatin C was determined by a latex particle-enhanced immunonephelometric assay (BNII, Dade Behring, Marburg, Germany). The eGFR values were calculated for creatinine using the Modification of Diet in Renal Disease (MDRD) study equation and Rule's quadratic equation and for cystatin C according to the equation published by Hoek et al. The reference intervals for eGFRs with MDRD, Rule's quadratic and Hoek's equations were calculated nonparametrically and were determined to be 63.5-124.6 mL/min/1.73 m(2), 78.3-139.2 mL/min/1.73 m(2) and 72.2-115.6 mL/min/1.73 m(2), respectively. According to the US National Kidney Foundation, chronic kidney disease (CKD) can be defined as a GFR  lt  60 mL/min/1.73 m(2). Our results showed that healthy adults had eGFR values > 63.5 mL/min/1.73 m(2). However, it is important to note that these normal values overlap with values in stages 1 and 2 of CKD, thus an eGFR greater than 60 mL/min/1.73 m(2) does not exclude kidney disease.
PB  - Clin Lab Publ, Heidelberg
T2  - Clinical Laboratory
T1  - The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults
VL  - 54
IS  - 5-6
SP  - 153
EP  - 159
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1097
ER  - 

@article{
author = "Dajak, Marijana and Ignjatović, Svetlana and Jovičić, Snežana and Majkić-Singh, Nada",
year = "2008",
abstract = "The glomerullar filtration rate (GFR) is widely accepted as the best overall index of kidney function. GFR can be measured as the clearance of exogenous or endogenous filtration markers or clinically estimated from serum concentrations or creatinine or cystatin C. Recently, it has been recommended that an estimated GFR (eGFR) should be reported in addition to the value of filtration markers. In this study, we determined the values of eGFR, based on creatinine and cystatin C equations, in 125 healthy volunteers aged 20-75 years. Creatinine was measured by a kinetic alkaline picrate method on an ARCHITECT ci8200 analyzer (Abbott Diagnostics, Wiesbaden, Germany). Cystatin C was determined by a latex particle-enhanced immunonephelometric assay (BNII, Dade Behring, Marburg, Germany). The eGFR values were calculated for creatinine using the Modification of Diet in Renal Disease (MDRD) study equation and Rule's quadratic equation and for cystatin C according to the equation published by Hoek et al. The reference intervals for eGFRs with MDRD, Rule's quadratic and Hoek's equations were calculated nonparametrically and were determined to be 63.5-124.6 mL/min/1.73 m(2), 78.3-139.2 mL/min/1.73 m(2) and 72.2-115.6 mL/min/1.73 m(2), respectively. According to the US National Kidney Foundation, chronic kidney disease (CKD) can be defined as a GFR  lt  60 mL/min/1.73 m(2). Our results showed that healthy adults had eGFR values > 63.5 mL/min/1.73 m(2). However, it is important to note that these normal values overlap with values in stages 1 and 2 of CKD, thus an eGFR greater than 60 mL/min/1.73 m(2) does not exclude kidney disease.",
publisher = "Clin Lab Publ, Heidelberg",
journal = "Clinical Laboratory",
title = "The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults",
volume = "54",
number = "5-6",
pages = "153-159",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1097"
}

Dajak, M., Ignjatović, S., Jovičić, S.,& Majkić-Singh, N.. (2008). The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults. in Clinical Laboratory
Clin Lab Publ, Heidelberg., 54(5-6), 153-159.
https://hdl.handle.net/21.15107/rcub_farfar_1097

Dajak M, Ignjatović S, Jovičić S, Majkić-Singh N. The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults. in Clinical Laboratory. 2008;54(5-6):153-159.
https://hdl.handle.net/21.15107/rcub_farfar_1097 .

Dajak, Marijana, Ignjatović, Svetlana, Jovičić, Snežana, Majkić-Singh, Nada, "The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults" in Clinical Laboratory, 54, no. 5-6 (2008):153-159,
https://hdl.handle.net/21.15107/rcub_farfar_1097 .

TY  - JOUR
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1011
AB  - The glomerular filtration rate (GFR) is widely accepted as the best overall measure of kidney function. American National Kidney Foundation guidelines define chronic kidney disease (CKD) by either a GFR of less than 60 mL/min/1.73 m2 or the presence of kidney damage, regardless of the cause, for 3 or more months, and classify stages of CKD severity according to GFR. GFR can be measured as the urinary or plasma clearance of exogenous filtration markers such as inulin. However, because of difficulty in use, expenses and radiation exposure, these methods have limited use in the routine laboratories. Creatinine clearance may be a useful alternative when exogenous markers are not available, but timed urinary collection is not convenient for patients and is susceptible to error during collection. GFR is often estimated clinically from serum concentrations of endogenous creatinine or cystatin C. Serum cystatin C has not yet been adequately evaluated as an index of GFR, and serum creatinine is affected by the GFR and by factors independent of GFR, including age, sex, race, body size, diet, certain drugs and laboratory analytical methods. According to National Kidney Foundation clinical guidelines, clinical laboratories should report an estimated GFR calculated from prediction equations, in addition to reporting the serum marker value. The currently recommended estimating equation was developed from the Modification of Diet in Renal Disease (MDRD) study. This equation uses age, sex, race (African-American vs. non-African-American), and serum creatinine concentration, and does not require a body weight variable because it normalizes GFR for a standard body surface area of 1.73 m 2. To achieve improved accuracy of calculated GFR with this equation, it is recommended that commercial creatinine methods should be calibrated against certified reference material and should be traceable to IDMS (isotope dilution mass spectrometry) methodology. MDRD equation has been shown to be useful for CKD patients, but its use is still unclear for people with low values for serum creatinine and high values for GFR, including healthy individuals, children and pregnant women. Validation studies are in progress to evaluate the MDRD equation for other ethnic groups and various disease conditions.
AB  - Brzina glomerularne filtracije (GFR) je široko prihvaćena kao najbolja opšta mera funkcije bubrega. Vodiči američke Nacionalne fondacije za bubreg definiš u hroničnu bubrežnu bolest (HBB) bilo sa vrednošću GFR koja je manja od 60 mL/min/1,73 m2 ili sa prisustvom oštećenja bubrega, bez obzira na uzrok, u toku 3 ili više meseci i klasifikuju stadijume težine HBB prema GFR. GFR se može meriti kao urinarni ili plazma klirens egzogenih filtracionih markera kao što je inulin. Međutim, zbog teškoća u primeni, troškova i radijacionog izlaganja, ove metode imaju ograničenu upotrebu u rutinskim laboratorijama. Klirens kreatinina može biti korisna alternativa kada egzogeni markeri nisu dostupni, ali sakupljanje urina u vremenskim intervalima nije pogodno za pacijente i osetljivo je na grešku pri sakupljanju. GFR se često procenjuje klinički iz serumskih koncentracija egzogenog kreatinina ili cistatina C. Cistatin C u serumu još uvek nije adekvatno procenjen kao indeks GFR, a na kreatinin u serumu utiču GFR i faktori nezavisni od GFR, uključujući godine pol, rasu, telesnu veličinu, ishranu, izvesne lekove i laboratorijske analitičke metode. Prema kliničkim vodičima Nacionalne fondacije za bubreg kliničke laboratorije bi trebalo da izdaju "procenjenu " GFR (estimated GFR) izračunatu iz prediktivnih jednačina, kao dodatak izveštavanja vrednosti markera u serumu. Trenutno preporučena jednačina za procenu je razvijena iz MDRD (Modification of Diet in Renal Disease) studije. Ova jednačina koristi godine, pol, rasu (afro-američka prema ne-afro-američkoj) i koncentraciju kreatinina u serumu, a ne zahteva varijablu za telesnu težinu zato što normalizuje GFR za standardnu telesnu površinu od 1,73 m2. Da bi se postigla poboljšana tačnost preračunate GFR sa ovom jednačinom, preporučuje se da komercijalne metode za kreatinin budu kalibrisane prema sertifikovanim referentnim materijalima i sledljive sa IDMS (isotope dilution mass spectrometry) metodologijom. Za MDRD jednačinu je pokazano da je korisna za pacijente sa HBB, ali njena upotreba je još uvek nejasna za ljude sa niskim vrednostima kreatinina u serumu i visokim vrednostima za GFR, uključujući zdrave pojedince, decu i trudnice. Validacione studije su u razvoju kako bi se procenila MDRD jednačina za druge etničke grupe i različita bolesna stanja.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Renal function: Estimation of glomerular filtration rate
T1  - Funkcija bubrega - Procena brzine glomerularne filtracije
VL  - 26
IS  - 1
SP  - 51
EP  - 57
DO  - 10.2478/v10011-007-0010-z
ER  - 

@article{
author = "Dajak, Marijana and Ignjatović, Svetlana and Majkić-Singh, Nada",
year = "2007",
abstract = "The glomerular filtration rate (GFR) is widely accepted as the best overall measure of kidney function. American National Kidney Foundation guidelines define chronic kidney disease (CKD) by either a GFR of less than 60 mL/min/1.73 m2 or the presence of kidney damage, regardless of the cause, for 3 or more months, and classify stages of CKD severity according to GFR. GFR can be measured as the urinary or plasma clearance of exogenous filtration markers such as inulin. However, because of difficulty in use, expenses and radiation exposure, these methods have limited use in the routine laboratories. Creatinine clearance may be a useful alternative when exogenous markers are not available, but timed urinary collection is not convenient for patients and is susceptible to error during collection. GFR is often estimated clinically from serum concentrations of endogenous creatinine or cystatin C. Serum cystatin C has not yet been adequately evaluated as an index of GFR, and serum creatinine is affected by the GFR and by factors independent of GFR, including age, sex, race, body size, diet, certain drugs and laboratory analytical methods. According to National Kidney Foundation clinical guidelines, clinical laboratories should report an estimated GFR calculated from prediction equations, in addition to reporting the serum marker value. The currently recommended estimating equation was developed from the Modification of Diet in Renal Disease (MDRD) study. This equation uses age, sex, race (African-American vs. non-African-American), and serum creatinine concentration, and does not require a body weight variable because it normalizes GFR for a standard body surface area of 1.73 m 2. To achieve improved accuracy of calculated GFR with this equation, it is recommended that commercial creatinine methods should be calibrated against certified reference material and should be traceable to IDMS (isotope dilution mass spectrometry) methodology. MDRD equation has been shown to be useful for CKD patients, but its use is still unclear for people with low values for serum creatinine and high values for GFR, including healthy individuals, children and pregnant women. Validation studies are in progress to evaluate the MDRD equation for other ethnic groups and various disease conditions., Brzina glomerularne filtracije (GFR) je široko prihvaćena kao najbolja opšta mera funkcije bubrega. Vodiči američke Nacionalne fondacije za bubreg definiš u hroničnu bubrežnu bolest (HBB) bilo sa vrednošću GFR koja je manja od 60 mL/min/1,73 m2 ili sa prisustvom oštećenja bubrega, bez obzira na uzrok, u toku 3 ili više meseci i klasifikuju stadijume težine HBB prema GFR. GFR se može meriti kao urinarni ili plazma klirens egzogenih filtracionih markera kao što je inulin. Međutim, zbog teškoća u primeni, troškova i radijacionog izlaganja, ove metode imaju ograničenu upotrebu u rutinskim laboratorijama. Klirens kreatinina može biti korisna alternativa kada egzogeni markeri nisu dostupni, ali sakupljanje urina u vremenskim intervalima nije pogodno za pacijente i osetljivo je na grešku pri sakupljanju. GFR se često procenjuje klinički iz serumskih koncentracija egzogenog kreatinina ili cistatina C. Cistatin C u serumu još uvek nije adekvatno procenjen kao indeks GFR, a na kreatinin u serumu utiču GFR i faktori nezavisni od GFR, uključujući godine pol, rasu, telesnu veličinu, ishranu, izvesne lekove i laboratorijske analitičke metode. Prema kliničkim vodičima Nacionalne fondacije za bubreg kliničke laboratorije bi trebalo da izdaju "procenjenu " GFR (estimated GFR) izračunatu iz prediktivnih jednačina, kao dodatak izveštavanja vrednosti markera u serumu. Trenutno preporučena jednačina za procenu je razvijena iz MDRD (Modification of Diet in Renal Disease) studije. Ova jednačina koristi godine, pol, rasu (afro-američka prema ne-afro-američkoj) i koncentraciju kreatinina u serumu, a ne zahteva varijablu za telesnu težinu zato što normalizuje GFR za standardnu telesnu površinu od 1,73 m2. Da bi se postigla poboljšana tačnost preračunate GFR sa ovom jednačinom, preporučuje se da komercijalne metode za kreatinin budu kalibrisane prema sertifikovanim referentnim materijalima i sledljive sa IDMS (isotope dilution mass spectrometry) metodologijom. Za MDRD jednačinu je pokazano da je korisna za pacijente sa HBB, ali njena upotreba je još uvek nejasna za ljude sa niskim vrednostima kreatinina u serumu i visokim vrednostima za GFR, uključujući zdrave pojedince, decu i trudnice. Validacione studije su u razvoju kako bi se procenila MDRD jednačina za druge etničke grupe i različita bolesna stanja.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Renal function: Estimation of glomerular filtration rate, Funkcija bubrega - Procena brzine glomerularne filtracije",
volume = "26",
number = "1",
pages = "51-57",
doi = "10.2478/v10011-007-0010-z"
}

Dajak, M., Ignjatović, S.,& Majkić-Singh, N.. (2007). Renal function: Estimation of glomerular filtration rate. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 26(1), 51-57.
https://doi.org/10.2478/v10011-007-0010-z

Dajak M, Ignjatović S, Majkić-Singh N. Renal function: Estimation of glomerular filtration rate. in Journal of Medical Biochemistry. 2007;26(1):51-57.
doi:10.2478/v10011-007-0010-z .

Dajak, Marijana, Ignjatović, Svetlana, Majkić-Singh, Nada, "Renal function: Estimation of glomerular filtration rate" in Journal of Medical Biochemistry, 26, no. 1 (2007):51-57,
https://doi.org/10.2478/v10011-007-0010-z . .

TY  - CONF
AU  - Dopsaj, Violeta
AU  - Simić-Ogrizović, Sanja
AU  - Dajak, Marijana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/734
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - The application of laboratory protocols in the investigation on nephrocalculosis
T1  - Primena laboratorijskih protokola u ispitivanju uzroka nefrokalkuloze
VL  - 56
IS  - 5
SP  - 656
EP  - 657
UR  - https://hdl.handle.net/21.15107/rcub_farfar_734
ER  - 

@conference{
author = "Dopsaj, Violeta and Simić-Ogrizović, Sanja and Dajak, Marijana",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "The application of laboratory protocols in the investigation on nephrocalculosis, Primena laboratorijskih protokola u ispitivanju uzroka nefrokalkuloze",
volume = "56",
number = "5",
pages = "656-657",
url = "https://hdl.handle.net/21.15107/rcub_farfar_734"
}

Dopsaj, V., Simić-Ogrizović, S.,& Dajak, M.. (2006). The application of laboratory protocols in the investigation on nephrocalculosis. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(5), 656-657.
https://hdl.handle.net/21.15107/rcub_farfar_734

Dopsaj V, Simić-Ogrizović S, Dajak M. The application of laboratory protocols in the investigation on nephrocalculosis. in Arhiv za farmaciju. 2006;56(5):656-657.
https://hdl.handle.net/21.15107/rcub_farfar_734 .

Dopsaj, Violeta, Simić-Ogrizović, Sanja, Dajak, Marijana, "The application of laboratory protocols in the investigation on nephrocalculosis" in Arhiv za farmaciju, 56, no. 5 (2006):656-657,
https://hdl.handle.net/21.15107/rcub_farfar_734 .

TY  - JOUR
AU  - Jovičić, Snežana
AU  - Ignjatović, Svetlana
AU  - Dajak, Marijana
AU  - Majkić-Singh, Nada
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/850
AB  - Increased C-reactive protein (CRP) concentration within the reference interval ( lt  10.0 mg/L) is a strong predictor of cardiovascular disease (CVD) in apparently healthy adults. Cutoff points for use of CRP in estimating CVD risk are  lt  1, 1-3 and > 3 mg/L for low, average and high relative risk, respectively. For measuring CRP concentrations to assess cardiovascular risk, high-sensitivity CRP ( hsCRP) assays have been developed. The aim of this study was to evaluate the analytical performance and clinical efficacy for cardiovascular risk estimation of the Olympus immunoturbidimetric latex CRP assay ( sensitive application). The comparative method used was the CardioPhase* hsCRP assay, approved by the Food and Drug Administration for use in CVD risk assessment. The imprecision of the Olympus hsCRP assay in the concentration range 0.2-10.0 mg/L was 0.38-8.16% within runs and 3.75-9.63% between runs. For method comparison studies, 194 fresh serum samples were selected to cover the interval 0.15-10.0 mg/L CRP. Comparison of the Dade Behring and Olympus methods was performed using weighted Deming regression analysis ( slope 0.99 mg/L, intercept 0.002 mg/L, S-y,S- x = 0.02 mg/L, r = 0.992) and a Bland-Altman relative difference plot (mean difference - 0.002%, SD = 0.040%). The agreement between the Dade Behring and Olympus methods for relative risk class assignments was 95.4%. Statistical analysis of the agreement between the two methods for each relative risk class showed that the differences between the methods were not statistically significant ( p  lt  0.10). Although previous reports found poor performance of the Olympus CRP tests for use in cardiovascular and peripheral vascular risk estimation, our study proved good analytical performance and clinical efficacy of the Olympus hsCRP assay for this use.
PB  - Walter de Gruyter Gmbh, Berlin
T2  - Clinical Chemistry and Laboratory Medicine
T1  - Analytical performance and clinical efficacy for cardiovascular risk estimation of an Olympus immunoturbidimetric high-sensitivity C-reactive protein assay
VL  - 44
IS  - 2
SP  - 228
EP  - 231
DO  - 10.1515/CCLM.2006.042
ER  - 

@article{
author = "Jovičić, Snežana and Ignjatović, Svetlana and Dajak, Marijana and Majkić-Singh, Nada",
year = "2006",
abstract = "Increased C-reactive protein (CRP) concentration within the reference interval ( lt  10.0 mg/L) is a strong predictor of cardiovascular disease (CVD) in apparently healthy adults. Cutoff points for use of CRP in estimating CVD risk are  lt  1, 1-3 and > 3 mg/L for low, average and high relative risk, respectively. For measuring CRP concentrations to assess cardiovascular risk, high-sensitivity CRP ( hsCRP) assays have been developed. The aim of this study was to evaluate the analytical performance and clinical efficacy for cardiovascular risk estimation of the Olympus immunoturbidimetric latex CRP assay ( sensitive application). The comparative method used was the CardioPhase* hsCRP assay, approved by the Food and Drug Administration for use in CVD risk assessment. The imprecision of the Olympus hsCRP assay in the concentration range 0.2-10.0 mg/L was 0.38-8.16% within runs and 3.75-9.63% between runs. For method comparison studies, 194 fresh serum samples were selected to cover the interval 0.15-10.0 mg/L CRP. Comparison of the Dade Behring and Olympus methods was performed using weighted Deming regression analysis ( slope 0.99 mg/L, intercept 0.002 mg/L, S-y,S- x = 0.02 mg/L, r = 0.992) and a Bland-Altman relative difference plot (mean difference - 0.002%, SD = 0.040%). The agreement between the Dade Behring and Olympus methods for relative risk class assignments was 95.4%. Statistical analysis of the agreement between the two methods for each relative risk class showed that the differences between the methods were not statistically significant ( p  lt  0.10). Although previous reports found poor performance of the Olympus CRP tests for use in cardiovascular and peripheral vascular risk estimation, our study proved good analytical performance and clinical efficacy of the Olympus hsCRP assay for this use.",
publisher = "Walter de Gruyter Gmbh, Berlin",
journal = "Clinical Chemistry and Laboratory Medicine",
title = "Analytical performance and clinical efficacy for cardiovascular risk estimation of an Olympus immunoturbidimetric high-sensitivity C-reactive protein assay",
volume = "44",
number = "2",
pages = "228-231",
doi = "10.1515/CCLM.2006.042"
}

Jovičić, S., Ignjatović, S., Dajak, M.,& Majkić-Singh, N.. (2006). Analytical performance and clinical efficacy for cardiovascular risk estimation of an Olympus immunoturbidimetric high-sensitivity C-reactive protein assay. in Clinical Chemistry and Laboratory Medicine
Walter de Gruyter Gmbh, Berlin., 44(2), 228-231.
https://doi.org/10.1515/CCLM.2006.042

Jovičić S, Ignjatović S, Dajak M, Majkić-Singh N. Analytical performance and clinical efficacy for cardiovascular risk estimation of an Olympus immunoturbidimetric high-sensitivity C-reactive protein assay. in Clinical Chemistry and Laboratory Medicine. 2006;44(2):228-231.
doi:10.1515/CCLM.2006.042 .

Jovičić, Snežana, Ignjatović, Svetlana, Dajak, Marijana, Majkić-Singh, Nada, "Analytical performance and clinical efficacy for cardiovascular risk estimation of an Olympus immunoturbidimetric high-sensitivity C-reactive protein assay" in Clinical Chemistry and Laboratory Medicine, 44, no. 2 (2006):228-231,
https://doi.org/10.1515/CCLM.2006.042 . .

TY  - JOUR
AU  - Dajak, Marijana
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
AU  - Lausević, Željko
AU  - Bukumirović, Vesna
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/687
AB  - We investigated the prognostic value of group II phospholipase A(2) (PLA(2)-II) and C-reactive protein (CRP) in patients of the intensive care unit (ICU) who developed severe inflammatory reaction. In addition, the biochemical markers were correlated with the Simplified Acute Physiological Score II (SAPS II). Our study comprised 40,patients with multiple injuries and 35 patients with sepsis admitted to the ICU, and assessed during a follow-up of as long as 28 days. There were 18 survivors and 17 non-survivors in the sepsis group, and 22 survivors and 18 non-survivors in the group of patients with multiple injuries. In the group of patients with multiple injuries, the intensity of host inflammatory response showed clearly distinct PLA(2)-II and CRP profiles: the overall levels of PLA(2)-II and CRP were significantly higher in non-survivors than in survivors. PLA(2)-II and CRP do not discriminate non-survivors from survivors with sepsis. ROC (receiver operating characteristic curve) analysis and the area under the curve (AUC) showed the best classification of polytrauma patients with SAPS 11 and PLA(2)-II. In the group of patients with sepsis, only SAPS II appeared to be the most helpful predictive measure regarding patient outcome.
PB  - Clin Lab Publications, Heidelberg
T2  - Clinical Laboratory
T1  - Prognostic value of phospholipase A(2) group II, C-reactive protein and simplified acute physiological score II in intensive care patients
VL  - 52
IS  - 7-8
SP  - 387
EP  - 392
UR  - https://hdl.handle.net/21.15107/rcub_farfar_687
ER  - 

@article{
author = "Dajak, Marijana and Ignjatović, Svetlana and Majkić-Singh, Nada and Lausević, Željko and Bukumirović, Vesna",
year = "2006",
abstract = "We investigated the prognostic value of group II phospholipase A(2) (PLA(2)-II) and C-reactive protein (CRP) in patients of the intensive care unit (ICU) who developed severe inflammatory reaction. In addition, the biochemical markers were correlated with the Simplified Acute Physiological Score II (SAPS II). Our study comprised 40,patients with multiple injuries and 35 patients with sepsis admitted to the ICU, and assessed during a follow-up of as long as 28 days. There were 18 survivors and 17 non-survivors in the sepsis group, and 22 survivors and 18 non-survivors in the group of patients with multiple injuries. In the group of patients with multiple injuries, the intensity of host inflammatory response showed clearly distinct PLA(2)-II and CRP profiles: the overall levels of PLA(2)-II and CRP were significantly higher in non-survivors than in survivors. PLA(2)-II and CRP do not discriminate non-survivors from survivors with sepsis. ROC (receiver operating characteristic curve) analysis and the area under the curve (AUC) showed the best classification of polytrauma patients with SAPS 11 and PLA(2)-II. In the group of patients with sepsis, only SAPS II appeared to be the most helpful predictive measure regarding patient outcome.",
publisher = "Clin Lab Publications, Heidelberg",
journal = "Clinical Laboratory",
title = "Prognostic value of phospholipase A(2) group II, C-reactive protein and simplified acute physiological score II in intensive care patients",
volume = "52",
number = "7-8",
pages = "387-392",
url = "https://hdl.handle.net/21.15107/rcub_farfar_687"
}

Dajak, M., Ignjatović, S., Majkić-Singh, N., Lausević, Ž.,& Bukumirović, V.. (2006). Prognostic value of phospholipase A(2) group II, C-reactive protein and simplified acute physiological score II in intensive care patients. in Clinical Laboratory
Clin Lab Publications, Heidelberg., 52(7-8), 387-392.
https://hdl.handle.net/21.15107/rcub_farfar_687

Dajak M, Ignjatović S, Majkić-Singh N, Lausević Ž, Bukumirović V. Prognostic value of phospholipase A(2) group II, C-reactive protein and simplified acute physiological score II in intensive care patients. in Clinical Laboratory. 2006;52(7-8):387-392.
https://hdl.handle.net/21.15107/rcub_farfar_687 .

Dajak, Marijana, Ignjatović, Svetlana, Majkić-Singh, Nada, Lausević, Željko, Bukumirović, Vesna, "Prognostic value of phospholipase A(2) group II, C-reactive protein and simplified acute physiological score II in intensive care patients" in Clinical Laboratory, 52, no. 7-8 (2006):387-392,
https://hdl.handle.net/21.15107/rcub_farfar_687 .