TY  - JOUR
AU  - Bojanin, Dragana
AU  - Milenković, Tatjana
AU  - Vekić, Jelena
AU  - Vuković, Rade
AU  - Zeljković, Aleksandra
AU  - Janać, Jelena
AU  - Ivanišević, Jasmina
AU  - Todorović, Slađana
AU  - Mazibrada, Ilijana
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3153
AB  - Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P  lt  0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P  lt  0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P  lt  0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P  lt  0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P  lt  0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus
VL  - 54
SP  - 11
EP  - 17
DO  - 10.1016/j.clinbiochem.2018.01.026
ER  - 

@article{
author = "Bojanin, Dragana and Milenković, Tatjana and Vekić, Jelena and Vuković, Rade and Zeljković, Aleksandra and Janać, Jelena and Ivanišević, Jasmina and Todorović, Slađana and Mazibrada, Ilijana and Spasojević-Kalimanovska, Vesna",
year = "2018",
abstract = "Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P  lt  0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P  lt  0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P  lt  0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P  lt  0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P  lt  0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus",
volume = "54",
pages = "11-17",
doi = "10.1016/j.clinbiochem.2018.01.026"
}

Bojanin, D., Milenković, T., Vekić, J., Vuković, R., Zeljković, A., Janać, J., Ivanišević, J., Todorović, S., Mazibrada, I.,& Spasojević-Kalimanovska, V.. (2018). Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 54, 11-17.
https://doi.org/10.1016/j.clinbiochem.2018.01.026

Bojanin D, Milenković T, Vekić J, Vuković R, Zeljković A, Janać J, Ivanišević J, Todorović S, Mazibrada I, Spasojević-Kalimanovska V. Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus. in Clinical Biochemistry. 2018;54:11-17.
doi:10.1016/j.clinbiochem.2018.01.026 .

Bojanin, Dragana, Milenković, Tatjana, Vekić, Jelena, Vuković, Rade, Zeljković, Aleksandra, Janać, Jelena, Ivanišević, Jasmina, Todorović, Slađana, Mazibrada, Ilijana, Spasojević-Kalimanovska, Vesna, "Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus" in Clinical Biochemistry, 54 (2018):11-17,
https://doi.org/10.1016/j.clinbiochem.2018.01.026 . .