TY  - JOUR
AU  - Bekhet, Osama H.
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Paripović, Dušan
AU  - Gojković, Tamara
AU  - Janać, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
AU  - Stefanović, Aleksandra
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2845
AB  - N Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and high-density lipoprotein (LDL and HDL) subclasses in a group of obese children, as well as a possible impact of breastfeeding duration on obesity-associated lipoprotein subclasses distributions. Materials and methods: We included 42 obese children, aged 14.2 +/- 2.1 years. LDL and HDL subfractions were separated by gradient gel electrophoresis and biochemical parameters were assessed by routine methods. Results: Compared with obese children with Apgar >= 9, the group with Apgar  lt  9 had significantly higher percentages of small, dense LDL particles (P  lt  0.05), due to reduced LDL I (P  lt  0.01) and increased LDL III subclasses (P  lt  0.05). Birth weight was positively associated with the proportions of LDL I particles (P  lt  0.001), whereas birth height positively correlated with the amount of HDL 2b subclasses (P  lt  0.05). The group of never or less than 3 months breastfed children had significantly smaller LDL size (P  lt  0.01) and lower proportion of HDL 2a particles (P  lt  0.05) than their >= 3 months breastfed peers. Conclusion: The results showed significant associations of neonatal characteristics with LDL and HDL particle distributions in obese children. In addition, our results point toward positive aspects of longer breastfeeding duration on lipoprotein particle distributions in obese children.
PB  - Tubitak Scientific & Technical Research Council Turkey, Ankara
T2  - Upsala Journal of Medical Sciences
T1  - Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity
VL  - 47
IS  - 6
SP  - 1804
EP  - 1812
DO  - 10.3906/sag-1702-164
ER  - 

@article{
author = "Bekhet, Osama H. and Vekić, Jelena and Zeljković, Aleksandra and Paripović, Dušan and Gojković, Tamara and Janać, Jelena and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana and Stefanović, Aleksandra",
year = "2017",
abstract = "N Background/aim: Juvenile obesity is associated with several metabolic abnormalities, one of them being atherogenic dyslipidemia. Suboptimal fetal growth is associated with obesity risk in childhood, but also with increased rate of metabolic diseases in later life. This study investigated associations of neonatal data (Apgar score, birth weight and birth length) with low-density lipoprotein and high-density lipoprotein (LDL and HDL) subclasses in a group of obese children, as well as a possible impact of breastfeeding duration on obesity-associated lipoprotein subclasses distributions. Materials and methods: We included 42 obese children, aged 14.2 +/- 2.1 years. LDL and HDL subfractions were separated by gradient gel electrophoresis and biochemical parameters were assessed by routine methods. Results: Compared with obese children with Apgar >= 9, the group with Apgar  lt  9 had significantly higher percentages of small, dense LDL particles (P  lt  0.05), due to reduced LDL I (P  lt  0.01) and increased LDL III subclasses (P  lt  0.05). Birth weight was positively associated with the proportions of LDL I particles (P  lt  0.001), whereas birth height positively correlated with the amount of HDL 2b subclasses (P  lt  0.05). The group of never or less than 3 months breastfed children had significantly smaller LDL size (P  lt  0.01) and lower proportion of HDL 2a particles (P  lt  0.05) than their >= 3 months breastfed peers. Conclusion: The results showed significant associations of neonatal characteristics with LDL and HDL particle distributions in obese children. In addition, our results point toward positive aspects of longer breastfeeding duration on lipoprotein particle distributions in obese children.",
publisher = "Tubitak Scientific & Technical Research Council Turkey, Ankara",
journal = "Upsala Journal of Medical Sciences",
title = "Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity",
volume = "47",
number = "6",
pages = "1804-1812",
doi = "10.3906/sag-1702-164"
}

Bekhet, O. H., Vekić, J., Zeljković, A., Paripović, D., Gojković, T., Janać, J., Spasojević-Kalimanovska, V., Peco-Antić, A., Miloševski-Lomić, G., Jelić-Ivanović, Z.,& Stefanović, A.. (2017). Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity. in Upsala Journal of Medical Sciences
Tubitak Scientific & Technical Research Council Turkey, Ankara., 47(6), 1804-1812.
https://doi.org/10.3906/sag-1702-164

Bekhet OH, Vekić J, Zeljković A, Paripović D, Gojković T, Janać J, Spasojević-Kalimanovska V, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z, Stefanović A. Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity. in Upsala Journal of Medical Sciences. 2017;47(6):1804-1812.
doi:10.3906/sag-1702-164 .

Bekhet, Osama H., Vekić, Jelena, Zeljković, Aleksandra, Paripović, Dušan, Gojković, Tamara, Janać, Jelena, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, Stefanović, Aleksandra, "Associations of Apgar score and size at birth with lipoprotein subclasses in juvenile obesity" in Upsala Journal of Medical Sciences, 47, no. 6 (2017):1804-1812,
https://doi.org/10.3906/sag-1702-164 . .

TY  - JOUR
AU  - Bekhet, Osama H.
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Paripović, Dušan
AU  - Janać, Jelena
AU  - Joksić, Jelena
AU  - Gojković, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2727
AB  - Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents
VL  - 76
IS  - 6
SP  - 472
EP  - 478
DO  - 10.1080/00365513.2016.1201849
ER  - 

@article{
author = "Bekhet, Osama H. and Zeljković, Aleksandra and Vekić, Jelena and Paripović, Dušan and Janać, Jelena and Joksić, Jelena and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents",
volume = "76",
number = "6",
pages = "472-478",
doi = "10.1080/00365513.2016.1201849"
}

Bekhet, O. H., Zeljković, A., Vekić, J., Paripović, D., Janać, J., Joksić, J., Gojković, T., Spasojević-Kalimanovska, V., Peco-Antić, A., Miloševski-Lomić, G.,& Jelić-Ivanović, Z.. (2016). Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation
Taylor & Francis Ltd, Abingdon., 76(6), 472-478.
https://doi.org/10.1080/00365513.2016.1201849

Bekhet OH, Zeljković A, Vekić J, Paripović D, Janać J, Joksić J, Gojković T, Spasojević-Kalimanovska V, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z. Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation. 2016;76(6):472-478.
doi:10.1080/00365513.2016.1201849 .

Bekhet, Osama H., Zeljković, Aleksandra, Vekić, Jelena, Paripović, Dušan, Janać, Jelena, Joksić, Jelena, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents" in Scandinavian Journal of Clinical and Laboratory Investigation, 76, no. 6 (2016):472-478,
https://doi.org/10.1080/00365513.2016.1201849 . .