TY  - JOUR
AU  - Joksić, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Gojković, Tamara
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Anđelković, Kristina
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2575
AB  - Recent in vitro experiments have indicated that human resistin increases the number of lipoprotein particles secreted by the human hepatocytes and also influences their quality, in terms of generating more proatherogenic lipid particles. The aim of this study is to investigate associations of plasma resistin and peripheral blood mononuclear cells (PBMCs) resistin messenger RNA (mRNA) levels with different prevalence of small, dense low-density lipoprotein particles (sdLDL) in patients with indications for coronary angiography. This study included 65 patients requiring coronary angiography. There were 41 patients without significant stenosis and 24 patients with significant stenosis in at least one major coronary artery. Circulating resistin was measured by enzyme-linked immunosorbent assay; PBMC resistin mRNA was determined by real-time polymerase chain reaction. The LDL and high density lipoprotein subclasses were determined by gradient gel electrophoresis. Plasma resistin (P = 0.031) and PBMCs resistin mRNA (P = 0.004) were significantly higher in patients with proportion of sdLDL particles >= 50%, compared to the group with relative proportion of sdLDL particles  lt  50%. Plasma resistin correlated positively with creatinine (r = 0.456, P  lt  0.001) and resistin mRNA (r = 0.298, P = 0.014) but negatively with body mass index (r = -0.254, P = 0.034) and total cholesterol (r = -0.286, P = 0.021). Multiple linear regression analysis revealed LDL particle diameter as the only independent predictor of resistin mRNA (R-2 = 0.258; adjR(2) = 0.190). A significant association between resistin, both PBMCs mRNA and plasma protein, and the relative proportion of sdLDL particles in the circulation of coronary artery disease patients has been established, which implies that increased gene expression of resistin in PBMCs and higher resistin concentration in plasma are related to pro-atherogenic LDL particle phenotype.
PB  - Wiley, Hoboken
T2  - Clinical and Experimental Pharmacology and Physiology
T1  - Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients
VL  - 43
IS  - 1
SP  - 22
EP  - 28
DO  - 10.1111/1440-1681.12503
ER  - 

@article{
author = "Joksić, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Gojković, Tamara and Zeljković, Aleksandra and Vekić, Jelena and Anđelković, Kristina and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Recent in vitro experiments have indicated that human resistin increases the number of lipoprotein particles secreted by the human hepatocytes and also influences their quality, in terms of generating more proatherogenic lipid particles. The aim of this study is to investigate associations of plasma resistin and peripheral blood mononuclear cells (PBMCs) resistin messenger RNA (mRNA) levels with different prevalence of small, dense low-density lipoprotein particles (sdLDL) in patients with indications for coronary angiography. This study included 65 patients requiring coronary angiography. There were 41 patients without significant stenosis and 24 patients with significant stenosis in at least one major coronary artery. Circulating resistin was measured by enzyme-linked immunosorbent assay; PBMC resistin mRNA was determined by real-time polymerase chain reaction. The LDL and high density lipoprotein subclasses were determined by gradient gel electrophoresis. Plasma resistin (P = 0.031) and PBMCs resistin mRNA (P = 0.004) were significantly higher in patients with proportion of sdLDL particles >= 50%, compared to the group with relative proportion of sdLDL particles  lt  50%. Plasma resistin correlated positively with creatinine (r = 0.456, P  lt  0.001) and resistin mRNA (r = 0.298, P = 0.014) but negatively with body mass index (r = -0.254, P = 0.034) and total cholesterol (r = -0.286, P = 0.021). Multiple linear regression analysis revealed LDL particle diameter as the only independent predictor of resistin mRNA (R-2 = 0.258; adjR(2) = 0.190). A significant association between resistin, both PBMCs mRNA and plasma protein, and the relative proportion of sdLDL particles in the circulation of coronary artery disease patients has been established, which implies that increased gene expression of resistin in PBMCs and higher resistin concentration in plasma are related to pro-atherogenic LDL particle phenotype.",
publisher = "Wiley, Hoboken",
journal = "Clinical and Experimental Pharmacology and Physiology",
title = "Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients",
volume = "43",
number = "1",
pages = "22-28",
doi = "10.1111/1440-1681.12503"
}

Joksić, J., Sopić, M., Spasojević-Kalimanovska, V., Gojković, T., Zeljković, A., Vekić, J., Anđelković, K., Kalimanovska-Oštrić, D.,& Jelić-Ivanović, Z.. (2016). Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients. in Clinical and Experimental Pharmacology and Physiology
Wiley, Hoboken., 43(1), 22-28.
https://doi.org/10.1111/1440-1681.12503

Joksić J, Sopić M, Spasojević-Kalimanovska V, Gojković T, Zeljković A, Vekić J, Anđelković K, Kalimanovska-Oštrić D, Jelić-Ivanović Z. Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients. in Clinical and Experimental Pharmacology and Physiology. 2016;43(1):22-28.
doi:10.1111/1440-1681.12503 .

Joksić, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Gojković, Tamara, Zeljković, Aleksandra, Vekić, Jelena, Anđelković, Kristina, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, "Higher circulating resistin protein and PBMCs resistin mRNA levels are associated with increased prevalence of small dense LDL particles in coronary artery disease patients" in Clinical and Experimental Pharmacology and Physiology, 43, no. 1 (2016):22-28,
https://doi.org/10.1111/1440-1681.12503 . .

TY  - CONF
AU  - Sopić, Miron
AU  - Joksić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Andelković, Kristina
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2646
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease
VL  - 252
SP  - e246
EP  - e247
DO  - 10.1016/j.atherosclerosis.2016.07.046
ER  - 

@conference{
author = "Sopić, Miron and Joksić, Jelena and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Andelković, Kristina and Jelić-Ivanović, Zorana",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease",
volume = "252",
pages = "e246-e247",
doi = "10.1016/j.atherosclerosis.2016.07.046"
}

Sopić, M., Joksić, J., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Andelković, K.,& Jelić-Ivanović, Z.. (2016). Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 252, e246-e247.
https://doi.org/10.1016/j.atherosclerosis.2016.07.046

Sopić M, Joksić J, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Andelković K, Jelić-Ivanović Z. Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease. in Atherosclerosis. 2016;252:e246-e247.
doi:10.1016/j.atherosclerosis.2016.07.046 .

Sopić, Miron, Joksić, Jelena, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Andelković, Kristina, Jelić-Ivanović, Zorana, "Association of peripheral blood mononuclear cells adenylate cyclase-associated protein 1 mRNA with coronary artery disease" in Atherosclerosis, 252 (2016):e246-e247,
https://doi.org/10.1016/j.atherosclerosis.2016.07.046 . .

TY  - JOUR
AU  - Sopić, Miron
AU  - Joksić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Simić-Ogrizović, Sanja
AU  - Kravljaca, Milica
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2750
AB  - Background: Since the rise in plasma adiponectin levels in chronic kidney disease (CKD) patients has not yet been elucidated, we sought to investigate if patients on hemodialysis (HD) have altered expression of adiponectin receptors in peripheral blood mononuclear cells (PBMCs) compared to healthy subjects. Methods: This study included 31 patients with chronic kidney disease on HD and 33 healthy subjects (CG). Circulating adiponectin levels were measured by ELISA while AdipoR1 and AdipoR2 mRNA levels in PBMCs were determined by real-time PCR. Results: Plasma adiponectin levels were significantly higher in patients compared to control group (P=0.036). After adjustment for age, BMI and creatinine, this difference became even more significant (P=0.004). In both groups adiponectin correlated with creatinine (CG: r=-0.472, P=0.006; HD: r=-0.375, P=0.038), triglycerides (CG: r=0.490, P=0.004; HD: r=-0.488, P=0.005), insulin (CG: r=-0.386, P=0.038; HD: r=-0.506, P=0.012) and high density lipoprotein cholesterol (HDL-C) (CG: r=-0.672, P lt 0.001; HD: r=-0.584, P=0.001). Significantly lower expression of PBMCs AdipoR1 mRNA was found in patients compared to CG (P=0.034), while AdipoR2 mRNA levels were similarly expressed in PBMCs in both groups. Conclusions: Complex pathological processes in CKD cause downregulation of AdipoR1 which could ultimately influence AdipoR1 protein levels leading to a state of adiponectin resistance.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients
VL  - 35
IS  - 4
SP  - 436
EP  - 442
DO  - 10.1515/jomb-2016-0007
ER  - 

@article{
author = "Sopić, Miron and Joksić, Jelena and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Simić-Ogrizović, Sanja and Kravljaca, Milica and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Background: Since the rise in plasma adiponectin levels in chronic kidney disease (CKD) patients has not yet been elucidated, we sought to investigate if patients on hemodialysis (HD) have altered expression of adiponectin receptors in peripheral blood mononuclear cells (PBMCs) compared to healthy subjects. Methods: This study included 31 patients with chronic kidney disease on HD and 33 healthy subjects (CG). Circulating adiponectin levels were measured by ELISA while AdipoR1 and AdipoR2 mRNA levels in PBMCs were determined by real-time PCR. Results: Plasma adiponectin levels were significantly higher in patients compared to control group (P=0.036). After adjustment for age, BMI and creatinine, this difference became even more significant (P=0.004). In both groups adiponectin correlated with creatinine (CG: r=-0.472, P=0.006; HD: r=-0.375, P=0.038), triglycerides (CG: r=0.490, P=0.004; HD: r=-0.488, P=0.005), insulin (CG: r=-0.386, P=0.038; HD: r=-0.506, P=0.012) and high density lipoprotein cholesterol (HDL-C) (CG: r=-0.672, P lt 0.001; HD: r=-0.584, P=0.001). Significantly lower expression of PBMCs AdipoR1 mRNA was found in patients compared to CG (P=0.034), while AdipoR2 mRNA levels were similarly expressed in PBMCs in both groups. Conclusions: Complex pathological processes in CKD cause downregulation of AdipoR1 which could ultimately influence AdipoR1 protein levels leading to a state of adiponectin resistance.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients",
volume = "35",
number = "4",
pages = "436-442",
doi = "10.1515/jomb-2016-0007"
}

Sopić, M., Joksić, J., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Simić-Ogrizović, S., Kravljaca, M.,& Jelić-Ivanović, Z.. (2016). Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(4), 436-442.
https://doi.org/10.1515/jomb-2016-0007

Sopić M, Joksić J, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Simić-Ogrizović S, Kravljaca M, Jelić-Ivanović Z. Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients. in Journal of Medical Biochemistry. 2016;35(4):436-442.
doi:10.1515/jomb-2016-0007 .

Sopić, Miron, Joksić, Jelena, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Simić-Ogrizović, Sanja, Kravljaca, Milica, Jelić-Ivanović, Zorana, "Downregulation of AdipoR1 is Associated with Increased Circulating Adiponectin Levels in Serbian Chronic Kidney Disease Patients" in Journal of Medical Biochemistry, 35, no. 4 (2016):436-442,
https://doi.org/10.1515/jomb-2016-0007 . .

TY  - JOUR
AU  - Bekhet, Osama H.
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Paripović, Dušan
AU  - Janać, Jelena
AU  - Joksić, Jelena
AU  - Gojković, Tamara
AU  - Spasojević-Kalimanovska, Vesna
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2727
AB  - Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents
VL  - 76
IS  - 6
SP  - 472
EP  - 478
DO  - 10.1080/00365513.2016.1201849
ER  - 

@article{
author = "Bekhet, Osama H. and Zeljković, Aleksandra and Vekić, Jelena and Paripović, Dušan and Janać, Jelena and Joksić, Jelena and Gojković, Tamara and Spasojević-Kalimanovska, Vesna and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana",
year = "2016",
abstract = "Background: Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.Methods: A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.Results: Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p= 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles ( =-0.423; p= 0.025) in the group with hypertension.Conclusions: The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents",
volume = "76",
number = "6",
pages = "472-478",
doi = "10.1080/00365513.2016.1201849"
}

Bekhet, O. H., Zeljković, A., Vekić, J., Paripović, D., Janać, J., Joksić, J., Gojković, T., Spasojević-Kalimanovska, V., Peco-Antić, A., Miloševski-Lomić, G.,& Jelić-Ivanović, Z.. (2016). Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation
Taylor & Francis Ltd, Abingdon., 76(6), 472-478.
https://doi.org/10.1080/00365513.2016.1201849

Bekhet OH, Zeljković A, Vekić J, Paripović D, Janać J, Joksić J, Gojković T, Spasojević-Kalimanovska V, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z. Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation. 2016;76(6):472-478.
doi:10.1080/00365513.2016.1201849 .

Bekhet, Osama H., Zeljković, Aleksandra, Vekić, Jelena, Paripović, Dušan, Janać, Jelena, Joksić, Jelena, Gojković, Tamara, Spasojević-Kalimanovska, Vesna, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, "Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents" in Scandinavian Journal of Clinical and Laboratory Investigation, 76, no. 6 (2016):472-478,
https://doi.org/10.1080/00365513.2016.1201849 . .

TY  - JOUR
AU  - Joksić, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Anđelković, Kristina
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2465
AB  - Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P = 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P  lt  0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.
PB  - Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb
T2  - Biochemia Medica
T1  - Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease
VL  - 25
IS  - 2
SP  - 242
EP  - 251
DO  - 10.11613/BM.2015.025
ER  - 

@article{
author = "Joksić, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Anđelković, Kristina and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Introduction: Previous studies have implicated a strong link between circulating plasma resistin and coronary artery disease (CAD). The aim of this study was to evaluate the differences in peripheral blood mononuclear cells (PBMC) resistin mRNA and its plasma protein concentrations between the patients with CAD of different clinical severity. Material and methods: This study included 33 healthy subjects as the control group (CG) and 77 patients requiring coronary angiography. Of the latter 30 was CAD negative whereas 47 were CAD positive [18 with stable angina pectoris (SAP) and 29 with acute coronary syndrome (ACS)]. Circulating resistin was measured by ELISA; PBMC resistin mRNA was determined by real-time PCR. Results: Resistin protein was significantly higher in the ACS group compared to the CG (P = 0.001) and the CAD negative group (P = 0.018). Resistin mRNA expression did not vary across the study groups, despite the positive correlation seen with plasma resistin (rho = 0.305, P = 0.008). In patients, plasma resistin and PBMC resistin mRNA negatively correlated with HDL-C (rho = -0.404, P  lt  0.001 and rho = -0.257, P = 0.032, respectively). Furthermore, the highest plasma resistin tertile showed the lowest HDL-C (P = 0.006). Plasma resistin was positively associated with serum creatinine (rho = 0.353, P = 0.002). Conclusion: Significant increase of plasma resistin in patients with ACS compared to CG and CAD negative patients was observed. Despite no change in PBMC resistin mRNA in different disease conditions a positive association between resistin mRNA and resistin plasma protein was evident. Both plasma resistin and PBMC resistin mRNA were negatively associated with plasma HDL-C, and plasma resistin positively with serum creatinine.",
publisher = "Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb",
journal = "Biochemia Medica",
title = "Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease",
volume = "25",
number = "2",
pages = "242-251",
doi = "10.11613/BM.2015.025"
}

Joksić, J., Sopić, M., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Anđelković, K.,& Jelić-Ivanović, Z.. (2015). Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease. in Biochemia Medica
Croatian Soc Medical Biochemistry & Laboratory Medicine, Zagreb., 25(2), 242-251.
https://doi.org/10.11613/BM.2015.025

Joksić J, Sopić M, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Anđelković K, Jelić-Ivanović Z. Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease. in Biochemia Medica. 2015;25(2):242-251.
doi:10.11613/BM.2015.025 .

Joksić, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Anđelković, Kristina, Jelić-Ivanović, Zorana, "Circulating resistin protein and mRNA concentrations and clinical severity of coronary artery disease" in Biochemia Medica, 25, no. 2 (2015):242-251,
https://doi.org/10.11613/BM.2015.025 . .

TY  - CONF
AU  - Sopić, Miron
AU  - Joksić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Gojković, Tamara
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2443
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis
T1  - Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease
VL  - 241
IS  - 1
SP  - e151
EP  - e151
DO  - 10.1016/j.atherosclerosis.2015.04.770
ER  - 

@conference{
author = "Sopić, Miron and Joksić, Jelena and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Gojković, Tamara and Zeljković, Aleksandra and Vekić, Jelena and Jelić-Ivanović, Zorana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease",
volume = "241",
number = "1",
pages = "e151-e151",
doi = "10.1016/j.atherosclerosis.2015.04.770"
}

Sopić, M., Joksić, J., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Gojković, T., Zeljković, A., Vekić, J.,& Jelić-Ivanović, Z.. (2015). Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 241(1), e151-e151.
https://doi.org/10.1016/j.atherosclerosis.2015.04.770

Sopić M, Joksić J, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Gojković T, Zeljković A, Vekić J, Jelić-Ivanović Z. Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease. in Atherosclerosis. 2015;241(1):e151-e151.
doi:10.1016/j.atherosclerosis.2015.04.770 .

Sopić, Miron, Joksić, Jelena, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Gojković, Tamara, Zeljković, Aleksandra, Vekić, Jelena, Jelić-Ivanović, Zorana, "Association of resistin mrna and plasma levels with small dense ldl particles in coronary artery disease" in Atherosclerosis, 241, no. 1 (2015):e151-e151,
https://doi.org/10.1016/j.atherosclerosis.2015.04.770 . .

TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Jelić-Ivanović, Zorana
AU  - Stefanović, Aleksandra
AU  - Gojković, Tamara
AU  - Joksić, Jelena
AU  - Sopić, Miron
AU  - Gulan, Brankica
AU  - Janać, Jelena
AU  - Milošević, Sanja
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2407
AB  - Objective: The connection of oxidative stress with dyslipidemia creates a newly-emerging atherosclerosis risk factor involved in acute ischemic stroke development. This study analyzed the influence of oxidative stress on structural changes of high-density lipoprotein (HDL) particles connected with modification in protective paraoxonase 1 (PON1) activity. Methods: This study used 185 patients with acute ischemic stroke and 185 apparently healthy controls. Oxidative stress status, PON1 status, lipids and high-sensitivity C-reactive protein (hsCRP) were determined. In isolated HDL lipoprotein fraction we determined selected markers of oxidative stress (malondialdehyde, MDA) and the content of total sulfhydryl (SH) groups. The capability of oxidative and PON1 status parameters to discriminate patients according to survival status was evaluated. Results: Stroke patients had lower HDL-cholesterol than controls and a remarkable fall in PON1 activity (control group-227 U/L, survivors-42 U/L, lethal outcome group-61 U/L, p  lt  0.001), along with more prominent inflammation. Pronounced oxidative stress and impaired antioxidative protection was present among patients. HDL fraction analysis revealed a significant decrease of SH groups content (control group vs. patients, p  lt  0.05) and increased in MDA content in patients (lethal outcome vs. control group, p  lt  0.05). According to logistic regression analysis, the best predictor of disease outcome was oxidative stress marker - prooxidative-antioxidative balance (PAB). Conclusions: Pronounced oxidative stress in this group of acute ischemic stroke patients probably led to HDL structural changes, which could further cause an alteration or decrease of PON1 activity. Evidence of increased prooxidant level associated with decreased protective, antioxidative factors suggests their mutual involvement in this complex pathology.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients
VL  - 241
IS  - 1
SP  - 192
EP  - 198
DO  - 10.1016/j.atherosclerosis.2015.05.016
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Stefanović, Aleksandra and Gojković, Tamara and Joksić, Jelena and Sopić, Miron and Gulan, Brankica and Janać, Jelena and Milošević, Sanja",
year = "2015",
abstract = "Objective: The connection of oxidative stress with dyslipidemia creates a newly-emerging atherosclerosis risk factor involved in acute ischemic stroke development. This study analyzed the influence of oxidative stress on structural changes of high-density lipoprotein (HDL) particles connected with modification in protective paraoxonase 1 (PON1) activity. Methods: This study used 185 patients with acute ischemic stroke and 185 apparently healthy controls. Oxidative stress status, PON1 status, lipids and high-sensitivity C-reactive protein (hsCRP) were determined. In isolated HDL lipoprotein fraction we determined selected markers of oxidative stress (malondialdehyde, MDA) and the content of total sulfhydryl (SH) groups. The capability of oxidative and PON1 status parameters to discriminate patients according to survival status was evaluated. Results: Stroke patients had lower HDL-cholesterol than controls and a remarkable fall in PON1 activity (control group-227 U/L, survivors-42 U/L, lethal outcome group-61 U/L, p  lt  0.001), along with more prominent inflammation. Pronounced oxidative stress and impaired antioxidative protection was present among patients. HDL fraction analysis revealed a significant decrease of SH groups content (control group vs. patients, p  lt  0.05) and increased in MDA content in patients (lethal outcome vs. control group, p  lt  0.05). According to logistic regression analysis, the best predictor of disease outcome was oxidative stress marker - prooxidative-antioxidative balance (PAB). Conclusions: Pronounced oxidative stress in this group of acute ischemic stroke patients probably led to HDL structural changes, which could further cause an alteration or decrease of PON1 activity. Evidence of increased prooxidant level associated with decreased protective, antioxidative factors suggests their mutual involvement in this complex pathology.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients",
volume = "241",
number = "1",
pages = "192-198",
doi = "10.1016/j.atherosclerosis.2015.05.016"
}

Kotur-Stevuljević, J., Bogavac-Stanojević, N., Jelić-Ivanović, Z., Stefanović, A., Gojković, T., Joksić, J., Sopić, M., Gulan, B., Janać, J.,& Milošević, S.. (2015). Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 241(1), 192-198.
https://doi.org/10.1016/j.atherosclerosis.2015.05.016

Kotur-Stevuljević J, Bogavac-Stanojević N, Jelić-Ivanović Z, Stefanović A, Gojković T, Joksić J, Sopić M, Gulan B, Janać J, Milošević S. Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients. in Atherosclerosis. 2015;241(1):192-198.
doi:10.1016/j.atherosclerosis.2015.05.016 .

Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Stefanović, Aleksandra, Gojković, Tamara, Joksić, Jelena, Sopić, Miron, Gulan, Brankica, Janać, Jelena, Milošević, Sanja, "Oxidative stress and paraoxonase 1 status in acute ischemic stroke patients" in Atherosclerosis, 241, no. 1 (2015):192-198,
https://doi.org/10.1016/j.atherosclerosis.2015.05.016 . .

TY  - JOUR
AU  - Pavlović, Branko
AU  - Milosavljević, Jovana
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Joksić, Jelena
AU  - Sopić, Miron
AU  - Spasojević-Kalimanovska, Vesna
AU  - Paripović, Dušan
AU  - Peco-Antić, Amira
AU  - Miloševski-Lomić, Gordana
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2514
AB  - Introduction: Childhood obesity is related to cardiovascular diseases and diabetes mellitus type 2 in later life. Resistin, an adipokine primarily secreted by monocytes and tissue macrophages in humans, is considered to be associated with these conditions. The Aim: To examine the correlations between resistin concentration and anthropometric parameters, lipid status, inflammatory markers and parameters of insulin resistance in obese children and adolescents. Material and Methods: The study included 66 patients (40 boys, 26 girls), which underwent anthropometric measuring and laboratory testing (glucose level, total cholesterol, high-density lipoprotein cholesterol (HDL-cholesterol), low-density lipoprotein cholesterol (LDL-cholesterol), triglycerides, uric acid, high-sensitivity C-reactive protein (hsCRP) and glycosylated hemoglobin (HbA1c). Insulin resistance was estimated with HOMA-IR (homeostasis model assessment of insulin resistance). Results: We determined that 63.3% of our patients had dyslipidemia, while hsCRP and uric acid levels suggested an ongoing inflammation. We established that there was a correlation between resistin concentration and waist to hip ratio (WHR) (r=0.294, p lt 0.05), as well as between resistin concentration and HOMA-IR (r=0.293, p lt 0.05). Also, uric acid levels correlated with obesity parameters. While comparing parameters by gender we found a significant difference in height (p lt 0.01), WHR (p lt 0.001), uric acid levels (p lt 0.01) and HOMA-IR (p lt 0.01). Conclusion: Our results show a link between obesity, inflammation and dyslipidemia in children and adolescents. In the future, resistin could become a significant clinical marker for evaluation of cardiometabolic risk.
AB  - Uvod: Gojaznost u dečjem uzrastu se povezuje sa razvojem kardiovaskularnih bolesti i tipa 2 dijabetes melitusa u kasnijem dobu. Smatra se da je rezistin, adipokin kojeg u humanom organizumu luče monociti i tkivne makrofage, povezan sa ovim poremećajima. Cilj: Ispitati povezanost koncentracije rezistina kod gojazne dece i adolescenata sa antropometrijskim parametrima gojaznosti, lipidnim statusom, inflamatornim markerima i parametrima insulinske rezistencije. Materijal i metode: U istraživanju je učestvovalo 66 ispitanika (40 dečaka, 26 devojčica) kojima su izvršena antropometrijska merenja i laboratorijska ispitivanja (koncentracije glukoze, ukupnog holesterola, holesterola u česticama lipoproteina visoke gustine (eng. high-density lipoprotein, HDL) i niske gustine (eng. low-density lipoprotein, LDL), triglicerida, mokraćne kiseline, visokoosetljivog C-reaktivnog proteina (high-sensitivity C-reactive protein; hsCRP) i glikoziliranog hemoglobina (HbA1c)). Insulinska rezistencija je procenjena na osnovu modela za izračunavanje indeksa insulinske rezistencije (eng. homeostasis model assessment of insulin resistance; HOMA-IR). Rezultati: Kod 63,3% ispitanika utvrdili smo prisutnu dislipidemiju, a dobijene vrednosti hsCRP i mokraćne kiseline ukazuju na prisustvo inflamacije. Utvrdili smo korelaciju između koncentracije rezistina i odnosa obima struka i kukova (r=0,294, p lt 0,05) i između koncentracije rezistina i HOMA-IR (r=0,293, p lt 0,05). Ustanovili smo povezanost koncentracije mokraćne kiseline i parametara gojaznosti. Upoređivanjem parametara između polova, značajna razlika postoji u telesnoj visini (p lt 0,01), odnosu obima struka i kukova (p lt 0,001), mokraćnoj kiselini (p lt 0,01) i HOMA-IR (p lt 0,01). Zaključak: Naši rezultati ukazuju na povezanost gojaznosti, inflamacije i dislipidemije kod dece i adolescenata. Rezistin bi u budućnosti mogao biti značajan za procenu kardiometaboličkog rizika u ovoj populaciji.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Resistin, inflammation and dyslipidemia in obese children and adolescents
T1  - Rezistin, inflamacija i dislipidemija kod gojazne dece i adolescenata
VL  - 65
IS  - 2
SP  - 115
EP  - 128
DO  - 10.5937/arhfarm1502115P
ER  - 

@article{
author = "Pavlović, Branko and Milosavljević, Jovana and Zeljković, Aleksandra and Vekić, Jelena and Joksić, Jelena and Sopić, Miron and Spasojević-Kalimanovska, Vesna and Paripović, Dušan and Peco-Antić, Amira and Miloševski-Lomić, Gordana and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Introduction: Childhood obesity is related to cardiovascular diseases and diabetes mellitus type 2 in later life. Resistin, an adipokine primarily secreted by monocytes and tissue macrophages in humans, is considered to be associated with these conditions. The Aim: To examine the correlations between resistin concentration and anthropometric parameters, lipid status, inflammatory markers and parameters of insulin resistance in obese children and adolescents. Material and Methods: The study included 66 patients (40 boys, 26 girls), which underwent anthropometric measuring and laboratory testing (glucose level, total cholesterol, high-density lipoprotein cholesterol (HDL-cholesterol), low-density lipoprotein cholesterol (LDL-cholesterol), triglycerides, uric acid, high-sensitivity C-reactive protein (hsCRP) and glycosylated hemoglobin (HbA1c). Insulin resistance was estimated with HOMA-IR (homeostasis model assessment of insulin resistance). Results: We determined that 63.3% of our patients had dyslipidemia, while hsCRP and uric acid levels suggested an ongoing inflammation. We established that there was a correlation between resistin concentration and waist to hip ratio (WHR) (r=0.294, p lt 0.05), as well as between resistin concentration and HOMA-IR (r=0.293, p lt 0.05). Also, uric acid levels correlated with obesity parameters. While comparing parameters by gender we found a significant difference in height (p lt 0.01), WHR (p lt 0.001), uric acid levels (p lt 0.01) and HOMA-IR (p lt 0.01). Conclusion: Our results show a link between obesity, inflammation and dyslipidemia in children and adolescents. In the future, resistin could become a significant clinical marker for evaluation of cardiometabolic risk., Uvod: Gojaznost u dečjem uzrastu se povezuje sa razvojem kardiovaskularnih bolesti i tipa 2 dijabetes melitusa u kasnijem dobu. Smatra se da je rezistin, adipokin kojeg u humanom organizumu luče monociti i tkivne makrofage, povezan sa ovim poremećajima. Cilj: Ispitati povezanost koncentracije rezistina kod gojazne dece i adolescenata sa antropometrijskim parametrima gojaznosti, lipidnim statusom, inflamatornim markerima i parametrima insulinske rezistencije. Materijal i metode: U istraživanju je učestvovalo 66 ispitanika (40 dečaka, 26 devojčica) kojima su izvršena antropometrijska merenja i laboratorijska ispitivanja (koncentracije glukoze, ukupnog holesterola, holesterola u česticama lipoproteina visoke gustine (eng. high-density lipoprotein, HDL) i niske gustine (eng. low-density lipoprotein, LDL), triglicerida, mokraćne kiseline, visokoosetljivog C-reaktivnog proteina (high-sensitivity C-reactive protein; hsCRP) i glikoziliranog hemoglobina (HbA1c)). Insulinska rezistencija je procenjena na osnovu modela za izračunavanje indeksa insulinske rezistencije (eng. homeostasis model assessment of insulin resistance; HOMA-IR). Rezultati: Kod 63,3% ispitanika utvrdili smo prisutnu dislipidemiju, a dobijene vrednosti hsCRP i mokraćne kiseline ukazuju na prisustvo inflamacije. Utvrdili smo korelaciju između koncentracije rezistina i odnosa obima struka i kukova (r=0,294, p lt 0,05) i između koncentracije rezistina i HOMA-IR (r=0,293, p lt 0,05). Ustanovili smo povezanost koncentracije mokraćne kiseline i parametara gojaznosti. Upoređivanjem parametara između polova, značajna razlika postoji u telesnoj visini (p lt 0,01), odnosu obima struka i kukova (p lt 0,001), mokraćnoj kiselini (p lt 0,01) i HOMA-IR (p lt 0,01). Zaključak: Naši rezultati ukazuju na povezanost gojaznosti, inflamacije i dislipidemije kod dece i adolescenata. Rezistin bi u budućnosti mogao biti značajan za procenu kardiometaboličkog rizika u ovoj populaciji.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Resistin, inflammation and dyslipidemia in obese children and adolescents, Rezistin, inflamacija i dislipidemija kod gojazne dece i adolescenata",
volume = "65",
number = "2",
pages = "115-128",
doi = "10.5937/arhfarm1502115P"
}

Pavlović, B., Milosavljević, J., Zeljković, A., Vekić, J., Joksić, J., Sopić, M., Spasojević-Kalimanovska, V., Paripović, D., Peco-Antić, A., Miloševski-Lomić, G.,& Jelić-Ivanović, Z.. (2015). Resistin, inflammation and dyslipidemia in obese children and adolescents. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 65(2), 115-128.
https://doi.org/10.5937/arhfarm1502115P

Pavlović B, Milosavljević J, Zeljković A, Vekić J, Joksić J, Sopić M, Spasojević-Kalimanovska V, Paripović D, Peco-Antić A, Miloševski-Lomić G, Jelić-Ivanović Z. Resistin, inflammation and dyslipidemia in obese children and adolescents. in Arhiv za farmaciju. 2015;65(2):115-128.
doi:10.5937/arhfarm1502115P .

Pavlović, Branko, Milosavljević, Jovana, Zeljković, Aleksandra, Vekić, Jelena, Joksić, Jelena, Sopić, Miron, Spasojević-Kalimanovska, Vesna, Paripović, Dušan, Peco-Antić, Amira, Miloševski-Lomić, Gordana, Jelić-Ivanović, Zorana, "Resistin, inflammation and dyslipidemia in obese children and adolescents" in Arhiv za farmaciju, 65, no. 2 (2015):115-128,
https://doi.org/10.5937/arhfarm1502115P . .

TY  - JOUR
AU  - Sopić, Miron
AU  - Joksić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Andelković, Kristina
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2417
AB  - The aim of the present study was to investigate if circulating adiponectin levels and the expression of AdipoR1 and AdipoR2 in peripheral blood mononuclear cells (PBMC) are altered in coronary artery disease (CAD) patients, with and without significant stenosis, compared to healthy patients. The present study included 69 patients with presenting symptoms of CAD (26 patients with significant stenosis and 43 patients without significant stenosis). The control group (CG) consisted of 33 healthy patients. Circulating adiponectin levels were measured by enzyme-linked immunosorbent assay, whereas AdipoR1 and AdipoR2 mRNA levels in PBMC were determined by real-time polymerase chain reaction. Adiponectin levels were significantly higher in patients with and without significant stenosis compared to the CG (P lt 0.001 vs P=0.006, respectively). Both patient groups had lower AdipoR1 levels compared to the CG (P lt 0.001 vs P lt 0.001, respectively). There were no significant differences in these parameters between the two patient groups. Adiponectin negatively correlated with body mass index, triglycerides, insulin and homeostasis model assessment of insulin resistance index (HOMA IR), and positively with high-denisty lipoprotein cholesterol in the CG. Glucose, insulin, and the HOMA IR index negatively correlated with adiponectin in patients. A positive correlation between adiponectin receptors was found in patients and the CG. Decreased AdipoR1 mRNA levels and increased circulating adiponectin in advanced stages of CAD, as well as in patients without significant stenosis, compared to the CG, implies that CAD could be related to adiponectin resistance'. Despite increased adiponectin, its protective effects could be diminished even in early stages of atherosclerosis.
PB  - Wiley, Hoboken
T2  - Clinical and Experimental Pharmacology and Physiology
T1  - Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?
VL  - 42
IS  - 4
SP  - 331
EP  - 336
DO  - 10.1111/1440-1681.12361
ER  - 

@article{
author = "Sopić, Miron and Joksić, Jelena and Spasojević-Kalimanovska, Vesna and Kalimanovska-Oštrić, Dimitra and Andelković, Kristina and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "The aim of the present study was to investigate if circulating adiponectin levels and the expression of AdipoR1 and AdipoR2 in peripheral blood mononuclear cells (PBMC) are altered in coronary artery disease (CAD) patients, with and without significant stenosis, compared to healthy patients. The present study included 69 patients with presenting symptoms of CAD (26 patients with significant stenosis and 43 patients without significant stenosis). The control group (CG) consisted of 33 healthy patients. Circulating adiponectin levels were measured by enzyme-linked immunosorbent assay, whereas AdipoR1 and AdipoR2 mRNA levels in PBMC were determined by real-time polymerase chain reaction. Adiponectin levels were significantly higher in patients with and without significant stenosis compared to the CG (P lt 0.001 vs P=0.006, respectively). Both patient groups had lower AdipoR1 levels compared to the CG (P lt 0.001 vs P lt 0.001, respectively). There were no significant differences in these parameters between the two patient groups. Adiponectin negatively correlated with body mass index, triglycerides, insulin and homeostasis model assessment of insulin resistance index (HOMA IR), and positively with high-denisty lipoprotein cholesterol in the CG. Glucose, insulin, and the HOMA IR index negatively correlated with adiponectin in patients. A positive correlation between adiponectin receptors was found in patients and the CG. Decreased AdipoR1 mRNA levels and increased circulating adiponectin in advanced stages of CAD, as well as in patients without significant stenosis, compared to the CG, implies that CAD could be related to adiponectin resistance'. Despite increased adiponectin, its protective effects could be diminished even in early stages of atherosclerosis.",
publisher = "Wiley, Hoboken",
journal = "Clinical and Experimental Pharmacology and Physiology",
title = "Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?",
volume = "42",
number = "4",
pages = "331-336",
doi = "10.1111/1440-1681.12361"
}

Sopić, M., Joksić, J., Spasojević-Kalimanovska, V., Kalimanovska-Oštrić, D., Andelković, K.,& Jelić-Ivanović, Z.. (2015). Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?. in Clinical and Experimental Pharmacology and Physiology
Wiley, Hoboken., 42(4), 331-336.
https://doi.org/10.1111/1440-1681.12361

Sopić M, Joksić J, Spasojević-Kalimanovska V, Kalimanovska-Oštrić D, Andelković K, Jelić-Ivanović Z. Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?. in Clinical and Experimental Pharmacology and Physiology. 2015;42(4):331-336.
doi:10.1111/1440-1681.12361 .

Sopić, Miron, Joksić, Jelena, Spasojević-Kalimanovska, Vesna, Kalimanovska-Oštrić, Dimitra, Andelković, Kristina, Jelić-Ivanović, Zorana, "Are decreased AdipoR1 mRNA levels associated with adiponectin resistance in coronary artery disease patients?" in Clinical and Experimental Pharmacology and Physiology, 42, no. 4 (2015):331-336,
https://doi.org/10.1111/1440-1681.12361 . .

TY  - JOUR
AU  - Petrović, Sandra
AU  - Leskovac, Andreja
AU  - Kotur-Stevuljević, Jelena
AU  - Joksić, Jelena
AU  - Guc-Scekić, Marija
AU  - Vujić, Dragana
AU  - Joksić, Gordana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1563
AB  - Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic bone marrow failure (idBMF) and FA cells, and to analyze oxidant state of cells in FA heterozygous carriers as well. The results of the present study confirm an in vivo prooxidant state of FA cells and clearly indicate that FA patients can be distinguished from idBMF patients based on the oxidant state of cells. Female carriers of FA mutation also exhibited hallmarks of an in vivo prooxidant state behaving in a similar manner as FA patients. On the other hand, the oxidant state of cells in FA male carriers and idBMF families failed to show any significant difference vs. controls. We demonstrate that the altered oxidant state influences susceptibility of cells to apoptosis in both FA patients and female carriers. The results highlight the need for further research of the possible role of mitochondrial inheritance in the pathogenesis of FA.
PB  - Walter de Gruyter & Co, Berlin
T2  - Biological Chemistry
T1  - Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes
VL  - 392
IS  - 7
SP  - 625
EP  - 632
DO  - 10.1515/BC.2011.064
ER  - 

@article{
author = "Petrović, Sandra and Leskovac, Andreja and Kotur-Stevuljević, Jelena and Joksić, Jelena and Guc-Scekić, Marija and Vujić, Dragana and Joksić, Gordana",
year = "2011",
abstract = "Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic bone marrow failure (idBMF) and FA cells, and to analyze oxidant state of cells in FA heterozygous carriers as well. The results of the present study confirm an in vivo prooxidant state of FA cells and clearly indicate that FA patients can be distinguished from idBMF patients based on the oxidant state of cells. Female carriers of FA mutation also exhibited hallmarks of an in vivo prooxidant state behaving in a similar manner as FA patients. On the other hand, the oxidant state of cells in FA male carriers and idBMF families failed to show any significant difference vs. controls. We demonstrate that the altered oxidant state influences susceptibility of cells to apoptosis in both FA patients and female carriers. The results highlight the need for further research of the possible role of mitochondrial inheritance in the pathogenesis of FA.",
publisher = "Walter de Gruyter & Co, Berlin",
journal = "Biological Chemistry",
title = "Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes",
volume = "392",
number = "7",
pages = "625-632",
doi = "10.1515/BC.2011.064"
}

Petrović, S., Leskovac, A., Kotur-Stevuljević, J., Joksić, J., Guc-Scekić, M., Vujić, D.,& Joksić, G.. (2011). Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes. in Biological Chemistry
Walter de Gruyter & Co, Berlin., 392(7), 625-632.
https://doi.org/10.1515/BC.2011.064

Petrović S, Leskovac A, Kotur-Stevuljević J, Joksić J, Guc-Scekić M, Vujić D, Joksić G. Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes. in Biological Chemistry. 2011;392(7):625-632.
doi:10.1515/BC.2011.064 .

Petrović, Sandra, Leskovac, Andreja, Kotur-Stevuljević, Jelena, Joksić, Jelena, Guc-Scekić, Marija, Vujić, Dragana, Joksić, Gordana, "Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes" in Biological Chemistry, 392, no. 7 (2011):625-632,
https://doi.org/10.1515/BC.2011.064 . .