TY  - JOUR
AU  - Mitrović, Mirjana
AU  - Šumarac, Zorica
AU  - Antić, Darko
AU  - Bogdanović, Andrija
AU  - Elezović, Ivo
AU  - Vukosavljević, Dragana
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
AU  - Suvajdzić, Nada
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1754
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Blood Cells Molecules and Diseases
T1  - Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy
VL  - 49
IS  - 1
SP  - 58
EP  - 59
DO  - 10.1016/j.bcmd.2012.03.003
ER  - 

@article{
author = "Mitrović, Mirjana and Šumarac, Zorica and Antić, Darko and Bogdanović, Andrija and Elezović, Ivo and Vukosavljević, Dragana and Ignjatović, Svetlana and Majkić-Singh, Nada and Suvajdzić, Nada",
year = "2012",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Blood Cells Molecules and Diseases",
title = "Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy",
volume = "49",
number = "1",
pages = "58-59",
doi = "10.1016/j.bcmd.2012.03.003"
}

Mitrović, M., Šumarac, Z., Antić, D., Bogdanović, A., Elezović, I., Vukosavljević, D., Ignjatović, S., Majkić-Singh, N.,& Suvajdzić, N.. (2012). Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy. in Blood Cells Molecules and Diseases
Academic Press Inc Elsevier Science, San Diego., 49(1), 58-59.
https://doi.org/10.1016/j.bcmd.2012.03.003

Mitrović M, Šumarac Z, Antić D, Bogdanović A, Elezović I, Vukosavljević D, Ignjatović S, Majkić-Singh N, Suvajdzić N. Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy. in Blood Cells Molecules and Diseases. 2012;49(1):58-59.
doi:10.1016/j.bcmd.2012.03.003 .

Mitrović, Mirjana, Šumarac, Zorica, Antić, Darko, Bogdanović, Andrija, Elezović, Ivo, Vukosavljević, Dragana, Ignjatović, Svetlana, Majkić-Singh, Nada, Suvajdzić, Nada, "Markers of coagulation activation and enhanced fibrinolysis in Gaucher type 1 patient: Effects of enzyme replacement therapy" in Blood Cells Molecules and Diseases, 49, no. 1 (2012):58-59,
https://doi.org/10.1016/j.bcmd.2012.03.003 . .

TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Bogavac-Stanojević, Nataša
AU  - Vasić, Dragan
AU  - Vukosavljević, Dragana
AU  - Martinović, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1180
AB  - Many studies have investigated the clinical accuracy of the D-dimer test in combination with pretest probability score for deep venous thrombosis (DVT) exclusion. However, few have evaluated its potential when combined with additional markers such as fibrin monomer. The aim of this study was to test the incremental usefulness of fibrin monomer for DVT screening in a bi-marker approach. This was achieved by adding the fibrin monomer to logistic models that included different D-dimer tests. Plasma concentrations of D-dimer and fibrin monomer were measured in 96 outpatients suspected of having DVT and in 76 patients selected from the total patient group according to pretest probability score (termed the DVT-unlikely group). We constructed receiver operating characteristic curves for three different D-dimer assays. Predictive probabilities from different logistic regression models and pair-wise comparisons of the areas under the receiver operating characteristic curve (AUCs) were calculated without and with fibrin monomer included in the models. For all three D-dimer assays, the AUCs were higher in the DVT-unlikely group compared with AUCs in the total patient group [but the differences were without statistical significance (P>0.05)]. The calculated fibrin monomer AUCs (0.724 in the total patient group and 0.683 in the DVT-unlikely group) were lower than the D-dimer tests' AUCs. The AUCs obtained from logistic regression models that included the three D-dimer tests in the total patient group and the DVT-unlikely group were significantly increased when fibrin monomer was included in the model to such an extent that the AUCs for one of them indicated outstanding discriminative abilities. Simultaneous D-dimer and fibrin monomer determination provides a more valuable approximation for DVT exclusion compared with just D-dimer analysis. Bearing in mind that the fibrin monomer assay is now both more practical and more suited for routine clinical use, fibrin monomer determination could be a more commonly used parameter together with D-dimer and pretest probability score for DVT diagnosis in the future. Blood Coagul Fibrinolysis 20:546-551
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Blood Coagulation & Fibrinolysis
T1  - Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?
VL  - 20
IS  - 7
SP  - 546
EP  - 551
DO  - 10.1097/MBC.0b013e32832e0605
ER  - 

@article{
author = "Dopsaj, Violeta and Bogavac-Stanojević, Nataša and Vasić, Dragan and Vukosavljević, Dragana and Martinović, Jelena and Kotur-Stevuljević, Jelena and Spasić, Slavica",
year = "2009",
abstract = "Many studies have investigated the clinical accuracy of the D-dimer test in combination with pretest probability score for deep venous thrombosis (DVT) exclusion. However, few have evaluated its potential when combined with additional markers such as fibrin monomer. The aim of this study was to test the incremental usefulness of fibrin monomer for DVT screening in a bi-marker approach. This was achieved by adding the fibrin monomer to logistic models that included different D-dimer tests. Plasma concentrations of D-dimer and fibrin monomer were measured in 96 outpatients suspected of having DVT and in 76 patients selected from the total patient group according to pretest probability score (termed the DVT-unlikely group). We constructed receiver operating characteristic curves for three different D-dimer assays. Predictive probabilities from different logistic regression models and pair-wise comparisons of the areas under the receiver operating characteristic curve (AUCs) were calculated without and with fibrin monomer included in the models. For all three D-dimer assays, the AUCs were higher in the DVT-unlikely group compared with AUCs in the total patient group [but the differences were without statistical significance (P>0.05)]. The calculated fibrin monomer AUCs (0.724 in the total patient group and 0.683 in the DVT-unlikely group) were lower than the D-dimer tests' AUCs. The AUCs obtained from logistic regression models that included the three D-dimer tests in the total patient group and the DVT-unlikely group were significantly increased when fibrin monomer was included in the model to such an extent that the AUCs for one of them indicated outstanding discriminative abilities. Simultaneous D-dimer and fibrin monomer determination provides a more valuable approximation for DVT exclusion compared with just D-dimer analysis. Bearing in mind that the fibrin monomer assay is now both more practical and more suited for routine clinical use, fibrin monomer determination could be a more commonly used parameter together with D-dimer and pretest probability score for DVT diagnosis in the future. Blood Coagul Fibrinolysis 20:546-551",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Blood Coagulation & Fibrinolysis",
title = "Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?",
volume = "20",
number = "7",
pages = "546-551",
doi = "10.1097/MBC.0b013e32832e0605"
}

Dopsaj, V., Bogavac-Stanojević, N., Vasić, D., Vukosavljević, D., Martinović, J., Kotur-Stevuljević, J.,& Spasić, S.. (2009). Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?. in Blood Coagulation & Fibrinolysis
Lippincott Williams & Wilkins, Philadelphia., 20(7), 546-551.
https://doi.org/10.1097/MBC.0b013e32832e0605

Dopsaj V, Bogavac-Stanojević N, Vasić D, Vukosavljević D, Martinović J, Kotur-Stevuljević J, Spasić S. Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?. in Blood Coagulation & Fibrinolysis. 2009;20(7):546-551.
doi:10.1097/MBC.0b013e32832e0605 .

Dopsaj, Violeta, Bogavac-Stanojević, Nataša, Vasić, Dragan, Vukosavljević, Dragana, Martinović, Jelena, Kotur-Stevuljević, Jelena, Spasić, Slavica, "Excluding deep venous thrombosis in symptomatic outpatients: is fibrin monomer aid to D-dimer analysis?" in Blood Coagulation & Fibrinolysis, 20, no. 7 (2009):546-551,
https://doi.org/10.1097/MBC.0b013e32832e0605 . .

TY  - JOUR
AU  - Vukosavljević, Dragana
AU  - Bumbaširević, Ljiljana
AU  - Stefanović, Aleksandra
AU  - Stojanov, Marina
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/655
AB  - The differential diagnosis between inflammatory and noninflammatory diseases of CNS includes CSF quantitative measurements of immunoglobulin and albumin concentrations and their comparison to the serum. For that purpose we estimated the concentrations of albumin and immunoglobulin G both in CSF and serum of patients with inflammatory and noninflammatory diseases of CNS. Parallely, these parameters were determined in the control group composed of patients having the values of investigated parameters within reference ranges. The obtained data were statistically evaluated by nonparametric Mann-Whitney test. The values of calculated CSF/albumin ratio have shown significant differences between the both patient groups and the control one (p  lt  0.001). It proves that in each examined group the blood brain barrier is damaged. For the assessment of intrathecal IgG synthesis we have calculated both IgG/albumin index and Schuller index. The comparison of the values obtained for patients with noninflammatory diseases to the control one, revealed no statistically significant differences (p > 0.05). On the contrary, significant difference have been observed between the group with inflammatory diseases and the control (p  lt  0.05), proving the existence of IgG intrathecal synthesis. Values of both indexes were much higher in patients with inflammatory than noninflamatory diseases, meaning that they can be used in differential diagnosis.
AB  - Diferencijalna dijagnoza inflamatornih i neinflamatornih oboljenja CNS-a, obuhvata kvantitativno određivanje koncentracija imunoglobulina i albumina, kao i njihovo poređenje sa serumom. Koncentracije albumina i imunoglobulina G određene su u cerebrospinalnoj tečnosti (CST) u serumu pacijenata sa inflamatornim i neinflamatornim oboljenjima CNS-a. Ovi parametri određeni su i u kontrolnoj grupi, sačinjenoj od pacijenata kod kojih su ispitivani parametri bili u granicama referentnih vrednosti. Dobijeni rezultati statistički su obrađeni neparametarskim Mann-Whitney testom. Izračunate vrednosti CSF/albumin pokazale su statistički značajne razlike između obe grupe pacijenata i kontrolne grupe (p lt  0,001). Ovo dokazuje da je kod obe grupe pacijenata krvno moždana barijera oštećena. Za procenu intratekalne sinteze IgG izračunati su Ig/albumin indeks i Schuller-ov index. Poređenjem vrednosti za pacijente sa nezapaljenskim oboljenjima i kontrolne grupe nisu nađene značajne razlike (p > 0,05). Suprotno, statistički značajne razlike uočene su između grupe sa inflamatornim oboljenjima i kontrolne grupe (p  lt  0,05), što ukazuje na postojanje intratekalne sinteze IgG-a. Vrednosti izračunatih indeksa za zapaljenske procese bile su značajno više u odnosu na nezapaljenska oboljenja (p  lt  0,05), što se može iskoristiti za diferencijalnu dijagnozu ovih oboljenja.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Diagnostic value of CSF proteins assay in differential diagnosis of CNS disease
T1  - Dijagnostički značaj određivanja proteina u cerebrospinalnoj tečnosti kod diferencijalne dijagnostike oboljenja CNS-a
VL  - 24
IS  - 2
SP  - 107
EP  - 110
DO  - 10.2298/JMH0502107V
ER  - 

@article{
author = "Vukosavljević, Dragana and Bumbaširević, Ljiljana and Stefanović, Aleksandra and Stojanov, Marina",
year = "2005",
abstract = "The differential diagnosis between inflammatory and noninflammatory diseases of CNS includes CSF quantitative measurements of immunoglobulin and albumin concentrations and their comparison to the serum. For that purpose we estimated the concentrations of albumin and immunoglobulin G both in CSF and serum of patients with inflammatory and noninflammatory diseases of CNS. Parallely, these parameters were determined in the control group composed of patients having the values of investigated parameters within reference ranges. The obtained data were statistically evaluated by nonparametric Mann-Whitney test. The values of calculated CSF/albumin ratio have shown significant differences between the both patient groups and the control one (p  lt  0.001). It proves that in each examined group the blood brain barrier is damaged. For the assessment of intrathecal IgG synthesis we have calculated both IgG/albumin index and Schuller index. The comparison of the values obtained for patients with noninflammatory diseases to the control one, revealed no statistically significant differences (p > 0.05). On the contrary, significant difference have been observed between the group with inflammatory diseases and the control (p  lt  0.05), proving the existence of IgG intrathecal synthesis. Values of both indexes were much higher in patients with inflammatory than noninflamatory diseases, meaning that they can be used in differential diagnosis., Diferencijalna dijagnoza inflamatornih i neinflamatornih oboljenja CNS-a, obuhvata kvantitativno određivanje koncentracija imunoglobulina i albumina, kao i njihovo poređenje sa serumom. Koncentracije albumina i imunoglobulina G određene su u cerebrospinalnoj tečnosti (CST) u serumu pacijenata sa inflamatornim i neinflamatornim oboljenjima CNS-a. Ovi parametri određeni su i u kontrolnoj grupi, sačinjenoj od pacijenata kod kojih su ispitivani parametri bili u granicama referentnih vrednosti. Dobijeni rezultati statistički su obrađeni neparametarskim Mann-Whitney testom. Izračunate vrednosti CSF/albumin pokazale su statistički značajne razlike između obe grupe pacijenata i kontrolne grupe (p lt  0,001). Ovo dokazuje da je kod obe grupe pacijenata krvno moždana barijera oštećena. Za procenu intratekalne sinteze IgG izračunati su Ig/albumin indeks i Schuller-ov index. Poređenjem vrednosti za pacijente sa nezapaljenskim oboljenjima i kontrolne grupe nisu nađene značajne razlike (p > 0,05). Suprotno, statistički značajne razlike uočene su između grupe sa inflamatornim oboljenjima i kontrolne grupe (p  lt  0,05), što ukazuje na postojanje intratekalne sinteze IgG-a. Vrednosti izračunatih indeksa za zapaljenske procese bile su značajno više u odnosu na nezapaljenska oboljenja (p  lt  0,05), što se može iskoristiti za diferencijalnu dijagnozu ovih oboljenja.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Diagnostic value of CSF proteins assay in differential diagnosis of CNS disease, Dijagnostički značaj određivanja proteina u cerebrospinalnoj tečnosti kod diferencijalne dijagnostike oboljenja CNS-a",
volume = "24",
number = "2",
pages = "107-110",
doi = "10.2298/JMH0502107V"
}

Vukosavljević, D., Bumbaširević, L., Stefanović, A.,& Stojanov, M.. (2005). Diagnostic value of CSF proteins assay in differential diagnosis of CNS disease. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 24(2), 107-110.
https://doi.org/10.2298/JMH0502107V

Vukosavljević D, Bumbaširević L, Stefanović A, Stojanov M. Diagnostic value of CSF proteins assay in differential diagnosis of CNS disease. in Jugoslovenska medicinska biohemija. 2005;24(2):107-110.
doi:10.2298/JMH0502107V .

Vukosavljević, Dragana, Bumbaširević, Ljiljana, Stefanović, Aleksandra, Stojanov, Marina, "Diagnostic value of CSF proteins assay in differential diagnosis of CNS disease" in Jugoslovenska medicinska biohemija, 24, no. 2 (2005):107-110,
https://doi.org/10.2298/JMH0502107V . .