TY  - CONF
AU  - Todorović, Z.
AU  - Todorović, Vanja
AU  - Šobajić, Slađana
AU  - Stojičević, Saša S.
AU  - Marjanović, J.
AU  - Nikolić, N.
AU  - Lazić, Miodrag
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1479
PB  - Georg Thieme Verlag Kg, Stuttgart
C3  - Planta Medica
T1  - Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes
VL  - 77
IS  - 12
SP  - 1286
EP  - 1286
DO  - 10.1055/s-0031-1282298
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1479
ER  - 

@conference{
author = "Todorović, Z. and Todorović, Vanja and Šobajić, Slađana and Stojičević, Saša S. and Marjanović, J. and Nikolić, N. and Lazić, Miodrag",
year = "2011",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Planta Medica",
title = "Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes",
volume = "77",
number = "12",
pages = "1286-1286",
doi = "10.1055/s-0031-1282298",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1479"
}

Todorović, Z., Todorović, V., Šobajić, S., Stojičević, S. S., Marjanović, J., Nikolić, N.,& Lazić, M.. (2011). Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes. in Planta Medica
Georg Thieme Verlag Kg, Stuttgart., 77(12), 1286-1286.
https://doi.org/10.1055/s-0031-1282298
https://hdl.handle.net/21.15107/rcub_farfar_1479

Todorović Z, Todorović V, Šobajić S, Stojičević SS, Marjanović J, Nikolić N, Lazić M. Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes. in Planta Medica. 2011;77(12):1286-1286.
doi:10.1055/s-0031-1282298
https://hdl.handle.net/21.15107/rcub_farfar_1479 .

Todorović, Z., Todorović, Vanja, Šobajić, Slađana, Stojičević, Saša S., Marjanović, J., Nikolić, N., Lazić, Miodrag, "Antioxidant capacity of phenolic phytochemicals from peel of apples, pears, plums, red and white grapes" in Planta Medica, 77, no. 12 (2011):1286-1286,
https://doi.org/10.1055/s-0031-1282298 .,
https://hdl.handle.net/21.15107/rcub_farfar_1479 .

TY  - JOUR
AU  - Nikolić, N
AU  - Veselinović, D
AU  - Vladimirov, S
AU  - Karljiković-Rajić, Katarina
AU  - Lingeman, H
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/534
AB  - Tc-99m(V)-d,l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime) synthesis, for reduction of intermediary reactant diiminebisoxime (DI) (4,8-diaza-3,6,6,9-tetramethylundecane-3,8-diene-2,10-dione bisoxime) concerned two reductants (NaBH4 and KBH4), two solvents (ethanol and 2-propanol), and three mole ratios of reactant/reductants (1:1, 1:1.5, and 1:2). The simultaneous analysis of diastereo-enantiomeric HM-PAO content, as well as the content of starting DI, in different reduction mixtures were pet-formed using chiral ligand-exchange chromatography (CLEC). The separation of the samples of investigated reduction mixtures, obtained in the second step of HM-PAO synthesis, has been accomplished by using an achiral sorbent (RP- 18) and a chiral mobile phase (CMP) containing copper(II) complex with N,N-ditnethyl-L-phenylalanine (L-DM-PhA) as initial complex for CLEC. With 12 different reduction conditions, the obtained ratios of diastereoisomers d,l-HM-PAO: mesa-HM-PAO varied from 69.2:30.8 to 15.9:84.1, in comparison to the reduction in routine synthesis of HM-PAO which gives an equal mixture of diastereoisomers. The ternary mixed complexes formation recorded spectrophotometrically on addition of HM-PAO or DI to the mobile phase with binary complex Cu(L-DM-PhA)(2), due to the evidence of bathochromic shift of 46 nm for lambda(max) with significant difference in absorptivity contributes to separation mechanism.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity
VL  - 34
IS  - 2
SP  - 285
EP  - 293
DO  - 10.1016/S0731-7085(03)00551-X
ER  - 

@article{
author = "Nikolić, N and Veselinović, D and Vladimirov, S and Karljiković-Rajić, Katarina and Lingeman, H",
year = "2004",
abstract = "Tc-99m(V)-d,l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime) synthesis, for reduction of intermediary reactant diiminebisoxime (DI) (4,8-diaza-3,6,6,9-tetramethylundecane-3,8-diene-2,10-dione bisoxime) concerned two reductants (NaBH4 and KBH4), two solvents (ethanol and 2-propanol), and three mole ratios of reactant/reductants (1:1, 1:1.5, and 1:2). The simultaneous analysis of diastereo-enantiomeric HM-PAO content, as well as the content of starting DI, in different reduction mixtures were pet-formed using chiral ligand-exchange chromatography (CLEC). The separation of the samples of investigated reduction mixtures, obtained in the second step of HM-PAO synthesis, has been accomplished by using an achiral sorbent (RP- 18) and a chiral mobile phase (CMP) containing copper(II) complex with N,N-ditnethyl-L-phenylalanine (L-DM-PhA) as initial complex for CLEC. With 12 different reduction conditions, the obtained ratios of diastereoisomers d,l-HM-PAO: mesa-HM-PAO varied from 69.2:30.8 to 15.9:84.1, in comparison to the reduction in routine synthesis of HM-PAO which gives an equal mixture of diastereoisomers. The ternary mixed complexes formation recorded spectrophotometrically on addition of HM-PAO or DI to the mobile phase with binary complex Cu(L-DM-PhA)(2), due to the evidence of bathochromic shift of 46 nm for lambda(max) with significant difference in absorptivity contributes to separation mechanism.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity",
volume = "34",
number = "2",
pages = "285-293",
doi = "10.1016/S0731-7085(03)00551-X"
}

Nikolić, N., Veselinović, D., Vladimirov, S., Karljiković-Rajić, K.,& Lingeman, H.. (2004). Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier Science BV, Amsterdam., 34(2), 285-293.
https://doi.org/10.1016/S0731-7085(03)00551-X

Nikolić N, Veselinović D, Vladimirov S, Karljiković-Rajić K, Lingeman H. Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity. in Journal of Pharmaceutical and Biomedical Analysis. 2004;34(2):285-293.
doi:10.1016/S0731-7085(03)00551-X .

Nikolić, N, Veselinović, D, Vladimirov, S, Karljiković-Rajić, Katarina, Lingeman, H, "Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity" in Journal of Pharmaceutical and Biomedical Analysis, 34, no. 2 (2004):285-293,
https://doi.org/10.1016/S0731-7085(03)00551-X . .

TY  - JOUR
AU  - Nikolić, N
AU  - Veselinović, D
AU  - Vucina, J
AU  - Lingeman, H
AU  - Karljiković-Rajić, Katarina
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/436
AB  - The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylalanine (l-DM-PhA), based on the ligand-exchange principle, has been applied. The separation is based on the presence of the immobilized binary complex Cu(l-DM-PhA)(2) and formation of mixed ternary complex. The optimal mole ratio of Cu(II):l-DM-PhA is 1:4, the pH should be between 4.1 and 4.2 and up to 0.8 mM of triethylamine is added for column presaturation with the initial complex. The elution order has been defined using isolated l-HM-PAO via l-HM-PAO L(+)tartrate and tneso-HM-PAO obtained by repeated recrystallization from the isomeric mixture of HM-PAO. Complete resolution between all isomers (R-S from 2.14 to 3.91) and partial resolution for meso(EE)/l-HM-PAO (R-S = 0.83) has been obtained. This means that the proposed chiral ligand-exchange chromatography (CLEC) can be used for determination of the isomeric purity of HM-PAO. This as an alternative method for resolution measurements with chiral columns.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime
VL  - 32
IS  - 6
SP  - 1159
EP  - 1166
DO  - 10.1016/S0731-7085(03)00230-9
ER  - 

@article{
author = "Nikolić, N and Veselinović, D and Vucina, J and Lingeman, H and Karljiković-Rajić, Katarina",
year = "2003",
abstract = "The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylalanine (l-DM-PhA), based on the ligand-exchange principle, has been applied. The separation is based on the presence of the immobilized binary complex Cu(l-DM-PhA)(2) and formation of mixed ternary complex. The optimal mole ratio of Cu(II):l-DM-PhA is 1:4, the pH should be between 4.1 and 4.2 and up to 0.8 mM of triethylamine is added for column presaturation with the initial complex. The elution order has been defined using isolated l-HM-PAO via l-HM-PAO L(+)tartrate and tneso-HM-PAO obtained by repeated recrystallization from the isomeric mixture of HM-PAO. Complete resolution between all isomers (R-S from 2.14 to 3.91) and partial resolution for meso(EE)/l-HM-PAO (R-S = 0.83) has been obtained. This means that the proposed chiral ligand-exchange chromatography (CLEC) can be used for determination of the isomeric purity of HM-PAO. This as an alternative method for resolution measurements with chiral columns.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime",
volume = "32",
number = "6",
pages = "1159-1166",
doi = "10.1016/S0731-7085(03)00230-9"
}

Nikolić, N., Veselinović, D., Vucina, J., Lingeman, H.,& Karljiković-Rajić, K.. (2003). Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime. in Journal of Pharmaceutical and Biomedical Analysis
Pergamon-Elsevier Science Ltd, Oxford., 32(6), 1159-1166.
https://doi.org/10.1016/S0731-7085(03)00230-9

Nikolić N, Veselinović D, Vucina J, Lingeman H, Karljiković-Rajić K. Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime. in Journal of Pharmaceutical and Biomedical Analysis. 2003;32(6):1159-1166.
doi:10.1016/S0731-7085(03)00230-9 .

Nikolić, N, Veselinović, D, Vucina, J, Lingeman, H, Karljiković-Rajić, Katarina, "Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime" in Journal of Pharmaceutical and Biomedical Analysis, 32, no. 6 (2003):1159-1166,
https://doi.org/10.1016/S0731-7085(03)00230-9 . .

TY  - JOUR
AU  - Todorović, Aleksandar
AU  - Karljiković-Rajić, Katarina
AU  - Agbaba, Danica
AU  - Vukicević-Nikolić, N
AU  - Riley, T.N
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/397
AB  - The role of the pharmacist and of pharmacy education within a modern patient-based approach is important as is having an adequate curricula for a professional pharmaceutical degree. Although there are various approaches in the field of education, this study has focused on three different educational models as exemplified by the Faculty of Pharmacy, Belgrade University, FR Yugoslavia; the Faculty of Pharmacy, Salamanca University, Spain; the School of Pharmacy, Auburn University, USA. It is reported that there are some similarities and specific deviations among the models described in this study. Special effort has been made to correlate the different types of pharmaceutical education with the involvement of chemistry and chemical courses within each of them. There is a difference between the various models and the impact of chemistry in them.
PB  - International Pharmaceutical Federation
T2  - Pharmacy Education
T1  - Different approaches in pharmaceutical education: Comparison of three educational models
VL  - 2
IS  - 4
SP  - 209
EP  - 212
DO  - 10.1080/1560221021000061823
ER  - 

@article{
author = "Todorović, Aleksandar and Karljiković-Rajić, Katarina and Agbaba, Danica and Vukicević-Nikolić, N and Riley, T.N",
year = "2002",
abstract = "The role of the pharmacist and of pharmacy education within a modern patient-based approach is important as is having an adequate curricula for a professional pharmaceutical degree. Although there are various approaches in the field of education, this study has focused on three different educational models as exemplified by the Faculty of Pharmacy, Belgrade University, FR Yugoslavia; the Faculty of Pharmacy, Salamanca University, Spain; the School of Pharmacy, Auburn University, USA. It is reported that there are some similarities and specific deviations among the models described in this study. Special effort has been made to correlate the different types of pharmaceutical education with the involvement of chemistry and chemical courses within each of them. There is a difference between the various models and the impact of chemistry in them.",
publisher = "International Pharmaceutical Federation",
journal = "Pharmacy Education",
title = "Different approaches in pharmaceutical education: Comparison of three educational models",
volume = "2",
number = "4",
pages = "209-212",
doi = "10.1080/1560221021000061823"
}

Todorović, A., Karljiković-Rajić, K., Agbaba, D., Vukicević-Nikolić, N.,& Riley, T.N. (2002). Different approaches in pharmaceutical education: Comparison of three educational models. in Pharmacy Education
International Pharmaceutical Federation., 2(4), 209-212.
https://doi.org/10.1080/1560221021000061823

Todorović A, Karljiković-Rajić K, Agbaba D, Vukicević-Nikolić N, Riley T. Different approaches in pharmaceutical education: Comparison of three educational models. in Pharmacy Education. 2002;2(4):209-212.
doi:10.1080/1560221021000061823 .

Todorović, Aleksandar, Karljiković-Rajić, Katarina, Agbaba, Danica, Vukicević-Nikolić, N, Riley, T.N, "Different approaches in pharmaceutical education: Comparison of three educational models" in Pharmacy Education, 2, no. 4 (2002):209-212,
https://doi.org/10.1080/1560221021000061823 . .