TY  - JOUR
AU  - Radovanović, J
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Petrović, M
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/185
AB  - The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.
PB  - Medecine Et Hygiene, Geneva 4
T2  - European Journal of Drug Metabolism and Pharmacokinetics
T1  - An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets
VL  - 23
IS  - 1
SP  - 33
EP  - 40
DO  - 10.1007/BF03189824
ER  - 

@article{
author = "Radovanović, J and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Petrović, M",
year = "1998",
abstract = "The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.",
publisher = "Medecine Et Hygiene, Geneva 4",
journal = "European Journal of Drug Metabolism and Pharmacokinetics",
title = "An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets",
volume = "23",
number = "1",
pages = "33-40",
doi = "10.1007/BF03189824"
}

Radovanović, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Petrović, M.. (1998). An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets. in European Journal of Drug Metabolism and Pharmacokinetics
Medecine Et Hygiene, Geneva 4., 23(1), 33-40.
https://doi.org/10.1007/BF03189824

Radovanović J, Đurić Z, Jovanović M, Ibrić S, Petrović M. An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets. in European Journal of Drug Metabolism and Pharmacokinetics. 1998;23(1):33-40.
doi:10.1007/BF03189824 .

Radovanović, J, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Petrović, M, "An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets" in European Journal of Drug Metabolism and Pharmacokinetics, 23, no. 1 (1998):33-40,
https://doi.org/10.1007/BF03189824 . .