TY  - JOUR
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Rottinghaus, George E.
AU  - Kragović, Milan
AU  - Petković, Andela
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Mercurio, Mariano
AU  - de Gennaro, Bruno
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2929
AB  - In this study, organozeolites were prepared by treatment of the natural zeolites (clinoptilolite and phillipsite) with cetylpyridinium chloride (CP) equivalent to 50 and 100% of their external cation exchange capacities (ECEC). Organoclinoptilolites (ZCPs) and organophillipsites (PCPs) were characterized by FTIR spectroscopy, thermal analysis, determination of the point of zero charge and zeta potential. Adsorption of zearalenone (ZEN) by ZCPs and PCPs at pH 3 and 7 was investigated. Results showed that adsorption of ZEN increases with increasing amounts of CP at the zeolitic surfaces for both ZCPs and PCPs but the adsorption mechanism was different. Adsorption of ZEN by ZCPs followed a linear type of isotherm at pH 3 and 7 while ZEN adsorption by PCPs showed non linear (Langmuir and Freundlich) type of isotherm at both pH values. Different interactions between the ZEN molecule (or ion) and ZCPs and PCPs occurred: partition (linear isotherms) and adsorption in addition to partition (non linear isotherms), respectively. For the highest level of organic phase at the zeolitic surfaces, the maximum adsorbed amount of ZEN was 5.73 mg/g for organoclinoptilolite and 6.86 mg/g for organophillipsite at pH 3. Slightly higher adsorption: 6.98 mg/g for organoclinoptilolite and 7.54 mg/g for organophillipsite was achieved at pH 7. The results confirmed that CP ions at both zeolitic surfaces are responsible for ZEN adsorption and that organophillipsites are as effective in ZEN adsorption as organoclinoptilolites.
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant
VL  - 151
SP  - 324
EP  - 332
DO  - 10.1016/j.colsurfb.2016.12.033
ER  - 

@article{
author = "Marković, Marija and Daković, Aleksandra and Rottinghaus, George E. and Kragović, Milan and Petković, Andela and Krajišnik, Danina and Milić, Jela and Mercurio, Mariano and de Gennaro, Bruno",
year = "2017",
abstract = "In this study, organozeolites were prepared by treatment of the natural zeolites (clinoptilolite and phillipsite) with cetylpyridinium chloride (CP) equivalent to 50 and 100% of their external cation exchange capacities (ECEC). Organoclinoptilolites (ZCPs) and organophillipsites (PCPs) were characterized by FTIR spectroscopy, thermal analysis, determination of the point of zero charge and zeta potential. Adsorption of zearalenone (ZEN) by ZCPs and PCPs at pH 3 and 7 was investigated. Results showed that adsorption of ZEN increases with increasing amounts of CP at the zeolitic surfaces for both ZCPs and PCPs but the adsorption mechanism was different. Adsorption of ZEN by ZCPs followed a linear type of isotherm at pH 3 and 7 while ZEN adsorption by PCPs showed non linear (Langmuir and Freundlich) type of isotherm at both pH values. Different interactions between the ZEN molecule (or ion) and ZCPs and PCPs occurred: partition (linear isotherms) and adsorption in addition to partition (non linear isotherms), respectively. For the highest level of organic phase at the zeolitic surfaces, the maximum adsorbed amount of ZEN was 5.73 mg/g for organoclinoptilolite and 6.86 mg/g for organophillipsite at pH 3. Slightly higher adsorption: 6.98 mg/g for organoclinoptilolite and 7.54 mg/g for organophillipsite was achieved at pH 7. The results confirmed that CP ions at both zeolitic surfaces are responsible for ZEN adsorption and that organophillipsites are as effective in ZEN adsorption as organoclinoptilolites.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant",
volume = "151",
pages = "324-332",
doi = "10.1016/j.colsurfb.2016.12.033"
}

Marković, M., Daković, A., Rottinghaus, G. E., Kragović, M., Petković, A., Krajišnik, D., Milić, J., Mercurio, M.,& de Gennaro, B.. (2017). Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant. in Colloids and Surfaces B: Biointerfaces
Elsevier Science BV, Amsterdam., 151, 324-332.
https://doi.org/10.1016/j.colsurfb.2016.12.033

Marković M, Daković A, Rottinghaus GE, Kragović M, Petković A, Krajišnik D, Milić J, Mercurio M, de Gennaro B. Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant. in Colloids and Surfaces B: Biointerfaces. 2017;151:324-332.
doi:10.1016/j.colsurfb.2016.12.033 .

Marković, Marija, Daković, Aleksandra, Rottinghaus, George E., Kragović, Milan, Petković, Andela, Krajišnik, Danina, Milić, Jela, Mercurio, Mariano, de Gennaro, Bruno, "Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant" in Colloids and Surfaces B: Biointerfaces, 151 (2017):324-332,
https://doi.org/10.1016/j.colsurfb.2016.12.033 . .

TY  - JOUR
AU  - Bajuk-Bogdanović, Danica
AU  - Jović, Aleksandar
AU  - Nedić-Vasiljević, Bojana
AU  - Milojević-Rakić, Maja
AU  - Kragović, Milan
AU  - Krajišnik, Danina
AU  - Holclajtner-Antunović, Ivanka
AU  - Dondur, Vera
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2873
AB  - Tungstophosphoric acid and BEA zeolite composites were synthesized by wetness impregnation, followed by ultrasonication and calcination. Composites were characterized using Raman spectroscopy, thermal analysis and pH-dependent zeta potential. Spectroscopic measurements indicated the interaction of acid and the support by binding of polyanion terminal oxygens and BEA extra framework H+ via hydrogen bonds. Evaluation of prepared composites revealed their higher efficiency in nicosulfuron adsorption, in comparison to parent zeolite. All prepared composites showed excellent adsorption properties for pesticide removal in the range 12.1-25.8 mg of nicosulfuron per gram of investigated sample. Better adsorption capacity was found for sonicated samples in comparison to as-synthesized and calcined ones. It was found that the amount of polyanion in the composites and the extent of the particles surface charge are not crucial for the adsorption application, it is rather the uniformity of the zeolite surface coverage with the polyanion that is was more important.
PB  - Elsevier Science BV, Amsterdam
T2  - Materials Science and Engineering B: Advanced Functional Solid-State Materials
T1  - 12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal
VL  - 225
SP  - 60
EP  - 67
DO  - 10.1016/j.mseb.2017.08.011
ER  - 

@article{
author = "Bajuk-Bogdanović, Danica and Jović, Aleksandar and Nedić-Vasiljević, Bojana and Milojević-Rakić, Maja and Kragović, Milan and Krajišnik, Danina and Holclajtner-Antunović, Ivanka and Dondur, Vera",
year = "2017",
abstract = "Tungstophosphoric acid and BEA zeolite composites were synthesized by wetness impregnation, followed by ultrasonication and calcination. Composites were characterized using Raman spectroscopy, thermal analysis and pH-dependent zeta potential. Spectroscopic measurements indicated the interaction of acid and the support by binding of polyanion terminal oxygens and BEA extra framework H+ via hydrogen bonds. Evaluation of prepared composites revealed their higher efficiency in nicosulfuron adsorption, in comparison to parent zeolite. All prepared composites showed excellent adsorption properties for pesticide removal in the range 12.1-25.8 mg of nicosulfuron per gram of investigated sample. Better adsorption capacity was found for sonicated samples in comparison to as-synthesized and calcined ones. It was found that the amount of polyanion in the composites and the extent of the particles surface charge are not crucial for the adsorption application, it is rather the uniformity of the zeolite surface coverage with the polyanion that is was more important.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Materials Science and Engineering B: Advanced Functional Solid-State Materials",
title = "12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal",
volume = "225",
pages = "60-67",
doi = "10.1016/j.mseb.2017.08.011"
}

Bajuk-Bogdanović, D., Jović, A., Nedić-Vasiljević, B., Milojević-Rakić, M., Kragović, M., Krajišnik, D., Holclajtner-Antunović, I.,& Dondur, V.. (2017). 12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal. in Materials Science and Engineering B: Advanced Functional Solid-State Materials
Elsevier Science BV, Amsterdam., 225, 60-67.
https://doi.org/10.1016/j.mseb.2017.08.011

Bajuk-Bogdanović D, Jović A, Nedić-Vasiljević B, Milojević-Rakić M, Kragović M, Krajišnik D, Holclajtner-Antunović I, Dondur V. 12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal. in Materials Science and Engineering B: Advanced Functional Solid-State Materials. 2017;225:60-67.
doi:10.1016/j.mseb.2017.08.011 .

Bajuk-Bogdanović, Danica, Jović, Aleksandar, Nedić-Vasiljević, Bojana, Milojević-Rakić, Maja, Kragović, Milan, Krajišnik, Danina, Holclajtner-Antunović, Ivanka, Dondur, Vera, "12-Tungstophosphoric acid/BEA zeolite composites - Characterization and application for pesticide removal" in Materials Science and Engineering B: Advanced Functional Solid-State Materials, 225 (2017):60-67,
https://doi.org/10.1016/j.mseb.2017.08.011 . .

TY  - JOUR
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Rottinghaus, George E.
AU  - Petković, Andela
AU  - Kragović, Milan
AU  - Krajišnik, Danina
AU  - Milić, Jela
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2827
AB  - Benzalkonium chloride - BC (the mixture of alkylbenzyldimethylammonium chlorides containing the alkyl groups having chain lengths of C8 to C18 and benzyl functional group) was used as a surfactant for production of organozeolites (BZs). The natural zeolite - clinoptilolite was modified with three different levels (2, 5 and 10 mmol/100 g) of BC. FTIR spectroscopy, thermal analysis, zeta potential measurements, determination of the point of zero charge and BET were used to determine the quantity of the surfactant at the zeolitic surface. The main aim was to investigate adsorption properties of BZs towards ochratoxin A (OCHRA) and zearalenone (ZEN) under in vitro conditions. Results showed that adsorption of OCHRA and ZEN by BZs increased with increasing amounts of BC at the zeolitic surface but the adsorption mechanism was different. Adsorption of OCHRA by BZs followed nonlinear isotherms at pH 3 and 7, and higher adsorption capacity was observed at pH 3. This indicates that adsorption was dependent on the form of OCHRA in solution and that the sites at the uncovered zeolitic surface together with the surfactants contributed to OCHRA adsorption. Adsorption of ZEN by BZs showed linear isotherms at pH 3 and 7 and similar amounts were adsorbed at both pH values. This suggests that adsorption is practically independent of the form of ZEN in solution and that organic cations at the zeolitic surface are the active sites relevant for ZEN adsorption.
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces A: Physicochemical and Engineering Aspects
T1  - Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride
VL  - 529
SP  - 7
EP  - 17
DO  - 10.1016/j.colsurfa.2017.05.054
ER  - 

@article{
author = "Marković, Marija and Daković, Aleksandra and Rottinghaus, George E. and Petković, Andela and Kragović, Milan and Krajišnik, Danina and Milić, Jela",
year = "2017",
abstract = "Benzalkonium chloride - BC (the mixture of alkylbenzyldimethylammonium chlorides containing the alkyl groups having chain lengths of C8 to C18 and benzyl functional group) was used as a surfactant for production of organozeolites (BZs). The natural zeolite - clinoptilolite was modified with three different levels (2, 5 and 10 mmol/100 g) of BC. FTIR spectroscopy, thermal analysis, zeta potential measurements, determination of the point of zero charge and BET were used to determine the quantity of the surfactant at the zeolitic surface. The main aim was to investigate adsorption properties of BZs towards ochratoxin A (OCHRA) and zearalenone (ZEN) under in vitro conditions. Results showed that adsorption of OCHRA and ZEN by BZs increased with increasing amounts of BC at the zeolitic surface but the adsorption mechanism was different. Adsorption of OCHRA by BZs followed nonlinear isotherms at pH 3 and 7, and higher adsorption capacity was observed at pH 3. This indicates that adsorption was dependent on the form of OCHRA in solution and that the sites at the uncovered zeolitic surface together with the surfactants contributed to OCHRA adsorption. Adsorption of ZEN by BZs showed linear isotherms at pH 3 and 7 and similar amounts were adsorbed at both pH values. This suggests that adsorption is practically independent of the form of ZEN in solution and that organic cations at the zeolitic surface are the active sites relevant for ZEN adsorption.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
title = "Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride",
volume = "529",
pages = "7-17",
doi = "10.1016/j.colsurfa.2017.05.054"
}

Marković, M., Daković, A., Rottinghaus, G. E., Petković, A., Kragović, M., Krajišnik, D.,& Milić, J.. (2017). Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride. in Colloids and Surfaces A: Physicochemical and Engineering Aspects
Elsevier Science BV, Amsterdam., 529, 7-17.
https://doi.org/10.1016/j.colsurfa.2017.05.054

Marković M, Daković A, Rottinghaus GE, Petković A, Kragović M, Krajišnik D, Milić J. Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride. in Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2017;529:7-17.
doi:10.1016/j.colsurfa.2017.05.054 .

Marković, Marija, Daković, Aleksandra, Rottinghaus, George E., Petković, Andela, Kragović, Milan, Krajišnik, Danina, Milić, Jela, "Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride" in Colloids and Surfaces A: Physicochemical and Engineering Aspects, 529 (2017):7-17,
https://doi.org/10.1016/j.colsurfa.2017.05.054 . .

TY  - JOUR
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Krajišnik, Danina
AU  - Kragović, Milan
AU  - Milić, Jela
AU  - Langella, Alessio
AU  - de Gennaro, Bruno
AU  - Cappelletti, Piergiulio
AU  - Mercurio, Mariano
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2696
AB  - Incorporation of diclofenac sodium into phillipsite modified with cetylpyridinium chloride (CP-Cl) or hexadecyltrimethyl ammonium bromide (HDTMA-Br) was followed by batch equilibrium adsorption studies in buffer solution at pH = 7.4. Characteristics of the drug/surfactant/zeolite complexes were investigated by UV/VIS, FTIR spectroscopy, thermal (DTA/TG) analysis and-potential measurements. The obtained data confirmed that organic cations at phillipsite surface were responsible for incorporation of diclofenac sodium. Diclofenac sodium incorporated amounts increased with increasing the amount of each surfactant as well as with increasing the initial drug concentration. Langmuir model was the best model for fitting the experimental data of diclofenac adsorption on surfactant/phillipsite composites, suggesting complex adsorption mechanism. The physico-chemical properties of surfactant/phillipsite composites and enhanced incorporation of diclofenac sodium suggests that it might be possible to use these materials as drug carriers.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Molecular Liquids
T1  - Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium
VL  - 222
SP  - 711
EP  - 716
DO  - 10.1016/j.molliq.2016.07.127
ER  - 

@article{
author = "Marković, Marija and Daković, Aleksandra and Krajišnik, Danina and Kragović, Milan and Milić, Jela and Langella, Alessio and de Gennaro, Bruno and Cappelletti, Piergiulio and Mercurio, Mariano",
year = "2016",
abstract = "Incorporation of diclofenac sodium into phillipsite modified with cetylpyridinium chloride (CP-Cl) or hexadecyltrimethyl ammonium bromide (HDTMA-Br) was followed by batch equilibrium adsorption studies in buffer solution at pH = 7.4. Characteristics of the drug/surfactant/zeolite complexes were investigated by UV/VIS, FTIR spectroscopy, thermal (DTA/TG) analysis and-potential measurements. The obtained data confirmed that organic cations at phillipsite surface were responsible for incorporation of diclofenac sodium. Diclofenac sodium incorporated amounts increased with increasing the amount of each surfactant as well as with increasing the initial drug concentration. Langmuir model was the best model for fitting the experimental data of diclofenac adsorption on surfactant/phillipsite composites, suggesting complex adsorption mechanism. The physico-chemical properties of surfactant/phillipsite composites and enhanced incorporation of diclofenac sodium suggests that it might be possible to use these materials as drug carriers.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Molecular Liquids",
title = "Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium",
volume = "222",
pages = "711-716",
doi = "10.1016/j.molliq.2016.07.127"
}

Marković, M., Daković, A., Krajišnik, D., Kragović, M., Milić, J., Langella, A., de Gennaro, B., Cappelletti, P.,& Mercurio, M.. (2016). Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium. in Journal of Molecular Liquids
Elsevier Science BV, Amsterdam., 222, 711-716.
https://doi.org/10.1016/j.molliq.2016.07.127

Marković M, Daković A, Krajišnik D, Kragović M, Milić J, Langella A, de Gennaro B, Cappelletti P, Mercurio M. Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium. in Journal of Molecular Liquids. 2016;222:711-716.
doi:10.1016/j.molliq.2016.07.127 .

Marković, Marija, Daković, Aleksandra, Krajišnik, Danina, Kragović, Milan, Milić, Jela, Langella, Alessio, de Gennaro, Bruno, Cappelletti, Piergiulio, Mercurio, Mariano, "Evaluation of the surfactant/phillipsite composites as carriers for diclofenac sodium" in Journal of Molecular Liquids, 222 (2016):711-716,
https://doi.org/10.1016/j.molliq.2016.07.127 . .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Malenović, Anđelija
AU  - Kragović, Milan
AU  - Milić, Jela
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2327
AB  - The sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants - benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to similar to 40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms.
PB  - Mineralogical Soc, Twickenham
T2  - Clay Minerals
T1  - Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers
VL  - 50
IS  - 1
SP  - 11
EP  - 22
DO  - 10.1180/claymin.2015.050.1.02
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Kragović, Milan and Milić, Jela",
year = "2015",
abstract = "The sorption of ibuprofen by modified natural zeolite composites at three concentration levels (10, 20 and 30 mmol/100 g) of cationic surfactants - benzalkonium chloride and cetylpyridinium chloride, in a buffer solution (pH 7.4), was studied. Characterization of the composites before and after ibuprofen sorption was performed by drug sorption and isotherm studies, zeta potential and Fourier Transform infrared spectroscopic analysis. The biopharmaceutical performance of cationic surfactant-modified zeolites as drug formulation excipients was evaluated by in vitro dissolution experiments from the composites with medium surfactant contents. The drug sorption was influenced by the surfactant type and amount used for the zeolite modification. Prolonged drug release over a period of 8 h (up to similar to 40%) was achieved with both groups of samples. The kinetic analysis showed that the drug release profiles were best fitted with the Higuchi and the Bhaskar models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms.",
publisher = "Mineralogical Soc, Twickenham",
journal = "Clay Minerals",
title = "Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers",
volume = "50",
number = "1",
pages = "11-22",
doi = "10.1180/claymin.2015.050.1.02"
}

Krajišnik, D., Daković, A., Malenović, A., Kragović, M.,& Milić, J.. (2015). Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers. in Clay Minerals
Mineralogical Soc, Twickenham., 50(1), 11-22.
https://doi.org/10.1180/claymin.2015.050.1.02

Krajišnik D, Daković A, Malenović A, Kragović M, Milić J. Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers. in Clay Minerals. 2015;50(1):11-22.
doi:10.1180/claymin.2015.050.1.02 .

Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Kragović, Milan, Milić, Jela, "Ibuprofen sorption and release by modified natural zeolites as prospective drug carriers" in Clay Minerals, 50, no. 1 (2015):11-22,
https://doi.org/10.1180/claymin.2015.050.1.02 . .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Malenović, Anđelija
AU  - Đekić, Ljiljana
AU  - Kragović, Milan
AU  - Dobričić, Vladimir
AU  - Milić, Jela
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1959
AB  - In this paper, investigations of zeolite - cationic surfactant - drug composites as drug carriers were performed. For that purpose, after adsorption of the model drug - diclofenac sodium (DS) onto composites obtained by the modification of natural zeolite (NZ) with cetylpyridinium chloride (CPC) at the three different levels, i.e., 10, 20 and 30 mmol/100 g (ZCPC-10, ZCPC-20 and ZCPC-30, respectively), the release of the drug, at pH 6.8, was studied. The results of DS release from ZCPC-10 composite (DS/ZCPC-10) were compared with the DS release from corresponding physical mixture, as well as from physical mixture of NZ and DS. Characterization of the composites after adsorption of DS and the physical mixtures was realized by zeta potential measurements and by thermal analysis. Results showed that the prolonged release of DS from all the three composites, as well as from physical mixture containing ZCPC-10 and DS was achieved over a period of 8 h. The drug release from both DS/ZCPC-10 (max 55%) and corresponding physical mixture (max 38%) was remarkably lower than that from the physical mixture of NZ and DS (max 85%). The kinetic analysis for all the three composites, as well as for the physical mixture of ZCPC-10 and DS, showed that drug release profiles were best fitted with the Korsmeyer-Peppas and Bhaskar release models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms in the dissolution medium.
PB  - Elsevier Science BV, Amsterdam
T2  - Microporous and Mesoporous Materials
T1  - An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient
VL  - 167
SP  - 94
EP  - 101
DO  - 10.1016/j.micromeso.2012.03.033
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Malenović, Anđelija and Đekić, Ljiljana and Kragović, Milan and Dobričić, Vladimir and Milić, Jela",
year = "2013",
abstract = "In this paper, investigations of zeolite - cationic surfactant - drug composites as drug carriers were performed. For that purpose, after adsorption of the model drug - diclofenac sodium (DS) onto composites obtained by the modification of natural zeolite (NZ) with cetylpyridinium chloride (CPC) at the three different levels, i.e., 10, 20 and 30 mmol/100 g (ZCPC-10, ZCPC-20 and ZCPC-30, respectively), the release of the drug, at pH 6.8, was studied. The results of DS release from ZCPC-10 composite (DS/ZCPC-10) were compared with the DS release from corresponding physical mixture, as well as from physical mixture of NZ and DS. Characterization of the composites after adsorption of DS and the physical mixtures was realized by zeta potential measurements and by thermal analysis. Results showed that the prolonged release of DS from all the three composites, as well as from physical mixture containing ZCPC-10 and DS was achieved over a period of 8 h. The drug release from both DS/ZCPC-10 (max 55%) and corresponding physical mixture (max 38%) was remarkably lower than that from the physical mixture of NZ and DS (max 85%). The kinetic analysis for all the three composites, as well as for the physical mixture of ZCPC-10 and DS, showed that drug release profiles were best fitted with the Korsmeyer-Peppas and Bhaskar release models, indicating a combination of drug diffusion and ion exchange as the predominant release mechanisms in the dissolution medium.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Microporous and Mesoporous Materials",
title = "An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient",
volume = "167",
pages = "94-101",
doi = "10.1016/j.micromeso.2012.03.033"
}

Krajišnik, D., Daković, A., Malenović, A., Đekić, L., Kragović, M., Dobričić, V.,& Milić, J.. (2013). An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient. in Microporous and Mesoporous Materials
Elsevier Science BV, Amsterdam., 167, 94-101.
https://doi.org/10.1016/j.micromeso.2012.03.033

Krajišnik D, Daković A, Malenović A, Đekić L, Kragović M, Dobričić V, Milić J. An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient. in Microporous and Mesoporous Materials. 2013;167:94-101.
doi:10.1016/j.micromeso.2012.03.033 .

Krajišnik, Danina, Daković, Aleksandra, Malenović, Anđelija, Đekić, Ljiljana, Kragović, Milan, Dobričić, Vladimir, Milić, Jela, "An investigation of diclofenac sodium release from cetylpyridinium chloride-modified natural zeolite as a pharmaceutical excipient" in Microporous and Mesoporous Materials, 167 (2013):94-101,
https://doi.org/10.1016/j.micromeso.2012.03.033 . .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Milojević, Maja
AU  - Malenović, Anđelija
AU  - Kragović, Milan
AU  - Bajuk-Bogdanović, Danica
AU  - Dondur, Vera
AU  - Milić, Jela
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1541
AB  - In this study an investigation of a model drug sorption onto cationic surfactant-modified natural zeolites as a drug formulation excipient was performed. Natural zeolite was modified with cetylpyridinium chloride in amounts equivalent to 100, 200 and 300% of its external cation-exchange capacity. The starting material and obtained organozeolites were characterized by Fourier transform infrared spectroscopy, zeta potential measurements and thermal analysis. In vitro sorption of diclofenac sodium as a model drug was studied for all surfactant/zeolite composites by means of sorption isotherm measurements in aqueous solutions (pH 7.4). The modified zeolites with three levels of surfactant coverage within the short activation time were prepared. Zeta potential measurements and thermal analysis showed that when the surfactant loading level was equal to external cation-exchange value, almost monolayer of organic phase were present at the zeolitic surface while higher amounts of surfactant produced less extended bilayers, ordered bilayers or admicelles at the zeolitic surface. Modified zeolites, obtained in this manner, were effective in diclofenac sodium sorption and the organic phase derived from adsorbed cetylpyridinium chloride was the primary sorption phase for the model drug. The Langmuir isotherm was found to describe the equilibrium sorption data well over the entire concentration range. The separate contributions of the adsorption and partition to the total sorption of DS were analyzed mathematically. Results revealed that that adsorption and partitioning of the model drug take place simultaneously.
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride
VL  - 83
IS  - 1
SP  - 165
EP  - 172
DO  - 10.1016/j.colsurfb.2010.11.024
ER  - 

@article{
author = "Krajišnik, Danina and Daković, Aleksandra and Milojević, Maja and Malenović, Anđelija and Kragović, Milan and Bajuk-Bogdanović, Danica and Dondur, Vera and Milić, Jela",
year = "2011",
abstract = "In this study an investigation of a model drug sorption onto cationic surfactant-modified natural zeolites as a drug formulation excipient was performed. Natural zeolite was modified with cetylpyridinium chloride in amounts equivalent to 100, 200 and 300% of its external cation-exchange capacity. The starting material and obtained organozeolites were characterized by Fourier transform infrared spectroscopy, zeta potential measurements and thermal analysis. In vitro sorption of diclofenac sodium as a model drug was studied for all surfactant/zeolite composites by means of sorption isotherm measurements in aqueous solutions (pH 7.4). The modified zeolites with three levels of surfactant coverage within the short activation time were prepared. Zeta potential measurements and thermal analysis showed that when the surfactant loading level was equal to external cation-exchange value, almost monolayer of organic phase were present at the zeolitic surface while higher amounts of surfactant produced less extended bilayers, ordered bilayers or admicelles at the zeolitic surface. Modified zeolites, obtained in this manner, were effective in diclofenac sodium sorption and the organic phase derived from adsorbed cetylpyridinium chloride was the primary sorption phase for the model drug. The Langmuir isotherm was found to describe the equilibrium sorption data well over the entire concentration range. The separate contributions of the adsorption and partition to the total sorption of DS were analyzed mathematically. Results revealed that that adsorption and partitioning of the model drug take place simultaneously.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride",
volume = "83",
number = "1",
pages = "165-172",
doi = "10.1016/j.colsurfb.2010.11.024"
}

Krajišnik, D., Daković, A., Milojević, M., Malenović, A., Kragović, M., Bajuk-Bogdanović, D., Dondur, V.,& Milić, J.. (2011). Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride. in Colloids and Surfaces B: Biointerfaces
Elsevier Science BV, Amsterdam., 83(1), 165-172.
https://doi.org/10.1016/j.colsurfb.2010.11.024

Krajišnik D, Daković A, Milojević M, Malenović A, Kragović M, Bajuk-Bogdanović D, Dondur V, Milić J. Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride. in Colloids and Surfaces B: Biointerfaces. 2011;83(1):165-172.
doi:10.1016/j.colsurfb.2010.11.024 .

Krajišnik, Danina, Daković, Aleksandra, Milojević, Maja, Malenović, Anđelija, Kragović, Milan, Bajuk-Bogdanović, Danica, Dondur, Vera, Milić, Jela, "Properties of diclofenac sodium sorption onto natural zeolite modified with cetylpyridinium chloride" in Colloids and Surfaces B: Biointerfaces, 83, no. 1 (2011):165-172,
https://doi.org/10.1016/j.colsurfb.2010.11.024 . .