TY  - JOUR
AU  - Gojković-Bukarica, Ljiljana
AU  - Beleslin-Cokić, Bojana B.
AU  - Novaković, Aleksandra
AU  - Perić, Miodrag
AU  - Marković-Lipkovski, Jasmina
AU  - Cirović, Sanja Z.
AU  - Nezić, Dušan
AU  - Lesić, Aleksandar R.
AU  - Kanjuh, Vladimir
AU  - Heinle, Helmut
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1571
AB  - Because adrenergic contractions can contribute to the development of life-threatening spasm of coronary artery bypass graft, this study was performed to investigate the effect of adenosine 3-phosphate (ATP)-sensitive K(+) channel (K(ATP)) opener P1075 on contractions of isolated human saphenous vein (HSV) and human internal mammary artery (HIMA). Phasic contractions were evoked by electric field stimulation (20 Hz) and noradrenaline. The sustained contractions were evoked by phenylephrine. The presence of pore-forming Kir6.1 and Kir6.2 subunits of the K(ATP) channels in the HIMA and only Kir6.2 in the HSV was confirmed immunomorphologically. P1075 inhibited in the HSV only, the electrical field stimulation contractions more strongly than noradrenaline contractions. In addition, the phenylephrine contractions of HSV were more sensitive to P1075 in comparison to those of HIMA. Glibenclamide, a K(ATP) channel blocker antagonized the vasodilatation produced by P1075 in both grafts differently, because its effect was more prominent on the P1075-induced inhibition of contractions of HSV than of HIMA. We conclude that P1075 has a vasorelaxant effect and inhibited adrenergic contractions of the tested grafts. This effect is graft and vasoconstrictor selective and seems to be mediated by Kir6.1-and/or Kir6.2-containing K(ATP) channels. Thus, P1075 can be considered as a potential drug in the prevention of graft spasm.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Cardiovascular Pharmacology
T1  - The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery
VL  - 57
IS  - 6
SP  - 648
EP  - 655
DO  - 10.1097/FJC.0b013e3182145850
ER  - 

@article{
author = "Gojković-Bukarica, Ljiljana and Beleslin-Cokić, Bojana B. and Novaković, Aleksandra and Perić, Miodrag and Marković-Lipkovski, Jasmina and Cirović, Sanja Z. and Nezić, Dušan and Lesić, Aleksandar R. and Kanjuh, Vladimir and Heinle, Helmut",
year = "2011",
abstract = "Because adrenergic contractions can contribute to the development of life-threatening spasm of coronary artery bypass graft, this study was performed to investigate the effect of adenosine 3-phosphate (ATP)-sensitive K(+) channel (K(ATP)) opener P1075 on contractions of isolated human saphenous vein (HSV) and human internal mammary artery (HIMA). Phasic contractions were evoked by electric field stimulation (20 Hz) and noradrenaline. The sustained contractions were evoked by phenylephrine. The presence of pore-forming Kir6.1 and Kir6.2 subunits of the K(ATP) channels in the HIMA and only Kir6.2 in the HSV was confirmed immunomorphologically. P1075 inhibited in the HSV only, the electrical field stimulation contractions more strongly than noradrenaline contractions. In addition, the phenylephrine contractions of HSV were more sensitive to P1075 in comparison to those of HIMA. Glibenclamide, a K(ATP) channel blocker antagonized the vasodilatation produced by P1075 in both grafts differently, because its effect was more prominent on the P1075-induced inhibition of contractions of HSV than of HIMA. We conclude that P1075 has a vasorelaxant effect and inhibited adrenergic contractions of the tested grafts. This effect is graft and vasoconstrictor selective and seems to be mediated by Kir6.1-and/or Kir6.2-containing K(ATP) channels. Thus, P1075 can be considered as a potential drug in the prevention of graft spasm.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Cardiovascular Pharmacology",
title = "The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery",
volume = "57",
number = "6",
pages = "648-655",
doi = "10.1097/FJC.0b013e3182145850"
}

Gojković-Bukarica, L., Beleslin-Cokić, B. B., Novaković, A., Perić, M., Marković-Lipkovski, J., Cirović, S. Z., Nezić, D., Lesić, A. R., Kanjuh, V.,& Heinle, H.. (2011). The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery. in Journal of Cardiovascular Pharmacology
Lippincott Williams & Wilkins, Philadelphia., 57(6), 648-655.
https://doi.org/10.1097/FJC.0b013e3182145850

Gojković-Bukarica L, Beleslin-Cokić BB, Novaković A, Perić M, Marković-Lipkovski J, Cirović SZ, Nezić D, Lesić AR, Kanjuh V, Heinle H. The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery. in Journal of Cardiovascular Pharmacology. 2011;57(6):648-655.
doi:10.1097/FJC.0b013e3182145850 .

Gojković-Bukarica, Ljiljana, Beleslin-Cokić, Bojana B., Novaković, Aleksandra, Perić, Miodrag, Marković-Lipkovski, Jasmina, Cirović, Sanja Z., Nezić, Dušan, Lesić, Aleksandar R., Kanjuh, Vladimir, Heinle, Helmut, "The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery" in Journal of Cardiovascular Pharmacology, 57, no. 6 (2011):648-655,
https://doi.org/10.1097/FJC.0b013e3182145850 . .

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Perić, Miodrag
AU  - Nezić, Dušan
AU  - Kanjuh, Vladimir
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1397
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Circulation
T1  - The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein
VL  - 122
IS  - 2
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1397
ER  - 

@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Perić, Miodrag and Nezić, Dušan and Kanjuh, Vladimir",
year = "2010",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Circulation",
title = "The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein",
volume = "122",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1397"
}

Novaković, A., Gojković-Bukarica, L., Perić, M., Nezić, D.,& Kanjuh, V.. (2010). The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein. in Circulation
Lippincott Williams & Wilkins, Philadelphia., 122(2).
https://hdl.handle.net/21.15107/rcub_farfar_1397

Novaković A, Gojković-Bukarica L, Perić M, Nezić D, Kanjuh V. The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein. in Circulation. 2010;122(2).
https://hdl.handle.net/21.15107/rcub_farfar_1397 .

Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Perić, Miodrag, Nezić, Dušan, Kanjuh, Vladimir, "The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein" in Circulation, 122, no. 2 (2010),
https://hdl.handle.net/21.15107/rcub_farfar_1397 .