@article{
author = "Kundaković, Tatjana and Milenković, Marina and Zlatković, Sasa and Nikolić, Vesna D. and Nikolić, Goran and Binić, Ivana",
year = "2012",
abstract = "Background: Venous ulcers (ulcus cruris venosum) are a common chronic disease that requires continuing treatment and significantly influences a patient's way of life. The therapeutic effects of the ointment Herbadermal on epithelialization and microbial flora of venous ulcers in 25 patients (10 men and 15 women) were tested over a 7-week period. The major components of the ointment are extracts of garlic, St. John's wort, and calendula. Material and Methods: The patients were over 18 years of age, with ulceration of the lower leg no longer than 2 months or recurrent ulceration during the last 6 months. The involved patients did not use any other phytomedicines or supportive therapies. Parameters were evaluated before the treatment and every 2 weeks during the period of 7 weeks. The total treatment response was evaluated on the basis of epithelialization, granulation, fibrin deposits, exudation, and edema. Results: The percentage of epithelialization was 99.1% after 7 weeks, without significant effects on the microbial flora. Conclusion: This combination of extracts can be recommended as topical treatment for wound healing because of its epithelizing, anti-erythematous, and anti-edematous properties.",
publisher = "Karger, Basel",
journal = "Forschende Komplementarmedizin",
title = "Treatment of Venous Ulcers with the Herbal-Based Ointment Herbadermal (R): A Prospective Non-Randomized Pilot Study",
volume = "19",
number = "1",
pages = "26-30",
doi = "10.1159/000335786"
}