TY  - JOUR
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Cerne, Darko
AU  - Zupan, Janja
AU  - Marc, Janja
AU  - Vujić, Zorica
AU  - Crevar-Sakač, Milkica
AU  - Sopić, Miron
AU  - Munjas, Jelena
AU  - Radenković, Miroslav
AU  - Jelić-Ivanović, Zorana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3189
AB  - Context: Polyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage. Objectives: We examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta [haemeoxygenase-1 (HO1), haemeoxygenase-2 (HO2), NADPH oxidase 4 (NOX-4), monocyte chemoattractant protein-1 (MCP-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)]. Materials and methods: Eighteen male Wistar albino rats were divided into three groups (n=6/group): The control group (CG) was fed with standard pellet chow for 11 weeks; the AD group was fed for a similar period of time with pellet chow supplemented with 2% cholesterol, 3% sunflower oil and 1% sodium cholate. The ADA group was fed with pellet chow (for 1 week), the atherogenic diet (see above) for the following 4 weeks and then with ALT (0.1 mL/kg body weight) and atherogenic diet for 6 weeks. According to HPLC analysis, the isolated main compounds in ALT were chlorogenic acid, caffeic acid, isoquercitrin and rutin. Results: Normalized HO-1 [0.11 (0.04-0.24)] and MCP-1 [0.29 (0.21-0.47)] mRNA levels and DNA scores [12.50 (4.50-36.50)] were significantly lower in the ADA group than in the AD group [0.84 (0.35-2.51)], p = 0.021 for HO-1 [0.85 (0.61-3.45)], p = 0.047 for MCP-1 and [176.5 (66.50-221.25)], p = 0.020 for DNA scores. HO-1 mRNA was lower in the ADA group than in the CG group [0.30 (0.21-0.71), p = 0.049]. Conclusions: Supplementation with ALT limited the effects of the atherogenic diet through reduced MCP-1 expression, thereby preventing oxidative damage.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Pharmaceutical Biology
T1  - The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet
VL  - 56
IS  - 1
SP  - 138
EP  - 144
DO  - 10.1080/13880209.2018.1434549
ER  - 

@article{
author = "Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Cerne, Darko and Zupan, Janja and Marc, Janja and Vujić, Zorica and Crevar-Sakač, Milkica and Sopić, Miron and Munjas, Jelena and Radenković, Miroslav and Jelić-Ivanović, Zorana",
year = "2018",
abstract = "Context: Polyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage. Objectives: We examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta [haemeoxygenase-1 (HO1), haemeoxygenase-2 (HO2), NADPH oxidase 4 (NOX-4), monocyte chemoattractant protein-1 (MCP-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2)]. Materials and methods: Eighteen male Wistar albino rats were divided into three groups (n=6/group): The control group (CG) was fed with standard pellet chow for 11 weeks; the AD group was fed for a similar period of time with pellet chow supplemented with 2% cholesterol, 3% sunflower oil and 1% sodium cholate. The ADA group was fed with pellet chow (for 1 week), the atherogenic diet (see above) for the following 4 weeks and then with ALT (0.1 mL/kg body weight) and atherogenic diet for 6 weeks. According to HPLC analysis, the isolated main compounds in ALT were chlorogenic acid, caffeic acid, isoquercitrin and rutin. Results: Normalized HO-1 [0.11 (0.04-0.24)] and MCP-1 [0.29 (0.21-0.47)] mRNA levels and DNA scores [12.50 (4.50-36.50)] were significantly lower in the ADA group than in the AD group [0.84 (0.35-2.51)], p = 0.021 for HO-1 [0.85 (0.61-3.45)], p = 0.047 for MCP-1 and [176.5 (66.50-221.25)], p = 0.020 for DNA scores. HO-1 mRNA was lower in the ADA group than in the CG group [0.30 (0.21-0.71), p = 0.049]. Conclusions: Supplementation with ALT limited the effects of the atherogenic diet through reduced MCP-1 expression, thereby preventing oxidative damage.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Pharmaceutical Biology",
title = "The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet",
volume = "56",
number = "1",
pages = "138-144",
doi = "10.1080/13880209.2018.1434549"
}

Bogavac-Stanojević, N., Kotur-Stevuljević, J., Cerne, D., Zupan, J., Marc, J., Vujić, Z., Crevar-Sakač, M., Sopić, M., Munjas, J., Radenković, M.,& Jelić-Ivanović, Z.. (2018). The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet. in Pharmaceutical Biology
Taylor & Francis Ltd, Abingdon., 56(1), 138-144.
https://doi.org/10.1080/13880209.2018.1434549

Bogavac-Stanojević N, Kotur-Stevuljević J, Cerne D, Zupan J, Marc J, Vujić Z, Crevar-Sakač M, Sopić M, Munjas J, Radenković M, Jelić-Ivanović Z. The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet. in Pharmaceutical Biology. 2018;56(1):138-144.
doi:10.1080/13880209.2018.1434549 .

Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Cerne, Darko, Zupan, Janja, Marc, Janja, Vujić, Zorica, Crevar-Sakač, Milkica, Sopić, Miron, Munjas, Jelena, Radenković, Miroslav, Jelić-Ivanović, Zorana, "The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet" in Pharmaceutical Biology, 56, no. 1 (2018):138-144,
https://doi.org/10.1080/13880209.2018.1434549 . .

TY  - JOUR
AU  - Erić, Slavica
AU  - Solmajer, Tom
AU  - Zupan, Janja
AU  - Nović, M
AU  - Oblak, M
AU  - Agbaba, Danica
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/560
AB  - A quantitative structure-selectivity relationships of series of structurally diverse α 1 -adrenergic antagonists was performed by using counter-propagation neural network (CP-ANN). The theoretical molecular descriptors have been calculated and selected using CODESSA program. The results obtained for a highly non-congeneric set of molecules have confirmed the potential of use of CP-ANN approach in prediction of relative activity (selectivity) of α 1 -adrenergic antagonists.
PB  - Elsevier Masson SAS
T2  - Farmaco
T1  - Prediction of selectivity of α 1 -adrenergic antagonists by counterpropagation neural network (CP-ANN)
VL  - 59
IS  - 5
SP  - 389
EP  - 395
DO  - 10.1016/j.farmac.2003.12.009
ER  - 

@article{
author = "Erić, Slavica and Solmajer, Tom and Zupan, Janja and Nović, M and Oblak, M and Agbaba, Danica",
year = "2004",
abstract = "A quantitative structure-selectivity relationships of series of structurally diverse α 1 -adrenergic antagonists was performed by using counter-propagation neural network (CP-ANN). The theoretical molecular descriptors have been calculated and selected using CODESSA program. The results obtained for a highly non-congeneric set of molecules have confirmed the potential of use of CP-ANN approach in prediction of relative activity (selectivity) of α 1 -adrenergic antagonists.",
publisher = "Elsevier Masson SAS",
journal = "Farmaco",
title = "Prediction of selectivity of α 1 -adrenergic antagonists by counterpropagation neural network (CP-ANN)",
volume = "59",
number = "5",
pages = "389-395",
doi = "10.1016/j.farmac.2003.12.009"
}

Erić, S., Solmajer, T., Zupan, J., Nović, M., Oblak, M.,& Agbaba, D.. (2004). Prediction of selectivity of α 1 -adrenergic antagonists by counterpropagation neural network (CP-ANN). in Farmaco
Elsevier Masson SAS., 59(5), 389-395.
https://doi.org/10.1016/j.farmac.2003.12.009

Erić S, Solmajer T, Zupan J, Nović M, Oblak M, Agbaba D. Prediction of selectivity of α 1 -adrenergic antagonists by counterpropagation neural network (CP-ANN). in Farmaco. 2004;59(5):389-395.
doi:10.1016/j.farmac.2003.12.009 .

Erić, Slavica, Solmajer, Tom, Zupan, Janja, Nović, M, Oblak, M, Agbaba, Danica, "Prediction of selectivity of α 1 -adrenergic antagonists by counterpropagation neural network (CP-ANN)" in Farmaco, 59, no. 5 (2004):389-395,
https://doi.org/10.1016/j.farmac.2003.12.009 . .

TY  - JOUR
AU  - Erić, Slavica
AU  - Solmajer, Tom
AU  - Zupan, Janja
AU  - Nović, M
AU  - Oblak, M
AU  - Agbaba, Danica
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/495
AB  - A quantitative structure-activity relationship study with respect to selectivity for alpha(1) adrenoreceptor subtypes (alpha(1a), alpha(1b) and alpha(1d)) of a wide series of structurally heterogeneous alpha(1) adrenoreceptor antagonists has been performed. A large variety of molecular descriptors have been calculated and then analyzed by a heuristic method. The orthogonalization of the descriptors has been applied to build the QSAR equations. Ad hoc defined shape descriptors calculated by the Connolly algorithm with respect to reference supermolecules have also been considered in the rationalization of the mechanism of the activity of the ligands acting as antagonists on all three subtypes of alpha(1) adrenoreceptors.
PB  - Springer-Verlag, New York
T2  - Journal of Molecular Modeling
T1  - Quantitative structure-activity relationships of alpha(1) adrenergic antagonists
VL  - 10
IS  - 2
SP  - 139
EP  - 150
DO  - 10.1007/s00894-003-0177-2
ER  - 

@article{
author = "Erić, Slavica and Solmajer, Tom and Zupan, Janja and Nović, M and Oblak, M and Agbaba, Danica",
year = "2004",
abstract = "A quantitative structure-activity relationship study with respect to selectivity for alpha(1) adrenoreceptor subtypes (alpha(1a), alpha(1b) and alpha(1d)) of a wide series of structurally heterogeneous alpha(1) adrenoreceptor antagonists has been performed. A large variety of molecular descriptors have been calculated and then analyzed by a heuristic method. The orthogonalization of the descriptors has been applied to build the QSAR equations. Ad hoc defined shape descriptors calculated by the Connolly algorithm with respect to reference supermolecules have also been considered in the rationalization of the mechanism of the activity of the ligands acting as antagonists on all three subtypes of alpha(1) adrenoreceptors.",
publisher = "Springer-Verlag, New York",
journal = "Journal of Molecular Modeling",
title = "Quantitative structure-activity relationships of alpha(1) adrenergic antagonists",
volume = "10",
number = "2",
pages = "139-150",
doi = "10.1007/s00894-003-0177-2"
}

Erić, S., Solmajer, T., Zupan, J., Nović, M., Oblak, M.,& Agbaba, D.. (2004). Quantitative structure-activity relationships of alpha(1) adrenergic antagonists. in Journal of Molecular Modeling
Springer-Verlag, New York., 10(2), 139-150.
https://doi.org/10.1007/s00894-003-0177-2

Erić S, Solmajer T, Zupan J, Nović M, Oblak M, Agbaba D. Quantitative structure-activity relationships of alpha(1) adrenergic antagonists. in Journal of Molecular Modeling. 2004;10(2):139-150.
doi:10.1007/s00894-003-0177-2 .

Erić, Slavica, Solmajer, Tom, Zupan, Janja, Nović, M, Oblak, M, Agbaba, Danica, "Quantitative structure-activity relationships of alpha(1) adrenergic antagonists" in Journal of Molecular Modeling, 10, no. 2 (2004):139-150,
https://doi.org/10.1007/s00894-003-0177-2 . .

TY  - CONF
AU  - Erić, Slavica
AU  - Solmajer, Tom
AU  - Zupan, Janja
AU  - Novič, M.
AU  - Oblak, M.
AU  - Agbaba, Danica
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/341
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Ligand design of selective alfa1-adrenergic antagonists
T1  - Dizajniranje liganada selektivnih alfa1-adrenergičkih antagonista
VL  - 52
IS  - 4
SP  - 428
EP  - 429
UR  - https://hdl.handle.net/21.15107/rcub_farfar_341
ER  - 

@conference{
author = "Erić, Slavica and Solmajer, Tom and Zupan, Janja and Novič, M. and Oblak, M. and Agbaba, Danica",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Ligand design of selective alfa1-adrenergic antagonists, Dizajniranje liganada selektivnih alfa1-adrenergičkih antagonista",
volume = "52",
number = "4",
pages = "428-429",
url = "https://hdl.handle.net/21.15107/rcub_farfar_341"
}

Erić, S., Solmajer, T., Zupan, J., Novič, M., Oblak, M.,& Agbaba, D.. (2002). Ligand design of selective alfa1-adrenergic antagonists. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 428-429.
https://hdl.handle.net/21.15107/rcub_farfar_341

Erić S, Solmajer T, Zupan J, Novič M, Oblak M, Agbaba D. Ligand design of selective alfa1-adrenergic antagonists. in Arhiv za farmaciju. 2002;52(4):428-429.
https://hdl.handle.net/21.15107/rcub_farfar_341 .

Erić, Slavica, Solmajer, Tom, Zupan, Janja, Novič, M., Oblak, M., Agbaba, Danica, "Ligand design of selective alfa1-adrenergic antagonists" in Arhiv za farmaciju, 52, no. 4 (2002):428-429,
https://hdl.handle.net/21.15107/rcub_farfar_341 .