TY  - JOUR
AU  - Ivković, Branka
AU  - Opačić, Dragan
AU  - Džudović, Boris
AU  - Crevar, Milkica
AU  - Gojković-Bukarica, Ljiljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4306
AB  - It is well known that the presence of different chemical groups in drug molecules influences their pharmacological properties. The aim of our study is to investigate whether newly synthesized derivatives of propafenone, with changes in benzyl moiety, have a different effect upon arrhythmia, compared to propafenone. 5OCl-PF and 5OF-PF are derivatives of propafenone with-Cl or –F substituent on the ortho position of the benzyl moiety. For verification of their antiarrhythmic effect, we used an in vivo rat model of aconitine-induced arrhythmia. 5OCl-PF speeded the appearance of supraventricular premature beats (SVPB) and death more than aconitine. All animals treated with 5OCl-PF developed ventricular premature beats in salvos (VPBS), bigeminies (VPBB) and paroxysmal ventricular tachycardia (PVT). 5OF-PF had a negative chronotropic effect and potentiated atrial excitability (more SVPB). It had a positive effect on the occurrence and onset time of supraventricular tachycardia, VPBS, and PVT. Based on the obtained results, it can be concluded that newly synthesized propafenone derivatives have no better antiarrhythmic effect than the parent compound. In the future, our research will be focused on the synthesis of different derivatives and examining their antiarrhythmic effects.
AB  - Dobro je poznato da prisustvo različitih hemijskih grupa u molekulima leka utiče na
njegova farmakološka svojstva. Cilj našeg istraživanja je ispitati da li novosintetisani derivati
propafenona, s promenama u benzilnoj grupi, imaju drugačiji efekat na aritmiju u odnosu na
propafenon. 5OCl-PF i 5OF-PF su derivati propafenona sa -Cl ili –F supstituentom na orto
položaju benzilnog dela. Za proveru njihovog antiaritmičnog efekta koristili smo in vivo model
na pacovima sa aritmijom izazvanom akonitinom. 5OCl-PF je ubrzao pojavu
supraventrikularnih prevremenih otkucaja (SVPB) i smrt više nego akonitin. Sve životinje
lečene sa 5OCl-PF razvile su ventrikularne prevremene otkucaje (VPBS i VPBB) i
paroksizmalnu ventrikularnu tahikardiju (PVT). 5OF-PF je imao negativan hronotropni efekat i
potencirao atrijalnu ekscitabilnost (više SVPB). Pozitivno je uticao na pojavu i vreme početka
supraventrikularne tahikardije, VPBS i PVT. Na osnovu dobijenih rezultata se može zaključiti
da novosintetisani derivati propafenona nemaju bolji antiaritmijski efekat od polaznog
jedinjenja. U budućnosti, istraživanje će biti usmereno ka sintezi hemijski drugačijih derivata i
ispitivanju njihovog antiaritmijskog efekta.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Antiarrhythmic effects of newly developed propafenone derivatives
T1  - Antiaritmički efekti novosintetisanih derivata
propafenona
VL  - 72
IS  - 4
SP  - 392
EP  - 412
DO  - 10.5937/arhfarm72-37114
ER  - 

@article{
author = "Ivković, Branka and Opačić, Dragan and Džudović, Boris and Crevar, Milkica and Gojković-Bukarica, Ljiljana",
year = "2022",
abstract = "It is well known that the presence of different chemical groups in drug molecules influences their pharmacological properties. The aim of our study is to investigate whether newly synthesized derivatives of propafenone, with changes in benzyl moiety, have a different effect upon arrhythmia, compared to propafenone. 5OCl-PF and 5OF-PF are derivatives of propafenone with-Cl or –F substituent on the ortho position of the benzyl moiety. For verification of their antiarrhythmic effect, we used an in vivo rat model of aconitine-induced arrhythmia. 5OCl-PF speeded the appearance of supraventricular premature beats (SVPB) and death more than aconitine. All animals treated with 5OCl-PF developed ventricular premature beats in salvos (VPBS), bigeminies (VPBB) and paroxysmal ventricular tachycardia (PVT). 5OF-PF had a negative chronotropic effect and potentiated atrial excitability (more SVPB). It had a positive effect on the occurrence and onset time of supraventricular tachycardia, VPBS, and PVT. Based on the obtained results, it can be concluded that newly synthesized propafenone derivatives have no better antiarrhythmic effect than the parent compound. In the future, our research will be focused on the synthesis of different derivatives and examining their antiarrhythmic effects., Dobro je poznato da prisustvo različitih hemijskih grupa u molekulima leka utiče na
njegova farmakološka svojstva. Cilj našeg istraživanja je ispitati da li novosintetisani derivati
propafenona, s promenama u benzilnoj grupi, imaju drugačiji efekat na aritmiju u odnosu na
propafenon. 5OCl-PF i 5OF-PF su derivati propafenona sa -Cl ili –F supstituentom na orto
položaju benzilnog dela. Za proveru njihovog antiaritmičnog efekta koristili smo in vivo model
na pacovima sa aritmijom izazvanom akonitinom. 5OCl-PF je ubrzao pojavu
supraventrikularnih prevremenih otkucaja (SVPB) i smrt više nego akonitin. Sve životinje
lečene sa 5OCl-PF razvile su ventrikularne prevremene otkucaje (VPBS i VPBB) i
paroksizmalnu ventrikularnu tahikardiju (PVT). 5OF-PF je imao negativan hronotropni efekat i
potencirao atrijalnu ekscitabilnost (više SVPB). Pozitivno je uticao na pojavu i vreme početka
supraventrikularne tahikardije, VPBS i PVT. Na osnovu dobijenih rezultata se može zaključiti
da novosintetisani derivati propafenona nemaju bolji antiaritmijski efekat od polaznog
jedinjenja. U budućnosti, istraživanje će biti usmereno ka sintezi hemijski drugačijih derivata i
ispitivanju njihovog antiaritmijskog efekta.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Antiarrhythmic effects of newly developed propafenone derivatives, Antiaritmički efekti novosintetisanih derivata
propafenona",
volume = "72",
number = "4",
pages = "392-412",
doi = "10.5937/arhfarm72-37114"
}

Ivković, B., Opačić, D., Džudović, B., Crevar, M.,& Gojković-Bukarica, L.. (2022). Antiarrhythmic effects of newly developed propafenone derivatives. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 72(4), 392-412.
https://doi.org/10.5937/arhfarm72-37114

Ivković B, Opačić D, Džudović B, Crevar M, Gojković-Bukarica L. Antiarrhythmic effects of newly developed propafenone derivatives. in Arhiv za farmaciju. 2022;72(4):392-412.
doi:10.5937/arhfarm72-37114 .

Ivković, Branka, Opačić, Dragan, Džudović, Boris, Crevar, Milkica, Gojković-Bukarica, Ljiljana, "Antiarrhythmic effects of newly developed propafenone derivatives" in Arhiv za farmaciju, 72, no. 4 (2022):392-412,
https://doi.org/10.5937/arhfarm72-37114 . .

TY  - JOUR
AU  - Novaković, Radmila
AU  - Radunović, Nebojša
AU  - Rajković, Jovana
AU  - Đokić, Vladimir
AU  - Petrović, Aleksandar V.
AU  - Ivković, Branka
AU  - Ćupić, Vitomir
AU  - Kanjuh, Vladimir
AU  - Helmut, Heinlev
AU  - Gojković-Bukarica, Ljiljana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2769
AB  - Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions. Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol (1-100 μM),BaCl2 (1 mM),a antagonist of inwardly rectifying potassium channels was used. Resveratrol induced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels
VL  - 70
IS  - 3-4
SP  - 121
EP  - 129
DO  - 10.2298/VETGL1604121N
ER  - 

@article{
author = "Novaković, Radmila and Radunović, Nebojša and Rajković, Jovana and Đokić, Vladimir and Petrović, Aleksandar V. and Ivković, Branka and Ćupić, Vitomir and Kanjuh, Vladimir and Helmut, Heinlev and Gojković-Bukarica, Ljiljana",
year = "2016",
abstract = "Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions. Uterine strips were obtained from virgin female Wistar rats in oestrus. Strips were mounted into organ bath for recording isometric tension in Krebs-Ringer solution. Experiments followed a multiple curve design. In order to test the involvement of Kirchannels in a mechanism of action of resveratrol (1-100 μM),BaCl2 (1 mM),a antagonist of inwardly rectifying potassium channels was used. Resveratrol induced a concentration-dependent relaxation of all models of contractions. BaCl2 antagonized the response to resveratrolon SRC and oxytocin-elicited phasic contractions. Relaxation achieved by resveratrolon tonic oxytocin-elicited concentrations was insensitive to BaCl2.The antagonism of resveratrol effects by inwardly rectifying potassium channels antagonist suggests that Kir channels are involved in resveratrol action on phasic contractions of rat uterus. Inhibitory effect of resveratrol on tonic contractions did not include Kir channels.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels",
volume = "70",
number = "3-4",
pages = "121-129",
doi = "10.2298/VETGL1604121N"
}

Novaković, R., Radunović, N., Rajković, J., Đokić, V., Petrović, A. V., Ivković, B., Ćupić, V., Kanjuh, V., Helmut, H.,& Gojković-Bukarica, L.. (2016). Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 70(3-4), 121-129.
https://doi.org/10.2298/VETGL1604121N

Novaković R, Radunović N, Rajković J, Đokić V, Petrović AV, Ivković B, Ćupić V, Kanjuh V, Helmut H, Gojković-Bukarica L. Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels. in Veterinarski glasnik. 2016;70(3-4):121-129.
doi:10.2298/VETGL1604121N .

Novaković, Radmila, Radunović, Nebojša, Rajković, Jovana, Đokić, Vladimir, Petrović, Aleksandar V., Ivković, Branka, Ćupić, Vitomir, Kanjuh, Vladimir, Helmut, Heinlev, Gojković-Bukarica, Ljiljana, "Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels" in Veterinarski glasnik, 70, no. 3-4 (2016):121-129,
https://doi.org/10.2298/VETGL1604121N . .

TY  - JOUR
AU  - Novaković, Radmila
AU  - Radunović, Nebojša
AU  - Marković-Lipkovski, Jasmina
AU  - Cirović, S.
AU  - Beleslin-Cokić, Bojana B.
AU  - Ilić, B.
AU  - Ivković, Branka
AU  - Heinle, Helmut
AU  - Živanović, Vladimir
AU  - Gojković-Bukarica, Ljiljana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2462
AB  - The ideal agent for prevention and treatment of uterine abnormal contractility has not been found. The polyphenol resveratrol possesses a wide spectrum of pharmacologic properties, but its influence on the contractility of human myometrium is not defined. The present study evaluated the effect of resveratrol on the oxytocin-induced contractions of human term pregnant myometrium in vitro and the contribution of different K+ channels to resveratrol action. Resveratrol induced a concentration-dependent relaxation of myometrium contractions (pD(2) value and maximal responses were 4.52 and 82.25%, respectively). Glibenclamide, a selective blocker of ATP-sensitive (K-ATP), iberiotoxin, a selective blockers of big-calcium sensitive (BKCa) and 4-aminopiridine, a non-selective blocker of voltage-sensitive (Kv) channels induced a significant shift to the right of the concentration-response curves of resveratrol. Inhibition achieved by 0.1 mM resveratrol was insensitive to all K+ channel blockers. A K+ channel opener, pinacidil, inhibited oxytocin-induced contractions of pregnant myometrium with comparable potency and efficacy to resveratrol (pD(2) values and maximal relaxation were 4.52 and 83.67%, respectively). Based on K+ channel opener/blocker affinities, it appears that the inhibitory response of resveratrol involves different myometrial K+ channels. When applied in high concentrations, resveratrol has an additional K+-channel-independent mechanism(s) of action. Furthermore, immunohistochemistry staining and western blot analyses detected the presence and distribution of K-ATP, BKCa and Kv channel proteins in pregnant myometrium.
PB  - Oxford Univ Press, Oxford
T2  - Molecular Human Reproduction
T1  - Effects of the polyphenol resveratrol on contractility of human term pregnant myometrium
VL  - 21
IS  - 6
SP  - 545
EP  - 551
DO  - 10.1093/molehr/gav011
ER  - 

@article{
author = "Novaković, Radmila and Radunović, Nebojša and Marković-Lipkovski, Jasmina and Cirović, S. and Beleslin-Cokić, Bojana B. and Ilić, B. and Ivković, Branka and Heinle, Helmut and Živanović, Vladimir and Gojković-Bukarica, Ljiljana",
year = "2015",
abstract = "The ideal agent for prevention and treatment of uterine abnormal contractility has not been found. The polyphenol resveratrol possesses a wide spectrum of pharmacologic properties, but its influence on the contractility of human myometrium is not defined. The present study evaluated the effect of resveratrol on the oxytocin-induced contractions of human term pregnant myometrium in vitro and the contribution of different K+ channels to resveratrol action. Resveratrol induced a concentration-dependent relaxation of myometrium contractions (pD(2) value and maximal responses were 4.52 and 82.25%, respectively). Glibenclamide, a selective blocker of ATP-sensitive (K-ATP), iberiotoxin, a selective blockers of big-calcium sensitive (BKCa) and 4-aminopiridine, a non-selective blocker of voltage-sensitive (Kv) channels induced a significant shift to the right of the concentration-response curves of resveratrol. Inhibition achieved by 0.1 mM resveratrol was insensitive to all K+ channel blockers. A K+ channel opener, pinacidil, inhibited oxytocin-induced contractions of pregnant myometrium with comparable potency and efficacy to resveratrol (pD(2) values and maximal relaxation were 4.52 and 83.67%, respectively). Based on K+ channel opener/blocker affinities, it appears that the inhibitory response of resveratrol involves different myometrial K+ channels. When applied in high concentrations, resveratrol has an additional K+-channel-independent mechanism(s) of action. Furthermore, immunohistochemistry staining and western blot analyses detected the presence and distribution of K-ATP, BKCa and Kv channel proteins in pregnant myometrium.",
publisher = "Oxford Univ Press, Oxford",
journal = "Molecular Human Reproduction",
title = "Effects of the polyphenol resveratrol on contractility of human term pregnant myometrium",
volume = "21",
number = "6",
pages = "545-551",
doi = "10.1093/molehr/gav011"
}

Novaković, R., Radunović, N., Marković-Lipkovski, J., Cirović, S., Beleslin-Cokić, B. B., Ilić, B., Ivković, B., Heinle, H., Živanović, V.,& Gojković-Bukarica, L.. (2015). Effects of the polyphenol resveratrol on contractility of human term pregnant myometrium. in Molecular Human Reproduction
Oxford Univ Press, Oxford., 21(6), 545-551.
https://doi.org/10.1093/molehr/gav011

Novaković R, Radunović N, Marković-Lipkovski J, Cirović S, Beleslin-Cokić BB, Ilić B, Ivković B, Heinle H, Živanović V, Gojković-Bukarica L. Effects of the polyphenol resveratrol on contractility of human term pregnant myometrium. in Molecular Human Reproduction. 2015;21(6):545-551.
doi:10.1093/molehr/gav011 .

Novaković, Radmila, Radunović, Nebojša, Marković-Lipkovski, Jasmina, Cirović, S., Beleslin-Cokić, Bojana B., Ilić, B., Ivković, Branka, Heinle, Helmut, Živanović, Vladimir, Gojković-Bukarica, Ljiljana, "Effects of the polyphenol resveratrol on contractility of human term pregnant myometrium" in Molecular Human Reproduction, 21, no. 6 (2015):545-551,
https://doi.org/10.1093/molehr/gav011 . .

TY  - JOUR
AU  - Ivković, Branka
AU  - Gojković-Bukarica, Ljiljana
AU  - Novaković, Radmila
AU  - Ćupić, Vitomir
AU  - Vladimirov, Sote
AU  - Živanović, Vladimir
AU  - Šćepanović, Radisav
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2297
AB  - By applying of aconitictest in in vivo experiments in rats under deep anesthesia, there was investigated the antiarrhythmic potential of newly synthetized fluorinated derivatives of propafenone. The animals were divided into four experimental groups. The first (aconitine group) was treated with aconitine at a dose of 60 μg/kg, which led to pronounced cardiac rhythm disorder in a short period of time. The appearance of ventricular extrasystole (VES) was taken as a parameter for ascertainment of cardiac rhytm disorder. The remaining three animal groups were taken for testing the potential of propafenone and propafenone fluorinated derivatives to stop the arrhythmia, and which was induced by i.v. aconitine injection (60 μg/kg). Propafenone, as well as 50F derivative, did not convert the disturbed cardiac rhythm (survival of animals was 0%). By applying 5PF derivative in a dose of 6 mg/kg, the animals survived with occasional establishment of sinus rhythm.
AB  - Primenom akonitinskog testa, u in vivo eksperimentima na pacovima u dubokoj anesteziji, ispitivan je antiaritmijski potencijal novosintetisanih fluoriranih derivata propafenona. Životinje su podeljene u četiri eksperimentalne grupe. Prva grupa (akonitinska grupa) je tretirana akonitinom u dozi od 60 μg/kg t.m., koja dovodi do vidnog poremećaja srčanog ritma u kratkom vremenskom periodu. Kao parameter za registrovanje poremećaja srčanog ritma uzetaje pojava ventrikularne ekstrasistole (VES). Ostale (tri) eksperimentalne grupe činile su životinje na kojima je ispitivan potencijal propafenona i fluoriranih derivata propafenona da zaustave aritmiju indukovanu i.v. injekcijom akonitina (60 μg/kg t.m.). Propafenon, kao i 50F derivat, nisu uspeli da konvertuju poremećen srčani ritam (preživljavanje životinja je 0 %). Prilikom aplikacije 5PF derivata u dozi od 6 mg/kg t.m. životinje su preživele, uz povremeno uspostavljanje sinusnog ritma.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Veterinarski glasnik
T1  - Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats
T1  - Issledovanie antiaritmičeskoj aktivnosti vnov' sintezirovannyh proizvodnyh propafenona pri modelirovanii akonitovoi aritmii serdca u krys
T1  - Ispitivanje antiaritmijske aktivnosti novosintetisanih derivata propafenona u akonitinskom modelu srčane aritmije kod pacova
VL  - 68
IS  - 5-6
SP  - 281
EP  - 290
DO  - 10.2298/VETGL1406281I
ER  - 

@article{
author = "Ivković, Branka and Gojković-Bukarica, Ljiljana and Novaković, Radmila and Ćupić, Vitomir and Vladimirov, Sote and Živanović, Vladimir and Šćepanović, Radisav",
year = "2014",
abstract = "By applying of aconitictest in in vivo experiments in rats under deep anesthesia, there was investigated the antiarrhythmic potential of newly synthetized fluorinated derivatives of propafenone. The animals were divided into four experimental groups. The first (aconitine group) was treated with aconitine at a dose of 60 μg/kg, which led to pronounced cardiac rhythm disorder in a short period of time. The appearance of ventricular extrasystole (VES) was taken as a parameter for ascertainment of cardiac rhytm disorder. The remaining three animal groups were taken for testing the potential of propafenone and propafenone fluorinated derivatives to stop the arrhythmia, and which was induced by i.v. aconitine injection (60 μg/kg). Propafenone, as well as 50F derivative, did not convert the disturbed cardiac rhythm (survival of animals was 0%). By applying 5PF derivative in a dose of 6 mg/kg, the animals survived with occasional establishment of sinus rhythm., Primenom akonitinskog testa, u in vivo eksperimentima na pacovima u dubokoj anesteziji, ispitivan je antiaritmijski potencijal novosintetisanih fluoriranih derivata propafenona. Životinje su podeljene u četiri eksperimentalne grupe. Prva grupa (akonitinska grupa) je tretirana akonitinom u dozi od 60 μg/kg t.m., koja dovodi do vidnog poremećaja srčanog ritma u kratkom vremenskom periodu. Kao parameter za registrovanje poremećaja srčanog ritma uzetaje pojava ventrikularne ekstrasistole (VES). Ostale (tri) eksperimentalne grupe činile su životinje na kojima je ispitivan potencijal propafenona i fluoriranih derivata propafenona da zaustave aritmiju indukovanu i.v. injekcijom akonitina (60 μg/kg t.m.). Propafenon, kao i 50F derivat, nisu uspeli da konvertuju poremećen srčani ritam (preživljavanje životinja je 0 %). Prilikom aplikacije 5PF derivata u dozi od 6 mg/kg t.m. životinje su preživele, uz povremeno uspostavljanje sinusnog ritma.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Veterinarski glasnik",
title = "Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats, Issledovanie antiaritmičeskoj aktivnosti vnov' sintezirovannyh proizvodnyh propafenona pri modelirovanii akonitovoi aritmii serdca u krys, Ispitivanje antiaritmijske aktivnosti novosintetisanih derivata propafenona u akonitinskom modelu srčane aritmije kod pacova",
volume = "68",
number = "5-6",
pages = "281-290",
doi = "10.2298/VETGL1406281I"
}

Ivković, B., Gojković-Bukarica, L., Novaković, R., Ćupić, V., Vladimirov, S., Živanović, V.,& Šćepanović, R.. (2014). Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats. in Veterinarski glasnik
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 68(5-6), 281-290.
https://doi.org/10.2298/VETGL1406281I

Ivković B, Gojković-Bukarica L, Novaković R, Ćupić V, Vladimirov S, Živanović V, Šćepanović R. Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats. in Veterinarski glasnik. 2014;68(5-6):281-290.
doi:10.2298/VETGL1406281I .

Ivković, Branka, Gojković-Bukarica, Ljiljana, Novaković, Radmila, Ćupić, Vitomir, Vladimirov, Sote, Živanović, Vladimir, Šćepanović, Radisav, "Testing of newly synthesized propafenone derivatives antiarrhythmic activity in aconitic model of cardiac arrhythmia in rats" in Veterinarski glasnik, 68, no. 5-6 (2014):281-290,
https://doi.org/10.2298/VETGL1406281I . .

TY  - JOUR
AU  - Ivković, Branka
AU  - Gojković-Bukarica, Ljiljana
AU  - Vladimirov, S.
AU  - Novaković, Radmila
AU  - Ćupić, Vitomir
AU  - Lešić, A.
AU  - Bumbaširević, M.
AU  - Šćepanović, Radisav
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2063
AB  - The information on the inhibitory effect of propafenone in vascular smooth muscle is sparse. Propafenone acts through blockage of voltage-dependent cardiac Na+ channels, L-type Ca2+ channels, voltage-sensitive K+ (Kv) channels, as well as β-adrenergic receptors in the heart. The introduction of different chemical groups in the benzyl moiety of propafenone influences pharmacological properties of newly developed derivate of propafenone. Here we investigated the effect of new ortho-chloro derivate of propafenone (5OCl) on the vascular tone of precontracted rat aorta. 5OCl produced endothelium-independent relaxation of rat aorta. In order to test the involvement of different ion channels in 5OCl mechanism of action, antagonist of Na+, lidocaine, KV channels, 4-aminopyiridine (4-AP) and L-type Ca2+ channels, nifedipine were used. All tested antagonists of ion channels did not influence the relaxation of rat aorta induced by high a concentration of 5OCl (≥10 μM), but antagonized the relaxation induced by low concentrations of this propafenone derivate. Thus, 5OCl derivate has comparable potency and efficacy as propafenone. According to its interaction with lidocaine, 4-AP and nifedipine it seems that 5OCl partly shares the mechanism of action with propafenone. The mechanism of vasodilatation induced by high micromolar concentration of 5OCl is not defined and further investigations are necessary.
AB  - Informacije o efektima propafenona na vaskularne glatke mišiće su oskudne. Propafenon blokira voltažno-zavisne Na+ kanale, Ca2+ kanale L-tipa, voltažno-senzitivne K+ (Kv) kanale i β-adrenergičke receptore u srcu. Uvođenje različitih hemijskih grupa u benzilni deo molekula propafenona utiče na promenu njegovih farmakoloških osobina. U ovoj studiji je ispitivan uticaj novog orto-hloro derivata (5OCl) propafenona na vaskularni tonus prekontrahovane aorte pacova. Orto hlorni derivat (5OCl) je izazvao endotel-nezavisnu relaksaciju aortnih prstenova. Da bi se ispitala uloga različitih jonskih kanala u ovoj relaksaciji, korišćeni su lidokain, (antagonist Na+ kanala), 4-aminopiridin (antagonist Kv kanala) i nifedipin (antagonist Ca2+ kanala L-tipa). Testirani antagonisti jonskih kanala nisu uticali na relaksaciju aorte pacova izazvanu visokom koncentracijom 5OCl (≥10 μM), ali su zato antagonizovali relaksaciju aorte koncentracijama 5OCl koje su bile manje od 10 μM. Prema tome, 5OCl derivat ima sličnu jačinu i efikasnost kao propafenon. Prema njegovoj interakciji sa lidokainom, 4-AP i nifedipinom može se reći da je mehanizam dejstva 5OCl sličan propafenonu. Mehanizam vazodilatacije 5OCl derivata u koncentracijama većim od 10 μM nije definisan i za to su potrebna dalja istraživanja.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta
T1  - Relaksacija aorte pacova indukovana novosintetisanim orto-hlornim derivatom propafenona
VL  - 63
IS  - 4
SP  - 363
EP  - 371
DO  - 10.2298/AVB1304363I
ER  - 

@article{
author = "Ivković, Branka and Gojković-Bukarica, Ljiljana and Vladimirov, S. and Novaković, Radmila and Ćupić, Vitomir and Lešić, A. and Bumbaširević, M. and Šćepanović, Radisav",
year = "2013",
abstract = "The information on the inhibitory effect of propafenone in vascular smooth muscle is sparse. Propafenone acts through blockage of voltage-dependent cardiac Na+ channels, L-type Ca2+ channels, voltage-sensitive K+ (Kv) channels, as well as β-adrenergic receptors in the heart. The introduction of different chemical groups in the benzyl moiety of propafenone influences pharmacological properties of newly developed derivate of propafenone. Here we investigated the effect of new ortho-chloro derivate of propafenone (5OCl) on the vascular tone of precontracted rat aorta. 5OCl produced endothelium-independent relaxation of rat aorta. In order to test the involvement of different ion channels in 5OCl mechanism of action, antagonist of Na+, lidocaine, KV channels, 4-aminopyiridine (4-AP) and L-type Ca2+ channels, nifedipine were used. All tested antagonists of ion channels did not influence the relaxation of rat aorta induced by high a concentration of 5OCl (≥10 μM), but antagonized the relaxation induced by low concentrations of this propafenone derivate. Thus, 5OCl derivate has comparable potency and efficacy as propafenone. According to its interaction with lidocaine, 4-AP and nifedipine it seems that 5OCl partly shares the mechanism of action with propafenone. The mechanism of vasodilatation induced by high micromolar concentration of 5OCl is not defined and further investigations are necessary., Informacije o efektima propafenona na vaskularne glatke mišiće su oskudne. Propafenon blokira voltažno-zavisne Na+ kanale, Ca2+ kanale L-tipa, voltažno-senzitivne K+ (Kv) kanale i β-adrenergičke receptore u srcu. Uvođenje različitih hemijskih grupa u benzilni deo molekula propafenona utiče na promenu njegovih farmakoloških osobina. U ovoj studiji je ispitivan uticaj novog orto-hloro derivata (5OCl) propafenona na vaskularni tonus prekontrahovane aorte pacova. Orto hlorni derivat (5OCl) je izazvao endotel-nezavisnu relaksaciju aortnih prstenova. Da bi se ispitala uloga različitih jonskih kanala u ovoj relaksaciji, korišćeni su lidokain, (antagonist Na+ kanala), 4-aminopiridin (antagonist Kv kanala) i nifedipin (antagonist Ca2+ kanala L-tipa). Testirani antagonisti jonskih kanala nisu uticali na relaksaciju aorte pacova izazvanu visokom koncentracijom 5OCl (≥10 μM), ali su zato antagonizovali relaksaciju aorte koncentracijama 5OCl koje su bile manje od 10 μM. Prema tome, 5OCl derivat ima sličnu jačinu i efikasnost kao propafenon. Prema njegovoj interakciji sa lidokainom, 4-AP i nifedipinom može se reći da je mehanizam dejstva 5OCl sličan propafenonu. Mehanizam vazodilatacije 5OCl derivata u koncentracijama većim od 10 μM nije definisan i za to su potrebna dalja istraživanja.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta, Relaksacija aorte pacova indukovana novosintetisanim orto-hlornim derivatom propafenona",
volume = "63",
number = "4",
pages = "363-371",
doi = "10.2298/AVB1304363I"
}

Ivković, B., Gojković-Bukarica, L., Vladimirov, S., Novaković, R., Ćupić, V., Lešić, A., Bumbaširević, M.,& Šćepanović, R.. (2013). The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 63(4), 363-371.
https://doi.org/10.2298/AVB1304363I

Ivković B, Gojković-Bukarica L, Vladimirov S, Novaković R, Ćupić V, Lešić A, Bumbaširević M, Šćepanović R. The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta. in Acta veterinaria. 2013;63(4):363-371.
doi:10.2298/AVB1304363I .

Ivković, Branka, Gojković-Bukarica, Ljiljana, Vladimirov, S., Novaković, Radmila, Ćupić, Vitomir, Lešić, A., Bumbaširević, M., Šćepanović, Radisav, "The novel ortho-chloro derivate propafenone induced relaxation in isolated rat aorta" in Acta veterinaria, 63, no. 4 (2013):363-371,
https://doi.org/10.2298/AVB1304363I . .

TY  - JOUR
AU  - Ivković, Branka
AU  - Vladimirov, Sote
AU  - Novaković, Radmila
AU  - Ćupić, Vitomir
AU  - Heinle, Helmut
AU  - Gojković-Bukarica, Ljiljana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1740
AB  - Our aim was to define how different chemical properties of newly developed phenylpropiophenone derivates (PhPds) influenced their potency and efficacy to relax rat aorta. A contribution of ion channels in the PhPds and propafenone mechanism of vasodilatation was tested. PhPds were syntethysed by substitution in the benzyl moiety with -F, -CH3 or -CF3 groups on the ortho or para position. The vasodilatation by PhPds was examined on the rings of rat aorta precontracted with phenylephrine. In order to test involvement of voltage-gated Na+ and K+ channels and L-type Ca2+ channels in a mechanism of action of PhPds, we used their blockers: lidocaine, nifedipine and 4-aminopiridine, respectively. Aorta was more sensitive to 5-ortho-trifluoromethyl derivate than to propafenone and other PhPds. The 5-para-methyl derivate had lower potency and efficacy than propafenone and other PhPds. Lidocaine did not influenced relaxation induced by PhPds, but slightly inhibited the effect of propafenone. The 4-aminopiridine only inhibited relaxation induced by 5-para-methyl derivate. Nifedipine inhibited relaxation of the rat aorta induced by 5-ortho-trifluoromethyl derivate and by propafenone. Introduction of 5-ortho-trifluoromethyl and 5-para-methyl group in the benzyl moiety of propafenone molecule changed its potency, efficacy and mechanism of action in the rat aorta. The 4-aminopiridine- and nifedipine sensitive ion channels are involved in mechanism of action of 5-para-methyl and 5-ortho-trifluoromethyl derivate. The introduction of other tested groups in the benzyl moiety does not affect pharmacological properties of the PhPds in relation to propafenone.
PB  - Georg Thieme Verlag Kg, Stuttgart
T2  - Arzneimittelforschung - Drug Research
T1  - The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta
VL  - 62
IS  - 7
SP  - 345
EP  - 350
DO  - 10.1055/s-0032-1312617
ER  - 

@article{
author = "Ivković, Branka and Vladimirov, Sote and Novaković, Radmila and Ćupić, Vitomir and Heinle, Helmut and Gojković-Bukarica, Ljiljana",
year = "2012",
abstract = "Our aim was to define how different chemical properties of newly developed phenylpropiophenone derivates (PhPds) influenced their potency and efficacy to relax rat aorta. A contribution of ion channels in the PhPds and propafenone mechanism of vasodilatation was tested. PhPds were syntethysed by substitution in the benzyl moiety with -F, -CH3 or -CF3 groups on the ortho or para position. The vasodilatation by PhPds was examined on the rings of rat aorta precontracted with phenylephrine. In order to test involvement of voltage-gated Na+ and K+ channels and L-type Ca2+ channels in a mechanism of action of PhPds, we used their blockers: lidocaine, nifedipine and 4-aminopiridine, respectively. Aorta was more sensitive to 5-ortho-trifluoromethyl derivate than to propafenone and other PhPds. The 5-para-methyl derivate had lower potency and efficacy than propafenone and other PhPds. Lidocaine did not influenced relaxation induced by PhPds, but slightly inhibited the effect of propafenone. The 4-aminopiridine only inhibited relaxation induced by 5-para-methyl derivate. Nifedipine inhibited relaxation of the rat aorta induced by 5-ortho-trifluoromethyl derivate and by propafenone. Introduction of 5-ortho-trifluoromethyl and 5-para-methyl group in the benzyl moiety of propafenone molecule changed its potency, efficacy and mechanism of action in the rat aorta. The 4-aminopiridine- and nifedipine sensitive ion channels are involved in mechanism of action of 5-para-methyl and 5-ortho-trifluoromethyl derivate. The introduction of other tested groups in the benzyl moiety does not affect pharmacological properties of the PhPds in relation to propafenone.",
publisher = "Georg Thieme Verlag Kg, Stuttgart",
journal = "Arzneimittelforschung - Drug Research",
title = "The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta",
volume = "62",
number = "7",
pages = "345-350",
doi = "10.1055/s-0032-1312617"
}

Ivković, B., Vladimirov, S., Novaković, R., Ćupić, V., Heinle, H.,& Gojković-Bukarica, L.. (2012). The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta. in Arzneimittelforschung - Drug Research
Georg Thieme Verlag Kg, Stuttgart., 62(7), 345-350.
https://doi.org/10.1055/s-0032-1312617

Ivković B, Vladimirov S, Novaković R, Ćupić V, Heinle H, Gojković-Bukarica L. The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta. in Arzneimittelforschung - Drug Research. 2012;62(7):345-350.
doi:10.1055/s-0032-1312617 .

Ivković, Branka, Vladimirov, Sote, Novaković, Radmila, Ćupić, Vitomir, Heinle, Helmut, Gojković-Bukarica, Ljiljana, "The Novel Phenylpropiophenone Derivates Induced Relaxation of Isolated Rat Aorta" in Arzneimittelforschung - Drug Research, 62, no. 7 (2012):345-350,
https://doi.org/10.1055/s-0032-1312617 . .

TY  - CONF
AU  - Ivković, Branka
AU  - Vladimirov, Sote
AU  - Opacić, D.
AU  - Protić, D.
AU  - Novaković, Radmila
AU  - Cvejić, J.
AU  - Kanjuh, Vladimir
AU  - Gojković-Bukarica, Ljiljana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1550
PB  - Wiley-Blackwell, Malden
C3  - Basic & Clinical Pharmacology & Toxicology
T1  - Novel propafenone analogs have antiarrhythmic effect
VL  - 109
IS  - Supplement 1
SP  - 104
EP  - 105
DO  - 10.1111/j.1742-7843.2011.00722.x
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1550
ER  - 

@conference{
author = "Ivković, Branka and Vladimirov, Sote and Opacić, D. and Protić, D. and Novaković, Radmila and Cvejić, J. and Kanjuh, Vladimir and Gojković-Bukarica, Ljiljana",
year = "2011",
publisher = "Wiley-Blackwell, Malden",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Novel propafenone analogs have antiarrhythmic effect",
volume = "109",
number = "Supplement 1",
pages = "104-105",
doi = "10.1111/j.1742-7843.2011.00722.x",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1550"
}

Ivković, B., Vladimirov, S., Opacić, D., Protić, D., Novaković, R., Cvejić, J., Kanjuh, V.,& Gojković-Bukarica, L.. (2011). Novel propafenone analogs have antiarrhythmic effect. in Basic & Clinical Pharmacology & Toxicology
Wiley-Blackwell, Malden., 109(Supplement 1), 104-105.
https://doi.org/10.1111/j.1742-7843.2011.00722.x
https://hdl.handle.net/21.15107/rcub_farfar_1550

Ivković B, Vladimirov S, Opacić D, Protić D, Novaković R, Cvejić J, Kanjuh V, Gojković-Bukarica L. Novel propafenone analogs have antiarrhythmic effect. in Basic & Clinical Pharmacology & Toxicology. 2011;109(Supplement 1):104-105.
doi:10.1111/j.1742-7843.2011.00722.x
https://hdl.handle.net/21.15107/rcub_farfar_1550 .

Ivković, Branka, Vladimirov, Sote, Opacić, D., Protić, D., Novaković, Radmila, Cvejić, J., Kanjuh, Vladimir, Gojković-Bukarica, Ljiljana, "Novel propafenone analogs have antiarrhythmic effect" in Basic & Clinical Pharmacology & Toxicology, 109, no. Supplement 1 (2011):104-105,
https://doi.org/10.1111/j.1742-7843.2011.00722.x .,
https://hdl.handle.net/21.15107/rcub_farfar_1550 .

TY  - JOUR
AU  - Gojković-Bukarica, Ljiljana
AU  - Beleslin-Cokić, Bojana B.
AU  - Novaković, Aleksandra
AU  - Perić, Miodrag
AU  - Marković-Lipkovski, Jasmina
AU  - Cirović, Sanja Z.
AU  - Nezić, Dušan
AU  - Lesić, Aleksandar R.
AU  - Kanjuh, Vladimir
AU  - Heinle, Helmut
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1571
AB  - Because adrenergic contractions can contribute to the development of life-threatening spasm of coronary artery bypass graft, this study was performed to investigate the effect of adenosine 3-phosphate (ATP)-sensitive K(+) channel (K(ATP)) opener P1075 on contractions of isolated human saphenous vein (HSV) and human internal mammary artery (HIMA). Phasic contractions were evoked by electric field stimulation (20 Hz) and noradrenaline. The sustained contractions were evoked by phenylephrine. The presence of pore-forming Kir6.1 and Kir6.2 subunits of the K(ATP) channels in the HIMA and only Kir6.2 in the HSV was confirmed immunomorphologically. P1075 inhibited in the HSV only, the electrical field stimulation contractions more strongly than noradrenaline contractions. In addition, the phenylephrine contractions of HSV were more sensitive to P1075 in comparison to those of HIMA. Glibenclamide, a K(ATP) channel blocker antagonized the vasodilatation produced by P1075 in both grafts differently, because its effect was more prominent on the P1075-induced inhibition of contractions of HSV than of HIMA. We conclude that P1075 has a vasorelaxant effect and inhibited adrenergic contractions of the tested grafts. This effect is graft and vasoconstrictor selective and seems to be mediated by Kir6.1-and/or Kir6.2-containing K(ATP) channels. Thus, P1075 can be considered as a potential drug in the prevention of graft spasm.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of Cardiovascular Pharmacology
T1  - The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery
VL  - 57
IS  - 6
SP  - 648
EP  - 655
DO  - 10.1097/FJC.0b013e3182145850
ER  - 

@article{
author = "Gojković-Bukarica, Ljiljana and Beleslin-Cokić, Bojana B. and Novaković, Aleksandra and Perić, Miodrag and Marković-Lipkovski, Jasmina and Cirović, Sanja Z. and Nezić, Dušan and Lesić, Aleksandar R. and Kanjuh, Vladimir and Heinle, Helmut",
year = "2011",
abstract = "Because adrenergic contractions can contribute to the development of life-threatening spasm of coronary artery bypass graft, this study was performed to investigate the effect of adenosine 3-phosphate (ATP)-sensitive K(+) channel (K(ATP)) opener P1075 on contractions of isolated human saphenous vein (HSV) and human internal mammary artery (HIMA). Phasic contractions were evoked by electric field stimulation (20 Hz) and noradrenaline. The sustained contractions were evoked by phenylephrine. The presence of pore-forming Kir6.1 and Kir6.2 subunits of the K(ATP) channels in the HIMA and only Kir6.2 in the HSV was confirmed immunomorphologically. P1075 inhibited in the HSV only, the electrical field stimulation contractions more strongly than noradrenaline contractions. In addition, the phenylephrine contractions of HSV were more sensitive to P1075 in comparison to those of HIMA. Glibenclamide, a K(ATP) channel blocker antagonized the vasodilatation produced by P1075 in both grafts differently, because its effect was more prominent on the P1075-induced inhibition of contractions of HSV than of HIMA. We conclude that P1075 has a vasorelaxant effect and inhibited adrenergic contractions of the tested grafts. This effect is graft and vasoconstrictor selective and seems to be mediated by Kir6.1-and/or Kir6.2-containing K(ATP) channels. Thus, P1075 can be considered as a potential drug in the prevention of graft spasm.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of Cardiovascular Pharmacology",
title = "The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery",
volume = "57",
number = "6",
pages = "648-655",
doi = "10.1097/FJC.0b013e3182145850"
}

Gojković-Bukarica, L., Beleslin-Cokić, B. B., Novaković, A., Perić, M., Marković-Lipkovski, J., Cirović, S. Z., Nezić, D., Lesić, A. R., Kanjuh, V.,& Heinle, H.. (2011). The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery. in Journal of Cardiovascular Pharmacology
Lippincott Williams & Wilkins, Philadelphia., 57(6), 648-655.
https://doi.org/10.1097/FJC.0b013e3182145850

Gojković-Bukarica L, Beleslin-Cokić BB, Novaković A, Perić M, Marković-Lipkovski J, Cirović SZ, Nezić D, Lesić AR, Kanjuh V, Heinle H. The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery. in Journal of Cardiovascular Pharmacology. 2011;57(6):648-655.
doi:10.1097/FJC.0b013e3182145850 .

Gojković-Bukarica, Ljiljana, Beleslin-Cokić, Bojana B., Novaković, Aleksandra, Perić, Miodrag, Marković-Lipkovski, Jasmina, Cirović, Sanja Z., Nezić, Dušan, Lesić, Aleksandar R., Kanjuh, Vladimir, Heinle, Helmut, "The Effects of Potassium Channel Opener P1075 on the Human Saphenous Vein and Human Internal Mammary Artery" in Journal of Cardiovascular Pharmacology, 57, no. 6 (2011):648-655,
https://doi.org/10.1097/FJC.0b013e3182145850 . .

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Nezić, D.
AU  - Perić, M.
AU  - Kanjuh, Vladimir
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1411
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Cardioprotective effect of red wine
VL  - 11
IS  - 2
SP  - 27
EP  - 28
DO  - 10.1016/S1567-5688(10)70120-3
ER  - 

@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Nezić, D. and Perić, M. and Kanjuh, Vladimir",
year = "2010",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Cardioprotective effect of red wine",
volume = "11",
number = "2",
pages = "27-28",
doi = "10.1016/S1567-5688(10)70120-3"
}

Novaković, A., Gojković-Bukarica, L., Nezić, D., Perić, M.,& Kanjuh, V.. (2010). Cardioprotective effect of red wine. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 11(2), 27-28.
https://doi.org/10.1016/S1567-5688(10)70120-3

Novaković A, Gojković-Bukarica L, Nezić D, Perić M, Kanjuh V. Cardioprotective effect of red wine. in Atherosclerosis Supplements. 2010;11(2):27-28.
doi:10.1016/S1567-5688(10)70120-3 .

Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Nezić, D., Perić, M., Kanjuh, Vladimir, "Cardioprotective effect of red wine" in Atherosclerosis Supplements, 11, no. 2 (2010):27-28,
https://doi.org/10.1016/S1567-5688(10)70120-3 . .

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Perić, Miodrag
AU  - Nezić, Dušan
AU  - Kanjuh, Vladimir
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1397
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Circulation
T1  - The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein
VL  - 122
IS  - 2
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1397
ER  - 

@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Perić, Miodrag and Nezić, Dušan and Kanjuh, Vladimir",
year = "2010",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Circulation",
title = "The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein",
volume = "122",
number = "2",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1397"
}

Novaković, A., Gojković-Bukarica, L., Perić, M., Nezić, D.,& Kanjuh, V.. (2010). The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein. in Circulation
Lippincott Williams & Wilkins, Philadelphia., 122(2).
https://hdl.handle.net/21.15107/rcub_farfar_1397

Novaković A, Gojković-Bukarica L, Perić M, Nezić D, Kanjuh V. The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein. in Circulation. 2010;122(2).
https://hdl.handle.net/21.15107/rcub_farfar_1397 .

Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Perić, Miodrag, Nezić, Dušan, Kanjuh, Vladimir, "The Mechanism of Resveratrol-Induced Vasorelaxation in the Isolated Human Internal Mammary Artery and Human Saphenous Vein" in Circulation, 122, no. 2 (2010),
https://hdl.handle.net/21.15107/rcub_farfar_1397 .

TY  - CONF
AU  - Gojković-Bukarica, Ljiljana
AU  - Novaković, Aleksandra
AU  - Beleslin-Cokić, Bojana B.
AU  - Marković-Lipkovski, Jasmina
AU  - Perić, M.
AU  - Nezić, D.
AU  - Kanjuh, Vladimir
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1390
PB  - Wiley-Blackwell Publishing, Inc, Malden
C3  - European Journal of Clinical Investigation
T1  - The effect of P1075 on the isolated human saphenous vein
VL  - 40
SP  - 5
EP  - 5
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1390
ER  - 

@conference{
author = "Gojković-Bukarica, Ljiljana and Novaković, Aleksandra and Beleslin-Cokić, Bojana B. and Marković-Lipkovski, Jasmina and Perić, M. and Nezić, D. and Kanjuh, Vladimir",
year = "2010",
publisher = "Wiley-Blackwell Publishing, Inc, Malden",
journal = "European Journal of Clinical Investigation",
title = "The effect of P1075 on the isolated human saphenous vein",
volume = "40",
pages = "5-5",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1390"
}

Gojković-Bukarica, L., Novaković, A., Beleslin-Cokić, B. B., Marković-Lipkovski, J., Perić, M., Nezić, D.,& Kanjuh, V.. (2010). The effect of P1075 on the isolated human saphenous vein. in European Journal of Clinical Investigation
Wiley-Blackwell Publishing, Inc, Malden., 40, 5-5.
https://hdl.handle.net/21.15107/rcub_farfar_1390

Gojković-Bukarica L, Novaković A, Beleslin-Cokić BB, Marković-Lipkovski J, Perić M, Nezić D, Kanjuh V. The effect of P1075 on the isolated human saphenous vein. in European Journal of Clinical Investigation. 2010;40:5-5.
https://hdl.handle.net/21.15107/rcub_farfar_1390 .

Gojković-Bukarica, Ljiljana, Novaković, Aleksandra, Beleslin-Cokić, Bojana B., Marković-Lipkovski, Jasmina, Perić, M., Nezić, D., Kanjuh, Vladimir, "The effect of P1075 on the isolated human saphenous vein" in European Journal of Clinical Investigation, 40 (2010):5-5,
https://hdl.handle.net/21.15107/rcub_farfar_1390 .

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Kanjuh, Vladimir
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1046
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Cardioprotective effect of resveratrol
VL  - 9
IS  - 1
SP  - 12
EP  - 12
DO  - 10.1016/S1567-5688(08)70043-6
ER  - 

@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Kanjuh, Vladimir",
year = "2008",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Cardioprotective effect of resveratrol",
volume = "9",
number = "1",
pages = "12-12",
doi = "10.1016/S1567-5688(08)70043-6"
}

Novaković, A., Gojković-Bukarica, L.,& Kanjuh, V.. (2008). Cardioprotective effect of resveratrol. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 9(1), 12-12.
https://doi.org/10.1016/S1567-5688(08)70043-6

Novaković A, Gojković-Bukarica L, Kanjuh V. Cardioprotective effect of resveratrol. in Atherosclerosis Supplements. 2008;9(1):12-12.
doi:10.1016/S1567-5688(08)70043-6 .

Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Kanjuh, Vladimir, "Cardioprotective effect of resveratrol" in Atherosclerosis Supplements, 9, no. 1 (2008):12-12,
https://doi.org/10.1016/S1567-5688(08)70043-6 . .

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Nezić, D.
AU  - Perić, M.
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1100
PB  - Lippincott Williams & Wilkins, Philadelphia
C3  - Circulation
T1  - Cardioprotective effect of red wine
VL  - 118
IS  - 12
SP  - e171
EP  - e171
DO  - 10.1161/CIRCULATIONAHA.108.189874
ER  - 

@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Nezić, D. and Perić, M.",
year = "2008",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Circulation",
title = "Cardioprotective effect of red wine",
volume = "118",
number = "12",
pages = "e171-e171",
doi = "10.1161/CIRCULATIONAHA.108.189874"
}

Novaković, A., Gojković-Bukarica, L., Nezić, D.,& Perić, M.. (2008). Cardioprotective effect of red wine. in Circulation
Lippincott Williams & Wilkins, Philadelphia., 118(12), e171-e171.
https://doi.org/10.1161/CIRCULATIONAHA.108.189874

Novaković A, Gojković-Bukarica L, Nezić D, Perić M. Cardioprotective effect of red wine. in Circulation. 2008;118(12):e171-e171.
doi:10.1161/CIRCULATIONAHA.108.189874 .

Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Nezić, D., Perić, M., "Cardioprotective effect of red wine" in Circulation, 118, no. 12 (2008):e171-e171,
https://doi.org/10.1161/CIRCULATIONAHA.108.189874 . .

TY  - JOUR
AU  - Gojković-Bukarica, Ljiljana
AU  - Novaković, Aleksandra
AU  - Kanjuh, Vladimir
AU  - Bumbasirević, Marko
AU  - Lesić, Aleksandar
AU  - Heinle, Helmut
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1041
AB  - Recently it has been suggested that resveratrol relaxes different isolated arteries. The present study addressed the question whether different ion channels are involved in the endothelium-independent mechanism of vasodilatation induced by resveratrol. For that purpose, we tested the action of resveratrol on the rat mesenteric artery without endothelium. Resveratrol induced con centration-dependent relaxation of rat mesenteric artery. Among the K+-channel blockers, 4-amynopiridine (4-AP) moderately antagonized the resveratrol-induced relaxation, while glibendamide, tetraethylammonium chloride, charybdotoxin, margatoxin, and barium chloride did not inhibit resveratrol-induced vasorelaxation. In rings, precontracted with 100 mM K+, the relaxant responses to resveratrol were highly significantly shifted to the right compared to those obtained in rings precontracted with phenylephrine, but resveratrol-induced maximal relaxation was only slightly affected. In order to minimize the influence of K+ channels and voltage-gated Ca2+ channels (VGCCs) in vascular smooth muscle, the third contraction was made by 100 in M K- in the presence of nifedipine. The relaxant response to resveratrol was abolished. Thus, the mechanism of vasorelaxation induced by resveratrol probably involves activation of 4-AP-sensitive K+ channels. Its ability to completely relax the mesenteric artery precontracted with K+-rich solution suggests that K channel-independent mechanism(s) are involved in its vasorelaxant effect. It seems that interaction with VGCCs plays a part in this K+ channel-independent effect of resveratrol.
PB  - Japanese Pharmacological Soc, Kyoto
T2  - Journal of Pharmacological Sciences
T1  - A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol
VL  - 108
IS  - 1
SP  - 124
EP  - 130
DO  - 10.1254/jphs.08128FP
ER  - 

@article{
author = "Gojković-Bukarica, Ljiljana and Novaković, Aleksandra and Kanjuh, Vladimir and Bumbasirević, Marko and Lesić, Aleksandar and Heinle, Helmut",
year = "2008",
abstract = "Recently it has been suggested that resveratrol relaxes different isolated arteries. The present study addressed the question whether different ion channels are involved in the endothelium-independent mechanism of vasodilatation induced by resveratrol. For that purpose, we tested the action of resveratrol on the rat mesenteric artery without endothelium. Resveratrol induced con centration-dependent relaxation of rat mesenteric artery. Among the K+-channel blockers, 4-amynopiridine (4-AP) moderately antagonized the resveratrol-induced relaxation, while glibendamide, tetraethylammonium chloride, charybdotoxin, margatoxin, and barium chloride did not inhibit resveratrol-induced vasorelaxation. In rings, precontracted with 100 mM K+, the relaxant responses to resveratrol were highly significantly shifted to the right compared to those obtained in rings precontracted with phenylephrine, but resveratrol-induced maximal relaxation was only slightly affected. In order to minimize the influence of K+ channels and voltage-gated Ca2+ channels (VGCCs) in vascular smooth muscle, the third contraction was made by 100 in M K- in the presence of nifedipine. The relaxant response to resveratrol was abolished. Thus, the mechanism of vasorelaxation induced by resveratrol probably involves activation of 4-AP-sensitive K+ channels. Its ability to completely relax the mesenteric artery precontracted with K+-rich solution suggests that K channel-independent mechanism(s) are involved in its vasorelaxant effect. It seems that interaction with VGCCs plays a part in this K+ channel-independent effect of resveratrol.",
publisher = "Japanese Pharmacological Soc, Kyoto",
journal = "Journal of Pharmacological Sciences",
title = "A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol",
volume = "108",
number = "1",
pages = "124-130",
doi = "10.1254/jphs.08128FP"
}

Gojković-Bukarica, L., Novaković, A., Kanjuh, V., Bumbasirević, M., Lesić, A.,& Heinle, H.. (2008). A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol. in Journal of Pharmacological Sciences
Japanese Pharmacological Soc, Kyoto., 108(1), 124-130.
https://doi.org/10.1254/jphs.08128FP

Gojković-Bukarica L, Novaković A, Kanjuh V, Bumbasirević M, Lesić A, Heinle H. A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol. in Journal of Pharmacological Sciences. 2008;108(1):124-130.
doi:10.1254/jphs.08128FP .

Gojković-Bukarica, Ljiljana, Novaković, Aleksandra, Kanjuh, Vladimir, Bumbasirević, Marko, Lesić, Aleksandar, Heinle, Helmut, "A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol" in Journal of Pharmacological Sciences, 108, no. 1 (2008):124-130,
https://doi.org/10.1254/jphs.08128FP . .

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Perić, M.
AU  - Nezić, D.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/745
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Human internal thoracic artery relaxed by resveratrol
T1  - Relaksacija humane unutrašnje torakalne arterije prouzrokovana rezveratrolom
VL  - 56
IS  - 4
SP  - 390
EP  - 391
UR  - https://hdl.handle.net/21.15107/rcub_farfar_745
ER  - 

@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Perić, M. and Nezić, D.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Human internal thoracic artery relaxed by resveratrol, Relaksacija humane unutrašnje torakalne arterije prouzrokovana rezveratrolom",
volume = "56",
number = "4",
pages = "390-391",
url = "https://hdl.handle.net/21.15107/rcub_farfar_745"
}

Novaković, A., Gojković-Bukarica, L., Perić, M.,& Nezić, D.. (2006). Human internal thoracic artery relaxed by resveratrol. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 390-391.
https://hdl.handle.net/21.15107/rcub_farfar_745

Novaković A, Gojković-Bukarica L, Perić M, Nezić D. Human internal thoracic artery relaxed by resveratrol. in Arhiv za farmaciju. 2006;56(4):390-391.
https://hdl.handle.net/21.15107/rcub_farfar_745 .

Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Perić, M., Nezić, D., "Human internal thoracic artery relaxed by resveratrol" in Arhiv za farmaciju, 56, no. 4 (2006):390-391,
https://hdl.handle.net/21.15107/rcub_farfar_745 .

TY  - JOUR
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Perić, M.
AU  - Nežić, D.
AU  - Đukanović, B.
AU  - Lešić, A.
AU  - Bumbaširević, M.
AU  - Marković-Lipkovski, Jasmina
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/871
AB  - Resveratrol, a polyphenol present in wine, has been thought to be responsible for cardiovascular benefits associated with moderate wine consumption. It is also present in the plant Polygonum Cuspidatum. The mechanism of cardiovascular benefits probably includes vasorelaxation, antioxidant and anti-platelet effects of resveratrol. The mechanisms by which resveratrol causes vasodilatation are uncertain. The aim of this study was to investigate the mechanism(s) of resveratrol induced vasorelaxation in human internal mammary artery (HIMA) with endothelium. HIMA rings were precontracted by phenylephrine. Resveratrol induced relaxation of the HIMA rings with endothelium. LNAME, an inhibitor of NO synthase, and methylene blue, an inhibitor of guanylate cyclase, abolished relaxation of HIMA induced by resveratrol. Highly selective blocker of ATP-sensitive K channels, glibenclamide as well as a nonselective blocker of big Ca-sensitive K+ channels, charybdotoxin did not block resveratrol-induced relaxation of HIMA. 4-Aminopyridine and margatoxin, blockers of voltage-gated K+ (KV) channels, abolished endothelium-dependent relaxation of HIMA, induced by resveratrol. In conclusion, we have shown that resveratrol induces relaxation of HIMA with endothelium. It seems that NO and smooth muscle KV channels are included in this relaxation.
AB  - Smatra se da rezveratrol kao jedna polifenolna komponenta prisutna u značajnim količinama u crnom vinu, smanjuje rizik od razvoja ateroskleroze i koronarne bolesti. U mehanizam kardioprotektivnog delovanja verovatno su uključ eni antioksidativno, antitrombocitno i vazodilatatorno delovanje rezveratrola. Mehanizam vazodilatacije još uvek nije poznat, pa je cilj ovog rada bio da se ispitaju efekti i mehanizam vazorelaksantnog delovanja rezveratrola na humanoj unutraš njoj torakalnoj arteriji sa endotelom. Unutrašnja torakalna arterija je prekontrahovana fenilefrinom. Rezveratrol je koncentracijski-zavisno relaksirao unutrašnju torakalnu arteriju čoveka. L-NAME, inhibitor NO sintaze, i metilensko plavo, inhibitor solubilne gvanilat ciklaze, su antagonizovali relaksaciju unutrašnje torakalne arterije sa intaktnim endotelom, prouzrokovanu rezveratrolom. Visoko selektivni blokator ATP-senzitivnih K+ kanala, glibenklamid, kao i neselektivni blokator velikih Ca-senzitivnih K+ kanala, karibdotoksin nisu antagonizovali rezveratrolom indukovanu relaksaciju unutrašnje torakalne arterije. 4-Aminopiridin i margatoksin, blokatori voltažnih K+ kanala su antagonizovali relaksaciju prouzrokovanu rezveratrolom. Na osnovu ovih činjenica se može zaključiti da je endotel-zavisna relaksacija unutrašnje torakalne arterije čoveka, prouzrokovana rezveratrolom, verovatno posredovana NO. Izgleda, da su 4-aminopiriin- i margatoksin-senzitivni K-kanali smešteni u membrani vaskularnih glatko-mišićnih ćelija humane unutrašnje torakalne arterije, uključeni u mehanizam endotel-zavisne relaksacije prouzrokovane rezveratrolom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Endothelium-dependent relaxation of internal mammary artery produced by resveratrol
T1  - Endotel-zavisna relaksacija unutrašnje torakalne arterije prouzrokovana rezveratrolom
VL  - 56
IS  - 2-3
SP  - 203
EP  - 213
DO  - 10.2298/AVB0603203N
ER  - 

@article{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Perić, M. and Nežić, D. and Đukanović, B. and Lešić, A. and Bumbaširević, M. and Marković-Lipkovski, Jasmina",
year = "2006",
abstract = "Resveratrol, a polyphenol present in wine, has been thought to be responsible for cardiovascular benefits associated with moderate wine consumption. It is also present in the plant Polygonum Cuspidatum. The mechanism of cardiovascular benefits probably includes vasorelaxation, antioxidant and anti-platelet effects of resveratrol. The mechanisms by which resveratrol causes vasodilatation are uncertain. The aim of this study was to investigate the mechanism(s) of resveratrol induced vasorelaxation in human internal mammary artery (HIMA) with endothelium. HIMA rings were precontracted by phenylephrine. Resveratrol induced relaxation of the HIMA rings with endothelium. LNAME, an inhibitor of NO synthase, and methylene blue, an inhibitor of guanylate cyclase, abolished relaxation of HIMA induced by resveratrol. Highly selective blocker of ATP-sensitive K channels, glibenclamide as well as a nonselective blocker of big Ca-sensitive K+ channels, charybdotoxin did not block resveratrol-induced relaxation of HIMA. 4-Aminopyridine and margatoxin, blockers of voltage-gated K+ (KV) channels, abolished endothelium-dependent relaxation of HIMA, induced by resveratrol. In conclusion, we have shown that resveratrol induces relaxation of HIMA with endothelium. It seems that NO and smooth muscle KV channels are included in this relaxation., Smatra se da rezveratrol kao jedna polifenolna komponenta prisutna u značajnim količinama u crnom vinu, smanjuje rizik od razvoja ateroskleroze i koronarne bolesti. U mehanizam kardioprotektivnog delovanja verovatno su uključ eni antioksidativno, antitrombocitno i vazodilatatorno delovanje rezveratrola. Mehanizam vazodilatacije još uvek nije poznat, pa je cilj ovog rada bio da se ispitaju efekti i mehanizam vazorelaksantnog delovanja rezveratrola na humanoj unutraš njoj torakalnoj arteriji sa endotelom. Unutrašnja torakalna arterija je prekontrahovana fenilefrinom. Rezveratrol je koncentracijski-zavisno relaksirao unutrašnju torakalnu arteriju čoveka. L-NAME, inhibitor NO sintaze, i metilensko plavo, inhibitor solubilne gvanilat ciklaze, su antagonizovali relaksaciju unutrašnje torakalne arterije sa intaktnim endotelom, prouzrokovanu rezveratrolom. Visoko selektivni blokator ATP-senzitivnih K+ kanala, glibenklamid, kao i neselektivni blokator velikih Ca-senzitivnih K+ kanala, karibdotoksin nisu antagonizovali rezveratrolom indukovanu relaksaciju unutrašnje torakalne arterije. 4-Aminopiridin i margatoksin, blokatori voltažnih K+ kanala su antagonizovali relaksaciju prouzrokovanu rezveratrolom. Na osnovu ovih činjenica se može zaključiti da je endotel-zavisna relaksacija unutrašnje torakalne arterije čoveka, prouzrokovana rezveratrolom, verovatno posredovana NO. Izgleda, da su 4-aminopiriin- i margatoksin-senzitivni K-kanali smešteni u membrani vaskularnih glatko-mišićnih ćelija humane unutrašnje torakalne arterije, uključeni u mehanizam endotel-zavisne relaksacije prouzrokovane rezveratrolom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Endothelium-dependent relaxation of internal mammary artery produced by resveratrol, Endotel-zavisna relaksacija unutrašnje torakalne arterije prouzrokovana rezveratrolom",
volume = "56",
number = "2-3",
pages = "203-213",
doi = "10.2298/AVB0603203N"
}

Novaković, A., Gojković-Bukarica, L., Perić, M., Nežić, D., Đukanović, B., Lešić, A., Bumbaširević, M.,& Marković-Lipkovski, J.. (2006). Endothelium-dependent relaxation of internal mammary artery produced by resveratrol. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 56(2-3), 203-213.
https://doi.org/10.2298/AVB0603203N

Novaković A, Gojković-Bukarica L, Perić M, Nežić D, Đukanović B, Lešić A, Bumbaširević M, Marković-Lipkovski J. Endothelium-dependent relaxation of internal mammary artery produced by resveratrol. in Acta veterinaria. 2006;56(2-3):203-213.
doi:10.2298/AVB0603203N .

Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Perić, M., Nežić, D., Đukanović, B., Lešić, A., Bumbaširević, M., Marković-Lipkovski, Jasmina, "Endothelium-dependent relaxation of internal mammary artery produced by resveratrol" in Acta veterinaria, 56, no. 2-3 (2006):203-213,
https://doi.org/10.2298/AVB0603203N . .

TY  - JOUR
AU  - Nežić, D.
AU  - Milojević, Predrag
AU  - Ćirković, M.
AU  - Knežević, A.
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Jović, M.
AU  - Đukanović, B.
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/630
AB  - Coronary artery bypass grafting (CABG) is the standard surgical procedure for the treatment of advanced coronary artery disease. CABG surgery has been demonstrated to improve symptoms and, in specific subgroups of patients, to prolong life. Despite its success, the long-term outcome of coronary bypass surgery is strongly influenced by the fate of the vascular conduits used. Previous long-term studies have shown unsatisfactory patency of saphenous vein grafts used for myocardial revascularisation, compared with internal mammary artery grafts. Recently, the use of radial artery for CABG has enjoyed a revival, on the basis of the belief that it will help improving long-term results of coronary operations. The recent reports of encouraging mid-term and long-term patency rates of the radial artery, supports its continued use as a bypass conduit. In this paper, we review the current knowledge about the radial artery as a bypass graft, with special emphasis on the clinical results.
AB  - Hirurška revaskularizacija miokarda je standardna procedura u tretmanu uznapredovale koronarne bolesti. Dokazano je da koronarna hirurgija uklanja simptome i produžava život određenih kategorija koronarnih bolesnika. Dugotrajni rezultati hirurške revaskularizacije miokarda u velikoj meri ovise o promenama koje se vremenom javljaju na upotrebljenom graftu. Studije dugoročnog praćenja operisanih bolesnika potvrdile su izuzetan kvalitet i prednost grafta unutarnje torakalne arterije u odnosu na venski graft. U skorije vreme obnovljeno je interesovanje za graft radijalne arterije, sa uverenjem da će njegova primena omogućiti bolje dugoročne rezultate. U poslednje vreme prikazani su radovi koji potvrđuju izuzetnu kratkoročnu i dugoročnu prohodnost grafta radijalne arterije i govore u prilog intenzivnije primene toga grafta u hirurškoj revaskularizaciji miokarda. Na prikaz je pregled sadanjih saznanja o radijalnoj arteriji kao graftu u kardiohirurgiji, sa posebnim osvrtom na kliničke rezultate.
PB  - Udruženje hirurga Jugoslavije, Beograd
T2  - Acta chirurgica iugoslavica
T1  - The radial artery for coronary artery bypass grafting
VL  - 52
IS  - 3
SP  - 11
EP  - 19
DO  - 10.2298/ACI0503011N
ER  - 

@article{
author = "Nežić, D. and Milojević, Predrag and Ćirković, M. and Knežević, A. and Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Jović, M. and Đukanović, B.",
year = "2005",
abstract = "Coronary artery bypass grafting (CABG) is the standard surgical procedure for the treatment of advanced coronary artery disease. CABG surgery has been demonstrated to improve symptoms and, in specific subgroups of patients, to prolong life. Despite its success, the long-term outcome of coronary bypass surgery is strongly influenced by the fate of the vascular conduits used. Previous long-term studies have shown unsatisfactory patency of saphenous vein grafts used for myocardial revascularisation, compared with internal mammary artery grafts. Recently, the use of radial artery for CABG has enjoyed a revival, on the basis of the belief that it will help improving long-term results of coronary operations. The recent reports of encouraging mid-term and long-term patency rates of the radial artery, supports its continued use as a bypass conduit. In this paper, we review the current knowledge about the radial artery as a bypass graft, with special emphasis on the clinical results., Hirurška revaskularizacija miokarda je standardna procedura u tretmanu uznapredovale koronarne bolesti. Dokazano je da koronarna hirurgija uklanja simptome i produžava život određenih kategorija koronarnih bolesnika. Dugotrajni rezultati hirurške revaskularizacije miokarda u velikoj meri ovise o promenama koje se vremenom javljaju na upotrebljenom graftu. Studije dugoročnog praćenja operisanih bolesnika potvrdile su izuzetan kvalitet i prednost grafta unutarnje torakalne arterije u odnosu na venski graft. U skorije vreme obnovljeno je interesovanje za graft radijalne arterije, sa uverenjem da će njegova primena omogućiti bolje dugoročne rezultate. U poslednje vreme prikazani su radovi koji potvrđuju izuzetnu kratkoročnu i dugoročnu prohodnost grafta radijalne arterije i govore u prilog intenzivnije primene toga grafta u hirurškoj revaskularizaciji miokarda. Na prikaz je pregled sadanjih saznanja o radijalnoj arteriji kao graftu u kardiohirurgiji, sa posebnim osvrtom na kliničke rezultate.",
publisher = "Udruženje hirurga Jugoslavije, Beograd",
journal = "Acta chirurgica iugoslavica",
title = "The radial artery for coronary artery bypass grafting",
volume = "52",
number = "3",
pages = "11-19",
doi = "10.2298/ACI0503011N"
}

Nežić, D., Milojević, P., Ćirković, M., Knežević, A., Novaković, A., Gojković-Bukarica, L., Jović, M.,& Đukanović, B.. (2005). The radial artery for coronary artery bypass grafting. in Acta chirurgica iugoslavica
Udruženje hirurga Jugoslavije, Beograd., 52(3), 11-19.
https://doi.org/10.2298/ACI0503011N

Nežić D, Milojević P, Ćirković M, Knežević A, Novaković A, Gojković-Bukarica L, Jović M, Đukanović B. The radial artery for coronary artery bypass grafting. in Acta chirurgica iugoslavica. 2005;52(3):11-19.
doi:10.2298/ACI0503011N .

Nežić, D., Milojević, Predrag, Ćirković, M., Knežević, A., Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Jović, M., Đukanović, B., "The radial artery for coronary artery bypass grafting" in Acta chirurgica iugoslavica, 52, no. 3 (2005):11-19,
https://doi.org/10.2298/ACI0503011N . .

TY  - CONF
AU  - Novaković, Aleksandra
AU  - Gojković-Bukarica, Ljiljana
AU  - Kažić, Tomislav M.
AU  - Sajić, Zoran
AU  - Đukanović, Boško P.
AU  - Perić, M.
AU  - Kanjuh, Vladimir
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/405
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens
T1  - Reaktivnost arterijskih i venskih bajpas graftova na potencijalne farmakološke spazmogene
VL  - 52
IS  - 4
SP  - 630
EP  - 631
UR  - https://hdl.handle.net/21.15107/rcub_farfar_405
ER  - 

@conference{
author = "Novaković, Aleksandra and Gojković-Bukarica, Ljiljana and Kažić, Tomislav M. and Sajić, Zoran and Đukanović, Boško P. and Perić, M. and Kanjuh, Vladimir",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens, Reaktivnost arterijskih i venskih bajpas graftova na potencijalne farmakološke spazmogene",
volume = "52",
number = "4",
pages = "630-631",
url = "https://hdl.handle.net/21.15107/rcub_farfar_405"
}

Novaković, A., Gojković-Bukarica, L., Kažić, T. M., Sajić, Z., Đukanović, B. P., Perić, M.,& Kanjuh, V.. (2002). Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 630-631.
https://hdl.handle.net/21.15107/rcub_farfar_405

Novaković A, Gojković-Bukarica L, Kažić TM, Sajić Z, Đukanović BP, Perić M, Kanjuh V. Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens. in Arhiv za farmaciju. 2002;52(4):630-631.
https://hdl.handle.net/21.15107/rcub_farfar_405 .

Novaković, Aleksandra, Gojković-Bukarica, Ljiljana, Kažić, Tomislav M., Sajić, Zoran, Đukanović, Boško P., Perić, M., Kanjuh, Vladimir, "Reactivity of arterial and vein bypass grafts to potential pharmalogical spasmogens" in Arhiv za farmaciju, 52, no. 4 (2002):630-631,
https://hdl.handle.net/21.15107/rcub_farfar_405 .

TY  - JOUR
AU  - Gojković-Bukarica, Ljiljana
AU  - Kazić, T
AU  - Beleslin Cokić, B
AU  - Novaković, Aleksandra
AU  - Perić, M
AU  - Sajić, Zoran
AU  - Bojić, M
AU  - Đukanović, B
AU  - Kanjuh, Vladimir
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/275
AB  - To investigate whether the antivasoconstrictor effect of P1075, a potassium channel openers, could be partly due to modulation of neurotransmitter release from adrenergic nerve endings we analysed the presynaptic and postsynaptic effects of P1075 on the isolated human saphenous vein (HSV). The HSV rings were contracted by electrical field stimulation (EFS) or by exogenous noradrenaline (10 μM; NA). The repetitive transmural EFS was carried out at 20 Hz with square wave pulses of 0.3 ms duration and supramaximal voltage. The contraction of the HSV in response to transmural EFS recorded in our experiments are neurogenic in nature, as this effect was abolished by tetrodotoxin (1 μM). We have also found that phentolamine (1 μM) inhibited almost completly (90 ″ 2%) the HSV contractions to EFS suggesting that this response was mediated by NA release from perivascular sympathetic nerve endings activating postjuncional α adrenoceptors. P1075 (0.01-10 μM) induced a concentration-dependent inhibition of both neurogenic contractions, and contractions evoked by exogenous NA of the HSV with pEC 50 values of of 6.48 ″ 0.05 and 6.36″ 0.08. The difference between the pEC 50 values (r) was not statistically significant (P > 0.05). These results suggest that the antivasoconstrictor effect of P1075 on the HSV might be postsynaptic, and associated with opening of the smooth muscle potassium channels.
PB  - BMJ Publishing Group
T2  - Heart
T1  - The antivasoconstrictor effect of P1075 on the isolated human saphenous vein
VL  - 83
IS  - SUPPL. 2
UR  - https://hdl.handle.net/21.15107/rcub_farfar_275
ER  - 

@article{
author = "Gojković-Bukarica, Ljiljana and Kazić, T and Beleslin Cokić, B and Novaković, Aleksandra and Perić, M and Sajić, Zoran and Bojić, M and Đukanović, B and Kanjuh, Vladimir",
year = "2000",
abstract = "To investigate whether the antivasoconstrictor effect of P1075, a potassium channel openers, could be partly due to modulation of neurotransmitter release from adrenergic nerve endings we analysed the presynaptic and postsynaptic effects of P1075 on the isolated human saphenous vein (HSV). The HSV rings were contracted by electrical field stimulation (EFS) or by exogenous noradrenaline (10 μM; NA). The repetitive transmural EFS was carried out at 20 Hz with square wave pulses of 0.3 ms duration and supramaximal voltage. The contraction of the HSV in response to transmural EFS recorded in our experiments are neurogenic in nature, as this effect was abolished by tetrodotoxin (1 μM). We have also found that phentolamine (1 μM) inhibited almost completly (90 ″ 2%) the HSV contractions to EFS suggesting that this response was mediated by NA release from perivascular sympathetic nerve endings activating postjuncional α adrenoceptors. P1075 (0.01-10 μM) induced a concentration-dependent inhibition of both neurogenic contractions, and contractions evoked by exogenous NA of the HSV with pEC 50 values of of 6.48 ″ 0.05 and 6.36″ 0.08. The difference between the pEC 50 values (r) was not statistically significant (P > 0.05). These results suggest that the antivasoconstrictor effect of P1075 on the HSV might be postsynaptic, and associated with opening of the smooth muscle potassium channels.",
publisher = "BMJ Publishing Group",
journal = "Heart",
title = "The antivasoconstrictor effect of P1075 on the isolated human saphenous vein",
volume = "83",
number = "SUPPL. 2",
url = "https://hdl.handle.net/21.15107/rcub_farfar_275"
}

Gojković-Bukarica, L., Kazić, T., Beleslin Cokić, B., Novaković, A., Perić, M., Sajić, Z., Bojić, M., Đukanović, B.,& Kanjuh, V.. (2000). The antivasoconstrictor effect of P1075 on the isolated human saphenous vein. in Heart
BMJ Publishing Group., 83(SUPPL. 2).
https://hdl.handle.net/21.15107/rcub_farfar_275

Gojković-Bukarica L, Kazić T, Beleslin Cokić B, Novaković A, Perić M, Sajić Z, Bojić M, Đukanović B, Kanjuh V. The antivasoconstrictor effect of P1075 on the isolated human saphenous vein. in Heart. 2000;83(SUPPL. 2).
https://hdl.handle.net/21.15107/rcub_farfar_275 .

Gojković-Bukarica, Ljiljana, Kazić, T, Beleslin Cokić, B, Novaković, Aleksandra, Perić, M, Sajić, Zoran, Bojić, M, Đukanović, B, Kanjuh, Vladimir, "The antivasoconstrictor effect of P1075 on the isolated human saphenous vein" in Heart, 83, no. SUPPL. 2 (2000),
https://hdl.handle.net/21.15107/rcub_farfar_275 .