Jovanović, Aleksandar

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orcid::0000-0001-9679-8384
  • Jovanović, Aleksandar (9)
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Author's Bibliography

Urinary tract health in the male population in the Republic of Serbia—part I

Jovanović, Aleksandar; Dimić, Nemanja; Catić Ðorđević, Aleksandra; Tadić, Ivana; Milošević-Georgiev, Andrijana

(Springer, 2023)

TY  - CONF
AU  - Jovanović, Aleksandar
AU  - Dimić, Nemanja
AU  - Catić Ðorđević, Aleksandra
AU  - Tadić, Ivana
AU  - Milošević-Georgiev, Andrijana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5492
AB  - Background Lower urinary tract symptoms (LUTS) significantly affect the quality of life of men, with a prevalence of 60% to 84%, which increases with age. However, a relatively small percentage of affected men seek advice or treatment for their symptoms. ...
PB  - Springer
C3  - International Journal of Clinical Pharmacy
T1  - Urinary tract health in the male population in the Republic of Serbia—part I
VL  - 45
IS  - 2
SP  - 537
EP  - 537
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5492
ER  - 
@conference{
author = "Jovanović, Aleksandar and Dimić, Nemanja and Catić Ðorđević, Aleksandra and Tadić, Ivana and Milošević-Georgiev, Andrijana",
year = "2023",
abstract = "Background Lower urinary tract symptoms (LUTS) significantly affect the quality of life of men, with a prevalence of 60% to 84%, which increases with age. However, a relatively small percentage of affected men seek advice or treatment for their symptoms. ...",
publisher = "Springer",
journal = "International Journal of Clinical Pharmacy",
title = "Urinary tract health in the male population in the Republic of Serbia—part I",
volume = "45",
number = "2",
pages = "537-537",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5492"
}
Jovanović, A., Dimić, N., Catić Ðorđević, A., Tadić, I.,& Milošević-Georgiev, A.. (2023). Urinary tract health in the male population in the Republic of Serbia—part I. in International Journal of Clinical Pharmacy
Springer., 45(2), 537-537.
https://hdl.handle.net/21.15107/rcub_farfar_5492
Jovanović A, Dimić N, Catić Ðorđević A, Tadić I, Milošević-Georgiev A. Urinary tract health in the male population in the Republic of Serbia—part I. in International Journal of Clinical Pharmacy. 2023;45(2):537-537.
https://hdl.handle.net/21.15107/rcub_farfar_5492 .
Jovanović, Aleksandar, Dimić, Nemanja, Catić Ðorđević, Aleksandra, Tadić, Ivana, Milošević-Georgiev, Andrijana, "Urinary tract health in the male population in the Republic of Serbia—part I" in International Journal of Clinical Pharmacy, 45, no. 2 (2023):537-537,
https://hdl.handle.net/21.15107/rcub_farfar_5492 .

Dijabetes u Srbiji: trendovi u potrošnji antidijabetika od 2012. do 2021. godine

Jovanović, Aleksandar; Kundalić, Ana; Miladinović, Bojana; Džodić, Predrag; Catić-Đorđević, Aleksandra; Krajnović, Dušanka; Tadić, Ivana

(Savez farmaceutskih udruženja Srbije, 2023)

TY  - CONF
AU  - Jovanović, Aleksandar
AU  - Kundalić, Ana
AU  - Miladinović, Bojana
AU  - Džodić, Predrag
AU  - Catić-Đorđević, Aleksandra
AU  - Krajnović, Dušanka
AU  - Tadić, Ivana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5352
AB  - Kao jedan od najvećih javnozdravstvenih izazova diabetes mellitus predstavlja razlog
konstantnog unapređenja farmakoterapije (1). Savremena terapija diabetes mellitus-a može
promeniti tok bolesti, prevenirati komplikacije i doprineti uštedi u zdravstvu (2). Cilj rada bio je da
se analizira potrošnja antidijabetika u Srbiji, u periodu od 2012. do 2021. godine i usklađenost sa
preporukama Nacionalnog vodiča. Podaci o potrošnji antidijabetika prikupljeni su iz publikacija
Agencije za lekove i medicinska sredstva Srbije. Za svaki internacionalni nezaštićen naziv (INN),
praćena je potrošnja izražena u standardizovanoj jedinici - definisanoj dnevnoj dozi na 1000
stanovnika u danu (DDD/1000 stanovnika/dan). Najveća potrošnja antidijabetika tokom ispitivanog
perioda primećena je 2020. godine, dok je najniža bila 2012. godine. Potrošnja antidijabetika u 2021.
godini iznosila je 92,18 DDD/1000 stanovnika/dan što je za 23,73% više u odnosu na 2012. godinu.
Među ovom grupom lekova dominira upotreba oralnih antidijabetika koji se u proseku primenjuju
4,45 puta više u odnosu na insulin i analoge. Najzastupljeniji lekovi u ukupnoj potrošnji antidijabetika
do 2017. godine bili su sulfonamidi i derivati sulfonilureje kada su u proseku činili 43,39%. Nakon
2017. godine prvo mesto po potrošnji zauzima metformin, čiji udeo u ukupnoj potrošnji
antidijabetika dostiže 48,75% u 2021. godini. Potrošnja novih oralnih antidijabetika je veoma mala i
ne prelazi 0,1% ukupne potrošnje tokom ispitivanog perioda. Ipak najveći porast je primećen u
upotrebi inhibitora natrijum-glukoznog kotransportera 2 (SGLT2) (3,19 DDD/1000 stanovnika/dan
u 2021. godini nasuprot 0,001 DDD/1000 stanovnika/dan u 2015. godini). Rastući trend potrošnje
posebno je izražen kod metformina i SGLT2 inhibitora. Rezultati ukazuju na usklađenost primene
antidijabetika sa preporukama Nacionalnog vodiča.
AB  - As one of the biggest public health challenges, diabetes mellitus represents the reason for the
constant pharmacotherapy improvement (1). Modern therapy of diabetes mellitus can alter the
course of the disease, prevent complications, and contribute to healthcare savings (2). This study
aimed to analyze the consumption of antidiabetic drugs in the Republic of Serbia from 2012 to 2021
and compliance with the recommendations of the National Guide. The consumption of all registered
antidiabetic drugs was obtained from publications of the Medicines and Medical Devices Agency of
Serbia. For each International Nonproprietary Name (INN), consumption was monitored and
expressed in a standardized unit-defined daily dose per 1000 inhabitants per day (DDD/1000
inhabitants/day). During the study period, the highest consumption was observed in 2020, while the
lowest was in 2012. Antidiabetic drug consumption in 2021 amounted to 92.18 DDD/1000
inhabitants/day, which is 23.73% higher compared to 2012. The consumption of oral antidiabetics
was dominant, on average 4.45 times more than insulin and analogs. The most commonly used drugs
until 2017 in total antidiabetic consumption were sulfonylureas and sulfonylurea derivatives,
constituting an average of 43.39%. After 2017, metformin took the lead in consumption, reaching
48.75% of total antidiabetic consumption in 2021. New oral antidiabetic drugs do not exceed 0.1%
of the total consumption during the examined period. However, sodium-glucose cotransporter-2
(SGLT2) inhibitors (3.19 DDD/1000 inhabitants/day in 2021 compared to 0.001 DDD/1000
inhabitants/day in 2015) noted the most significant increase. The increasing consumption trend is
particularly pronounced for metformin and SGLT2 inhibitors. The results indicate compliance in the
use of antidiabetic drugs with the National Guide recommendations.
PB  - Savez farmaceutskih udruženja Srbije
C3  - Arhiv za farmaciju
T1  - Dijabetes u Srbiji: trendovi u potrošnji antidijabetika od 2012. do 2021. godine
T1  - Diabetes in Serbia: trends in antidiabetic drug consumption from 2012 to 2021
VL  - 73
IS  - Suppl. 4
SP  - S51
EP  - S52
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5352
ER  - 
@conference{
author = "Jovanović, Aleksandar and Kundalić, Ana and Miladinović, Bojana and Džodić, Predrag and Catić-Đorđević, Aleksandra and Krajnović, Dušanka and Tadić, Ivana",
year = "2023",
abstract = "Kao jedan od najvećih javnozdravstvenih izazova diabetes mellitus predstavlja razlog
konstantnog unapređenja farmakoterapije (1). Savremena terapija diabetes mellitus-a može
promeniti tok bolesti, prevenirati komplikacije i doprineti uštedi u zdravstvu (2). Cilj rada bio je da
se analizira potrošnja antidijabetika u Srbiji, u periodu od 2012. do 2021. godine i usklađenost sa
preporukama Nacionalnog vodiča. Podaci o potrošnji antidijabetika prikupljeni su iz publikacija
Agencije za lekove i medicinska sredstva Srbije. Za svaki internacionalni nezaštićen naziv (INN),
praćena je potrošnja izražena u standardizovanoj jedinici - definisanoj dnevnoj dozi na 1000
stanovnika u danu (DDD/1000 stanovnika/dan). Najveća potrošnja antidijabetika tokom ispitivanog
perioda primećena je 2020. godine, dok je najniža bila 2012. godine. Potrošnja antidijabetika u 2021.
godini iznosila je 92,18 DDD/1000 stanovnika/dan što je za 23,73% više u odnosu na 2012. godinu.
Među ovom grupom lekova dominira upotreba oralnih antidijabetika koji se u proseku primenjuju
4,45 puta više u odnosu na insulin i analoge. Najzastupljeniji lekovi u ukupnoj potrošnji antidijabetika
do 2017. godine bili su sulfonamidi i derivati sulfonilureje kada su u proseku činili 43,39%. Nakon
2017. godine prvo mesto po potrošnji zauzima metformin, čiji udeo u ukupnoj potrošnji
antidijabetika dostiže 48,75% u 2021. godini. Potrošnja novih oralnih antidijabetika je veoma mala i
ne prelazi 0,1% ukupne potrošnje tokom ispitivanog perioda. Ipak najveći porast je primećen u
upotrebi inhibitora natrijum-glukoznog kotransportera 2 (SGLT2) (3,19 DDD/1000 stanovnika/dan
u 2021. godini nasuprot 0,001 DDD/1000 stanovnika/dan u 2015. godini). Rastući trend potrošnje
posebno je izražen kod metformina i SGLT2 inhibitora. Rezultati ukazuju na usklađenost primene
antidijabetika sa preporukama Nacionalnog vodiča., As one of the biggest public health challenges, diabetes mellitus represents the reason for the
constant pharmacotherapy improvement (1). Modern therapy of diabetes mellitus can alter the
course of the disease, prevent complications, and contribute to healthcare savings (2). This study
aimed to analyze the consumption of antidiabetic drugs in the Republic of Serbia from 2012 to 2021
and compliance with the recommendations of the National Guide. The consumption of all registered
antidiabetic drugs was obtained from publications of the Medicines and Medical Devices Agency of
Serbia. For each International Nonproprietary Name (INN), consumption was monitored and
expressed in a standardized unit-defined daily dose per 1000 inhabitants per day (DDD/1000
inhabitants/day). During the study period, the highest consumption was observed in 2020, while the
lowest was in 2012. Antidiabetic drug consumption in 2021 amounted to 92.18 DDD/1000
inhabitants/day, which is 23.73% higher compared to 2012. The consumption of oral antidiabetics
was dominant, on average 4.45 times more than insulin and analogs. The most commonly used drugs
until 2017 in total antidiabetic consumption were sulfonylureas and sulfonylurea derivatives,
constituting an average of 43.39%. After 2017, metformin took the lead in consumption, reaching
48.75% of total antidiabetic consumption in 2021. New oral antidiabetic drugs do not exceed 0.1%
of the total consumption during the examined period. However, sodium-glucose cotransporter-2
(SGLT2) inhibitors (3.19 DDD/1000 inhabitants/day in 2021 compared to 0.001 DDD/1000
inhabitants/day in 2015) noted the most significant increase. The increasing consumption trend is
particularly pronounced for metformin and SGLT2 inhibitors. The results indicate compliance in the
use of antidiabetic drugs with the National Guide recommendations.",
publisher = "Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Dijabetes u Srbiji: trendovi u potrošnji antidijabetika od 2012. do 2021. godine, Diabetes in Serbia: trends in antidiabetic drug consumption from 2012 to 2021",
volume = "73",
number = "Suppl. 4",
pages = "S51-S52",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5352"
}
Jovanović, A., Kundalić, A., Miladinović, B., Džodić, P., Catić-Đorđević, A., Krajnović, D.,& Tadić, I.. (2023). Dijabetes u Srbiji: trendovi u potrošnji antidijabetika od 2012. do 2021. godine. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije., 73(Suppl. 4), S51-S52.
https://hdl.handle.net/21.15107/rcub_farfar_5352
Jovanović A, Kundalić A, Miladinović B, Džodić P, Catić-Đorđević A, Krajnović D, Tadić I. Dijabetes u Srbiji: trendovi u potrošnji antidijabetika od 2012. do 2021. godine. in Arhiv za farmaciju. 2023;73(Suppl. 4):S51-S52.
https://hdl.handle.net/21.15107/rcub_farfar_5352 .
Jovanović, Aleksandar, Kundalić, Ana, Miladinović, Bojana, Džodić, Predrag, Catić-Đorđević, Aleksandra, Krajnović, Dušanka, Tadić, Ivana, "Dijabetes u Srbiji: trendovi u potrošnji antidijabetika od 2012. do 2021. godine" in Arhiv za farmaciju, 73, no. Suppl. 4 (2023):S51-S52,
https://hdl.handle.net/21.15107/rcub_farfar_5352 .

Awareness of elderly patients on herbal products in Serbia

Jovanović, Aleksandar; Stefanović-Vojinović, Jelena; Petrović, Silvana; Drobac, Milica; Tadić, Ivana; Catić-Đorđević, Aleksandra; Kukić-Marković, Jelena

(The International Pharmaceutical Federation (FIP), 2023)

TY  - CONF
AU  - Jovanović, Aleksandar
AU  - Stefanović-Vojinović, Jelena
AU  - Petrović, Silvana
AU  - Drobac, Milica
AU  - Tadić, Ivana
AU  - Catić-Đorđević, Aleksandra
AU  - Kukić-Marković, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5042
AB  - Background: Although the use of medicinal plants have been known since ancient times, an increased use of herbal products is evident in the last few decades, mainly as a part of self-care treatments. In addition to the positive health effects, the use of herbal products can cause certain side effects as well as interactions with conventional therapy, especially among elderly patients.
Purpose: To examine the awareness, habits and attitudes of elderly patients towards the use of herbal products in the Republic of Serbia.
Method: The quantitative, non-experimental research was conducted using a questionnaire in public pharmacies during February 2020. Patients older than 60 years were included in the study. The study was anonymous, and patients gave informed consent.
Results: The study involved 436 patients, of whom 62.4% were female. Most of the respondents live in the city (72.9%) and have a high school or lower education degree (61.9%). Most patients (32.3%) use herbal products daily, while only 12.1% rarely or never use them. Every fourth patient (24.5%) uses them for treatment, while 69.5% to improve their health. Although the majority of patients purchase herbal products in pharmacies and in health food stores (53.6% and 20.8%, respectively), a significant number (19.3%) collect medicinal plants and prepare herbal preparations themselves. The main sources of information about medicinal plants / herbal products are pharmacists (39.7%) and people from the immediate area (28.4%), followed by the media (18.2%) and physicians (11.1%). Every fourth patient (24.5%) uses herbal products for the treatment of some health issues, while 69.5% of patients use herbal products to improve their health. 48.9% of them believe that herbal products are safe, but with some side effects, while 35.8% believe herbal products are completely free of any side effects. Half of respondents (51.4%) believe that herbal products are as effective as or more effective than synthetic medicines. Less than one-third of patients (29.8%) indicated that they knew the difference between herbal medicinal products and herbal dietary supplements. Still, a third of patients (36.7%) needed additional explanations for the use of herbal products. 76.6% of patients stated that they always receive advice from a pharmacist when purchasing herbal products.
Conclusion: The survey conducted in this work showed that elderly patients use herbal products to a considerable extent, which means that it is necessary to educate elderly patients on this matter. Pharmacists should play a vital role in this process and actively discuss the characteristics and proper use of herbal products with patients, especially having in mind the high possibility of interactions with conventional medicines and occurrence of side effects. Since the quality of some herbal products sometimes could be questionable, especially non-regulated ones, patients should be encouraged to purchase them from pharmacies and consult with pharmacists.
PB  - The International Pharmaceutical Federation (FIP)
C3  - Pharmacy Education
T1  - Awareness of elderly patients on herbal products in Serbia
VL  - 23
IS  - 5
SP  - 29
EP  - 29
DO  - 10.46542/pe.2023.235.138
ER  - 
@conference{
author = "Jovanović, Aleksandar and Stefanović-Vojinović, Jelena and Petrović, Silvana and Drobac, Milica and Tadić, Ivana and Catić-Đorđević, Aleksandra and Kukić-Marković, Jelena",
year = "2023",
abstract = "Background: Although the use of medicinal plants have been known since ancient times, an increased use of herbal products is evident in the last few decades, mainly as a part of self-care treatments. In addition to the positive health effects, the use of herbal products can cause certain side effects as well as interactions with conventional therapy, especially among elderly patients.
Purpose: To examine the awareness, habits and attitudes of elderly patients towards the use of herbal products in the Republic of Serbia.
Method: The quantitative, non-experimental research was conducted using a questionnaire in public pharmacies during February 2020. Patients older than 60 years were included in the study. The study was anonymous, and patients gave informed consent.
Results: The study involved 436 patients, of whom 62.4% were female. Most of the respondents live in the city (72.9%) and have a high school or lower education degree (61.9%). Most patients (32.3%) use herbal products daily, while only 12.1% rarely or never use them. Every fourth patient (24.5%) uses them for treatment, while 69.5% to improve their health. Although the majority of patients purchase herbal products in pharmacies and in health food stores (53.6% and 20.8%, respectively), a significant number (19.3%) collect medicinal plants and prepare herbal preparations themselves. The main sources of information about medicinal plants / herbal products are pharmacists (39.7%) and people from the immediate area (28.4%), followed by the media (18.2%) and physicians (11.1%). Every fourth patient (24.5%) uses herbal products for the treatment of some health issues, while 69.5% of patients use herbal products to improve their health. 48.9% of them believe that herbal products are safe, but with some side effects, while 35.8% believe herbal products are completely free of any side effects. Half of respondents (51.4%) believe that herbal products are as effective as or more effective than synthetic medicines. Less than one-third of patients (29.8%) indicated that they knew the difference between herbal medicinal products and herbal dietary supplements. Still, a third of patients (36.7%) needed additional explanations for the use of herbal products. 76.6% of patients stated that they always receive advice from a pharmacist when purchasing herbal products.
Conclusion: The survey conducted in this work showed that elderly patients use herbal products to a considerable extent, which means that it is necessary to educate elderly patients on this matter. Pharmacists should play a vital role in this process and actively discuss the characteristics and proper use of herbal products with patients, especially having in mind the high possibility of interactions with conventional medicines and occurrence of side effects. Since the quality of some herbal products sometimes could be questionable, especially non-regulated ones, patients should be encouraged to purchase them from pharmacies and consult with pharmacists.",
publisher = "The International Pharmaceutical Federation (FIP)",
journal = "Pharmacy Education",
title = "Awareness of elderly patients on herbal products in Serbia",
volume = "23",
number = "5",
pages = "29-29",
doi = "10.46542/pe.2023.235.138"
}
Jovanović, A., Stefanović-Vojinović, J., Petrović, S., Drobac, M., Tadić, I., Catić-Đorđević, A.,& Kukić-Marković, J.. (2023). Awareness of elderly patients on herbal products in Serbia. in Pharmacy Education
The International Pharmaceutical Federation (FIP)., 23(5), 29-29.
https://doi.org/10.46542/pe.2023.235.138
Jovanović A, Stefanović-Vojinović J, Petrović S, Drobac M, Tadić I, Catić-Đorđević A, Kukić-Marković J. Awareness of elderly patients on herbal products in Serbia. in Pharmacy Education. 2023;23(5):29-29.
doi:10.46542/pe.2023.235.138 .
Jovanović, Aleksandar, Stefanović-Vojinović, Jelena, Petrović, Silvana, Drobac, Milica, Tadić, Ivana, Catić-Đorđević, Aleksandra, Kukić-Marković, Jelena, "Awareness of elderly patients on herbal products in Serbia" in Pharmacy Education, 23, no. 5 (2023):29-29,
https://doi.org/10.46542/pe.2023.235.138 . .

Mobile Health applications - untapped potential

Koraćević, Maja; Jovanović, Aleksandar; Pavlović, Dragana; Catić-Đorđević, Aleksandra

(Savez farmaceutskih udruženja Srbije (SFUS), 2022)

TY  - CONF
AU  - Koraćević, Maja
AU  - Jovanović, Aleksandar
AU  - Pavlović, Dragana
AU  - Catić-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4554
AB  - Today, there are a number of applications that allow you to monitor physical activity
and health parameters or schedule a medical examination, and can also help you recognize a
health problem and react in time (1, 2). The aim of the present study was to assess the usage
of health applications (HApps, health-related mobile and/or web applications) among
citizens in Serbia.
The anonymous online questionnaire was distributed via social media in the spring of
2020. Data were processed using the IBM SPSS. 506 respondents participated in the
research, of which 155 were from the health profession. The majority of respondents were
female (73.9%), and the average age was 36.88 ± 11.22. About half of the respondents
(48.2%) have a university degree, and 74.9% are employed. Installed HApps on
phone/computer have 18.2% of respondents, with a statistically significant difference (p
<0.01) between health professionals (25.8%) and non-health (14.8%). The most commonly
used HApps among health professionals are those related to their professional work
(14.7%), followed by general health (3.8%) and specific diseases (1.9%). Non-health
professional respondents mostly used applications related to general health (5.4%), fitness
(2.0%) and the chosen doctor (1.4%). Only 0.6% of citizens used COVID-19 pandemic
applications. The importance of HApps is still not sufficiently recognized in Serbia. Given the
potential in controlling chronic diseases and other health conditions, especially among a
population with limited access to health care and health information, they should be more
integrated into the health system.
AB  - Danas postoji niz aplikacija koje omogućavaju praćenje fizičke aktivnosti i
zdravstvenih parametara ili zakazivanje lekarskog pregleda, a mogu pomoći i u
prepoznavanju zdravstvenih problema obaveštavajući vas da reagujete na vreme (1, 2). Cilj
ove studije bio je da ispita upotrebu zdravstvenih aplikacija (HApps, mobilne i/ili web
aplikacije u vezi sa zdravljem) među građanima Srbije. Anonimni onlajn upitnik distribuiran
je putem društvenih mreža tokom proleća 2020. godine. Podaci su obrađeni korišćenjem
IBM SPSS. U istraživanju je učestvovalo 506 ispitanika, od kojih 155 iz zdravstvene struke.
Većina ispitanika su žene (73.9%), a prosečna starost bila je 36.88±11.22 godina. Oko
polovine ispitanika (48.2%) ima fakultetsko obrazovanje, a 74.9% je zaposleno. Instalirane
HApps na svom telefonu/računaru ima 18.2% ispitanika, sa statistički značajnom razlikom
(p<0.01) među ispitanicima iz zdravstvene struke (25.8%) i onih koji to nisu (14.8%).
Najkorišćenije HApps među ispitanicima zdravstvene struke su one koje se odnose na njihov
stručni rad (14.7%), opšte zdravlje (3.8%) i specifične bolesti (1.9%). Ispitanici koji nisu iz
zdravstvene struke najviše su koristili aplikacije koje se odnose na opšte zdravlje (5.4%),
fitnes (2.0%) i izabranog lekara (1.4%). Aplikacije u vezi sa COVID-19 pandemijom koristilo
je svega 0.6% građana. Značaj HApps još uvek nije dovoljno prepoznat u Srbiji. S obzirom na
potencijal u kontroli hroničnih bolesti i drugih zdravstvenih stanja, naročito među
populacijom sa ograničenim pristupom zdravstvenoj zaštiti i zdravstvenim informacijama,
trebalo bi ih više integrisati u zdravstveni sistem.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Mobile Health applications - untapped potential
T1  - Zdravstvene aplikacije – neiskorišćen potencijal
VL  - 72
IS  - 4 suplement
SP  - S347
EP  - S348
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4554
ER  - 
@conference{
author = "Koraćević, Maja and Jovanović, Aleksandar and Pavlović, Dragana and Catić-Đorđević, Aleksandra",
year = "2022",
abstract = "Today, there are a number of applications that allow you to monitor physical activity
and health parameters or schedule a medical examination, and can also help you recognize a
health problem and react in time (1, 2). The aim of the present study was to assess the usage
of health applications (HApps, health-related mobile and/or web applications) among
citizens in Serbia.
The anonymous online questionnaire was distributed via social media in the spring of
2020. Data were processed using the IBM SPSS. 506 respondents participated in the
research, of which 155 were from the health profession. The majority of respondents were
female (73.9%), and the average age was 36.88 ± 11.22. About half of the respondents
(48.2%) have a university degree, and 74.9% are employed. Installed HApps on
phone/computer have 18.2% of respondents, with a statistically significant difference (p
<0.01) between health professionals (25.8%) and non-health (14.8%). The most commonly
used HApps among health professionals are those related to their professional work
(14.7%), followed by general health (3.8%) and specific diseases (1.9%). Non-health
professional respondents mostly used applications related to general health (5.4%), fitness
(2.0%) and the chosen doctor (1.4%). Only 0.6% of citizens used COVID-19 pandemic
applications. The importance of HApps is still not sufficiently recognized in Serbia. Given the
potential in controlling chronic diseases and other health conditions, especially among a
population with limited access to health care and health information, they should be more
integrated into the health system., Danas postoji niz aplikacija koje omogućavaju praćenje fizičke aktivnosti i
zdravstvenih parametara ili zakazivanje lekarskog pregleda, a mogu pomoći i u
prepoznavanju zdravstvenih problema obaveštavajući vas da reagujete na vreme (1, 2). Cilj
ove studije bio je da ispita upotrebu zdravstvenih aplikacija (HApps, mobilne i/ili web
aplikacije u vezi sa zdravljem) među građanima Srbije. Anonimni onlajn upitnik distribuiran
je putem društvenih mreža tokom proleća 2020. godine. Podaci su obrađeni korišćenjem
IBM SPSS. U istraživanju je učestvovalo 506 ispitanika, od kojih 155 iz zdravstvene struke.
Većina ispitanika su žene (73.9%), a prosečna starost bila je 36.88±11.22 godina. Oko
polovine ispitanika (48.2%) ima fakultetsko obrazovanje, a 74.9% je zaposleno. Instalirane
HApps na svom telefonu/računaru ima 18.2% ispitanika, sa statistički značajnom razlikom
(p<0.01) među ispitanicima iz zdravstvene struke (25.8%) i onih koji to nisu (14.8%).
Najkorišćenije HApps među ispitanicima zdravstvene struke su one koje se odnose na njihov
stručni rad (14.7%), opšte zdravlje (3.8%) i specifične bolesti (1.9%). Ispitanici koji nisu iz
zdravstvene struke najviše su koristili aplikacije koje se odnose na opšte zdravlje (5.4%),
fitnes (2.0%) i izabranog lekara (1.4%). Aplikacije u vezi sa COVID-19 pandemijom koristilo
je svega 0.6% građana. Značaj HApps još uvek nije dovoljno prepoznat u Srbiji. S obzirom na
potencijal u kontroli hroničnih bolesti i drugih zdravstvenih stanja, naročito među
populacijom sa ograničenim pristupom zdravstvenoj zaštiti i zdravstvenim informacijama,
trebalo bi ih više integrisati u zdravstveni sistem.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Mobile Health applications - untapped potential, Zdravstvene aplikacije – neiskorišćen potencijal",
volume = "72",
number = "4 suplement",
pages = "S347-S348",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4554"
}
Koraćević, M., Jovanović, A., Pavlović, D.,& Catić-Đorđević, A.. (2022). Mobile Health applications - untapped potential. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S347-S348.
https://hdl.handle.net/21.15107/rcub_farfar_4554
Koraćević M, Jovanović A, Pavlović D, Catić-Đorđević A. Mobile Health applications - untapped potential. in Arhiv za farmaciju. 2022;72(4 suplement):S347-S348.
https://hdl.handle.net/21.15107/rcub_farfar_4554 .
Koraćević, Maja, Jovanović, Aleksandar, Pavlović, Dragana, Catić-Đorđević, Aleksandra, "Mobile Health applications - untapped potential" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S347-S348,
https://hdl.handle.net/21.15107/rcub_farfar_4554 .

Antibiotic use in therapy of urinary tract infections

Jovanović, Aleksandar; Šesto, Sofija; Odalović, Marina; Lakić, Dragana; Stević, Ivana; Krajnović, Dušanka; Tadić, Ivana

(Savez farmaceutskih udruženja Srbije (SFUS), 2022)

TY  - CONF
AU  - Jovanović, Aleksandar
AU  - Šesto, Sofija
AU  - Odalović, Marina
AU  - Lakić, Dragana
AU  - Stević, Ivana
AU  - Krajnović, Dušanka
AU  - Tadić, Ivana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4547
AB  - Antibiotics are the gold standard in treating and preventing recurrent urinary tract
infections (UTIs), but their widespread, irrational use leads to the development of
antimicrobial resistance (1,2). The aim of this study was to analyze the use of antibiotics in
patients with UTIs symptoms. An online survey for patients was disseminated by
researchers and community pharmacists during the winter 2020/21. The study was
approved by the Ethical Committee of the University of Belgrade – Faculty of Pharmacy. The
study included 736 respondents, 31.5 years of age in average, and most of them were women
(80.8%). Approximately 40% of patients reported that they experienced symptoms of UTIs
in previous years, and 49.3% of patients did not seek a counsel of health care professionals,
and rather had used therapy following the advice of friends, family members or by their
opinion. A smaller number of patients used antibiotics in therapy (n=178, 24.2%) prescribed
by the doctor (79.2% of patients), and in some cases without prior consultation with a doctor
(20.8% of patients). Antibiotics successfully treated 70% of UTIs. According to data collected
from 133 patients, 17 different antibiotics were used in UTI treatment. The most used
antibiotics were: ciprofloxacin (23.3%), cephalexin (17.3%) and fosfomycin (14.3%).
Antibiotics used for UTIs treatment didn’t comply with the European Association of Urology
guidelines. Considering that the use of medicines could be initiated by patients and therefore
be unreported, the use of medicines for UTIs should be analysed both from clinical patients’
data records and individual patients’ reports.
AB  - Antibiotici predstavljaju zlatni standard u lečenju i prevenciji rekurentnih infekcija
urinarnog trakta (IUT), ali njihova učestala, neracionalna upotreba dovodi do razvoja
antimikrobne rezistencije (1,2). Cilj ovog istraživanja bio je da se analizira upotreba
antibiotika kod pacijenata sa simptomima IUT. Istraživači i farmaceuti u javnim apotekama
su distribuirali pacijentima onlajn anketu tokom zime 2020/21. Studiju je odobrila Etička
komisija Farmaceutskog fakulteta – Univerziteta u Beogradu. Istraživanjem je obuhvaćeno
736 ispitanika, prosečne starosti 31,5 godina, među kojima su najviše bile žene (80,8%).
Približno 40% pacijenata je izjavilo da su imali simptome IUT tokom prethodne godine, od
kojih 49,3% pacijenata nije tražilo savet zdravstvenih profesionalaca, već je koristilo terapiju
po savetu prijatelja, članova porodice ili po njihovom sopstvenom mišljenju. Manji broj
pacijenata koristio je antibiotike u terapiji (n=178, 24,2%) na osnovu lekarskog recepta
(79,2% pacijenata), a u pojedinim slučajevima i bez prethodne konsultacije sa lekarom
(20,8% pacijenata). Antibiotici su uspešno lečili 70% IUT. Prema podacima prikupljenim od
133 pacijenta, u lečenju IUT korišćeno je 17 različitih antibiotika. Najviše korišćeni
antibiotici su: ciprofloksacin (23,3%), cefaleksin (17,3%) i fosfomicin (14,3%). Antibiotici
koji su korišćeni za lečenje IUT nisu bili u skladu sa smernicama Evropskog udruženja za
urologiju. Budući da pacijenti u nekim slučajevima sami započinju terapiju bez prethodne
konsultacije sa lekarima, upotrebu lekova za IUT treba analizirati kako na osnovu kliničkih
podataka pacijenata, tako i iz izveštaja pojedinačnih pacijenata.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Antibiotic use in therapy of urinary tract infections
T1  - Upotreba antibiotika u terapiji infekcija urinarnog trakta
VL  - 72
IS  - 4 suplement
SP  - S341
EP  - S342
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4547
ER  - 
@conference{
author = "Jovanović, Aleksandar and Šesto, Sofija and Odalović, Marina and Lakić, Dragana and Stević, Ivana and Krajnović, Dušanka and Tadić, Ivana",
year = "2022",
abstract = "Antibiotics are the gold standard in treating and preventing recurrent urinary tract
infections (UTIs), but their widespread, irrational use leads to the development of
antimicrobial resistance (1,2). The aim of this study was to analyze the use of antibiotics in
patients with UTIs symptoms. An online survey for patients was disseminated by
researchers and community pharmacists during the winter 2020/21. The study was
approved by the Ethical Committee of the University of Belgrade – Faculty of Pharmacy. The
study included 736 respondents, 31.5 years of age in average, and most of them were women
(80.8%). Approximately 40% of patients reported that they experienced symptoms of UTIs
in previous years, and 49.3% of patients did not seek a counsel of health care professionals,
and rather had used therapy following the advice of friends, family members or by their
opinion. A smaller number of patients used antibiotics in therapy (n=178, 24.2%) prescribed
by the doctor (79.2% of patients), and in some cases without prior consultation with a doctor
(20.8% of patients). Antibiotics successfully treated 70% of UTIs. According to data collected
from 133 patients, 17 different antibiotics were used in UTI treatment. The most used
antibiotics were: ciprofloxacin (23.3%), cephalexin (17.3%) and fosfomycin (14.3%).
Antibiotics used for UTIs treatment didn’t comply with the European Association of Urology
guidelines. Considering that the use of medicines could be initiated by patients and therefore
be unreported, the use of medicines for UTIs should be analysed both from clinical patients’
data records and individual patients’ reports., Antibiotici predstavljaju zlatni standard u lečenju i prevenciji rekurentnih infekcija
urinarnog trakta (IUT), ali njihova učestala, neracionalna upotreba dovodi do razvoja
antimikrobne rezistencije (1,2). Cilj ovog istraživanja bio je da se analizira upotreba
antibiotika kod pacijenata sa simptomima IUT. Istraživači i farmaceuti u javnim apotekama
su distribuirali pacijentima onlajn anketu tokom zime 2020/21. Studiju je odobrila Etička
komisija Farmaceutskog fakulteta – Univerziteta u Beogradu. Istraživanjem je obuhvaćeno
736 ispitanika, prosečne starosti 31,5 godina, među kojima su najviše bile žene (80,8%).
Približno 40% pacijenata je izjavilo da su imali simptome IUT tokom prethodne godine, od
kojih 49,3% pacijenata nije tražilo savet zdravstvenih profesionalaca, već je koristilo terapiju
po savetu prijatelja, članova porodice ili po njihovom sopstvenom mišljenju. Manji broj
pacijenata koristio je antibiotike u terapiji (n=178, 24,2%) na osnovu lekarskog recepta
(79,2% pacijenata), a u pojedinim slučajevima i bez prethodne konsultacije sa lekarom
(20,8% pacijenata). Antibiotici su uspešno lečili 70% IUT. Prema podacima prikupljenim od
133 pacijenta, u lečenju IUT korišćeno je 17 različitih antibiotika. Najviše korišćeni
antibiotici su: ciprofloksacin (23,3%), cefaleksin (17,3%) i fosfomicin (14,3%). Antibiotici
koji su korišćeni za lečenje IUT nisu bili u skladu sa smernicama Evropskog udruženja za
urologiju. Budući da pacijenti u nekim slučajevima sami započinju terapiju bez prethodne
konsultacije sa lekarima, upotrebu lekova za IUT treba analizirati kako na osnovu kliničkih
podataka pacijenata, tako i iz izveštaja pojedinačnih pacijenata.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Antibiotic use in therapy of urinary tract infections, Upotreba antibiotika u terapiji infekcija urinarnog trakta",
volume = "72",
number = "4 suplement",
pages = "S341-S342",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4547"
}
Jovanović, A., Šesto, S., Odalović, M., Lakić, D., Stević, I., Krajnović, D.,& Tadić, I.. (2022). Antibiotic use in therapy of urinary tract infections. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S341-S342.
https://hdl.handle.net/21.15107/rcub_farfar_4547
Jovanović A, Šesto S, Odalović M, Lakić D, Stević I, Krajnović D, Tadić I. Antibiotic use in therapy of urinary tract infections. in Arhiv za farmaciju. 2022;72(4 suplement):S341-S342.
https://hdl.handle.net/21.15107/rcub_farfar_4547 .
Jovanović, Aleksandar, Šesto, Sofija, Odalović, Marina, Lakić, Dragana, Stević, Ivana, Krajnović, Dušanka, Tadić, Ivana, "Antibiotic use in therapy of urinary tract infections" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S341-S342,
https://hdl.handle.net/21.15107/rcub_farfar_4547 .

Historical overview of quinine isolation and its importance

Jovanović, Aleksandar; Krajnović, Dušanka

(Savez farmaceutskih udruženja Srbije (SFUS), 2022)

TY  - CONF
AU  - Jovanović, Aleksandar
AU  - Krajnović, Dušanka
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4500
AB  - The use of quinine bark was first documented in 1630 by Jesuit missionaries, after
which it occupied the great attention of scientists (1). In 1746 Count Claude Toussaint Marot
de la Garaye was the first to crystallize a substance from quinine bark and called it "sel
essentiel de quinquina", which was later found to have no clinical effects. With the
development of acid-base extraction procedures, in 1820, two French scientists, pharmacists
Pierre Pelletier and Joseph Caventou, isolated the active substance and called it quinine.
They used the "yellow" bark of quinine, which was known to be more effective against
malaria than the "gray" bark used by scientists in previous attempts at isolation. Having
received numerous awards and honors, these two scientists established a factory in Paris for
the extraction of quinine, an activity that is often mentioned as the beginning of the modern
pharmaceutical industry. After isolation, doctors confirmed its efficacy and specificity in the
treatment of malarial fever, making quinine preparations become part of the official Materia
medica. Isolation enabled quantitative assessment of bark quality, more precise dosing and
higher efficiency (1,2). Quinidine, cinchonine and cinchonidine are isolated after quinine, and
the effectiveness of these four alkaloids was evaluated in one of the earliest clinical trials,
conducted from 1866 to 1868 on 3,600 subjects. Quinine is included in a number of
pharmacopoeias, and the Pharmacopée universelle describes more than 100 official quinine-
based preparations for the treatment of a large number of diseases (2).
AB  - Primena kore hininovca prvi put je dokumentovana 1630. godine od strane Jezuitskih
misionara, nakon čega ova biljna droga okupira veliku pažnju naučnika (1). Godine 1746.
grof Claude Toussaint Marot de la Garaye prvi izoluje supstancu iz kore hininovca i nazvava
je “sel essentiel de quinquina”, za koju se kasnije utvrđuje da nema kliničke efekte. Sa
razvojem postupaka kiselinsko-bazne ekstrakcije, 1820. godine dva francuska naučnika,
farmaceuti Pierre Pelletier i Joseph Caventou konačno izoluju aktivnu supstancu i nazivaju je
hinin. U ovom eksperimentu koristili su „žutu“ koru hininovca, za koju se znalo da je
efikasnija protiv malarije od „sive“ kore koju su koristili naučnici u brojnim prethodnim
pokušajima izolacije. Dobivši brojne nagrade i počasti, ova dva naučnika u Parizu otvaraju
fabriku za ekstrakciju hinina, delatnost koja se često pominje kao početak moderne
farmaceutske industrije. Ubrzo nakon izolacije lekari potvrđuju njegovu efikasnost i
specifičnost u terapiji malaričnih groznica čime preparati hinina postaju deo oficinalne
Matrije medike. Izolacija je omogućila kvantitativnu procenu kvaliteta kore, preciznije
doziranje i veću efikasnost (1,2). Nakon hinina bivaju izolovani i hinidin, cinhonin i
cinhonidin, a efikasnost ova četiri alkaloida procenjena je u jednom od najranijih kliničkih
ispitivanja, sprovedenih od 1866. do 1868. godine na 3600 ispitanika. Hinin ulazi i u brojne
farmakopeje, a Pharmacopée universelle opisuje više od 100 zvaničnih preparata zasnovanih
na hininu za terapiju velikog broja bolesti (2).
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Historical overview of quinine isolation and its importance
T1  - Istorijski pregled izolovanja hinina i njegov značaj
VL  - 72
IS  - 4 suplement
SP  - S219
EP  - S220
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4500
ER  - 
@conference{
author = "Jovanović, Aleksandar and Krajnović, Dušanka",
year = "2022",
abstract = "The use of quinine bark was first documented in 1630 by Jesuit missionaries, after
which it occupied the great attention of scientists (1). In 1746 Count Claude Toussaint Marot
de la Garaye was the first to crystallize a substance from quinine bark and called it "sel
essentiel de quinquina", which was later found to have no clinical effects. With the
development of acid-base extraction procedures, in 1820, two French scientists, pharmacists
Pierre Pelletier and Joseph Caventou, isolated the active substance and called it quinine.
They used the "yellow" bark of quinine, which was known to be more effective against
malaria than the "gray" bark used by scientists in previous attempts at isolation. Having
received numerous awards and honors, these two scientists established a factory in Paris for
the extraction of quinine, an activity that is often mentioned as the beginning of the modern
pharmaceutical industry. After isolation, doctors confirmed its efficacy and specificity in the
treatment of malarial fever, making quinine preparations become part of the official Materia
medica. Isolation enabled quantitative assessment of bark quality, more precise dosing and
higher efficiency (1,2). Quinidine, cinchonine and cinchonidine are isolated after quinine, and
the effectiveness of these four alkaloids was evaluated in one of the earliest clinical trials,
conducted from 1866 to 1868 on 3,600 subjects. Quinine is included in a number of
pharmacopoeias, and the Pharmacopée universelle describes more than 100 official quinine-
based preparations for the treatment of a large number of diseases (2)., Primena kore hininovca prvi put je dokumentovana 1630. godine od strane Jezuitskih
misionara, nakon čega ova biljna droga okupira veliku pažnju naučnika (1). Godine 1746.
grof Claude Toussaint Marot de la Garaye prvi izoluje supstancu iz kore hininovca i nazvava
je “sel essentiel de quinquina”, za koju se kasnije utvrđuje da nema kliničke efekte. Sa
razvojem postupaka kiselinsko-bazne ekstrakcije, 1820. godine dva francuska naučnika,
farmaceuti Pierre Pelletier i Joseph Caventou konačno izoluju aktivnu supstancu i nazivaju je
hinin. U ovom eksperimentu koristili su „žutu“ koru hininovca, za koju se znalo da je
efikasnija protiv malarije od „sive“ kore koju su koristili naučnici u brojnim prethodnim
pokušajima izolacije. Dobivši brojne nagrade i počasti, ova dva naučnika u Parizu otvaraju
fabriku za ekstrakciju hinina, delatnost koja se često pominje kao početak moderne
farmaceutske industrije. Ubrzo nakon izolacije lekari potvrđuju njegovu efikasnost i
specifičnost u terapiji malaričnih groznica čime preparati hinina postaju deo oficinalne
Matrije medike. Izolacija je omogućila kvantitativnu procenu kvaliteta kore, preciznije
doziranje i veću efikasnost (1,2). Nakon hinina bivaju izolovani i hinidin, cinhonin i
cinhonidin, a efikasnost ova četiri alkaloida procenjena je u jednom od najranijih kliničkih
ispitivanja, sprovedenih od 1866. do 1868. godine na 3600 ispitanika. Hinin ulazi i u brojne
farmakopeje, a Pharmacopée universelle opisuje više od 100 zvaničnih preparata zasnovanih
na hininu za terapiju velikog broja bolesti (2).",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Historical overview of quinine isolation and its importance, Istorijski pregled izolovanja hinina i njegov značaj",
volume = "72",
number = "4 suplement",
pages = "S219-S220",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4500"
}
Jovanović, A.,& Krajnović, D.. (2022). Historical overview of quinine isolation and its importance. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S219-S220.
https://hdl.handle.net/21.15107/rcub_farfar_4500
Jovanović A, Krajnović D. Historical overview of quinine isolation and its importance. in Arhiv za farmaciju. 2022;72(4 suplement):S219-S220.
https://hdl.handle.net/21.15107/rcub_farfar_4500 .
Jovanović, Aleksandar, Krajnović, Dušanka, "Historical overview of quinine isolation and its importance" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S219-S220,
https://hdl.handle.net/21.15107/rcub_farfar_4500 .

Awareness of patients in the city of Belgrade about herbal products

Jovanović, Aleksandar; Stefanović-Vojinović, Jelena; Kukić-Marković, Jelena; Petrović, Silvana; Drobac, Milica; Tadić, Ivana

(2022)

TY  - CONF
AU  - Jovanović, Aleksandar
AU  - Stefanović-Vojinović, Jelena
AU  - Kukić-Marković, Jelena
AU  - Petrović, Silvana
AU  - Drobac, Milica
AU  - Tadić, Ivana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4424
AB  - The use of medicinal plants has significant impact on human health (1,2). Approximately 13.000 medicinal plants are used worldwide (1), and in developing countries 65-80% of the population uses them for medicinal purposes (2). 
The aim of the study was to examine the awareness of patients in the city of Belgrade about herbal products. Quantitative, non-experimental research was conducted using a purpose-built questionnaire in public pharmacies during February 2020.
The survey involved 954 respondents, mostly women (66.5%); 39.1% of respondents aged 20-40 years. Most of the respondents were employed (65.2%), with secondary school education (45.2%). The vast majority (97.3%) used medicinal plants/herbal products, mostly occasionally, as needed (38.4%). The main motive for their use was health improvement (75.2%), while 16.2% used them to treat diseases. The primary sources of information on medicinal plants/herbal products are pharmacists (45.1%) and the media (24.2%). About a third of the respondents (37.3%) stated that they knew the difference between herbal medicinal products and dietary supplements. 52.9% of respondents claimed that herbal medicinal products are effective, but less than synthetic drugs, while 61.5% claimed that they are safe, but with certain side effects. A third of respondents (32.9%) had difficulty understanding instructions for use and they needed additional explanations. Majority (70.6%) received advice from a pharmacist when buying a herbal product.
Pharmacists are health professionals who have adequate knowledge of medicinal plants/herbal products and have a key role in advising patients in order to implement the proper use of herbal medicinal and other herbal products.

References
1. Capasso F, Gaginella TS, Grandolini G, Izzo AA. Phytotherapy: a quick reference to herbal medicine. Springer Science & Business Media. 2003.
2. Palhares RM, Gonçalves Drummond M, dos Santos Alves Figueiredo Brasil B, Pereira Cosenza G, das Graças Lins Brandão M, Oliveira G. Medicinal plants recommended by the World Health Organization: DNA barcode identification associated with chemical analyses guarantees their quality. PloS one. 2015;10(5), e0127866.

Acknowledgements
This research was conducted with help and support of Pharmacy „Lilly Drogerie“ and funded by the Ministry of Education, Science and Technological Development, Republic of Serbia through Grant Agreement with University of Belgrade-Faculty of Pharmacy No: 451-03-68/2022-14/200161.
AB  - Primena lekovitih biljaka ima značajan uticaj na ljudsko zdravlje (1,2). U svetu se
koristi oko 13 000 lekovitih biljaka (1), a u zemljama u razvoju 65-80% populacije ih
primenjuje u medicinske svrhe (2). Cilj rada bio je ispitivanje informisanosti pacijenata na
teritoriji grada Beograda o biljnim proizvodima. Sprovedeno je kvantitativno,
neeksperimentalno istraživanje pomoću namenski kreiranog upitnika u javnim apotekama
tokom februara 2020. godine. U istraživanju je učestvovalo 954 ispitanika, od koji 66,5%
ženskog pola; 39,1% starosti 20-40 godina. Većina je bila zaposlena (65,2%), sa
srednjoškolskim obrazovanjem (45,2%). Najveći broj ispitanika (97,3%) je koristio lekovite
biljke/biljne proizvode i to uglavnom povremeno, po potrebi (38,4%). Glavni motiv za
njihovo korišćenje bio je poboljšanje zdravlja (75,2%), dok ih je 16,2% koristilo za lečenje.
Ispitanici su se o delovanju i upotrebi lekovitih biljaka/biljnih proizvoda uglavnom
informisali od farmaceuta u apotekama (45,1%) i putem medija (24,2%). Oko trećine
ispitanika (37,3%) je navelo da zna razliku između biljnih lekovitih proizvoda i dijetetskih
suplemenata. Da su biljni lekoviti proizvodi efikasni, ali manje od sintetskih lekova, smatralo
je 52,9% ispitanika, dok je 61,5% smatralo da su oni bezbedni za upotrebu, ali sa mogućim
neželjenim efektima. Trećina anketiranih (32,9%) imala je poteškoće da razume uputstva za
upotrebu biljnih proizvoda, te su im bila potrebna dodatna objašnjenja. Najveći deo
ispitanika (70,6%) dobijao je savet farmaceuta pri kupovini biljnog proizvoda. Farmaceuti su
zdravstveni profesionalci koji poseduju adekvatna znanja o lekovitim biljkama/biljnim
proizvodima i imaju ključnu ulogu u savetovanju pacijenata u cilju sprovođenja pravilne
primene biljnih lekovitih i drugih biljnih proizvoda.
C3  - Arhiv za farmaciju
T1  - Awareness of patients in the city of Belgrade about herbal products
T1  - Informisanost pacijenata na teritoriji grada Beograda o biljnim proizvodima
VL  - 72
IS  - 4 suplement
SP  - S473
EP  - S474
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4424
ER  - 
@conference{
author = "Jovanović, Aleksandar and Stefanović-Vojinović, Jelena and Kukić-Marković, Jelena and Petrović, Silvana and Drobac, Milica and Tadić, Ivana",
year = "2022",
abstract = "The use of medicinal plants has significant impact on human health (1,2). Approximately 13.000 medicinal plants are used worldwide (1), and in developing countries 65-80% of the population uses them for medicinal purposes (2). 
The aim of the study was to examine the awareness of patients in the city of Belgrade about herbal products. Quantitative, non-experimental research was conducted using a purpose-built questionnaire in public pharmacies during February 2020.
The survey involved 954 respondents, mostly women (66.5%); 39.1% of respondents aged 20-40 years. Most of the respondents were employed (65.2%), with secondary school education (45.2%). The vast majority (97.3%) used medicinal plants/herbal products, mostly occasionally, as needed (38.4%). The main motive for their use was health improvement (75.2%), while 16.2% used them to treat diseases. The primary sources of information on medicinal plants/herbal products are pharmacists (45.1%) and the media (24.2%). About a third of the respondents (37.3%) stated that they knew the difference between herbal medicinal products and dietary supplements. 52.9% of respondents claimed that herbal medicinal products are effective, but less than synthetic drugs, while 61.5% claimed that they are safe, but with certain side effects. A third of respondents (32.9%) had difficulty understanding instructions for use and they needed additional explanations. Majority (70.6%) received advice from a pharmacist when buying a herbal product.
Pharmacists are health professionals who have adequate knowledge of medicinal plants/herbal products and have a key role in advising patients in order to implement the proper use of herbal medicinal and other herbal products.

References
1. Capasso F, Gaginella TS, Grandolini G, Izzo AA. Phytotherapy: a quick reference to herbal medicine. Springer Science & Business Media. 2003.
2. Palhares RM, Gonçalves Drummond M, dos Santos Alves Figueiredo Brasil B, Pereira Cosenza G, das Graças Lins Brandão M, Oliveira G. Medicinal plants recommended by the World Health Organization: DNA barcode identification associated with chemical analyses guarantees their quality. PloS one. 2015;10(5), e0127866.

Acknowledgements
This research was conducted with help and support of Pharmacy „Lilly Drogerie“ and funded by the Ministry of Education, Science and Technological Development, Republic of Serbia through Grant Agreement with University of Belgrade-Faculty of Pharmacy No: 451-03-68/2022-14/200161., Primena lekovitih biljaka ima značajan uticaj na ljudsko zdravlje (1,2). U svetu se
koristi oko 13 000 lekovitih biljaka (1), a u zemljama u razvoju 65-80% populacije ih
primenjuje u medicinske svrhe (2). Cilj rada bio je ispitivanje informisanosti pacijenata na
teritoriji grada Beograda o biljnim proizvodima. Sprovedeno je kvantitativno,
neeksperimentalno istraživanje pomoću namenski kreiranog upitnika u javnim apotekama
tokom februara 2020. godine. U istraživanju je učestvovalo 954 ispitanika, od koji 66,5%
ženskog pola; 39,1% starosti 20-40 godina. Većina je bila zaposlena (65,2%), sa
srednjoškolskim obrazovanjem (45,2%). Najveći broj ispitanika (97,3%) je koristio lekovite
biljke/biljne proizvode i to uglavnom povremeno, po potrebi (38,4%). Glavni motiv za
njihovo korišćenje bio je poboljšanje zdravlja (75,2%), dok ih je 16,2% koristilo za lečenje.
Ispitanici su se o delovanju i upotrebi lekovitih biljaka/biljnih proizvoda uglavnom
informisali od farmaceuta u apotekama (45,1%) i putem medija (24,2%). Oko trećine
ispitanika (37,3%) je navelo da zna razliku između biljnih lekovitih proizvoda i dijetetskih
suplemenata. Da su biljni lekoviti proizvodi efikasni, ali manje od sintetskih lekova, smatralo
je 52,9% ispitanika, dok je 61,5% smatralo da su oni bezbedni za upotrebu, ali sa mogućim
neželjenim efektima. Trećina anketiranih (32,9%) imala je poteškoće da razume uputstva za
upotrebu biljnih proizvoda, te su im bila potrebna dodatna objašnjenja. Najveći deo
ispitanika (70,6%) dobijao je savet farmaceuta pri kupovini biljnog proizvoda. Farmaceuti su
zdravstveni profesionalci koji poseduju adekvatna znanja o lekovitim biljkama/biljnim
proizvodima i imaju ključnu ulogu u savetovanju pacijenata u cilju sprovođenja pravilne
primene biljnih lekovitih i drugih biljnih proizvoda.",
journal = "Arhiv za farmaciju",
title = "Awareness of patients in the city of Belgrade about herbal products, Informisanost pacijenata na teritoriji grada Beograda o biljnim proizvodima",
volume = "72",
number = "4 suplement",
pages = "S473-S474",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4424"
}
Jovanović, A., Stefanović-Vojinović, J., Kukić-Marković, J., Petrović, S., Drobac, M.,& Tadić, I.. (2022). Awareness of patients in the city of Belgrade about herbal products. in Arhiv za farmaciju, 72(4 suplement), S473-S474.
https://hdl.handle.net/21.15107/rcub_farfar_4424
Jovanović A, Stefanović-Vojinović J, Kukić-Marković J, Petrović S, Drobac M, Tadić I. Awareness of patients in the city of Belgrade about herbal products. in Arhiv za farmaciju. 2022;72(4 suplement):S473-S474.
https://hdl.handle.net/21.15107/rcub_farfar_4424 .
Jovanović, Aleksandar, Stefanović-Vojinović, Jelena, Kukić-Marković, Jelena, Petrović, Silvana, Drobac, Milica, Tadić, Ivana, "Awareness of patients in the city of Belgrade about herbal products" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S473-S474,
https://hdl.handle.net/21.15107/rcub_farfar_4424 .

Процена здравствене писмености код пацијената са дијабетес мелитусом на примарном нивоу здравствене заштите

Jovanović, Aleksandar

(2021)

TY  - CONF
AU  - Jovanović, Aleksandar
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3834
AB  - Увод: Ниска здравствена писменост (Health literacy – HL) повезана је са лошим здравственим исходима, а код дијабетеса (ДМ) здравствено писменији пацијенти боље контролишу гликемију, имају мању преваленцу компликација, боље управљaју терапијом и комуницирају са здравственим радницима.
Циљ рада: Проценити HL и домене HL пацијената на примарном нивоу здравствене заштите и испитати разлике према социодемографским карактеристикама. У субпопулацији дијабетичара проценити нивое HL применом два инструмента и испитати разлике у нивоима и доменима HL у односу на тип дијабетеса, место становања, пол и ниво образовања.
Материјал и методе: Спроведена је проспективна студија пресека од децембра 2019. до марта 2020. године у апотеци и дому здравља. Коришћени су: Општи упитник о пацијентима, Европски упитник за процену HL (HLS-EUQ12), Упитник за брзу процену HL (BRIEF-3Q – у популацији ДМ). Нивои HL према HL скору били су неадекватна, маргинална, довољна и одлична, а према DHL скору неадекватна и адекватна.
Резултати: Од 143 пацијента, 48 је било са дијабетесом, предоминантно са ДМТ2 (68,75%). Ниску HL (HL скор ≤ 32) имало је нешто више од половине испитаника (54,6%) у укупном узорку и међу ДМ ( 52,2%). Неадекватну HL (DHL скор ≤ 9) имало је 31,25% ДМ, више оних са ДМТ2. Од 4 домена HL (доступност, разумевање, процена, примена) најлошије вреднсти код ДМ су биле у домену доступности информација. Од свих 12 питања дијабетичари су најтеже перципирали способност примене информaције када одлучују како да побољшају сопствено здравље, а најлакшим су перципирали разумевање потребе за превентивним прегледима. Виши DHL и HL скор повезан је са женским полом, факултетским и последипломским образовањем, животом у већем граду и већим месечним примањима.
Закључак: Преваленца неадекватне HL код пацијената са ДМ на примарном нивоу здрваствене заштите је висока, без обзира на уочене разлике у дистрибуцији нивоа HL у зависности од инструмента за процену. Даља истраживања предиктора ниске HL код ДМ су неопоходна.
AB  - Introduction: Low health literacy (HL) is associated with poor health outcomes. More health literate diabetes mellitus (DM) patients control glycemia better, have a lower prevalence of complications, manage therapy better and communicate with healthcare professionals.
The Aim: Тo assess HL and HL domains of patients at the primary level of health care and examine the differences according to sociodemographic characteristics; to assess HL levels using two instruments in DM patients and examine differences in HL levels and domains in relation to the type of diabetes, the place of residence, gender, income and level of education.
Material and Methods: A prospective cross-sectional study was conducted from December 2019 to March 2020 at primary care using general patient questionnaire, Short Version of the European Health Literacy Survey Questionnaire (HLS-EUQ12), and BRIEF-3Q (only for DM). HL levels were calculated as inadequate, marginal, sufficient and excellent HL scores; and according to the BRIEF-3Q as adequate and inadequate DHL scores.
Results: Of the 143 patients, 48 had diabetes, predominantly DM2 (68.75%). In total, low HL (HL score ≤ 32) has more than half of the respondents (54.6%) and 52.2% among DM. However, assessed by BRIEF-3Q there were less diabetics with inadequate HL (DHL score ≤ 9) - 31.25% DM. Of the 4 HL domains (availability, understanding, processing, application), the worst values in DM were in questions for the information availability domain. The higher DHL and HL scores is related to females, university and postgraduate education, life in a bigger city, and higher monthly incomes.
Conclusion: The prevalence of inadequate HL at the primary level DM patients is high, tough we observed differences in the distribution of HL levels depending on the assessment instrument. Further research into the predictors of low HL in DM patients is necessary.
T1  - Процена здравствене писмености код пацијената са дијабетес мелитусом на примарном нивоу здравствене заштите
T1  - Assessment of health literacy in patients with diabetes mellitus at the primary level of health care
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3834
ER  - 
@conference{
author = "Jovanović, Aleksandar",
year = "2021",
abstract = "Увод: Ниска здравствена писменост (Health literacy – HL) повезана је са лошим здравственим исходима, а код дијабетеса (ДМ) здравствено писменији пацијенти боље контролишу гликемију, имају мању преваленцу компликација, боље управљaју терапијом и комуницирају са здравственим радницима.
Циљ рада: Проценити HL и домене HL пацијената на примарном нивоу здравствене заштите и испитати разлике према социодемографским карактеристикама. У субпопулацији дијабетичара проценити нивое HL применом два инструмента и испитати разлике у нивоима и доменима HL у односу на тип дијабетеса, место становања, пол и ниво образовања.
Материјал и методе: Спроведена је проспективна студија пресека од децембра 2019. до марта 2020. године у апотеци и дому здравља. Коришћени су: Општи упитник о пацијентима, Европски упитник за процену HL (HLS-EUQ12), Упитник за брзу процену HL (BRIEF-3Q – у популацији ДМ). Нивои HL према HL скору били су неадекватна, маргинална, довољна и одлична, а према DHL скору неадекватна и адекватна.
Резултати: Од 143 пацијента, 48 је било са дијабетесом, предоминантно са ДМТ2 (68,75%). Ниску HL (HL скор ≤ 32) имало је нешто више од половине испитаника (54,6%) у укупном узорку и међу ДМ ( 52,2%). Неадекватну HL (DHL скор ≤ 9) имало је 31,25% ДМ, више оних са ДМТ2. Од 4 домена HL (доступност, разумевање, процена, примена) најлошије вреднсти код ДМ су биле у домену доступности информација. Од свих 12 питања дијабетичари су најтеже перципирали способност примене информaције када одлучују како да побољшају сопствено здравље, а најлакшим су перципирали разумевање потребе за превентивним прегледима. Виши DHL и HL скор повезан је са женским полом, факултетским и последипломским образовањем, животом у већем граду и већим месечним примањима.
Закључак: Преваленца неадекватне HL код пацијената са ДМ на примарном нивоу здрваствене заштите је висока, без обзира на уочене разлике у дистрибуцији нивоа HL у зависности од инструмента за процену. Даља истраживања предиктора ниске HL код ДМ су неопоходна., Introduction: Low health literacy (HL) is associated with poor health outcomes. More health literate diabetes mellitus (DM) patients control glycemia better, have a lower prevalence of complications, manage therapy better and communicate with healthcare professionals.
The Aim: Тo assess HL and HL domains of patients at the primary level of health care and examine the differences according to sociodemographic characteristics; to assess HL levels using two instruments in DM patients and examine differences in HL levels and domains in relation to the type of diabetes, the place of residence, gender, income and level of education.
Material and Methods: A prospective cross-sectional study was conducted from December 2019 to March 2020 at primary care using general patient questionnaire, Short Version of the European Health Literacy Survey Questionnaire (HLS-EUQ12), and BRIEF-3Q (only for DM). HL levels were calculated as inadequate, marginal, sufficient and excellent HL scores; and according to the BRIEF-3Q as adequate and inadequate DHL scores.
Results: Of the 143 patients, 48 had diabetes, predominantly DM2 (68.75%). In total, low HL (HL score ≤ 32) has more than half of the respondents (54.6%) and 52.2% among DM. However, assessed by BRIEF-3Q there were less diabetics with inadequate HL (DHL score ≤ 9) - 31.25% DM. Of the 4 HL domains (availability, understanding, processing, application), the worst values in DM were in questions for the information availability domain. The higher DHL and HL scores is related to females, university and postgraduate education, life in a bigger city, and higher monthly incomes.
Conclusion: The prevalence of inadequate HL at the primary level DM patients is high, tough we observed differences in the distribution of HL levels depending on the assessment instrument. Further research into the predictors of low HL in DM patients is necessary.",
title = "Процена здравствене писмености код пацијената са дијабетес мелитусом на примарном нивоу здравствене заштите, Assessment of health literacy in patients with diabetes mellitus at the primary level of health care",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3834"
}
Jovanović, A.. (2021). Процена здравствене писмености код пацијената са дијабетес мелитусом на примарном нивоу здравствене заштите. .
https://hdl.handle.net/21.15107/rcub_farfar_3834
Jovanović A. Процена здравствене писмености код пацијената са дијабетес мелитусом на примарном нивоу здравствене заштите. 2021;.
https://hdl.handle.net/21.15107/rcub_farfar_3834 .
Jovanović, Aleksandar, "Процена здравствене писмености код пацијената са дијабетес мелитусом на примарном нивоу здравствене заштите" (2021),
https://hdl.handle.net/21.15107/rcub_farfar_3834 .

Sadržaj estragola u etarskom ulju i infuzu herbe bosiljka, Ocimum basilicum L.

Arsenijević, Jelena; Jovanović, Aleksandar; Jevtić, Stefan; Kovačević, Nada; Drobac, Milica

(Savez farmaceutskih udruženja Srbije (SFUS), 2018)

TY  - CONF
AU  - Arsenijević, Jelena
AU  - Jovanović, Aleksandar
AU  - Jevtić, Stefan
AU  - Kovačević, Nada
AU  - Drobac, Milica
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5279
AB  - Herba bosiljka se tradicionalno koristi kao karminativ, spazmolitik, blag sedativ i
laktagog. Etarsko ulje herbe bosiljka sadrži fenilpropanoid estragol, koji je kancerogen i
genotoksičan, a čija količina zavisi od hemotipa bosiljka. Količina estragola koja se
unosi putem biljnih lekovitih proizvoda, prema preporuci Evropske agencije za lekove
(EMA), ograničena je na 0,5 mg dnevno tokom 14 dana. Cilj rada bio je ispitivanje
hemijskog sastava etarskih ulja, sadržaja estragola u etarskim uljima i infuzima herbe
bosiljka, dostupne u Srbiji.
Ispitivani su komercijalni uzorci monokomponentnih čajeva i uzorci herbe
bosiljka gajenog u domaćinstvima u različitim delovima Srbije. Infuzi su pripremljeni
prelivanjem uzoraka ključalom vodom (2 g/150 ml) i ceđenjem nakon 15 min.
Izolovanje etarskog ulja iz herbe, kao i izolovanje estragola iz infuza izvršeno je
destilacijom vodenom parom u aparaturi po Klevendžeru. Analiza etarskih ulja i
destilata infuza izvršena je GC‐FID‐MS metodom. Sadržaj estragola u etarskim uljima i
infuzima određen je metodom eksternog standarda.
Sastav svih ispitivanih etarskih ulja odgovara evropskom hemotipu bosiljka,
kojeg karakteriše visok sadržaj linalola ili linalola i estragola. Sadržaj estragola u
ispitivanim etarskim uljima iznosio je 2,1‐565,4 mg/ml, a u infuzima 0,5‐11,3 μg/ml.
Primenom ispitivanih infuza prema preporuci Deutsche Arzneimittel‐Codex (DAC) (2
g/150 ml, tri puta dnevno), dnevni unos estragola iznosio bi 0,2‐5,1 mg.
Primenom infuza pojedinih uzoraka herbe bosiljka postoji mogućnost
prekoračenjа dozvoljenоg dnevnog unosa estragola. Dobijeni rezultati ukazuju na
značaj utvrđivanja sadržaja estragola u herbi bosiljka koja se koristi u obliku biljnih
lekovitih proizvoda.
AB  - Basil herb is traditionally used as carminative, spasmolytic, mild sedative and
lactagogue. Basil essential oil contains phenylpropanoide estragole, which is
carcinogenic and genotoxic, and its amount depends on Basil chemotype. The amount
of estragole administered through herbal medicinal products, according to the
recommendation of the European Medicines Agency (EMA), is limited to 0.5 mg daily
during 14 days. The aim of this work was examination of chemical composition of
essential oils, as well as determination of estragole content in essential oils and
infusions of Basil herb available in Serbia.
We have analyzed commercial samples of monocomponent Basil herbal teas and
samples of Basil herb cultivated in different parts of Serbia. Infusions were prepared by
steeping samples in boiling water (2 g/150 ml) for 15 min and subsequent filtering.
Isolation of the herb essential oil, as well as isolation of estragole from infusions was
carried out by hydrodistillation using a Clevenger‐type apparatus. Analyses of essential
oils and infusion distillates were performed using GC‐FID‐MS. The content of estragole
in essential oils and infusions was determined using external standard method.
Chemical composition of all investigated essential oils corresponds to European
chemotype of Basil that is characterized by high content of linalool or linalool and
estragole. The content of estragole in essential oils ranged from 2.1 to 565.4 mg/ml,
whereas infusions contained 0.5‐11.3 μg/ml of this compound. If the examined
infusions are administered according to the recommendation of Deutsche Arzneimittel‐
Codex (DAC) (2 g/150 ml, three times daily), the daily intake of estragole would be 0.2‐
5.1 mg.
By administration of infusions of some Basil herb samples, there is a possibility
of exceeding the permitted daily intake of estragole. The obtained results indicate the
importance of determining the content of estragole in Basil herb used in the form of
herbal medicinal products.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Sadržaj estragola u etarskom ulju i infuzu herbe bosiljka, Ocimum basilicum L.
T1  - The content of estragole in essential oil and infusion of basil herb, Ocimum basilicum L.
VL  - 68
IS  - 3
SP  - 712
EP  - 713
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5279
ER  - 
@conference{
author = "Arsenijević, Jelena and Jovanović, Aleksandar and Jevtić, Stefan and Kovačević, Nada and Drobac, Milica",
year = "2018",
abstract = "Herba bosiljka se tradicionalno koristi kao karminativ, spazmolitik, blag sedativ i
laktagog. Etarsko ulje herbe bosiljka sadrži fenilpropanoid estragol, koji je kancerogen i
genotoksičan, a čija količina zavisi od hemotipa bosiljka. Količina estragola koja se
unosi putem biljnih lekovitih proizvoda, prema preporuci Evropske agencije za lekove
(EMA), ograničena je na 0,5 mg dnevno tokom 14 dana. Cilj rada bio je ispitivanje
hemijskog sastava etarskih ulja, sadržaja estragola u etarskim uljima i infuzima herbe
bosiljka, dostupne u Srbiji.
Ispitivani su komercijalni uzorci monokomponentnih čajeva i uzorci herbe
bosiljka gajenog u domaćinstvima u različitim delovima Srbije. Infuzi su pripremljeni
prelivanjem uzoraka ključalom vodom (2 g/150 ml) i ceđenjem nakon 15 min.
Izolovanje etarskog ulja iz herbe, kao i izolovanje estragola iz infuza izvršeno je
destilacijom vodenom parom u aparaturi po Klevendžeru. Analiza etarskih ulja i
destilata infuza izvršena je GC‐FID‐MS metodom. Sadržaj estragola u etarskim uljima i
infuzima određen je metodom eksternog standarda.
Sastav svih ispitivanih etarskih ulja odgovara evropskom hemotipu bosiljka,
kojeg karakteriše visok sadržaj linalola ili linalola i estragola. Sadržaj estragola u
ispitivanim etarskim uljima iznosio je 2,1‐565,4 mg/ml, a u infuzima 0,5‐11,3 μg/ml.
Primenom ispitivanih infuza prema preporuci Deutsche Arzneimittel‐Codex (DAC) (2
g/150 ml, tri puta dnevno), dnevni unos estragola iznosio bi 0,2‐5,1 mg.
Primenom infuza pojedinih uzoraka herbe bosiljka postoji mogućnost
prekoračenjа dozvoljenоg dnevnog unosa estragola. Dobijeni rezultati ukazuju na
značaj utvrđivanja sadržaja estragola u herbi bosiljka koja se koristi u obliku biljnih
lekovitih proizvoda., Basil herb is traditionally used as carminative, spasmolytic, mild sedative and
lactagogue. Basil essential oil contains phenylpropanoide estragole, which is
carcinogenic and genotoxic, and its amount depends on Basil chemotype. The amount
of estragole administered through herbal medicinal products, according to the
recommendation of the European Medicines Agency (EMA), is limited to 0.5 mg daily
during 14 days. The aim of this work was examination of chemical composition of
essential oils, as well as determination of estragole content in essential oils and
infusions of Basil herb available in Serbia.
We have analyzed commercial samples of monocomponent Basil herbal teas and
samples of Basil herb cultivated in different parts of Serbia. Infusions were prepared by
steeping samples in boiling water (2 g/150 ml) for 15 min and subsequent filtering.
Isolation of the herb essential oil, as well as isolation of estragole from infusions was
carried out by hydrodistillation using a Clevenger‐type apparatus. Analyses of essential
oils and infusion distillates were performed using GC‐FID‐MS. The content of estragole
in essential oils and infusions was determined using external standard method.
Chemical composition of all investigated essential oils corresponds to European
chemotype of Basil that is characterized by high content of linalool or linalool and
estragole. The content of estragole in essential oils ranged from 2.1 to 565.4 mg/ml,
whereas infusions contained 0.5‐11.3 μg/ml of this compound. If the examined
infusions are administered according to the recommendation of Deutsche Arzneimittel‐
Codex (DAC) (2 g/150 ml, three times daily), the daily intake of estragole would be 0.2‐
5.1 mg.
By administration of infusions of some Basil herb samples, there is a possibility
of exceeding the permitted daily intake of estragole. The obtained results indicate the
importance of determining the content of estragole in Basil herb used in the form of
herbal medicinal products.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Sadržaj estragola u etarskom ulju i infuzu herbe bosiljka, Ocimum basilicum L., The content of estragole in essential oil and infusion of basil herb, Ocimum basilicum L.",
volume = "68",
number = "3",
pages = "712-713",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5279"
}
Arsenijević, J., Jovanović, A., Jevtić, S., Kovačević, N.,& Drobac, M.. (2018). Sadržaj estragola u etarskom ulju i infuzu herbe bosiljka, Ocimum basilicum L.. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 68(3), 712-713.
https://hdl.handle.net/21.15107/rcub_farfar_5279
Arsenijević J, Jovanović A, Jevtić S, Kovačević N, Drobac M. Sadržaj estragola u etarskom ulju i infuzu herbe bosiljka, Ocimum basilicum L.. in Arhiv za farmaciju. 2018;68(3):712-713.
https://hdl.handle.net/21.15107/rcub_farfar_5279 .
Arsenijević, Jelena, Jovanović, Aleksandar, Jevtić, Stefan, Kovačević, Nada, Drobac, Milica, "Sadržaj estragola u etarskom ulju i infuzu herbe bosiljka, Ocimum basilicum L." in Arhiv za farmaciju, 68, no. 3 (2018):712-713,
https://hdl.handle.net/21.15107/rcub_farfar_5279 .