TY  - JOUR
AU  - Mravik, Željko
AU  - Bajuk-Bogdanović, Danica
AU  - Jovanović, Sonja
AU  - Rmuš, Jelena
AU  - Olejniczak, Andrzej
AU  - Mraković, Ana
AU  - Lazarević, Jasmina
AU  - Uskoković-Marković, Snežana
AU  - Lazarević, Nenad
AU  - Skuratov, Vladimir
AU  - Jovanović, Zoran
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4246
AB  - Ion beam irradiation is a versatile tool for structural modification andengineering of new materials. In this study, 12-tungstophosphoric acid (WPA)films of different thickness were spin-coated on platinized silicon substrate andirradiated with low energy hydrogen ions (10 keV) and swift heavy ions (Bi,Xe, and V) with energies up to 710 MeV. The different energy/fluence combi-nations allowed controllable structural changes that were investigated in detailusing Raman and Infrared spectroscopy. For 120-nm-thick WPA samples, theirradiation led to the decrease of intensity of the skeletal and W-Oc-W bands ofKeggin anion in order: Bi < V < Xe (for their applied energy/fluence combina-tion). Also, symmetry change of Keggin anion similar to the one observed inthe case of Keggin anions interacting with the supports was observed. For theselected ion beam irradiation parameters, xenon ion beam induced transforma-tion of WPA to polytungstate. For 20-μm-thick WPA samples, the irradiationwith hydrogen ion beam induced changes of skeletal vibrations and increasedindividualistic behavior of Keggin anions. As the fluence increased, theamount of the Keggin anions partially transformed to bronze also increased.Irradiation with vanadium also caused transformation to bronze-like structurebut with higher ratio of terminal W=Odbonds. The overall results show clearReceived: 9 February 2022Revised: 17 June 2022Accepted: 5 July 2022DOI: 10.1002/jrs.6423J Raman Spectrosc.2022;1–11.wileyonlinelibrary.com/journal/jrs© 2022 John Wiley & Sons Ltd.1correlation between degree of structural modification of WPA and thecalculated displacement per atom value. These results open possibilities forengineering new catalytically active structures of polyoxometalates with thehelp of ion beams.
PB  - John Wiley and Sons Ltd
T2  - Journal of Raman Spectroscopy
T1  - Modification of Keggin anion structure with ion beams—A new spectroscopic insights into the effects of keV- and MeV-ion beam irradiation on 12-tungstophosphoric acid
VL  - 53
IS  - 11
SP  - 1974
SP  - 8167
EP  - 1984
DO  - 10.1002/jrs.6423
ER  - 

@article{
author = "Mravik, Željko and Bajuk-Bogdanović, Danica and Jovanović, Sonja and Rmuš, Jelena and Olejniczak, Andrzej and Mraković, Ana and Lazarević, Jasmina and Uskoković-Marković, Snežana and Lazarević, Nenad and Skuratov, Vladimir and Jovanović, Zoran",
year = "2022",
abstract = "Ion beam irradiation is a versatile tool for structural modification andengineering of new materials. In this study, 12-tungstophosphoric acid (WPA)films of different thickness were spin-coated on platinized silicon substrate andirradiated with low energy hydrogen ions (10 keV) and swift heavy ions (Bi,Xe, and V) with energies up to 710 MeV. The different energy/fluence combi-nations allowed controllable structural changes that were investigated in detailusing Raman and Infrared spectroscopy. For 120-nm-thick WPA samples, theirradiation led to the decrease of intensity of the skeletal and W-Oc-W bands ofKeggin anion in order: Bi < V < Xe (for their applied energy/fluence combina-tion). Also, symmetry change of Keggin anion similar to the one observed inthe case of Keggin anions interacting with the supports was observed. For theselected ion beam irradiation parameters, xenon ion beam induced transforma-tion of WPA to polytungstate. For 20-μm-thick WPA samples, the irradiationwith hydrogen ion beam induced changes of skeletal vibrations and increasedindividualistic behavior of Keggin anions. As the fluence increased, theamount of the Keggin anions partially transformed to bronze also increased.Irradiation with vanadium also caused transformation to bronze-like structurebut with higher ratio of terminal W=Odbonds. The overall results show clearReceived: 9 February 2022Revised: 17 June 2022Accepted: 5 July 2022DOI: 10.1002/jrs.6423J Raman Spectrosc.2022;1–11.wileyonlinelibrary.com/journal/jrs© 2022 John Wiley & Sons Ltd.1correlation between degree of structural modification of WPA and thecalculated displacement per atom value. These results open possibilities forengineering new catalytically active structures of polyoxometalates with thehelp of ion beams.",
publisher = "John Wiley and Sons Ltd",
journal = "Journal of Raman Spectroscopy",
title = "Modification of Keggin anion structure with ion beams—A new spectroscopic insights into the effects of keV- and MeV-ion beam irradiation on 12-tungstophosphoric acid",
volume = "53",
number = "11",
pages = "1974-8167-1984",
doi = "10.1002/jrs.6423"
}

Mravik, Ž., Bajuk-Bogdanović, D., Jovanović, S., Rmuš, J., Olejniczak, A., Mraković, A., Lazarević, J., Uskoković-Marković, S., Lazarević, N., Skuratov, V.,& Jovanović, Z.. (2022). Modification of Keggin anion structure with ion beams—A new spectroscopic insights into the effects of keV- and MeV-ion beam irradiation on 12-tungstophosphoric acid. in Journal of Raman Spectroscopy
John Wiley and Sons Ltd., 53(11), 1974-1984.
https://doi.org/10.1002/jrs.6423

Mravik Ž, Bajuk-Bogdanović D, Jovanović S, Rmuš J, Olejniczak A, Mraković A, Lazarević J, Uskoković-Marković S, Lazarević N, Skuratov V, Jovanović Z. Modification of Keggin anion structure with ion beams—A new spectroscopic insights into the effects of keV- and MeV-ion beam irradiation on 12-tungstophosphoric acid. in Journal of Raman Spectroscopy. 2022;53(11):1974-1984.
doi:10.1002/jrs.6423 .

Mravik, Željko, Bajuk-Bogdanović, Danica, Jovanović, Sonja, Rmuš, Jelena, Olejniczak, Andrzej, Mraković, Ana, Lazarević, Jasmina, Uskoković-Marković, Snežana, Lazarević, Nenad, Skuratov, Vladimir, Jovanović, Zoran, "Modification of Keggin anion structure with ion beams—A new spectroscopic insights into the effects of keV- and MeV-ion beam irradiation on 12-tungstophosphoric acid" in Journal of Raman Spectroscopy, 53, no. 11 (2022):1974-1984,
https://doi.org/10.1002/jrs.6423 . .

TY  - JOUR
AU  - Krstić, Marko
AU  - Đuriš, Jelena
AU  - Petrović, Ognjen
AU  - Lazarević, Nenad
AU  - Cvijić, Sandra
AU  - Ibrić, Svetlana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2995
AB  - The aim was to develop immediate-release carbamazepine lipid matrix tablets by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental design. In the second set of experiments, amounts of meltable binder and Cremophor (R) RH40 were varied according to the central composite design. The optimal formulation which showed the fastest release rate (more than 80% in first 30 min) was identified (compression force of 8 kN, 20% of Labrafil (R) 2130CS, 10% of Cremophor (R) RH40, 30% of carbamazepine, 5% of crospovidone NP and Neusilin (R) UFL2 used as the carrier). Different analytical techniques (DSC, PXRD, FT-IR, Raman spectroscopy) confirmed the maintenance of carbamazepine in its therapeutically active polymorph form III in the optimal formulation. Raman spectroscopy was used to demonstrate the stability of the optimal formulation during the two months stability study (25 degrees C, RH 40%). It can be concluded that melt granulation technique can be used in development of lipid matrix tablets with immediate-release of the drug.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Drug Delivery Science and Technology
T1  - Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine
VL  - 39
SP  - 467
EP  - 474
DO  - 10.1016/j.jddst.2017.04.024
ER  - 

@article{
author = "Krstić, Marko and Đuriš, Jelena and Petrović, Ognjen and Lazarević, Nenad and Cvijić, Sandra and Ibrić, Svetlana",
year = "2017",
abstract = "The aim was to develop immediate-release carbamazepine lipid matrix tablets by using the melt granulation technique, application of Quality by design. The first set of screening experiments investigated the influence of six parameters (meltable binder type; amounts of meltable binder, carbamazepine and crospovidone; carrier type, and compression force) on carbamazepine release rate from tablets, using fractional factorial experimental design. In the second set of experiments, amounts of meltable binder and Cremophor (R) RH40 were varied according to the central composite design. The optimal formulation which showed the fastest release rate (more than 80% in first 30 min) was identified (compression force of 8 kN, 20% of Labrafil (R) 2130CS, 10% of Cremophor (R) RH40, 30% of carbamazepine, 5% of crospovidone NP and Neusilin (R) UFL2 used as the carrier). Different analytical techniques (DSC, PXRD, FT-IR, Raman spectroscopy) confirmed the maintenance of carbamazepine in its therapeutically active polymorph form III in the optimal formulation. Raman spectroscopy was used to demonstrate the stability of the optimal formulation during the two months stability study (25 degrees C, RH 40%). It can be concluded that melt granulation technique can be used in development of lipid matrix tablets with immediate-release of the drug.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Drug Delivery Science and Technology",
title = "Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine",
volume = "39",
pages = "467-474",
doi = "10.1016/j.jddst.2017.04.024"
}

Krstić, M., Đuriš, J., Petrović, O., Lazarević, N., Cvijić, S.,& Ibrić, S.. (2017). Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine. in Journal of Drug Delivery Science and Technology
Elsevier Science BV, Amsterdam., 39, 467-474.
https://doi.org/10.1016/j.jddst.2017.04.024

Krstić M, Đuriš J, Petrović O, Lazarević N, Cvijić S, Ibrić S. Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine. in Journal of Drug Delivery Science and Technology. 2017;39:467-474.
doi:10.1016/j.jddst.2017.04.024 .

Krstić, Marko, Đuriš, Jelena, Petrović, Ognjen, Lazarević, Nenad, Cvijić, Sandra, Ibrić, Svetlana, "Application of the melt granulation technique in development of lipid matrix tablets with immediate release of carbamazepine" in Journal of Drug Delivery Science and Technology, 39 (2017):467-474,
https://doi.org/10.1016/j.jddst.2017.04.024 . .