TY  - CONF
AU  - Đuričić, Ivana
AU  - Šobajić, Slađana
AU  - Perunicić, G.
AU  - Miletić, Ivanka
AU  - Ruzić, P.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/934
PB  - Karger, Basel
C3  - Annals of Nutrition and Metabolism
T1  - Omega-3 fatty acid and plasma lipid profiles in patients on haemodialysis treatment
VL  - 51
IS  - Suppl. 1
SP  - 275
EP  - 275
DO  - 10.1159/000105121
ER  - 

@conference{
author = "Đuričić, Ivana and Šobajić, Slađana and Perunicić, G. and Miletić, Ivanka and Ruzić, P.",
year = "2007",
publisher = "Karger, Basel",
journal = "Annals of Nutrition and Metabolism",
title = "Omega-3 fatty acid and plasma lipid profiles in patients on haemodialysis treatment",
volume = "51",
number = "Suppl. 1",
pages = "275-275",
doi = "10.1159/000105121"
}

Đuričić, I., Šobajić, S., Perunicić, G., Miletić, I.,& Ruzić, P.. (2007). Omega-3 fatty acid and plasma lipid profiles in patients on haemodialysis treatment. in Annals of Nutrition and Metabolism
Karger, Basel., 51(Suppl. 1), 275-275.
https://doi.org/10.1159/000105121

Đuričić I, Šobajić S, Perunicić G, Miletić I, Ruzić P. Omega-3 fatty acid and plasma lipid profiles in patients on haemodialysis treatment. in Annals of Nutrition and Metabolism. 2007;51(Suppl. 1):275-275.
doi:10.1159/000105121 .

Đuričić, Ivana, Šobajić, Slađana, Perunicić, G., Miletić, Ivanka, Ruzić, P., "Omega-3 fatty acid and plasma lipid profiles in patients on haemodialysis treatment" in Annals of Nutrition and Metabolism, 51, no. Suppl. 1 (2007):275-275,
https://doi.org/10.1159/000105121 . .

TY  - JOUR
AU  - Rasić-Milutinović, Z.
AU  - Perunicić, G.
AU  - Plješa, Steva
AU  - Gluvić, Z.
AU  - Šobajić, Slađana
AU  - Đurić, I.
AU  - Ristić, D.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/935
AB  - Aims/Hypothesis. It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Methods. This study explored the ratio between red blood cells (RBC) phospholipid long chain fatty acids (LC FAs) and components of metabolic syndrome (MeS) in 35 patients (mean age 54.50 +/- 11.99 years) with CRF on MHD. Furthermore, the effects of omega-3 FA eight-week's supplementation (EPA+DHA, 2.4g/d) on the MeS features and inflammatory markers TNF-alpha, IL 6, and hsCRP were examined. Results. Supplementation increased EPA and DHA levels in RBCs (p = 0.009 for EPA and p = 0.002 for DHA). Total n-6 PUFAs: n-3 PUFAs ratio tended to be lower after supplementation (p = 0.31), but not significantly. Data revealed a significant decrease of saturated FAs (SFA) (P = 0.01) as well as total SFA: n-3 PUFAs ratio during the treatment (P = 0.04). The values of serum insulin and calculated IR index-IR HOMA were reduced after supplementation (p = 0.001 for both). There was a significant decrease in the levels of all inflammatory markers (p = 0.01 for TNF alpha, p = 0.001 for IL 6, p = 0.001 for hsCRP, and p = 0.01 for ferritin). In multivariate regression analysis, only the changes in n-6 PUFAs: n-3 PUFAs ratio independently contributed to 40% of the variance in IR HOMA. The impact of changes in PUFAs level in RBCs membrane phospholipid fatty acids on inflammation markers was also registered. The changes in n-6: n-3 PUFAs ratio independently contributed to 19% of the variance in TNF alpha. Conclusion. It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. The anti-inflammatory effects of the supplemented PUFAs were also presented.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Reproductive Toxicology
T1  - Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients
VL  - 29
IS  - 3
SP  - 321
EP  - 329
DO  - 10.1080/08860220601184092
ER  - 

@article{
author = "Rasić-Milutinović, Z. and Perunicić, G. and Plješa, Steva and Gluvić, Z. and Šobajić, Slađana and Đurić, I. and Ristić, D.",
year = "2007",
abstract = "Aims/Hypothesis. It was suggested that polyunsaturated n-3 fatty acids (n-3 PUFAs) could improve insulin sensitivity and have an anti-inflammatory effects in overall population. This study investigates a possible effect of n-3 PUFAs supplementation on the insulin sensitivity and some inflammatory markers; hence, patients with chronic renal failure (CRF) on maintenance hemodialysis (MHD) are presented with insulin resistance. Methods. This study explored the ratio between red blood cells (RBC) phospholipid long chain fatty acids (LC FAs) and components of metabolic syndrome (MeS) in 35 patients (mean age 54.50 +/- 11.99 years) with CRF on MHD. Furthermore, the effects of omega-3 FA eight-week's supplementation (EPA+DHA, 2.4g/d) on the MeS features and inflammatory markers TNF-alpha, IL 6, and hsCRP were examined. Results. Supplementation increased EPA and DHA levels in RBCs (p = 0.009 for EPA and p = 0.002 for DHA). Total n-6 PUFAs: n-3 PUFAs ratio tended to be lower after supplementation (p = 0.31), but not significantly. Data revealed a significant decrease of saturated FAs (SFA) (P = 0.01) as well as total SFA: n-3 PUFAs ratio during the treatment (P = 0.04). The values of serum insulin and calculated IR index-IR HOMA were reduced after supplementation (p = 0.001 for both). There was a significant decrease in the levels of all inflammatory markers (p = 0.01 for TNF alpha, p = 0.001 for IL 6, p = 0.001 for hsCRP, and p = 0.01 for ferritin). In multivariate regression analysis, only the changes in n-6 PUFAs: n-3 PUFAs ratio independently contributed to 40% of the variance in IR HOMA. The impact of changes in PUFAs level in RBCs membrane phospholipid fatty acids on inflammation markers was also registered. The changes in n-6: n-3 PUFAs ratio independently contributed to 19% of the variance in TNF alpha. Conclusion. It was concluded that the EPA and DHA moderate dose administration in the patients with CRF on MHD had a beneficial effect on insulin resistance decrease. The anti-inflammatory effects of the supplemented PUFAs were also presented.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Reproductive Toxicology",
title = "Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients",
volume = "29",
number = "3",
pages = "321-329",
doi = "10.1080/08860220601184092"
}

Rasić-Milutinović, Z., Perunicić, G., Plješa, S., Gluvić, Z., Šobajić, S., Đurić, I.,& Ristić, D.. (2007). Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients. in Reproductive Toxicology
Taylor & Francis Ltd, Abingdon., 29(3), 321-329.
https://doi.org/10.1080/08860220601184092

Rasić-Milutinović Z, Perunicić G, Plješa S, Gluvić Z, Šobajić S, Đurić I, Ristić D. Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients. in Reproductive Toxicology. 2007;29(3):321-329.
doi:10.1080/08860220601184092 .

Rasić-Milutinović, Z., Perunicić, G., Plješa, Steva, Gluvić, Z., Šobajić, Slađana, Đurić, I., Ristić, D., "Effects of N-3PUFAs supplementation on insulin resistance and inflammatory biomarkers in hemodialysis patients" in Reproductive Toxicology, 29, no. 3 (2007):321-329,
https://doi.org/10.1080/08860220601184092 . .