TY  - JOUR
AU  - Theochari, Ioanna
AU  - Mitsou, E.
AU  - Nikolić, Ines
AU  - Ilić, Tanja
AU  - Dobričić, Vladimir
AU  - Pletsa, V.
AU  - Savić, Snežana
AU  - Xenakis, Aristotelis
AU  - Papadimitriou, Vassiliki
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3821
AB  - Colloidal liquid-in-liquid nanodispersions such as micro- and nanoemulsions were developed, characterized and compared as potential carriers for the topical administration of ibuprofen. Both colloidal systems were based on water as the continuous phase, limonene as the dispersed phase and a mixture of pharmaceutically acceptable surfactants (Pluronic® L-35, Labrasol®, Tween 80). To improve their properties regarding penetration efficacy, an aqueous solution of chitosan was used as continuous phase in both systems. Micro- and nanoemulsions were structurally studied applying Dynamic Light Scattering (DLS), Electron Paramagnetic Resonance (EPR) spectroscopy and viscometry. Microemulsions with mean droplet diameter of 41 nm and PdI < 0.3 were obtained in the absence and presence of either chitosan or ibuprofen. Nanoemulsions were developed by high-pressure homogenization using the same ingredients at different concentrations. Unlike thermodynamically stable microemulsions, nanoemulsions showed storage stability for 2 months, higher droplet size (174 nm) and lower PdI (<0.15). In the presence of Ibuprofen droplet size and stability of the nanoemulsions were not affected. EPR spectroscopy revealed ibuprofen’s location in the oil cores and gave information about the rigidity of the surfactants’ monolayer. In both cases an outer compact configuration of the interfacial layer and a more flexible inner one was observed. The cytotoxicity of both systems towards human melanoma cell line WM 164 was relatively low. Interestingly, ibuprofen was released more promptly from the microemulsions (prospectively, systemic exposure increase), however the ex vivo studies, regarding skin uptake and penetration, revealed that the nanoemulsions are more appropriate as nanocarriers for the topical administration of ibuprofen.
PB  - Elsevier B.V.
T2  - Journal of Molecular Liquids
T1  - Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and bioperformances
VL  - 334
DO  - 10.1016/j.molliq.2021.116021
ER  - 

@article{
author = "Theochari, Ioanna and Mitsou, E. and Nikolić, Ines and Ilić, Tanja and Dobričić, Vladimir and Pletsa, V. and Savić, Snežana and Xenakis, Aristotelis and Papadimitriou, Vassiliki",
year = "2021",
abstract = "Colloidal liquid-in-liquid nanodispersions such as micro- and nanoemulsions were developed, characterized and compared as potential carriers for the topical administration of ibuprofen. Both colloidal systems were based on water as the continuous phase, limonene as the dispersed phase and a mixture of pharmaceutically acceptable surfactants (Pluronic® L-35, Labrasol®, Tween 80). To improve their properties regarding penetration efficacy, an aqueous solution of chitosan was used as continuous phase in both systems. Micro- and nanoemulsions were structurally studied applying Dynamic Light Scattering (DLS), Electron Paramagnetic Resonance (EPR) spectroscopy and viscometry. Microemulsions with mean droplet diameter of 41 nm and PdI < 0.3 were obtained in the absence and presence of either chitosan or ibuprofen. Nanoemulsions were developed by high-pressure homogenization using the same ingredients at different concentrations. Unlike thermodynamically stable microemulsions, nanoemulsions showed storage stability for 2 months, higher droplet size (174 nm) and lower PdI (<0.15). In the presence of Ibuprofen droplet size and stability of the nanoemulsions were not affected. EPR spectroscopy revealed ibuprofen’s location in the oil cores and gave information about the rigidity of the surfactants’ monolayer. In both cases an outer compact configuration of the interfacial layer and a more flexible inner one was observed. The cytotoxicity of both systems towards human melanoma cell line WM 164 was relatively low. Interestingly, ibuprofen was released more promptly from the microemulsions (prospectively, systemic exposure increase), however the ex vivo studies, regarding skin uptake and penetration, revealed that the nanoemulsions are more appropriate as nanocarriers for the topical administration of ibuprofen.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Liquids",
title = "Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and bioperformances",
volume = "334",
doi = "10.1016/j.molliq.2021.116021"
}

Theochari, I., Mitsou, E., Nikolić, I., Ilić, T., Dobričić, V., Pletsa, V., Savić, S., Xenakis, A.,& Papadimitriou, V.. (2021). Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and bioperformances. in Journal of Molecular Liquids
Elsevier B.V.., 334.
https://doi.org/10.1016/j.molliq.2021.116021

Theochari I, Mitsou E, Nikolić I, Ilić T, Dobričić V, Pletsa V, Savić S, Xenakis A, Papadimitriou V. Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and bioperformances. in Journal of Molecular Liquids. 2021;334.
doi:10.1016/j.molliq.2021.116021 .

Theochari, Ioanna, Mitsou, E., Nikolić, Ines, Ilić, Tanja, Dobričić, Vladimir, Pletsa, V., Savić, Snežana, Xenakis, Aristotelis, Papadimitriou, Vassiliki, "Colloidal nanodispersions for the topical delivery of Ibuprofen: Structure, dynamics and bioperformances" in Journal of Molecular Liquids, 334 (2021),
https://doi.org/10.1016/j.molliq.2021.116021 . .