TY  - JOUR
AU  - Krmar, Jovana
AU  - Svrkota, Bojana
AU  - Obradović, Darija
AU  - Vlatković, Vladimir
AU  - Lazović, Saša
AU  - Otašević, Biljana
PY  - 2024
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5634
AB  - Initially employed primarily at a preparative scale for enantiomer separation of chiral drug
candidates, Supercritical Fluid Chromatography (SFC) is nowadays extensively used in the
analytical mode. Recent advances in SFC separation science have emphasized its potential for
modern and environmentally friendly pharmaceutical analysis.
The aim of this review is to provide a deeper insight into the main fundamental and practical
aspects of the SFC technique in order to familiarize readers with its versatile nature and efficiency
in creating sustainable chromatographic solutions. All considerations are made primarily in the
context of the most widely used mode of operation - achiral SFC. In addition, recent applications
of this promising technique are presented at the end of the article to further promote its use in
pharmaceutical analytical practice.
AB  - Na početku pretežno korišćena kao preparativna tehnika u enantioseparaciji hiralnih
molekula kandidatâ za lek, superkritična fluidna hromatografija (eng. supercritical fluid
chromatography, SFC) danas se široko koristi u analitičke svrhe. Noviji naučni napori ukazali su
na značaj SFC tehnike u modernoj i ekološki prihvatljivoj farmaceutskoj analizi.
Cilj ovog preglednog rada je pružanje dubljeg uvida u najvažnije fundamentalne i praktične
aspekte SFC tehnike, kako bi se čitaocima približio njen svestrani karakter, te efikasnost u
kreiranju održivih hromatografskih rešenja. Sva razmatranja prevashodno su data u kontekstu
najzastupljenijeg režima rada - ahiralne SFC. Takođe, na kraju rada predstavljene su savremene
primene ove obećavajuće tehnike kako bi se dodatno ohrabrilo njeno usvajanje u farmaceutsku
analitičku praksu.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
PB  - Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Arhiv za farmaciju
T1  - Leveraging the Power of Supercritical Fluid Chromatography for Eco-Conscious Solutions in Pharmaceutical Analysis
T1  - Efikasnost superkritične fluidne hromatografije u kreiranju ekološki prihvatljivih rešenja u farmaceutskoj analizi
VL  - 74
IS  - 2
SP  - 133
EP  - 159
DO  - 10.5937/arhfarm74-49565
ER  - 

@article{
author = "Krmar, Jovana and Svrkota, Bojana and Obradović, Darija and Vlatković, Vladimir and Lazović, Saša and Otašević, Biljana",
year = "2024",
abstract = "Initially employed primarily at a preparative scale for enantiomer separation of chiral drug
candidates, Supercritical Fluid Chromatography (SFC) is nowadays extensively used in the
analytical mode. Recent advances in SFC separation science have emphasized its potential for
modern and environmentally friendly pharmaceutical analysis.
The aim of this review is to provide a deeper insight into the main fundamental and practical
aspects of the SFC technique in order to familiarize readers with its versatile nature and efficiency
in creating sustainable chromatographic solutions. All considerations are made primarily in the
context of the most widely used mode of operation - achiral SFC. In addition, recent applications
of this promising technique are presented at the end of the article to further promote its use in
pharmaceutical analytical practice., Na početku pretežno korišćena kao preparativna tehnika u enantioseparaciji hiralnih
molekula kandidatâ za lek, superkritična fluidna hromatografija (eng. supercritical fluid
chromatography, SFC) danas se široko koristi u analitičke svrhe. Noviji naučni napori ukazali su
na značaj SFC tehnike u modernoj i ekološki prihvatljivoj farmaceutskoj analizi.
Cilj ovog preglednog rada je pružanje dubljeg uvida u najvažnije fundamentalne i praktične
aspekte SFC tehnike, kako bi se čitaocima približio njen svestrani karakter, te efikasnost u
kreiranju održivih hromatografskih rešenja. Sva razmatranja prevashodno su data u kontekstu
najzastupljenijeg režima rada - ahiralne SFC. Takođe, na kraju rada predstavljene su savremene
primene ove obećavajuće tehnike kako bi se dodatno ohrabrilo njeno usvajanje u farmaceutsku
analitičku praksu.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd, Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Arhiv za farmaciju",
title = "Leveraging the Power of Supercritical Fluid Chromatography for Eco-Conscious Solutions in Pharmaceutical Analysis, Efikasnost superkritične fluidne hromatografije u kreiranju ekološki prihvatljivih rešenja u farmaceutskoj analizi",
volume = "74",
number = "2",
pages = "133-159",
doi = "10.5937/arhfarm74-49565"
}

Krmar, J., Svrkota, B., Obradović, D., Vlatković, V., Lazović, S.,& Otašević, B.. (2024). Leveraging the Power of Supercritical Fluid Chromatography for Eco-Conscious Solutions in Pharmaceutical Analysis. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 74(2), 133-159.
https://doi.org/10.5937/arhfarm74-49565

Krmar J, Svrkota B, Obradović D, Vlatković V, Lazović S, Otašević B. Leveraging the Power of Supercritical Fluid Chromatography for Eco-Conscious Solutions in Pharmaceutical Analysis. in Arhiv za farmaciju. 2024;74(2):133-159.
doi:10.5937/arhfarm74-49565 .

Krmar, Jovana, Svrkota, Bojana, Obradović, Darija, Vlatković, Vladimir, Lazović, Saša, Otašević, Biljana, "Leveraging the Power of Supercritical Fluid Chromatography for Eco-Conscious Solutions in Pharmaceutical Analysis" in Arhiv za farmaciju, 74, no. 2 (2024):133-159,
https://doi.org/10.5937/arhfarm74-49565 . .