TY  - JOUR
AU  - Petrović, Stanislava
AU  - Bogavac-Stanojević, Nataša
AU  - Lakić, Dragana
AU  - Peco-Antić, Amira
AU  - Vulicević, Irena
AU  - Ivanišević, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2467
AB  - Introduction: Acute kidney injury (AKI) is significant problem in children with congenital heart disease (CHD) who undergo cardiac surgery. The economic impact of a biomarker-based diagnostic strategy for AKI in pediatric populations undergoing CHD surgery is unknown. The aim of this study was to perform the cost effectiveness analysis of using serum cystatin C (sCysC), urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine liver fatty acid-binding protein (uL-FABP) for the diagnosis of AKI in children after cardiac surgery compared with current diagnostic method (monitoring of serum creatinine (sCr) level). Materials and methods: We developed a decision analytical model to estimate incremental cost-effectiveness of different biomarker-based diagnostic strategies compared to current diagnostic strategy. The Markov model was created to compare the lifetime cost associated with using of sCysC, uNGAL, uL-FABP with monitoring of sCr level for the diagnosis of AKI. The utility measurement included in the analysis was quality-adjusted life years (QALY). The results of the analysis are presented as the incremental cost-effectiveness ratio (ICER). Results: Analysed biomarker-based diagnostic strategies for AKI were cost-effective compared to current diagnostic method. However, uNGAL and sCys C strategies yielded higher costs and lower effectiveness compared to uL-FABP strategy. uL-FABP added 1.43 QALY compared to current diagnostic method at an additional cost of $8521.87 per patient. Therefore, ICER for uL-FABP compared to sCr was $5959.35/QALY. Conclusions: Our results suggest that the use of uL-FABP would represent cost effective strategy for early diagnosis of AKI in children after cardiac surgery.
PB  - Croatian Soc Medical Biochemists, Zagreb
T2  - Biochemia Medica
T1  - Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery
VL  - 25
IS  - 2
SP  - 262
EP  - 271
DO  - 10.11613/BM.2015.027
ER  - 

@article{
author = "Petrović, Stanislava and Bogavac-Stanojević, Nataša and Lakić, Dragana and Peco-Antić, Amira and Vulicević, Irena and Ivanišević, Ivana and Kotur-Stevuljević, Jelena and Jelić-Ivanović, Zorana",
year = "2015",
abstract = "Introduction: Acute kidney injury (AKI) is significant problem in children with congenital heart disease (CHD) who undergo cardiac surgery. The economic impact of a biomarker-based diagnostic strategy for AKI in pediatric populations undergoing CHD surgery is unknown. The aim of this study was to perform the cost effectiveness analysis of using serum cystatin C (sCysC), urine neutrophil gelatinase-associated lipocalin (uNGAL) and urine liver fatty acid-binding protein (uL-FABP) for the diagnosis of AKI in children after cardiac surgery compared with current diagnostic method (monitoring of serum creatinine (sCr) level). Materials and methods: We developed a decision analytical model to estimate incremental cost-effectiveness of different biomarker-based diagnostic strategies compared to current diagnostic strategy. The Markov model was created to compare the lifetime cost associated with using of sCysC, uNGAL, uL-FABP with monitoring of sCr level for the diagnosis of AKI. The utility measurement included in the analysis was quality-adjusted life years (QALY). The results of the analysis are presented as the incremental cost-effectiveness ratio (ICER). Results: Analysed biomarker-based diagnostic strategies for AKI were cost-effective compared to current diagnostic method. However, uNGAL and sCys C strategies yielded higher costs and lower effectiveness compared to uL-FABP strategy. uL-FABP added 1.43 QALY compared to current diagnostic method at an additional cost of $8521.87 per patient. Therefore, ICER for uL-FABP compared to sCr was $5959.35/QALY. Conclusions: Our results suggest that the use of uL-FABP would represent cost effective strategy for early diagnosis of AKI in children after cardiac surgery.",
publisher = "Croatian Soc Medical Biochemists, Zagreb",
journal = "Biochemia Medica",
title = "Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery",
volume = "25",
number = "2",
pages = "262-271",
doi = "10.11613/BM.2015.027"
}

Petrović, S., Bogavac-Stanojević, N., Lakić, D., Peco-Antić, A., Vulicević, I., Ivanišević, I., Kotur-Stevuljević, J.,& Jelić-Ivanović, Z.. (2015). Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery. in Biochemia Medica
Croatian Soc Medical Biochemists, Zagreb., 25(2), 262-271.
https://doi.org/10.11613/BM.2015.027

Petrović S, Bogavac-Stanojević N, Lakić D, Peco-Antić A, Vulicević I, Ivanišević I, Kotur-Stevuljević J, Jelić-Ivanović Z. Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery. in Biochemia Medica. 2015;25(2):262-271.
doi:10.11613/BM.2015.027 .

Petrović, Stanislava, Bogavac-Stanojević, Nataša, Lakić, Dragana, Peco-Antić, Amira, Vulicević, Irena, Ivanišević, Ivana, Kotur-Stevuljević, Jelena, Jelić-Ivanović, Zorana, "Cost-effectiveness analysis of acute kidney injury biomarkers in pediatric cardiac surgery" in Biochemia Medica, 25, no. 2 (2015):262-271,
https://doi.org/10.11613/BM.2015.027 . .

TY  - CONF
AU  - Bogavac-Stanojević, Nataša
AU  - Petrović, S.
AU  - Lakić, Dragana
AU  - Antić, Peco A.
AU  - Vulicević, Irena
AU  - Ivanišević, Ivana
AU  - Kotur-Stevuljević, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2111
AB  - Objectives: Children undergoing cardiac surgery for congenital heart disease are
more likely to experience development of acute kidney injury (AKI) in the immedi-
ate postoperative period. In current clinical practice, AKI diagnosis is based on a
rise in serum creatinine (sCr) levels, which occurs 2-3 days after the initiating renal
insult. Many new biomarkers offer promise for earlier AKI diagnosis. The objective was to assess the incremental cost effectiveness of using serum CysC (sCysC), urine
NGAL (uNGAL) and urine L-FABP (uL-FABP) for the diagnosis of AKI in children
after cardiac surgery compared with current diagnostic method (monitoring of sCr
level). MeThoDs: We developed a decision analytical model to estimate quality-
adjusted life years (QALY), lifetime costs and incremental cost-effectiveness of dif-
ferent biomarker-based diagnostic strategies which can be used in clinical practice
compared to current strategy.This model simulates detection of AKI, its progression
to chronic kidney disease (CKD) and CKD treatment in cohort of patients younger
than 18 years. ResulTs: The cost-effectiveness ratios were between $1485/QALY for
sCr and $3579/QALY for uNGAL. uNGAL and sCys C strategies yielded higher costs
and lower effectiveness (ie. dominated) compared to uL-FABP strategy. uL-FABP
added 1.43 QALY compared to current diagnostic method at an additional cost of
$8521.87. ICER for uL-FABP compared to sCr was $5959.35/QALY. Probabilistic sensi-
tivity analyses indicated that the uL-FABP strategy was cost-effective for all 10.000
patient simulations at specified $50000/QALY threshold. ConClusions: Our results
suggest that the use of uL-FABP is likely to represent an economically advantageous
strategy for early AKI diagnosis in children after cardiac surgery. However, we need
rapid screening uL-FABP test to ensure timely and efficient AKI treatment.
PB  - Elsevier Science Inc
C3  - Value in Health
T1  - Cost-effectiveness analysis of the new biomarkers for diagnosis of acute kidney injury in children after cardiac surgery
VL  - 17
IS  - 7
IS  - 7
SP  - A510
EP  - A511
DO  - 10.1016/j.jval.2014.08.1567
ER  - 

@conference{
author = "Bogavac-Stanojević, Nataša and Petrović, S. and Lakić, Dragana and Antić, Peco A. and Vulicević, Irena and Ivanišević, Ivana and Kotur-Stevuljević, Jelena and Jelić-Ivanović, Zorana",
year = "2014",
abstract = "Objectives: Children undergoing cardiac surgery for congenital heart disease are
more likely to experience development of acute kidney injury (AKI) in the immedi-
ate postoperative period. In current clinical practice, AKI diagnosis is based on a
rise in serum creatinine (sCr) levels, which occurs 2-3 days after the initiating renal
insult. Many new biomarkers offer promise for earlier AKI diagnosis. The objective was to assess the incremental cost effectiveness of using serum CysC (sCysC), urine
NGAL (uNGAL) and urine L-FABP (uL-FABP) for the diagnosis of AKI in children
after cardiac surgery compared with current diagnostic method (monitoring of sCr
level). MeThoDs: We developed a decision analytical model to estimate quality-
adjusted life years (QALY), lifetime costs and incremental cost-effectiveness of dif-
ferent biomarker-based diagnostic strategies which can be used in clinical practice
compared to current strategy.This model simulates detection of AKI, its progression
to chronic kidney disease (CKD) and CKD treatment in cohort of patients younger
than 18 years. ResulTs: The cost-effectiveness ratios were between $1485/QALY for
sCr and $3579/QALY for uNGAL. uNGAL and sCys C strategies yielded higher costs
and lower effectiveness (ie. dominated) compared to uL-FABP strategy. uL-FABP
added 1.43 QALY compared to current diagnostic method at an additional cost of
$8521.87. ICER for uL-FABP compared to sCr was $5959.35/QALY. Probabilistic sensi-
tivity analyses indicated that the uL-FABP strategy was cost-effective for all 10.000
patient simulations at specified $50000/QALY threshold. ConClusions: Our results
suggest that the use of uL-FABP is likely to represent an economically advantageous
strategy for early AKI diagnosis in children after cardiac surgery. However, we need
rapid screening uL-FABP test to ensure timely and efficient AKI treatment.",
publisher = "Elsevier Science Inc",
journal = "Value in Health",
title = "Cost-effectiveness analysis of the new biomarkers for diagnosis of acute kidney injury in children after cardiac surgery",
volume = "17",
number = "7, 7",
pages = "A510-A511",
doi = "10.1016/j.jval.2014.08.1567"
}

Bogavac-Stanojević, N., Petrović, S., Lakić, D., Antić, P. A., Vulicević, I., Ivanišević, I., Kotur-Stevuljević, J.,& Jelić-Ivanović, Z.. (2014). Cost-effectiveness analysis of the new biomarkers for diagnosis of acute kidney injury in children after cardiac surgery. in Value in Health
Elsevier Science Inc., 17(7), A510-A511.
https://doi.org/10.1016/j.jval.2014.08.1567

Bogavac-Stanojević N, Petrović S, Lakić D, Antić PA, Vulicević I, Ivanišević I, Kotur-Stevuljević J, Jelić-Ivanović Z. Cost-effectiveness analysis of the new biomarkers for diagnosis of acute kidney injury in children after cardiac surgery. in Value in Health. 2014;17(7):A510-A511.
doi:10.1016/j.jval.2014.08.1567 .

Bogavac-Stanojević, Nataša, Petrović, S., Lakić, Dragana, Antić, Peco A., Vulicević, Irena, Ivanišević, Ivana, Kotur-Stevuljević, Jelena, Jelić-Ivanović, Zorana, "Cost-effectiveness analysis of the new biomarkers for diagnosis of acute kidney injury in children after cardiac surgery" in Value in Health, 17, no. 7 (2014):A510-A511,
https://doi.org/10.1016/j.jval.2014.08.1567 . .

TY  - JOUR
AU  - Ivanišević, Ivana
AU  - Peco-Antić, Amira
AU  - Vulicević, Irena
AU  - Hercog, Đorđe
AU  - Milovanović, Vladimir
AU  - Kotur-Stevuljević, Jelena
AU  - Stefanović, Aleksandra
AU  - Kocev, Nikola
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1995
AB  - Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.
PB  - Springer, New York
T2  - Pediatric Nephrology
T1  - L-FABP can be an early marker of acute kidney injury in children
VL  - 28
IS  - 6
SP  - 963
EP  - 969
DO  - 10.1007/s00467-013-2421-z
ER  - 

@article{
author = "Ivanišević, Ivana and Peco-Antić, Amira and Vulicević, Irena and Hercog, Đorđe and Milovanović, Vladimir and Kotur-Stevuljević, Jelena and Stefanović, Aleksandra and Kocev, Nikola",
year = "2013",
abstract = "Acute kidney injury (AKI) is a common postoperative complication following cardiopulmonary bypass (CPB) surgery. New biomarkers to identify patients with early AKI (before increases in serum creatinine) are needed to facilitate appropriate treatment. This study aimed to test the role of urinary liver fatty-acid-binding protein (L-FABP) as an early biomarker for AKI in children undergoing CPB surgery. This is a case-control study of children undergoing CPB. AKI was defined as 50 % increase in serum creatinine at 48 h after surgery. For each patient, five serum and urine samples were obtained corresponding to time 0 h (presurgery) and 2, 6, 24, and 48 h after surgery. Twenty-seven patients, median age 360 days, were enrolled. AKI developed in 11 patients (41 %); three needed renal replacement therapy (peritoneal dialysis); there were two deaths. There were significant differences between patients with and without AKI in L-FABP levels at 2, 6, and 48 h after surgery, length of hospital stay, and CPB time; there were no differences in gender, patient age, and body weight. L-FABP was normalized to urinary creatinine concentration at all time points, with area under the receiver operator curve (AUC ROC) 0.867 at 2 and 6 h postoperatively. Correlation coefficient between L-FABP and length of hospital stay after surgery was statistically significant (r = 0.722, p value = 0.000). Our results suggest that urinary L-FABP can be used to diagnose AKI earlier than rise in serum creatinine in children undergoing CPB.",
publisher = "Springer, New York",
journal = "Pediatric Nephrology",
title = "L-FABP can be an early marker of acute kidney injury in children",
volume = "28",
number = "6",
pages = "963-969",
doi = "10.1007/s00467-013-2421-z"
}

Ivanišević, I., Peco-Antić, A., Vulicević, I., Hercog, Đ., Milovanović, V., Kotur-Stevuljević, J., Stefanović, A.,& Kocev, N.. (2013). L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology
Springer, New York., 28(6), 963-969.
https://doi.org/10.1007/s00467-013-2421-z

Ivanišević I, Peco-Antić A, Vulicević I, Hercog Đ, Milovanović V, Kotur-Stevuljević J, Stefanović A, Kocev N. L-FABP can be an early marker of acute kidney injury in children. in Pediatric Nephrology. 2013;28(6):963-969.
doi:10.1007/s00467-013-2421-z .

Ivanišević, Ivana, Peco-Antić, Amira, Vulicević, Irena, Hercog, Đorđe, Milovanović, Vladimir, Kotur-Stevuljević, Jelena, Stefanović, Aleksandra, Kocev, Nikola, "L-FABP can be an early marker of acute kidney injury in children" in Pediatric Nephrology, 28, no. 6 (2013):963-969,
https://doi.org/10.1007/s00467-013-2421-z . .

TY  - JOUR
AU  - Peco-Antić, Amira
AU  - Ivanišević, Ivana
AU  - Vulicević, Irena
AU  - Kotur-Stevuljević, Jelena
AU  - Ilić, Slobodan
AU  - Ivanišević, Jasmina
AU  - Miljković, Milica
AU  - Kocev, Nikola
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1893
AB  - Objectives: Acute kidney injury (AKI) is a significant problem in children undergoing cardiopulmonary bypass (CPB). The aims of this study were to assess the diagnostic validity of serum CysC (sCysC), serum neutrophil gelatinase lipocalin (sNGAL), urine neutrophil gelatinase lipocalin (uNGAL), urine kidney injury molecule (uKIM)-1, and urine liver fatty acid-binding protein (uL-FABP) to predict AKI presence and severity in children undergoing CPB. Design and methods: We performed a prospective single-center evaluation of sCysC, sNGAL, uNGAL, uKIM-1 and uL-FABP at 0, 2, 6, 24 and 48 h postoperatively in children undergoing CPB during cardiac surgery. AKI was defined as >= 25% decrease in the estimated creatinine clearance (eCCl) from pre-operative baseline at 48 h after surgery. Results: Of the 112 patients, 18 patients (16.1%) developed AKI; four of them needed acute dialysis treatment and three AKI patients died. In the AKI compared to the non-AM group, sCysC at 2 h, and uNGAL and uL-FABP at 2-48 h were significantly increased, as well as CPB, aortic cross clamp time and length of hospital stay. Biomarkers increased with worsening AKI severity. At 2 h after CPB the best accuracy for diagnosis of AKI had uL-FABP and sCysC with area under the receiver operator curve (AUC) of 0.89 and 0.73, respectively. At 6 and 24 h after CPB the best AUC was found for uL-FABP (0.75 and 0.87 respectively) and for uNGAL (0.70 and 0.93, respectively). Conclusions: sCysC, uNGAL and uL-FABP are reliable early predictors for AKI after CPB. By allowing earlier timing of injury and earlier intervention, they could improve AKI outcome.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Biomarkers of acute kidney injury in pediatric cardiac surgery
VL  - 46
IS  - 13-14
SP  - 1244
EP  - 1251
DO  - 10.1016/j.clinbiochem.2013.07.008
ER  - 

@article{
author = "Peco-Antić, Amira and Ivanišević, Ivana and Vulicević, Irena and Kotur-Stevuljević, Jelena and Ilić, Slobodan and Ivanišević, Jasmina and Miljković, Milica and Kocev, Nikola",
year = "2013",
abstract = "Objectives: Acute kidney injury (AKI) is a significant problem in children undergoing cardiopulmonary bypass (CPB). The aims of this study were to assess the diagnostic validity of serum CysC (sCysC), serum neutrophil gelatinase lipocalin (sNGAL), urine neutrophil gelatinase lipocalin (uNGAL), urine kidney injury molecule (uKIM)-1, and urine liver fatty acid-binding protein (uL-FABP) to predict AKI presence and severity in children undergoing CPB. Design and methods: We performed a prospective single-center evaluation of sCysC, sNGAL, uNGAL, uKIM-1 and uL-FABP at 0, 2, 6, 24 and 48 h postoperatively in children undergoing CPB during cardiac surgery. AKI was defined as >= 25% decrease in the estimated creatinine clearance (eCCl) from pre-operative baseline at 48 h after surgery. Results: Of the 112 patients, 18 patients (16.1%) developed AKI; four of them needed acute dialysis treatment and three AKI patients died. In the AKI compared to the non-AM group, sCysC at 2 h, and uNGAL and uL-FABP at 2-48 h were significantly increased, as well as CPB, aortic cross clamp time and length of hospital stay. Biomarkers increased with worsening AKI severity. At 2 h after CPB the best accuracy for diagnosis of AKI had uL-FABP and sCysC with area under the receiver operator curve (AUC) of 0.89 and 0.73, respectively. At 6 and 24 h after CPB the best AUC was found for uL-FABP (0.75 and 0.87 respectively) and for uNGAL (0.70 and 0.93, respectively). Conclusions: sCysC, uNGAL and uL-FABP are reliable early predictors for AKI after CPB. By allowing earlier timing of injury and earlier intervention, they could improve AKI outcome.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Biomarkers of acute kidney injury in pediatric cardiac surgery",
volume = "46",
number = "13-14",
pages = "1244-1251",
doi = "10.1016/j.clinbiochem.2013.07.008"
}

Peco-Antić, A., Ivanišević, I., Vulicević, I., Kotur-Stevuljević, J., Ilić, S., Ivanišević, J., Miljković, M.,& Kocev, N.. (2013). Biomarkers of acute kidney injury in pediatric cardiac surgery. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 46(13-14), 1244-1251.
https://doi.org/10.1016/j.clinbiochem.2013.07.008

Peco-Antić A, Ivanišević I, Vulicević I, Kotur-Stevuljević J, Ilić S, Ivanišević J, Miljković M, Kocev N. Biomarkers of acute kidney injury in pediatric cardiac surgery. in Clinical Biochemistry. 2013;46(13-14):1244-1251.
doi:10.1016/j.clinbiochem.2013.07.008 .

Peco-Antić, Amira, Ivanišević, Ivana, Vulicević, Irena, Kotur-Stevuljević, Jelena, Ilić, Slobodan, Ivanišević, Jasmina, Miljković, Milica, Kocev, Nikola, "Biomarkers of acute kidney injury in pediatric cardiac surgery" in Clinical Biochemistry, 46, no. 13-14 (2013):1244-1251,
https://doi.org/10.1016/j.clinbiochem.2013.07.008 . .