TY  - JOUR
AU  - Pavlović, Ivan
AU  - Radenković, Mirjana
AU  - Branković, Suzana
AU  - Milenković, Marina
AU  - Niketić, Marjan
AU  - Ušjak, Ljuboš
AU  - Petrović, Silvana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4084
AB  - Dry MeOH extract of Ferula heuffelii (Apiaceae) underground parts was tested for spasmolytic, gastroprotective and antioxidant activities. HPLC analysis revealed that chlorogenic acid (CGA; 34.6 mg/g) was its main constituent. Extract in vitro exhibited notable total antioxidant activity (FRAP value=1.0 μmol Fe2+/mg), and scavenging of DPPH (SC50=62.5 μg/ml) and •OH radicals (49.5 % at 20 μg/ml in 2-deoxyribose assay). In vitro on isolated rat ileum, extract exhibited significant spasmolytic activity, i. e., it showed 124.6 % of maximal atropine effect on spontaneous contractions (at 100 μg/ml), and reduced spasmogenic effect of KCl (80 mm) to 44.4 % (at 60 μg/ml) and of highest applied concentration of ACh to 26.3 % (at 120 μg/ml). In parallel experiments, spasmolytic effect of CGA was also demonstrated. In acute EtOH-induced gastric ulceration model in rats, extract (100 mg/kg p.o.) showed significant gastroprotective effect (gastric damage score 0.50), similar to ranitidine (20 mg/kg p.o.). Obtained results showed that tested F. heuffelii polar extract represents new herbal preparation with potential use against some gastrointestinal complaints.
PB  - John Wiley and Sons Inc
T2  - Chemistry and Biodiversity
T1  - Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts
VL  - 19
IS  - 5
DO  - 10.1002/cbdv.202200047
ER  - 

@article{
author = "Pavlović, Ivan and Radenković, Mirjana and Branković, Suzana and Milenković, Marina and Niketić, Marjan and Ušjak, Ljuboš and Petrović, Silvana",
year = "2022",
abstract = "Dry MeOH extract of Ferula heuffelii (Apiaceae) underground parts was tested for spasmolytic, gastroprotective and antioxidant activities. HPLC analysis revealed that chlorogenic acid (CGA; 34.6 mg/g) was its main constituent. Extract in vitro exhibited notable total antioxidant activity (FRAP value=1.0 μmol Fe2+/mg), and scavenging of DPPH (SC50=62.5 μg/ml) and •OH radicals (49.5 % at 20 μg/ml in 2-deoxyribose assay). In vitro on isolated rat ileum, extract exhibited significant spasmolytic activity, i. e., it showed 124.6 % of maximal atropine effect on spontaneous contractions (at 100 μg/ml), and reduced spasmogenic effect of KCl (80 mm) to 44.4 % (at 60 μg/ml) and of highest applied concentration of ACh to 26.3 % (at 120 μg/ml). In parallel experiments, spasmolytic effect of CGA was also demonstrated. In acute EtOH-induced gastric ulceration model in rats, extract (100 mg/kg p.o.) showed significant gastroprotective effect (gastric damage score 0.50), similar to ranitidine (20 mg/kg p.o.). Obtained results showed that tested F. heuffelii polar extract represents new herbal preparation with potential use against some gastrointestinal complaints.",
publisher = "John Wiley and Sons Inc",
journal = "Chemistry and Biodiversity",
title = "Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts",
volume = "19",
number = "5",
doi = "10.1002/cbdv.202200047"
}

Pavlović, I., Radenković, M., Branković, S., Milenković, M., Niketić, M., Ušjak, L.,& Petrović, S.. (2022). Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts. in Chemistry and Biodiversity
John Wiley and Sons Inc., 19(5).
https://doi.org/10.1002/cbdv.202200047

Pavlović I, Radenković M, Branković S, Milenković M, Niketić M, Ušjak L, Petrović S. Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts. in Chemistry and Biodiversity. 2022;19(5).
doi:10.1002/cbdv.202200047 .

Pavlović, Ivan, Radenković, Mirjana, Branković, Suzana, Milenković, Marina, Niketić, Marjan, Ušjak, Ljuboš, Petrović, Silvana, "Spasmolytic, Gastroprotective and Antioxidant Activities of Dry Methanol Extract of Ferula heuffelii Underground Parts" in Chemistry and Biodiversity, 19, no. 5 (2022),
https://doi.org/10.1002/cbdv.202200047 . .

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Omar, Eihab
AU  - Drobac, Milica
AU  - Radenković, Mirjana
AU  - Branković, Suzana
AU  - Kovačević, Nada
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2831
AB  - The plants of genus Cymbopogon are well known for their use in traditional medicine and for their high content of essential oils that are widely used as flavoring agents, fragrances, cosmetics, and pharmaceuticals. Essential oils isolated from the dried stems and inflorescence of cultivated Cymbopogon schoenanthus (L.) Spreng. (Poaceae) collected from Khartoum state (Sudan) in two periods were studied. The results of chemical analysis of C. schoenanthus revealed that this plant is rich in essential oil which is a valuable source of the commercially important monoterpene, piperitone (47.7-71.5%). Other abundant constituents of the oils were intermedeol (6.1-17.3%), delta-2-carene (4.5-10.0%) and elemol (2.7-9.0%). The essential oil from the inflorescence was tested for spasmolytic activity using three different experimental models: against spontaneous contractions, contractions induced with acetylcholine and contractions induced with potassium chloride. The oil exhibited strong, significant and dose-dependent spasmolytic activity, indicating the possibility for further investigations of this essential oil for its medicinal purposes or application in food industry.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Chemical composition and spasmolytic activity of Cymbopogon schoenanthus (L.) Spreng. (Poaceae) essential oil from Sudan
VL  - 69
IS  - 3
SP  - 409
EP  - 415
DO  - 10.2298/ABS160506113P
ER  - 

@article{
author = "Pavlović, Ivan and Omar, Eihab and Drobac, Milica and Radenković, Mirjana and Branković, Suzana and Kovačević, Nada",
year = "2017",
abstract = "The plants of genus Cymbopogon are well known for their use in traditional medicine and for their high content of essential oils that are widely used as flavoring agents, fragrances, cosmetics, and pharmaceuticals. Essential oils isolated from the dried stems and inflorescence of cultivated Cymbopogon schoenanthus (L.) Spreng. (Poaceae) collected from Khartoum state (Sudan) in two periods were studied. The results of chemical analysis of C. schoenanthus revealed that this plant is rich in essential oil which is a valuable source of the commercially important monoterpene, piperitone (47.7-71.5%). Other abundant constituents of the oils were intermedeol (6.1-17.3%), delta-2-carene (4.5-10.0%) and elemol (2.7-9.0%). The essential oil from the inflorescence was tested for spasmolytic activity using three different experimental models: against spontaneous contractions, contractions induced with acetylcholine and contractions induced with potassium chloride. The oil exhibited strong, significant and dose-dependent spasmolytic activity, indicating the possibility for further investigations of this essential oil for its medicinal purposes or application in food industry.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Chemical composition and spasmolytic activity of Cymbopogon schoenanthus (L.) Spreng. (Poaceae) essential oil from Sudan",
volume = "69",
number = "3",
pages = "409-415",
doi = "10.2298/ABS160506113P"
}

Pavlović, I., Omar, E., Drobac, M., Radenković, M., Branković, S.,& Kovačević, N.. (2017). Chemical composition and spasmolytic activity of Cymbopogon schoenanthus (L.) Spreng. (Poaceae) essential oil from Sudan. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 69(3), 409-415.
https://doi.org/10.2298/ABS160506113P

Pavlović I, Omar E, Drobac M, Radenković M, Branković S, Kovačević N. Chemical composition and spasmolytic activity of Cymbopogon schoenanthus (L.) Spreng. (Poaceae) essential oil from Sudan. in Archives of Biological Sciences. 2017;69(3):409-415.
doi:10.2298/ABS160506113P .

Pavlović, Ivan, Omar, Eihab, Drobac, Milica, Radenković, Mirjana, Branković, Suzana, Kovačević, Nada, "Chemical composition and spasmolytic activity of Cymbopogon schoenanthus (L.) Spreng. (Poaceae) essential oil from Sudan" in Archives of Biological Sciences, 69, no. 3 (2017):409-415,
https://doi.org/10.2298/ABS160506113P . .

TY  - JOUR
AU  - Omar, Eihab
AU  - Pavlović, Ivan
AU  - Drobac, Milica
AU  - Radenković, Mirjana
AU  - Branković, Suzana
AU  - Kovačević, Nada
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2741
AB  - The composition of essential oils obtained by hydrodistillation from dried stems and inflorescences of Cymbopogon nervatus (Hochst.) Chiov. (Poaceae) growing wild in Western and Eastern Sudan and collected at two different periods, was analyzed by GC and GC MS. The most dominant constituents in the oils were p-menthadienols, trans-p-mentha-1(7),8-dien-2-ol (19.9-32.6%), cis-p-mentha-1(7),8-dien-2-ol (18.9-23.3%), trans-p-mentha-2,8-dien-l-ol (10.6-21.0%) and cis-p-mentha-2,8-dien-1-ol (8.1-10.4%). The essential oil of inflorescence from the Western Sudan was tested for spasmolytic activity using three different experimental models: against spontaneous contractions, and contractions induced with ACh and KCI. The oil exhibited strong, significant and concentration-dependent spasmolytic activity. Applied in concentration of 200 mu g/ml, the oil showed 88.44 +/- 16.78% of maximal spasmolytic effect of atropine (6.4 p,,M) against spontaneous contraction. Essential oil (90 mu g/ml) inhibited ACh-induced contractions as well, and reduced the effect of the highest applied concentration of ACh to 37.29 +/- 16.16%. Additionally, the oil exhibited strong activity against contractions induced with KCI (80 mM) and in concentration of 200 mu g/ml, completely abolished the contractile effect of KCI. The essential oil of inflorescence from the Western Sudan was also tested for antioxidant activity by DPPH assay and showed moderate anti-DPPH activity (SC50 23.8 mu l/ml).
PB  - Elsevier Science BV, Amsterdam
T2  - Industrial Crops and Products
T1  - Chemical composition and spasmolytic activity of Cymbopogon nervatus (Hochst.) Chiov. (Poaceae) essential oil
VL  - 91
SP  - 249
EP  - 254
DO  - 10.1016/j.indcrop.2016.07.013
ER  - 

@article{
author = "Omar, Eihab and Pavlović, Ivan and Drobac, Milica and Radenković, Mirjana and Branković, Suzana and Kovačević, Nada",
year = "2016",
abstract = "The composition of essential oils obtained by hydrodistillation from dried stems and inflorescences of Cymbopogon nervatus (Hochst.) Chiov. (Poaceae) growing wild in Western and Eastern Sudan and collected at two different periods, was analyzed by GC and GC MS. The most dominant constituents in the oils were p-menthadienols, trans-p-mentha-1(7),8-dien-2-ol (19.9-32.6%), cis-p-mentha-1(7),8-dien-2-ol (18.9-23.3%), trans-p-mentha-2,8-dien-l-ol (10.6-21.0%) and cis-p-mentha-2,8-dien-1-ol (8.1-10.4%). The essential oil of inflorescence from the Western Sudan was tested for spasmolytic activity using three different experimental models: against spontaneous contractions, and contractions induced with ACh and KCI. The oil exhibited strong, significant and concentration-dependent spasmolytic activity. Applied in concentration of 200 mu g/ml, the oil showed 88.44 +/- 16.78% of maximal spasmolytic effect of atropine (6.4 p,,M) against spontaneous contraction. Essential oil (90 mu g/ml) inhibited ACh-induced contractions as well, and reduced the effect of the highest applied concentration of ACh to 37.29 +/- 16.16%. Additionally, the oil exhibited strong activity against contractions induced with KCI (80 mM) and in concentration of 200 mu g/ml, completely abolished the contractile effect of KCI. The essential oil of inflorescence from the Western Sudan was also tested for antioxidant activity by DPPH assay and showed moderate anti-DPPH activity (SC50 23.8 mu l/ml).",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Industrial Crops and Products",
title = "Chemical composition and spasmolytic activity of Cymbopogon nervatus (Hochst.) Chiov. (Poaceae) essential oil",
volume = "91",
pages = "249-254",
doi = "10.1016/j.indcrop.2016.07.013"
}

Omar, E., Pavlović, I., Drobac, M., Radenković, M., Branković, S.,& Kovačević, N.. (2016). Chemical composition and spasmolytic activity of Cymbopogon nervatus (Hochst.) Chiov. (Poaceae) essential oil. in Industrial Crops and Products
Elsevier Science BV, Amsterdam., 91, 249-254.
https://doi.org/10.1016/j.indcrop.2016.07.013

Omar E, Pavlović I, Drobac M, Radenković M, Branković S, Kovačević N. Chemical composition and spasmolytic activity of Cymbopogon nervatus (Hochst.) Chiov. (Poaceae) essential oil. in Industrial Crops and Products. 2016;91:249-254.
doi:10.1016/j.indcrop.2016.07.013 .

Omar, Eihab, Pavlović, Ivan, Drobac, Milica, Radenković, Mirjana, Branković, Suzana, Kovačević, Nada, "Chemical composition and spasmolytic activity of Cymbopogon nervatus (Hochst.) Chiov. (Poaceae) essential oil" in Industrial Crops and Products, 91 (2016):249-254,
https://doi.org/10.1016/j.indcrop.2016.07.013 . .

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Petrović, Silvana
AU  - Milenković, Marina
AU  - Stanojković, Tatjana
AU  - Nikolić, Dejan
AU  - Krunić, Aleksej
AU  - Niketić, Marjan
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2330
AB  - The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffeliiGriseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5g/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5g/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2M, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5M, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2M). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 lt 11.0g/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50=22.32 +/- 1.32 vs. 18.67 +/- 0.75M).
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Chemistry & Biodiversity
T1  - Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites
VL  - 12
IS  - 10
SP  - 1585
EP  - 1594
DO  - 10.1002/cbdv.201400400
ER  - 

@article{
author = "Pavlović, Ivan and Petrović, Silvana and Milenković, Marina and Stanojković, Tatjana and Nikolić, Dejan and Krunić, Aleksej and Niketić, Marjan",
year = "2015",
abstract = "The antimicrobial and cytotoxic activities of isolates (CHCl3 and MeOH extracts and selected metabolites) obtained from the underground parts of the Balkan endemic plant Ferula heuffeliiGriseb. ex Heuff. were assessed. The CHCl3 and MeOH extracts exhibited moderate antimicrobial activity, being more pronounced against Gram-positive than Gram-negative bacteria, especially against Staphylococcus aureus (MIC=12.5g/ml for both extracts) and Micrococcus luteus (MIC=50 and 12.5g/ml, resp.). Among the tested metabolites, (6E)-1-(2,4-dihydroxyphenyl)-3,7,11-trimethyl-3-vinyldodeca-6,10-dien-1-one (2) and (2S*,3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro-7-hydroxy-2,3-dimethylfuro[3,2-c]coumarin (4) demonstrated the best antimicrobial activity. Compounds 2 and 4 both strongly inhibited the growth of M. luteus (MIC=11.2 and 5.2M, resp.) and Staphylococcus epidermidis (MIC=22.5 and 10.5M, resp.) and compound 2 additionally also the growth of Bacillus subtilis (MIC=11.2M). The cytotoxic activity of the isolates was tested against three human cancer cell lines, viz., cervical adenocarcinoma (HeLa), chronic myelogenous leukemia (K562), and breast cancer (MCF-7) cells. The CHCl3 extract exhibited strong cytotoxic activity against all cell lines (IC50 lt 11.0g/ml). All compounds strongly inhibited the growth of the K562 and HeLa cell lines. Compound 4 exhibited also a strong activity against the MCF-7 cell line, comparable to that of cisplatin (IC50=22.32 +/- 1.32 vs. 18.67 +/- 0.75M).",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites",
volume = "12",
number = "10",
pages = "1585-1594",
doi = "10.1002/cbdv.201400400"
}

Pavlović, I., Petrović, S., Milenković, M., Stanojković, T., Nikolić, D., Krunić, A.,& Niketić, M.. (2015). Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites. in Chemistry & Biodiversity
Wiley-VCH Verlag GMBH, Weinheim., 12(10), 1585-1594.
https://doi.org/10.1002/cbdv.201400400

Pavlović I, Petrović S, Milenković M, Stanojković T, Nikolić D, Krunić A, Niketić M. Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites. in Chemistry & Biodiversity. 2015;12(10):1585-1594.
doi:10.1002/cbdv.201400400 .

Pavlović, Ivan, Petrović, Silvana, Milenković, Marina, Stanojković, Tatjana, Nikolić, Dejan, Krunić, Aleksej, Niketić, Marjan, "Antimicrobial and Cytotoxic Activity of Extracts of Ferula heuffelii Griseb. ex Heuff. and Its Metabolites" in Chemistry & Biodiversity, 12, no. 10 (2015):1585-1594,
https://doi.org/10.1002/cbdv.201400400 . .

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Krunić, Aleksej
AU  - Nikolić, Dejan
AU  - Radenković, Mirjana
AU  - Branković, Suzana
AU  - Niketić, Marjan
AU  - Petrović, Silvana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2077
AB  - Plants from the genus Ferula L. (Apiaceae) were used for various purposes in traditional medicine of different nations throughout the history. Ferula heuffelii GRISEB. ex HEUFFEL is a perennial species endemic for Balkan peninsula. Ten compounds which belong to classes of prenyl-furocoumarin-, prenyl-dihydrofurochromone-, prenyl-benzoyl-and prenyl-benzoylfuranone-type sesquiterpenoids, as well as sesquiterpene coumarins and phenylpropanoids, were, for the first time, isolated from the CHCl3 extract of the underground parts of this plant and identified. Furthermore, extract and three isolated compounds, i.e., latifolone (1), dshamirone (4), and (2S*, 3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro7- hydroxy-2,3-dimethylfuro[3,2-c] coumarin (6) were, for the first time, evaluated for their in vitro antispasmodic activities in three experimental models: spontaneous contraction, and ACh- and KCl-induced contraction of an isolated rat ileum. The extract (0.1-1.3 mg/ml) and compound 6 (1 - 10 mu g/ml) exhibited dose-dependent effect in all three models. Compound 1 (1-6 mu g/ml) affected spontaneous contractions and those induced by KCl, while compound 4 (8 mu g/ml) displayed only moderate activity with ACh-induced contractions. It can be concluded that tested compounds contribute to exhibited antispasmodic activity of crude extract. Additionally, extract (0.1-1.3 mg/ml) was tested for in vitro relaxant activity on an isolated rat trachea, and relaxed the KCl-induced contractions in a dose-dependent manner.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Chemistry & Biodiversity
T1  - Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity
VL  - 11
IS  - 9
SP  - 1417
EP  - 1427
DO  - 10.1002/cbdv.201400094
ER  - 

@article{
author = "Pavlović, Ivan and Krunić, Aleksej and Nikolić, Dejan and Radenković, Mirjana and Branković, Suzana and Niketić, Marjan and Petrović, Silvana",
year = "2014",
abstract = "Plants from the genus Ferula L. (Apiaceae) were used for various purposes in traditional medicine of different nations throughout the history. Ferula heuffelii GRISEB. ex HEUFFEL is a perennial species endemic for Balkan peninsula. Ten compounds which belong to classes of prenyl-furocoumarin-, prenyl-dihydrofurochromone-, prenyl-benzoyl-and prenyl-benzoylfuranone-type sesquiterpenoids, as well as sesquiterpene coumarins and phenylpropanoids, were, for the first time, isolated from the CHCl3 extract of the underground parts of this plant and identified. Furthermore, extract and three isolated compounds, i.e., latifolone (1), dshamirone (4), and (2S*, 3R*)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2,3-dihydro7- hydroxy-2,3-dimethylfuro[3,2-c] coumarin (6) were, for the first time, evaluated for their in vitro antispasmodic activities in three experimental models: spontaneous contraction, and ACh- and KCl-induced contraction of an isolated rat ileum. The extract (0.1-1.3 mg/ml) and compound 6 (1 - 10 mu g/ml) exhibited dose-dependent effect in all three models. Compound 1 (1-6 mu g/ml) affected spontaneous contractions and those induced by KCl, while compound 4 (8 mu g/ml) displayed only moderate activity with ACh-induced contractions. It can be concluded that tested compounds contribute to exhibited antispasmodic activity of crude extract. Additionally, extract (0.1-1.3 mg/ml) was tested for in vitro relaxant activity on an isolated rat trachea, and relaxed the KCl-induced contractions in a dose-dependent manner.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Chemistry & Biodiversity",
title = "Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity",
volume = "11",
number = "9",
pages = "1417-1427",
doi = "10.1002/cbdv.201400094"
}

Pavlović, I., Krunić, A., Nikolić, D., Radenković, M., Branković, S., Niketić, M.,& Petrović, S.. (2014). Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity. in Chemistry & Biodiversity
Wiley-VCH Verlag GMBH, Weinheim., 11(9), 1417-1427.
https://doi.org/10.1002/cbdv.201400094

Pavlović I, Krunić A, Nikolić D, Radenković M, Branković S, Niketić M, Petrović S. Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity. in Chemistry & Biodiversity. 2014;11(9):1417-1427.
doi:10.1002/cbdv.201400094 .

Pavlović, Ivan, Krunić, Aleksej, Nikolić, Dejan, Radenković, Mirjana, Branković, Suzana, Niketić, Marjan, Petrović, Silvana, "Chloroform Extract of Underground Parts of Ferula heuffelii: Secondary Metabolites and Spasmolytic Activity" in Chemistry & Biodiversity, 11, no. 9 (2014):1417-1427,
https://doi.org/10.1002/cbdv.201400094 . .

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Petrović, Silvana
AU  - Radenković, Mirjana
AU  - Milenković, Marina
AU  - Couladis, Maria
AU  - Branković, Suzana
AU  - Drobac, Milica
AU  - Niketić, Marjan
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1718
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Corrigendum to ‘‘Composition, antimicrobial, antiradical and spasmolytic activity
of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil’’
VL  - 131
IS  - 2
SP  - 691
EP  - 691
DO  - 10.1016/j.foodchem.2011.09.003
ER  - 

@article{
author = "Pavlović, Ivan and Petrović, Silvana and Radenković, Mirjana and Milenković, Marina and Couladis, Maria and Branković, Suzana and Drobac, Milica and Niketić, Marjan",
year = "2012",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Corrigendum to ‘‘Composition, antimicrobial, antiradical and spasmolytic activity
of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil’’",
volume = "131",
number = "2",
pages = "691-691",
doi = "10.1016/j.foodchem.2011.09.003"
}

Pavlović, I., Petrović, S., Radenković, M., Milenković, M., Couladis, M., Branković, S., Drobac, M.,& Niketić, M.. (2012). Corrigendum to ‘‘Composition, antimicrobial, antiradical and spasmolytic activity
of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil’’. in Food Chemistry
Elsevier Sci Ltd, Oxford., 131(2), 691-691.
https://doi.org/10.1016/j.foodchem.2011.09.003

Pavlović I, Petrović S, Radenković M, Milenković M, Couladis M, Branković S, Drobac M, Niketić M. Corrigendum to ‘‘Composition, antimicrobial, antiradical and spasmolytic activity
of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil’’. in Food Chemistry. 2012;131(2):691-691.
doi:10.1016/j.foodchem.2011.09.003 .

Pavlović, Ivan, Petrović, Silvana, Radenković, Mirjana, Milenković, Marina, Couladis, Maria, Branković, Suzana, Drobac, Milica, Niketić, Marjan, "Corrigendum to ‘‘Composition, antimicrobial, antiradical and spasmolytic activity
of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil’’" in Food Chemistry, 131, no. 2 (2012):691-691,
https://doi.org/10.1016/j.foodchem.2011.09.003 . .

TY  - JOUR
AU  - Pavlović, Ivan
AU  - Petrović, Silvana
AU  - Radenković, Mirjana
AU  - Milenković, Marina
AU  - Couladis, Maria
AU  - Branković, Suzana
AU  - Drobac, Milica
AU  - Niketić, Marjan
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1715
AB  - The essential oil from underground parts of Ferula heuffelii from N.E. Serbia, was analysed using GC and GC-MS. The main compounds of the essential oil were elemicin (35.4%) and myristicin (20.6%). The essential oil exhibited the best antimicrobial activity against two strains of Candida albicans (MIC = 7.0 and 13.7 mu g/ml), as well as against Micrococcus luteus (MIC = 13.7 mu g/ml), Staphylococcus epidermidis (MIC = 17.6 mu g/ml), Bacillus subtilis (MIC = 21.1 mu g/ml) and Micrococcus flavus (MIC = 28.2 mu g/ml). In the DPPH radical scavenging assay, essential oil showed substantial activity with SC(50) = 22.43 mu l/ml. The essential oil was also tested for antispasmodic activity. It inhibited spontaneous contraction of isolated rat ileum dose-dependently, and at the concentration of 86.64 mu g/ml exhibited 50% of the maximum effect of atropine. After incubation with 75.00 mu g/ml of essential oil, acetylcholine did not induce contractions of ileum, and at 250.00 mu g/ml, the essential oil almost completely abolished the spasmodic effect of potassium chloride (80 mM).
PB  - Elsevier Sci Ltd, Oxford
T2  - Food Chemistry
T1  - Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil
VL  - 130
IS  - 2
SP  - 310
EP  - 315
DO  - 10.1016/j.foodchem.2011.07.043
ER  - 

@article{
author = "Pavlović, Ivan and Petrović, Silvana and Radenković, Mirjana and Milenković, Marina and Couladis, Maria and Branković, Suzana and Drobac, Milica and Niketić, Marjan",
year = "2012",
abstract = "The essential oil from underground parts of Ferula heuffelii from N.E. Serbia, was analysed using GC and GC-MS. The main compounds of the essential oil were elemicin (35.4%) and myristicin (20.6%). The essential oil exhibited the best antimicrobial activity against two strains of Candida albicans (MIC = 7.0 and 13.7 mu g/ml), as well as against Micrococcus luteus (MIC = 13.7 mu g/ml), Staphylococcus epidermidis (MIC = 17.6 mu g/ml), Bacillus subtilis (MIC = 21.1 mu g/ml) and Micrococcus flavus (MIC = 28.2 mu g/ml). In the DPPH radical scavenging assay, essential oil showed substantial activity with SC(50) = 22.43 mu l/ml. The essential oil was also tested for antispasmodic activity. It inhibited spontaneous contraction of isolated rat ileum dose-dependently, and at the concentration of 86.64 mu g/ml exhibited 50% of the maximum effect of atropine. After incubation with 75.00 mu g/ml of essential oil, acetylcholine did not induce contractions of ileum, and at 250.00 mu g/ml, the essential oil almost completely abolished the spasmodic effect of potassium chloride (80 mM).",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Food Chemistry",
title = "Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil",
volume = "130",
number = "2",
pages = "310-315",
doi = "10.1016/j.foodchem.2011.07.043"
}

Pavlović, I., Petrović, S., Radenković, M., Milenković, M., Couladis, M., Branković, S., Drobac, M.,& Niketić, M.. (2012). Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil. in Food Chemistry
Elsevier Sci Ltd, Oxford., 130(2), 310-315.
https://doi.org/10.1016/j.foodchem.2011.07.043

Pavlović I, Petrović S, Radenković M, Milenković M, Couladis M, Branković S, Drobac M, Niketić M. Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil. in Food Chemistry. 2012;130(2):310-315.
doi:10.1016/j.foodchem.2011.07.043 .

Pavlović, Ivan, Petrović, Silvana, Radenković, Mirjana, Milenković, Marina, Couladis, Maria, Branković, Suzana, Drobac, Milica, Niketić, Marjan, "Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil" in Food Chemistry, 130, no. 2 (2012):310-315,
https://doi.org/10.1016/j.foodchem.2011.07.043 . .