TY  - DATA
AU  - Kotur-Stevuljević, Jelena
AU  - Roksandić-Milenković, Marina
AU  - Dimić, Nemanja
AU  - Dimić, Dejan
AU  - Ćujić, Danica
AU  - Vekić, Jelena
AU  - Guzonjić, Azra
AU  - Gagić, Jelena
AU  - Timotijević, Ljiljana
AU  - Žujović, Dejan
AU  - Gnjatović, Marija
AU  - Todorović, Aleksandra
AU  - Bogavac-Stanojević, Nataša
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5108
AB  - Background A three-year COVID-19 pandemic revealed a spectrum of disease severity and clinical manifestations. The most intriguing part of this phenomenon lays in interindividual variability in COVID-19 course among patients, which is attributable to patient's age, comorbidities and general health status. Focus of this follow-up study was to assess leukocyte telomere length change in mild-to-moderate COVID-19 patients and concomitant influence of inflammation, oxidative stress (OS), pulmonary involvement and implemented therapy on the course of the disease.

Material and methods Routine biochemical/haematological parameters, markers of OS (prooxidants and antioxidants), vitamin D, IgM and IgG antibodies level and relative length of leukocyte telomeres (rLTL) were measured at three time-points (at diagnosis, after 14 and 21 days from the disease onset) in blood samples of 31 consecutive COVID-19 patients, with a mild (n=16) and moderate (n=15) form of the disease, treated on an outpatient basis.

Results Although the patients had reduced rLTL at baseline (median: 0.592; 25th – 75th percentiles: 0.518-0.724), it significantly increased during the follow-up (median: 0.773; 25th – 75th percentiles: 0.615-0.923; P<0.01). The rate of telomere attrition was associated with the extent of OS and pulmonary involvement. During follow-up, the burden of OS was reduced, while antioxidative defence mechanisms were recovered. The use of antibiotics and N-acetylcysteine-propolis supplementation was associated with telomere lengthening.

Conclusion Results of this study revealed significant interaction between OS, inflammation and leukocyte telomere length attrition in COVID-19. Our data suggest that rRTL can be a biomarker that enables more precise therapy decision and accurate patient status estimation.
PB  - Hindawi
T1  - Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5108
ER  - 

@misc{
author = "Kotur-Stevuljević, Jelena and Roksandić-Milenković, Marina and Dimić, Nemanja and Dimić, Dejan and Ćujić, Danica and Vekić, Jelena and Guzonjić, Azra and Gagić, Jelena and Timotijević, Ljiljana and Žujović, Dejan and Gnjatović, Marija and Todorović, Aleksandra and Bogavac-Stanojević, Nataša",
year = "2023",
abstract = "Background A three-year COVID-19 pandemic revealed a spectrum of disease severity and clinical manifestations. The most intriguing part of this phenomenon lays in interindividual variability in COVID-19 course among patients, which is attributable to patient's age, comorbidities and general health status. Focus of this follow-up study was to assess leukocyte telomere length change in mild-to-moderate COVID-19 patients and concomitant influence of inflammation, oxidative stress (OS), pulmonary involvement and implemented therapy on the course of the disease.

Material and methods Routine biochemical/haematological parameters, markers of OS (prooxidants and antioxidants), vitamin D, IgM and IgG antibodies level and relative length of leukocyte telomeres (rLTL) were measured at three time-points (at diagnosis, after 14 and 21 days from the disease onset) in blood samples of 31 consecutive COVID-19 patients, with a mild (n=16) and moderate (n=15) form of the disease, treated on an outpatient basis.

Results Although the patients had reduced rLTL at baseline (median: 0.592; 25th – 75th percentiles: 0.518-0.724), it significantly increased during the follow-up (median: 0.773; 25th – 75th percentiles: 0.615-0.923; P<0.01). The rate of telomere attrition was associated with the extent of OS and pulmonary involvement. During follow-up, the burden of OS was reduced, while antioxidative defence mechanisms were recovered. The use of antibiotics and N-acetylcysteine-propolis supplementation was associated with telomere lengthening.

Conclusion Results of this study revealed significant interaction between OS, inflammation and leukocyte telomere length attrition in COVID-19. Our data suggest that rRTL can be a biomarker that enables more precise therapy decision and accurate patient status estimation.",
publisher = "Hindawi",
title = "Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5108"
}

Kotur-Stevuljević, J., Roksandić-Milenković, M., Dimić, N., Dimić, D., Ćujić, D., Vekić, J., Guzonjić, A., Gagić, J., Timotijević, L., Žujović, D., Gnjatović, M., Todorović, A.,& Bogavac-Stanojević, N.. (2023). Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy. 
Hindawi..
https://hdl.handle.net/21.15107/rcub_farfar_5108

Kotur-Stevuljević J, Roksandić-Milenković M, Dimić N, Dimić D, Ćujić D, Vekić J, Guzonjić A, Gagić J, Timotijević L, Žujović D, Gnjatović M, Todorović A, Bogavac-Stanojević N. Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy. 2023;.
https://hdl.handle.net/21.15107/rcub_farfar_5108 .

Kotur-Stevuljević, Jelena, Roksandić-Milenković, Marina, Dimić, Nemanja, Dimić, Dejan, Ćujić, Danica, Vekić, Jelena, Guzonjić, Azra, Gagić, Jelena, Timotijević, Ljiljana, Žujović, Dejan, Gnjatović, Marija, Todorović, Aleksandra, Bogavac-Stanojević, Nataša, "Supplementary material for the article: Kotur-Stevuljević, J.; Roksandić-Milenković, M.; Dimić, N. ...et. al. Leukocyte telomere dynamic change in patients with mild to moderate COVID-19 during three weeks of follow-up: relation with therapy" (2023),
https://hdl.handle.net/21.15107/rcub_farfar_5108 .

TY  - CONF
AU  - Jovanović, Aleksandar
AU  - Catić Ðorđević, Aleksandra
AU  - Dimić, Nemanja
AU  - Milošević-Georgiev, Andrijana
AU  - Tadić, Ivana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5493
AB  - Background Urinary tract infections (UTIs) are among the most common bacterial infections, mainly affecting the female population. The annual incidence of UTI in the male population aged 17–79 is 2.2%, while 12% of men reported symptoms of urinary infections at least once. ...
PB  - Springer
C3  - International Journal of Clinical Pharmacy
T1  - Urinary tract health in the male population in the Republic of Serbia—part II
VL  - 45
IS  - 2
SP  - 538
EP  - 538
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5493
ER  - 

@conference{
author = "Jovanović, Aleksandar and Catić Ðorđević, Aleksandra and Dimić, Nemanja and Milošević-Georgiev, Andrijana and Tadić, Ivana",
year = "2023",
abstract = "Background Urinary tract infections (UTIs) are among the most common bacterial infections, mainly affecting the female population. The annual incidence of UTI in the male population aged 17–79 is 2.2%, while 12% of men reported symptoms of urinary infections at least once. ...",
publisher = "Springer",
journal = "International Journal of Clinical Pharmacy",
title = "Urinary tract health in the male population in the Republic of Serbia—part II",
volume = "45",
number = "2",
pages = "538-538",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5493"
}

Jovanović, A., Catić Ðorđević, A., Dimić, N., Milošević-Georgiev, A.,& Tadić, I.. (2023). Urinary tract health in the male population in the Republic of Serbia—part II. in International Journal of Clinical Pharmacy
Springer., 45(2), 538-538.
https://hdl.handle.net/21.15107/rcub_farfar_5493

Jovanović A, Catić Ðorđević A, Dimić N, Milošević-Georgiev A, Tadić I. Urinary tract health in the male population in the Republic of Serbia—part II. in International Journal of Clinical Pharmacy. 2023;45(2):538-538.
https://hdl.handle.net/21.15107/rcub_farfar_5493 .

Jovanović, Aleksandar, Catić Ðorđević, Aleksandra, Dimić, Nemanja, Milošević-Georgiev, Andrijana, Tadić, Ivana, "Urinary tract health in the male population in the Republic of Serbia—part II" in International Journal of Clinical Pharmacy, 45, no. 2 (2023):538-538,
https://hdl.handle.net/21.15107/rcub_farfar_5493 .

TY  - CONF
AU  - Jovanović, Aleksandar
AU  - Dimić, Nemanja
AU  - Catić Ðorđević, Aleksandra
AU  - Tadić, Ivana
AU  - Milošević-Georgiev, Andrijana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5492
AB  - Background Lower urinary tract symptoms (LUTS) significantly affect the quality of life of men, with a prevalence of 60% to 84%, which increases with age. However, a relatively small percentage of affected men seek advice or treatment for their symptoms. ...
PB  - Springer
C3  - International Journal of Clinical Pharmacy
T1  - Urinary tract health in the male population in the Republic of Serbia—part I
VL  - 45
IS  - 2
SP  - 537
EP  - 537
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5492
ER  - 

@conference{
author = "Jovanović, Aleksandar and Dimić, Nemanja and Catić Ðorđević, Aleksandra and Tadić, Ivana and Milošević-Georgiev, Andrijana",
year = "2023",
abstract = "Background Lower urinary tract symptoms (LUTS) significantly affect the quality of life of men, with a prevalence of 60% to 84%, which increases with age. However, a relatively small percentage of affected men seek advice or treatment for their symptoms. ...",
publisher = "Springer",
journal = "International Journal of Clinical Pharmacy",
title = "Urinary tract health in the male population in the Republic of Serbia—part I",
volume = "45",
number = "2",
pages = "537-537",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5492"
}

Jovanović, A., Dimić, N., Catić Ðorđević, A., Tadić, I.,& Milošević-Georgiev, A.. (2023). Urinary tract health in the male population in the Republic of Serbia—part I. in International Journal of Clinical Pharmacy
Springer., 45(2), 537-537.
https://hdl.handle.net/21.15107/rcub_farfar_5492

Jovanović A, Dimić N, Catić Ðorđević A, Tadić I, Milošević-Georgiev A. Urinary tract health in the male population in the Republic of Serbia—part I. in International Journal of Clinical Pharmacy. 2023;45(2):537-537.
https://hdl.handle.net/21.15107/rcub_farfar_5492 .

Jovanović, Aleksandar, Dimić, Nemanja, Catić Ðorđević, Aleksandra, Tadić, Ivana, Milošević-Georgiev, Andrijana, "Urinary tract health in the male population in the Republic of Serbia—part I" in International Journal of Clinical Pharmacy, 45, no. 2 (2023):537-537,
https://hdl.handle.net/21.15107/rcub_farfar_5492 .

TY  - CONF
AU  - Dimić, Nemanja
AU  - Milošević-Georgiev, Andrijana
AU  - Stojkov, Svetlana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5490
AB  - Uvod: Dobrovoljno davanje krvi (DDK) igra ključnu ulogu u obezbeđivanju zaliha krvi za medicinske potrebe. Međutim, od perioda Covida svedočimo opadajućim stopama dobrovoljnih davalaca krvi. Jedna od najvažnijih tema u menadžmentu jeste motivacija, a motivacioni faktori predstavljaju sredstva koja pojedinca podstiču na delovanje ka određenom cilju. Ciljevi: (i) Proceniti iskustva i stavove studenata farmacije u vezi sa DDK; (ii) Identifikovati fizičke i psihološke prepreke koje sprečavaju, kao i motive koji pokreću studente da postanu dobrovoljni davaoci krvi; Metode: Među studentima farmacije Farmaceutskog fakulteta, Univerziteta u Beogradu sprovedena je studija preseka u 2022. godini. Namenski kreiran upitnik korišćen je za prikupljanje primarnih podataka. Rezultati: Učestvovalo je 127 ispitanika, većinom ženskog pola (81,1%). Dobrovoljnih davaoca krvi bilo je 40,2%. Pozitivan stav prema DDK imalo je 93,7%. Kao prepreke za nedavanje krvi 35,4% se izjasnilo da je to zbog medicinskih razloga, a 18,9% strah od krvi I igle. Humanost je bila ključna motivacija za DDK. Zaključak: Edukacija i promotivne aktivnosti mogu povećati motivaciju studenata farmacije za DDK. Analiza motivacije je ključna za unapređenje regrutovanja i zadržavanja dobrovoljnih davalaca krvi. Važno je kontinuirano raditi na očuvanju zaliha krvi i podizanju svesti o DDK među studentima.
AB  - Introduction: Voluntary blood donation (VBD) plays a key role in providing blood supplies for medical
needs. However, since the Covid period we are witnessing declining rates of voluntary blood donors.
One of the most important topics in management is motivation, and motivational factors are means that
encourage an individual to act towards a certain goal. Objectives: (i) Assess experiences and attitudes
of pharmacy students regarding VBD; (ii) Identify the physical and psychological obstacles that prevent,
as well as the motives that drive students to become voluntary blood donors; Methods: A cross-sectional
study was conducted among pharmacy students of the Faculty of Pharmacy, University of Belgrade in
2022. A purpose-built questionnaire was used to collect primary data. Results: 127 respondents
participated, mostly female (81.1%). There were 40.2% of voluntary blood donors. 93.7% had a positive
attitude towards DDK. As obstacles for not donating blood, 35.4% stated that it was due to medical
reasons, and 18.9% said that it was fear of blood and needles. Humanity was a key motivation for VBD.
Conclusion: Education and promotional activities can increase pharmacy students' motivation for VBD.
Analysis of motivation is key to improving the recruitment and retention of voluntary blood donors. It is
important to continuously work on preserving blood supplies and raising awareness about VBD among
students.
PB  - Visoka poslovna škola strukovnih studija „Prof. dr Radomir Bojković“, Kruševac
C3  - Zbornik radova - VII Nacionalne naučno–stručne konferencije sa međunarodnim učešćem, „Trendovi u poslovanju 2023“, 29. septembar 2023, Kruševac
T1  - Značaj motivacije za postizanje cilja: veći broj dobrovoljnih davalaca krvi
T1  - The importance of motivation for achieving goals: a greater number of voluntary blood donors
SP  - 147
EP  - 153
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5490
ER  - 

@conference{
author = "Dimić, Nemanja and Milošević-Georgiev, Andrijana and Stojkov, Svetlana",
year = "2023",
abstract = "Uvod: Dobrovoljno davanje krvi (DDK) igra ključnu ulogu u obezbeđivanju zaliha krvi za medicinske potrebe. Međutim, od perioda Covida svedočimo opadajućim stopama dobrovoljnih davalaca krvi. Jedna od najvažnijih tema u menadžmentu jeste motivacija, a motivacioni faktori predstavljaju sredstva koja pojedinca podstiču na delovanje ka određenom cilju. Ciljevi: (i) Proceniti iskustva i stavove studenata farmacije u vezi sa DDK; (ii) Identifikovati fizičke i psihološke prepreke koje sprečavaju, kao i motive koji pokreću studente da postanu dobrovoljni davaoci krvi; Metode: Među studentima farmacije Farmaceutskog fakulteta, Univerziteta u Beogradu sprovedena je studija preseka u 2022. godini. Namenski kreiran upitnik korišćen je za prikupljanje primarnih podataka. Rezultati: Učestvovalo je 127 ispitanika, većinom ženskog pola (81,1%). Dobrovoljnih davaoca krvi bilo je 40,2%. Pozitivan stav prema DDK imalo je 93,7%. Kao prepreke za nedavanje krvi 35,4% se izjasnilo da je to zbog medicinskih razloga, a 18,9% strah od krvi I igle. Humanost je bila ključna motivacija za DDK. Zaključak: Edukacija i promotivne aktivnosti mogu povećati motivaciju studenata farmacije za DDK. Analiza motivacije je ključna za unapređenje regrutovanja i zadržavanja dobrovoljnih davalaca krvi. Važno je kontinuirano raditi na očuvanju zaliha krvi i podizanju svesti o DDK među studentima., Introduction: Voluntary blood donation (VBD) plays a key role in providing blood supplies for medical
needs. However, since the Covid period we are witnessing declining rates of voluntary blood donors.
One of the most important topics in management is motivation, and motivational factors are means that
encourage an individual to act towards a certain goal. Objectives: (i) Assess experiences and attitudes
of pharmacy students regarding VBD; (ii) Identify the physical and psychological obstacles that prevent,
as well as the motives that drive students to become voluntary blood donors; Methods: A cross-sectional
study was conducted among pharmacy students of the Faculty of Pharmacy, University of Belgrade in
2022. A purpose-built questionnaire was used to collect primary data. Results: 127 respondents
participated, mostly female (81.1%). There were 40.2% of voluntary blood donors. 93.7% had a positive
attitude towards DDK. As obstacles for not donating blood, 35.4% stated that it was due to medical
reasons, and 18.9% said that it was fear of blood and needles. Humanity was a key motivation for VBD.
Conclusion: Education and promotional activities can increase pharmacy students' motivation for VBD.
Analysis of motivation is key to improving the recruitment and retention of voluntary blood donors. It is
important to continuously work on preserving blood supplies and raising awareness about VBD among
students.",
publisher = "Visoka poslovna škola strukovnih studija „Prof. dr Radomir Bojković“, Kruševac",
journal = "Zbornik radova - VII Nacionalne naučno–stručne konferencije sa međunarodnim učešćem, „Trendovi u poslovanju 2023“, 29. septembar 2023, Kruševac",
title = "Značaj motivacije za postizanje cilja: veći broj dobrovoljnih davalaca krvi, The importance of motivation for achieving goals: a greater number of voluntary blood donors",
pages = "147-153",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5490"
}

Dimić, N., Milošević-Georgiev, A.,& Stojkov, S.. (2023). Značaj motivacije za postizanje cilja: veći broj dobrovoljnih davalaca krvi. in Zbornik radova - VII Nacionalne naučno–stručne konferencije sa međunarodnim učešćem, „Trendovi u poslovanju 2023“, 29. septembar 2023, Kruševac
Visoka poslovna škola strukovnih studija „Prof. dr Radomir Bojković“, Kruševac., 147-153.
https://hdl.handle.net/21.15107/rcub_farfar_5490

Dimić N, Milošević-Georgiev A, Stojkov S. Značaj motivacije za postizanje cilja: veći broj dobrovoljnih davalaca krvi. in Zbornik radova - VII Nacionalne naučno–stručne konferencije sa međunarodnim učešćem, „Trendovi u poslovanju 2023“, 29. septembar 2023, Kruševac. 2023;:147-153.
https://hdl.handle.net/21.15107/rcub_farfar_5490 .

Dimić, Nemanja, Milošević-Georgiev, Andrijana, Stojkov, Svetlana, "Značaj motivacije za postizanje cilja: veći broj dobrovoljnih davalaca krvi" in Zbornik radova - VII Nacionalne naučno–stručne konferencije sa međunarodnim učešćem, „Trendovi u poslovanju 2023“, 29. septembar 2023, Kruševac (2023):147-153,
https://hdl.handle.net/21.15107/rcub_farfar_5490 .

TY  - JOUR
AU  - Belić, Milica
AU  - Sopić, Miron
AU  - Roksandić-Milenković, Marina
AU  - Ćeriman, Vesna
AU  - Guzonjić, Azra
AU  - Vukašinović, Aleksandra
AU  - Ostanek, Barbara
AU  - Dimić, Nemanja
AU  - Jovanović, Dragana
AU  - Kotur-Stevuljević, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5387
AB  - Lung cancer (LC) is the second most common malignancy and leading cause of cancer death. The potential "culprit" for local and systemic telomere shortening in LC patients is oxidative stress. We investigated the correlation between the peripheral blood leukocyte (PBL) telomere length (TL) and the presence/severity of LC and oxidative stress, and its usefulness as LC diagnostic marker. PBL TL was measured in 89 LC patients and 83 healthy subjects using the modified Cawthon RTq-PCR method. The relative PBL TL, found to be a potential diagnostic marker for LC with very good accuracy (P < 0.001), was significantly shorter in patients compared to the control group (CG) (P < 0.001). Significantly shorter telomeres were found in patients with LC TNM stage IV than in patients with stages I-III (P = 0.014), in patients without therapy compared to those on therapy (P = 0.008), and in patients with partial response and stable/progressive disease compared to those with complete response (P = 0.039). The total oxidant status (TOS), advanced oxidation protein products (AOPP), prooxidant-antioxidant balance (PAB) and C-reactive protein (CRP) were significantly higher in patients compared to CG (P < 0.001) and correlated negatively with TL in both patients and CG (P < 0.001). PCA showed a relation between PAB and TL, and between the EGFR status and TL. Oxidative stress and PBL telomere shortening are probably associated with LC development and progression.
PB  - Charles University, Czech Republic
T2  - Folia biologica
T1  - Correlation of Short Leukocyte Telomeres and Oxidative
Stress with the Presence and Severity of Lung Cancer
Explored by Principal Component Analysis
VL  - 69
IS  - 2
SP  - 59
EP  - 68
DO  - 10.14712/fb2023069020059
ER  - 

@article{
author = "Belić, Milica and Sopić, Miron and Roksandić-Milenković, Marina and Ćeriman, Vesna and Guzonjić, Azra and Vukašinović, Aleksandra and Ostanek, Barbara and Dimić, Nemanja and Jovanović, Dragana and Kotur-Stevuljević, Jelena",
year = "2023",
abstract = "Lung cancer (LC) is the second most common malignancy and leading cause of cancer death. The potential "culprit" for local and systemic telomere shortening in LC patients is oxidative stress. We investigated the correlation between the peripheral blood leukocyte (PBL) telomere length (TL) and the presence/severity of LC and oxidative stress, and its usefulness as LC diagnostic marker. PBL TL was measured in 89 LC patients and 83 healthy subjects using the modified Cawthon RTq-PCR method. The relative PBL TL, found to be a potential diagnostic marker for LC with very good accuracy (P < 0.001), was significantly shorter in patients compared to the control group (CG) (P < 0.001). Significantly shorter telomeres were found in patients with LC TNM stage IV than in patients with stages I-III (P = 0.014), in patients without therapy compared to those on therapy (P = 0.008), and in patients with partial response and stable/progressive disease compared to those with complete response (P = 0.039). The total oxidant status (TOS), advanced oxidation protein products (AOPP), prooxidant-antioxidant balance (PAB) and C-reactive protein (CRP) were significantly higher in patients compared to CG (P < 0.001) and correlated negatively with TL in both patients and CG (P < 0.001). PCA showed a relation between PAB and TL, and between the EGFR status and TL. Oxidative stress and PBL telomere shortening are probably associated with LC development and progression.",
publisher = "Charles University, Czech Republic",
journal = "Folia biologica",
title = "Correlation of Short Leukocyte Telomeres and Oxidative
Stress with the Presence and Severity of Lung Cancer
Explored by Principal Component Analysis",
volume = "69",
number = "2",
pages = "59-68",
doi = "10.14712/fb2023069020059"
}

Belić, M., Sopić, M., Roksandić-Milenković, M., Ćeriman, V., Guzonjić, A., Vukašinović, A., Ostanek, B., Dimić, N., Jovanović, D.,& Kotur-Stevuljević, J.. (2023). Correlation of Short Leukocyte Telomeres and Oxidative
Stress with the Presence and Severity of Lung Cancer
Explored by Principal Component Analysis. in Folia biologica
Charles University, Czech Republic., 69(2), 59-68.
https://doi.org/10.14712/fb2023069020059

Belić M, Sopić M, Roksandić-Milenković M, Ćeriman V, Guzonjić A, Vukašinović A, Ostanek B, Dimić N, Jovanović D, Kotur-Stevuljević J. Correlation of Short Leukocyte Telomeres and Oxidative
Stress with the Presence and Severity of Lung Cancer
Explored by Principal Component Analysis. in Folia biologica. 2023;69(2):59-68.
doi:10.14712/fb2023069020059 .

Belić, Milica, Sopić, Miron, Roksandić-Milenković, Marina, Ćeriman, Vesna, Guzonjić, Azra, Vukašinović, Aleksandra, Ostanek, Barbara, Dimić, Nemanja, Jovanović, Dragana, Kotur-Stevuljević, Jelena, "Correlation of Short Leukocyte Telomeres and Oxidative
Stress with the Presence and Severity of Lung Cancer
Explored by Principal Component Analysis" in Folia biologica, 69, no. 2 (2023):59-68,
https://doi.org/10.14712/fb2023069020059 . .

TY  - CONF
AU  - Guzonjić, Azra
AU  - Roksandić Milenković, Marina
AU  - Dimić, Dejan
AU  - Dimić, Nemanja
AU  - Timotijević, Ljiljana
AU  - Sopić, Miron
AU  - Vekić, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4510
AB  - The pathogenesis of the COVID-19 infection caused by the SARS-CoV-2 coronavirus is
the subject of active research worldwide. As a complex disease, it is suspected that oxidative
stress plays a role in its pathogenesis and contributes to the progressive shortening of
telomeres. Patients aged 25–84 years (n=31) were monitored at the time of diagnosis, as
well as at control on the 14th and 21st days. Redox status parameters were determined: total
oxidant status (TOS), superoxide anion radical (O2.-), prooxidant-antioxidant balance (PAB),
advanced protein oxidation products (AOPP), malondialdehyde (MDA), and ischemia-
modified albumin (IMA) as prooxidants and total antioxidant status (TAS), superoxide-
dismutase (SOD) and paraoxonase 1 (PON1) enzyme activity, total antioxidant and total
oxidant status ratio (TAS/TOS), and total sulfhydryl groups (SHG) as antioxidants. Patients
have the shortest telomeres at diagnosis and their length increases during recovery. A
statistically significant difference in rTL was shown in patients at the time of diagnosis and
after 21 days (p=0.008). rTL has a statistically significant negative correlation with SHG in
patients at the time of diagnosis (ρ=-0.386, p=0.038), as well as in patients after 14 days (ρ =-
0.389, p=0.037). After 21 days, a statistically significant positive correlation was shown
between rTL and SOD (ρ =0.381, p=0.046). The obtained results indicate progressive
shortening of telomeres caused by COVID-19 infection, impaired redox status, as well as the
change of these parameters during recovery, which confirms the link between oxidative
stress and rTL, as well as the participation of these processes in the pathogenesis of COVID-
19.
AB  - Patogeneza COVID-19 infekcije izazvane koronavirusom SARS-CoV-2 je predmet
aktivnog istraživanja širom sveta. Kako je u pitanju složena bolest, smatra se da i u njenoj
patogenezi leži oksidativni stres, koji doprinosi progesivnom skraćivanju telomera. Pacijenti
starosti 25-84 godina (n=31) praćeni su u trenutku postavljanja dijagnoze, kao i na kontroli
14. i 21. dana. Parametri redoks statusa određivani su iz seruma ili plazme odgovarajućim
spektrofotometrijskim metodama, dok je iz leukocita periferne krvi merena relativna dužina
telomera (rTL) pomoću qPCR metode. Od parametara oksidativnog statusa određivani su:
totalni oksidantni status (TOS), superoksidni anjon radikal (O2.- ), prooksidantno-
antioksidantni balans (PAB), uznapredovali produkti oksidacije proteina (AOPP),
malondialdehid (MDA), ishemijom modifikovan albumin (IMA). Kao parametri
antioksidativne zaštite određivani su: totalni antioksidantni status (TAS), aktivnost enzima
superoksid-dismutaze (SOD) i paraoksonaze 1 (PON1), odnos totalnog antioksidantnog i
totalnog oksidantnog statusa (TAS/TOS), kao i ukupne sulfhidrilne grupe (SHG). Pacijenti u
trenutku postavljanja dijagnoze imaju najkraće telomere i njihova dužina se povećava tokom
oporavka. Pokazana je statistički značajna razlika u rTL kod pacijenata u trenutku
postavljanja dijagnoze i nakon 21 dan (p=0,008). rTL je u statistički značajnoj negativnoj
korelaciji sa SHG kod pacijenata u trenutku postavljanja dijagnoze (ρ=-0,386, p=0,038), kao i
kod pacijenata nakon 14 dana oporavka (ρ=-0,389, p=0,037). Nakon 21 dan, pokazana je
statistički značajna pozitivna korelacija između rTL i SOD (ρ=0,381, p=0,046). Dobijeni
rezultati ukazuju na progresivno skraćenje telomera izazvano COVID-19 infekcijom, narušen
redoks status, kao i na promenu ovih parametara tokom oporavka, koja potvrđuje vezu
između oksidativnog stresa i rTL, kao i učešće ovih procesa u patogenezi COVID-19.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Oxidative stress and telomere length in COVID-19 patients
T1  - Oksidativni stres i dužina telomera kod COVID‐19 pacijenata
VL  - 72
IS  - 4 suplement
SP  - S231
EP  - S232
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4510
ER  - 

@conference{
author = "Guzonjić, Azra and Roksandić Milenković, Marina and Dimić, Dejan and Dimić, Nemanja and Timotijević, Ljiljana and Sopić, Miron and Vekić, Jelena and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena",
year = "2022",
abstract = "The pathogenesis of the COVID-19 infection caused by the SARS-CoV-2 coronavirus is
the subject of active research worldwide. As a complex disease, it is suspected that oxidative
stress plays a role in its pathogenesis and contributes to the progressive shortening of
telomeres. Patients aged 25–84 years (n=31) were monitored at the time of diagnosis, as
well as at control on the 14th and 21st days. Redox status parameters were determined: total
oxidant status (TOS), superoxide anion radical (O2.-), prooxidant-antioxidant balance (PAB),
advanced protein oxidation products (AOPP), malondialdehyde (MDA), and ischemia-
modified albumin (IMA) as prooxidants and total antioxidant status (TAS), superoxide-
dismutase (SOD) and paraoxonase 1 (PON1) enzyme activity, total antioxidant and total
oxidant status ratio (TAS/TOS), and total sulfhydryl groups (SHG) as antioxidants. Patients
have the shortest telomeres at diagnosis and their length increases during recovery. A
statistically significant difference in rTL was shown in patients at the time of diagnosis and
after 21 days (p=0.008). rTL has a statistically significant negative correlation with SHG in
patients at the time of diagnosis (ρ=-0.386, p=0.038), as well as in patients after 14 days (ρ =-
0.389, p=0.037). After 21 days, a statistically significant positive correlation was shown
between rTL and SOD (ρ =0.381, p=0.046). The obtained results indicate progressive
shortening of telomeres caused by COVID-19 infection, impaired redox status, as well as the
change of these parameters during recovery, which confirms the link between oxidative
stress and rTL, as well as the participation of these processes in the pathogenesis of COVID-
19., Patogeneza COVID-19 infekcije izazvane koronavirusom SARS-CoV-2 je predmet
aktivnog istraživanja širom sveta. Kako je u pitanju složena bolest, smatra se da i u njenoj
patogenezi leži oksidativni stres, koji doprinosi progesivnom skraćivanju telomera. Pacijenti
starosti 25-84 godina (n=31) praćeni su u trenutku postavljanja dijagnoze, kao i na kontroli
14. i 21. dana. Parametri redoks statusa određivani su iz seruma ili plazme odgovarajućim
spektrofotometrijskim metodama, dok je iz leukocita periferne krvi merena relativna dužina
telomera (rTL) pomoću qPCR metode. Od parametara oksidativnog statusa određivani su:
totalni oksidantni status (TOS), superoksidni anjon radikal (O2.- ), prooksidantno-
antioksidantni balans (PAB), uznapredovali produkti oksidacije proteina (AOPP),
malondialdehid (MDA), ishemijom modifikovan albumin (IMA). Kao parametri
antioksidativne zaštite određivani su: totalni antioksidantni status (TAS), aktivnost enzima
superoksid-dismutaze (SOD) i paraoksonaze 1 (PON1), odnos totalnog antioksidantnog i
totalnog oksidantnog statusa (TAS/TOS), kao i ukupne sulfhidrilne grupe (SHG). Pacijenti u
trenutku postavljanja dijagnoze imaju najkraće telomere i njihova dužina se povećava tokom
oporavka. Pokazana je statistički značajna razlika u rTL kod pacijenata u trenutku
postavljanja dijagnoze i nakon 21 dan (p=0,008). rTL je u statistički značajnoj negativnoj
korelaciji sa SHG kod pacijenata u trenutku postavljanja dijagnoze (ρ=-0,386, p=0,038), kao i
kod pacijenata nakon 14 dana oporavka (ρ=-0,389, p=0,037). Nakon 21 dan, pokazana je
statistički značajna pozitivna korelacija između rTL i SOD (ρ=0,381, p=0,046). Dobijeni
rezultati ukazuju na progresivno skraćenje telomera izazvano COVID-19 infekcijom, narušen
redoks status, kao i na promenu ovih parametara tokom oporavka, koja potvrđuje vezu
između oksidativnog stresa i rTL, kao i učešće ovih procesa u patogenezi COVID-19.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Oxidative stress and telomere length in COVID-19 patients, Oksidativni stres i dužina telomera kod COVID‐19 pacijenata",
volume = "72",
number = "4 suplement",
pages = "S231-S232",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4510"
}

Guzonjić, A., Roksandić Milenković, M., Dimić, D., Dimić, N., Timotijević, L., Sopić, M., Vekić, J., Bogavac-Stanojević, N.,& Kotur-Stevuljević, J.. (2022). Oxidative stress and telomere length in COVID-19 patients. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S231-S232.
https://hdl.handle.net/21.15107/rcub_farfar_4510

Guzonjić A, Roksandić Milenković M, Dimić D, Dimić N, Timotijević L, Sopić M, Vekić J, Bogavac-Stanojević N, Kotur-Stevuljević J. Oxidative stress and telomere length in COVID-19 patients. in Arhiv za farmaciju. 2022;72(4 suplement):S231-S232.
https://hdl.handle.net/21.15107/rcub_farfar_4510 .

Guzonjić, Azra, Roksandić Milenković, Marina, Dimić, Dejan, Dimić, Nemanja, Timotijević, Ljiljana, Sopić, Miron, Vekić, Jelena, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, "Oxidative stress and telomere length in COVID-19 patients" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S231-S232,
https://hdl.handle.net/21.15107/rcub_farfar_4510 .

TY  - CONF
AU  - Dimić, Nemanja
AU  - Catić Ðorđević, Aleksandra
AU  - Milošević-Georgiev, Andrijana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5498
AB  - A reliable diagnostic tool used to measure the severity of symptoms of lower urinary tract disorders is the International Prostate Symptom Score questionnaire (IPSS), developed by the American Urological Association in 1992. The IPSS is available online in 53 different language variants. Twenty-seven language versions of the questionnaire have been validated in 22 published studies. The aim of the work is to examine the prevalence of lower urinary tract symptoms in men in the Republic of Serbia. The research was conducted between May and June 2022, on a sample of 207 males. The respondents were a randomly selected group over the age of 18. After the obtained results, data processing was started in the SPSS program. Most of the respondents were over 56 years old (32.4%), and according to their level of education, most of the respondents had a university education (40.1%) and high school (36.7%). To the question "How often in the last month did they get up at night to urinate?", the largest percentage of respondents answered that they never got up (26.6%). Other answers were from 1 to 5 and more, respectively 18.8%; 17.4%; 16.4%; 12.6%; 8.2%. Half of the respondents (51.2%) had intermittent urination in the last month, and 49.3% of the respondents could not delay urination in the last month. The prevalence of lower urinary tract symptoms is high in the studied population. It is necessary to increase the awareness of the general population about the importance of lower urinary tract symptoms.
AB  - Pouzdan dijagnostički alat koji se koristi za merenje težine simptoma poremećaja donjeg urinarnog trakta je upitnik Internacionalni prostatični simptom skor (IPSS). Razvijen je od strane Američke urološke asocijacije 1992. godine. IPSS je dostupan na internetu u 53 različite jezičke varijante. Dvadeset sedam jezičkih varijanti upitnika je validirano u 22 objavljene studije. Cilj rada bio je ispitati prevalencu simptoma donjeg urinarnog trakta kod muškaraca u Republici Srbiji. Istraživanje je sprovedeno tokom maja i juna, na uzorku od 207 muškaraca. Ispitanici su bili nasumično odabrana grupa muškaraca starosti preko 18 godina. Nakon dobijenih rezultata pristupilo se obradi podataka u programu SPSS. Najviše je bilo ispitanika starijih od 56 godina (32,4%), a prema nivou obrazovanja, najviše je bilo ispitanika sa fakultetskim (40,1%) i srednjim obrazovanjem (36,7%). Na pitanje „Koliko su često u poslednjih mesec dana ustajali noću radi mokrenja?“ najveći procenat ispitanika odgovorio negativno (26,6%). Ostali odgovori bili su od jedanput do pet i više, redom 18,8%; 17,4%; 16,4%; 12,6%; 8,2%. Kod polovine ispitanika (51,2%) bilo je prisutno isprekidano mokrenje poslednjih mesec dana, a 49,3% ispitanika u poslednjih mesec dana nije moglo da odloži mokrenje. Prevalenca simptoma donjih urinarnih puteva je visoka u ispitanoj populaciji. Potrebno je povećati i svest opšte populacije o značaju simptoma donjih urinarnih puteva.
PB  - Univerzitet u Nišu Medicinski fakultet
C3  - Acta Medica Medianae
T1  - The significance of determining the severity of lower urinary tract symptoms in the male population in the Republic of Serbia
T1  - Značaj određivanja težine simptoma donjih urinarnih puteva u muškoj populaciji u Republici Srbiji
VL  - 61
IS  - 3
SP  - 83
EP  - 84
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5498
ER  - 

@conference{
author = "Dimić, Nemanja and Catić Ðorđević, Aleksandra and Milošević-Georgiev, Andrijana",
year = "2022",
abstract = "A reliable diagnostic tool used to measure the severity of symptoms of lower urinary tract disorders is the International Prostate Symptom Score questionnaire (IPSS), developed by the American Urological Association in 1992. The IPSS is available online in 53 different language variants. Twenty-seven language versions of the questionnaire have been validated in 22 published studies. The aim of the work is to examine the prevalence of lower urinary tract symptoms in men in the Republic of Serbia. The research was conducted between May and June 2022, on a sample of 207 males. The respondents were a randomly selected group over the age of 18. After the obtained results, data processing was started in the SPSS program. Most of the respondents were over 56 years old (32.4%), and according to their level of education, most of the respondents had a university education (40.1%) and high school (36.7%). To the question "How often in the last month did they get up at night to urinate?", the largest percentage of respondents answered that they never got up (26.6%). Other answers were from 1 to 5 and more, respectively 18.8%; 17.4%; 16.4%; 12.6%; 8.2%. Half of the respondents (51.2%) had intermittent urination in the last month, and 49.3% of the respondents could not delay urination in the last month. The prevalence of lower urinary tract symptoms is high in the studied population. It is necessary to increase the awareness of the general population about the importance of lower urinary tract symptoms., Pouzdan dijagnostički alat koji se koristi za merenje težine simptoma poremećaja donjeg urinarnog trakta je upitnik Internacionalni prostatični simptom skor (IPSS). Razvijen je od strane Američke urološke asocijacije 1992. godine. IPSS je dostupan na internetu u 53 različite jezičke varijante. Dvadeset sedam jezičkih varijanti upitnika je validirano u 22 objavljene studije. Cilj rada bio je ispitati prevalencu simptoma donjeg urinarnog trakta kod muškaraca u Republici Srbiji. Istraživanje je sprovedeno tokom maja i juna, na uzorku od 207 muškaraca. Ispitanici su bili nasumično odabrana grupa muškaraca starosti preko 18 godina. Nakon dobijenih rezultata pristupilo se obradi podataka u programu SPSS. Najviše je bilo ispitanika starijih od 56 godina (32,4%), a prema nivou obrazovanja, najviše je bilo ispitanika sa fakultetskim (40,1%) i srednjim obrazovanjem (36,7%). Na pitanje „Koliko su često u poslednjih mesec dana ustajali noću radi mokrenja?“ najveći procenat ispitanika odgovorio negativno (26,6%). Ostali odgovori bili su od jedanput do pet i više, redom 18,8%; 17,4%; 16,4%; 12,6%; 8,2%. Kod polovine ispitanika (51,2%) bilo je prisutno isprekidano mokrenje poslednjih mesec dana, a 49,3% ispitanika u poslednjih mesec dana nije moglo da odloži mokrenje. Prevalenca simptoma donjih urinarnih puteva je visoka u ispitanoj populaciji. Potrebno je povećati i svest opšte populacije o značaju simptoma donjih urinarnih puteva.",
publisher = "Univerzitet u Nišu Medicinski fakultet",
journal = "Acta Medica Medianae",
title = "The significance of determining the severity of lower urinary tract symptoms in the male population in the Republic of Serbia, Značaj određivanja težine simptoma donjih urinarnih puteva u muškoj populaciji u Republici Srbiji",
volume = "61",
number = "3",
pages = "83-84",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5498"
}

Dimić, N., Catić Ðorđević, A.,& Milošević-Georgiev, A.. (2022). The significance of determining the severity of lower urinary tract symptoms in the male population in the Republic of Serbia. in Acta Medica Medianae
Univerzitet u Nišu Medicinski fakultet., 61(3), 83-84.
https://hdl.handle.net/21.15107/rcub_farfar_5498

Dimić N, Catić Ðorđević A, Milošević-Georgiev A. The significance of determining the severity of lower urinary tract symptoms in the male population in the Republic of Serbia. in Acta Medica Medianae. 2022;61(3):83-84.
https://hdl.handle.net/21.15107/rcub_farfar_5498 .

Dimić, Nemanja, Catić Ðorđević, Aleksandra, Milošević-Georgiev, Andrijana, "The significance of determining the severity of lower urinary tract symptoms in the male population in the Republic of Serbia" in Acta Medica Medianae, 61, no. 3 (2022):83-84,
https://hdl.handle.net/21.15107/rcub_farfar_5498 .