Čolaković, Nataša

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  • Čolaković, Nataša (4)
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Author's Bibliography

Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma

Anđelković, Milena; Buha-Đorđević, Aleksandra; Vukelić, Dragana; Baralić, Katarina; Đukić-Ćosić, Danijela; Antonijević, Biljana; Ćurčić, Marijana; Antonijević-Miljaković, Evica; Čolaković, Nataša; Aćimović, Miodrag; Bulat, Zorica

(Udruženje toksikologa Srbije, 2023)

TY  - CONF
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Čolaković, Nataša
AU  - Aćimović, Miodrag
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5509
AB  - Iako se poslednjih godina beleži pad koncentracija Cd i Pb u životnoj sredini, istraživanja nedvosmisleno
potvrđuju da i izloženost niskim dozama može dovesti do oštećenja različitih organskih sistema.
Imajući u vidu metaloestrogena svojstva, posebno činjenicu da deluju kao endokrini ometači i
oponašaju dejstvo estrogena, njihov uticaj na reprodukciju I uloga u etiologjji hormon zavisnih karcinomima se ne sme zanemariti. ...
AB  - Regardless of decreased environmental Cd and Pb levels in recent decades, research unequivocally confirms that exposure to low levels can damage numerous organs. Considering their metaloestrogen properties, especially the fact that they act as an endocrine disruptor and mimic the effects of estrogen, their potential role on the reproduction as well in the etiology of hormone related cancers must not be neglected. ...
PB  - Udruženje toksikologa Srbije
C3  - 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
T1  - Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma
T1  - Cadmium and lead as risk factors in development of hormone related cancer
SP  - 109
EP  - 110
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5509
ER  - 
@conference{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Vukelić, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević, Biljana and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Čolaković, Nataša and Aćimović, Miodrag and Bulat, Zorica",
year = "2023",
abstract = "Iako se poslednjih godina beleži pad koncentracija Cd i Pb u životnoj sredini, istraživanja nedvosmisleno
potvrđuju da i izloženost niskim dozama može dovesti do oštećenja različitih organskih sistema.
Imajući u vidu metaloestrogena svojstva, posebno činjenicu da deluju kao endokrini ometači i
oponašaju dejstvo estrogena, njihov uticaj na reprodukciju I uloga u etiologjji hormon zavisnih karcinomima se ne sme zanemariti. ..., Regardless of decreased environmental Cd and Pb levels in recent decades, research unequivocally confirms that exposure to low levels can damage numerous organs. Considering their metaloestrogen properties, especially the fact that they act as an endocrine disruptor and mimic the effects of estrogen, their potential role on the reproduction as well in the etiology of hormone related cancers must not be neglected. ...",
publisher = "Udruženje toksikologa Srbije",
journal = "13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book",
title = "Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma, Cadmium and lead as risk factors in development of hormone related cancer",
pages = "109-110",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5509"
}
Anđelković, M., Buha-Đorđević, A., Vukelić, D., Baralić, K., Đukić-Ćosić, D., Antonijević, B., Ćurčić, M., Antonijević-Miljaković, E., Čolaković, N., Aćimović, M.,& Bulat, Z.. (2023). Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book
Udruženje toksikologa Srbije., 109-110.
https://hdl.handle.net/21.15107/rcub_farfar_5509
Anđelković M, Buha-Đorđević A, Vukelić D, Baralić K, Đukić-Ćosić D, Antonijević B, Ćurčić M, Antonijević-Miljaković E, Čolaković N, Aćimović M, Bulat Z. Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma. in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book. 2023;:109-110.
https://hdl.handle.net/21.15107/rcub_farfar_5509 .
Anđelković, Milena, Buha-Đorđević, Aleksandra, Vukelić, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević, Biljana, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Čolaković, Nataša, Aćimović, Miodrag, Bulat, Zorica, "Kadmijum i olovo kao faktori rizika za nastanak hormon zavisnih karcinoma" in 13th international congress of the Serbian society of toxicology & 1st toxSEE regional conference, 10-12 May, 2023, Belgrade, Abstract Book (2023):109-110,
https://hdl.handle.net/21.15107/rcub_farfar_5509 .

Possible role of lead in breast cancer — a case-control study

Anđelković, Milena; Buha-Đorđević, Aleksandra; Javorac, Dragana; Baralić, Katarina; Đukić-Ćosić, Danijela; Repić, Aleksandra; Zeljković, Aleksandra; Vekić, Jelena; Čolaković, Nataša; Bulat, Zorica

(Springer Nature, 2022)

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Repić, Aleksandra
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Čolaković, Nataša
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4103
AB  - Numerous risk factors have been associated with breast cancer (BC), exposure to metalloestrogen, like lead, being such. Since lead involvement in BC is still equivocal, we focused on lead levels in three compartments of BC patients, blood, healthy, and malignant tissues. Also, as the cholesterol role in cancer development was recognized at the beginning of the twentieth century and led to involvement in lipid profile impairment, we further extend our research on lipid profile and enzymes responsible for maintaining lipid balance in BC patients. Fifty-five women diagnosed with BC were enrolled in the study. Forty-one healthy women represented the control group. Lead levels in blood, healthy surrounding and malignant tissue, and lipid profile parameters in serum, were determined. Higher lead levels were obtained in surrounding healthy tissue samples compared to cancerous tissue samples, while blood lead levels of BC women did not differ significantly from the control group. The altered lipid profile scheme in women diagnosed with breast cancer contained significantly higher triglycerides levels (P < 0.001). Moreover, logistic regression analysis revealed triglycerides as a significant predictor of BC (OR = 2.6; P < 0.01). Although statistical significance was missing for lower paraoxonase-1 (PON-1) activities observed in BC women, multivariate logistic regression singled out PON-1 activities as significant BC predictors. The result of the present study further indicated oxidative status imbalance and tissue levels bioelements perturbation. Obtained results in the present study propose possible lead involvement in BC onset accompanied with bioelements redistribution and oxidative stress occurrence.
PB  - Springer Nature
T2  - Environmental Science and Pollution Research
T1  - Possible role of lead in breast cancer — a case-control study
VL  - 29
SP  - 65211
EP  - 65221
DO  - 10.1007/s11356-022-20439-z
ER  - 
@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Repić, Aleksandra and Zeljković, Aleksandra and Vekić, Jelena and Čolaković, Nataša and Bulat, Zorica",
year = "2022",
abstract = "Numerous risk factors have been associated with breast cancer (BC), exposure to metalloestrogen, like lead, being such. Since lead involvement in BC is still equivocal, we focused on lead levels in three compartments of BC patients, blood, healthy, and malignant tissues. Also, as the cholesterol role in cancer development was recognized at the beginning of the twentieth century and led to involvement in lipid profile impairment, we further extend our research on lipid profile and enzymes responsible for maintaining lipid balance in BC patients. Fifty-five women diagnosed with BC were enrolled in the study. Forty-one healthy women represented the control group. Lead levels in blood, healthy surrounding and malignant tissue, and lipid profile parameters in serum, were determined. Higher lead levels were obtained in surrounding healthy tissue samples compared to cancerous tissue samples, while blood lead levels of BC women did not differ significantly from the control group. The altered lipid profile scheme in women diagnosed with breast cancer contained significantly higher triglycerides levels (P < 0.001). Moreover, logistic regression analysis revealed triglycerides as a significant predictor of BC (OR = 2.6; P < 0.01). Although statistical significance was missing for lower paraoxonase-1 (PON-1) activities observed in BC women, multivariate logistic regression singled out PON-1 activities as significant BC predictors. The result of the present study further indicated oxidative status imbalance and tissue levels bioelements perturbation. Obtained results in the present study propose possible lead involvement in BC onset accompanied with bioelements redistribution and oxidative stress occurrence.",
publisher = "Springer Nature",
journal = "Environmental Science and Pollution Research",
title = "Possible role of lead in breast cancer — a case-control study",
volume = "29",
pages = "65211-65221",
doi = "10.1007/s11356-022-20439-z"
}
Anđelković, M., Buha-Đorđević, A., Javorac, D., Baralić, K., Đukić-Ćosić, D., Repić, A., Zeljković, A., Vekić, J., Čolaković, N.,& Bulat, Z.. (2022). Possible role of lead in breast cancer — a case-control study. in Environmental Science and Pollution Research
Springer Nature., 29, 65211-65221.
https://doi.org/10.1007/s11356-022-20439-z
Anđelković M, Buha-Đorđević A, Javorac D, Baralić K, Đukić-Ćosić D, Repić A, Zeljković A, Vekić J, Čolaković N, Bulat Z. Possible role of lead in breast cancer — a case-control study. in Environmental Science and Pollution Research. 2022;29:65211-65221.
doi:10.1007/s11356-022-20439-z .
Anđelković, Milena, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Repić, Aleksandra, Zeljković, Aleksandra, Vekić, Jelena, Čolaković, Nataša, Bulat, Zorica, "Possible role of lead in breast cancer — a case-control study" in Environmental Science and Pollution Research, 29 (2022):65211-65221,
https://doi.org/10.1007/s11356-022-20439-z . .
1
3
3

Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?

Anđelković, Milena; Buha-Đorđević, Aleksandra; Javorac, Dragana; Baralić, Katarina; Đukić-Ćosić, Danijela; Antonijević, Biljana; Ćurčić, Marijana; Antonijević-Miljaković, Evica; Čolaković, Nataša; Aćimović, Miodrag; Bulat, Zorica

(Savez farmaceutskih udruženja Srbije (SFUS), 2022)

TY  - CONF
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Čolaković, Nataša
AU  - Aćimović, Miodrag
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4497
AB  - The endocrine potential of Cd and Pb, an important mechanism of their toxicity, has
been established in certain hormone-dependent cancers (1,2). This study aimed to
determine Cd and Pb levels in blood, tumor and healthy surrounding tissue of patients with
breast, prostate and testis cancer and investigate the correlation of Cd and Pb with sex
hormone levels in the patient's blood. The study involved 55 breast, 41 prostate and 52 testis
cancer patients, while healthy women (41) and men (61) represented control groups.
Electrothermal atomic absorption spectrophotometry was used for Cd and Pb levels
determination. Significantly higher Cd levels, i.e. lower Pb in tumor tissue compared to the
healthy surrounding tissue were found in patients with breast cancer. A positive correlation
was confirmed between Cd levels in the changed tissue and both human gonadotropins, and
a negative correlation with estradiol, as well between Pb in tumor tissue and testosterone
levels. Patients with prostate and testis cancer were characterized by significantly higher
blood Cd levels compared to healthy subjects. Furthermore, significant Cd and Pb tumor
tissue accumulation was shown in prostate and testis cancer patients. A significant positive
correlation was found between blood Cd and estradiol levels in patients with prostate
cancer. The study highlighted higher Cd level as a significant predictor of cancer, and
confirmed impaired sex hormone homeostasis as pivotal mechanism of toxicity underlying
the toxic effects of Cd and Pb in patients with breast, prostate and testis cancer.
AB  - Endokrini potencijal kadmijuma (Cd) i olova (Pb), kao važan mehanizam toksičnosti
oba metala, potvrđen je kod određenih hormon-zavisnih karcinoma (1,2). Ova studija je
imala za cilj da utvrdi koncentracije Cd i Pb u krvi, tumorskom i okolnom zdravom tkivu
pacijenata sa karcinomom dojke, prostate i testisa i ispita korelaciju Cd i Pb sa nivoom polnih
hormona u krvi pacijenata. Obuhvatila je 55 pacijentkinja sa karcinomom dojke, 41 pacijenta
sa karcinomom prostate i 52 pacijenta sa karcinomom testisa, dok su u kontrolnu grupu bile
uključene zdrave žene (41) i zdravi muškarci (61). Koncentracije Cd i Pb su analizirane
elektrotermalnom atomskom apsorpcionom spektrofotometrijom. Značajno više
koncentracije Cd, odnosno niže Pb u tumorskom u odnosu na okolno zdravo tkivo utvrđene
su kod pacijentkinja sa karcinomom dojke. Pozitivna korelacija je potvrđena između
koncentracija Cd u tkivu izmenjene strukture i oba humana gonadotropina, a negativna sa
estradiolom, te između Pb u tumorskom tkivu i testosterona. Pacijente sa karcinomom
prostate i testisa karakterisale su značajno više koncentracije Cd u krvi u odnosu na zdrave
ispitanike, a pokazana je i značajna akumulacija Cd i Pb u tumorskom tkivu prostate i testisa.
Značajna pozitivna korelacija utvrđena je između koncentracije Cd i estradiola u krvi kod
pacijenata sa karcinom prostate. Studija je pokazala da su više koncentracije Cd značajan
prediktor za nastanak karcinoma i potvrdilanarušenu homeostazu polnih hormona kao
važan mehanizam toksičnosti koji se nalazi u osnovi toksičnih efekata Cd i Pb kod obolelih od
karcinoma dojke, prostate i testisa.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?
T1  - Narušena homeostaza polnih hormona kod pacijenata sa karcinom dojke, prostate i testisa: koja je uloga kadmijuma i olova
VL  - 72
IS  - 4 suplement
SP  - S211
EP  - S212
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4497
ER  - 
@conference{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević, Biljana and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Čolaković, Nataša and Aćimović, Miodrag and Bulat, Zorica",
year = "2022",
abstract = "The endocrine potential of Cd and Pb, an important mechanism of their toxicity, has
been established in certain hormone-dependent cancers (1,2). This study aimed to
determine Cd and Pb levels in blood, tumor and healthy surrounding tissue of patients with
breast, prostate and testis cancer and investigate the correlation of Cd and Pb with sex
hormone levels in the patient's blood. The study involved 55 breast, 41 prostate and 52 testis
cancer patients, while healthy women (41) and men (61) represented control groups.
Electrothermal atomic absorption spectrophotometry was used for Cd and Pb levels
determination. Significantly higher Cd levels, i.e. lower Pb in tumor tissue compared to the
healthy surrounding tissue were found in patients with breast cancer. A positive correlation
was confirmed between Cd levels in the changed tissue and both human gonadotropins, and
a negative correlation with estradiol, as well between Pb in tumor tissue and testosterone
levels. Patients with prostate and testis cancer were characterized by significantly higher
blood Cd levels compared to healthy subjects. Furthermore, significant Cd and Pb tumor
tissue accumulation was shown in prostate and testis cancer patients. A significant positive
correlation was found between blood Cd and estradiol levels in patients with prostate
cancer. The study highlighted higher Cd level as a significant predictor of cancer, and
confirmed impaired sex hormone homeostasis as pivotal mechanism of toxicity underlying
the toxic effects of Cd and Pb in patients with breast, prostate and testis cancer., Endokrini potencijal kadmijuma (Cd) i olova (Pb), kao važan mehanizam toksičnosti
oba metala, potvrđen je kod određenih hormon-zavisnih karcinoma (1,2). Ova studija je
imala za cilj da utvrdi koncentracije Cd i Pb u krvi, tumorskom i okolnom zdravom tkivu
pacijenata sa karcinomom dojke, prostate i testisa i ispita korelaciju Cd i Pb sa nivoom polnih
hormona u krvi pacijenata. Obuhvatila je 55 pacijentkinja sa karcinomom dojke, 41 pacijenta
sa karcinomom prostate i 52 pacijenta sa karcinomom testisa, dok su u kontrolnu grupu bile
uključene zdrave žene (41) i zdravi muškarci (61). Koncentracije Cd i Pb su analizirane
elektrotermalnom atomskom apsorpcionom spektrofotometrijom. Značajno više
koncentracije Cd, odnosno niže Pb u tumorskom u odnosu na okolno zdravo tkivo utvrđene
su kod pacijentkinja sa karcinomom dojke. Pozitivna korelacija je potvrđena između
koncentracija Cd u tkivu izmenjene strukture i oba humana gonadotropina, a negativna sa
estradiolom, te između Pb u tumorskom tkivu i testosterona. Pacijente sa karcinomom
prostate i testisa karakterisale su značajno više koncentracije Cd u krvi u odnosu na zdrave
ispitanike, a pokazana je i značajna akumulacija Cd i Pb u tumorskom tkivu prostate i testisa.
Značajna pozitivna korelacija utvrđena je između koncentracije Cd i estradiola u krvi kod
pacijenata sa karcinom prostate. Studija je pokazala da su više koncentracije Cd značajan
prediktor za nastanak karcinoma i potvrdilanarušenu homeostazu polnih hormona kao
važan mehanizam toksičnosti koji se nalazi u osnovi toksičnih efekata Cd i Pb kod obolelih od
karcinoma dojke, prostate i testisa.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?, Narušena homeostaza polnih hormona kod pacijenata sa karcinom dojke, prostate i testisa: koja je uloga kadmijuma i olova",
volume = "72",
number = "4 suplement",
pages = "S211-S212",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4497"
}
Anđelković, M., Buha-Đorđević, A., Javorac, D., Baralić, K., Đukić-Ćosić, D., Antonijević, B., Ćurčić, M., Antonijević-Miljaković, E., Čolaković, N., Aćimović, M.,& Bulat, Z.. (2022). Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S211-S212.
https://hdl.handle.net/21.15107/rcub_farfar_4497
Anđelković M, Buha-Đorđević A, Javorac D, Baralić K, Đukić-Ćosić D, Antonijević B, Ćurčić M, Antonijević-Miljaković E, Čolaković N, Aćimović M, Bulat Z. Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?. in Arhiv za farmaciju. 2022;72(4 suplement):S211-S212.
https://hdl.handle.net/21.15107/rcub_farfar_4497 .
Anđelković, Milena, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević, Biljana, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Čolaković, Nataša, Aćimović, Miodrag, Bulat, Zorica, "Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S211-S212,
https://hdl.handle.net/21.15107/rcub_farfar_4497 .

Cadmium tissue level in women diagnosed with breast cancer – A case control study

Anđelković, Milena; Buha-Đorđević, Aleksandra; Antonijević-Miljaković, Evica; Javorac, Dragana; Čolaković, Nataša; Oprić, Svetlana; Petričević, Simona; Granić, Miroslav; Kotur-Stevuljević, Jelena; Antonijević, Biljana; Bulat, Zorica

(Elsevier, 2021)

TY  - JOUR
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Javorac, Dragana
AU  - Čolaković, Nataša
AU  - Oprić, Svetlana
AU  - Petričević, Simona
AU  - Granić, Miroslav
AU  - Kotur-Stevuljević, Jelena
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3915
AB  - Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.
PB  - Elsevier
T2  - Environmental Research
T1  - Cadmium tissue level in women diagnosed with breast cancer – A case control study
VL  - 199
DO  - 10.1016/j.envres.2021.111300
ER  - 
@article{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Javorac, Dragana and Čolaković, Nataša and Oprić, Svetlana and Petričević, Simona and Granić, Miroslav and Kotur-Stevuljević, Jelena and Antonijević, Biljana and Bulat, Zorica",
year = "2021",
abstract = "Breast cancer is at the forefront of female malignancy and the leading cause of cancer death among women. Gender, age, hormone therapy, smoking, exposure to endocrine disruptors and family history are significant breast cancer risk factors according to epidemiological data. Considering metalloestrogenic Cd property and a plethora of research work on hormone involvement in breast cancer the study aimed to determine Cd concentration in three compartments of breast cancer patients in relation to their blood hormone status. Further, as oxidative stress is a critical mechanism of Cd toxicity, the objective of this study was to determine potential changes in oxidative status homeostasis. The study enrolled 55 patients with breast cancer diagnosis and 41 healthy women with benign breast changes. Concentration of Cd was determined using graphite furnace atomic absorption spectrometry. Cadmium concentration in tumor tissue was significantly higher than control and almost four times higher than Cd concentration in the healthy surrounding tissue. Strong positive correlation was observed between Cd concentrations in changed breast tissue and FSH and LH levels, while the correlation was negative with estradiol level. Cancer patients had significantly increased blood total antioxidative status while total oxidative status did not significantly differ between study groups. The study revealed Cd implication in breast cancer onset following a significant odd ratio for Cd levels in changed tissue samples. Moreover, presented data confirmed sex hormone and oxidative status imbalance caused by Cd presence, closely related to cancer development.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "Cadmium tissue level in women diagnosed with breast cancer – A case control study",
volume = "199",
doi = "10.1016/j.envres.2021.111300"
}
Anđelković, M., Buha-Đorđević, A., Antonijević-Miljaković, E., Javorac, D., Čolaković, N., Oprić, S., Petričević, S., Granić, M., Kotur-Stevuljević, J., Antonijević, B.,& Bulat, Z.. (2021). Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research
Elsevier., 199.
https://doi.org/10.1016/j.envres.2021.111300
Anđelković M, Buha-Đorđević A, Antonijević-Miljaković E, Javorac D, Čolaković N, Oprić S, Petričević S, Granić M, Kotur-Stevuljević J, Antonijević B, Bulat Z. Cadmium tissue level in women diagnosed with breast cancer – A case control study. in Environmental Research. 2021;199.
doi:10.1016/j.envres.2021.111300 .
Anđelković, Milena, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Javorac, Dragana, Čolaković, Nataša, Oprić, Svetlana, Petričević, Simona, Granić, Miroslav, Kotur-Stevuljević, Jelena, Antonijević, Biljana, Bulat, Zorica, "Cadmium tissue level in women diagnosed with breast cancer – A case control study" in Environmental Research, 199 (2021),
https://doi.org/10.1016/j.envres.2021.111300 . .
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