TY  - JOUR
AU  - Vukašinović, Aleksandra
AU  - Ostanek, Barbara
AU  - Klisić, Aleksandra
AU  - Kafedžić, Srđan
AU  - Zdravković, Marija
AU  - Ilić, Ivan
AU  - Sopić, Miron
AU  - Hinić, Saša
AU  - Stefanović, Milica
AU  - Memon, Lidija
AU  - Gaković, Branka
AU  - Bogavac-Stanojević, Nataša
AU  - Spasojević-Kalimanovska, Vesna
AU  - Marc, Janja
AU  - Nešković, Aleksandar
AU  - Kotur-Stevuljević, Jelena
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4677
AB  - Introduction: Telomeres are protective chromosomal ends. Short telomeres are a proven biomarker of biological aging. We aimed to find an association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction. Furthermore, association of the telomere-telomerase system with oxidative stress markers (as common risk factors for coronary artery disease (CAD)) was tested. Material and methods: Patients were selected from the patients admitted to the intensive care unit with acute myocardial infarction with ST-segment elevation (STEMI), with the following inclusion criteria – STEMI patients between 18 and 80 years old of both genders and candidates for primary percutaneous coronary intervention, with infarction pain present for a maximum of 12 h. In all the patients leukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated. Results: Patients were divided into different groups: with stable angina pectoris (AP) (n = 22), acute myocardial infarction with: STEMI (n = 93), non-obstructive coronary arteries (MINOCA) (n = 7), blood vessel rupture (n = 6) at three time points, and compared to the group of 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group (AP = 0.373 (0.355–0.386), STEMI = 0.375 (0.349–0.395), MINOCA = 0.391 (0.366–0.401), blood vessel rupture = 0.360 (0.352–0.385) vs. CG = 0.069 (0.061–0.081), p < 0.001), while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture groups compared to the control group (STEMI = 1.179 (0.931–1.376), MINOCA = 1.026 (0.951–1.070), blood vessel rupture = 1.089 (0.842–1.173) vs. CG = 1.329 (1.096–1.624), p = 0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to the control group and AP patients (5.83 (4.55–7.54) and 10.28 (9.19–10.72) vs. 4.94 (3.29–6.18) and 4.18 (2.58–4.86), p < 0.001). Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to the peripheral blood leukocytes in the same patients (1.25 (1.01–1.84) vs. 1.18 (0.909–1.516), p = 0.036; and 0.366 (0.367–0.379) vs. 0.366 (0.367–0.379), p < 0.001, respectively). In addition, telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from healthy persons. Conclusions: Leukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.
PB  - Termedia Publishing House Ltd.
T2  - Archives of Medical Science
T1  - Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress
VL  - 19
IS  - 2
SP  - 313
EP  - 323
DO  - 10.5114/aoms/136074
ER  - 

@article{
author = "Vukašinović, Aleksandra and Ostanek, Barbara and Klisić, Aleksandra and Kafedžić, Srđan and Zdravković, Marija and Ilić, Ivan and Sopić, Miron and Hinić, Saša and Stefanović, Milica and Memon, Lidija and Gaković, Branka and Bogavac-Stanojević, Nataša and Spasojević-Kalimanovska, Vesna and Marc, Janja and Nešković, Aleksandar and Kotur-Stevuljević, Jelena",
year = "2023",
abstract = "Introduction: Telomeres are protective chromosomal ends. Short telomeres are a proven biomarker of biological aging. We aimed to find an association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction. Furthermore, association of the telomere-telomerase system with oxidative stress markers (as common risk factors for coronary artery disease (CAD)) was tested. Material and methods: Patients were selected from the patients admitted to the intensive care unit with acute myocardial infarction with ST-segment elevation (STEMI), with the following inclusion criteria – STEMI patients between 18 and 80 years old of both genders and candidates for primary percutaneous coronary intervention, with infarction pain present for a maximum of 12 h. In all the patients leukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated. Results: Patients were divided into different groups: with stable angina pectoris (AP) (n = 22), acute myocardial infarction with: STEMI (n = 93), non-obstructive coronary arteries (MINOCA) (n = 7), blood vessel rupture (n = 6) at three time points, and compared to the group of 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group (AP = 0.373 (0.355–0.386), STEMI = 0.375 (0.349–0.395), MINOCA = 0.391 (0.366–0.401), blood vessel rupture = 0.360 (0.352–0.385) vs. CG = 0.069 (0.061–0.081), p < 0.001), while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture groups compared to the control group (STEMI = 1.179 (0.931–1.376), MINOCA = 1.026 (0.951–1.070), blood vessel rupture = 1.089 (0.842–1.173) vs. CG = 1.329 (1.096–1.624), p = 0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to the control group and AP patients (5.83 (4.55–7.54) and 10.28 (9.19–10.72) vs. 4.94 (3.29–6.18) and 4.18 (2.58–4.86), p < 0.001). Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to the peripheral blood leukocytes in the same patients (1.25 (1.01–1.84) vs. 1.18 (0.909–1.516), p = 0.036; and 0.366 (0.367–0.379) vs. 0.366 (0.367–0.379), p < 0.001, respectively). In addition, telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from healthy persons. Conclusions: Leukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.",
publisher = "Termedia Publishing House Ltd.",
journal = "Archives of Medical Science",
title = "Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress",
volume = "19",
number = "2",
pages = "313-323",
doi = "10.5114/aoms/136074"
}

Vukašinović, A., Ostanek, B., Klisić, A., Kafedžić, S., Zdravković, M., Ilić, I., Sopić, M., Hinić, S., Stefanović, M., Memon, L., Gaković, B., Bogavac-Stanojević, N., Spasojević-Kalimanovska, V., Marc, J., Nešković, A.,& Kotur-Stevuljević, J.. (2023). Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress. in Archives of Medical Science
Termedia Publishing House Ltd.., 19(2), 313-323.
https://doi.org/10.5114/aoms/136074

Vukašinović A, Ostanek B, Klisić A, Kafedžić S, Zdravković M, Ilić I, Sopić M, Hinić S, Stefanović M, Memon L, Gaković B, Bogavac-Stanojević N, Spasojević-Kalimanovska V, Marc J, Nešković A, Kotur-Stevuljević J. Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress. in Archives of Medical Science. 2023;19(2):313-323.
doi:10.5114/aoms/136074 .

Vukašinović, Aleksandra, Ostanek, Barbara, Klisić, Aleksandra, Kafedžić, Srđan, Zdravković, Marija, Ilić, Ivan, Sopić, Miron, Hinić, Saša, Stefanović, Milica, Memon, Lidija, Gaković, Branka, Bogavac-Stanojević, Nataša, Spasojević-Kalimanovska, Vesna, Marc, Janja, Nešković, Aleksandar, Kotur-Stevuljević, Jelena, "Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress" in Archives of Medical Science, 19, no. 2 (2023):313-323,
https://doi.org/10.5114/aoms/136074 . .

TY  - JOUR
AU  - Rajkov, Branislava
AU  - Zdravković, Marija
AU  - Ninić, Ana
AU  - Brajković, Milica
AU  - Klašnja, Slobodan
AU  - Gardijan, Vera
AU  - Memon, Lidija
AU  - Munjas, Jelena
AU  - Mihajlović, Marija
AU  - Spasojević-Kalimanovska, Vesna
AU  - Radosavljević, Vojislav
AU  - Sopić, Miron
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4551
AB  - Purpose: Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators of the inflammatory changes in PBMCs in relation to the severity of OSA, and the presence of type 2 diabetes mellitus (T2DM) in OSA. Methods: Severity of OSA was defined by the apnea/hypopnea index (AHI): AHI < 30: mild to moderate OSA (MM-OSA), AHI ≥ 30: severe OSA (S-OSA). Presence of T2DM was captured: OSA with T2DM (OSA + T2DM), OSA without T2DM (OSA-T2DM). PBMC resistin, CAP1, and CD36 mRNA were determined by real-time PCR. Results: Resistin mRNA was significantly upregulated in S-OSA (N = 54) compared to the MM-OSA (N = 52, P = 0.043); CAP1 and CD36 mRNA levels did not differ between the groups (P = 0.302; P = 0.166, respectively). Resistin mRNA was significantly upregulated in OSA + T2DM (N = 29) compared to the OSA-T2DM (N = 77, P = 0.029); CAP1 and CD36 mRNA levels did not differ between the groups (P = 0.662; P = 0.108, respectively). AHI and T2DM were independent predictors of resistin mRNA above the 75th percentile (OR = 3.717 [1.152–11.991]; OR = 3.261 [1.000–10.630], P = 0.042 respectively). Conclusion: Resistin gene upregulation in S-OSA indicates its possible contribution to increased inflammation in S-OSA and makes it a possible marker of the disease severity. Resistin gene upregulation in OSA + T2DM suggests that a joint effect of these two comorbidities may have a major contribution to increased inflammation and complications that arise from this state.
PB  - Springer Nature
T2  - Sleep and Breathing
T1  - Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus
DO  - 10.1007/s11325-023-02809-0
ER  - 

@article{
author = "Rajkov, Branislava and Zdravković, Marija and Ninić, Ana and Brajković, Milica and Klašnja, Slobodan and Gardijan, Vera and Memon, Lidija and Munjas, Jelena and Mihajlović, Marija and Spasojević-Kalimanovska, Vesna and Radosavljević, Vojislav and Sopić, Miron",
year = "2023",
abstract = "Purpose: Obstructive sleep apnea (OSA) is characterised by increased systemic inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and cardiovascular disease. The aim of this investigation was to evaluate gene expression of resistin, its receptor CAP1 and CD36 as the indicators of the inflammatory changes in PBMCs in relation to the severity of OSA, and the presence of type 2 diabetes mellitus (T2DM) in OSA. Methods: Severity of OSA was defined by the apnea/hypopnea index (AHI): AHI < 30: mild to moderate OSA (MM-OSA), AHI ≥ 30: severe OSA (S-OSA). Presence of T2DM was captured: OSA with T2DM (OSA + T2DM), OSA without T2DM (OSA-T2DM). PBMC resistin, CAP1, and CD36 mRNA were determined by real-time PCR. Results: Resistin mRNA was significantly upregulated in S-OSA (N = 54) compared to the MM-OSA (N = 52, P = 0.043); CAP1 and CD36 mRNA levels did not differ between the groups (P = 0.302; P = 0.166, respectively). Resistin mRNA was significantly upregulated in OSA + T2DM (N = 29) compared to the OSA-T2DM (N = 77, P = 0.029); CAP1 and CD36 mRNA levels did not differ between the groups (P = 0.662; P = 0.108, respectively). AHI and T2DM were independent predictors of resistin mRNA above the 75th percentile (OR = 3.717 [1.152–11.991]; OR = 3.261 [1.000–10.630], P = 0.042 respectively). Conclusion: Resistin gene upregulation in S-OSA indicates its possible contribution to increased inflammation in S-OSA and makes it a possible marker of the disease severity. Resistin gene upregulation in OSA + T2DM suggests that a joint effect of these two comorbidities may have a major contribution to increased inflammation and complications that arise from this state.",
publisher = "Springer Nature",
journal = "Sleep and Breathing",
title = "Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus",
doi = "10.1007/s11325-023-02809-0"
}

Rajkov, B., Zdravković, M., Ninić, A., Brajković, M., Klašnja, S., Gardijan, V., Memon, L., Munjas, J., Mihajlović, M., Spasojević-Kalimanovska, V., Radosavljević, V.,& Sopić, M.. (2023). Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus. in Sleep and Breathing
Springer Nature..
https://doi.org/10.1007/s11325-023-02809-0

Rajkov B, Zdravković M, Ninić A, Brajković M, Klašnja S, Gardijan V, Memon L, Munjas J, Mihajlović M, Spasojević-Kalimanovska V, Radosavljević V, Sopić M. Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus. in Sleep and Breathing. 2023;.
doi:10.1007/s11325-023-02809-0 .

Rajkov, Branislava, Zdravković, Marija, Ninić, Ana, Brajković, Milica, Klašnja, Slobodan, Gardijan, Vera, Memon, Lidija, Munjas, Jelena, Mihajlović, Marija, Spasojević-Kalimanovska, Vesna, Radosavljević, Vojislav, Sopić, Miron, "Upregulation of peripheral blood mononuclear cells resistin gene expression in severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 diabetes mellitus" in Sleep and Breathing (2023),
https://doi.org/10.1007/s11325-023-02809-0 . .

TY  - JOUR
AU  - Milojević, Ana
AU  - Zdravković, Marija
AU  - Brajković, Milica
AU  - Memon, Lidija
AU  - Gardijan, Vera
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Mihajlović, Marija
AU  - Ivanišević, Jasmina
AU  - Bogavac-Stanojević, Nataša
AU  - Radosavljević, Vojislav
AU  - Spasojević-Kalimanovska, Vesna
AU  - Ninić, Ana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4199
AB  - Objectives: Obstructive sleep apnea (OSA) is a common condition closely related to obesity, insulin resistance, dyslipidemia, and cardiovascular disease. The aim of this study was to explore the possible relationship between OSA and proprotein convertase subtilisin/kexin type 9 (PCSK9). Methods: Full-night polysomnography was performed on 150 participants who were divided into three groups: controls, OSA patients on statin therapy, and OSA patients not on statin therapy. Biochemical markers, plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, and PCSK9 were determined. Results: PCSK9 was highest in OSA patients on statins compared to the control group and to OSA patients not on statins (p = 0.036 and p = 0.039, respectively), after adjustment for body mass index (BMI). LDL diameter was greater in OSA patients not on statins compared to OSA patients on statins (p = 0.032). PCSK9 was highest in the group of patients with all three risk factors (diagnosed OSA, statins, BMI ≥25 kg/m2) compared to groups with no, one, and two risk factors (p = 0.031, p = 0.001, and p = 0.029, respectively). Presence of OSA, statin therapy, and BMI ≥25 kg/m2 when combined were independently associated with higher levels of PCSK9 when adjusted for antihypertensive therapy, small dense LDL, and HDL 3c subclass (odds ratio = 2.849; interquartile range [1.026–7.912], p = 0.044). Conclusion: Statin therapy was closely related to PCSK9. OSA along with obesity and statin use induces elevation of PCSK9.
PB  - S. Karger AG Basel
T2  - Medical Principles and Practice
T1  - Effects of Apnea, Obesity, and Statin Therapy on
Proprotein Convertase Subtilisin/Kexin 9 Levels
in Patients with Obstructive Sleep Apnea
VL  - 31
IS  - 3
SP  - 293
EP  - 300
DO  - 10.1159/000524087
ER  - 

@article{
author = "Milojević, Ana and Zdravković, Marija and Brajković, Milica and Memon, Lidija and Gardijan, Vera and Vekić, Jelena and Zeljković, Aleksandra and Stefanović, Aleksandra and Mihajlović, Marija and Ivanišević, Jasmina and Bogavac-Stanojević, Nataša and Radosavljević, Vojislav and Spasojević-Kalimanovska, Vesna and Ninić, Ana",
year = "2022",
abstract = "Objectives: Obstructive sleep apnea (OSA) is a common condition closely related to obesity, insulin resistance, dyslipidemia, and cardiovascular disease. The aim of this study was to explore the possible relationship between OSA and proprotein convertase subtilisin/kexin type 9 (PCSK9). Methods: Full-night polysomnography was performed on 150 participants who were divided into three groups: controls, OSA patients on statin therapy, and OSA patients not on statin therapy. Biochemical markers, plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses, and PCSK9 were determined. Results: PCSK9 was highest in OSA patients on statins compared to the control group and to OSA patients not on statins (p = 0.036 and p = 0.039, respectively), after adjustment for body mass index (BMI). LDL diameter was greater in OSA patients not on statins compared to OSA patients on statins (p = 0.032). PCSK9 was highest in the group of patients with all three risk factors (diagnosed OSA, statins, BMI ≥25 kg/m2) compared to groups with no, one, and two risk factors (p = 0.031, p = 0.001, and p = 0.029, respectively). Presence of OSA, statin therapy, and BMI ≥25 kg/m2 when combined were independently associated with higher levels of PCSK9 when adjusted for antihypertensive therapy, small dense LDL, and HDL 3c subclass (odds ratio = 2.849; interquartile range [1.026–7.912], p = 0.044). Conclusion: Statin therapy was closely related to PCSK9. OSA along with obesity and statin use induces elevation of PCSK9.",
publisher = "S. Karger AG Basel",
journal = "Medical Principles and Practice",
title = "Effects of Apnea, Obesity, and Statin Therapy on
Proprotein Convertase Subtilisin/Kexin 9 Levels
in Patients with Obstructive Sleep Apnea",
volume = "31",
number = "3",
pages = "293-300",
doi = "10.1159/000524087"
}

Milojević, A., Zdravković, M., Brajković, M., Memon, L., Gardijan, V., Vekić, J., Zeljković, A., Stefanović, A., Mihajlović, M., Ivanišević, J., Bogavac-Stanojević, N., Radosavljević, V., Spasojević-Kalimanovska, V.,& Ninić, A.. (2022). Effects of Apnea, Obesity, and Statin Therapy on
Proprotein Convertase Subtilisin/Kexin 9 Levels
in Patients with Obstructive Sleep Apnea. in Medical Principles and Practice
S. Karger AG Basel., 31(3), 293-300.
https://doi.org/10.1159/000524087

Milojević A, Zdravković M, Brajković M, Memon L, Gardijan V, Vekić J, Zeljković A, Stefanović A, Mihajlović M, Ivanišević J, Bogavac-Stanojević N, Radosavljević V, Spasojević-Kalimanovska V, Ninić A. Effects of Apnea, Obesity, and Statin Therapy on
Proprotein Convertase Subtilisin/Kexin 9 Levels
in Patients with Obstructive Sleep Apnea. in Medical Principles and Practice. 2022;31(3):293-300.
doi:10.1159/000524087 .

Milojević, Ana, Zdravković, Marija, Brajković, Milica, Memon, Lidija, Gardijan, Vera, Vekić, Jelena, Zeljković, Aleksandra, Stefanović, Aleksandra, Mihajlović, Marija, Ivanišević, Jasmina, Bogavac-Stanojević, Nataša, Radosavljević, Vojislav, Spasojević-Kalimanovska, Vesna, Ninić, Ana, "Effects of Apnea, Obesity, and Statin Therapy on
Proprotein Convertase Subtilisin/Kexin 9 Levels
in Patients with Obstructive Sleep Apnea" in Medical Principles and Practice, 31, no. 3 (2022):293-300,
https://doi.org/10.1159/000524087 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Milojević, Ana
AU  - Vladimirov, Sandra
AU  - Zdravković, Marija
AU  - Memon, Lidija
AU  - Brajković, Milica
AU  - Gardijan, Vera
AU  - Gojković, Tamara
AU  - Stefanović, Aleksandra
AU  - Miljković-Trailović, Milica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Ninić, Ana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4322
AB  - Background and aims: Obstructive sleep apnea (OSA) is closely linked to obesity and related adverse metabolic changes, including dyslipidemia. However, it is not clear whether OSA is an independent contributing factor to dyslipidemia, or the observed association is a reflection of a concomitant presence of obesity. Additionally, dyslipidemia is usually evaluated through measurement of parameters of routine lipid status, while more precise evaluation of lipid homeostasis is rarely performed in OSA. In this study, we analyzed markers of cholesterol synthesis and absorption in patients with OSA with respect to the presence of obesity and the disease severity. Methods and results: This study enrolled 116 OSA patients. Concentrations of non-cholesterol sterols (NCS), measured by LC-MS/MS, were used as markers of cholesterol synthesis and absorption. Apnea-hypopnea index (AHI) and oxygen saturation (SaO2) were utilized as markers of OSA severity. Serum lipid status parameters were determined by routine enzymatic methods. Markers of cholesterol synthesis were increased (P = 0.005), whilst markers of cholesterol absorption decreased (P = 0.001) in obese OSA patients. Cholesterol synthesis/absorption ratio was elevated in obese subjects (P < 0.001). Concentration of cholesterol synthesis marker lathosterol was significantly higher in subjects with severe OSA (P = 0.014) and we observed a trend of decreased cholesterol absorption in these patients. AHI was revealed as an independent determinant of lathosterol concentration (P = 0.022). Conclusions: Our results suggest that the presence of obesity and severe forms of OSA is characterized by elevated endogenous cholesterol synthesis. AHI was singled out as an independent determinant of the serum level of cholesterol synthesis marker lathosterol.
PB  - Elsevier B.V.
T2  - Nutrition, Metabolism and Cardiovascular Diseases
T1  - Alterations of cholesterol synthesis and absorption in obstructive sleep apnea: Influence of obesity and disease severity
VL  - 32
IS  - 12
SP  - 2848
EP  - 2857
DO  - 10.1016/j.numecd.2022.09.006
ER  - 

@article{
author = "Zeljković, Aleksandra and Milojević, Ana and Vladimirov, Sandra and Zdravković, Marija and Memon, Lidija and Brajković, Milica and Gardijan, Vera and Gojković, Tamara and Stefanović, Aleksandra and Miljković-Trailović, Milica and Spasojević-Kalimanovska, Vesna and Ninić, Ana",
year = "2022",
abstract = "Background and aims: Obstructive sleep apnea (OSA) is closely linked to obesity and related adverse metabolic changes, including dyslipidemia. However, it is not clear whether OSA is an independent contributing factor to dyslipidemia, or the observed association is a reflection of a concomitant presence of obesity. Additionally, dyslipidemia is usually evaluated through measurement of parameters of routine lipid status, while more precise evaluation of lipid homeostasis is rarely performed in OSA. In this study, we analyzed markers of cholesterol synthesis and absorption in patients with OSA with respect to the presence of obesity and the disease severity. Methods and results: This study enrolled 116 OSA patients. Concentrations of non-cholesterol sterols (NCS), measured by LC-MS/MS, were used as markers of cholesterol synthesis and absorption. Apnea-hypopnea index (AHI) and oxygen saturation (SaO2) were utilized as markers of OSA severity. Serum lipid status parameters were determined by routine enzymatic methods. Markers of cholesterol synthesis were increased (P = 0.005), whilst markers of cholesterol absorption decreased (P = 0.001) in obese OSA patients. Cholesterol synthesis/absorption ratio was elevated in obese subjects (P < 0.001). Concentration of cholesterol synthesis marker lathosterol was significantly higher in subjects with severe OSA (P = 0.014) and we observed a trend of decreased cholesterol absorption in these patients. AHI was revealed as an independent determinant of lathosterol concentration (P = 0.022). Conclusions: Our results suggest that the presence of obesity and severe forms of OSA is characterized by elevated endogenous cholesterol synthesis. AHI was singled out as an independent determinant of the serum level of cholesterol synthesis marker lathosterol.",
publisher = "Elsevier B.V.",
journal = "Nutrition, Metabolism and Cardiovascular Diseases",
title = "Alterations of cholesterol synthesis and absorption in obstructive sleep apnea: Influence of obesity and disease severity",
volume = "32",
number = "12",
pages = "2848-2857",
doi = "10.1016/j.numecd.2022.09.006"
}

Zeljković, A., Milojević, A., Vladimirov, S., Zdravković, M., Memon, L., Brajković, M., Gardijan, V., Gojković, T., Stefanović, A., Miljković-Trailović, M., Spasojević-Kalimanovska, V.,& Ninić, A.. (2022). Alterations of cholesterol synthesis and absorption in obstructive sleep apnea: Influence of obesity and disease severity. in Nutrition, Metabolism and Cardiovascular Diseases
Elsevier B.V.., 32(12), 2848-2857.
https://doi.org/10.1016/j.numecd.2022.09.006

Zeljković A, Milojević A, Vladimirov S, Zdravković M, Memon L, Brajković M, Gardijan V, Gojković T, Stefanović A, Miljković-Trailović M, Spasojević-Kalimanovska V, Ninić A. Alterations of cholesterol synthesis and absorption in obstructive sleep apnea: Influence of obesity and disease severity. in Nutrition, Metabolism and Cardiovascular Diseases. 2022;32(12):2848-2857.
doi:10.1016/j.numecd.2022.09.006 .

Zeljković, Aleksandra, Milojević, Ana, Vladimirov, Sandra, Zdravković, Marija, Memon, Lidija, Brajković, Milica, Gardijan, Vera, Gojković, Tamara, Stefanović, Aleksandra, Miljković-Trailović, Milica, Spasojević-Kalimanovska, Vesna, Ninić, Ana, "Alterations of cholesterol synthesis and absorption in obstructive sleep apnea: Influence of obesity and disease severity" in Nutrition, Metabolism and Cardiovascular Diseases, 32, no. 12 (2022):2848-2857,
https://doi.org/10.1016/j.numecd.2022.09.006 . .

TY  - JOUR
AU  - Vuković Dejanović, Vesna
AU  - Kotur-Stevuljević, Jelena
AU  - Vukašinović, Aleksandra
AU  - Miljković, Milica
AU  - Kafedžić, Srđan
AU  - Zdravković, Marija
AU  - Ilić, Ivan
AU  - Hinić, Saša
AU  - Cerović, Milivoje
AU  - Stefanović, Milica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Memon, Lidija
AU  - Nešković, Aleksandar
AU  - Bogavac-Stanojević, Nataša
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3612
AB  - We investigated circulating levels of inflammatory biomarkers pentraxin-3 (PTX3), cyclophilin A (CypA), and heparin-binding epidermal growth factor-like growth factor (HB-EGF); oxidative stress; and antioxidant status markers in the patients with ST-segment elevation acute myocardial infarction (STEMI) to better understand a relationship between inflammation and oxidative stress. We examined the impact of oxidative stress on high values of inflammatory parameters. The study included 87 patients with STEMI and 193 controls. We observed a positive correlation between PTX3 and HB-EGF (ρ = 0.24, P = .027), CyPA, and sulfhydryl (SH) groups (ρ = 0.25, P = .026), and a negative correlation between PTX3 and SH groups (ρ = −0.35, P = .001) in patients with STEMI. To better understand the effect of the examined parameters on the occurrence of high concentrations of inflammatory parameters, we grouped them using principal component analysis. This analysis identified the 4 most contributing factors. Optimal cutoff values for discrimination of patients with STEMI from controls were calculated for PTX3 and HB-EGF. An independent predictor for PTX3 above the cutoff value was a “metabolic-oxidative stress factor” comprised of glucose and oxidative stress marker prooxidant-antioxidant balance (odds ratio = 4.449, P = .030). The results show that higher PTX3 values will occur in patients having STEMI with greater metabolic and oxidative stress status values.
PB  - SAGE journals
T2  - Angiology
T1  - Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?
VL  - 71
IS  - 8
SP  - 713
EP  - 720
DO  - 10.1177/0003319720921724
ER  - 

@article{
author = "Vuković Dejanović, Vesna and Kotur-Stevuljević, Jelena and Vukašinović, Aleksandra and Miljković, Milica and Kafedžić, Srđan and Zdravković, Marija and Ilić, Ivan and Hinić, Saša and Cerović, Milivoje and Stefanović, Milica and Spasojević-Kalimanovska, Vesna and Memon, Lidija and Nešković, Aleksandar and Bogavac-Stanojević, Nataša",
year = "2020",
abstract = "We investigated circulating levels of inflammatory biomarkers pentraxin-3 (PTX3), cyclophilin A (CypA), and heparin-binding epidermal growth factor-like growth factor (HB-EGF); oxidative stress; and antioxidant status markers in the patients with ST-segment elevation acute myocardial infarction (STEMI) to better understand a relationship between inflammation and oxidative stress. We examined the impact of oxidative stress on high values of inflammatory parameters. The study included 87 patients with STEMI and 193 controls. We observed a positive correlation between PTX3 and HB-EGF (ρ = 0.24, P = .027), CyPA, and sulfhydryl (SH) groups (ρ = 0.25, P = .026), and a negative correlation between PTX3 and SH groups (ρ = −0.35, P = .001) in patients with STEMI. To better understand the effect of the examined parameters on the occurrence of high concentrations of inflammatory parameters, we grouped them using principal component analysis. This analysis identified the 4 most contributing factors. Optimal cutoff values for discrimination of patients with STEMI from controls were calculated for PTX3 and HB-EGF. An independent predictor for PTX3 above the cutoff value was a “metabolic-oxidative stress factor” comprised of glucose and oxidative stress marker prooxidant-antioxidant balance (odds ratio = 4.449, P = .030). The results show that higher PTX3 values will occur in patients having STEMI with greater metabolic and oxidative stress status values.",
publisher = "SAGE journals",
journal = "Angiology",
title = "Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?",
volume = "71",
number = "8",
pages = "713-720",
doi = "10.1177/0003319720921724"
}

Vuković Dejanović, V., Kotur-Stevuljević, J., Vukašinović, A., Miljković, M., Kafedžić, S., Zdravković, M., Ilić, I., Hinić, S., Cerović, M., Stefanović, M., Spasojević-Kalimanovska, V., Memon, L., Nešković, A.,& Bogavac-Stanojević, N.. (2020). Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?. in Angiology
SAGE journals., 71(8), 713-720.
https://doi.org/10.1177/0003319720921724

Vuković Dejanović V, Kotur-Stevuljević J, Vukašinović A, Miljković M, Kafedžić S, Zdravković M, Ilić I, Hinić S, Cerović M, Stefanović M, Spasojević-Kalimanovska V, Memon L, Nešković A, Bogavac-Stanojević N. Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?. in Angiology. 2020;71(8):713-720.
doi:10.1177/0003319720921724 .

Vuković Dejanović, Vesna, Kotur-Stevuljević, Jelena, Vukašinović, Aleksandra, Miljković, Milica, Kafedžić, Srđan, Zdravković, Marija, Ilić, Ivan, Hinić, Saša, Cerović, Milivoje, Stefanović, Milica, Spasojević-Kalimanovska, Vesna, Memon, Lidija, Nešković, Aleksandar, Bogavac-Stanojević, Nataša, "Oxidative Stress and Inflammatory Markers PTX3, CypA, and HB-EGF: How Are They Linked in Patients With STEMI?" in Angiology, 71, no. 8 (2020):713-720,
https://doi.org/10.1177/0003319720921724 . .

TY  - JOUR
AU  - Ninić, Ana
AU  - Zdravković, Marija
AU  - Radosavljević, Vojislav
AU  - Gardijan, Vera
AU  - Memon, Lidija
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3769
AB  - Obstructive  sleep  apnea  (OSA)  as  a  worldwide  prevalent  condition  carries  risk  for cardiovascular  and  metabolic  diseases,  ultimately  increasingoverall  mortality  rates.  Non-alcoholic fatty liver disease  (NAFLD) can be considered as the primary metabolic  disease,  but also as a coexisting OSA comorbidity. Although prevalence of NAFLD covers quarter of world population, it increases with OSA presence. It can be speculated that chronic intermittent hypoxia (CIH)  and  sympathetic  nervous  system  overactivity  are  involved  in  NAFLD  pathogenesis  and progression   from   simple   steatosis throughsteatohepatitis   to   fibrosis.   CIH   provides   the environment  for  liveroxidative  stress,  inflammation  and  increases  the  expression  of  genes involved in cholesterol and fatty acids synthesis. Catecholamines increase β-oxidation in liver and release free fatty acids from adipose tissue in plasma which inhibit insulin effects. Obesity and insulin resistance as key playersin NAFLD development and advancement, deepen vicious circle of oxidative stress, inflammation and dyslipidemia. If not treated, OSA in NAFLD patients has been  associated  with inflammation, hepatocytes’ necrosis,  and  fibrosis.  Continuous  positive airway pressure (CPAP) represents gold standard for OSA therapy, allowing the unimpeded air passage through upper parts of respiratory system. However, it has been demonstrated that CPAP therapyhave beneficial effects on cardiometabolic outcomes and slowliver degeneration
AB  - Opstruktivna apneja u snu (OSA) kao oboljenje prevalentno u svetu nosi rizik za nastanak kardiovaskularnih i metaboličkih bolesti, povećavajući ukupnu smrtnost. Bolest nealkoholne masne jetre (eng. non-alcoholic fatty liver disease -NAFLD) se može smatrati primarnom metaboličkom bolešću, ali kao i komorbiditet OSA. Iako prevalenca NAFLD obuhvata četvrtinu svetske populacije, ona se povećava sa prisustvom OSA. Pretpostavlja se da su hronična intermitentna hipoksija (eng. chronic intermittent hypoxia -CIH) i prekomerna aktivnost simpatičkog nervnog sistema uključeni u patogenezu NAFLD i progresiju od steatoze preko steatohepatitisa do fibroze. U jetri CIH stvara uslove za oksidativni stres, inflamaciju i povećava ekspresiju gena koji učestvuju u sintezi holesterola i masnih kiselina. Kateholamini stimulišu b-oksidaciju masnih kiselina u jetri i oslobađaju slobodne masne kiseline iz masnog tkiva u plazmu, koje inhibiraju dejstva insulina. Gojaznost i insulinska rezistencija kao ključni faktori u razvoju i napredovanju NAFLD produbljuju začarani krug oksidativnog stresa, inflamacije i dislipidemije. Ako se ne leči, OSA kod pacijenata sa NAFLD je povezana sa inflamacijom, nekrozom hepatocita i fibrozom. Kontinuirani pozitivni pritisak vazduha (eng. continuous positive airway pressure -CPAP) predstavlja zlatni standard u terapiji OSA, koji omogućava neometani prolaz vazduha kroz gornje delove respiratornog sistema. Međutim, CPAP terapija je pokazala da ima povoljne efekte na kardiometaboličke ishode i da usporava degeneraciju jetre.
PB  - Pharmaceutical Association of Serbia
T2  - Arhiv za farmaciju
T1  - Non-alcoholic fatty liver disease as metabolic consequence of obstructive sleep apnea
T1  - Bolest nealkoholne masne jetre kao metabolička posledica opstruktivne apneje u snu
VL  - 70
IS  - 6
SP  - 319
EP  - 331
DO  - 10.5937/arhfarm70-27586
ER  - 

@article{
author = "Ninić, Ana and Zdravković, Marija and Radosavljević, Vojislav and Gardijan, Vera and Memon, Lidija and Vekić, Jelena and Spasojević-Kalimanovska, Vesna",
year = "2020",
abstract = "Obstructive  sleep  apnea  (OSA)  as  a  worldwide  prevalent  condition  carries  risk  for cardiovascular  and  metabolic  diseases,  ultimately  increasingoverall  mortality  rates.  Non-alcoholic fatty liver disease  (NAFLD) can be considered as the primary metabolic  disease,  but also as a coexisting OSA comorbidity. Although prevalence of NAFLD covers quarter of world population, it increases with OSA presence. It can be speculated that chronic intermittent hypoxia (CIH)  and  sympathetic  nervous  system  overactivity  are  involved  in  NAFLD  pathogenesis  and progression   from   simple   steatosis throughsteatohepatitis   to   fibrosis.   CIH   provides   the environment  for  liveroxidative  stress,  inflammation  and  increases  the  expression  of  genes involved in cholesterol and fatty acids synthesis. Catecholamines increase β-oxidation in liver and release free fatty acids from adipose tissue in plasma which inhibit insulin effects. Obesity and insulin resistance as key playersin NAFLD development and advancement, deepen vicious circle of oxidative stress, inflammation and dyslipidemia. If not treated, OSA in NAFLD patients has been  associated  with inflammation, hepatocytes’ necrosis,  and  fibrosis.  Continuous  positive airway pressure (CPAP) represents gold standard for OSA therapy, allowing the unimpeded air passage through upper parts of respiratory system. However, it has been demonstrated that CPAP therapyhave beneficial effects on cardiometabolic outcomes and slowliver degeneration, Opstruktivna apneja u snu (OSA) kao oboljenje prevalentno u svetu nosi rizik za nastanak kardiovaskularnih i metaboličkih bolesti, povećavajući ukupnu smrtnost. Bolest nealkoholne masne jetre (eng. non-alcoholic fatty liver disease -NAFLD) se može smatrati primarnom metaboličkom bolešću, ali kao i komorbiditet OSA. Iako prevalenca NAFLD obuhvata četvrtinu svetske populacije, ona se povećava sa prisustvom OSA. Pretpostavlja se da su hronična intermitentna hipoksija (eng. chronic intermittent hypoxia -CIH) i prekomerna aktivnost simpatičkog nervnog sistema uključeni u patogenezu NAFLD i progresiju od steatoze preko steatohepatitisa do fibroze. U jetri CIH stvara uslove za oksidativni stres, inflamaciju i povećava ekspresiju gena koji učestvuju u sintezi holesterola i masnih kiselina. Kateholamini stimulišu b-oksidaciju masnih kiselina u jetri i oslobađaju slobodne masne kiseline iz masnog tkiva u plazmu, koje inhibiraju dejstva insulina. Gojaznost i insulinska rezistencija kao ključni faktori u razvoju i napredovanju NAFLD produbljuju začarani krug oksidativnog stresa, inflamacije i dislipidemije. Ako se ne leči, OSA kod pacijenata sa NAFLD je povezana sa inflamacijom, nekrozom hepatocita i fibrozom. Kontinuirani pozitivni pritisak vazduha (eng. continuous positive airway pressure -CPAP) predstavlja zlatni standard u terapiji OSA, koji omogućava neometani prolaz vazduha kroz gornje delove respiratornog sistema. Međutim, CPAP terapija je pokazala da ima povoljne efekte na kardiometaboličke ishode i da usporava degeneraciju jetre.",
publisher = "Pharmaceutical Association of Serbia",
journal = "Arhiv za farmaciju",
title = "Non-alcoholic fatty liver disease as metabolic consequence of obstructive sleep apnea, Bolest nealkoholne masne jetre kao metabolička posledica opstruktivne apneje u snu",
volume = "70",
number = "6",
pages = "319-331",
doi = "10.5937/arhfarm70-27586"
}

Ninić, A., Zdravković, M., Radosavljević, V., Gardijan, V., Memon, L., Vekić, J.,& Spasojević-Kalimanovska, V.. (2020). Non-alcoholic fatty liver disease as metabolic consequence of obstructive sleep apnea. in Arhiv za farmaciju
Pharmaceutical Association of Serbia., 70(6), 319-331.
https://doi.org/10.5937/arhfarm70-27586

Ninić A, Zdravković M, Radosavljević V, Gardijan V, Memon L, Vekić J, Spasojević-Kalimanovska V. Non-alcoholic fatty liver disease as metabolic consequence of obstructive sleep apnea. in Arhiv za farmaciju. 2020;70(6):319-331.
doi:10.5937/arhfarm70-27586 .

Ninić, Ana, Zdravković, Marija, Radosavljević, Vojislav, Gardijan, Vera, Memon, Lidija, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, "Non-alcoholic fatty liver disease as metabolic consequence of obstructive sleep apnea" in Arhiv za farmaciju, 70, no. 6 (2020):319-331,
https://doi.org/10.5937/arhfarm70-27586 . .

TY  - JOUR
AU  - Đurašević, Siniša
AU  - Nikolić, Gorana
AU  - Zaletel,  Ivan
AU  - Grigorov,  Ilijana
AU  - Memon, Lidija
AU  - Mitić-Ćulafić, Dragana
AU  - Vujović, Predrag
AU  - Đorđević, Jelena
AU  - Todorović, Zoran
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3519
AB  - Non-diabetic and alloxan-induced diabetic rats were fed with standard laboratory food enriched with 20% virgincoconut oil for 16 weeks. In non-diabetic animals coconut oil improved insulin sensitivity and ability to controlglycaemia and decreased the serum triglycerides for almost 50% in comparison with controls. Supplementationwith coconut oil caused liver steatosis in both non-diabetic and diabetic animals. However, the severity ofsteatosis was lower in diabetic animals compared to non-diabetic animals. Coconut oil had no effects on hearthistology, ascending and abdominal aorta wall thickening and atherosclerotic plaques development neither innon-diabetic nor in diabetic animals. While alloxan treatment caused Type I diabetes in rats, supplementationwith coconut oil in combination with the alloxan unexpectedly resulted in Type II diabetes. The development ofsevere insulin resistance and deterioration in serum lipid profile implied that the use of coconut oil is contra-indicated in diabetic condition.
PB  - Elsevier
T2  - Journal of Functional Foods
T1  - Distinct effects of virgin coconut oil supplementation on the glucose and lipid homeostasis in non-diabetic and alloxan-induced diabetic rats
VL  - 64
DO  - 10.1016/j.jff.2019.103601
ER  - 

@article{
author = "Đurašević, Siniša and Nikolić, Gorana and Zaletel,  Ivan and Grigorov,  Ilijana and Memon, Lidija and Mitić-Ćulafić, Dragana and Vujović, Predrag and Đorđević, Jelena and Todorović, Zoran",
year = "2020",
abstract = "Non-diabetic and alloxan-induced diabetic rats were fed with standard laboratory food enriched with 20% virgincoconut oil for 16 weeks. In non-diabetic animals coconut oil improved insulin sensitivity and ability to controlglycaemia and decreased the serum triglycerides for almost 50% in comparison with controls. Supplementationwith coconut oil caused liver steatosis in both non-diabetic and diabetic animals. However, the severity ofsteatosis was lower in diabetic animals compared to non-diabetic animals. Coconut oil had no effects on hearthistology, ascending and abdominal aorta wall thickening and atherosclerotic plaques development neither innon-diabetic nor in diabetic animals. While alloxan treatment caused Type I diabetes in rats, supplementationwith coconut oil in combination with the alloxan unexpectedly resulted in Type II diabetes. The development ofsevere insulin resistance and deterioration in serum lipid profile implied that the use of coconut oil is contra-indicated in diabetic condition.",
publisher = "Elsevier",
journal = "Journal of Functional Foods",
title = "Distinct effects of virgin coconut oil supplementation on the glucose and lipid homeostasis in non-diabetic and alloxan-induced diabetic rats",
volume = "64",
doi = "10.1016/j.jff.2019.103601"
}

Đurašević, S., Nikolić, G., Zaletel, I., Grigorov, I., Memon, L., Mitić-Ćulafić, D., Vujović, P., Đorđević, J.,& Todorović, Z.. (2020). Distinct effects of virgin coconut oil supplementation on the glucose and lipid homeostasis in non-diabetic and alloxan-induced diabetic rats. in Journal of Functional Foods
Elsevier., 64.
https://doi.org/10.1016/j.jff.2019.103601

Đurašević S, Nikolić G, Zaletel I, Grigorov I, Memon L, Mitić-Ćulafić D, Vujović P, Đorđević J, Todorović Z. Distinct effects of virgin coconut oil supplementation on the glucose and lipid homeostasis in non-diabetic and alloxan-induced diabetic rats. in Journal of Functional Foods. 2020;64.
doi:10.1016/j.jff.2019.103601 .

Đurašević, Siniša, Nikolić, Gorana, Zaletel,  Ivan, Grigorov,  Ilijana, Memon, Lidija, Mitić-Ćulafić, Dragana, Vujović, Predrag, Đorđević, Jelena, Todorović, Zoran, "Distinct effects of virgin coconut oil supplementation on the glucose and lipid homeostasis in non-diabetic and alloxan-induced diabetic rats" in Journal of Functional Foods, 64 (2020),
https://doi.org/10.1016/j.jff.2019.103601 . .

TY  - JOUR
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Aleksić, Aleksandra
AU  - Gacić, Jasna
AU  - Memon, Lidija
AU  - Simić-Ogrizović, Sanja
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3166
AB  - Background. The role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in sepsis after major abdominal surgery and sepsis-associated organ dysfunction is unexplored. Materials and Methods. Fifty-three patients with sepsis after major abdominal surgery were compared to 50 operated and 50 nonoperated controls. MMP-9, TIMP-1, biomarkers of inflammation, kidney and liver injury, coagulation, and metabolic disorders were measured daily during 96 h following diagnosis of sepsis and once in controls. MMP-9/TIMP-1 ratios and disease severity scores were calculated. Use of vasopressors/inotropes, mechanical ventilation, and survival were recorded. Results. Septic patients had lower MMP-9 and MMP-9/TIMP-1 ratios but higher TIMP-1 levels compared to controls. AUC-ROC for diagnosis of sepsis was 0.940 and 0.854 for TIMP-1 and 0.924 and 0.788 for MMP-9/TIMP-1 ratio (sepsis versus nonoperated and sepsis versus operated controls, resp.). Lower MMP-9 and MMP-9/TIMP-1 ratio and higher TIMP-1 levels were associated with shorter survival. MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio correlated with biomarkers of inflammation, kidney and liver injury, coagulation, metabolic disorders, and disease severity scores. Use of vasopressors/inotropes was associated with higher TIMP-1 levels. Conclusions. MMP-9, TIMP-1, and MMP-9/TIMP ratio were good diagnostic or prognostic biomarkers of sepsis after major abdominal surgery and were linked to sepsis-associated organ dysfunction.
PB  - Hindawi Ltd, London
T2  - Disease Markers
T1  - Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery
DO  - 10.1155/2018/5064684
ER  - 

@article{
author = "Bojić, Suzana and Kotur-Stevuljević, Jelena and Aleksić, Aleksandra and Gacić, Jasna and Memon, Lidija and Simić-Ogrizović, Sanja",
year = "2018",
abstract = "Background. The role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in sepsis after major abdominal surgery and sepsis-associated organ dysfunction is unexplored. Materials and Methods. Fifty-three patients with sepsis after major abdominal surgery were compared to 50 operated and 50 nonoperated controls. MMP-9, TIMP-1, biomarkers of inflammation, kidney and liver injury, coagulation, and metabolic disorders were measured daily during 96 h following diagnosis of sepsis and once in controls. MMP-9/TIMP-1 ratios and disease severity scores were calculated. Use of vasopressors/inotropes, mechanical ventilation, and survival were recorded. Results. Septic patients had lower MMP-9 and MMP-9/TIMP-1 ratios but higher TIMP-1 levels compared to controls. AUC-ROC for diagnosis of sepsis was 0.940 and 0.854 for TIMP-1 and 0.924 and 0.788 for MMP-9/TIMP-1 ratio (sepsis versus nonoperated and sepsis versus operated controls, resp.). Lower MMP-9 and MMP-9/TIMP-1 ratio and higher TIMP-1 levels were associated with shorter survival. MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio correlated with biomarkers of inflammation, kidney and liver injury, coagulation, metabolic disorders, and disease severity scores. Use of vasopressors/inotropes was associated with higher TIMP-1 levels. Conclusions. MMP-9, TIMP-1, and MMP-9/TIMP ratio were good diagnostic or prognostic biomarkers of sepsis after major abdominal surgery and were linked to sepsis-associated organ dysfunction.",
publisher = "Hindawi Ltd, London",
journal = "Disease Markers",
title = "Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery",
doi = "10.1155/2018/5064684"
}

Bojić, S., Kotur-Stevuljević, J., Aleksić, A., Gacić, J., Memon, L.,& Simić-Ogrizović, S.. (2018). Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery. in Disease Markers
Hindawi Ltd, London..
https://doi.org/10.1155/2018/5064684

Bojić S, Kotur-Stevuljević J, Aleksić A, Gacić J, Memon L, Simić-Ogrizović S. Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery. in Disease Markers. 2018;.
doi:10.1155/2018/5064684 .

Bojić, Suzana, Kotur-Stevuljević, Jelena, Aleksić, Aleksandra, Gacić, Jasna, Memon, Lidija, Simić-Ogrizović, Sanja, "Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis after Major Abdominal Surgery" in Disease Markers (2018),
https://doi.org/10.1155/2018/5064684 . .

TY  - JOUR
AU  - Stanisavljević, Nataša
AU  - Stojanović, Ljudmila
AU  - Marisavljević, D.
AU  - Đoković, A.
AU  - Dopsaj, Violeta
AU  - Kotur-Stevuljević, Jelena
AU  - Martinović, Jelena
AU  - Memon, Lidija
AU  - Radovanović, Slavica
AU  - Todić, B.
AU  - Lisulov, D.
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2710
AB  - The aim of this study was to evaluate oxidative stress markers and it relations to endothelial damage as risk factor for thrombosis in patients with primary (PAPS) and secondary (SAPS) antiphospholipid syndrome (APS) in correlation to traditional risk factors. Flow-mediated (FMD) and nitroglycerine (NMD)-induced dilation of the brachial artery were studied in 140 APS patients (90 PAPS, 50 SAPS) and 40 controls matched by age, sex, and conventional risk factors for atherosclerosis. Markers of oxidative stress, lipid hydroperoxydes (LOOH), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG), and paraoxonase 1 activity (PON1) were determined by spectrophotometric method. Oxidative stress dominates in APS patients. LOOH and AOPP correlate to lipid fractions (p  lt  0.05), unlike PON1, tSHG that correlated to antiphospholipid antibody positivity (p  lt  0.05). FMD was lower in APS patients comparing to controls (p  lt  0.001). Cholesterol is independent variable for FMD impairment in control group (p = 0.011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively). Combined predictive of aCL and LOOH is better for FMD impairment than LOOH alone in both PAPS and SAPS patients (AUC 0.727, p = 0.001, 95 % CI 0.616-0.837 and AUC 0.824, pE,0.001, 95 % CI 0.690-0.957, respectively). Lipid peroxidation is independent predictor for endothelial dysfunction in APS patients. We demonstrated synergistic effect of aCL and LOOH as risk for endothelial impairment in both PAPS and SAPS patients.
PB  - Springer London Ltd, London
T2  - Clinical Rheumatology
T1  - Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients
VL  - 35
IS  - 10
SP  - 2485
EP  - 2493
DO  - 10.1007/s10067-016-3369-8
ER  - 

@article{
author = "Stanisavljević, Nataša and Stojanović, Ljudmila and Marisavljević, D. and Đoković, A. and Dopsaj, Violeta and Kotur-Stevuljević, Jelena and Martinović, Jelena and Memon, Lidija and Radovanović, Slavica and Todić, B. and Lisulov, D.",
year = "2016",
abstract = "The aim of this study was to evaluate oxidative stress markers and it relations to endothelial damage as risk factor for thrombosis in patients with primary (PAPS) and secondary (SAPS) antiphospholipid syndrome (APS) in correlation to traditional risk factors. Flow-mediated (FMD) and nitroglycerine (NMD)-induced dilation of the brachial artery were studied in 140 APS patients (90 PAPS, 50 SAPS) and 40 controls matched by age, sex, and conventional risk factors for atherosclerosis. Markers of oxidative stress, lipid hydroperoxydes (LOOH), advanced oxidation protein products (AOPP), total sulfhydryl groups (tSHG), and paraoxonase 1 activity (PON1) were determined by spectrophotometric method. Oxidative stress dominates in APS patients. LOOH and AOPP correlate to lipid fractions (p  lt  0.05), unlike PON1, tSHG that correlated to antiphospholipid antibody positivity (p  lt  0.05). FMD was lower in APS patients comparing to controls (p  lt  0.001). Cholesterol is independent variable for FMD impairment in control group (p = 0.011); LOOH in PAPS (p = 0.004); LOOH, aCL, and triglycerides in SAPS patients (p = 0.009, p = 0.049, and p = 0.012, respectively). Combined predictive of aCL and LOOH is better for FMD impairment than LOOH alone in both PAPS and SAPS patients (AUC 0.727, p = 0.001, 95 % CI 0.616-0.837 and AUC 0.824, pE,0.001, 95 % CI 0.690-0.957, respectively). Lipid peroxidation is independent predictor for endothelial dysfunction in APS patients. We demonstrated synergistic effect of aCL and LOOH as risk for endothelial impairment in both PAPS and SAPS patients.",
publisher = "Springer London Ltd, London",
journal = "Clinical Rheumatology",
title = "Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients",
volume = "35",
number = "10",
pages = "2485-2493",
doi = "10.1007/s10067-016-3369-8"
}

Stanisavljević, N., Stojanović, L., Marisavljević, D., Đoković, A., Dopsaj, V., Kotur-Stevuljević, J., Martinović, J., Memon, L., Radovanović, S., Todić, B.,& Lisulov, D.. (2016). Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients. in Clinical Rheumatology
Springer London Ltd, London., 35(10), 2485-2493.
https://doi.org/10.1007/s10067-016-3369-8

Stanisavljević N, Stojanović L, Marisavljević D, Đoković A, Dopsaj V, Kotur-Stevuljević J, Martinović J, Memon L, Radovanović S, Todić B, Lisulov D. Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients. in Clinical Rheumatology. 2016;35(10):2485-2493.
doi:10.1007/s10067-016-3369-8 .

Stanisavljević, Nataša, Stojanović, Ljudmila, Marisavljević, D., Đoković, A., Dopsaj, Violeta, Kotur-Stevuljević, Jelena, Martinović, Jelena, Memon, Lidija, Radovanović, Slavica, Todić, B., Lisulov, D., "Lipid peroxidation as risk factor for endothelial dysfunction in antiphospholipid syndrome patients" in Clinical Rheumatology, 35, no. 10 (2016):2485-2493,
https://doi.org/10.1007/s10067-016-3369-8 . .

TY  - JOUR
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Kalezić, Nevena
AU  - Stevanović, Predrag
AU  - Jelić-Ivanović, Zorana
AU  - Bilanović, Dragoljub
AU  - Memon, Lidija
AU  - Damnjanović, Mladen
AU  - Kalaba, Zdravko
AU  - Simić-Ogrizović, Sanja
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2313
AB  - Sepsis-associated acute kidney injury (SA-AKI) severely impacts morbidity and mortality in surgical patients with sepsis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix rnetalloproteinase-1 (TIMP-1) have an important role in pathophysiology of sepsis but they have been unexplored in SA-AKI. We aimed to investigate the role of MMP-9 and TIMP-1 in septic surgical patients with SA-AKI and to evaluate them as diagnostic biomarkers of SA-AKI. This prospective observational study compared 53 major abdominal surgery patients with sepsis divided into SA-AKI (n = 37) and non-SA-AKI (n = 16) group to 50 controls without sepsis matched by age, gender, comorbidities and type of surgery. Blood and urine samples from septic patients were collected on admission to ICU and 24, 48, 72 and 96 h later and once from the controls. The levels of MMP-9, TIMP-1, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1, urea and creatinine were measured. MMP-9/TIMP-1 ratio and disease severity scores, such as Sequential Organ Failure Assessment (SOFA), were calculated. Septic patients with SA-AKI had higher serum TIMP-1 levels and lower serum MMP-9 levels and lower MMP-9/TIMP ratio, compared to septic patients without SA-AKI and controls. The levels of these biomarkers did not change significantly over time. MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio correlated with urea, creatinine, NGAL, and SOFA scores. Moreover, using the area under ROC curve, we showed that TIMP-1 and MMP-9/TIMP-1 ratio, but not MMP-9, were good diagnostic biomarkers of SA-AKI. We report for the first time the potential diagnostic value of TIMP-1 and MMP-9/TIMP-1 ratio in SA-AKI.
PB  - Tohoku Univ Medical Press, Sendai
T2  - Toxicological and Environmental Chemistry
T1  - Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury
VL  - 237
IS  - 2
SP  - 103
EP  - 109
DO  - 10.1620/tjem.237.103
ER  - 

@article{
author = "Bojić, Suzana and Kotur-Stevuljević, Jelena and Kalezić, Nevena and Stevanović, Predrag and Jelić-Ivanović, Zorana and Bilanović, Dragoljub and Memon, Lidija and Damnjanović, Mladen and Kalaba, Zdravko and Simić-Ogrizović, Sanja",
year = "2015",
abstract = "Sepsis-associated acute kidney injury (SA-AKI) severely impacts morbidity and mortality in surgical patients with sepsis. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix rnetalloproteinase-1 (TIMP-1) have an important role in pathophysiology of sepsis but they have been unexplored in SA-AKI. We aimed to investigate the role of MMP-9 and TIMP-1 in septic surgical patients with SA-AKI and to evaluate them as diagnostic biomarkers of SA-AKI. This prospective observational study compared 53 major abdominal surgery patients with sepsis divided into SA-AKI (n = 37) and non-SA-AKI (n = 16) group to 50 controls without sepsis matched by age, gender, comorbidities and type of surgery. Blood and urine samples from septic patients were collected on admission to ICU and 24, 48, 72 and 96 h later and once from the controls. The levels of MMP-9, TIMP-1, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1, urea and creatinine were measured. MMP-9/TIMP-1 ratio and disease severity scores, such as Sequential Organ Failure Assessment (SOFA), were calculated. Septic patients with SA-AKI had higher serum TIMP-1 levels and lower serum MMP-9 levels and lower MMP-9/TIMP ratio, compared to septic patients without SA-AKI and controls. The levels of these biomarkers did not change significantly over time. MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio correlated with urea, creatinine, NGAL, and SOFA scores. Moreover, using the area under ROC curve, we showed that TIMP-1 and MMP-9/TIMP-1 ratio, but not MMP-9, were good diagnostic biomarkers of SA-AKI. We report for the first time the potential diagnostic value of TIMP-1 and MMP-9/TIMP-1 ratio in SA-AKI.",
publisher = "Tohoku Univ Medical Press, Sendai",
journal = "Toxicological and Environmental Chemistry",
title = "Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury",
volume = "237",
number = "2",
pages = "103-109",
doi = "10.1620/tjem.237.103"
}

Bojić, S., Kotur-Stevuljević, J., Kalezić, N., Stevanović, P., Jelić-Ivanović, Z., Bilanović, D., Memon, L., Damnjanović, M., Kalaba, Z.,& Simić-Ogrizović, S.. (2015). Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury. in Toxicological and Environmental Chemistry
Tohoku Univ Medical Press, Sendai., 237(2), 103-109.
https://doi.org/10.1620/tjem.237.103

Bojić S, Kotur-Stevuljević J, Kalezić N, Stevanović P, Jelić-Ivanović Z, Bilanović D, Memon L, Damnjanović M, Kalaba Z, Simić-Ogrizović S. Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury. in Toxicological and Environmental Chemistry. 2015;237(2):103-109.
doi:10.1620/tjem.237.103 .

Bojić, Suzana, Kotur-Stevuljević, Jelena, Kalezić, Nevena, Stevanović, Predrag, Jelić-Ivanović, Zorana, Bilanović, Dragoljub, Memon, Lidija, Damnjanović, Mladen, Kalaba, Zdravko, Simić-Ogrizović, Sanja, "Diagnostic Value of Matrix Metalloproteinase-9 and Tissue Inhibitor of Matrix Metalloproteinase-1 in Sepsis-Associated Acute Kidney Injury" in Toxicological and Environmental Chemistry, 237, no. 2 (2015):103-109,
https://doi.org/10.1620/tjem.237.103 . .

TY  - JOUR
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
AU  - Jelić-Ivanović, Zorana
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Memon, Lidija
AU  - Bogavac-Stanojević, Nataša
AU  - Topić, Aleksandra
AU  - Spasić, Slavica
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2164
AB  - Background A research on novel cardiovascular risk factors is mainly focused on patients with clinically verified coronary artery disease (CAD), while less is known about their presence in symptomatic patients, but without angiographically proven occlusion of coronary arteries. The aim of this study was to compare plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in stable angina patients with and without significant obstructive CAD. Methods LDL and HDL subclasses were analysed in 100 stable angina patients with >= 50% of obstruction and 40 patients with less than 50% of luminal narrowing, as assessed by coronary angiography. Results Patients with  lt 50% of obstruction had reduced mean HDL size and higher proportion of small HDL particles (P  lt  0.05). HDL size and proportion of small HDL particles were significant and independent predictors of obstructive CAD (P  lt  0.05, respectively). Conclusions Stable angina patients with
PB  - Sage Publications Inc, Thousand Oaks
T2  - Annals of Clinical Biochemistry
T1  - Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients
VL  - 51
IS  - 3
SP  - 412
EP  - 415
DO  - 10.1177/0004563213499908
ER  - 

@article{
author = "Zeljković, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna and Jelić-Ivanović, Zorana and Kalimanovska-Oštrić, Dimitra and Memon, Lidija and Bogavac-Stanojević, Nataša and Topić, Aleksandra and Spasić, Slavica",
year = "2014",
abstract = "Background A research on novel cardiovascular risk factors is mainly focused on patients with clinically verified coronary artery disease (CAD), while less is known about their presence in symptomatic patients, but without angiographically proven occlusion of coronary arteries. The aim of this study was to compare plasma low-density lipoprotein (LDL) and high-density lipoprotein (HDL) size and subclasses in stable angina patients with and without significant obstructive CAD. Methods LDL and HDL subclasses were analysed in 100 stable angina patients with >= 50% of obstruction and 40 patients with less than 50% of luminal narrowing, as assessed by coronary angiography. Results Patients with  lt 50% of obstruction had reduced mean HDL size and higher proportion of small HDL particles (P  lt  0.05). HDL size and proportion of small HDL particles were significant and independent predictors of obstructive CAD (P  lt  0.05, respectively). Conclusions Stable angina patients with",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Annals of Clinical Biochemistry",
title = "Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients",
volume = "51",
number = "3",
pages = "412-415",
doi = "10.1177/0004563213499908"
}

Zeljković, A., Vekić, J., Spasojević-Kalimanovska, V., Jelić-Ivanović, Z., Kalimanovska-Oštrić, D., Memon, L., Bogavac-Stanojević, N., Topić, A.,& Spasić, S.. (2014). Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients. in Annals of Clinical Biochemistry
Sage Publications Inc, Thousand Oaks., 51(3), 412-415.
https://doi.org/10.1177/0004563213499908

Zeljković A, Vekić J, Spasojević-Kalimanovska V, Jelić-Ivanović Z, Kalimanovska-Oštrić D, Memon L, Bogavac-Stanojević N, Topić A, Spasić S. Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients. in Annals of Clinical Biochemistry. 2014;51(3):412-415.
doi:10.1177/0004563213499908 .

Zeljković, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, Jelić-Ivanović, Zorana, Kalimanovska-Oštrić, Dimitra, Memon, Lidija, Bogavac-Stanojević, Nataša, Topić, Aleksandra, Spasić, Slavica, "Smaller HDL particles are associated with absence of obstructive coronary artery disease in stable angina pectoris patients" in Annals of Clinical Biochemistry, 51, no. 3 (2014):412-415,
https://doi.org/10.1177/0004563213499908 . .

TY  - JOUR
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Memon, Lidija
AU  - Spasić, Slavica
AU  - Kotur-Stevuljević, Jelena
AU  - Jelić-Ivanović, Zorana
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2236
AB  - Objectives: Epidemiological evidence concerning the role of iron, a lipid peroxidation catalyst, in atherosclerosis and coronary artery disease (CAD) is inconsistent. Design and methods: Exploratory factor analysis was used to examine the potential clustering of variables known to be associated with CAD using data from 188 patients with angiographically-approved disease. The resulting factors were then tested for their association with serum ferritin and soluble transferrin receptor (sTfR) as indicators of body iron status. Results: Factor analysis resulted in a reduction of a variable number from the original 15 to 5 composite clusters. These factors were interpreted as (1) "proatherogenic factor" with positive loadings of TC, LDL-C, apoB and TG; (2) "inflammatory factor" with positive loadings of hsCRP, fibrinogen and MDA; (3) "antiatherogenic factor" with positive loadings of HDL-C and apoA-I; (4) "obesity factor" with positive loadings of weight and waist; and (5) "antioxidative status factor" with positive loadings of SOD and age and negative loading of superoxide anion. "Inflammatory", "obesity" and "antiatherogenic" factors predicted high ferritin values and the "proatherogenic factor" predicted high sTfR values. We compared the ability of the "proatherogenic factor" with that of a multi-variable logistic model that included the "proatherogenic factor" and sTfR values in predicting significant stenosis in patients. The area under the ROC curve was 0.692 vs. 0.821, respectively. Conclusions: "Inflammatory", "obesity", "antiatherogenic" and "proatherogenic" factors were associated with increased parameters of body iron status. The measurement of sTfR improves the prediction of CAD based on clustered cardiovascular risk factors.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Factor analysis of risk variables associated with iron status in patients with coronary artery disease
VL  - 47
IS  - 7-8
SP  - 564
EP  - 569
DO  - 10.1016/j.clinbiochem.2014.03.014
ER  - 

@article{
author = "Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kalimanovska-Oštrić, Dimitra and Memon, Lidija and Spasić, Slavica and Kotur-Stevuljević, Jelena and Jelić-Ivanović, Zorana",
year = "2014",
abstract = "Objectives: Epidemiological evidence concerning the role of iron, a lipid peroxidation catalyst, in atherosclerosis and coronary artery disease (CAD) is inconsistent. Design and methods: Exploratory factor analysis was used to examine the potential clustering of variables known to be associated with CAD using data from 188 patients with angiographically-approved disease. The resulting factors were then tested for their association with serum ferritin and soluble transferrin receptor (sTfR) as indicators of body iron status. Results: Factor analysis resulted in a reduction of a variable number from the original 15 to 5 composite clusters. These factors were interpreted as (1) "proatherogenic factor" with positive loadings of TC, LDL-C, apoB and TG; (2) "inflammatory factor" with positive loadings of hsCRP, fibrinogen and MDA; (3) "antiatherogenic factor" with positive loadings of HDL-C and apoA-I; (4) "obesity factor" with positive loadings of weight and waist; and (5) "antioxidative status factor" with positive loadings of SOD and age and negative loading of superoxide anion. "Inflammatory", "obesity" and "antiatherogenic" factors predicted high ferritin values and the "proatherogenic factor" predicted high sTfR values. We compared the ability of the "proatherogenic factor" with that of a multi-variable logistic model that included the "proatherogenic factor" and sTfR values in predicting significant stenosis in patients. The area under the ROC curve was 0.692 vs. 0.821, respectively. Conclusions: "Inflammatory", "obesity", "antiatherogenic" and "proatherogenic" factors were associated with increased parameters of body iron status. The measurement of sTfR improves the prediction of CAD based on clustered cardiovascular risk factors.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Factor analysis of risk variables associated with iron status in patients with coronary artery disease",
volume = "47",
number = "7-8",
pages = "564-569",
doi = "10.1016/j.clinbiochem.2014.03.014"
}

Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kalimanovska-Oštrić, D., Memon, L., Spasić, S., Kotur-Stevuljević, J.,& Jelić-Ivanović, Z.. (2014). Factor analysis of risk variables associated with iron status in patients with coronary artery disease. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 47(7-8), 564-569.
https://doi.org/10.1016/j.clinbiochem.2014.03.014

Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kalimanovska-Oštrić D, Memon L, Spasić S, Kotur-Stevuljević J, Jelić-Ivanović Z. Factor analysis of risk variables associated with iron status in patients with coronary artery disease. in Clinical Biochemistry. 2014;47(7-8):564-569.
doi:10.1016/j.clinbiochem.2014.03.014 .

Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kalimanovska-Oštrić, Dimitra, Memon, Lidija, Spasić, Slavica, Kotur-Stevuljević, Jelena, Jelić-Ivanović, Zorana, "Factor analysis of risk variables associated with iron status in patients with coronary artery disease" in Clinical Biochemistry, 47, no. 7-8 (2014):564-569,
https://doi.org/10.1016/j.clinbiochem.2014.03.014 . .

TY  - JOUR
AU  - Bojić, Suzana
AU  - Kotur-Stevuljević, Jelena
AU  - Kalezić, Nevena
AU  - Jelić-Ivanović, Zorana
AU  - Stefanović, Aleksandra
AU  - Palibrk, Ivan
AU  - Memon, Lidija
AU  - Kalaba, Zdravko
AU  - Stojanović, Marina
AU  - Simić-Ogrizović, Sanja
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2226
AB  - Introduction. State of severe oxidative stress is encountered in sepsis. Paraoxonase 1 (PON1) protects against oxidative stress but also undergoes inactivation upon that condition. We investigated PON1 activity in surgical patients with sepsis in relation to oxidative stress status, inflammation, disease severity, and survival. Methods. Prospective observational study. Sixty-nine surgical patients with sepsis were compared to 69 age/sex matched healthy controls. PON1 paraoxonase and diazoxonase activities, selected biochemical, hematological and oxidative stress parameters were measured on admission to ICU and 24, 48, 72, and 96 hours later. Disease severity scores were calculated daily. Results. Septic patients had significantly lower PON1 activities compared to control group at all time points. PON1 activities had good capacity to differentiate septic patients from healthy controls. Low PON1 activities were associated with higher disease severity scores and higher risk of death. Correlation between PON1 activity and markers of inflammation failed to reach significance. Decrease in PON1 activity was correlated with an increase in reducing components in plasma. Conclusion. Our study demonstrated lower PON1 activity in surgical patients with sepsis compared to healthy controls. PON1 activity also reflected severity of the disease. Low PON1 activity was associated with higher mortality of surgical patients with sepsis.
PB  - Hindawi Ltd, London
T2  - Disease Markers
T1  - Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis
DO  - 10.1155/2014/427378
ER  - 

@article{
author = "Bojić, Suzana and Kotur-Stevuljević, Jelena and Kalezić, Nevena and Jelić-Ivanović, Zorana and Stefanović, Aleksandra and Palibrk, Ivan and Memon, Lidija and Kalaba, Zdravko and Stojanović, Marina and Simić-Ogrizović, Sanja",
year = "2014",
abstract = "Introduction. State of severe oxidative stress is encountered in sepsis. Paraoxonase 1 (PON1) protects against oxidative stress but also undergoes inactivation upon that condition. We investigated PON1 activity in surgical patients with sepsis in relation to oxidative stress status, inflammation, disease severity, and survival. Methods. Prospective observational study. Sixty-nine surgical patients with sepsis were compared to 69 age/sex matched healthy controls. PON1 paraoxonase and diazoxonase activities, selected biochemical, hematological and oxidative stress parameters were measured on admission to ICU and 24, 48, 72, and 96 hours later. Disease severity scores were calculated daily. Results. Septic patients had significantly lower PON1 activities compared to control group at all time points. PON1 activities had good capacity to differentiate septic patients from healthy controls. Low PON1 activities were associated with higher disease severity scores and higher risk of death. Correlation between PON1 activity and markers of inflammation failed to reach significance. Decrease in PON1 activity was correlated with an increase in reducing components in plasma. Conclusion. Our study demonstrated lower PON1 activity in surgical patients with sepsis compared to healthy controls. PON1 activity also reflected severity of the disease. Low PON1 activity was associated with higher mortality of surgical patients with sepsis.",
publisher = "Hindawi Ltd, London",
journal = "Disease Markers",
title = "Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis",
doi = "10.1155/2014/427378"
}

Bojić, S., Kotur-Stevuljević, J., Kalezić, N., Jelić-Ivanović, Z., Stefanović, A., Palibrk, I., Memon, L., Kalaba, Z., Stojanović, M.,& Simić-Ogrizović, S.. (2014). Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis. in Disease Markers
Hindawi Ltd, London..
https://doi.org/10.1155/2014/427378

Bojić S, Kotur-Stevuljević J, Kalezić N, Jelić-Ivanović Z, Stefanović A, Palibrk I, Memon L, Kalaba Z, Stojanović M, Simić-Ogrizović S. Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis. in Disease Markers. 2014;.
doi:10.1155/2014/427378 .

Bojić, Suzana, Kotur-Stevuljević, Jelena, Kalezić, Nevena, Jelić-Ivanović, Zorana, Stefanović, Aleksandra, Palibrk, Ivan, Memon, Lidija, Kalaba, Zdravko, Stojanović, Marina, Simić-Ogrizović, Sanja, "Low Paraoxonase 1 Activity Predicts Mortality in Surgical Patients with Sepsis" in Disease Markers (2014),
https://doi.org/10.1155/2014/427378 . .

TY  - JOUR
AU  - Memon, Lidija
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Simić-Ogrizović, Sanja
AU  - Giga, Vojislav
AU  - Dopsaj, Violeta
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1897
AB  - BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was  lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P  lt  0.011; F = 2.631, P  lt  0.017). After adjustment for GFR, the differences were not seen. In CKD patients adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor.
PB  - Wiley, Hoboken
T2  - Journal of Clinical Laboratory Analysis
T1  - Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?
VL  - 27
IS  - 6
SP  - 461
EP  - 470
DO  - 10.1002/jcla.21628
ER  - 

@article{
author = "Memon, Lidija and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Simić-Ogrizović, Sanja and Giga, Vojislav and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Spasić, Slavica",
year = "2013",
abstract = "BackgroundThe aim of the study was to determine the clinical usefulness of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and symmetric dimethylarginine (SDMA) for detection of renal and left ventricular (LV) diastolic dysfunction in chronic kidney disease (CKD) patients and renal transplant (RT) recipients. MethodsWe included 98 CKD and 44 RT patients. We assessed LV function using pulsed-wave Doppler ultrasound. Diastolic dysfunction was defined when the E:A ratio was  lt 1. ResultsIndependent predictors of NT-proBNP levels were age, creatinine, and albumin in CKD patients and age and urea in RT patients. Determinants of SDMA in CKD patients were glomerular filtration rate (GFR) and NT-proBNP and creatinine in RT patients. In RT patients with diastolic dysfunction, NT-proBNP and SDMA were significantly higher than in patients without diastolic dysfunction (F = 7.478, P  lt  0.011; F = 2.631, P  lt  0.017). After adjustment for GFR, the differences were not seen. In CKD patients adjusted NT-proBNP and SDMA values for GFR were not significantly higher in patients with diastolic dysfunction than in patients without diastolic dysfunction. ConclusionsNT-proBNP is useful for detection of LV diastolic dysfunction in RT recipients. When evaluating both NT-proBNP and SDMA it is necessary to consider GFR as a confounding factor.",
publisher = "Wiley, Hoboken",
journal = "Journal of Clinical Laboratory Analysis",
title = "Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?",
volume = "27",
number = "6",
pages = "461-470",
doi = "10.1002/jcla.21628"
}

Memon, L., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Simić-Ogrizović, S., Giga, V., Dopsaj, V., Jelić-Ivanović, Z.,& Spasić, S.. (2013). Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?. in Journal of Clinical Laboratory Analysis
Wiley, Hoboken., 27(6), 461-470.
https://doi.org/10.1002/jcla.21628

Memon L, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kotur-Stevuljević J, Simić-Ogrizović S, Giga V, Dopsaj V, Jelić-Ivanović Z, Spasić S. Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?. in Journal of Clinical Laboratory Analysis. 2013;27(6):461-470.
doi:10.1002/jcla.21628 .

Memon, Lidija, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Simić-Ogrizović, Sanja, Giga, Vojislav, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Spasić, Slavica, "Are Levels of NT-proBNP and SDMA Useful to Determine Diastolic Dysfunction in Chronic Kidney Disease and Renal Transplant Patients?" in Journal of Clinical Laboratory Analysis, 27, no. 6 (2013):461-470,
https://doi.org/10.1002/jcla.21628 . .

TY  - JOUR
AU  - Memon, Lidija
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kotur-Stevuljević, Jelena
AU  - Simić-Ogrizović, Sanja
AU  - Giga, Vojislav
AU  - Dopsaj, Violeta
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, Slavica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1859
AB  - Objectives. The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O-2(center dot-)) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients. Materials and Methods. We included 64 CKD and 52 RT patients. Patients were stratified according to brachial artery flow-mediated dilation (FMD). Results. Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate. The ability of inflammation, SDMA, and O-2(center dot-) to detect impaired FMD was investigated by receiving operative characteristic analysis. Hs-CRP (area under the curves (AUC) = 0.754, P  lt  0.001), IL-6 (AUC = 0.699, P = 0.002), and SDMA (AUC = 0.689, P = 0.007) had the highest ability to detect impaired FMD. SDMA in combination with inflammatory parameters and/or O-2(center dot-) had better screening performance than SDMA alone. Conclusions. Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients. The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.
PB  - Hindawi Ltd, London
T2  - Disease Markers
T1  - Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients
SP  - 173
EP  - 180
DO  - 10.1155/2013/306908
ER  - 

@article{
author = "Memon, Lidija and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kotur-Stevuljević, Jelena and Simić-Ogrizović, Sanja and Giga, Vojislav and Dopsaj, Violeta and Jelić-Ivanović, Zorana and Spasić, Slavica",
year = "2013",
abstract = "Objectives. The study was designed to evaluate associations between symmetric dimethylarginine (SDMA), inflammation, and superoxide anion (O-2(center dot-)) with endothelial function and to determine their potential for screening of endothelial dysfunction in patients with chronic kidney disease (CKD) and renal transplant (RT) recipients. Materials and Methods. We included 64 CKD and 52 RT patients. Patients were stratified according to brachial artery flow-mediated dilation (FMD). Results. Logistic regression analysis showed that high SDMA and high sensitive C-reactive protein (hs-CRP) were associated with impaired FMD in CKD and RT patients, after adjustment for glomerular filtration rate. The ability of inflammation, SDMA, and O-2(center dot-) to detect impaired FMD was investigated by receiving operative characteristic analysis. Hs-CRP (area under the curves (AUC) = 0.754, P  lt  0.001), IL-6 (AUC = 0.699, P = 0.002), and SDMA (AUC = 0.689, P = 0.007) had the highest ability to detect impaired FMD. SDMA in combination with inflammatory parameters and/or O-2(center dot-) had better screening performance than SDMA alone. Conclusions. Our results indicate a strong predictable association between hs-CRP, SDMA, and endothelial dysfunction in CKD patients and RT recipients. The individual marker that showed the strongest discriminative ability for endothelial dysfunction is hs-CRP, but its usefulness as a discriminatory marker for efficient diagnosis of endothelial dysfunction should be examined in prospective studies.",
publisher = "Hindawi Ltd, London",
journal = "Disease Markers",
title = "Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients",
pages = "173-180",
doi = "10.1155/2013/306908"
}

Memon, L., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kotur-Stevuljević, J., Simić-Ogrizović, S., Giga, V., Dopsaj, V., Jelić-Ivanović, Z.,& Spasić, S.. (2013). Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. in Disease Markers
Hindawi Ltd, London., 173-180.
https://doi.org/10.1155/2013/306908

Memon L, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kotur-Stevuljević J, Simić-Ogrizović S, Giga V, Dopsaj V, Jelić-Ivanović Z, Spasić S. Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients. in Disease Markers. 2013;:173-180.
doi:10.1155/2013/306908 .

Memon, Lidija, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kotur-Stevuljević, Jelena, Simić-Ogrizović, Sanja, Giga, Vojislav, Dopsaj, Violeta, Jelić-Ivanović, Zorana, Spasić, Slavica, "Assessment of Endothelial Dysfunction: The Role of Symmetrical Dimethylarginine and Proinflammatory Markers in Chronic Kidney Disease and Renal Transplant Recipients" in Disease Markers (2013):173-180,
https://doi.org/10.1155/2013/306908 . .

TY  - JOUR
AU  - Bogavac-Stanojević, Nataša
AU  - Jelić-Ivanović, Zorana
AU  - Memon, Lidija
AU  - Zeljković, Aleksandra
AU  - Vekić, Jelena
AU  - Kotur-Stevuljević, Jelena
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2058
AB  - Prehypertension, which was defined as a systolic blood pressure (SBP) between 120 and 139 mmHg or a diastolic blood pressure (DBP) between 80 and 89 mmHg is shown to be associated with a twofold higher risk of cardiovascular disease (CVD) in addition to a higher risk of developing hypertension. We examined the association between CVD biomarkers and prehypertension in 99 adults who were free of hypertension. We measured concentrations of lipid parameters, high sensitivity serum C-reactive protein, uric acid (UA), fibrinogen and colected demografic data. The SBP positively correlated with body mass index (BMI), waist-to-hip ratio (WHR), triglycerides and UA and negatively with high density lipoprotein cholesterol and apolipoprotein A-I concentrations. There was independent association of higher WHR with higher SBP (standardized coefficients β = 0.483; p=0.002). The ordinal regression analysis revealed that WHR (β = 9.380, p =0.004) and UA concentration (β = 0.006, p = 0.013) were predictors of higher blood pressure (BP). Higher BP in asymptomatic parsons is associated with abdominal obesity. Lifestyle modifications, especially WHR reduction, should be recommended to individuals with prehypertension. Therapy with positive effect on BP and UA concentration may improve CVD management. These should be further investigated in longitudinal population-based studies.
AB  - Osobe sa sistolnim krvnim pritiskom (SKP) između 120 i 139 mm Hg i dijastolnim krvnim pritiskom (DKP) od 80 do 89 mm Hg ili sa prehipertenzijom imaju dva puta veću verovatnoću razvoja kardiovaskularnih bolesti (KVB) i veći rizik za razvoj hipertenzije. U ovoj studiji ispitivana je veza biomarkera KVB sa prehipertenzijom. U istraživanje je uključeno 99 normotenzivnih osoba. Određivane su koncentracije lipidnih parametara, visoko osetljivog C reaktivnog proteina, mokraćne kiseline (MK), fibrinogena i demografske karakteristike pacijenata. Utvrđena je pozitivna veza SKP sa indeksom telesne mase (ITM) i odnosom struka i kuka (indeks S/K) i negativna korelacija sa koncentracijama holesterola u lipoproteinima visoke gustine i apolipoproteina A-I. Takođe, visoke vrednosti indeksa S/K nezavisno od ostalih parametara doprinose povećanju SKP (standardizovani koeficijent β = 0.483; p=0.002). Veći indeks S/K (β = 9.380, p =0.004) i viša koncentracija MK (β = 0.006, p = 0.013) povećavaju verovatnoću pojave viših vrednosti krvnog pritiska (KP). Kod normotenzivnih osoba više vrednosti KP su u vezi sa abdominalnom gojaznošću, pa cilj preventivnih mera treba da bude smanjenje indeksa S/K. Buduće studije bi pored proučavanja efekata lekova na smanjenje KP, trebalo da ispitaju uticaj tih lekova na koncetraciju MK, u cilju nalaženja novih mogućnosti za smanjenje rizika za KVB.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Biomarkers of prehipertension
T1  - Biomarkeri prehipertenzije
VL  - 63
IS  - 3
SP  - 307
EP  - 318
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2058
ER  - 

@article{
author = "Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Memon, Lidija and Zeljković, Aleksandra and Vekić, Jelena and Kotur-Stevuljević, Jelena and Spasojević-Kalimanovska, Vesna",
year = "2013",
abstract = "Prehypertension, which was defined as a systolic blood pressure (SBP) between 120 and 139 mmHg or a diastolic blood pressure (DBP) between 80 and 89 mmHg is shown to be associated with a twofold higher risk of cardiovascular disease (CVD) in addition to a higher risk of developing hypertension. We examined the association between CVD biomarkers and prehypertension in 99 adults who were free of hypertension. We measured concentrations of lipid parameters, high sensitivity serum C-reactive protein, uric acid (UA), fibrinogen and colected demografic data. The SBP positively correlated with body mass index (BMI), waist-to-hip ratio (WHR), triglycerides and UA and negatively with high density lipoprotein cholesterol and apolipoprotein A-I concentrations. There was independent association of higher WHR with higher SBP (standardized coefficients β = 0.483; p=0.002). The ordinal regression analysis revealed that WHR (β = 9.380, p =0.004) and UA concentration (β = 0.006, p = 0.013) were predictors of higher blood pressure (BP). Higher BP in asymptomatic parsons is associated with abdominal obesity. Lifestyle modifications, especially WHR reduction, should be recommended to individuals with prehypertension. Therapy with positive effect on BP and UA concentration may improve CVD management. These should be further investigated in longitudinal population-based studies., Osobe sa sistolnim krvnim pritiskom (SKP) između 120 i 139 mm Hg i dijastolnim krvnim pritiskom (DKP) od 80 do 89 mm Hg ili sa prehipertenzijom imaju dva puta veću verovatnoću razvoja kardiovaskularnih bolesti (KVB) i veći rizik za razvoj hipertenzije. U ovoj studiji ispitivana je veza biomarkera KVB sa prehipertenzijom. U istraživanje je uključeno 99 normotenzivnih osoba. Određivane su koncentracije lipidnih parametara, visoko osetljivog C reaktivnog proteina, mokraćne kiseline (MK), fibrinogena i demografske karakteristike pacijenata. Utvrđena je pozitivna veza SKP sa indeksom telesne mase (ITM) i odnosom struka i kuka (indeks S/K) i negativna korelacija sa koncentracijama holesterola u lipoproteinima visoke gustine i apolipoproteina A-I. Takođe, visoke vrednosti indeksa S/K nezavisno od ostalih parametara doprinose povećanju SKP (standardizovani koeficijent β = 0.483; p=0.002). Veći indeks S/K (β = 9.380, p =0.004) i viša koncentracija MK (β = 0.006, p = 0.013) povećavaju verovatnoću pojave viših vrednosti krvnog pritiska (KP). Kod normotenzivnih osoba više vrednosti KP su u vezi sa abdominalnom gojaznošću, pa cilj preventivnih mera treba da bude smanjenje indeksa S/K. Buduće studije bi pored proučavanja efekata lekova na smanjenje KP, trebalo da ispitaju uticaj tih lekova na koncetraciju MK, u cilju nalaženja novih mogućnosti za smanjenje rizika za KVB.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Biomarkers of prehipertension, Biomarkeri prehipertenzije",
volume = "63",
number = "3",
pages = "307-318",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2058"
}

Bogavac-Stanojević, N., Jelić-Ivanović, Z., Memon, L., Zeljković, A., Vekić, J., Kotur-Stevuljević, J.,& Spasojević-Kalimanovska, V.. (2013). Biomarkers of prehipertension. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 63(3), 307-318.
https://hdl.handle.net/21.15107/rcub_farfar_2058

Bogavac-Stanojević N, Jelić-Ivanović Z, Memon L, Zeljković A, Vekić J, Kotur-Stevuljević J, Spasojević-Kalimanovska V. Biomarkers of prehipertension. in Arhiv za farmaciju. 2013;63(3):307-318.
https://hdl.handle.net/21.15107/rcub_farfar_2058 .

Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Memon, Lidija, Zeljković, Aleksandra, Vekić, Jelena, Kotur-Stevuljević, Jelena, Spasojević-Kalimanovska, Vesna, "Biomarkers of prehipertension" in Arhiv za farmaciju, 63, no. 3 (2013):307-318,
https://hdl.handle.net/21.15107/rcub_farfar_2058 .

TY  - CONF
AU  - Spasojević-Kalimanovska, Vesna
AU  - Veljić, Sandra
AU  - Kotur-Stevuljević, Jelena
AU  - Bogavac-Stanojević, Nataša
AU  - Memon, Lidija
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1396
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease
VL  - 11
IS  - 2
SP  - 161
EP  - 161
DO  - 10.1016/S1567-5688(10)70756-X
ER  - 

@conference{
author = "Spasojević-Kalimanovska, Vesna and Veljić, Sandra and Kotur-Stevuljević, Jelena and Bogavac-Stanojević, Nataša and Memon, Lidija and Kalimanovska-Oštrić, Dimitra",
year = "2010",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease",
volume = "11",
number = "2",
pages = "161-161",
doi = "10.1016/S1567-5688(10)70756-X"
}

Spasojević-Kalimanovska, V., Veljić, S., Kotur-Stevuljević, J., Bogavac-Stanojević, N., Memon, L.,& Kalimanovska-Oštrić, D.. (2010). C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 11(2), 161-161.
https://doi.org/10.1016/S1567-5688(10)70756-X

Spasojević-Kalimanovska V, Veljić S, Kotur-Stevuljević J, Bogavac-Stanojević N, Memon L, Kalimanovska-Oštrić D. C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease. in Atherosclerosis Supplements. 2010;11(2):161-161.
doi:10.1016/S1567-5688(10)70756-X .

Spasojević-Kalimanovska, Vesna, Veljić, Sandra, Kotur-Stevuljević, Jelena, Bogavac-Stanojević, Nataša, Memon, Lidija, Kalimanovska-Oštrić, Dimitra, "C-reactive protein but not soluble cd40 ligand is associated with the severity of angiographically verified coronary artery disease" in Atherosclerosis Supplements, 11, no. 2 (2010):161-161,
https://doi.org/10.1016/S1567-5688(10)70756-X . .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Memon, Lidija
AU  - Zeljković, Aleksandra
AU  - Bogavac-Stanojević, Nataša
AU  - Spasić, Slavica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1217
AB  - Elevated serum uric acid (UA) is associated with higher risk for cardiovascular disease (CVD). Smaller, denser low density lipoprotein (LDL) and high-density lipoprotein (HDL) particles are the potential risk factors for CVD, while the role and diagnostic value of inflammatory markers are firmly established. This current cross-sectional study investigates interrelationships between UA, high sensitivity C-reactive protein (hsCRP) and fibrinogen concentrations with LDL and HDL sizes in healthy middle-aged subjects. The outcomes-of-interest were smaller, denser LDL and HDL particles (LDL size  lt = 25.5 nm and HDL size  lt = 8.8 nm). Serum UA, hsCRP and plasma fibrinogen concentrations were measured by standard laboratory methods in a sample of 194 healthy volunteers (112 men and 82 women). LDL and HDL particle sizes were determined by gradient gel electrophoresis. The subjects in the highest UA tertile had significantly smaller LDL and HDL particle sizes (P  lt  0.05 and P  lt  0.01, respectively) and higher concentrations of fibrinogen and hsCRP (P  lt  0.05 and P  lt  0.01, respectively). Elevated UA (>= 318 mu mol/L) was a significant predictor of smaller, denser LDL and HDL particles (OR = 3.09; P  lt  0.01; n = 19 and OR = 4.40: P  lt  0.001; n = 23, respectively). The observed relationship with smaller HDL size persisted after adjustment for conventional cardiovascular risk factors. UA strongly correlated with both markers of inflammation. In addition, the higher hsCRP level correlated with smaller LDL size (P  lt  0.05), while fibrinogen concentration was inversely related to HDL size (P lt 0.05). Multiple regression analysis revealed that HDL size and inflammatory markers remained independent determinants of UA concentration. In conclusion, higher serum UA and low-grade inflammation are closely linked to alterations in lipoprotein metabolism which may represent an early sign of atherosclerosis in asymptomatic subjects.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles
VL  - 203
IS  - 1
SP  - 236
EP  - 242
DO  - 10.1016/j.atherosclerosis.2008.05.047
ER  - 

@article{
author = "Vekić, Jelena and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Memon, Lidija and Zeljković, Aleksandra and Bogavac-Stanojević, Nataša and Spasić, Slavica",
year = "2009",
abstract = "Elevated serum uric acid (UA) is associated with higher risk for cardiovascular disease (CVD). Smaller, denser low density lipoprotein (LDL) and high-density lipoprotein (HDL) particles are the potential risk factors for CVD, while the role and diagnostic value of inflammatory markers are firmly established. This current cross-sectional study investigates interrelationships between UA, high sensitivity C-reactive protein (hsCRP) and fibrinogen concentrations with LDL and HDL sizes in healthy middle-aged subjects. The outcomes-of-interest were smaller, denser LDL and HDL particles (LDL size  lt = 25.5 nm and HDL size  lt = 8.8 nm). Serum UA, hsCRP and plasma fibrinogen concentrations were measured by standard laboratory methods in a sample of 194 healthy volunteers (112 men and 82 women). LDL and HDL particle sizes were determined by gradient gel electrophoresis. The subjects in the highest UA tertile had significantly smaller LDL and HDL particle sizes (P  lt  0.05 and P  lt  0.01, respectively) and higher concentrations of fibrinogen and hsCRP (P  lt  0.05 and P  lt  0.01, respectively). Elevated UA (>= 318 mu mol/L) was a significant predictor of smaller, denser LDL and HDL particles (OR = 3.09; P  lt  0.01; n = 19 and OR = 4.40: P  lt  0.001; n = 23, respectively). The observed relationship with smaller HDL size persisted after adjustment for conventional cardiovascular risk factors. UA strongly correlated with both markers of inflammation. In addition, the higher hsCRP level correlated with smaller LDL size (P  lt  0.05), while fibrinogen concentration was inversely related to HDL size (P lt 0.05). Multiple regression analysis revealed that HDL size and inflammatory markers remained independent determinants of UA concentration. In conclusion, higher serum UA and low-grade inflammation are closely linked to alterations in lipoprotein metabolism which may represent an early sign of atherosclerosis in asymptomatic subjects.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles",
volume = "203",
number = "1",
pages = "236-242",
doi = "10.1016/j.atherosclerosis.2008.05.047"
}

Vekić, J., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Memon, L., Zeljković, A., Bogavac-Stanojević, N.,& Spasić, S.. (2009). High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 203(1), 236-242.
https://doi.org/10.1016/j.atherosclerosis.2008.05.047

Vekić J, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Memon L, Zeljković A, Bogavac-Stanojević N, Spasić S. High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles. in Atherosclerosis. 2009;203(1):236-242.
doi:10.1016/j.atherosclerosis.2008.05.047 .

Vekić, Jelena, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Memon, Lidija, Zeljković, Aleksandra, Bogavac-Stanojević, Nataša, Spasić, Slavica, "High serum uric acid and low-grade inflammation are associated with smaller LDL and HDL particles" in Atherosclerosis, 203, no. 1 (2009):236-242,
https://doi.org/10.1016/j.atherosclerosis.2008.05.047 . .

TY  - JOUR
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Memon, Lidija
AU  - Spasić, Slavica
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1186
AB  - Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P  lt  0.001) and sdLDL-apoB concentrations (P  lt  0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was associated with higher concentrations of both sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P  lt  0.01) and sdLDL-apoB concentrations (P  lt  0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size
VL  - 207
IS  - 2
SP  - 496
EP  - 501
DO  - 10.1016/j.atherosclerosis.2009.06.035
ER  - 

@article{
author = "Vekić, Jelena and Zeljković, Aleksandra and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Memon, Lidija and Spasić, Slavica",
year = "2009",
abstract = "Objective: Small, dense low-density lipoprotein-cholesterol (sdLDL-C) is a recently recognised marker of cardiovascular disease risk. On the other hand, the usefulness of sdLDL-apoB concentration determination in clinical practice offers grounds for further exploration. This study investigates the associations of sdLDL-C and sdLDL-apoB with serum lipid parameters and LDL size in healthy men and women. Methods: The concentrations of sdLDL-C and sdLDL-apoB were measured after heparin-magnesium precipitation of serum samples from ninety-five asymptomatic subjects (47 men, 30 premenopausal and 18 menopausal women). LDL size was determined by gradient gel electrophoresis and serum lipid and lipoprotein parameters were measured by routine laboratory methods. Results: Compared to premenopausal women, men had higher sdLDL-C (P  lt  0.001) and sdLDL-apoB concentrations (P  lt  0.001). No difference in the sdLDL-C concentration was found between men and menopausal women. Menopause status was associated with higher concentrations of both sdLDL-C (P  lt  0.01) and sdLDL-apoB (P  lt  0.05). Subjects with the LDL B phenotype had elevated sdLDL-C (P  lt  0.01) and sdLDL-apoB concentrations (P  lt  0.001). LDL size and triglycerides were independent determinants of both sdLDL-C and sdLDL-apoB concentrations. Conclusion: Gender and menopausal status have significant impact on sdLDL-C and sdLDL-apoB concentrations. The variability in sdLDL-C and sdLDL-apoB levels is considerably influenced by changes in LDL size and triglyceride concentration. Our results suggest that the characterisation of sdLDL particles by evaluating sdLDL-C could be complemented with sdLDL-apoB determination.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size",
volume = "207",
number = "2",
pages = "496-501",
doi = "10.1016/j.atherosclerosis.2009.06.035"
}

Vekić, J., Zeljković, A., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Memon, L.,& Spasić, S.. (2009). Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 207(2), 496-501.
https://doi.org/10.1016/j.atherosclerosis.2009.06.035

Vekić J, Zeljković A, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Memon L, Spasić S. Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size. in Atherosclerosis. 2009;207(2):496-501.
doi:10.1016/j.atherosclerosis.2009.06.035 .

Vekić, Jelena, Zeljković, Aleksandra, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Memon, Lidija, Spasić, Slavica, "Small, dense LDL cholesterol and apolipoprotein B: Relationship with serum lipids and LDL size" in Atherosclerosis, 207, no. 2 (2009):496-501,
https://doi.org/10.1016/j.atherosclerosis.2009.06.035 . .

TY  - CONF
AU  - Jelić-Ivanović, Zorana
AU  - Bogavac-Stanojević, Nataša
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, S.
AU  - Memon, Lidija
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1057
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development
VL  - 9
IS  - 1
SP  - 107
EP  - 107
DO  - 10.1016/S1567-5688(08)70428-8
ER  - 

@conference{
author = "Jelić-Ivanović, Zorana and Bogavac-Stanojević, Nataša and Spasojević-Kalimanovska, Vesna and Spasić, S. and Memon, Lidija and Kalimanovska-Oštrić, Dimitra",
year = "2008",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development",
volume = "9",
number = "1",
pages = "107-107",
doi = "10.1016/S1567-5688(08)70428-8"
}

Jelić-Ivanović, Z., Bogavac-Stanojević, N., Spasojević-Kalimanovska, V., Spasić, S., Memon, L.,& Kalimanovska-Oštrić, D.. (2008). Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 9(1), 107-107.
https://doi.org/10.1016/S1567-5688(08)70428-8

Jelić-Ivanović Z, Bogavac-Stanojević N, Spasojević-Kalimanovska V, Spasić S, Memon L, Kalimanovska-Oštrić D. Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development. in Atherosclerosis Supplements. 2008;9(1):107-107.
doi:10.1016/S1567-5688(08)70428-8 .

Jelić-Ivanović, Zorana, Bogavac-Stanojević, Nataša, Spasojević-Kalimanovska, Vesna, Spasić, S., Memon, Lidija, Kalimanovska-Oštrić, Dimitra, "Effects of apolipoprotein(a) size polymorphism and lipoprotein(a) concetrations combinedwith other risk factors on cad development" in Atherosclerosis Supplements, 9, no. 1 (2008):107-107,
https://doi.org/10.1016/S1567-5688(08)70428-8 . .

TY  - CONF
AU  - Bogavac-Stanojević, Nataša
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Spasić, S.
AU  - Memon, Lidija
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1045
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Impact of apolipoprotein(a) isoforms on plasma lipoprotein(a) concentrations and their association with coronary artery disease
VL  - 9
IS  - 1
SP  - 113
EP  - 114
DO  - 10.1016/S1567-5688(08)70456-2
ER  - 

@conference{
author = "Bogavac-Stanojević, Nataša and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Spasić, S. and Memon, Lidija",
year = "2008",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Impact of apolipoprotein(a) isoforms on plasma lipoprotein(a) concentrations and their association with coronary artery disease",
volume = "9",
number = "1",
pages = "113-114",
doi = "10.1016/S1567-5688(08)70456-2"
}

Bogavac-Stanojević, N., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Spasić, S.,& Memon, L.. (2008). Impact of apolipoprotein(a) isoforms on plasma lipoprotein(a) concentrations and their association with coronary artery disease. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 9(1), 113-114.
https://doi.org/10.1016/S1567-5688(08)70456-2

Bogavac-Stanojević N, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Spasić S, Memon L. Impact of apolipoprotein(a) isoforms on plasma lipoprotein(a) concentrations and their association with coronary artery disease. in Atherosclerosis Supplements. 2008;9(1):113-114.
doi:10.1016/S1567-5688(08)70456-2 .

Bogavac-Stanojević, Nataša, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Spasić, S., Memon, Lidija, "Impact of apolipoprotein(a) isoforms on plasma lipoprotein(a) concentrations and their association with coronary artery disease" in Atherosclerosis Supplements, 9, no. 1 (2008):113-114,
https://doi.org/10.1016/S1567-5688(08)70456-2 . .

TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Spasić, Slavica
AU  - Jelić-Ivanović, Zorana
AU  - Spasojević-Kalimanovska, Vesna
AU  - Stefanović, Aleksandra
AU  - Vujović, Ana
AU  - Memon, Lidija
AU  - Kalimanovska-Oštrić, Dimitra
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1119
AB  - Objectives: High-density lipoprotein (HDL) associated paraoxonase. 1 (PON1) is an essential component of HDLs' capability to protect low-density lipoproteins (LDL) from oxidative modification and thus to limit the atherosclerotic process. The aim of the Current Study was to investigate the association between oxidative stress status, indices of inflammation and PON1 status parameters. Design and methods: We determined the relationship between the oxidative stress status, inflammatory markers and PON1 status parameters in 261 middle-aged subjects: 156 coronary heart disease (CHD) patients and 105 CHD-free subjects (as the control group). The PON1 status involved PON1 activity measurements towards two substrates: paraoxon (POase activity) and diazoxon (DZOase activity) and subsequent PON1(Q192R) activity phenotype determination. Results: A statistically significant greater malondialdehyde (MDA) concentration in the RR phenotype subjects compared to QQ subjects within the CHD group was apparent (P lt 0.05). Multiple linear regression analysis revealed an independent influence of plasmatic SOD activity (P lt 0.05) on POase values and MDA (P lt 0.01) and O-2(center dot-) (P lt 0.05) on DZOase values. Involvement of inflammatory markers (fibrinogen and hsCRP) in the regression model did not hinder the influence of SOD and MDA on POase and DZOase activities, respectively. Conclusions: Our CHD patients were in a state of oxidative stress, which was most evident in the RR phenotype group. The QQ phenotype group is associated with the lowest oxidative stress status level and also with a better capacity for anti-oxidative protection. Oxidative stress in CHD patients is maintained by systemic low-grade inflammation which results in PON1 enzymatic activity exhaustion. Therefore, deeper investigation of an effective anti-oxidative and anti-inflammatory therapy should be necessary in order to increase anti-oxidative potency and improve PON1 status of CHD patients.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients
VL  - 41
IS  - 13
SP  - 1067
EP  - 1073
DO  - 10.1016/j.clinbiochem.2008.06.009
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Spasić, Slavica and Jelić-Ivanović, Zorana and Spasojević-Kalimanovska, Vesna and Stefanović, Aleksandra and Vujović, Ana and Memon, Lidija and Kalimanovska-Oštrić, Dimitra",
year = "2008",
abstract = "Objectives: High-density lipoprotein (HDL) associated paraoxonase. 1 (PON1) is an essential component of HDLs' capability to protect low-density lipoproteins (LDL) from oxidative modification and thus to limit the atherosclerotic process. The aim of the Current Study was to investigate the association between oxidative stress status, indices of inflammation and PON1 status parameters. Design and methods: We determined the relationship between the oxidative stress status, inflammatory markers and PON1 status parameters in 261 middle-aged subjects: 156 coronary heart disease (CHD) patients and 105 CHD-free subjects (as the control group). The PON1 status involved PON1 activity measurements towards two substrates: paraoxon (POase activity) and diazoxon (DZOase activity) and subsequent PON1(Q192R) activity phenotype determination. Results: A statistically significant greater malondialdehyde (MDA) concentration in the RR phenotype subjects compared to QQ subjects within the CHD group was apparent (P lt 0.05). Multiple linear regression analysis revealed an independent influence of plasmatic SOD activity (P lt 0.05) on POase values and MDA (P lt 0.01) and O-2(center dot-) (P lt 0.05) on DZOase values. Involvement of inflammatory markers (fibrinogen and hsCRP) in the regression model did not hinder the influence of SOD and MDA on POase and DZOase activities, respectively. Conclusions: Our CHD patients were in a state of oxidative stress, which was most evident in the RR phenotype group. The QQ phenotype group is associated with the lowest oxidative stress status level and also with a better capacity for anti-oxidative protection. Oxidative stress in CHD patients is maintained by systemic low-grade inflammation which results in PON1 enzymatic activity exhaustion. Therefore, deeper investigation of an effective anti-oxidative and anti-inflammatory therapy should be necessary in order to increase anti-oxidative potency and improve PON1 status of CHD patients.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients",
volume = "41",
number = "13",
pages = "1067-1073",
doi = "10.1016/j.clinbiochem.2008.06.009"
}

Kotur-Stevuljević, J., Spasić, S., Jelić-Ivanović, Z., Spasojević-Kalimanovska, V., Stefanović, A., Vujović, A., Memon, L.,& Kalimanovska-Oštrić, D.. (2008). PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 41(13), 1067-1073.
https://doi.org/10.1016/j.clinbiochem.2008.06.009

Kotur-Stevuljević J, Spasić S, Jelić-Ivanović Z, Spasojević-Kalimanovska V, Stefanović A, Vujović A, Memon L, Kalimanovska-Oštrić D. PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients. in Clinical Biochemistry. 2008;41(13):1067-1073.
doi:10.1016/j.clinbiochem.2008.06.009 .

Kotur-Stevuljević, Jelena, Spasić, Slavica, Jelić-Ivanović, Zorana, Spasojević-Kalimanovska, Vesna, Stefanović, Aleksandra, Vujović, Ana, Memon, Lidija, Kalimanovska-Oštrić, Dimitra, "PON1 status is influenced by oxidative stress and inflammation in coronary heart disease patients" in Clinical Biochemistry, 41, no. 13 (2008):1067-1073,
https://doi.org/10.1016/j.clinbiochem.2008.06.009 . .

TY  - CONF
AU  - Topić, Aleksandra
AU  - Spasojević-Kalimanovska, Vesna
AU  - Veselinović, S.
AU  - Jelić-Ivanović, Zorana
AU  - Spasić, S.
AU  - Memon, Lidija
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/931
PB  - Elsevier Ireland Ltd, Clare
C3  - Atherosclerosis Supplements
T1  - Apolipoprotein E polymorphism in the Serbian general population and effect on lipid parameters in the middle-aged subjects
VL  - 8
IS  - 1
SP  - 36
EP  - 36
DO  - 10.1016/S1567-5688(07)71086-3
ER  - 

@conference{
author = "Topić, Aleksandra and Spasojević-Kalimanovska, Vesna and Veselinović, S. and Jelić-Ivanović, Zorana and Spasić, S. and Memon, Lidija",
year = "2007",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis Supplements",
title = "Apolipoprotein E polymorphism in the Serbian general population and effect on lipid parameters in the middle-aged subjects",
volume = "8",
number = "1",
pages = "36-36",
doi = "10.1016/S1567-5688(07)71086-3"
}

Topić, A., Spasojević-Kalimanovska, V., Veselinović, S., Jelić-Ivanović, Z., Spasić, S.,& Memon, L.. (2007). Apolipoprotein E polymorphism in the Serbian general population and effect on lipid parameters in the middle-aged subjects. in Atherosclerosis Supplements
Elsevier Ireland Ltd, Clare., 8(1), 36-36.
https://doi.org/10.1016/S1567-5688(07)71086-3

Topić A, Spasojević-Kalimanovska V, Veselinović S, Jelić-Ivanović Z, Spasić S, Memon L. Apolipoprotein E polymorphism in the Serbian general population and effect on lipid parameters in the middle-aged subjects. in Atherosclerosis Supplements. 2007;8(1):36-36.
doi:10.1016/S1567-5688(07)71086-3 .

Topić, Aleksandra, Spasojević-Kalimanovska, Vesna, Veselinović, S., Jelić-Ivanović, Zorana, Spasić, S., Memon, Lidija, "Apolipoprotein E polymorphism in the Serbian general population and effect on lipid parameters in the middle-aged subjects" in Atherosclerosis Supplements, 8, no. 1 (2007):36-36,
https://doi.org/10.1016/S1567-5688(07)71086-3 . .

TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Memon, Lidija
AU  - Stefanović, Aleksandra
AU  - Spasić, Slavica
AU  - Spasojević-Kalimanovska, Vesna
AU  - Bogavac-Stanojević, Nataša
AU  - Kalimanovska-Oštrić, Dimitra
AU  - Jelić-Ivanović, Zorana
AU  - Zunić, Gordana
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/947
AB  - Objectives: In addition to many traditional risk factors for coronary artery disease (CAD) development, enhanced oxidative stress and inflammation are serious conditions that may also be classified as novel risk factors. In the present study, we assessed the relationship between several parameters of oxidative stress status [malonaldehyde (MDA), superoxide anion (O-2(center dot)-) and plasma and erythrocyte superoxide dismutase (SOD) activities] with high sensitivity C-reactive protein (hsCRP) and fibrinogen as inflammation markers. Design and methods: Oxidative stress status parameters, inflammation markers and lipid status parameters were measured in 385 subjects [188 coronary heart disease (CHD) patients with angiographically diagnosed coronary artery disease (CAD), 141 patients with occlusion > 50% in at least one major coronary artery (CAD+) and 47 patients with occlusion less than 50% (CAD-), and 197 CHD-free middle-aged subjects (the control group)]. Results: The plasma MDA concentration and the level of O-2(center dot)- in plasma were significantly higher in combination with significantly lower SOD activity in the CAD+ group vs. the control group. By using multiple stepwise regression analysis, fibrinogen and hsCRP showed independent correlation with MDA. Binary logistic regression analysis indicated that both MDA and O-2(center dot)- were significantly associated with CAD development and adjustment for inflammatory markers weakened this association in the case of MDA. Conclusions: The relationship between oxidative stress parameters and inflammatory species suggest their strong mutual involvement in atherosclerosis development that leads to CAD progression.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients
VL  - 40
IS  - 3-4
SP  - 181
EP  - 187
DO  - 10.1016/j.clinbiochem.2006.09.007
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Memon, Lidija and Stefanović, Aleksandra and Spasić, Slavica and Spasojević-Kalimanovska, Vesna and Bogavac-Stanojević, Nataša and Kalimanovska-Oštrić, Dimitra and Jelić-Ivanović, Zorana and Zunić, Gordana",
year = "2007",
abstract = "Objectives: In addition to many traditional risk factors for coronary artery disease (CAD) development, enhanced oxidative stress and inflammation are serious conditions that may also be classified as novel risk factors. In the present study, we assessed the relationship between several parameters of oxidative stress status [malonaldehyde (MDA), superoxide anion (O-2(center dot)-) and plasma and erythrocyte superoxide dismutase (SOD) activities] with high sensitivity C-reactive protein (hsCRP) and fibrinogen as inflammation markers. Design and methods: Oxidative stress status parameters, inflammation markers and lipid status parameters were measured in 385 subjects [188 coronary heart disease (CHD) patients with angiographically diagnosed coronary artery disease (CAD), 141 patients with occlusion > 50% in at least one major coronary artery (CAD+) and 47 patients with occlusion less than 50% (CAD-), and 197 CHD-free middle-aged subjects (the control group)]. Results: The plasma MDA concentration and the level of O-2(center dot)- in plasma were significantly higher in combination with significantly lower SOD activity in the CAD+ group vs. the control group. By using multiple stepwise regression analysis, fibrinogen and hsCRP showed independent correlation with MDA. Binary logistic regression analysis indicated that both MDA and O-2(center dot)- were significantly associated with CAD development and adjustment for inflammatory markers weakened this association in the case of MDA. Conclusions: The relationship between oxidative stress parameters and inflammatory species suggest their strong mutual involvement in atherosclerosis development that leads to CAD progression.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients",
volume = "40",
number = "3-4",
pages = "181-187",
doi = "10.1016/j.clinbiochem.2006.09.007"
}

Kotur-Stevuljević, J., Memon, L., Stefanović, A., Spasić, S., Spasojević-Kalimanovska, V., Bogavac-Stanojević, N., Kalimanovska-Oštrić, D., Jelić-Ivanović, Z.,& Zunić, G.. (2007). Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 40(3-4), 181-187.
https://doi.org/10.1016/j.clinbiochem.2006.09.007

Kotur-Stevuljević J, Memon L, Stefanović A, Spasić S, Spasojević-Kalimanovska V, Bogavac-Stanojević N, Kalimanovska-Oštrić D, Jelić-Ivanović Z, Zunić G. Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients. in Clinical Biochemistry. 2007;40(3-4):181-187.
doi:10.1016/j.clinbiochem.2006.09.007 .

Kotur-Stevuljević, Jelena, Memon, Lidija, Stefanović, Aleksandra, Spasić, Slavica, Spasojević-Kalimanovska, Vesna, Bogavac-Stanojević, Nataša, Kalimanovska-Oštrić, Dimitra, Jelić-Ivanović, Zorana, Zunić, Gordana, "Correlation of oxidative stress parameters and inflammatory markers in coronary artery disease patients" in Clinical Biochemistry, 40, no. 3-4 (2007):181-187,
https://doi.org/10.1016/j.clinbiochem.2006.09.007 . .

TY  - CONF
AU  - Bogavac-Stanojević, Nataša
AU  - Petrova, Guenka
AU  - Jelić-Ivanović, Zorana
AU  - Memon, Lidija
AU  - Spasić, Slavica
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/900
AB  - OBJECTIVES: The aim of this study was to analyse the cost-
effectiveness of consecutive supplementing of the Framingham
scoring (FRS) algorithm for coronary artery disease (CAD) risk
assessment with apolipoproteins B and A-I (apoA-I and apoB),
the apo (a) phenotype, lipoprotein (a), and high sensitivity C-
reactive protein (hs-CRP). The perspective of the analysis is the
clinical laboratory setting. METHODS: The study is prospective
diagnosing of 221 CAD patients and 289 controls. First line
testing followed the guidelines for risk assessment based on FRS.
Risk factors included in the FRS are: age, total cholesterol, high
density cholesterol, systolic blood pressure, treatment for hyper-
tension and cigarette smoking. FRS classifies individuals into
those with 10-year risk for CAD of >20% event risk (high risk
group), 10–20% event risk (intermediate risk group) and <10%
event risk (low risk group). The FRS algorithm was supple-
mented with apolipoproteins, lipoproteins and hs-CRP and the
effectiveness was measured in number needed to diagnose
(NND). Total cost of diagnostic procedure was calculated on the
basis of the consumed resources for diagnostic tests, labor time,
and consumables. To evaluate the additional number needed to
be diagnosed for successful CAD risk establishment was per-
formed and incremental cost-effectiveness analysis. RESULTS:
A diagnostic strategy employing FRS followed by apoA-I had
lowest cost per additionally successfully diagnoses patient than
the same strategy followed by hs-CRP in the low (2.63 vs. 24.47
euros) and intermediate risk groups (2.93 vs. 122.86 euros). In
the high-risk group the diagnostic strategy employing apo A-I
was the cost-effective strategy. It had a lower ICER (-9.14 euros)
than the strategy employing hs-CRP (7.16 euros). CONCLUSION: Cost-effectiveness analysis of different diagnostic markers
results in improved identification of at-risk patients at a lower
health cost for society. In the clinical laboratory setting it is
sufficient to determine apoA-I concentration in addition to FRS
for CAD risk assessment.
PB  - Elsevier
C3  - Value in Health
T1  - The cost-effectiveness analysis of coronary artery disease diagnostic parameters in a clinical laboratory setting
VL  - 10
IS  - 6
SP  - A414
EP  - A414
DO  - 10.1016/S1098-3015(10)65444-7
ER  - 

@conference{
author = "Bogavac-Stanojević, Nataša and Petrova, Guenka and Jelić-Ivanović, Zorana and Memon, Lidija and Spasić, Slavica",
year = "2007",
abstract = "OBJECTIVES: The aim of this study was to analyse the cost-
effectiveness of consecutive supplementing of the Framingham
scoring (FRS) algorithm for coronary artery disease (CAD) risk
assessment with apolipoproteins B and A-I (apoA-I and apoB),
the apo (a) phenotype, lipoprotein (a), and high sensitivity C-
reactive protein (hs-CRP). The perspective of the analysis is the
clinical laboratory setting. METHODS: The study is prospective
diagnosing of 221 CAD patients and 289 controls. First line
testing followed the guidelines for risk assessment based on FRS.
Risk factors included in the FRS are: age, total cholesterol, high
density cholesterol, systolic blood pressure, treatment for hyper-
tension and cigarette smoking. FRS classifies individuals into
those with 10-year risk for CAD of >20% event risk (high risk
group), 10–20% event risk (intermediate risk group) and <10%
event risk (low risk group). The FRS algorithm was supple-
mented with apolipoproteins, lipoproteins and hs-CRP and the
effectiveness was measured in number needed to diagnose
(NND). Total cost of diagnostic procedure was calculated on the
basis of the consumed resources for diagnostic tests, labor time,
and consumables. To evaluate the additional number needed to
be diagnosed for successful CAD risk establishment was per-
formed and incremental cost-effectiveness analysis. RESULTS:
A diagnostic strategy employing FRS followed by apoA-I had
lowest cost per additionally successfully diagnoses patient than
the same strategy followed by hs-CRP in the low (2.63 vs. 24.47
euros) and intermediate risk groups (2.93 vs. 122.86 euros). In
the high-risk group the diagnostic strategy employing apo A-I
was the cost-effective strategy. It had a lower ICER (-9.14 euros)
than the strategy employing hs-CRP (7.16 euros). CONCLUSION: Cost-effectiveness analysis of different diagnostic markers
results in improved identification of at-risk patients at a lower
health cost for society. In the clinical laboratory setting it is
sufficient to determine apoA-I concentration in addition to FRS
for CAD risk assessment.",
publisher = "Elsevier",
journal = "Value in Health",
title = "The cost-effectiveness analysis of coronary artery disease diagnostic parameters in a clinical laboratory setting",
volume = "10",
number = "6",
pages = "A414-A414",
doi = "10.1016/S1098-3015(10)65444-7"
}

Bogavac-Stanojević, N., Petrova, G., Jelić-Ivanović, Z., Memon, L.,& Spasić, S.. (2007). The cost-effectiveness analysis of coronary artery disease diagnostic parameters in a clinical laboratory setting. in Value in Health
Elsevier., 10(6), A414-A414.
https://doi.org/10.1016/S1098-3015(10)65444-7

Bogavac-Stanojević N, Petrova G, Jelić-Ivanović Z, Memon L, Spasić S. The cost-effectiveness analysis of coronary artery disease diagnostic parameters in a clinical laboratory setting. in Value in Health. 2007;10(6):A414-A414.
doi:10.1016/S1098-3015(10)65444-7 .

Bogavac-Stanojević, Nataša, Petrova, Guenka, Jelić-Ivanović, Zorana, Memon, Lidija, Spasić, Slavica, "The cost-effectiveness analysis of coronary artery disease diagnostic parameters in a clinical laboratory setting" in Value in Health, 10, no. 6 (2007):A414-A414,
https://doi.org/10.1016/S1098-3015(10)65444-7 . .