TY  - JOUR
AU  - Pavlović, Miloš
AU  - Đukić, Mirjana
AU  - Vojvodić, Danilo
AU  - Ninković, Milica
AU  - Stevanović, Ivana
AU  - Đurić, Ana
AU  - Stanojević, Boban
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3956
AB  - Background/Aim. Exposure  of  living  organisms  to  γ- radiation results in the overproduction of free radicals. The  aim of the study was to test if the subacute administration  of micronized zeolite (MZC) accomplishes radioprotective  role based on the evaluation of the status of oxidative stress  (OS) in the brain and 8-hydroxyguanosine (8-OH-dG)  in  the plasma of the rats exposed to the single γ-ray irradiation  of 2 and/or 10 Gray (Gy). Methods. Wistar rats were on a  four-week normal or 5% MZC supplemented diet and af- terward exposed to the single γ-ray irradiation  of 2 and 10  Gy. Groups of rats were: a) on a normal diet (the control  group, and 2Gy and 10Gy groups); b) on 5% MZC supple- mented diet (the control group –  MZC, MZC  +  2Gy, and  MZC + 10Gy  groups).  We  measured  malondialdehyde  (MDA), glutathione (GSH) total, and activity of total super- oxide  dismutase  (tSOD)  and  manganese  superoxide  dis- mutase (MnSOD)  in vulnerable brain regions (cerebellum,  hippocampus, and cerebral cortex) and 8-OH-dG in plasma.  Results.  Lower MDA was found in the MZC+2Gy and  MZC+10Gy  groups  compared  to  the  2Gy  and  10Gy  groups.  Activity  od  total  SOD  was  higher  in  the  MZC+10Gy group  than in the 10Gy  one. GSH was the  highest in the 10Gy group. Compared to the control group,  8-OH-dG was extremely higher in groups radiated with 10  Gy regardless of a diet, but slightly lower in the MZC+2Gy  and 2Gy groups. Conclusion. Subacute MZC pretreatment  accomplished partial radioprotective effect in irradiated rats  compared to non-irradiated rats, based on suppressed SOD  activity at 2 Gy, and reduced brain MDA when exposed to 2  Gy and 10 Gy.
AB  - Uvod/Cilj.  Izlaganje živih organizama gama zračenju re- zultira hiperprodukcijom slobodnih radikala. Cilj istraživanja  je bio da se ispita da li subakutna ishrana  dopunjena  sa 5%  mikronizovanog zeolita (MZC) ispoljava radiozaštitnu ulogu  na osnovu statusa oksidativnog stresa (OS) u mozgu i 8- hidroksiguanozina  (8-OH-dG)  u  plazmi  pacova  izloženih  pojedinačnim dozama jonizujućeg zračenja od 2 i 10 Gray  (Gy).  Metode.  Wistar  pacovi  su  bili  na  četvoronedeljnoj  normalnoj ishrani ili ishrani obogaćenoj sa 5% MZC, posle  čega su bili izloženi pojedinačnom jonizujućem zračenju od  2  Gy,  odnosno  10  Gy.  Grupe  pacova  bile  su:  a)  gru pa  pacova na normalnoj ishrani (kontrolna grupa i grupe 2Gy i  10Gy); b) grupa pacova na ishrani obogaćenoj sa 5%  MZC  (kontrolna  grupa  – MZC  i  grupe  MZC+2Gy  i   MZC+10Gy).  Meren  je  malondialdehid  (MDA),  glutation  (GSH)  i  aktivnost  ukupne  (tSOD)  i  mangan  superoksid  dizmutaze  (MnSOD)  u  osetljivim  strukturama  mozga  (cerebelum, hipokampus i cerebralni korteks), a 8-OH-dG u  plazmi.  Rezultati. Biomarker  MDA  je  bio  niži  u  MZC+2Gy i MZC+10Gy grupama, u odnosu na grupe 2Gy  i  10Gy.  Aktivnost  ukupne SOD  je  bila  viša  u  grupi  MZC+10Gy, u odnosu na grupu 10Gy. Najviši nivo GSH  bio je u grupi 10Gy. U pređenju sa kontrolnom grupom, 8- OH-dG je bio izuzetno viši u grupama ozračenim sa 10 Gy,  bez obzira na dijetetski režim i niži u grupama MZC+2Gy i  2Gy.  Zaključak. Pacovi  koji  su  bili  na  režimu  ishrane  obogaćene  sa  5%  MZC  bili  su  delimično  zaštićeni  od  zračenja, shodno redukovanoj moždanoj aktivnosti SOD pri  2  Gy i sniženom nivou MDA pri izlaganju zračenju od 2 i  10 Gy.
PB  - Belgrade: Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T1  - Moderate radioprotective role of zeolite in rats
T1  - Umerena radioprotektivna uloga zeolita kod pacova
VL  - 78
IS  - 7
SP  - 760
EP  - 768
DO  - 10.2298/VSP190702136P
ER  - 

@article{
author = "Pavlović, Miloš and Đukić, Mirjana and Vojvodić, Danilo and Ninković, Milica and Stevanović, Ivana and Đurić, Ana and Stanojević, Boban",
year = "2021",
abstract = "Background/Aim. Exposure  of  living  organisms  to  γ- radiation results in the overproduction of free radicals. The  aim of the study was to test if the subacute administration  of micronized zeolite (MZC) accomplishes radioprotective  role based on the evaluation of the status of oxidative stress  (OS) in the brain and 8-hydroxyguanosine (8-OH-dG)  in  the plasma of the rats exposed to the single γ-ray irradiation  of 2 and/or 10 Gray (Gy). Methods. Wistar rats were on a  four-week normal or 5% MZC supplemented diet and af- terward exposed to the single γ-ray irradiation  of 2 and 10  Gy. Groups of rats were: a) on a normal diet (the control  group, and 2Gy and 10Gy groups); b) on 5% MZC supple- mented diet (the control group –  MZC, MZC  +  2Gy, and  MZC + 10Gy  groups).  We  measured  malondialdehyde  (MDA), glutathione (GSH) total, and activity of total super- oxide  dismutase  (tSOD)  and  manganese  superoxide  dis- mutase (MnSOD)  in vulnerable brain regions (cerebellum,  hippocampus, and cerebral cortex) and 8-OH-dG in plasma.  Results.  Lower MDA was found in the MZC+2Gy and  MZC+10Gy  groups  compared  to  the  2Gy  and  10Gy  groups.  Activity  od  total  SOD  was  higher  in  the  MZC+10Gy group  than in the 10Gy  one. GSH was the  highest in the 10Gy group. Compared to the control group,  8-OH-dG was extremely higher in groups radiated with 10  Gy regardless of a diet, but slightly lower in the MZC+2Gy  and 2Gy groups. Conclusion. Subacute MZC pretreatment  accomplished partial radioprotective effect in irradiated rats  compared to non-irradiated rats, based on suppressed SOD  activity at 2 Gy, and reduced brain MDA when exposed to 2  Gy and 10 Gy., Uvod/Cilj.  Izlaganje živih organizama gama zračenju re- zultira hiperprodukcijom slobodnih radikala. Cilj istraživanja  je bio da se ispita da li subakutna ishrana  dopunjena  sa 5%  mikronizovanog zeolita (MZC) ispoljava radiozaštitnu ulogu  na osnovu statusa oksidativnog stresa (OS) u mozgu i 8- hidroksiguanozina  (8-OH-dG)  u  plazmi  pacova  izloženih  pojedinačnim dozama jonizujućeg zračenja od 2 i 10 Gray  (Gy).  Metode.  Wistar  pacovi  su  bili  na  četvoronedeljnoj  normalnoj ishrani ili ishrani obogaćenoj sa 5% MZC, posle  čega su bili izloženi pojedinačnom jonizujućem zračenju od  2  Gy,  odnosno  10  Gy.  Grupe  pacova  bile  su:  a)  gru pa  pacova na normalnoj ishrani (kontrolna grupa i grupe 2Gy i  10Gy); b) grupa pacova na ishrani obogaćenoj sa 5%  MZC  (kontrolna  grupa  – MZC  i  grupe  MZC+2Gy  i   MZC+10Gy).  Meren  je  malondialdehid  (MDA),  glutation  (GSH)  i  aktivnost  ukupne  (tSOD)  i  mangan  superoksid  dizmutaze  (MnSOD)  u  osetljivim  strukturama  mozga  (cerebelum, hipokampus i cerebralni korteks), a 8-OH-dG u  plazmi.  Rezultati. Biomarker  MDA  je  bio  niži  u  MZC+2Gy i MZC+10Gy grupama, u odnosu na grupe 2Gy  i  10Gy.  Aktivnost  ukupne SOD  je  bila  viša  u  grupi  MZC+10Gy, u odnosu na grupu 10Gy. Najviši nivo GSH  bio je u grupi 10Gy. U pređenju sa kontrolnom grupom, 8- OH-dG je bio izuzetno viši u grupama ozračenim sa 10 Gy,  bez obzira na dijetetski režim i niži u grupama MZC+2Gy i  2Gy.  Zaključak. Pacovi  koji  su  bili  na  režimu  ishrane  obogaćene  sa  5%  MZC  bili  su  delimično  zaštićeni  od  zračenja, shodno redukovanoj moždanoj aktivnosti SOD pri  2  Gy i sniženom nivou MDA pri izlaganju zračenju od 2 i  10 Gy.",
publisher = "Belgrade: Military Medical Academy, INI",
journal = "Vojnosanitetski pregled",
title = "Moderate radioprotective role of zeolite in rats, Umerena radioprotektivna uloga zeolita kod pacova",
volume = "78",
number = "7",
pages = "760-768",
doi = "10.2298/VSP190702136P"
}

Pavlović, M., Đukić, M., Vojvodić, D., Ninković, M., Stevanović, I., Đurić, A.,& Stanojević, B.. (2021). Moderate radioprotective role of zeolite in rats. in Vojnosanitetski pregled
Belgrade: Military Medical Academy, INI., 78(7), 760-768.
https://doi.org/10.2298/VSP190702136P

Pavlović M, Đukić M, Vojvodić D, Ninković M, Stevanović I, Đurić A, Stanojević B. Moderate radioprotective role of zeolite in rats. in Vojnosanitetski pregled. 2021;78(7):760-768.
doi:10.2298/VSP190702136P .

Pavlović, Miloš, Đukić, Mirjana, Vojvodić, Danilo, Ninković, Milica, Stevanović, Ivana, Đurić, Ana, Stanojević, Boban, "Moderate radioprotective role of zeolite in rats" in Vojnosanitetski pregled, 78, no. 7 (2021):760-768,
https://doi.org/10.2298/VSP190702136P . .

TY  - JOUR
AU  - Dejanović, Bratislav
AU  - Vuković-Dejanović, Vesna
AU  - Ninković, Milica
AU  - Lavrnja, Irena
AU  - Stojanović, Ivana
AU  - Pavlović, Miloš
AU  - Begović, Vesna
AU  - Mirković, Duško
AU  - Stevanović, Ivana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3222
AB  - This study was aimed to study the potentially beneficial effects of agmatine on oxidative/nitrosative stress development in the brain of Wistar rats during subacute chlorpromazine treatment. The animals were divided into control (0.9% saline), chlorpromazine (38.7 mg/kg b.w.), chlorpromazine+agmatine (agmatine 75 mg/kg b.w. immediately after chlorpromazine, 38.7 mg/ kg b.w. i.p.) and agmatine (75 mg/kg b.w.) groups. All the tested substances were administered intraperitoneally for 15 consecutive days and the rats were sacrificed by decapitation on day 15. Subacute administration of chlorpromazine resulted in increased lipid peroxidation, nitric oxide concentration and superoxide anion production, while completely damaging the antioxidant defence system in the cerebral cortex, striatum, and hippocampus. However, the combined treatment with chlorpromazine and agmatine significantly attenuated the oxidative/nitrosative stress indices and restored the antioxidant capacity to the control values in all of the examined brain regions. Western blot analysis supported biochemical findings in all groups, but the most notable changes were found in the hippocampus. Our results suggest potentially beneficial effects of agmatine, which may be useful in the modified antioxidant approach in chlorpromazine-therapy.
PB  - Veterinarni A Farmaceuticka Univerzita Brno, Brno
T2  - Acta Veterinaria Brno
T1  - Effects of agmatine on chlorpromazine-induced neuronal injury in rat
VL  - 87
IS  - 2
SP  - 145
EP  - 153
DO  - 10.2754/avb201887020145
ER  - 

@article{
author = "Dejanović, Bratislav and Vuković-Dejanović, Vesna and Ninković, Milica and Lavrnja, Irena and Stojanović, Ivana and Pavlović, Miloš and Begović, Vesna and Mirković, Duško and Stevanović, Ivana",
year = "2018",
abstract = "This study was aimed to study the potentially beneficial effects of agmatine on oxidative/nitrosative stress development in the brain of Wistar rats during subacute chlorpromazine treatment. The animals were divided into control (0.9% saline), chlorpromazine (38.7 mg/kg b.w.), chlorpromazine+agmatine (agmatine 75 mg/kg b.w. immediately after chlorpromazine, 38.7 mg/ kg b.w. i.p.) and agmatine (75 mg/kg b.w.) groups. All the tested substances were administered intraperitoneally for 15 consecutive days and the rats were sacrificed by decapitation on day 15. Subacute administration of chlorpromazine resulted in increased lipid peroxidation, nitric oxide concentration and superoxide anion production, while completely damaging the antioxidant defence system in the cerebral cortex, striatum, and hippocampus. However, the combined treatment with chlorpromazine and agmatine significantly attenuated the oxidative/nitrosative stress indices and restored the antioxidant capacity to the control values in all of the examined brain regions. Western blot analysis supported biochemical findings in all groups, but the most notable changes were found in the hippocampus. Our results suggest potentially beneficial effects of agmatine, which may be useful in the modified antioxidant approach in chlorpromazine-therapy.",
publisher = "Veterinarni A Farmaceuticka Univerzita Brno, Brno",
journal = "Acta Veterinaria Brno",
title = "Effects of agmatine on chlorpromazine-induced neuronal injury in rat",
volume = "87",
number = "2",
pages = "145-153",
doi = "10.2754/avb201887020145"
}

Dejanović, B., Vuković-Dejanović, V., Ninković, M., Lavrnja, I., Stojanović, I., Pavlović, M., Begović, V., Mirković, D.,& Stevanović, I.. (2018). Effects of agmatine on chlorpromazine-induced neuronal injury in rat. in Acta Veterinaria Brno
Veterinarni A Farmaceuticka Univerzita Brno, Brno., 87(2), 145-153.
https://doi.org/10.2754/avb201887020145

Dejanović B, Vuković-Dejanović V, Ninković M, Lavrnja I, Stojanović I, Pavlović M, Begović V, Mirković D, Stevanović I. Effects of agmatine on chlorpromazine-induced neuronal injury in rat. in Acta Veterinaria Brno. 2018;87(2):145-153.
doi:10.2754/avb201887020145 .

Dejanović, Bratislav, Vuković-Dejanović, Vesna, Ninković, Milica, Lavrnja, Irena, Stojanović, Ivana, Pavlović, Miloš, Begović, Vesna, Mirković, Duško, Stevanović, Ivana, "Effects of agmatine on chlorpromazine-induced neuronal injury in rat" in Acta Veterinaria Brno, 87, no. 2 (2018):145-153,
https://doi.org/10.2754/avb201887020145 . .

TY  - JOUR
AU  - Begić, Aida
AU  - Đurić, Ana
AU  - Ninković, Milica
AU  - Stevanović, Ivana
AU  - Đurđević, Dragan
AU  - Pavlović, Miloš
AU  - Jelić, Katarina
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Dejanović, Bratislav
AU  - Stanojević, Ivan
AU  - Vojvodić, Danilo
AU  - Milosavljević, Petar
AU  - Đukić, Mirjana
AU  - Saso, Luciano
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2963
AB  - Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium
VL  - 32
IS  - 1
SP  - 478
EP  - 489
DO  - 10.1080/14756366.2016.1261132
ER  - 

@article{
author = "Begić, Aida and Đurić, Ana and Ninković, Milica and Stevanović, Ivana and Đurđević, Dragan and Pavlović, Miloš and Jelić, Katarina and Pantelić, Ana and Zebić, Goran and Dejanović, Bratislav and Stanojević, Ivan and Vojvodić, Danilo and Milosavljević, Petar and Đukić, Mirjana and Saso, Luciano",
year = "2017",
abstract = "Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O-2(center dot-)) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium",
volume = "32",
number = "1",
pages = "478-489",
doi = "10.1080/14756366.2016.1261132"
}

Begić, A., Đurić, A., Ninković, M., Stevanović, I., Đurđević, D., Pavlović, M., Jelić, K., Pantelić, A., Zebić, G., Dejanović, B., Stanojević, I., Vojvodić, D., Milosavljević, P., Đukić, M.,& Saso, L.. (2017). Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 32(1), 478-489.
https://doi.org/10.1080/14756366.2016.1261132

Begić A, Đurić A, Ninković M, Stevanović I, Đurđević D, Pavlović M, Jelić K, Pantelić A, Zebić G, Dejanović B, Stanojević I, Vojvodić D, Milosavljević P, Đukić M, Saso L. Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):478-489.
doi:10.1080/14756366.2016.1261132 .

Begić, Aida, Đurić, Ana, Ninković, Milica, Stevanović, Ivana, Đurđević, Dragan, Pavlović, Miloš, Jelić, Katarina, Pantelić, Ana, Zebić, Goran, Dejanović, Bratislav, Stanojević, Ivan, Vojvodić, Danilo, Milosavljević, Petar, Đukić, Mirjana, Saso, Luciano, "Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):478-489,
https://doi.org/10.1080/14756366.2016.1261132 . .

TY  - JOUR
AU  - Đurić, Ana
AU  - Begić, Aida
AU  - Gobeljić, Borko
AU  - Stanojević, Ivan
AU  - Ninković, Milica
AU  - Vojvodić, Danilo
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Prokić, Vera
AU  - Dejanović, Bratislav
AU  - Stojanović, Ivana
AU  - Pavlica, Marina
AU  - Đukić, Dušan
AU  - Saso, Luciano
AU  - Đurđević, Dragan
AU  - Pavlović, Miloš
AU  - Topić, Aleksandra
AU  - Vujanović, Dragana
AU  - Stevnović, Ivana
AU  - Đukić, Mirjana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2364
AB  - The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium
VL  - 86
SP  - 25
EP  - 33
DO  - 10.1016/j.fct.2015.09.004
ER  - 

@article{
author = "Đurić, Ana and Begić, Aida and Gobeljić, Borko and Stanojević, Ivan and Ninković, Milica and Vojvodić, Danilo and Pantelić, Ana and Zebić, Goran and Prokić, Vera and Dejanović, Bratislav and Stojanović, Ivana and Pavlica, Marina and Đukić, Dušan and Saso, Luciano and Đurđević, Dragan and Pavlović, Miloš and Topić, Aleksandra and Vujanović, Dragana and Stevnović, Ivana and Đukić, Mirjana",
year = "2015",
abstract = "The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium",
volume = "86",
pages = "25-33",
doi = "10.1016/j.fct.2015.09.004"
}

Đurić, A., Begić, A., Gobeljić, B., Stanojević, I., Ninković, M., Vojvodić, D., Pantelić, A., Zebić, G., Prokić, V., Dejanović, B., Stojanović, I., Pavlica, M., Đukić, D., Saso, L., Đurđević, D., Pavlović, M., Topić, A., Vujanović, D., Stevnović, I.,& Đukić, M.. (2015). Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 86, 25-33.
https://doi.org/10.1016/j.fct.2015.09.004

Đurić A, Begić A, Gobeljić B, Stanojević I, Ninković M, Vojvodić D, Pantelić A, Zebić G, Prokić V, Dejanović B, Stojanović I, Pavlica M, Đukić D, Saso L, Đurđević D, Pavlović M, Topić A, Vujanović D, Stevnović I, Đukić M. Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology. 2015;86:25-33.
doi:10.1016/j.fct.2015.09.004 .

Đurić, Ana, Begić, Aida, Gobeljić, Borko, Stanojević, Ivan, Ninković, Milica, Vojvodić, Danilo, Pantelić, Ana, Zebić, Goran, Prokić, Vera, Dejanović, Bratislav, Stojanović, Ivana, Pavlica, Marina, Đukić, Dušan, Saso, Luciano, Đurđević, Dragan, Pavlović, Miloš, Topić, Aleksandra, Vujanović, Dragana, Stevnović, Ivana, Đukić, Mirjana, "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium" in Food and Chemical Toxicology, 86 (2015):25-33,
https://doi.org/10.1016/j.fct.2015.09.004 . .

TY  - JOUR
AU  - Tasić-Kostov, Marija
AU  - Savić, Snežana
AU  - Lukić, Milica
AU  - Tamburić, Slobodanka
AU  - Pavlović, Miloš
AU  - Vuleta, Gordana
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1393
AB  - Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles - gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated. Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks. Results/conclusion LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals.
PB  - Wiley Periodicals, Inc, Malden
T2  - Journal of Cosmetic Dermatology
T1  - Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
VL  - 9
IS  - 1
SP  - 3
EP  - 10
DO  - 10.1111/j.1473-2165.2010.00474.x
ER  - 

@article{
author = "Tasić-Kostov, Marija and Savić, Snežana and Lukić, Milica and Tamburić, Slobodanka and Pavlović, Miloš and Vuleta, Gordana",
year = "2010",
abstract = "Background/aims Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles - gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated. Methods Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks. Results/conclusion LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals.",
publisher = "Wiley Periodicals, Inc, Malden",
journal = "Journal of Cosmetic Dermatology",
title = "Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid",
volume = "9",
number = "1",
pages = "3-10",
doi = "10.1111/j.1473-2165.2010.00474.x"
}

Tasić-Kostov, M., Savić, S., Lukić, M., Tamburić, S., Pavlović, M.,& Vuleta, G.. (2010). Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid. in Journal of Cosmetic Dermatology
Wiley Periodicals, Inc, Malden., 9(1), 3-10.
https://doi.org/10.1111/j.1473-2165.2010.00474.x

Tasić-Kostov M, Savić S, Lukić M, Tamburić S, Pavlović M, Vuleta G. Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid. in Journal of Cosmetic Dermatology. 2010;9(1):3-10.
doi:10.1111/j.1473-2165.2010.00474.x .

Tasić-Kostov, Marija, Savić, Snežana, Lukić, Milica, Tamburić, Slobodanka, Pavlović, Miloš, Vuleta, Gordana, "Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid" in Journal of Cosmetic Dermatology, 9, no. 1 (2010):3-10,
https://doi.org/10.1111/j.1473-2165.2010.00474.x . .