TY  - JOUR
AU  - Đurić, Ana
AU  - Begić, Aida
AU  - Gobeljić, Borko
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Stevanović, Ivana
AU  - Đurđević, Dragan
AU  - Ninković, Milica
AU  - Prokić, Vera
AU  - Stanojević, Ivan
AU  - Vojvodić, Danilo
AU  - Đukić, Mirjana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2969
AB  - The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatments (21 and/or 42 days): C-21/C-42 groups (controls); OL21 and OL22-42 groups (0.5 mL olive oil intake); A(1-21) groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day intake); and A(21)+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol). The measured parameters in testes included metals: zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg) and selenium (Se); as well as oxidative stress (OS) parameters: superoxide anion radical (O-2(center dot-)), glutathione reduced (GSH) and oxidized (GSSG), malondialdehyde (MDA), hydrogen peroxide (H2O2) decomposition and activities of total superoxide dismutase (tSOD), glutathione-Stransferase (GST) and glutathione reductase (GR). Metal status was changed in all experimental groups (Fe rose, Zn fell, while Cu increased in A(21)+DSF24-32 groups). Development of OS was demonstrated in A(1-21) groups, but not in DSF1-21 groups. In A(21)+DSF22-42 groups, OS was partially reduced compared to A groups (A(1-21)>MDA>C; A(1-21) lt GSH lt C). High metal-binding affinity of DSF/DDTC changes red-ox homeostasis in rat testes.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes
VL  - 105
SP  - 44
EP  - 51
DO  - 10.1016/j.fct.2017.03.041
ER  - 

@article{
author = "Đurić, Ana and Begić, Aida and Gobeljić, Borko and Pantelić, Ana and Zebić, Goran and Stevanović, Ivana and Đurđević, Dragan and Ninković, Milica and Prokić, Vera and Stanojević, Ivan and Vojvodić, Danilo and Đukić, Mirjana",
year = "2017",
abstract = "The aim of the study was to investigate if alcohol and disulfiram (DSF) individually and in combination affect bioelements' and red-ox homeostasis in testes of the exposed rats. The animals were divided into groups according to the duration of treatments (21 and/or 42 days): C-21/C-42 groups (controls); OL21 and OL22-42 groups (0.5 mL olive oil intake); A(1-21) groups (3 mL 20% ethanol intake); DSF1-21 groups (178.5 mg DSF/kg/day intake); and A(21)+DSF22-42 groups (the DSF ingestion followed previous 21 days' treatment with alcohol). The measured parameters in testes included metals: zinc (Zn), copper (Cu), iron (Fe), magnesium (Mg) and selenium (Se); as well as oxidative stress (OS) parameters: superoxide anion radical (O-2(center dot-)), glutathione reduced (GSH) and oxidized (GSSG), malondialdehyde (MDA), hydrogen peroxide (H2O2) decomposition and activities of total superoxide dismutase (tSOD), glutathione-Stransferase (GST) and glutathione reductase (GR). Metal status was changed in all experimental groups (Fe rose, Zn fell, while Cu increased in A(21)+DSF24-32 groups). Development of OS was demonstrated in A(1-21) groups, but not in DSF1-21 groups. In A(21)+DSF22-42 groups, OS was partially reduced compared to A groups (A(1-21)>MDA>C; A(1-21) lt GSH lt C). High metal-binding affinity of DSF/DDTC changes red-ox homeostasis in rat testes.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes",
volume = "105",
pages = "44-51",
doi = "10.1016/j.fct.2017.03.041"
}

Đurić, A., Begić, A., Gobeljić, B., Pantelić, A., Zebić, G., Stevanović, I., Đurđević, D., Ninković, M., Prokić, V., Stanojević, I., Vojvodić, D.,& Đukić, M.. (2017). Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 105, 44-51.
https://doi.org/10.1016/j.fct.2017.03.041

Đurić A, Begić A, Gobeljić B, Pantelić A, Zebić G, Stevanović I, Đurđević D, Ninković M, Prokić V, Stanojević I, Vojvodić D, Đukić M. Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes. in Food and Chemical Toxicology. 2017;105:44-51.
doi:10.1016/j.fct.2017.03.041 .

Đurić, Ana, Begić, Aida, Gobeljić, Borko, Pantelić, Ana, Zebić, Goran, Stevanović, Ivana, Đurđević, Dragan, Ninković, Milica, Prokić, Vera, Stanojević, Ivan, Vojvodić, Danilo, Đukić, Mirjana, "Subacute alcohol and/or disulfiram intake affects bioelements and redox status in rat testes" in Food and Chemical Toxicology, 105 (2017):44-51,
https://doi.org/10.1016/j.fct.2017.03.041 . .

TY  - JOUR
AU  - Đurić, Ana
AU  - Begić, Aida
AU  - Gobeljić, Borko
AU  - Stanojević, Ivan
AU  - Ninković, Milica
AU  - Vojvodić, Danilo
AU  - Pantelić, Ana
AU  - Zebić, Goran
AU  - Prokić, Vera
AU  - Dejanović, Bratislav
AU  - Stojanović, Ivana
AU  - Pavlica, Marina
AU  - Đukić, Dušan
AU  - Saso, Luciano
AU  - Đurđević, Dragan
AU  - Pavlović, Miloš
AU  - Topić, Aleksandra
AU  - Vujanović, Dragana
AU  - Stevnović, Ivana
AU  - Đukić, Mirjana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2364
AB  - The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium
VL  - 86
SP  - 25
EP  - 33
DO  - 10.1016/j.fct.2015.09.004
ER  - 

@article{
author = "Đurić, Ana and Begić, Aida and Gobeljić, Borko and Stanojević, Ivan and Ninković, Milica and Vojvodić, Danilo and Pantelić, Ana and Zebić, Goran and Prokić, Vera and Dejanović, Bratislav and Stojanović, Ivana and Pavlica, Marina and Đukić, Dušan and Saso, Luciano and Đurđević, Dragan and Pavlović, Miloš and Topić, Aleksandra and Vujanović, Dragana and Stevnović, Ivana and Đukić, Mirjana",
year = "2015",
abstract = "The objective of our study was to examine testicular toxicity of cadmium (Cd), focusing on oxidative stress (OS), essential metals and androgenic status and morphological changes. Male Wistar rats [controls and four Cd-subgroups (n = 6) organized according to the exposure (1, 3, 10 and 21 days)] were intraperitoneally (i.p.) treated with 1 mg CdCl2/kg/day. Testicular Cd deposition was noticed from the 1st day. After 10 and 21 days, copper (Cu) and iron (Fe) increased by 60-109% and 43-67%, respectively, while zinc (Zn) decreased by 24-33%. During 121 days of the exposure, decrease in testicular total superoxide dismutase (SOD) and total glutathione-s-transferase (GST) activities occurred gradually by 30-78% and 15-84%, respectively, while superoxide anion radical (O-2(center dot-)) increased gradually by 114-271%. After 10-21 days, decrease in testicular catalase (CAT) activity appeared by 13-31%. After 21 days, malondialdehyde (MDA) decreased by 44% and the ratio of oxidized glutathione/reduced glutathione (GSSG/GSH) increased by 130% in testes of the rats exposed to Cd. Additionally, decreased testicular testosterone level and the relative testes mass, along with induced microscopic and macroscopic changes were occured, what can be explained as the consequence of instantly developed OS, impaired essential metals status and Cd testicular deposition.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium",
volume = "86",
pages = "25-33",
doi = "10.1016/j.fct.2015.09.004"
}

Đurić, A., Begić, A., Gobeljić, B., Stanojević, I., Ninković, M., Vojvodić, D., Pantelić, A., Zebić, G., Prokić, V., Dejanović, B., Stojanović, I., Pavlica, M., Đukić, D., Saso, L., Đurđević, D., Pavlović, M., Topić, A., Vujanović, D., Stevnović, I.,& Đukić, M.. (2015). Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 86, 25-33.
https://doi.org/10.1016/j.fct.2015.09.004

Đurić A, Begić A, Gobeljić B, Stanojević I, Ninković M, Vojvodić D, Pantelić A, Zebić G, Prokić V, Dejanović B, Stojanović I, Pavlica M, Đukić D, Saso L, Đurđević D, Pavlović M, Topić A, Vujanović D, Stevnović I, Đukić M. Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium. in Food and Chemical Toxicology. 2015;86:25-33.
doi:10.1016/j.fct.2015.09.004 .

Đurić, Ana, Begić, Aida, Gobeljić, Borko, Stanojević, Ivan, Ninković, Milica, Vojvodić, Danilo, Pantelić, Ana, Zebić, Goran, Prokić, Vera, Dejanović, Bratislav, Stojanović, Ivana, Pavlica, Marina, Đukić, Dušan, Saso, Luciano, Đurđević, Dragan, Pavlović, Miloš, Topić, Aleksandra, Vujanović, Dragana, Stevnović, Ivana, Đukić, Mirjana, "Oxidative stress, bioelements and androgen status in testes of rats subacutely exposed to cadmium" in Food and Chemical Toxicology, 86 (2015):25-33,
https://doi.org/10.1016/j.fct.2015.09.004 . .

TY  - JOUR
AU  - Kotur-Stevuljević, Jelena
AU  - Savić, V.
AU  - Prokić, Vera
AU  - Stojanov, Marina
AU  - Černak, Ibolja
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/660
AB  - Lung trauma has been considered to be one of the vital injuries induced by explosion-generated blast overpressure. Conflicting evidence exists as to whether nitric oxide plays a crucial role in acute lung injury induced by blast. Data presented in this study demonstrate that local exposure of midthoracic region to moderate-level blast overpressure significantly enhanced lipid peroxidation product malondialdehyde and superoxide anion generation in rabbit's lungs 30 minutes after exposure, whereas the activities of antioxidant enzymes (superoxide dismutase, glutathione peroxidase) activity showed parallel increase. NG-nitro-L-arginine methyl ester, a non-specific inhibitor of nitric oxide synthase (NOS), had no effects on the measured parameters suggesting that oxidative stress induced by blast exposure might be independent from NOS.
AB  - Smatra se da je povreda pluća jedna od najvažnijih povreda do kojih dolazi delovanjem blast talasa generisanog na mestu eksplozije. Do danas ne postoji definitivan stav da li azot-monoksid ima bitnu ulogu u akutnoj blast povredi pluća. Rezultati ove studije pokazuju da lokalno delovanje blast nadpritiska srednje jačine na središnji deo toraksa dovodi do povećanog stvaranja malondialdehida, produkta lipidne peroksidacije kao i povećanog generisanja superoksidnog anjona, 30 minuta posle traume. Istovremeno, dolazi do smanjenja aktivnosti antioksidativnih enzima (superoksid-dizmutaze i glutation-peroksidaze) u plućnom tkivu kunića. NG-nitro-L-arginin-metil estar (L-NAME), nespecifični inhibitor enzima azot-monoksid sintaze (NOS) nije imao efekta na određivane parametere, što ukazuje daje oskidativni stres indukovan blast povredom verovatno nezavisan od aktivnosti enzima NOS.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production
T1  - Oksidativni stres u akutnoj blast povredi pluća je nezavisan od enzimske sinteze azot-monoksida
VL  - 55
IS  - 5-6
SP  - 385
EP  - 394
DO  - 10.2298/AVB0506385K
ER  - 

@article{
author = "Kotur-Stevuljević, Jelena and Savić, V. and Prokić, Vera and Stojanov, Marina and Černak, Ibolja",
year = "2005",
abstract = "Lung trauma has been considered to be one of the vital injuries induced by explosion-generated blast overpressure. Conflicting evidence exists as to whether nitric oxide plays a crucial role in acute lung injury induced by blast. Data presented in this study demonstrate that local exposure of midthoracic region to moderate-level blast overpressure significantly enhanced lipid peroxidation product malondialdehyde and superoxide anion generation in rabbit's lungs 30 minutes after exposure, whereas the activities of antioxidant enzymes (superoxide dismutase, glutathione peroxidase) activity showed parallel increase. NG-nitro-L-arginine methyl ester, a non-specific inhibitor of nitric oxide synthase (NOS), had no effects on the measured parameters suggesting that oxidative stress induced by blast exposure might be independent from NOS., Smatra se da je povreda pluća jedna od najvažnijih povreda do kojih dolazi delovanjem blast talasa generisanog na mestu eksplozije. Do danas ne postoji definitivan stav da li azot-monoksid ima bitnu ulogu u akutnoj blast povredi pluća. Rezultati ove studije pokazuju da lokalno delovanje blast nadpritiska srednje jačine na središnji deo toraksa dovodi do povećanog stvaranja malondialdehida, produkta lipidne peroksidacije kao i povećanog generisanja superoksidnog anjona, 30 minuta posle traume. Istovremeno, dolazi do smanjenja aktivnosti antioksidativnih enzima (superoksid-dizmutaze i glutation-peroksidaze) u plućnom tkivu kunića. NG-nitro-L-arginin-metil estar (L-NAME), nespecifični inhibitor enzima azot-monoksid sintaze (NOS) nije imao efekta na određivane parametere, što ukazuje daje oskidativni stres indukovan blast povredom verovatno nezavisan od aktivnosti enzima NOS.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production, Oksidativni stres u akutnoj blast povredi pluća je nezavisan od enzimske sinteze azot-monoksida",
volume = "55",
number = "5-6",
pages = "385-394",
doi = "10.2298/AVB0506385K"
}

Kotur-Stevuljević, J., Savić, V., Prokić, V., Stojanov, M.,& Černak, I.. (2005). Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 55(5-6), 385-394.
https://doi.org/10.2298/AVB0506385K

Kotur-Stevuljević J, Savić V, Prokić V, Stojanov M, Černak I. Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production. in Acta veterinaria. 2005;55(5-6):385-394.
doi:10.2298/AVB0506385K .

Kotur-Stevuljević, Jelena, Savić, V., Prokić, Vera, Stojanov, Marina, Černak, Ibolja, "Oxidative stress in blast-induced acute lung injury is independent of enzymatic nitric oxide production" in Acta veterinaria, 55, no. 5-6 (2005):385-394,
https://doi.org/10.2298/AVB0506385K . .

TY  - JOUR
AU  - Prokić, Vera
AU  - Kotur, Jelena
AU  - Černak, Ibolja
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/271
AB  - The blast wave overpressure generated by explosive material detonations causes pulmonary pathological alterations which affect the general and cerebral response of the organism to the blast injury. The aim of this study was to evaluate the development of oxidative stress (lipid peroxidation and superoxide anion) and the action of the antioxidant protection (superoxide dismutase) in bronchial and alveolar regions of the lungs. Rabbits were divided into two groups - blast and control. The blast group was exposed to blast wave overpressure focused on to the thoracic region, that was generated in laboratory conditions using an air-driven shock tube. The pulmonary injury was moderate and defined as confluent ecchymoses involving 30 - 60 % of lung tissue.The animals were sacrificed by decapitation after the early posttraumatic period of 30 minutes following blast injury. On the basis of obtained results it was concluded that there were statistically significant differences between blast and control group considering the increased oxidative stress in injured animals and respectively, the impairment of the antioxidative protection. It is suggested that the increased generation of reactive oxygen species in lungs could be a marker of serious pulmonary injury.
AB  - Talas vazdušnog nadpritiska (² blast ²) koji nastaje kao posledica detonacije eksplozivnih materija izaziva patološke promene na plućima koje utiču na opšti i cerebralni odgovor organizma na ²blast² povredu. Cilj ovog istraživanja je bio da proceni razvoj oksidativnog stresa (lipidna peroksidacija i superoksidni anjon) i antioksidativnog sistema zaštite (superoksid dismutaza) u bronhijalnom i alveolarnom regionu pluća nakon ²blast² povrede. Životinje su bile podeljene u dve grupe - BLAST i KONTROLA. Blast grupa je bila izložena talasu vazdušnog nadpritiska generisanog u laboratorijskim uslovima. Umerena povreda pluća je izražavana kao postojanje konfluentne ekhimoze u obimu od 30-60 % od ukupnog plućnog tkiva. Životinje su žrtvovane dekapitacijom u ranom posttraumatskom periodu od 30 minuta nakon nanošenja povrede. Na osnovu dobijenih rezultata zaključeno je da postoje statistički značajne razlike između blast i kontrolne grupe u smislu povećanja vrednosti parametara oksidativnog stresa kod povređenih zečeva kao i slabljenje antioksidativne zaštite. Kao rezultat ovog rada nastala je pretpostavka da povećana proizvodnja reaktivnih oksidativnih radikala u plućima može biti znak teške povrede pluća.
PB  - Unija bioloških naučnih društava Jugoslavije, Beograd
T2  - Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
T1  - Parameters of oxidative stress in rabbits with pulmonary blast injury
T1  - Parametri oksidativnog stresa u blast povredi pluća kod zeca
VL  - 36
IS  - 1
SP  - 33
EP  - 42
UR  - https://hdl.handle.net/21.15107/rcub_farfar_271
ER  - 

@article{
author = "Prokić, Vera and Kotur, Jelena and Černak, Ibolja",
year = "2000",
abstract = "The blast wave overpressure generated by explosive material detonations causes pulmonary pathological alterations which affect the general and cerebral response of the organism to the blast injury. The aim of this study was to evaluate the development of oxidative stress (lipid peroxidation and superoxide anion) and the action of the antioxidant protection (superoxide dismutase) in bronchial and alveolar regions of the lungs. Rabbits were divided into two groups - blast and control. The blast group was exposed to blast wave overpressure focused on to the thoracic region, that was generated in laboratory conditions using an air-driven shock tube. The pulmonary injury was moderate and defined as confluent ecchymoses involving 30 - 60 % of lung tissue.The animals were sacrificed by decapitation after the early posttraumatic period of 30 minutes following blast injury. On the basis of obtained results it was concluded that there were statistically significant differences between blast and control group considering the increased oxidative stress in injured animals and respectively, the impairment of the antioxidative protection. It is suggested that the increased generation of reactive oxygen species in lungs could be a marker of serious pulmonary injury., Talas vazdušnog nadpritiska (² blast ²) koji nastaje kao posledica detonacije eksplozivnih materija izaziva patološke promene na plućima koje utiču na opšti i cerebralni odgovor organizma na ²blast² povredu. Cilj ovog istraživanja je bio da proceni razvoj oksidativnog stresa (lipidna peroksidacija i superoksidni anjon) i antioksidativnog sistema zaštite (superoksid dismutaza) u bronhijalnom i alveolarnom regionu pluća nakon ²blast² povrede. Životinje su bile podeljene u dve grupe - BLAST i KONTROLA. Blast grupa je bila izložena talasu vazdušnog nadpritiska generisanog u laboratorijskim uslovima. Umerena povreda pluća je izražavana kao postojanje konfluentne ekhimoze u obimu od 30-60 % od ukupnog plućnog tkiva. Životinje su žrtvovane dekapitacijom u ranom posttraumatskom periodu od 30 minuta nakon nanošenja povrede. Na osnovu dobijenih rezultata zaključeno je da postoje statistički značajne razlike između blast i kontrolne grupe u smislu povećanja vrednosti parametara oksidativnog stresa kod povređenih zečeva kao i slabljenje antioksidativne zaštite. Kao rezultat ovog rada nastala je pretpostavka da povećana proizvodnja reaktivnih oksidativnih radikala u plućima može biti znak teške povrede pluća.",
publisher = "Unija bioloških naučnih društava Jugoslavije, Beograd",
journal = "Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta",
title = "Parameters of oxidative stress in rabbits with pulmonary blast injury, Parametri oksidativnog stresa u blast povredi pluća kod zeca",
volume = "36",
number = "1",
pages = "33-42",
url = "https://hdl.handle.net/21.15107/rcub_farfar_271"
}

Prokić, V., Kotur, J.,& Černak, I.. (2000). Parameters of oxidative stress in rabbits with pulmonary blast injury. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta
Unija bioloških naučnih društava Jugoslavije, Beograd., 36(1), 33-42.
https://hdl.handle.net/21.15107/rcub_farfar_271

Prokić V, Kotur J, Černak I. Parameters of oxidative stress in rabbits with pulmonary blast injury. in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta. 2000;36(1):33-42.
https://hdl.handle.net/21.15107/rcub_farfar_271 .

Prokić, Vera, Kotur, Jelena, Černak, Ibolja, "Parameters of oxidative stress in rabbits with pulmonary blast injury" in Acta biologica iugoslavica - serija C: Physiologica et pharmacologica acta, 36, no. 1 (2000):33-42,
https://hdl.handle.net/21.15107/rcub_farfar_271 .