Milojković-Opsenica, Dušanka

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orcid::0000-0001-6274-4222
  • Milojković-Opsenica, Dušanka (10)
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Author's Bibliography

Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites

Odović, Jadranka; Aleksić, Mirjana; Stojimirović, Biljana; Milojković-Opsenica, Dušanka; Tešić, Živoslav

(Srpsko hemijsko društvo, Beograd, 2009)

TY  - JOUR
AU  - Odović, Jadranka
AU  - Aleksić, Mirjana
AU  - Stojimirović, Biljana
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1294
AB  - The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography.
AB  - Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites
T1  - Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita
VL  - 74
IS  - 6
SP  - 677
EP  - 688
DO  - 10.2298/JSC0906677O
ER  - 
@article{
author = "Odović, Jadranka and Aleksić, Mirjana and Stojimirović, Biljana and Milojković-Opsenica, Dušanka and Tešić, Živoslav",
year = "2009",
abstract = "The separation and chromatographic behaviour of five ACE (angiotensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship between the RM values and the composition of employed mobile phase was obtained. The hydrophobicity parameters 0M R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipophilicity of the studied ACE inhibitors and their metabolites, previously estimated by reversed-phase chromatography., Hromatografsko razdvajanje I ponašanje pet ASE inhibitora (inhibitora angio-tenzin-konvertujućeg enzima) I njihova četiri aktivna metabolita ispitivano je metodom normalno-fazne tankoslojne hromatografije na silika-gelu primenom nekoliko jedno- I dvo-komponentnih nevodenih sistema rastvarača. Dobijena je linearna zavisnost između RM-vrednosti I koncentracije etanola u mobilnoj fazi. Na osnovu odgovarajućih regresionih podataka, po analogiji sa reverzno-faznom hromatografijom, izračunati su parametri lipofilnosti 0M R I C0. Hromatografski dobijeni parametri hidrofobnosti korelisani su sa izračunatim log P vrednostima. Takođe, 0M R -vrednosti dobijene u ovom radu korelisane su sa 0M R -vrednostima dobijenim metodom reverzno-fazne tankoslojne hromatografije.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites, Normalno-fazna tankoslojna hromatografija nekih ACE inhibitora i njihovih metabolita",
volume = "74",
number = "6",
pages = "677-688",
doi = "10.2298/JSC0906677O"
}
Odović, J., Aleksić, M., Stojimirović, B., Milojković-Opsenica, D.,& Tešić, Ž.. (2009). Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 74(6), 677-688.
https://doi.org/10.2298/JSC0906677O
Odović J, Aleksić M, Stojimirović B, Milojković-Opsenica D, Tešić Ž. Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites. in Journal of the Serbian Chemical Society. 2009;74(6):677-688.
doi:10.2298/JSC0906677O .
Odović, Jadranka, Aleksić, Mirjana, Stojimirović, Biljana, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites" in Journal of the Serbian Chemical Society, 74, no. 6 (2009):677-688,
https://doi.org/10.2298/JSC0906677O . .
16
16
17

TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents

Tosti, Tomislav; Rakić, Gordana; Natić, Maja; Milojković-Opsenica, Dušanka; Husinec, Suren; Savić, Vladimir; Tešić, Živoslav

(Akademiai Kiado Zrt, Budapest, 2009)

TY  - JOUR
AU  - Tosti, Tomislav
AU  - Rakić, Gordana
AU  - Natić, Maja
AU  - Milojković-Opsenica, Dušanka
AU  - Husinec, Suren
AU  - Savić, Vladimir
AU  - Tešić, Živoslav
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1199
AB  - The chromatographic behavior of three biocidal technical materials, rodenticide active ingredients brodifacoum, bromadiolone, and coumatetralyl, and impurities present in the technical material was investigated by both normal-phase (NP) and reversed-phase (RP) planar chromatography. The research was carried out using thin-layers of silica gel, alumina, cellulose, and C-18 silica. Several solvents on their own or in various combinations and proportions were used for separation. The optimum chromatographic systems for separation of the substances from each other and from their impurities were selected. Under reversed-phase chromatographic (RPC) conditions a linear correlation between R-M values and mobile phase composition was established. From results obtained, the lipophilicity R-M(o) and C-0 were determined. Possible separation mechanisms are discussed on the basis of the established retention behavior.
PB  - Akademiai Kiado Zrt, Budapest
T2  - Journal of Planar Chromatography - Modern TLC
T1  - TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents
VL  - 22
IS  - 5
SP  - 333
EP  - 343
DO  - 10.1556/JPC.22.2009.5.4
ER  - 
@article{
author = "Tosti, Tomislav and Rakić, Gordana and Natić, Maja and Milojković-Opsenica, Dušanka and Husinec, Suren and Savić, Vladimir and Tešić, Živoslav",
year = "2009",
abstract = "The chromatographic behavior of three biocidal technical materials, rodenticide active ingredients brodifacoum, bromadiolone, and coumatetralyl, and impurities present in the technical material was investigated by both normal-phase (NP) and reversed-phase (RP) planar chromatography. The research was carried out using thin-layers of silica gel, alumina, cellulose, and C-18 silica. Several solvents on their own or in various combinations and proportions were used for separation. The optimum chromatographic systems for separation of the substances from each other and from their impurities were selected. Under reversed-phase chromatographic (RPC) conditions a linear correlation between R-M values and mobile phase composition was established. From results obtained, the lipophilicity R-M(o) and C-0 were determined. Possible separation mechanisms are discussed on the basis of the established retention behavior.",
publisher = "Akademiai Kiado Zrt, Budapest",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents",
volume = "22",
number = "5",
pages = "333-343",
doi = "10.1556/JPC.22.2009.5.4"
}
Tosti, T., Rakić, G., Natić, M., Milojković-Opsenica, D., Husinec, S., Savić, V.,& Tešić, Ž.. (2009). TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents. in Journal of Planar Chromatography - Modern TLC
Akademiai Kiado Zrt, Budapest., 22(5), 333-343.
https://doi.org/10.1556/JPC.22.2009.5.4
Tosti T, Rakić G, Natić M, Milojković-Opsenica D, Husinec S, Savić V, Tešić Ž. TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents. in Journal of Planar Chromatography - Modern TLC. 2009;22(5):333-343.
doi:10.1556/JPC.22.2009.5.4 .
Tosti, Tomislav, Rakić, Gordana, Natić, Maja, Milojković-Opsenica, Dušanka, Husinec, Suren, Savić, Vladimir, Tešić, Živoslav, "TLC Retention Behavior of Brodifacoum, Bromadiolone, and Coumatetralyl and their Impurities on Different Adsorbents" in Journal of Planar Chromatography - Modern TLC, 22, no. 5 (2009):333-343,
https://doi.org/10.1556/JPC.22.2009.5.4 . .
3
3
4

Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites

Odović, Jadranka; Stojimirović, Biljana; Aleksić, Mirjana; Milojković-Opsenica, Dušanka; Tešić, Živoslav

(Srpsko hemijsko društvo, Beograd, 2006)

TY  - JOUR
AU  - Odović, Jadranka
AU  - Stojimirović, Biljana
AU  - Aleksić, Mirjana
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/877
AB  - The chromatographic behaviour of some ACE inhibitors and their active metabolites was examined under conditions of reversed-phase thin-layer chromatography on RP-18 silica using water-methanol, water-ethanol and water-acetone as binary solvent systems. The relationship between the R M values and the concentration of organic modifier in the mobile phases was linear. It was found that an increase in the content of the organicmodifier in the employed solvent systems led to a decrease of the R M values, i.e., of the retention. Also, the more hydrophobic compounds had a longer retention. Based on regression analysis of the plots, the lipophilicity parameters R M 0 and c 0 were calculated. The chromatographically obtained lipophilicity parameters were correlated with the calculated log P values.
AB  - Ispitivano je hromatografsko ponašanje nekih ACE inhibitora i njihovih aktivnih metabolita u uslovima reversno-fazne tankoslojne hromatografije na RP-18 silika-gelu primenom sledećih binarnih sistema rastvarača voda-metanol, voda-etanol i voda-aceton. Utvrđena je linearna zavisnost između RM-vrednosti i koncentracije organskog modifikatora u mobilnoj fazi. Nađeno je da povećanje sadržaja organskog modifikatora u upotrebljenom rastvaraču dovodi do opadanja RM-vrednosti, odnosno do slabljenja retencije. Jača retencija uočena je za hidrofobnije supstance. Na osnovu odgovarajućih regresionih podataka, izračunati su parametri lipofilnosti RM 0 i c0. Hromatografski utvrđeni parametri lipofilnosti korelisani su sa izračunatim log P vrednostima.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites
T1  - Reversno-fazna tankoslojna hromatografija nekih inhibitora angiotenzin-konvertujućih enzima (ACE) i njihovih aktivnih metabolita
VL  - 71
IS  - 6
SP  - 621
EP  - 628
DO  - 10.2298/JSC0606621O
ER  - 
@article{
author = "Odović, Jadranka and Stojimirović, Biljana and Aleksić, Mirjana and Milojković-Opsenica, Dušanka and Tešić, Živoslav",
year = "2006",
abstract = "The chromatographic behaviour of some ACE inhibitors and their active metabolites was examined under conditions of reversed-phase thin-layer chromatography on RP-18 silica using water-methanol, water-ethanol and water-acetone as binary solvent systems. The relationship between the R M values and the concentration of organic modifier in the mobile phases was linear. It was found that an increase in the content of the organicmodifier in the employed solvent systems led to a decrease of the R M values, i.e., of the retention. Also, the more hydrophobic compounds had a longer retention. Based on regression analysis of the plots, the lipophilicity parameters R M 0 and c 0 were calculated. The chromatographically obtained lipophilicity parameters were correlated with the calculated log P values., Ispitivano je hromatografsko ponašanje nekih ACE inhibitora i njihovih aktivnih metabolita u uslovima reversno-fazne tankoslojne hromatografije na RP-18 silika-gelu primenom sledećih binarnih sistema rastvarača voda-metanol, voda-etanol i voda-aceton. Utvrđena je linearna zavisnost između RM-vrednosti i koncentracije organskog modifikatora u mobilnoj fazi. Nađeno je da povećanje sadržaja organskog modifikatora u upotrebljenom rastvaraču dovodi do opadanja RM-vrednosti, odnosno do slabljenja retencije. Jača retencija uočena je za hidrofobnije supstance. Na osnovu odgovarajućih regresionih podataka, izračunati su parametri lipofilnosti RM 0 i c0. Hromatografski utvrđeni parametri lipofilnosti korelisani su sa izračunatim log P vrednostima.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites, Reversno-fazna tankoslojna hromatografija nekih inhibitora angiotenzin-konvertujućih enzima (ACE) i njihovih aktivnih metabolita",
volume = "71",
number = "6",
pages = "621-628",
doi = "10.2298/JSC0606621O"
}
Odović, J., Stojimirović, B., Aleksić, M., Milojković-Opsenica, D.,& Tešić, Ž.. (2006). Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 71(6), 621-628.
https://doi.org/10.2298/JSC0606621O
Odović J, Stojimirović B, Aleksić M, Milojković-Opsenica D, Tešić Ž. Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites. in Journal of the Serbian Chemical Society. 2006;71(6):621-628.
doi:10.2298/JSC0606621O .
Odović, Jadranka, Stojimirović, Biljana, Aleksić, Mirjana, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Reversed-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their active metabolites" in Journal of the Serbian Chemical Society, 71, no. 6 (2006):621-628,
https://doi.org/10.2298/JSC0606621O . .
14
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21

Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography

Odović, Jadranka; Stojimirović, Biljana; Aleksić, Mirjana; Milojković-Opsenica, Dušanka; Tešić, Živoslav

(Research Inst Medicinal Plants, Budakalasz, 2005)

TY  - JOUR
AU  - Odović, Jadranka
AU  - Stojimirović, Biljana
AU  - Aleksić, Mirjana
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/584
AB  - The behavior of five ACE inhibitors and their active degradation products in salting-out thin-layer chromatography (SO TLC) has been examined on silica gel, cellulose, and polyacrylonitrile (PAN) with aqueous ammonium sulfate solutions of different concentration as mobile phases. It was found that increasing the concentration of the salt in the mobile phase led to increased R-M values for all the substances. Linear relationships were established between salt concentration and R-M values and regression data of the plots obtained were used to determine the lipophilicity R-M(0) and C-0. Lipophilicity determined in this way was correlated with calculated log P values. For comparison of these results with chromatographic behavior in conventional RP TLC, the examined substances were subjected to thin-layer chromatography on RP-18 silica gel with methanol-water mobile phases.
PB  - Research Inst Medicinal Plants, Budakalasz
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography
VL  - 18
IS  - 102
SP  - 98
EP  - 103
DO  - 10.1556/JPC.18.2005.2.2
ER  - 
@article{
author = "Odović, Jadranka and Stojimirović, Biljana and Aleksić, Mirjana and Milojković-Opsenica, Dušanka and Tešić, Živoslav",
year = "2005",
abstract = "The behavior of five ACE inhibitors and their active degradation products in salting-out thin-layer chromatography (SO TLC) has been examined on silica gel, cellulose, and polyacrylonitrile (PAN) with aqueous ammonium sulfate solutions of different concentration as mobile phases. It was found that increasing the concentration of the salt in the mobile phase led to increased R-M values for all the substances. Linear relationships were established between salt concentration and R-M values and regression data of the plots obtained were used to determine the lipophilicity R-M(0) and C-0. Lipophilicity determined in this way was correlated with calculated log P values. For comparison of these results with chromatographic behavior in conventional RP TLC, the examined substances were subjected to thin-layer chromatography on RP-18 silica gel with methanol-water mobile phases.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography",
volume = "18",
number = "102",
pages = "98-103",
doi = "10.1556/JPC.18.2005.2.2"
}
Odović, J., Stojimirović, B., Aleksić, M., Milojković-Opsenica, D.,& Tešić, Ž.. (2005). Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography. in Journal of Planar Chromatography - Modern TLC
Research Inst Medicinal Plants, Budakalasz., 18(102), 98-103.
https://doi.org/10.1556/JPC.18.2005.2.2
Odović J, Stojimirović B, Aleksić M, Milojković-Opsenica D, Tešić Ž. Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography. in Journal of Planar Chromatography - Modern TLC. 2005;18(102):98-103.
doi:10.1556/JPC.18.2005.2.2 .
Odović, Jadranka, Stojimirović, Biljana, Aleksić, Mirjana, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Examination of the hydrophobicity of ACE inhibitors and their active metabolites by salting-out thin-layer chromatography" in Journal of Planar Chromatography - Modern TLC, 18, no. 102 (2005):98-103,
https://doi.org/10.1556/JPC.18.2005.2.2 . .
13
12
18

Salting-out thin-layer chromatography of several myorelaxants

Aleksić, Mirjana; Odović, Jadranka; Milojković-Opsenica, Dušanka; Tešić, Živoslav

(Research Inst Medicinal Plants, Budakalasz, 2003)

TY  - JOUR
AU  - Aleksić, Mirjana
AU  - Odović, Jadranka
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/415
AB  - The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hR(F) values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the R-M values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters R-M(0) and C-0. Lipophilicity determined in this way correlated with calculated log P values.
PB  - Research Inst Medicinal Plants, Budakalasz
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Salting-out thin-layer chromatography of several myorelaxants
VL  - 16
IS  - 2
SP  - 144
EP  - 146
DO  - 10.1556/JPC.16.2003.2.11
ER  - 
@article{
author = "Aleksić, Mirjana and Odović, Jadranka and Milojković-Opsenica, Dušanka and Tešić, Živoslav",
year = "2003",
abstract = "The chromatographic behavior of five myorelaxant drugs has been studied under the conditions used for salting-out thin-layer chromatography (SOTLC) on cellulose and alumina. For this purpose, aqueous ammonium sulfate solutions of different concentration were used as mobile phases. It was established that hR(F) values always decreased in parallel to increasing salt concentrations. When cellulose was used as adsorbent, a linear relationship was observed between the R-M values and the ammonium sulfate content of the mobile phase. Regression data of the plots obtained were used to determine the lipophilicity parameters R-M(0) and C-0. Lipophilicity determined in this way correlated with calculated log P values.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Salting-out thin-layer chromatography of several myorelaxants",
volume = "16",
number = "2",
pages = "144-146",
doi = "10.1556/JPC.16.2003.2.11"
}
Aleksić, M., Odović, J., Milojković-Opsenica, D.,& Tešić, Ž.. (2003). Salting-out thin-layer chromatography of several myorelaxants. in Journal of Planar Chromatography - Modern TLC
Research Inst Medicinal Plants, Budakalasz., 16(2), 144-146.
https://doi.org/10.1556/JPC.16.2003.2.11
Aleksić M, Odović J, Milojković-Opsenica D, Tešić Ž. Salting-out thin-layer chromatography of several myorelaxants. in Journal of Planar Chromatography - Modern TLC. 2003;16(2):144-146.
doi:10.1556/JPC.16.2003.2.11 .
Aleksić, Mirjana, Odović, Jadranka, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Salting-out thin-layer chromatography of several myorelaxants" in Journal of Planar Chromatography - Modern TLC, 16, no. 2 (2003):144-146,
https://doi.org/10.1556/JPC.16.2003.2.11 . .
12
9
12

Estimation of the hydrophobicity of antimycotic compounds by planar chromatography

Aleksić, Mirjana; Erić, Slavica; Agbaba, Danica; Odović, Jadranka; Milojković-Opsenica, Dušanka; Tesić, I

(Research Inst Medicinal Plants, Budakalasz, 2002)

TY  - JOUR
AU  - Aleksić, Mirjana
AU  - Erić, Slavica
AU  - Agbaba, Danica
AU  - Odović, Jadranka
AU  - Milojković-Opsenica, Dušanka
AU  - Tesić, I
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/342
AB  - The retention behavior of bifonazole, clotrimazole, fenticonazole, fluconazole, ketoconazole, miconazole, metronidazole, and itraconazole, widely used antimycotic drugs have been determined by TLC by use of the binary mobile phases acetone-n-hexane, methanol-toluene, and methyl ethyl ketone-toluene containing different amounts of organic modifier. Hydrophobicity was established from the linear relationships between the solute R-M values and the concentration of organic modifier. Calculated values of R-M(0) and C-0 were considered for application in QSAR studies of the antimycotics.
PB  - Research Inst Medicinal Plants, Budakalasz
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Estimation of the hydrophobicity of antimycotic compounds by planar chromatography
VL  - 15
IS  - 6
SP  - 414
EP  - 417
DO  - 10.1556/JPC.15.2002.6.4
ER  - 
@article{
author = "Aleksić, Mirjana and Erić, Slavica and Agbaba, Danica and Odović, Jadranka and Milojković-Opsenica, Dušanka and Tesić, I",
year = "2002",
abstract = "The retention behavior of bifonazole, clotrimazole, fenticonazole, fluconazole, ketoconazole, miconazole, metronidazole, and itraconazole, widely used antimycotic drugs have been determined by TLC by use of the binary mobile phases acetone-n-hexane, methanol-toluene, and methyl ethyl ketone-toluene containing different amounts of organic modifier. Hydrophobicity was established from the linear relationships between the solute R-M values and the concentration of organic modifier. Calculated values of R-M(0) and C-0 were considered for application in QSAR studies of the antimycotics.",
publisher = "Research Inst Medicinal Plants, Budakalasz",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Estimation of the hydrophobicity of antimycotic compounds by planar chromatography",
volume = "15",
number = "6",
pages = "414-417",
doi = "10.1556/JPC.15.2002.6.4"
}
Aleksić, M., Erić, S., Agbaba, D., Odović, J., Milojković-Opsenica, D.,& Tesić, I.. (2002). Estimation of the hydrophobicity of antimycotic compounds by planar chromatography. in Journal of Planar Chromatography - Modern TLC
Research Inst Medicinal Plants, Budakalasz., 15(6), 414-417.
https://doi.org/10.1556/JPC.15.2002.6.4
Aleksić M, Erić S, Agbaba D, Odović J, Milojković-Opsenica D, Tesić I. Estimation of the hydrophobicity of antimycotic compounds by planar chromatography. in Journal of Planar Chromatography - Modern TLC. 2002;15(6):414-417.
doi:10.1556/JPC.15.2002.6.4 .
Aleksić, Mirjana, Erić, Slavica, Agbaba, Danica, Odović, Jadranka, Milojković-Opsenica, Dušanka, Tesić, I, "Estimation of the hydrophobicity of antimycotic compounds by planar chromatography" in Journal of Planar Chromatography - Modern TLC, 15, no. 6 (2002):414-417,
https://doi.org/10.1556/JPC.15.2002.6.4 . .
17
15
22

Thin-layer chromatography of several miorelaxans

Aleksić, Mirjana; Tešić, Živoslav; Milojković-Opsenica, Dušanka; Odović, Jadranka

(Savez farmaceutskih udruženja Srbije, Beograd, 2002)

TY  - CONF
AU  - Aleksić, Mirjana
AU  - Tešić, Živoslav
AU  - Milojković-Opsenica, Dušanka
AU  - Odović, Jadranka
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/381
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Thin-layer chromatography of several miorelaxans
T1  - Tankoslojna hromatografija nekih miorelaksanasa
VL  - 52
IS  - 4
SP  - 494
EP  - 495
UR  - https://hdl.handle.net/21.15107/rcub_cherry_130
ER  - 
@conference{
author = "Aleksić, Mirjana and Tešić, Živoslav and Milojković-Opsenica, Dušanka and Odović, Jadranka",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Thin-layer chromatography of several miorelaxans, Tankoslojna hromatografija nekih miorelaksanasa",
volume = "52",
number = "4",
pages = "494-495",
url = "https://hdl.handle.net/21.15107/rcub_cherry_130"
}
Aleksić, M., Tešić, Ž., Milojković-Opsenica, D.,& Odović, J.. (2002). Thin-layer chromatography of several miorelaxans. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 494-495.
https://hdl.handle.net/21.15107/rcub_cherry_130
Aleksić M, Tešić Ž, Milojković-Opsenica D, Odović J. Thin-layer chromatography of several miorelaxans. in Arhiv za farmaciju. 2002;52(4):494-495.
https://hdl.handle.net/21.15107/rcub_cherry_130 .
Aleksić, Mirjana, Tešić, Živoslav, Milojković-Opsenica, Dušanka, Odović, Jadranka, "Thin-layer chromatography of several miorelaxans" in Arhiv za farmaciju, 52, no. 4 (2002):494-495,
https://hdl.handle.net/21.15107/rcub_cherry_130 .

Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors

Aleksić, Mirjana; Agbaba, Danica; Baošić, Rada M.; Milojković-Opsenica, Dušanka; Tešić, Živoslav

(Srpsko hemijsko društvo, Beograd, 2001)

TY  - JOUR
AU  - Aleksić, Mirjana
AU  - Agbaba, Danica
AU  - Baošić, Rada M.
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/308
AB  - A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used.
AB  - U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors
T1  - Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora
VL  - 66
IS  - 1
SP  - 39
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_farfar_308
ER  - 
@article{
author = "Aleksić, Mirjana and Agbaba, Danica and Baošić, Rada M. and Milojković-Opsenica, Dušanka and Tešić, Živoslav",
year = "2001",
abstract = "A rapid and simple method for the chromatographic separation of pharmacologically active components contained in some antihypertensive drugs has been developed employing thin-layers of silica gel and polyacrylonitrile sorbent (PANS). The active compounds of Captopril - (S)-1-(3-mercapto-2- methyl-1-oxopropyl)-L-proline, Enalapril - (S)-1-[N-[1-(ethoxycarbonyl)-3- phenylpropyl]-L-alanyl]-L-proline, Lisinopril - (S) -1-[N2-(carboxy-3- phenylpropyl)-L-lysyl]-L-proline, Quinapril - [3S-[2[R*(R*)],3R*]],-2-[2-[[1 (-ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3- iso-quinoline-carboxylic acid, Ramipril - [2S-[1[R*(R*)],2α,3αβ,6αβ]]-1-[2[[ 1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[β]- pyrole-2-carboxylic acid and Cilazapril - [1S-[1α,9α(R*)]]-9-[[1- (ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-α] [1,2]diazepine-1-carboxylic acid, were successfully separated by the presented procedures. For their chromatographic separation on silica gel sixteen and on PANS thirteen solvents were used., U radu je u uslovima hromatografije na tankim slojevima silika-gela i poliakrilonitrilnog sorbenta (PANS-a), izvršeno razdvajanje sledećih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora (ACE inhibitora): Kaptopril-a, Enalapril-a, Lizinopril-a, Kvinapril-a, Ramipril-a, Cilazapril-a. Za njihovo hromatografsko razdvajanje upotrebljeni su mnogi rastvarači. Na osnovu dobijenih rezultata diskutovani su mehanizmi odvajanja. Na taj način data je jedna veoma brza i jednostavna metoda za odvajanje pomenutih supstanci.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors, Tankoslojna hromatografija nekih antihipertenziva iz grupe angiotenzin konvertujućih enzim inhibitora",
volume = "66",
number = "1",
pages = "39-44",
url = "https://hdl.handle.net/21.15107/rcub_farfar_308"
}
Aleksić, M., Agbaba, D., Baošić, R. M., Milojković-Opsenica, D.,& Tešić, Ž.. (2001). Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 66(1), 39-44.
https://hdl.handle.net/21.15107/rcub_farfar_308
Aleksić M, Agbaba D, Baošić RM, Milojković-Opsenica D, Tešić Ž. Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors. in Journal of the Serbian Chemical Society. 2001;66(1):39-44.
https://hdl.handle.net/21.15107/rcub_farfar_308 .
Aleksić, Mirjana, Agbaba, Danica, Baošić, Rada M., Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Thin-layer chromatography of several antihypertensive drugs from the group of angiotensin converting enzyme inhibitors" in Journal of the Serbian Chemical Society, 66, no. 1 (2001):39-44,
https://hdl.handle.net/21.15107/rcub_farfar_308 .
8
10

Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents

Aleksić, Mirjana; Agbaba, Danica; Milojković-Opsenica, Dušanka; Tešić, Živoslav

(Vieweg, Wiesbaden, 2001)

TY  - JOUR
AU  - Aleksić, Mirjana
AU  - Agbaba, Danica
AU  - Milojković-Opsenica, Dušanka
AU  - Tešić, Živoslav
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/285
AB  - Chromatographic behaviour of six anti hypertensive drugs from the class of ACE inhibitors was studied under conditions of salting-out thin-layer chromatography on silica-gel, cellulose and polyacrylonitrile (PANS) as sorbents. For this purpose, different concentrations of aqueous ammonium sulphate solutions were used as solvents. In all cases studied, it was established that hR(F) values decrease with increasing salt concentrations in the chromatographic solvent Systems used. In addition, a linear relationship of the corresponding R-M values and ammonium sulphate content in the solvent was observed. To explain these results, a separation mechanism based on hydrophobic interaction between the sorbend and sorbent is proposed.
PB  - Vieweg, Wiesbaden
T2  - Chromatographia
T1  - Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents
VL  - 53
IS  - SPEC. ISS
DO  - 10.1007/BF02490373
ER  - 
@article{
author = "Aleksić, Mirjana and Agbaba, Danica and Milojković-Opsenica, Dušanka and Tešić, Živoslav",
year = "2001",
abstract = "Chromatographic behaviour of six anti hypertensive drugs from the class of ACE inhibitors was studied under conditions of salting-out thin-layer chromatography on silica-gel, cellulose and polyacrylonitrile (PANS) as sorbents. For this purpose, different concentrations of aqueous ammonium sulphate solutions were used as solvents. In all cases studied, it was established that hR(F) values decrease with increasing salt concentrations in the chromatographic solvent Systems used. In addition, a linear relationship of the corresponding R-M values and ammonium sulphate content in the solvent was observed. To explain these results, a separation mechanism based on hydrophobic interaction between the sorbend and sorbent is proposed.",
publisher = "Vieweg, Wiesbaden",
journal = "Chromatographia",
title = "Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents",
volume = "53",
number = "SPEC. ISS",
doi = "10.1007/BF02490373"
}
Aleksić, M., Agbaba, D., Milojković-Opsenica, D.,& Tešić, Ž.. (2001). Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents. in Chromatographia
Vieweg, Wiesbaden., 53(SPEC. ISS).
https://doi.org/10.1007/BF02490373
Aleksić M, Agbaba D, Milojković-Opsenica D, Tešić Ž. Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents. in Chromatographia. 2001;53(SPEC. ISS).
doi:10.1007/BF02490373 .
Aleksić, Mirjana, Agbaba, Danica, Milojković-Opsenica, Dušanka, Tešić, Živoslav, "Salting-out thin-layer chromatography of some angiotensin converting enzyme inhibitors on different sorbents" in Chromatographia, 53, no. SPEC. ISS (2001),
https://doi.org/10.1007/BF02490373 . .
19
18
21

Effect of increasing the bidentate chelate ring size in Co(III) complexes on their behavior in salting-out TLC on different adsorbents

Vucković, Gordana; Tanasković, Slađana; Janjić, TJ; Milojković-Opsenica, Dušanka; Celap, MB

(Springer Hungarica Kiado Kft, Budapest, 1999)

TY  - JOUR
AU  - Vucković, Gordana
AU  - Tanasković, Slađana
AU  - Janjić, TJ
AU  - Milojković-Opsenica, Dušanka
AU  - Celap, MB
PY  - 1999
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/223
AB  - The effect of enlargement of the chelate ring size in Co(III) complexes containing bidentate aminocarboxylato and/or diamine ligands on their R-F values in salting-out chromatography has been investigated on thin layers of silica gel, cellulose, polyacrylonitrile, and CN-modified silica gel. Salting-out was achieved with aqueous solutions of ammonium sulfate, Enlargement of the chelate ring caused a decrease in the R-F values of the complexes. By use of linear regression analysis and the theory of error propagation it was established that the logarithms of the separation factors of the pairs of compounds investigated were either unaffected or changed only slightly with changing concentration of salt in the mobile phase; this could not be established for certain on the basis of R-F values alone. Complete correlation was established between the chromatographic behavior of the complexes and the previously investigated effect of successive enlargement of the rings in cobalt(III) complexes containing hexadentate ligands of the EDTA type. The corresponding separation mechanism of the pairs of compounds investigated was also considered. It was finally established that the regularities mentioned were independent of the adsorbent used.
PB  - Springer Hungarica Kiado Kft, Budapest
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Effect of increasing the bidentate chelate ring size in Co(III) complexes on their behavior in salting-out TLC on different adsorbents
VL  - 12
IS  - 6
SP  - 461
EP  - 465
UR  - https://hdl.handle.net/21.15107/rcub_farfar_223
ER  - 
@article{
author = "Vucković, Gordana and Tanasković, Slađana and Janjić, TJ and Milojković-Opsenica, Dušanka and Celap, MB",
year = "1999",
abstract = "The effect of enlargement of the chelate ring size in Co(III) complexes containing bidentate aminocarboxylato and/or diamine ligands on their R-F values in salting-out chromatography has been investigated on thin layers of silica gel, cellulose, polyacrylonitrile, and CN-modified silica gel. Salting-out was achieved with aqueous solutions of ammonium sulfate, Enlargement of the chelate ring caused a decrease in the R-F values of the complexes. By use of linear regression analysis and the theory of error propagation it was established that the logarithms of the separation factors of the pairs of compounds investigated were either unaffected or changed only slightly with changing concentration of salt in the mobile phase; this could not be established for certain on the basis of R-F values alone. Complete correlation was established between the chromatographic behavior of the complexes and the previously investigated effect of successive enlargement of the rings in cobalt(III) complexes containing hexadentate ligands of the EDTA type. The corresponding separation mechanism of the pairs of compounds investigated was also considered. It was finally established that the regularities mentioned were independent of the adsorbent used.",
publisher = "Springer Hungarica Kiado Kft, Budapest",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Effect of increasing the bidentate chelate ring size in Co(III) complexes on their behavior in salting-out TLC on different adsorbents",
volume = "12",
number = "6",
pages = "461-465",
url = "https://hdl.handle.net/21.15107/rcub_farfar_223"
}
Vucković, G., Tanasković, S., Janjić, T., Milojković-Opsenica, D.,& Celap, M.. (1999). Effect of increasing the bidentate chelate ring size in Co(III) complexes on their behavior in salting-out TLC on different adsorbents. in Journal of Planar Chromatography - Modern TLC
Springer Hungarica Kiado Kft, Budapest., 12(6), 461-465.
https://hdl.handle.net/21.15107/rcub_farfar_223
Vucković G, Tanasković S, Janjić T, Milojković-Opsenica D, Celap M. Effect of increasing the bidentate chelate ring size in Co(III) complexes on their behavior in salting-out TLC on different adsorbents. in Journal of Planar Chromatography - Modern TLC. 1999;12(6):461-465.
https://hdl.handle.net/21.15107/rcub_farfar_223 .
Vucković, Gordana, Tanasković, Slađana, Janjić, TJ, Milojković-Opsenica, Dušanka, Celap, MB, "Effect of increasing the bidentate chelate ring size in Co(III) complexes on their behavior in salting-out TLC on different adsorbents" in Journal of Planar Chromatography - Modern TLC, 12, no. 6 (1999):461-465,
https://hdl.handle.net/21.15107/rcub_farfar_223 .
6
7