TY  - JOUR
AU  - Dabetić, Nevena
AU  - Todorović, Vanja
AU  - Panić, Manuela
AU  - Radojčić Redovniković, Ivana
AU  - Šobajić, Slađana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3638
AB  - In the past few years, research efforts have focused on plant exploitation for deriving some valuable compounds. Extraction has been usually performed using petrochemical and volatile organic solvents, but nowadays, increased recognition of environmental pollution has prompted the utilization of green solvents as alternatives. Therefore, the aim of the present study was to exploit deep eutectic solvents (DES) (choline chloride: citric acid and choline chloride: glucose) as solvents for extracting valuable phenolic antioxidants from grapes. Investigation was conducted on ten grape varieties, observing seeds and skin as different matrix. Total polyphenol content (TPC) was determined by Folin-Ciocalteu spectrophotometric microassay. Antioxidant activity was investigated using four different tests and results were combined in a unique Antioxidant Composite Index (ACI) to reveal comprehensive information about this biological activity. Polyphenol compounds were identified and quantified with the aim of HPLC-diode array detector (DAD). Overall results support that DES (particularly choline chloride: citric acid) were comparable to conventional solvent, and in most cases even outperformed acidified aqueous ethanol (concerning extraction efficiency and antioxidant activity). Regardless of varietal distinctions, grape seeds have higher antioxidant capacity compared to grape skin, and such findings are according to their phenol compound concentrations.
PB  - MDPI AG
T2  - Applied Sciences (Switzerland)
T1  - Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin
VL  - 10
IS  - 14
DO  - 10.3390/app10144830
ER  - 

@article{
author = "Dabetić, Nevena and Todorović, Vanja and Panić, Manuela and Radojčić Redovniković, Ivana and Šobajić, Slađana",
year = "2020",
abstract = "In the past few years, research efforts have focused on plant exploitation for deriving some valuable compounds. Extraction has been usually performed using petrochemical and volatile organic solvents, but nowadays, increased recognition of environmental pollution has prompted the utilization of green solvents as alternatives. Therefore, the aim of the present study was to exploit deep eutectic solvents (DES) (choline chloride: citric acid and choline chloride: glucose) as solvents for extracting valuable phenolic antioxidants from grapes. Investigation was conducted on ten grape varieties, observing seeds and skin as different matrix. Total polyphenol content (TPC) was determined by Folin-Ciocalteu spectrophotometric microassay. Antioxidant activity was investigated using four different tests and results were combined in a unique Antioxidant Composite Index (ACI) to reveal comprehensive information about this biological activity. Polyphenol compounds were identified and quantified with the aim of HPLC-diode array detector (DAD). Overall results support that DES (particularly choline chloride: citric acid) were comparable to conventional solvent, and in most cases even outperformed acidified aqueous ethanol (concerning extraction efficiency and antioxidant activity). Regardless of varietal distinctions, grape seeds have higher antioxidant capacity compared to grape skin, and such findings are according to their phenol compound concentrations.",
publisher = "MDPI AG",
journal = "Applied Sciences (Switzerland)",
title = "Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin",
volume = "10",
number = "14",
doi = "10.3390/app10144830"
}

Dabetić, N., Todorović, V., Panić, M., Radojčić Redovniković, I.,& Šobajić, S.. (2020). Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin. in Applied Sciences (Switzerland)
MDPI AG., 10(14).
https://doi.org/10.3390/app10144830

Dabetić N, Todorović V, Panić M, Radojčić Redovniković I, Šobajić S. Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin. in Applied Sciences (Switzerland). 2020;10(14).
doi:10.3390/app10144830 .

Dabetić, Nevena, Todorović, Vanja, Panić, Manuela, Radojčić Redovniković, Ivana, Šobajić, Slađana, "Impact of deep eutectic solvents on extraction of polyphenols from grape seeds and skin" in Applied Sciences (Switzerland), 10, no. 14 (2020),
https://doi.org/10.3390/app10144830 . .