TY  - JOUR
AU  - Micić, Sava
AU  - Lalić, Nataša
AU  - Đorđević, Dejan
AU  - Bojanić, Nebojša
AU  - Bogavac-Stanojević, Nataša
AU  - Busetto, Gian Maria
AU  - Virmani, Ashraf
AU  - Agarwal, Ashok
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3347
AB  - Carnitine is essential for energy metabolism and spermatozoa maturation. Combining L-carnitine and L-acetylcarnitine with micronutrients has been investigated as a treatment for infertility in men. We evaluated the effects of a therapeutic formulation, Proxeed Plus, on sperm parameters in oligoasthenozoospermic men. This prospective, randomised, double-blind, placebo-controlled clinical trial involved 175 males (19-44 years) with idiopathic oligoasthenozoospermia who failed to impregnate their partners (12 months). Males received Proxeed Plus or placebo for 3 and 6 months. Sperm volume, progressive motility and vitality significantly (p  lt  0.001) improved after 6 months compared to baseline. Sperm DNA fragmentation index significantly decreased compared to baseline (p  lt  0.001) and the 3-month therapy (p = 0.014) in treated men. Increased seminal carnitine and alpha-glucosidase concentration also positively correlated with improved progressive motility. Decreased DNA fragmentation index was the good predictor of progressive sperm motility >10%, and simultaneous measurement of changes in sperm vitality and DNA fragmentation index gave the highest probability of sperm motility 10% (AUC = 0.924; 95% CI = 0.852-0.996; p  lt  0.001). Logistic regression analyses revealed DNA fragmentation index decrease as the only independent predictor of sperm motility 10% (OR = 1.106; p = 0.034). We have demonstrated the beneficial effects of carnitine derivatives on progressive motility, vitality and sperm DNA fragmentation. Combining metabolic and micronutritive factors is beneficial for male infertility.
PB  - Wiley, Hoboken
T2  - Andrologia
T1  - Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia
VL  - 51
IS  - 6
DO  - 10.1111/and.13267
ER  - 

@article{
author = "Micić, Sava and Lalić, Nataša and Đorđević, Dejan and Bojanić, Nebojša and Bogavac-Stanojević, Nataša and Busetto, Gian Maria and Virmani, Ashraf and Agarwal, Ashok",
year = "2019",
abstract = "Carnitine is essential for energy metabolism and spermatozoa maturation. Combining L-carnitine and L-acetylcarnitine with micronutrients has been investigated as a treatment for infertility in men. We evaluated the effects of a therapeutic formulation, Proxeed Plus, on sperm parameters in oligoasthenozoospermic men. This prospective, randomised, double-blind, placebo-controlled clinical trial involved 175 males (19-44 years) with idiopathic oligoasthenozoospermia who failed to impregnate their partners (12 months). Males received Proxeed Plus or placebo for 3 and 6 months. Sperm volume, progressive motility and vitality significantly (p  lt  0.001) improved after 6 months compared to baseline. Sperm DNA fragmentation index significantly decreased compared to baseline (p  lt  0.001) and the 3-month therapy (p = 0.014) in treated men. Increased seminal carnitine and alpha-glucosidase concentration also positively correlated with improved progressive motility. Decreased DNA fragmentation index was the good predictor of progressive sperm motility >10%, and simultaneous measurement of changes in sperm vitality and DNA fragmentation index gave the highest probability of sperm motility 10% (AUC = 0.924; 95% CI = 0.852-0.996; p  lt  0.001). Logistic regression analyses revealed DNA fragmentation index decrease as the only independent predictor of sperm motility 10% (OR = 1.106; p = 0.034). We have demonstrated the beneficial effects of carnitine derivatives on progressive motility, vitality and sperm DNA fragmentation. Combining metabolic and micronutritive factors is beneficial for male infertility.",
publisher = "Wiley, Hoboken",
journal = "Andrologia",
title = "Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia",
volume = "51",
number = "6",
doi = "10.1111/and.13267"
}

Micić, S., Lalić, N., Đorđević, D., Bojanić, N., Bogavac-Stanojević, N., Busetto, G. M., Virmani, A.,& Agarwal, A.. (2019). Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia. in Andrologia
Wiley, Hoboken., 51(6).
https://doi.org/10.1111/and.13267

Micić S, Lalić N, Đorđević D, Bojanić N, Bogavac-Stanojević N, Busetto GM, Virmani A, Agarwal A. Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia. in Andrologia. 2019;51(6).
doi:10.1111/and.13267 .

Micić, Sava, Lalić, Nataša, Đorđević, Dejan, Bojanić, Nebojša, Bogavac-Stanojević, Nataša, Busetto, Gian Maria, Virmani, Ashraf, Agarwal, Ashok, "Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia" in Andrologia, 51, no. 6 (2019),
https://doi.org/10.1111/and.13267 . .

TY  - CONF
AU  - Micić, Sava
AU  - Lalić, N.
AU  - Đorđević, D.
AU  - Bogavac-Stanojević, Nataša
AU  - Virmani, A.
AU  - Agarwal, Ashok
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2841
PB  - Oxford Univ Press, Oxford
C3  - Human Reproduction
T1  - Seminal carnitine and DNA fragmentation index (DFI) impact progressive sperm motility in oligoasthenospermic men treated with metabolic and essential nutrients, with moderate accuracy
VL  - 32
IS  - Supplement 1
SP  - i132
EP  - i132
DO  - 10.1093/humrep/32.Supplement_1.1
ER  - 

@conference{
author = "Micić, Sava and Lalić, N. and Đorđević, D. and Bogavac-Stanojević, Nataša and Virmani, A. and Agarwal, Ashok",
year = "2017",
publisher = "Oxford Univ Press, Oxford",
journal = "Human Reproduction",
title = "Seminal carnitine and DNA fragmentation index (DFI) impact progressive sperm motility in oligoasthenospermic men treated with metabolic and essential nutrients, with moderate accuracy",
volume = "32",
number = "Supplement 1",
pages = "i132-i132",
doi = "10.1093/humrep/32.Supplement_1.1"
}

Micić, S., Lalić, N., Đorđević, D., Bogavac-Stanojević, N., Virmani, A.,& Agarwal, A.. (2017). Seminal carnitine and DNA fragmentation index (DFI) impact progressive sperm motility in oligoasthenospermic men treated with metabolic and essential nutrients, with moderate accuracy. in Human Reproduction
Oxford Univ Press, Oxford., 32(Supplement 1), i132-i132.
https://doi.org/10.1093/humrep/32.Supplement_1.1

Micić S, Lalić N, Đorđević D, Bogavac-Stanojević N, Virmani A, Agarwal A. Seminal carnitine and DNA fragmentation index (DFI) impact progressive sperm motility in oligoasthenospermic men treated with metabolic and essential nutrients, with moderate accuracy. in Human Reproduction. 2017;32(Supplement 1):i132-i132.
doi:10.1093/humrep/32.Supplement_1.1 .

Micić, Sava, Lalić, N., Đorđević, D., Bogavac-Stanojević, Nataša, Virmani, A., Agarwal, Ashok, "Seminal carnitine and DNA fragmentation index (DFI) impact progressive sperm motility in oligoasthenospermic men treated with metabolic and essential nutrients, with moderate accuracy" in Human Reproduction, 32, no. Supplement 1 (2017):i132-i132,
https://doi.org/10.1093/humrep/32.Supplement_1.1 . .